<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J370</accession>
    <name>A0AA38J370_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1134617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000079">
        <property type="protein sequence ID" value="KAJ3716264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J370"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="382"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="837"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="551"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="714"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3716264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1189" mass="127778" checksum="652BC652B4B0BA63" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3N3</accession>
    <name>A0AA38J3N3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1099772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3N3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="79"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3717310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="367" mass="41181" checksum="34319CF30D8608FA" modified="2024-01-24" version="1">MSSTIVQTQSESAPAALKLQASANGKPEKEEYRYSHLLPVFSQDHYPPLTPFEHSDPGHRALNHPNPRSFLDSAASIIELTPNLGTEVHGVNLRALDSDARDQLALEVARRGLVVFRDQQEFIDAGPDFYREWGSHFGRLHIHPTSGHPQGYPEVHLVYRDANSSFNFEIEDSITSTVWHSDVSYELQPPGLTTFFLLSQPSTGGDTLFTSQVSSLKKLSPQFVAFLKTLKAVHSGIEQANFSRSGKRGGIVRREPVEHVHPLVRKHPVTGEEALYVNRQFTRRILGLKREESETLLKFLYDHIDKGGDVQARVHWTPNTVVLWDNRVTAHSAIVDYGESKERRHGARITPQAERPIPALEGLDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4K0</accession>
    <name>A0AA38J4K0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1205484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4K0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="348" mass="36957" checksum="56A1038F25DE9BF0" modified="2024-01-24" version="1">MSQKALVLEKPKSPFVLSSIPIPKPGAGEVQVKVLACGLNPVDTAVQARDIIPNVKYPTILGLDVAGDVEEVGEGVEEYVKGDRVFFSADYSMAHGGLQQYTLKSVSDPDIGKIPPHISYNEAATIPLTFATAVIPLLSVNPIGAGLNPTFDSKVNFDGEAALVIGGGTSVGQFAIQIYKYLGFSTIITYASLKHSDYLKSLGATHVIDRTQVSISTLFDSVKTITSLPIKNVYVASIMVEGAMEAGYACLAHGGQMATASPAPPKPDDAEATGRKIYGVFASVNIEPNKEFGKELWKNLPRLVKEGIIKPNRIEMLTGLTAVPDALPRFMNGGVSGVKLIVNPQDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J598</accession>
    <name>A0AA38J598_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162307</name>
        <name evidence="3" type="ORF">DFJ43DRAFT_1207180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000147">
        <property type="protein sequence ID" value="KAJ3710056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J598"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="283" mass="29903" checksum="AAA6293BAA2F058A" modified="2024-01-24" version="1">MFTFSQSSSLSTWKVEVVASKALGPRVNSSSSTKIEKSPAPKDTRPGFAPSSPTKLKKSCTMFSYVPVMPRLINSDTSVLGRLDHALAALAKPPPAMEPSHPNTSIGFNRDDPDSSIVHGGGRINSVPKKGREKSIFTIGIGRPSTSKTSASGYMAQASSSKPTTSAFASSKLVAQSQLSQFLPPRTGPGLQKNYHAGAANRFPVGGSLGSRGKKAIQKTTLPSVVASPVKGSVGVSRDDDIEMVDVDMTMLDISMSGNRSDMNISESEVSDTSGSRNNRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7D2</accession>
    <name>A0AA38J7D2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L14-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1104969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7D2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3713729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="136" mass="15321" checksum="1B79ADE448D83F8F" modified="2024-01-24" version="1">MSDSTFKRFVEVGRVVLLKSGPYAGKIAVIAEIIDHKRAVIDGPTTSVPRQSYPYKHLTLTPLALTKLPRGSRSGAIKKQLEKEDTLTKWNNSEWAKKRAAVEKRRGLNDFARFSVMLEKKKRRDGVRKAVKASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7R5</accession>
    <name>A0AA38J7R5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1107915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000121">
        <property type="protein sequence ID" value="KAJ3711270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7R5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54539" checksum="1C888AAEE07441E7" modified="2024-01-24" version="1">MLNADLISLICGELESGTSRALHHGYRTRDDVDCRKGLLSLALTSKAFSEPALNVLWRKISSVEPLLSVLPDIMILDGKKTILEQITPSSWDRLHYYARKVREFEEQDSSNVHESVYALLGQSKPIFPNLVELRPGLQISTNSLIFFLTSSISNVSIPWPIRMPSNTHDLGPSLALLASKNPGLKYLSISSVAVSGISFSLRCFRNLRTLVLGRLPQYEPDYVQILASLDDLTSLTLTLPRDDIFQYGSIQNGFPSLERLSIAGFTLNLRGFLKVVSSSILQDLSLRWEEPPALFADAFSVTNTLGRFSSLQELIIENATSVLVDDFDRRSDYWALFMPLLQLNQLRSLTYSSPLVLTDELTAKIALSWPHIVNLYFTAAQWLEVPPVSSLAHFVRGCQNLRALRCPIRVDVSTGTAPPEPTLFMHPLRSFHCSKHDDVLDPACLALALHQLFPGLRSVTGDGDGWDEVEAILKTYHFLLIQDRRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7W1</accession>
    <name>A0AA38J7W1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1002189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7W1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="506" mass="57591" checksum="D38F42BB4FE45FD4" modified="2024-01-24" version="1">MFPIPSAATISTLVKAQKPWPPSPEENRLQEAESSEARVRLPRITGGLPRPNEDLFAFIKRRDERRLRVISSETTLEHQSRLQREENAGRDRPPGRKGARVYYWDLVEGIRVRTAVGRSNYEDIWERYGSHQRRYDSVADEWDICTDLDPHDGPDYDDLDSDDDYDAYFMSANSEMNEEGDHNVGAASSDAFLVRLHRSNDLPPASIQFLEPIVDTAYHRFGFLKQPMQDGRELIISPKIWMKTLGLLGHGRPPLPQGPDDQTKLQLCQFITDLLASSDLQHAPRLCDLAATDIHRRPLIPFEVDAVSSYNGLWFIIQAREARDNEAFSIGLRSAATVMEIARRRWGPRTEDILKCLINEGMPFNTLKASHSPRERKVMPRRRHAILGFRPAGFSPTLQDYHAYEVLRDDFLRSARGRAALLAGGIVARLARDAVNEQDVYDGPTENALQEGEHVLCVWEEGKHFALWDDNLTEEEIDLICGTYEVATGMSHPFTYHDTPNSKCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J829</accession>
    <name>A0AA38J829_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J829"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="23369" checksum="88D7356B59749B5C" modified="2024-01-24" version="1">MSKSPSTVSRSSPYKRTITYSKRDKARATPTRLPQTHSLPNTPTRQTPHALSSGNRVFKDVIDVDSDSDSDIRSPLVTTTRQVSQGSASSSRNVSKDVIDLSNDDSDTISLPAAIGKRLAAALDELEVTKKKVEKYEALTIEENTCETKAGHQLHSTTCGYCCAAISRPPILSLEWQNRVDDMALEQGIPIPERTEFQWPPPPGTPKRLRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J875</accession>
    <name>A0AA38J875_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_875440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J875"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="190" mass="21702" checksum="315012C0D9D5E8BB" modified="2024-01-24" version="1">MELAGTKVPVPRVLRYGQSGNCSYILMERIPHHNLAVAMEHWGINSMPWQWTQAVDYVVRELAKLGLSHNDLVPRNVLVNDHGIISAIVDWDPCTQHSRGGEYARMITELDPSRRDFGERDWYYIFLRYASDRTGEEIMIGCSEWNPKLGLQWPLVKSKASHLVSPPITDPRNQSFSRQKVCPVGTKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8F7</accession>
    <name>A0AA38J8F7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CxC6 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1155581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8F7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040898">
        <property type="entry name" value="CxC6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18721">
        <property type="entry name" value="CxC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="2">
        <location>
            <begin position="44"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CxC6 like cysteine cluster associated with KDZ" evidence="3">
        <location>
            <begin position="259"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="64285" checksum="A0B1365A3109E37F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8T6</accession>
    <name>A0AA38J8T6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1102508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8T6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3715229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="237" mass="26016" checksum="22E7AD357716F70D" modified="2024-01-24" version="1">MLSPNHHEVSSPSHFQQLLSADLDRVSVLNFWADWAEPCKQMNAVTLELAKKYPSILFLQIEAEAQSDISESFDIESVPSIILLQGHTLLQRISGADAPAITAAVAKFASVSSTNPQSKTDLPPATASNTAVSNPSEDLESRMTKLMNQSKVVLFMKGSPDAPRCGFSRRICGLLQDQKVKFTHFDILSDESLRQGLKKRNDWPTFPQLIINGEFVGGLDIVQEMVENGEFAEALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9M3</accession>
    <name>A0AA38J9M3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1141560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9M3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="847" mass="94995" checksum="B0167D126BEAB541" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9Z8</accession>
    <name>A0AA38J9Z8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1000003</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9Z8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041319724" description="Endo-1,4-beta-xylanase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="16">
        <location>
            <begin position="32"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3731064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="283" mass="29262" checksum="3037E10F2517538B" modified="2024-01-24" version="1">MAYKSLLSLALLAVTAAALDVFDNSTEIIGKRSIPNGEGTNNGYFYSVYSDSSVTGTYTNGAGGEYTLTWGGSGDVVVGKGWNPGGPMSVEYSGTYAPNGNSYLSVYGWMTSPLVEYYITESFGTYNPSTGGTHLGTCTSDGGVYDIYTQTRTNAPSISGTATFQQYWSIRQTHRVGGTVTTGNHYACWESVGLPLGTFNYMILATEGYSSSGTSTITVGQGTGTGSSAPTGPSSTTSTPGSVPTGGSVAEWGQCGGIGYSGPTACASPFTCTVINSYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA19</accession>
    <name>A0AA38JA19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_286381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA19"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="719"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3732652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="772" mass="86479" checksum="D1FECE1CE0817F71" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA88</accession>
    <name>A0AA38JA88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_789644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA88"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="3">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3717652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="261" mass="27112" checksum="F0A6DC7E7BA286F7" modified="2024-01-24" version="1">MAVSKKSSTIKTKTPSGKSHNAAHPTWIDMIKECIIAYPEDARTGVSRPTIKKFVENKYKIDVNASTASQLNRAITSGSEKGVFVLPKGPSGKVKLAPKVRSDATKENATPAVKKPVSKSKAPSTRLSASKKAPTTKASAPEKVRPSKASAVLKPSPTKAPTVKKYSSSKKSAQSRATTLNKKVAPSKNSASTARKPSNSKKGSTTKGTATAKKSIANKPKVANARSSASKAKASVPKAKPIAKASARPKSATKKAAAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB42</accession>
    <name>A0AA38JB42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_811888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB42"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3716322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="245" mass="25833" checksum="C3C0D03ED7C91B9E" modified="2024-01-24" version="1">MLQHHLNIGGTVSIVRRCPRHSPSGFVNHLLGFPEKSSTLGYTSFYPGQVPLHPLEFTAPVGKFKPYPATHATIQPSSSLCNLFSSSIGSSLYGLLSCLGMYERHSWDNSGNIQVLRLQKCHQHSVSRGAMHFPVLALALALALAGVSFVSAVPAADSLLPCAICPPTATSSDELLPLVLISAAEGTIGLTLQCTYVGVPNLSELTCTYFNLDGALLDSSDDITCGETATVLTQPGIGPCIALPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBK3</accession>
    <name>A0AA38JBK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1067784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBK3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="115" mass="12629" checksum="656C36B6E13C6884" modified="2024-01-24" version="1">MPAYNGHMLAQSLDSTSSSTAVSSNSKPKTPIIAGSVCGGVLGLAWIIGFAIYFRKRYKRKLRNQGKLPPLKVKKSKDEPREKIVIPPDPAVLIGHQPGDDVDRNNEHEKSHNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBW1</accession>
    <name>A0AA38JBW1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome biogenesis protein Noc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1004647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBW1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="4">
        <location>
            <begin position="421"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3721376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="687" mass="76853" checksum="907374D62EB8C2BA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBW2</accession>
    <name>A0AA38JBW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_780830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBW2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="249" mass="27872" checksum="631696422D73637A" modified="2024-01-24" version="1">MLLQQRTLSFLGYLLIANVLLLTVHSIPLATTTNHLESRMPRVRNKLTKMTLRVGFKPKGQDHYRNAGRLRNGRKKNIEVSPDEDAILCFGGTICFQFDRDESGLPCVKPIEPRTNGNGMNPRLVDLASTGQLVARFQESVGREDLISMFGNPKTLLEQTQAALREKGANSGADALSVEDDDDYISVVLIWLQLQERTGKEVGPVLDKLVDNYGVWLNIYQSRKVVKGRVSLETTEVMNLLKGIYSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC57</accession>
    <name>A0AA38JC57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1005538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC57"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3719089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="156" mass="16545" checksum="357F795B721CEFA6" modified="2024-01-24" version="1">MAPREYSLRLQKGITGGFAPPTPSFIATITRPIDSDSLNITSASRPDGTPELQSFAPKTLTLGHAAQLTGASTSTEALIDELHGILKQLPTEQPPGSEDIYGLDTSIFWGSDDLQWVNGGMNGVNGQPGSVQATPEQKAQFKRAVEIVEVLVGEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCD5</accession>
    <name>A0AA38JCD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SNTX MACPF/CDC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_547110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052090">
        <property type="entry name" value="Cytolytic_pore-forming_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056072">
        <property type="entry name" value="SNTX_MACPF/CDC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594">
        <property type="entry name" value="AIG1-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594:SF14">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24674">
        <property type="entry name" value="MACPF_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SNTX MACPF/CDC-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3727370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="687" mass="75334" checksum="3D0698CED8CC16E5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCT4</accession>
    <name>A0AA38JCT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_996665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCT4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="213"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="480" mass="53805" checksum="6D9439A483C5685F" modified="2024-01-24" version="1">MSSEVERLLDTITRAVKSLNLACSSSGTSVPSINEPFQPSSENFRGSFEALQAARIISAAALQLEAVVAPPQVVLYHVVGGFFKSMALRVCLESNVTEILREAGPEGMHVRDIARYNGQDSQKLARFLRYLCSNHVYREVSPDVFANNRISSLLDTRKTIDELRSRPLDKYKNTDGTAALVGHHLDECFKGAAYAWETLNDPDMIHAKEHLGTPLNKAFNSETPYFNFIQNDDHRRLRFDVSMQGMERVQPPDTTLNAFEWGKLPEGSKIVDVGGGVGSVLFPLAENFPELKLVIQDLPGVVDNARKVWTERMPSALQTGQVTPEAHNFFNQQPQKETSVFLLKHVLHNWSDTSCVEILKRLRDASSDFTRLVVMDSAMPYVCRARNQRTSFMDIPMTATEEAPDPLLANYGALNEISYVLDMVMFVILNTQERTYEQLDKLLNESGWTISSVKRRPGDAAFVQIEAEPNKTFNGGQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCV0</accession>
    <name>A0AA38JCV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_293453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCV0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ras-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="121" mass="13709" checksum="63AAE075F57A2699" modified="2024-01-24" version="1">MSRALNTTRIIVSSNAEQYRVVEITGAPNGSYIRERILSKMCVPDNSFSRYSIYQSEIGAYALGDALSDSDLFKLCLQYGDPSGSLRLFVSTAPNRPPTRNEPEYPLENGYYSNSRYYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCW5</accession>
    <name>A0AA38JCW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="134" mass="14785" checksum="D3143C5CF397CF9F" modified="2024-01-24" version="1">MSRVWTPAKLSATPSTTAGASRKTVKGPSLSSEKHSTHTWPRPPPPKRNIAVTQKWLDDITVRQMEREKFKNPMLTTTEISKKRDDPRPKPPVVPTPTGSGTQTPKTEAEQEAKKQEGGKLKEEASGPSEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDE9</accession>
    <name>A0AA38JDE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1124345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDE9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="270" mass="29312" checksum="5EF6835C3CD33078" modified="2024-01-24" version="1">MSSSSSTSRSPSSEPLKDNSVSESSSKDISSHSSLKDTEEGSTTQESTEERSEKDAESSELTTSGAAIPASEASSTPWQAIYSPQYSAYYFFNSETNETTWENPLAKASDSTTPNPGFENPTEPSNSAHAPAEGASNGTTLPSYDALQAAAIAQGIDPSLAHLDPSLAGPVASSSLGAYGAAAKFNARTGQFTRVDARDPSHLSEYERAKRMSEFYFDVNAWEKQRVQEQETEAAEGSEKKRKRPSKKDLEKFKEQKRQKKIAKTAWLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDG9</accession>
    <name>A0AA38JDG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1197156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDG9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="288" mass="32143" checksum="B027E4FFC8F86BB8" modified="2024-01-24" version="1">MRVDVILFHKLFIAYIVLISCLGVIASPVIGRARSDLSLLPAGFIVDAHSNWILAFLNNKSKKILMFSKDATEKVEFEWRDSSDNMAKGLIMFKDAQSQNIELILTQPVDEVSLLSASTKMTKDAEWIESAMAQLIIRHNSMQHQVTEAKMIDVTNISQLVKKQAQAMSKAGGRGPPFLLLPAGFMQSNWMLAFRGQRLNNILIFSKDANNKVNFKWLDSSDNTAEGLIMFKDAQSQNIELMLLSPSEEVNFLSASTGTTQGAEKAAKNINTAYIELVKKQVEEAREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDR1</accession>
    <name>A0AA38JDR1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1003949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDR1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 32 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3722728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="85152" checksum="DDC2C77BE60ACCEB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEC1</accession>
    <name>A0AA38JEC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1002033</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEC1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF46">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3726480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="167" mass="18201" checksum="A1E42E9487599AE6" modified="2024-01-24" version="1" fragment="single">TGNRHPEPARAVTDRLNVPLVPCTVKKFSNGEINVEISESMQDEDVFIIQSGCKDAKDNLMELLILISASKTASARRIIAVIPSFPCARIDESQAPITAKLAANMLVVAGCDHVITMDLHASQIRGFFDIPVDNLFSEPLLLLYIKRSTEGWKNGIIVSPDAGGAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEE6</accession>
    <name>A0AA38JEE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinon protein alcohol dehydrogenase-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3723626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="382" mass="41820" checksum="308AD3F8FCFD9D11" modified="2024-01-24" version="1">MLFRKSKFFKKTATLRGSQDGINALAFSEEGKFLAAAGRGGAIIWDLATLSEVTTPSALIQSKTWDAARSFNTVEWMYFREQESTHILLLGSDAGEVILLGWVPERKAFRIIQRLPPEEAGDGVISMHVYEREPSQARAYFVVATYGGRVSVRRLTLTGCHILFSTTVDYELVAVRFYPRTRDVYLFAAAGGLIACLDKETGQTIFSGRLGPETMGSICVDSTGDRFVVGTARNFEMFNFKDVGYLQTFVCRKPIVPFPKDAAFTDDGLALVGGTDYGVAAVFDVNSGAMVQTLNYPEGGLVQTVAVYTSSDTHTIAIAGSTLNRPAEVILFQKSRPSNPLPPTNSYYKIVGPQSWWLSCLILIPLALIGCHTLASIVFPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEW5</accession>
    <name>A0AA38JEW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_894153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000099">
        <property type="protein sequence ID" value="KAJ3713461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="229" mass="26098" checksum="B105528695CF9149" modified="2024-01-24" version="1">MPILPPASLPDKCTCCRGNADSGFKTCTACRKKRNAYQKQRNRKKRAKDILSSYDLDIEKKREKTLLNDTMIFGTEFQSATEMYRQLKSLVRMNARLNYKACHSIVADPECGHKKRALLVARDVRKVAHVPFNHKGAPAHPSQSLSFHTLQFRCTCMTSDSSQRVVGKQANYLGNGDAENGTCQGEVEVTVLDDLRHPSGIAARFLYHHLFFRPEYNSPRICRTQWRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFF4</accession>
    <name>A0AA38JFF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fruit-body specific protein a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFF4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041240120" description="Fruit-body specific protein a" evidence="1">
        <location>
            <begin position="18"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="23322" checksum="FBA650CF37DC5436" modified="2024-01-24" version="1">MLSSVVVIISLSLTTLAAYLPPINILDDLDSTEYIVASLAASNHHGAPYPPELAGSTPGWYFGDDPGSAEGLPWMKDTDLCAVLAQTTGSLRCPPAVQKPTKVLPKRSAAVAAPTQSSTTSSSTPSYYTVFSGRSGAIQGSGYLTYGLVDTVANCQTMCNKVSGCVFVNSYHDVNGKNGSPLLTCSLYSIVHTASQATNYGGQLQPDGSYDYITDSAGYALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG16</accession>
    <name>A0AA38JG16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1155937</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG16"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3731112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="16502" checksum="CD26BBEBDE1C314F" modified="2024-01-24" version="1">MSVCPPYAPFFGFAGVASAMVLSTIGAAFGTAKAGIGIAGLGTFKPELIMKSLIPVVMSGIIAVYGLVVSVLISGALTPEGYPLFAGFIHLGAGLACGLTGLTAGYAIGIVGDACVRAYVQESKVFVSMVLILIFAEVLGLYGLIVALIMNSKVAGGVGEVCYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG73</accession>
    <name>A0AA38JG73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_473174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG73"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="302" mass="34029" checksum="8CC7083A99C3F520" modified="2024-01-24" version="1">MFKSASRRLMSSQATLALGRAPKAPSQPPKLAEKTPYPLPTSSRGVERRRLDDMHHGIARYLKQLTFAPIENPSRILELGSGTGAWSVEAARTFPSAEVIAADMSPLPETLNTLPNLTFKQMNFLEPFPFRPETFDVVHMRFVLMHLPQPDNYIHRLASLLRPGGWLLLEDVNHTLLDANRPIGPGVQALYRGYREHMHNQGVDPGVGARLKNMLETSKKFSEVNEIVIPCYMNPNSTEDLALQELGQILKYSIDGVYVGIMDKVGPTGGITPEILRGWRKEVNDPERDLRIDMHLTWSRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGC5</accession>
    <name>A0AA38JGC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1094853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGC5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3721372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="400" mass="44950" checksum="9046B27AAF1584AF" modified="2024-01-24" version="1" fragment="single">QKGYLVSDDDDDDDDSQSSSSNLPSCRMKPMNFSTIATPHLGLIRYSTLFSSLAHRLGPKLLSRTGEQFYLQDRNTSTGRPLLDMMSDPDLPFYRSLTMFKQVRVFANAVNDLTVPYVTAAMEEEDPFVDWEEKGLKVEYQPRYRPLITSYTLSSSTAHQSKTRHSKPLIPLPPFLVKPFPFNILVYALLPFLVPLAFVLVFVRFTRATGRSRLRISQLEKRFADRQSLSLMQALSDLERQVERRIEDAVVDAIDDPVGDSTATNTNSPGTSTPSDRERMSPSPSPSPPSSTYKSSPNKESSKNAPLLTPLQRTICARLNTLPGLKKEIAFIDEFVDGDEEHISSLNPTSQTTKRSKKTTAKSIPIRNSHAPIVSRDVRNFEHHRIGEGVLRCWAEGLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH45</accession>
    <name>A0AA38JH45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1004061</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH45"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="122"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="15">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3722714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="261" mass="29454" checksum="1FF1C6CADD69D73C" modified="2024-01-24" version="1" fragment="single">VQNPSLSSTQEPDAEQTPLRTHVTGSARTEGFYKITHAEKAAYVTQYQSRTTNAEATAAQELLLEESKPQHITSSRSNRANARRRAQGLEEINQVQRAVALSKGEAASELTFKFNQLQTRKKHLRFARSPIHDWGLYAMERISRGEMVIEYVGEVIRAQVAEKREKAYERQGIGSSYLFRIDEDLVVDATKKGNLGRLINHSCDPNCTAKIITISGEKKIVIYAKQDIELGDEITYDYHFPFEQDKIPCLCGSAKCRGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHH7</accession>
    <name>A0AA38JHH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_996452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHH7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3732889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="541" mass="60077" checksum="431C53233E0AC8EF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHW1</accession>
    <name>A0AA38JHW1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_998963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHW1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="419" mass="46579" checksum="1559702592B01030" modified="2024-01-24" version="1">MGPRRPSNPAINLVGRQRNGSVSSLNSNASKLRTTPSAPHSPRFQSPAPKWRGYTMDAAKWTFSSSQLQSIVSRAIRQSAEASAIRLLRLETVDHDIPVELHKLEMQRTDVKTRYKMLSRRRTEMLATLTSYCDGTLHQDPSASLRVINELRDLTSTLDHLAEDLHSVDEQISQLSSLRDIHDASALAMAIRKLNASFLKQLAISDALRSQVVALEAERDDAWKQAESMAHEFDRLNEKADNADGSVINRSGRVTAMRKSSIRVSKAGLRSTRSSMSSTHRLSSASFSGGIKSAFSIEDIPPVPPIPRRPHRPVNISTDLPSTKSFIVSGPTPNTETRAMYEELCDMLGIPSTEFRPRRSRSVIERPRVSAKLEETFPNTVESRSSTSSGRPLSMPDRSGLTEVYQHMSADVCPLEYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIK0</accession>
    <name>A0AA38JIK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1157365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIK0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="278" mass="30843" checksum="BDFEACC965FBA74B" modified="2024-01-24" version="1">MASPGVNESEREAVKALVLQMEARRNKVEHTTMDSKSQSSEMDPAPSTPIPTRPVAPTKPPKPIIGKLPANYVPPQEHSIGILPKEDSRNFRYKAPIGSEVAVSRVIEAGFNSTVSVRHEDLLAIAPDYCRQMKESVTGKCIGIEGNFVNGGEGKIGQQYDYLIHWKDQPNSEDSWVPLSDLPNSTNETIERFHRRHPRTKRPPSSVLSSSRQLTFTPQSDDVEIDSADPSRPTPPIADRRSMLPAPINPNLRINYEPPTQTMTRSGRVAKPPTQLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIL4</accession>
    <name>A0AA38JIL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1002471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIL4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19445" checksum="B4F8C54BA6D04059" modified="2024-01-24" version="1">MAGRLWISVWFILTAPLMLWDAGFCLMRPRSMVGGDLHWIWAFYEFYGDVDHVYGVKAFEDGEGFANAAAVLNVIENVFGIVYLWTTHVWPSELATLAGYTGSAMTLAKTLLYVSQEYFCGFCATGHNTLSGMLCYWILPNVAWITMSGLIMYHLGKDIVRSSRLTSGRVKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIZ5</accession>
    <name>A0AA38JIZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIZ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="275" mass="30764" checksum="3B46328B1C4A8869" modified="2024-01-24" version="1">MALDATLGVFEIGILIAGVLFGVVTAQVYIHHKTFPEENRWIKFGLVDSMWLIELGHTMCVFHVVYFYTVTHYGDPSSLQVLPASIGAAVVLHGLTIMIVQGYFTYRIWRFTEKLYIPVFSCFLMFCQLLAVMTLASQLITIATKSLAKFMAKWEWLMFTVLVLRAIADITVSGSLVFHLLNGRRGALKSTVAVVDKLILWTIVSCPQDDVSLVGSSDATTESFLKHYACEHELPSYSAKYAFIRGGNRKVNIQQPSRNRPASSLTETGKYLSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ69</accession>
    <name>A0AA38JJ69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="168" mass="17894" checksum="3547F26ECB17731E" modified="2024-01-24" version="1">MSSSNDFSAADAARPTHHVHGSNDPLPGAKRGVNAVDYSAETIERTPSTWNERTEEQFAREQPGLRGATPDERHHAHHDNHGEGHHGSRTDTSEQRPMGAQPTHGGGVAVGADANTPESKPSVIDKVVGKTQKIVGKATHKSEMHEKGELRETGGKAASQAAVQTPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJT2</accession>
    <name>A0AA38JJT2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1094073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJT2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3722117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="191" mass="22335" checksum="428FBFF0E4688AE2" modified="2024-01-24" version="1">MSTDVVTQLTMDFPELAYLSRQDLEDLLNDTNYFQAVFHSLPRVKAMYDAQAELGNANESIAKNNLALQEKLYKLRSETQDAFNEAKSLEARWKELEKEQRDVYQRFTPQFLHMRLRHSITAQDDASERLATAFIQHQSLGPSETQSGTATPSGKEIDDFIKEFKEARKIYHKRVIWSDRWSKGQVEWRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK74</accession>
    <name>A0AA38JK74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_988792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK74"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="409" mass="44265" checksum="7967C00899C6F505" modified="2024-01-24" version="1">MSQAKISDAAKAKVAEEIKFDILAGVPELEGDNELKRSQIARTFISDTITVPTKEMYSYALLASLGDDVYHEPSTAQYAKQTYSALEAHIANITGKEAGLFMPSGTMSNQIGLRTHLMQPPYTILCDNRAHIYKYEVGGAGFHSGAAVTPVAPSNGHHLTLKDVEANIVYGPDVHFAPTEVIALENTLNGTIFPQDDIIAISQFARSKGIKMHLDGARIWHVAAETGISLKELLEPFDTASLCFSKGLGAPIGSCLVGSKEYITRARRIRKLFGGGMRQTGFLAGSAAYALTYNFPLLPRVHALASKLQKSLEDLGVTILSPAETCMIFYDASSIGSNYDEIAERGAALPEPLFLGGSRVVLHIQTSEAAVDDFINLLATIAEEKRKAGFVKPETQVNGHPDVYVRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKE6</accession>
    <name>A0AA38JKE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_119501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="705" mass="76059" checksum="BC7A51212DC2C763" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKH4</accession>
    <name>A0AA38JKH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_267890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKH4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="378" mass="42420" checksum="8CFE9A002D1DB306" modified="2024-01-24" version="1">MMCNRGTKLGFIPCTRGILRSTDEEKSFRVVNGRVAVLTPHFASNYLPDLHLLSASNFRLPSMAAEATPSHKLPTSKRFDSAEADMTLQSSDHVLFKVHRLNLEMYSQVFADAGGSTVGTVENEIVSLSETSEVLELMLQFVYLQPQPDLRTVEWEVMKELAEAVEKYEIYSAIGVCSQRMRECVTEHPIEVLLFSVRHKYTDMMNESAEATLDLPPYTMLSCLPSNVFAAWIEYQQNHQALLAKEFTRFGPSRPHRGVSASCEFWHEHYALIAAALANSLSREGPPRSRARLRAGSAGLASVLGASASVSIATGANATSLRSRCDGHKNVLLRLPEMLERRQDVGGDKCVDCKRDLTYWISQTERDWRDSRKFSDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM56</accession>
    <name>A0AA38JM56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_318216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM56"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="12">
        <location>
            <begin position="146"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3732276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="411" mass="46437" checksum="5D89CD02048ACDFA" modified="2024-01-24" version="1">MTSLSTGFRALPLPIIQLSLAAVLKCGQSFRWTAYPLKLDPEDASSPTHEYRFCLRDRVVCLRQTATNILYRTVQPDPQPNANQRELRDAETLLWLKDYFQLDVDLALLYEEWGSRDKVFLGIQDRFSGIRMLRQDPWENLISFICSSNNNISRITKMVQSLSKEYSPPLLSLPTPDGSGVEDTYHPFPPPSALAHPDVSARLRSLGFGYRAEFIHRTAKMLVETHGDSIQPQDSDEPSEQWLRTLRDISTEDARAELLKFVGVGRKVADCVLLMSLDKTDVVPVDTHVHQIAIKHYGMKGSTKGKMNMTPKLYEELCTKFVQVWGKYAGWAHSVLFTSDLKSFALHGLLEPTSPLPSPVKNRKKRSREMTDLVRILPTPPSTPSVSESATATEIACNLSPAERVKKRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM72</accession>
    <name>A0AA38JM72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="6">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Fructose-1,6-bisphosphatase, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_271959</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM72"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000008">
        <property type="entry name" value="Fructose-1,6-bisphosphatase, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="17">
        <location>
            <begin position="12"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="18">
        <location>
            <begin position="205"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3732995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="335" mass="36390" checksum="0183481CE0E078C7" modified="2024-01-24" version="1">MATESVPSSEIITLTRHVLHDQMRLGAAATGDLTLLLTAIQVTSKFIATNVRKARLINLIGLAGDTNISGDEQKKLDVLSNDIMVNSLRASGKTAVLVSEELEDAIIIEEKNRGRYCVVFDPLDGSSNIDAGVNIGTIFGIYKLRPNSKGSIEDVLRPGSEMVAAGYTMYGSSANLVLSTGSGVNGYTLDAALGEFILTHPDIQIPPRGKIYSFNEGNSMFFNPPVVEYLKSIKYPASGKPYSARYIGSMVADVHRTFLYGGIFGYPDDKKNKTGKLRLLYEAFPMAFLTEQVGGIATTGTKRILDIVPTSIHERCPVFLGSKEDVQDLMKFFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM80</accession>
    <name>A0AA38JM80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium-activated chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1074871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM80"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="176"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="808" mass="90963" checksum="709F956B955914CD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMF0</accession>
    <name>A0AA38JMF0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1087820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMF0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3726356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="495" mass="53592" checksum="2A553C8409EDBBD7" modified="2024-01-24" version="1">MASHNSCPASNDHDETTPLLTVSNTEAQQLVKRATPLPKAQIAALCLVRLADPIAFTQIFPYINEFIAFLHVTDDPSQIGYFSGLVESTFAVTQLFFIYYWARLSDRLGRRPVIMTGTLGVALSTMYFGVSSSILDLLICRCIAGVFAGTASVVHTVLGEITDSTNQAAAFPLYGLVWPIGSIIGPLIGGSFSSPASQFKTFKETIFERHPYFLPCFVAGLLSIAGFTMAYFCLEETLAAKQRPGEEKNYMSSTPEHNTHEPALATPSARELLSFPIIRALSLSGFALEANGTSFAVLYVLFCYSPIQNGGLAFPPSTIGYSLAFAGVIAGSAQVFLMPFLLRRFEAAKIYNMSITAWPVTFLILPTLNMIARYGLDESTGQLGTRSHSVLWIGIVVVLALSRVGGIAYSASMILIRNNVPKPSYLGSANGLVQAFMCFSRCISAVFASSVFAFSDKYNICGGYFWALLYASIALVGCSLARDITRNSKNMLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNI5</accession>
    <name>A0AA38JNI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1064117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNI5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="398" mass="42778" checksum="780D7373BA21A17E" modified="2024-01-24" version="1">MALKGIKVVEFAGLAPGPFAGLVLADNGATVVRIDKTSSSSSSDILCRNKRSLAIDSKTQSGVIVLKRLISSSDILIDPFRPGVMERLGLGPAVFLGKDGEVGLNGRLIYARIAGFPRTGSYKDMAGHDINYLALSGILSMLPGSHDRPTFPLNLLADFAGGGLICALGIMLALFERNSSGRGQVVNVDMVSGARYVSSFPLIHALNPSTGTFAGNRGDNLLDGGAPFYSIYSCKDGACMSVGCLEPQFFATFIEHFTKALPSDFKQQSGWVPHSSAQFDRDTWPKLKSFLELGFKTHTRDEWAAVFMNTDSCAVPILTPEEANKKEIPGQFAPLPHPRVLTMSNSDIVPLPINDGTIELSPGKHTLEILRELGFTNDEYQKLIQDGAIEGSGLKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP97</accession>
    <name>A0AA38JP97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1054840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000162">
        <property type="entry name" value="HAD-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="360" mass="38981" checksum="CDBA704B11D51868" modified="2024-01-24" version="1">MEGPLSFLVTFPLIRKLFNMISTFRADAVLFDMDGTLTDSIAAVEAAWGKVAKDIGQDPAYVIAATHGKRAIDNLAQFKPNILPHQMDREVQDFEESILFFADAYKTHGPGSRRSPPIYSSESAVDSEVNTPSLTPGSSAPSSRASSFAFDSSRRPSFASRLSSALMMSAVPEAEVVSPAEFEDSSMEGNHMDIVEQQWNDKSKVHQLKAWQIEAAAVDRSVRILPGVKRLIDSIPAGRYAVATSGAKTYAYGCMTRVGITPPPVTITADDKRLKAGKPAPDPFLLAAKCLCYDPKRCVVFEDSPSGIRAGVASGALVIAVCTSHERSKIENCGAHFIVDNLEKVKCDFIDGQLNFTILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPK2</accession>
    <name>A0AA38JPK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_146466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPK2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="108"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="262" mass="28231" checksum="93F920A3A7F69967" modified="2024-01-24" version="1">MSESSNVPNEQPASFEAAATVEGSSTSGGTGDDVRESDSNEPPAFKVYKPTSGSSSILPTDLPDSYFEPTALDLKLAQSQLSSRTQALTNAPLQLRTTREAAEKAKKERWPNTKIRVRFTDRTQLEKVFPSTDKIKSIYAFVRSSLREDVKPIKFILYQPPHRDLKVSDLKVKNLTLAELELAPSSVLLVRFEDESLNGSDVPAPLASNVLALAESLPAPPSQEDDSSSASQSATNKGGKTLGSGSAAGGKKIPKWLKIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPS0</accession>
    <name>A0AA38JPS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1018371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPS0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="235" mass="26665" checksum="0A3C94865749BF55" modified="2024-01-24" version="1">MSEGSDAADSSSRGRGRGRGRGKSRGGLGKYLRARGRGRGFGRSAEFTKRLLLEGEEDEEEEDEEEVAARREKYSRRRLGTNTDRYAEPEPELDSDGEPIVEPEVDLSAFLEKQKLTDDPGPSAPPPPEDDDDVDHSLDNLTTRKTNSKGKAQRIEWDESLEDLLREKAAAEATRELKNRFRAKSDKLRTSDRPKIRDRKKELSYVDAPPLPLLENERSKTEMEKMEDFLDDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQH4</accession>
    <name>A0AA38JQH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_518661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQH4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="9">
        <location>
            <begin position="43"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="325"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3736692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="500" mass="54490" checksum="C87FAA6ADAAEE0CA" modified="2024-01-24" version="1">MAPDSQSIDGLVQQITTSNNLEALAHTLRTSGTSGRDVREFILASSMSSGQDPLSVLDLRNNTLGVMYILSARLNIYLNAQSGVQRPPWAIVTQFCEIFDPEQARLAPERIVMLAKSLTRYAQEQGKLKLAIPLLYSLATRLPITLSTLTPIHHILLLTTLQARHITPEITRLLIEHPIDDLYMYSNIYPDHNLSYIDNLVYHYLGGVILTKTGNYTAAIDYFETALTAPSTTNSPPAGLQLEALKKLRLVQCIAMGGPQPLPKYTSPVLTRILKSTPYQNLINAFPGSLHAKDRGEGPSSGNNRLKQLVSKDRDFYASECNLGLVELLVAEAPKWVIKRLTETYVTLGLAEIGRYVGIDDEQQVRALVLKMIESKTIIATISDSGIVTFHDAPDTADVSVEDIRTLLGDVASGTNLTEISVPVLLEAVQVQSTHLAQLDMEVGRSKEFIAKAIKTGGGISSMSMGGPGSGFGPGGAFPDEDDYVAGMYANDREDTMVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR07</accession>
    <name>A0AA38JR07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_400615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="222" mass="25134" checksum="68B433314AAD8D3B" modified="2024-01-24" version="1">MPTERSKRFTLHNSSVKVSRSKGQLQEKEAVGSLVVQSAEPASESVTPLKKKDRQQQKREAFLQKLELTQSPYSRSHQRRLNRKAREQIGQGLDEIRDVLQSVDDGKAQTTIAQDAAKADKLQMKVDGDEDTLKSVQQSKAKSSQIGEGRASTLSDYQRKKALFVYHVTVMLVDMLTAVDRKIERLRHPFILSNPQFASNPFETIRTHAQNTLVKHVPTRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR33</accession>
    <name>A0AA38JR33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1113853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR33"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13882">
        <property type="entry name" value="CuRO_2_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041325271" evidence="7">
        <location>
            <begin position="18"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="159"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="373"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="523" mass="57168" checksum="8D41BFEA92043CE2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRP4</accession>
    <name>A0AA38JRP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRP4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="109" mass="12312" checksum="601C49CF1A9C074D" modified="2024-01-24" version="1">MHLSRICTLIPTTDIIHANNVILPPDDVEDDIQAHTEKIRQERQEKQAKQAEAEPALTREVTLGGSRKGENFPLVGNLIGEDYVNYILMYNMLTGIRIKVSISDDTDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRW6</accession>
    <name>A0AA38JRW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_988069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRW6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3737164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="236" mass="25740" checksum="681DF80F2B8CB04F" modified="2024-01-24" version="1">MDRTDLETYQVQLSQVEDALQAEPDNAELASLRTELQELISLTETALAQAAGAASLKVESSRKAASTPALAWSAGDECMAKYSADGVWYPARITSVAGSEQNRVYTVMFKGYDSTEQAKPSDLKPLPASYASTVSATKRKHETDEEKERKKKKNEKKLETRAAKAKEQNQKQATWQKFAKKSEKKGVHIAGVSGTSIFKTPDNPLGKVGVTGSGKGMTHVTQQSKHKFTPTVDDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRZ3</accession>
    <name>A0AA38JRZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADK-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1131913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRZ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="328" mass="36740" checksum="2DD6CB77F57F293F" modified="2024-01-24" version="1">MSIRTRPNPRLSAWSAAARSIASSSPASLFRNSLQPVAHDEAQSDSRNVRMLRMIMFGKPGAGKGTLSGRLVKKYDILSLSTGDLLRMHIQDKTEIGRMAKEIVAHGGLVPDELMLQVVTSKLDHLHNKHWILDGFPRTLAQGELLNTHLNKQNTPLSLVVNLDVPDDIILSRISDRWVHLPSGRVYNLSYNPPKVEGFDDETGEPLTKRPDDNPEIFARRLEKFYSTTSPLLDFYARLSQTRISPPPHRHPHQHPHQLAFHTKPPHRLMLQSISGTTSDEIWPQLETVLKDAFPGLKERVDSADIRRRHSLSDAIAAASVAASMPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS01</accession>
    <name>A0AA38JS01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1062115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS01"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="89" mass="9437" checksum="E62851152B45BFF5" modified="2024-01-24" version="1">MGSICSKPSTHSGGHTVLGSISDNNNDASRTNEADPRAAAAEAAERRLKASQMRGTHSSNPNRGKLAAQASKPAKVTPEPEQEERLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSW0</accession>
    <name>A0AA38JSW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_991543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSW0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20821" checksum="A963F752624DB277" modified="2024-01-24" version="1">MVVTTETRKKKKPPSFKHYPAARAKSLKKAWVEKAKIKSKWKSERQKMELPSSSLPTETGNASEDENRKSGTEFEDIDEGLGDERVETVVTPEPSAKPSRTPRPNPASTLQMKQTKDHNAQNLRDLTRTAYSRETLHTYKSDPLNRRGTANGGRGNGRGGIRGRGQPNMKLRMGAMLEKIKRDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT18</accession>
    <name>A0AA38JT18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1056014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT18"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="215" mass="22775" checksum="9ACEAF4E32E60001" modified="2024-01-24" version="1">MKGTAHIIHHGIGPAAVANAITNSALANAGMPMDTGEETFAEHLANVTANSGRLRTRSAHSAQLLQKKRNRRSALLAADAAFSRAFKNRSTTLSSSNKARHSAHATALAVKSPPEAHPTYATFALSSTSSFAGYTRGSTGSSRRNLIRDGNQEVGEQLKQTCADSLTGLTAHVAELSLQSEELECYCPDPRPVCGCAMIQKQILSIHFTMVGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTE9</accession>
    <name>A0AA38JTE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_383918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTE9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="194" mass="21787" checksum="720F094573A41B86" modified="2024-01-24" version="1">MIHAVLIFNTSGVPRLTKFYTPVHLSVQTLVQKIFSLVYARPVDLCNFLDAPELEPYLAQNEEEERWRVVYRNYATLYFVFVIDGAESELGILDLIQVFVQSLDRAFENVCELDLVFHFDEVHHILAEIIQGGLVLETNVDEIDDSVQLAAKLRRDSYASSNPLALSSGLNPRGANLHTPLGWLTGKLTGVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUF8</accession>
    <name>A0AA38JUF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1117896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUF8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="205"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="570" mass="65134" checksum="C486B32F9C57D03B" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVB6</accession>
    <name>A0AA38JVB6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_1050883</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPII-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVB6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="122"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="386"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="501"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="613"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3736795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="753" mass="84043" checksum="7226A11F3CC66577" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVQ9</accession>
    <name>A0AA38JVQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Syntaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_406783</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVQ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="300"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3737170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="363" mass="40278" checksum="F1EEE1ECA56FD2C6" modified="2024-01-24" version="1">MTAIQSVLISGYQERLEPKPHTVYQIEIRGHVRSWSIWRRYSEFDDLHTELVKGTGSPPPASLPPKHKYSILRSHSDPALLEERKTGLETYLRAIISAKEDKWREAFPFKEFLGIPIGRQAGVAGGPPTQFTLTSWLDEHQELQNRLRDVRADINKREALSDQGDVSASHKSNVSAKQKLAGVLSRIGTLGKGLTELAMNGMSEGELQRRTDMVARLQDDCEKLGKMVIVARQFNRSGTDPSAPYSSASTNPASASDREALLGTTNTFTRVTRVFGQPSKPQETEVTRPLDDVGVFGLQQTQMQQQDGQLAQLTTILGRQKQLGQAINSEINEQIVVLDGLANDVDRVGDKLSKASRQMHRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYJ8</accession>
    <name>A0AA38JYJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1060765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYJ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041230610" evidence="2">
        <location>
            <begin position="29"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="607" mass="65069" checksum="0C538EDBE6659A2C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQH7</accession>
    <name>A0AA38MQH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1008919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000120">
        <property type="protein sequence ID" value="KAJ3711436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQH7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="137" mass="15571" checksum="6CDB966F62C46D00" modified="2024-01-24" version="1" fragment="single">MGWTNSVPIFHDDVTYMLREEIPHVTRPYIDDVPIKGPPTRYETPEGSYKVIPENSGIRCFVWEHMQNVNRVIQRVKYCGGTFSGHKAVICASEFKVVGYRCTYEGRIVDPDLMGVIDRWGPCKNIGDVRSFLGTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQI0</accession>
    <name>A0AA38MQI0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1008882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000118">
        <property type="protein sequence ID" value="KAJ3711466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQI0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48260" checksum="7F2F048E3FEA3FF9" modified="2024-01-24" version="1">MSSSPPPPIDAPSLPLSHPLSLSQSQSSHLTNSVIAIAEEPLNDPPPPYPSSSHRTRLVHVNRGTRSTRRDSQQRQRSQVVPPTESDIHEPHQRSVIRAFAVEDPTEDAASETTPLLGGINSGHPESPSSTSHLRPRSLSQSSINSFAPSLASLAQTAWVFFRSVKMMKMMKEVKVVVNEEKNVKEKKSHGSRVDDHPMVRRMTMLTSATVARWARYFRPLTRPVYWRSLTHLVLVNFPFALAAWVYLFVFTVTGTTLLIALPLGAILCFFNLLGARAFSRAELFIQTRFHSPLHYPLSVLHAAASSPTTTITTTTTSSSPITHLIATYPIFTRSRHPSASELESGQAVVGEEVTEMSFYKNTYSMFTDPTSFQALFYFLVIKPAITLLFITFLLTICVPLLVLVIPAPVVLRVCRRIGRWQAVVAVEGLVIGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQP9</accession>
    <name>A0AA38MQP9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_892596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQP9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041331218" evidence="1">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="151" mass="16516" checksum="7A3874A9B83F844A" modified="2024-01-24" version="1">MYLSLACLILCFISSAFAIPLTVVSDVGFQTRSEPQPPGLIQVTFPHKANFKLQNAASVCDHIKQALRYATSVLPELQGLGVSCGNQYHPSKRPIPFTFTVPVSKHVKFCDPVCTGMILPTGSILISGRETIYEGNKLTQRWSPLAIAVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQU8</accession>
    <name>A0AA38MQU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_976288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQU8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17562" checksum="8A2E3B8EDA8BF9FE" modified="2024-01-24" version="1" fragment="single">VPSDRLEQINAFVTDTSEDLQRYDRAVIEMERQLVAIQNARDDLRRRFDNAQSLIASPIRNLPLEALSEIFSWCCWRDESSYSLSLGKEGSVSCPTLRLSWVCSWWRKCIQSSPDLWSSIEVTSSRIFHLNPSSIQLFRMYLSNSEKRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRC2</accession>
    <name>A0AA38MRC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_784920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRC2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="162" mass="17921" checksum="AABC076F52A65412" modified="2024-01-24" version="1">MSSALCQRGSSLSKVYPSSTLSTIQTRLISNSPYGRTHVWKRRPPVLPNPVVPKFPQRVIRADGTSFTHWTTSPRSLIRLTRDTTNNPVWNTALWADNKAVEDEANTTGRMGRFNRRFEGIGGAGGSVDWMAGTGEGSGIELEGEIVDPSLYVMKTKKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRL0</accession>
    <name>A0AA38MRL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1096676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRL0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3719651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="208" mass="21202" checksum="6808B9051A986294" modified="2024-01-24" version="1">MSYDSSLLASAPQATREMRQEGYNPYILDQEQKQKANALPGPVVGSGSAHDLASSKEYPPNPNPNEFAAQPKTPFYRTRKGMIIIAILAIVIIAAIIGGAVGGTSHKSHTVDSVNPSSLSSSSTSSPNSQAVQGAGTNSAGSATATITTTLTTVVQSATQPGGVIGDVTTTITSTVTESAAATSTSSADSNGVGNGLARGRRLVKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MT17</accession>
    <name>A0AA38MT17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_438143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MT17"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="329" mass="36093" checksum="97F91A2BAE7F2134" modified="2024-01-24" version="1">MIGWFSRKRHLKKRKDRPTESETDDCRSSSSDKVELANNTDPPLELQRKKRQKVSKTDMRDAIALVKAEIVDAIIPPSPRSTSLSPHTSSSANASHQVVQSSPLDLTEKNRSPQSAARVIDNNNDPPPVYTSSLSTDGFIIYQPAACVNVQQPVVPSALSAPLAIQPGLPLFDAPRHRINSTLTPYRVPPMHIPSTNTQTQIAAQYQNQLQPSFLPQPQHLMQAISSGPSHSYYPASFLQPPSVPLQESATTARTAQNYYPNIVASRSYASSSAPLYNLQAVVDPALHIPGPQHFQSPAILSSLLQPLQPSSSHLMNTSNVFQLQNYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTU4</accession>
    <name>A0AA38MTU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_141795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000138">
        <property type="protein sequence ID" value="KAJ3710505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="126" mass="14195" checksum="9E2CD2D25D9FF6E3" modified="2024-01-24" version="1">MSGRGILMEKYSINRNRRLLESAQPEGLPWGHTLNDFFWIRRIPGLKIMTMYSRSMIQEMGENAAGVEHPPEPQPTVLDPWPLLTLFSPDALTKASENSTDAEVEIHCASEAANRHTEGKYVISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUF8</accession>
    <name>A0AA38MUF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_970163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000131">
        <property type="protein sequence ID" value="KAJ3710875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUF8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="197" mass="21123" checksum="7B329A4A633A5B9A" modified="2024-01-24" version="1" fragment="single">YGPSSSAEGTGYHYSTGTEHMGSSPTSIPRYQPGQYLAPINTGETLQLDEHSTLYMQSNPSTLSYGQGQNAQSLNNSVSEEYYALSPVVASNPGSAHSYASHSFTSAGYSSATGLRNLPPPRSRSPTPAADDEDYYVVGNDSYHYTGGLHDPEKANNYDNYSSYGSQYAYDSSALPTPIEPITPVETRHFGPAPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUK7</accession>
    <name>A0AA38MUK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_995880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUK7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="254" mass="27398" checksum="6630C4A6EE76DD2B" modified="2024-01-24" version="1">MSLKGRIALITGCSGGIGAATALALVRQGCSIAIHYNSAKEKAQALVQTLQAAFPGVIAIIFQADLSDYENVRRLHSQVVDQMGHPDILFNNAGGTLKTIGRMGNIQDMSIEDFENTWRLNTGSSYLLTQLCIPHMVEQQYGRIVFNSRQYTIQGTGGVIGPHYASSKSALHGLLHWIASRHAKDGITCNAVAPALIVETTMMSNPTDEMRNMIPVGRLGVPNEIASIVELLVTNAYMTNKIIVADGGWTPSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUU4</accession>
    <name>A0AA38MUU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxyneurosporene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_882522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041462039" description="Hydroxyneurosporene synthase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="3">
        <location>
            <begin position="231"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3714320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37090" checksum="F2C6A6E87C6072DF" modified="2024-01-24" version="1">MFFQSLLSLALVPTLIHATTVTFPPTVGLGTSDVQYISSSSTFDSLKISNVNSTTYEWYYFDAISDDGSYSVVATFFVAPNTAFPFTGSPTMTLEVLLSIQTPDSDVFYLNGVFATSAQVSTDGDGASGVWEGTGLSFNGSSDMSSYQVVIDSAASMGVTGTISMQSIAPAHYPCSANEAGATMQLMPNVGWANAIPDSQATVQLEINGQNISFTGSGYHDMNWGDIPFENAVSTWHWGHGRLGPYSLVWFDGTSQDGTPYTSGYVSMNGAIVDTQCSGVNVTATSSGFDIEIDLADESVFQAQFSTDHTLLSFDGVYFRWSGGLVGGISGGEQYTGSAMFDEFDFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV43</accession>
    <name>A0AA38MV43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1101374</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000080">
        <property type="protein sequence ID" value="KAJ3716258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV43"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="215"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3716258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="312" mass="33539" checksum="4C1AEE15833A498C" modified="2024-01-24" version="1">MAAVKKGKTPQDFAIDFMMGGVSAAVSKTAAAPIERIKLLIQNQDEMIKQGRLSHPYKGISDAFKRTSADEGVLSLWRGNTANVIRYFPTQALNFAFKDYFKSLFGFKKNEGYWKWFAGNIASGAGAGASSLLFVYSLDYARTRLANDAKSAKGGGERQFNGLVDVYRKTIASDGVAGLYRGFVPSVVGIVVYRGLYFGLFDSLKPVVLVGPLEGSFLAAFALGWVVTNAAGMASYPLDTIRRRMMMTSGTGQKYKSMFDAGRQIVAKEGTTSLFKGAGANILRAVAGAGVLSLYDKAQELMFGKVYSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVT9</accession>
    <name>A0AA38MVT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF427-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1103608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVT9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF9">
        <property type="entry name" value="BLR5716 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="254" mass="29142" checksum="2BDB2603AA92026D" modified="2024-01-24" version="1">MSAVPTFVPPELGNTHIEDCPKRVRGFFGGVFIVDTRKAKLVWEHKWYPQYYFPNSVLPSKFLDDGSKQVLPDGPTRYDILVGDERAPGAVLVYGSSNGDLAGLFKIVYSSMAKWFEEDEQVFVHPKDPYKRVDVLQSSRHVRVEVHGVEVANTHKPRLLFETSLPVRTYIPQTDCKLELLVPSDLQTSCPYKGVASYYHVQTAPDRRADNVVWWYRNPNVECAMINGYYAFYDEHVDVWVDGEKQPRPKTHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW31</accession>
    <name>A0AA38MW31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_848159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW31"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="203"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3715309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="348" mass="38489" checksum="CE17B7CAE41B905A" modified="2024-01-24" version="1">MESKRVRPVLFPLASTLLMMLEFLAMLTTLEDSPGIDMSAIFAPFFWGFFVSIFLGGITIVQAYMYFPHPTDARSVQVLAASMLILDLISSALVAQSLYYYLIPHFGSTEPLRTITPELSADCLISSILTVTSQMYFVYQIHSVKHDGILAWTILVVLTLLAIITFVGGIGCVATMYVFAYGILADRSKDFAIFFGVAKGFGAVTDILATIAMCTYLSNAKTGFSTHTDSLIKGLIQYVIERGAVVTLIQTLLLITFYAAPNNLYWLAFHINVTKLYANTFFCMLNARKSLWKKHAPNNSSMLSSNGIDLRTTRFEGSGKSYALSSLQREVQEPEMPTITKSVVISEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW85</accession>
    <name>A0AA38MW85_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1095759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000061">
        <property type="protein sequence ID" value="KAJ3720768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3720768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1325" mass="143034" checksum="6D1699E7407C3F0B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW99</accession>
    <name>A0AA38MW99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_980232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW99"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3719076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7631" checksum="63DC61464EBF3A29" modified="2024-01-24" version="1" fragment="single">RYSMLPALTTDGIIYSHIKLGGYSGDEFLTWLSGLLEVMNPYPSPCSVLILDNCRIHHVEGVEEMCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX07</accession>
    <name>A0AA38MX07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_692245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041405050" evidence="3">
        <location>
            <begin position="18"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3721369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="518" mass="51674" checksum="B3D671CF388E3851" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXP8</accession>
    <name>A0AA38MXP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear condensing complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_989036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXP8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="573"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3736799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="889" mass="100287" checksum="0E041F96419D32FD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXW4</accession>
    <name>A0AA38MXW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_681311</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXW4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="365"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="752"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="863"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3722111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120134" checksum="5B3D1863A575638B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXZ8</accession>
    <name>A0AA38MXZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7708 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1088492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXZ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="107"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="542" mass="61894" checksum="1FDF92CEAE7C31BB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYA5</accession>
    <name>A0AA38MYA5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_471888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYA5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3729947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="168" mass="19043" checksum="9C1B6D187772596A" modified="2024-01-24" version="1">MLIPVVESHPRLFTTEEDSRKLKDRVKALRVETDRIPEESRLDDYCNWWNSLSDFVGILEGRGEVIQRICLEGGRIFRPCSMLWPDHSTYSLYPADVLDSMLPDPTSLEDILLSCLFSAHTEKTLKHASSFDLRLSAHLAGITEPLGLRDAELDSESHVYSSILLVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYU0</accession>
    <name>A0AA38MYU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_537296</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYU0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF9">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041297586" description="AA9 family lytic polysaccharide monooxygenase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3728063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="348" mass="35508" checksum="1CB9C179A3E95468" modified="2024-01-24" version="1">MYYSLVAAACFIASASAHATFQDLWINGVDAGSSCVRLPLSNNPVTDVTSDDLTCNVTPTPSSGVCPVMPGDQVTVEMHQQPGDRSCADQAIGGDHYGPINIYLASVEDATTADGSSASWFKISEIGLPSDNPDYWGTEVLNDNCGHYTFTIPPDVKPGNYLLRAEVIALHVASSVGGAQFYMSCYQINIGGTGTASPAGVSIPGAYSATDPGILINIYQQLDSYEIPGPSPYGTTSPTVAATPWPTTATWNTALQPSTVPTVVPTSIPGGVPSSSSGNSGTTAPTTTPTTVAPTTTTPTTSAPTSTSTAASGAYGQCGGIGWTGPAACVAGFSCVVTNAYYSQCVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N017</accession>
    <name>A0AA38N017_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_427174</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Plastid</location>
            <location evidence="14">Chloroplast outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N017"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF135">
        <property type="entry name" value="TRANSLOCASE OF CHLOROPLAST 120, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1002">Plastid outer membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="G" evidence="16">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="229"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3731417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="400" mass="45992" checksum="BEF53FB5D0BE254C" modified="2024-01-24" version="1">MENRSKSADESQDEVVIALMGNTGTGKSSFIKLLTGDVNVRVGDSLDSETDEVVKISFIDPVSGRTVVLVDTPGFDDSRDGRTDTEILRKISEFMISEYDQHRKLNGSIFFHRMSDPRFGGQSRRSLRIFRELCGAATFKNVVVLTTFWDRVNEQEGLAREEELKSNSNFFKDLVDGGARFMRHDRENSGARQVLDHIFTLVPTTVQIQKEIRVEGKSLEETAAGSAQREEINRMVAKHRKEMDDLNSEIAAVKIGNDTLKRELQEERAELQKKLLRWEDEKVDLKKGLDDESKLRKRLEEEIKMQREKYEKAQQELQSELEKSKKERNEAFLMEASRKARNAERARIEAENTLERRMSFKQMGHEIARGIPLVPTAFAKPVFGTIGRGLDFFDRRKRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0G4</accession>
    <name>A0AA38N0G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-P-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_996231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0G4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35491" checksum="FCAA3352DA1BB439" modified="2024-01-24" version="1">MKEKFDLHHDLVDLRGKIIIVTGGNRGTGLATVKHLAQAGATVYMAARNEAKAMEAIEKLNKEGLQPGNGQVKWLKLDLSDPRNAKRAAEAFIEKEKRLDVLVNNAGVLSGPFEKNTDGLSTMVVVNYISPYVFTRTLIPLLTATANEVDSDVRIINLASIAHRFTPSIVRFSQIEDLNVEYRGRIMSGFLRYAHSKLLNILWTRALQKYFDAASPPIPIVAMAIHPGGVDTFSHTWPLPWFWKPIVALAISDPEHGSYTSVFAAAAKVVRDEKEKYKGAYLDNKPVGKIEVPSKAARDDELADNLRRLTEDLLRSFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0N9</accession>
    <name>A0AA38N0N9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1070584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0N9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041334115" evidence="1">
        <location>
            <begin position="18"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="551" mass="60335" checksum="A3010631B889850C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N178</accession>
    <name>A0AA38N178_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1132018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N178"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="404"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="577" mass="60971" checksum="34C0E3758CB0BD88" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1R3</accession>
    <name>A0AA38N1R3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1069926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1R3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="218"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="425" mass="45848" checksum="F161AAA7E94CB043" modified="2024-01-24" version="1">MNFIDLTSDSEDENVGTSSKELKTIDSDESEIEIISISSVKPSHGKSKSSTRLALKPASLHIGTGSDSEVEIEVVQMTPSKPRGRNHNISHIRTPGPNSSGSSSTTKSPTFRDSTNHLGQPVSLLSTHVKSKPGPSRPKVHSDRSLKSDERLARKLQAQDQKEYQKLIKGITTKKEGIVFRTVINADGTLEDGSPAHPDDLARFEPWKKLFETTSGTQVKRFHWIVNYELEKRFQEIKTLLSDSADATDDPTKELLLFHGTGTANIDSILNGGFRIGGVGSHRVVNGTMLGFGVYLAASAATSIGYAAGANRIFACRVFPGKITGDLTYAKTPPKTKDPLNEPYQTYSATFGPGIVYVVRYACLVLPCYMIEYDLSYACRPGLPGTSLGVNMTGFGRGGAGVGALALQSIAVPPPVNLLHRSSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N248</accession>
    <name>A0AA38N248_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1066300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N248"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="110"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="411" mass="44739" checksum="1C2B0B26C2DA55E8" modified="2024-01-24" version="1">MSNARGASLSGSDLTAQLQHNGRAVEAHIDLSERIKIVSGRLVYVPPSANSDVTSPPSTTPVTGNESTASRPGSPGSPPPSYEDSFAEQFSEFKSSHKSSYSARSSSYFKFSLRDKPLRLVGSILHAECRRAGQREYVHSELDLNSYIGVIDGQLVWGREGFFSISQDVRLEEFILHAECKNESGTTSHSSLDLSRYLQTYDGVLGVKVATDTTEISTLFSEASWMKFKVVTEPDPIGVLGTLGDQAAFKTAFSSLATTTTEHVVAEMTQELSVAAAQYVKSAVTDTVKAKMTEIVTNAVSARVREEITKKVDEAFAVARESVLKACYDMADEAANDVTIQYTQSVVGPMEDKITESCNKLVEYALREVSESAIGQFQERAEILMEREIVGAGIRRAATQARLLKILAATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N373</accession>
    <name>A0AA38N373_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_769486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N373"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="118" mass="13475" checksum="D597EA3A60E47387" modified="2024-01-24" version="1">MHLLFVLYDIALHADVCVMLFCLFCFLNSGLSRISSLSGLSCLLRANFKPLLFCRTSNFCLEPINLMDLLPLLSPLQLTTKSPLHCHPLLRTIQFGLKPLTVWFPFHVELLFLLLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4E3</accession>
    <name>A0AA38N4E3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1055239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4E3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3735947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="363" mass="39670" checksum="C564AD93CE6384D2" modified="2024-01-24" version="1">MGIQFGSFNSVCETAALVICPLVGTDQGVEPTCYSRNVDVGGTLIFQPSTCFVHIAAIIMTIIMILHIRSKYTAVGRKEIIMLFYMYLVISLLAMFLDSGIIPTANVAYPWFAAIYTGLIASAYCCLLINAFVGFQFAEDGTPLSLWFLRIACLVVWAVGFFVAIATFKQFASFSYSKPIGLWIIYLIWPVVCVAVYIVSQLILVFRTLEDRWPIGDIAFGAAFWVIGMVLLFAFSDTICNAIEHYLDGLFFQELCVLLAIMMVYKYWDSITREDLEFSVGSKAAVWEVKDPLLSGSAGYPGGSSRGNYSEEDVGSNYGGYAPPPSFGNNKTASLVGGVSGAQLYDRKSYGAGGRGYPPAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4P5</accession>
    <name>A0AA38N4P5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_406223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000157">
        <property type="entry name" value="Alpha-1,3-glucan synthase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000114">
        <property type="entry name" value="Cell wall alpha-1,3-glucan synthase ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000162">
        <property type="entry name" value="Cell wall alpha-1,3-glucan synthase mok12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041240432" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1906"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1940"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1964"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2000"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2032"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2066"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2109"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2150"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2179"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2220"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2252"/>
            <end position="2270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2301"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="67"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1630"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1740"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1842"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1654"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1761"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1842"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1858"/>
            <end position="1870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3737161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2328" mass="259606" checksum="86A257937294F41C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4Z9</accession>
    <name>A0AA38N4Z9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1148735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4Z9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="366" mass="38938" checksum="A6C9C1AB169A49E1" modified="2024-01-24" version="1">MSFQALNFSAPSRSSKTRISKKGIGLGINVVAASMLSASSSAYRHMKSQEFSSSSSSPKPVKTRPRSSTTASTNASRPASLDVSNATVNTTTGHSQPDTAAPLEEDLSVLKALWTKPAYYEELHTLSAYGELPVSLCPLPLSPHHAAIATKSNLDNLPSQTSEASSPGRLPTSLAARLFEVAKPPAMAKRRRYTVATSRPSLVKVKEKTCTLDSDGAQSSARSDGLEYVKEEGSSSIIDPARPNDNPITATNLMKQELHPLPLRSSSVPCEPLASCSVAVELQTLSSNLKLSSGEDVLVPLTSASSATPTTPATSRPPRGVNVNVRYIKHYPYMITELANPPRTGSGSEAEEDGVLSRTKYCLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5C3</accession>
    <name>A0AA38N5C3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="11" type="ORF">DFJ43DRAFT_1129183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5C3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="38"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="76"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3737058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="296" mass="32836" checksum="A78998BDBF32A2B7" modified="2024-01-24" version="1">MGTNYVFSLQPTFTQGLILGQLSILALLVFVLKYLFMDSTKYPFETTTYHPRINSDSIMRSQKLYQATNENGHKNEDESAEWLNLLLHQIVGTYRSKLQDDLPGAEGDEVARKRVEDYANKIRPASFLDHIVVHSVDLGSSAPRLSNGRRVPPSQSSNSPEIEFDVNYVDTVSVSLSTSYLFNYPMALFARLPVALTISLSLFRSSVTITPPLHTSPAPTLTFSISPTFTLDLTTMSLMGSRAKLANVPKLHDLIQHQVHRVLAAKGVWKVVLPGLATVEEAKQEVKNEMADAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J191</accession>
    <name>A0AA38J191_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="12" type="ORF">DFJ43DRAFT_1044604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000139">
        <property type="protein sequence ID" value="KAJ3710366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J191"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="131"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="367"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3710366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="484" mass="52359" checksum="E4BC16747DDC15CA" modified="2024-01-24" version="1">MSEENTAKEWILDAETEYRFELDAGTSLAITLVRGRAEIFGAELVERKPYLFGSECKAAVFTWVGCSPSTEYVSDETPMSAYGNLHIAFEQMRVKALAKLHGSPVPEYAHPTQSKTQSDFSAEPPRVLILGPENSGKTTICKILVNYAVRAGQGWSPILANVDPNEGGWACPGALSAAAIHGPIPTCSPANPLGSAATSAPATLSSNAILPLVYWYGHAEMKRNSLLMDRLIRNLGINVQEKFDQDPEGYTAGIIVDTPSSFASSSGLGVNDHRQKLIRACIDAFRINIILVVGHEKLNVEMQRSYGSLLTVLKIPKSGGVVELDHGYRERIHKYQMHAYMYGEMIPSPPGIKGGTQGGDTLTDFILTPSSNVINFSDLTIYRIGAETMAPSSALPIGATRVVSEMQPVLVDPAQPGSGLLNAVLAVLAPYHPDENERYDEELLDLTVLGFIVVYPSQENDCSSPTQGSLVGKTAIVGSYEWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2M1</accession>
    <name>A0AA38J2M1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1160994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000095">
        <property type="protein sequence ID" value="KAJ3713975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2M1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="203" mass="22249" checksum="A54447C4169D6ACB" modified="2024-01-24" version="1">MSSLPATEPIPTFITARIAARPRVIPLYATPILNRPRRTLSIHHVLPAKPYARAERNGLESPALTAVSSGSSTESGATANVGDLLSEPRLILIPPPNANVTVKSSGWHAASAKEYRKFARKAVDMYLDHKVNLSSQDSAALERAREHIEQAVPFFKAHLKHWGADTLLREQLKSKKDTIAKAEAKGKGKGKEREKSDEEETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J336</accession>
    <name>A0AA38J336_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_839569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000082">
        <property type="protein sequence ID" value="KAJ3715889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J336"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="244" mass="26720" checksum="EE6F77915697DEB5" modified="2024-01-24" version="1">MSDTSQDSVFLVHVGQVIYWNVASLIVTCIAYGFNLLAASIAVYLFVKNGTRGVARKALLTLTLVIMLSTTWDVINRAGLYLTQIDYILMRPLSGGILAQAVAANQATVPYEYVDGWPVTINLLIGDGIVSWRAWAIYPHNILVRASLIILMLANTAVNISDVIMEDVNPSGQTHSLAMDTASVWVSLGVNAFATSIVALKMFRHRRSSNLAVHFVPFKFSSRSLTHSTCIKPPPQTLQSKSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3J2</accession>
    <name>A0AA38J3J2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="3">SDH assembly factor 2</shortName>
            <shortName evidence="3">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1134525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3J2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3716805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="161" mass="18526" checksum="8A79797038235B14" modified="2024-01-24" version="1">MATILRFVSRARRTAQSSFAPSRCSIFTTARRLADPWPLPGSPEHLASTETPSDEARIQPLERPNESLGTLRARLVYQSRKRGTLESDLLLSTFARDNLKNMSEEELKQYDKLLDEPDWDIYYWATGKRTPPDRWANTALLEQLKVHARNEGKVVRRMPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3U2</accession>
    <name>A0AA38J3U2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1007344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3U2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3715241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="172" mass="19762" checksum="E1DE8BF261F13817" modified="2024-01-24" version="1">MKDKASSRHLPVAEISRYEPDCAFCNVSVENGFDVIWESDRLIAFRDRDPACELHFQIIPRLHIPSVRQLEKSDVEMSRHTIHSSKSKIVISFHADLLDHQSRMGFHIPPFNSVGHLHLHVQALPYKNFARRVKYPAAPGFKSFHKGFSWFTEANQTILILQQGRSVGIFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J403</accession>
    <name>A0AA38J403_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1206956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J403"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3719072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="145" mass="17058" checksum="5E5FCA912E74CB0C" modified="2024-01-24" version="1">MRLIIPSYLVIFVFGVFVIVRATPVNLPRTEPTLSATITITYNNGQEALQNKALDDEIHEHTKKLLEQEIPKNYHNSQIWKVYKDKVDYHFVNHYKEKPRVVEFHAQAEYQENGKTIKTMMFDKAWMGWGNMNNEIIGNLGNFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7C7</accession>
    <name>A0AA38J7C7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_890887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7C7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041448901" evidence="1">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="213" mass="24137" checksum="31DEC8E02048BC4E" modified="2024-01-24" version="1">MHLRPHWLKLVAVASLFIVAGAIPYDRSKYSNNVSRDQVPKLISSNASSLEKRGDAAKQAFANEWYNQLDREDWINYSPGFVCVGYGTNQETFLRNDLTAEIADRKSFVKIGNHNRGLFTLRKRKDSIVKIVEIEGLESQDAACEVQSLRDFGREVEAGFTTLTGERVPVGVIIMKRVSGVAIWDTPKWKKLKAAKRLDYMNSLRPKVLQTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7U9</accession>
    <name>A0AA38J7U9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1083600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7U9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="417"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="703"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3729133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="968" mass="108887" checksum="6AEB5297D7BFB668" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8L9</accession>
    <name>A0AA38J8L9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1040118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8L9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="19222" checksum="34FB7935B1E35239" modified="2024-01-24" version="1">MTEKSFSIGFEIQDSMANAKNAEIIKHTEITQVNLPRMRSGRIIDAALKDLGAGNEHLIAHFIDLDFFNQHYAVIRNVDRLCEQTNALLKKKKVEEYKDFTIGDPKFQHPIVIEDDLDWINTVLLYLTLINQPGSDVPVLDPKQLLGWTEIFQEMTWKRKRGELKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8R9</accession>
    <name>A0AA38J8R9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1106331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000108">
        <property type="protein sequence ID" value="KAJ3712534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8R9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="145"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3712534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="589" mass="65710" checksum="547365F181EC6AF5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8S5</accession>
    <name>A0AA38J8S5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1224647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8S5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="618"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="574"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1123"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1141"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1169"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3731677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1185" mass="126937" checksum="A8755CFBACB801CE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J947</accession>
    <name>A0AA38J947_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_751822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J947"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="104"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="596" mass="67127" checksum="E0C0B096EA788989" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9L8</accession>
    <name>A0AA38J9L8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1141223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000061">
        <property type="protein sequence ID" value="KAJ3720741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9L8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="124"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3720741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="393" mass="44230" checksum="8A7405EC43DA8812" modified="2024-01-24" version="1">MSLKNRYSTPPRLDESKFGVLSLPQYVWMKVKLMVTPLVIAREILLSPFVARSKNRPLKRIIGDSAFRFLADYFSGPELQQVLGTSVGVYSTWARKENLPITIEELEDGGRLMWIGPKTTEKMLLYCHGGAYIFAVQIFTISFWRFIQLQLEKRGLKVGIAIMSYSLVPVSQFPTPLWQTSRALQHLLSVEKVKPSNLVLVGDSAGGNLVSQVLSSMLHPLFDPPIIPNGTRLRGAYMMSPWISLTGVYTGEDSTNNQLLPSFTENNHCDVVGRDALLSWGKTVLEGAPNPTTTDYPYLEPINAPYNWFQGLPDVAERVFVSTGGGECLRDADRLFFEKIKPFHGEAEFFEQEGGVHNDPFFDFQVADGPLGGKRQSLTPKILEWVWKCFEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9V4</accession>
    <name>A0AA38J9V4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9V4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="863" mass="91473" checksum="A827D2BD81D5EE27" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA09</accession>
    <name>A0AA38JA09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1004495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA09"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3721385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="283" mass="32789" checksum="5FAB896E883936F9" modified="2024-01-24" version="1">MQGRNLAENEVSREEAENFAKIYKANPLARPCTVDDFRYWLAGGPKSEWNQAASYIFVEILEQKRFITTPDASMCDALREAFHVRLKSLHKTWLDKLKMEVDADEPYTGRPKTWQRKYTLFQRRRDVVITIPALNPYLEDFDQLGAGGMSSDEEDPGMSKPSMAYNIREPKWRSEEVKRWLRLLDFVHLESRCSTEGYQFRFSRGAPPRLRVDNNNKTSTARYVRGLPSNFYDAGWLEAMEPGWSKSGTGFVNLVIRPKNSRKLTFPEDLSRCALSFATSDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAH6</accession>
    <name>A0AA38JAH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-reducing end beta-L-arabinofuranosidase-like GH127 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1133814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAH6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="1">
        <location>
            <begin position="424"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="646" mass="71544" checksum="46BEA965DBDBFCDD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAL4</accession>
    <name>A0AA38JAL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1132406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAL4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="78468" checksum="C9641D4995B96150" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAU0</accession>
    <name>A0AA38JAU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1155255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAU0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="460" mass="50905" checksum="94EED78091584274" modified="2024-01-24" version="1">MSSVTNIPFPTTLAYYGAGIIGIFTLASFTMKKILGCIPWTPSGRDYLSVEEGEELRQQLSRKEVEITELRSSLSAAEDRSRRTARELEVSRKEVEAEHVNRTRTDSGKMAREVLGGKEALEHELEIQVKELAASRKDTNKAQEALAQMKTSLSIQSAELKVAQTFQSIPDRYAGADVLGMIETLNSEILRTASIMADVFAPDLQHPGTVVGDNEAGKHEAAMDTEAILGESVTKMLQTFNHQEENIILQIAFQALMVELVCRKHTSSCEKQRNSPCLQVAHFDSQICPPDLSTIKQQDLTYRILAACANILIISGLHESEQRLLNRLAARFSDRLTLIVERAMHLNDVIGDDITSCEFVPIYCFPAVPFEPSTMENATDNGSPGGGYEAVFVPNENKILCTTDLGLLRAEKVQGEERTWDNTVLLRPKIVMPSGLTISPTSSESPDWKTPSFQGEQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAW2</accession>
    <name>A0AA38JAW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1101663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000082">
        <property type="protein sequence ID" value="KAJ3715902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAW2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="214" mass="24073" checksum="368057D7E6BD4878" modified="2024-01-24" version="1">MAEPLSEADLRQRAQAFFARISAPGRVPELKLQPDANQTSQLSTRSPSPYDYHMPHELQPRSLIFSPSRSDNMQAVQDEYIVRLLARPMIRKLFSTDDPGILNSLDAAWAAFLCVMDLRVTNENDIQAAQRQVYNIVCQLATLVLFPITEKQLTQLLSWKILAPRSRIDAAPVANILLGSTSAAELEDAYSRIQKYHNSECESLLDLRFDSLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB56</accession>
    <name>A0AA38JB56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1090161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Preautophagosomal structure membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB56"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="36"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="165"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="263"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3724992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="366" mass="40912" checksum="78378B46C2FA89DA" modified="2024-01-24" version="1">MSTYGTTRHHHSPAANFSNRDRATDYHTTLFRRLTWDGTVPLEIRVDPKELPANSDRNLECYFVQAPRVSYLPLLMPEIRRFFMDLVFDETAAKDLKDEEWWFETAEGTLVKWHWPIGLIYDNHTISASLKPTSSRSSTNAIPLRLILHLASPPNEKLLLSPSPEACKQAFMGQLKEADFIRWGSTKRMTGLRQQDQDGLWEGIKEHNFDDYWRVASKVTPTTAPTRAQSPVPPSSSASMVNRPPSADPGGPSERDGAYNVRSIPVRLYVPDGPVIQGLVPPMIDDNTPRTLSHYLLDHIPLLFPASPPVPPPSRANPHPRPPPVPRPAYALVQGIVMPLETEMAWLGGCLAGADGWVNVCIGINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBD0</accession>
    <name>A0AA38JBD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_794991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000073">
        <property type="protein sequence ID" value="KAJ3717600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBD0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041303787" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="111" mass="12688" checksum="14E00FF32CFE4535" modified="2024-01-24" version="1">MSPLLAQMELLFVVPLWLIMPPVNWRNLQHWVVKAVQPERITIEVPEAPDEVPSVGMVAVTQGCTRKGYTVLGSMMGLQRSFRQRSLHAIWVSLRSAKKKEVPERRTEPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBW5</accession>
    <name>A0AA38JBW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_994209</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="240"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="247"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3733912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="424" mass="49580" checksum="91E05C14623F0076" modified="2024-01-24" version="1">MSDWTTDSNECLSISMARSVEDKKTLSEDERYENFHPAFTYPIFGEEEKIYGYKDLIIDLKFASGSLKQYLSVKWSDKLQSVDTVDNVDGTMREFLSEGIETNEDAFRSQVQEDATSFKPSGKMIYSYTRSASKGKGKSFAAEQPSPEDEDTVVYEVYHNTWETPGFKEYHRKMQIFILLYIEAGSYINEEEDAWEFVVLYEKRKRRDSPHILTYHFVGYSSLYNFYYFPEKVRLRLSQFVILGPYQRSGHGSELYKAIYQYVLSQSHMGELTVEDPAEAFEDLRDKNDLKMLLSTKQFMEEGFGQDSHSHSGGRVGKVGKALKSLSKGKMGPPVEKGWAEKWRVKLKIAGRQFQRLVEMLIQMHLDPLDNRGLRAYRLQVKERLYRFNFEVLAQLEKEERLEKLEETFQSVRDDYGRILKLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD17</accession>
    <name>A0AA38JD17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1144784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD17"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="720" mass="79132" checksum="69E3F1879C42032A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDG7</accession>
    <name>A0AA38JDG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1059700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDG7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041278881" evidence="2">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="165" mass="18717" checksum="0A06731112E1C356" modified="2024-01-24" version="1" fragment="single">MPVYLSIFVLAHLFQFVMAIDAVYAQNMLQFIFLTVFNALFLIYAIIQIGEIREIVVTCDSSAIPINVLTTIIPIVISIAELAYYIGLGWKIYNKFGCVGAMVYFVYKLVKVFISRMSARFSTIIIVVDHRDTLEASALDSSMYVITLVYHPTHIPVEGKIYFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE82</accession>
    <name>A0AA38JE82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000082">
        <property type="protein sequence ID" value="KAJ3715918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE82"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="84225" checksum="3640CB7A2BFEEDE7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEJ1</accession>
    <name>A0AA38JEJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1161380</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000106">
        <property type="protein sequence ID" value="KAJ3712746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1314"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="525"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1059"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1117"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1060"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1073"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1174"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1186"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1283"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1312"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3712746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1441" mass="152773" checksum="2CBC12CDFB3E6833" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEL5</accession>
    <name>A0AA38JEL5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1161271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000103">
        <property type="protein sequence ID" value="KAJ3712994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEL5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041308315" evidence="4">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3712994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="207" mass="24066" checksum="C73233847A5F1F66" modified="2024-01-24" version="1">MRLTLHSLTFFLVCLLTVTNISRLSLTWRHYGKYRRILRNDYSYIEDDYPSEIPMLKYPAAMMFNETDHYDLFSTEEWRTLIPKGHGWVHLGSQRRPFAVTMYHQFHCLLSIRQALEDVILNQTSQYEAGHSSHTNHCFSYLRQGLLCKSDTTLEPTTPVDLPGNKHGAAASGSGVLHKCMDWVKVRNYVEDNYSIFAKEVGWDVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF97</accession>
    <name>A0AA38JF97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1159435</name>
        <name evidence="3" type="ORF">DFJ43DRAFT_1159444</name>
        <name evidence="1" type="ORF">DFJ43DRAFT_1161929</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000126">
        <property type="protein sequence ID" value="KAJ3711078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="87" mass="9256" checksum="8F1D22739A2D4DEE" modified="2024-01-24" version="1">MPTTFSTLCLYDAQSDCSNIIANPPGISTSNSTMLNSAIHWTGTGTAIAIPDFLGTALDSRTSSNSSNSIWTGGRGKYREKLQFHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFA9</accession>
    <name>A0AA38JFA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1157378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3725642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="348" mass="38483" checksum="8E87F7A07824FD53" modified="2024-01-24" version="1">MPAKKLILVIGATGVQGRTVISSLLEPREDGSPSPWSVRALTRDLTTDRAQLLASWGVELFQGRVDNNLDLIAAAFKGSYGVYVNIDSFTVGQRIEIYAGIKMYEQAHNAQVKHLIWSGLDYASKLGNFDPKYRLAFHFDAKGIVGEFLKAQPSSPSGDSLTWSIISTGPYLENLFGPLLGPLPKRENGVVVWALPTGDGHIPLISLQDIGWWARYAFDHRSESSGKELKIATEMMTAAEIVKSFTRVTGIPAIHRRVSIDEYLATYPGRFSRPMVSGEPDGFTIGDTYRGVYTLMGDNIVSRDMEWIKRVHPTGDTLESFIKEQGFNGNLFTNFTLLNASHLHAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFV2</accession>
    <name>A0AA38JFV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_605201</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="44"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3736297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="373" mass="40002" checksum="03EB7E6302EEF1CF" modified="2024-01-24" version="1">MLPSRSLAGIKQRAFMRSQAVRRYASASPTAAFAGQKGSNGKYTVTLIAGDGIGPEISEAVKDIYSAAGVPIQWEEVSVTPILKGGKTVIPDSAIESVKRNTVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCISIAGFKTPYDDVNTVLIRENTEGEYSGIEHEVVNGVVQSIKLITWEASERVARYAFYYAQSQGRNRVTAVHKANIMKMSDGMFLSACREVSKDFPGIQYDEDLLDRVCLQIVQNPKPYADRVMVMPNLYGDILSDMCAGLIGGLGLTPSGNIGRDASIFEAVHGSAPDIAGKGLANPTALLLSSLMMLRHMNLDEHAAKIEKAALTTIAEGKAITGDLGGKASTGEYTKAIIQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFW5</accession>
    <name>A0AA38JFW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (cytosine(38)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.204</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA (cytosine-5)-methyltransferase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1144254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.204" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3735251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="431" mass="48463" checksum="46BC3AD544502FAE" modified="2024-01-24" version="1">MSYVIISMHDRSSVVRALEFYSGIGGLHLALKRSKVPGIIVKAFDWDPNAAKVYDANYGPSLATKKDILELSAPLLASYCADFWILSPACQPYTVLNPNAQGILDPRAKSFLHLVRNVLPELVEMGAHPTHFLVENVGGFEGSTTRQIVISQLHSLGYTTAEFLLTPLQFGIPNSRLRYYLLAKTAPFIFPTCVQPAKTYRCIPQYNEHDYETLSSWIDPRMNLDTELNDVHATEIRHYLDDEDGSPSSPHLHAVSDRVLEKWGRLFDIVLPSTKRTCCFTRGYTQLVERAGSIIQMNTELDTGKTFDSFLAAQAAGQQDAVSILRPLLLRYFTPSELLRIFHFNPPLHPKKIQSSLLSTISSTAIGAKRDESNDDESSHSNFEFVWPEGISNKTKYRLIGNSVNVRVVTELINFLYEDWEPGLTIARKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGA2</accession>
    <name>A0AA38JGA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_999349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGA2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="280" mass="31305" checksum="B362953926570C8F" modified="2024-01-24" version="1" fragment="single">VLRVLSSKGYDEAKARKRLNREVYVWHRLNHPNIATFLGTSYHMENRPSLILPWFKNGSASEYLKLRNPDSDRLRLILDVAEGLNYLHTCKPAPIVHGDLKGNNILITDDGRAILSDFGLSQVIEDLVGPTGITPSVFAAGPIRWQSPELLMDVSETCRPQLADDVWSFGCTAYEAGLLTGSVPYHFRLRDSTVIHDIQAGVPPPGVEENNLNRGDGGIWDLMNDCWISSPVERIKMPQVVNRLREICFPFRSSSSFSTDPVPYSPSTPATTNVFMRPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGP1</accession>
    <name>A0AA38JGP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_997556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGP1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="233" mass="27170" checksum="AA4C4D9C09437ABC" modified="2024-01-24" version="1">MHTLQLRCWRLASSQIHSSSLSCIRSISSNSIPSFPFPIHPRPSPYEIFHLPYGCSQQEIKERYYDLVRLYHPDSPACRLIPHSKRHARFQAIRAAYDSLRKGEKLGLKNAHLFDEYADEIARRKNIFHKHQQYRNRGPNVAKGYEPRYEWNSNADHRWKDHMILGFGIVSIIIGVFPGLILFPRHIKQHNDAVQNLTRARLEATQHGEQRRLEIKSRLQDIKSSSDEGSSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGX0</accession>
    <name>A0AA38JGX0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_341187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="959"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1435" mass="157669" checksum="17BE00D6BC15DC54" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGZ8</accession>
    <name>A0AA38JGZ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_997239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGZ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="289" mass="32561" checksum="ADBCFEAAA79B556F" modified="2024-01-24" version="1">MAFSGWIISQCQSAETPLHVQLQNGIRVIDIRLANIEGRLIAYHGKYPEKTPFRTILSVIHAFLTSPVSCRETIVMSLKQEDYAVTPPPVFSRLVREEFAQSAGGLDILFLESRIPKLGEVRGKVVLLGRFGGDGAEWENGLEGLGIHPTTWPDSERDGFLWECKDVHVRTHDYLILPRYAIPSFLYMPEKVSLATNFLQPPSNNDVQPTLSIVYTSAVSFPFAAPKTIARGFGWPKWGFGVEGVNSRMGKWILWHRILFSKYDSLCSKRSMLLCFPACVSSYLLHLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH97</accession>
    <name>A0AA38JH97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_488370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="332" mass="36742" checksum="1DA3277E79FDFF72" modified="2024-01-24" version="1">MVQTVAIADPSSNGEVAVQFLSESKAFNALQFLGLIGSVLSLVTALFSSIPRQATWYNFFISWIVFCISYLLLFFAGHAYGGEPELYLCIAQSSLTYAASPFAASCCLALVIQLYLNIQATLNGKFIRGKRYMRIVLLITPYIIFISVMIESLAVNYGSTLTLTETLIIPNSKMSFATNVKFSSVSYCSLENHLPGRITAALVIILIVPMLVLNLLIYLSFRKHRSFLQEGNYTSMFVRVSAFTLCGLISVIVGLFFFLRAFIGGGDSNQGLVELDIILAMAPVSAVVIFGTHKDLLNVWLFWRNQTPIAKKVENPVPPLSNVHIEYEVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHK1</accession>
    <name>A0AA38JHK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chlorocatechol-degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1027751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHK1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="266" mass="29294" checksum="17E61A542B14A68F" modified="2024-01-24" version="1">MSLCEDCIKGIRHEGSPEGHWETIDGVDSYVGTPTGDYQKDKVLLFLCDVFGPQLPNAQLLVDDFARNGIKTVAPDLFEKDGIPFDVLESEEKRRAFDRSSWFSRHTPAISRPPLDKVIAALKTQGVTTFAATGYCYGGRLVFDLAFKNIISASIASHPSLLKVPDDFEKYLSVSSAPLLLNACTIDKQFPEPAQLQADAILGGDKFVPGYKREYFDGCRHGFAVRGDLSDPTMKAGKEGAFKAAVAWLYRYGFGPEGEKARKVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHV3</accession>
    <name>A0AA38JHV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1079296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="92" mass="10886" checksum="8D65973D5A372C21" modified="2024-01-24" version="1">MLAIQFLFVIATIIDVVILGYCPFESLRSRLVEILLRPAGCSRRWVSKSSWLSFIPTSQLIHFVKLEIVPRRKHFVCRAWDRTMSFYVTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI33</accession>
    <name>A0AA38JI33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1078133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI33"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="80" mass="9950" checksum="CBCB216BB1D2F037" modified="2024-01-24" version="1" fragment="single">FLLYILFLMFYNFIFILLRLRFRMELHLIFGCFSFRFQSEVFWFFNFKPSFLLFTLHPSHLSFLCCTLAVLFWELHTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI64</accession>
    <name>A0AA38JI64_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1058330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI64"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="755" mass="83911" checksum="243128B456CD714C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI75</accession>
    <name>A0AA38JI75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1098633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052293">
        <property type="entry name" value="SRRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239:SF41">
        <property type="entry name" value="MEMBRANE ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239">
        <property type="entry name" value="PROTEIN CBG20215-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1409"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1436" mass="156427" checksum="EFA2CA6F15787B5B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI90</accession>
    <name>A0AA38JI90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1211386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI90"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="416" mass="47775" checksum="ED549427C7BCA926" modified="2024-01-24" version="1">MFLSRSPLNRVARINGFSAQIRTVSDKPSTRTSRARRVTLEDFAREPKKKKKIGSRFETHPDSPEDKTHLPPRDKWRQIFAWVPVNDRVSLSNPETANTVAECFVPKGNTDRVIIEAFPGPGQLTRSLLALPKERIKKLIVLEQEPKYLDYLRPLAALDSRLKIIPFTALEWDTFDRVEEQGLLDDVETFPWDGGVHPNLQFISHLPITVYGEQLIAQILRLIPNRNWLFKFGRVKMNFLLSDYIWQRLTASPENALMRCKLSVMATATADFQTKMYDELQPYAEHFHPILVKKATDKLSNRRIGVPFQAVEITPLEKQVINPDKLDTWDYCIRRLYVRKATPLQQCIEDLGPGAQSLIPKLSATIDPKTIIRDITVDQWASLIQEFDAWPFAPTDLGINDAKLDNYGGRGILNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIC9</accession>
    <name>A0AA38JIC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_996583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIC9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="73958" checksum="0FE60DFF7BC4A011" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIR3</accession>
    <name>A0AA38JIR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_998068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIR3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="104" mass="12085" checksum="BD159C54ABCD2A5C" modified="2024-01-24" version="1" fragment="single">MQHCSFQNHVLIQHSEHTIANLRAELQHVNHHLAKVEKACNTAEVNLSLQNAQHRREVSQLNQEVETLKSRPDLEGVVAELEERINEMEDLLKKKCEEIEENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ94</accession>
    <name>A0AA38JJ94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1038321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ94"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="520" mass="57452" checksum="4A024998FCBE7333" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJT0</accession>
    <name>A0AA38JJT0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Argonaute-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_298221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJT0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="231"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="520"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="874" mass="97380" checksum="9A00BECE19F5A9DA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLB8</accession>
    <name>A0AA38JLB8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetraspanin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1132010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLB8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="352" mass="40405" checksum="4099498A1CA4D2BA" modified="2024-01-24" version="1">MAPLLPLTYPLYDLLRISGASVESDHKKLIPSIQTTEKFTNKWPRPQPLRAPNLNSSTKNRRNRKLLIQEAVSELEEGYSLGLDKIDRWTRFKWCLMISVVTVLCYGSGAMICAILTWFRTWNHADVMYVADNDILILITLAASILMFTAILGVTGTLLNSRPILATYTLLLWPALISMLAVGYISYKRYAFSLDRKLNFSWSQYYTPLGRLMIQSSLRCCGYYDPLHEATTTNKCYPRTPLPGCKGKLYRFERENLSLIWSTAFSLVSLHLINIFVALLCSNHVTKVFGKRITPKQYRLSEQDLKTDAEKIKSYIVEQVRPIYSRASSSTVFREDREERMSLLMKDPARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLF9</accession>
    <name>A0AA38JLF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_998395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLF9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="808" mass="92255" checksum="FC2066CDD523C757" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLX1</accession>
    <name>A0AA38JLX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1075606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLX1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041234056" evidence="2">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="180" mass="18466" checksum="A85394071A1E71D7" modified="2024-01-24" version="1">MRAFIFTFLTFLLVFVCAQTETVPDLDGNTVVEVITTNRLGVITTSIISTIAVDAETTSTTGTTSTTATKATTTQPQGGGVVGVPGTTNTVDPNGPTPYTYTTVVDGITTALEATFIPTFTTAPGTPAPATGTILDYSQWLSEFGSSTTATNSAPRVSSSSHLGTAILMAMGLGWAVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM16</accession>
    <name>A0AA38JM16_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1131632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM16"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="24"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="421" mass="46855" checksum="45E1F2CFEC14485A" modified="2024-01-24" version="1">MHLLDVDYARSQFPALKTGFIYGGSQVAVNVADRIYEYLLHHNVQFGADYSVSVESTRRVMEDAPEAAMKLFNAQSRDEIVFGASSTINLENLARGMDGAIQTGDEFIITREHEANAGPWKRLALRRGAVVKYWTPTPINPNNPYSVVYKVEELLPLITAKTRILAFTACSNILGTILPIKDIVQAVRTAAKEKGTKKLEISVDCVAYAPHRRIDVRDWDIDFCVFSFYKVYGPHISALYVRLSSLHDSVAAITHHFLKVDKKSYKLQPGGPGYELVYGTTGVLPYLLSLTPENDLQASFDAIAAHEQKLVQPLLAFLTAPKQIERGVRIVGAENAGVTRVPTISFIVVGERATKSSDIVKVFDKKGGIGIRFGHFYAYSLIDELEPKIDVDDGVVRISLVHYNTVEEVERIIEILKEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM85</accession>
    <name>A0AA38JM85_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1151954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM85"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="376" mass="41493" checksum="49ADCD0C6F4E494C" modified="2024-01-24" version="1">MSDVPKAVLYYNSASIWSFVVLLTLEEKGYGKDELDLKAVDLGTQPLDSTKIAEVLSHSTAKGENFGPKFLRINSKATVPTLVVPLDKSLSVEIESRYKAITESKAIVEFLDKSRSPLSHTHTTSDAPAPILTPATIDFTATCKVIIEDLLHSDDADPNKLLYMNARDEESLRALADSLIPLMKGKVDALNHCLSDAQAGNVRASEKVVKFWTSKKEAAQMLLEVYEKAKVPEAELDANAKAHRAEFFKVAKAAWEVGLVHVLTKLNELIIAPYALGEQYSIADPHLTAWLATLILLAGGDANDNGNVAIEKLGKHIGSNLVLSKVVASEAPRTDAERTSARTKLGLYWDTVRERPSWKKVYGNRVNLDLYQKRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMC4</accession>
    <name>A0AA38JMC4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1059576</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMC4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="120"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="439"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3734922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="502" mass="57708" checksum="AF642F6C6A62DF24" modified="2024-01-24" version="1">MYQPSPGSSSPITSAPSPLQIPENTTHRTRPDDYVYFERSTAGFSSEAVARATAAKLKLVSYYKMAVDSAIERNARRIELETKLSQTLQPESKERELRKHSKMESQHLRLRRTKIKLTDFKTVKVIGKGAFGEVRLVQKVDTGKVYAMKTLQKSEMLKRDQLAHVRAERDVLAESTSPWVVQLFYSFQDPLYLYLIMEFLPGGDLMTMLMKYDVFSEDVTRFYMAECILAIEAVHNLGYIHRDIKPDNVLIDRFGHLKLSDFGLSTGLHKVSDGEIYKRFLEEEKTRNPARNSVQVNPINLTMSRDQIATWKANRRKLAYSTVGTPDYIAPEVFLMKGYGKECDWWSLGAIFFECLVGYAPFCSDNPGDTYKKIIDWPKYLFFPEEVFISPEGEDLIRRCVILPLHFGRRLDVLSPFSMMTWADSRLTANQIKSHTFFYGADWSSLRLIEPPFVPRLQSSTDTAYFPTDDFGNMPDQLEQVEGISAEKDLAFINFTFKRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JML0</accession>
    <name>A0AA38JML0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1069808</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JML0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="243"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3733205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="681" mass="75921" checksum="D2A4EBE86225EA99" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNQ6</accession>
    <name>A0AA38JNQ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_820378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNQ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3735657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="336" mass="37526" checksum="1BF6445232D63C09" modified="2024-01-24" version="1">MPNVDSSSSSADDSSPQPQTPSLPSSLTGPSIVDPANADPSPDNITGGKKRKQNRRINTAERRATHNAVERQRRETLNGRFLDLAAVLPNLSQIRRPSKSAIVNSSIAYFHASRRHRLLASRELRLLKFETDALRRELNDWRDRASIRRVQEPTRSDEFSLVLSGELEILPIDGIDNEDGEDGDDDLYTPIVSPEDNSDHPFDAPSSARPPSSSHPHDSYNMSAPYLMQRQMGNRGPVPIIASPNGMAMENPVTGFNPIGGLAEPYPSFNEMDQGMQNKWTMQEQAYYERERVHNGRKVNFGEQPSQFLEQHWNAGNDMQNVDIGGNMDSAQFGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPH4</accession>
    <name>A0AA38JPH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_244090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPH4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="40795" checksum="6A1564911D521461" modified="2024-01-24" version="1">MDHSHIRAGFFSISKYCTFVNSHIYLLTTISPLAGLRQNPFSAQKYNTPAMQLLLRPVLFMGLLFLVKTFATPVCTRAGTGSGQVFSASDSNSGFCNVRKLPASNSLSIHSRALDGRKEVIETRLTLYTPSWPDESDISEELAVKIYNATQIILPSLVPVHPDARRPNIPENSENLAFNVKELLYFGTSKDEEFSLSVDLRHNGQRILTEIDFEQRTFESQSLRAGDLFGYADCYHNYSREPCFRFRNGFYQDSRMEIMKRFPELEITKVRAVKARKGKDLVFTFEVQALFYTLHHIITLFLQEPRSGSEKWQIHEVLVEENREQNGRTWRSGAIRIIMVSLPRSMQRDTFASAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPT7</accession>
    <name>A0AA38JPT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1151943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPT7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="167"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3734803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="77604" checksum="E22DFA2E8AE8C9B4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR20</accession>
    <name>A0AA38JR20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1149599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="128" mass="14036" checksum="528BB4920BF4D2D6" modified="2024-01-24" version="1">MPALLHNYEVLLDFNNDTSRPVSIQLSQDYGRNTNAIVLLLPSEAVSLILQPGSLYRYAVKINSGSVYKVADVSARSWRDIHCDISHLFSGGSTSRLSTSSASLDGVVVDLRSVHFPYLQASMFDVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRF9</accession>
    <name>A0AA38JRF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1061262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRF9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="163" mass="17371" checksum="1457D6A9AA800308" modified="2024-01-24" version="1">MDKSLINVQNRFMPSDSSGLQHEPPSINSLNRAERARRRGVASALSPVPPVPTLPSFSSGFETISEIIELSVDPSPLTSEHDSLPVSRLPSPASSITRRREWSPVGSRRSSGAANRRSVSPTSHSPCSSTNGDNDRVSEGGDSVSHRTDAPVHPVRARSAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRJ3</accession>
    <name>A0AA38JRJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1136899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRJ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="448" mass="50304" checksum="79BACD858A628836" modified="2024-01-24" version="1">MQLSFVSAVVSKSYYGTSAWRWCSSPKNVNTGIRFRLREDSDTASSLIETRTTNLRLHIAVPSIALFSSLSYSALRARFAGQIYHLLAPYKFLLKFFSPWASYPQRSTDMHLLSPAHLFSMVLLSIVLGVMTMAVPLTVHNTDIGKWQWHSKRDVNREFTVGLIRRSGQEQQLSANPWTLLPTIIRSDSAFHTEEYWHLYITRRHSFHAVQMGQVWQFKQVDHVKPVYPKLSLGSITLPSDARSIKANAQRLNFAALNALINFLLEENLPEGLKYTPCPKDPDAWTKIFLAMTDYDRYLETYPNLNDKPRYVKLLDKPDGTTVAPQAASNSEGMSQLSTTSGGQSAGGREAQVTQGKSVKEQMGGMSSSTDPMRISNLLGPQKNGKQTQGMKISNLLGSANDVTIERKPYADAISTQLLVVGLTMYHWIWEKKVTEYAVGAIDKTTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRM3</accession>
    <name>A0AA38JRM3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF4e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_997983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRM3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="284" mass="31788" checksum="6F51A6F2C7E3C856" modified="2024-01-24" version="1">MANSYFSNYSQSRFLANSSQMSGGIQLPISTQIAPKSRVPSSKHFSTSLSSGSDRSSTKEKTSNGSSPDGSEPHPLRNTWVFWFRQQRTPGNKLISYEEGIKKISAFASVESFWSLWTHLAPPSALQPTTDYLLFHDGVRRPVWEDPVNISGGKWIIRLKKGVADRIWEDLVLAVLGDQFNECRQVEENGGGEEVAANWEDGSDSGAELPEICGCTISVRQSEDIISLWNRLDGDVKVREKIRDTIRRVLHLPTSTIMEYKSNNDSMQDKSSFRNSAIDRTPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSA4</accession>
    <name>A0AA38JSA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1148881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSA4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="482" mass="54084" checksum="2A40D2A69514C359" modified="2024-01-24" version="1">MSTATGTQPCVRLASPFSSKSLQPASIFSLAISNPRSWLARFARTSILSVLSDAISVGQLTLTDSEGSHTYGRYRKGATLSALPSSMMHSAQGIWAVRTIHLHMRSSLMCIRIPVSEAYMVGDIEVEDLKSCMDLWLNNQSGMEETLSSSFARFSSAASGLYNSFFGQTKNQARLNAIASYDQSNTLFKAFLSHEMMYSCALWDDAEGGVRGDLEMGPTPGDLEAAQRRKIHHVLRKARVKPGHRILEFGSGWGGLAIEAARTFGCEVDTLTLSIEQKTLAEERVRAAGLEARIRVHLMDYREIPPEFEHAFDAFVSIEMLEHVGAKHYQTYFKLVDFALKSHEATAVVSASTFPESRYTGYQSEDFMRRYMWPNSCLPSATALITAAQTVSRGRFTLEGVENHAAHYPRTLREWGRRLEKNLTQEMIAQDYPALRERANYDAFRKKWQYLFVYAGAGFAKGYITCHMLTFIRQNDCPELCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSI5</accession>
    <name>A0AA38JSI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_991653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSI5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="205" mass="24354" checksum="784C012128A218F4" modified="2024-01-24" version="1">MEKRVARSKQLHKCEIGRCLIIDPRTGNLRCKRRAPFQISNDDYINEDGEWGLKRSYKFMNGFVRPITVNVRCNNDGKLLTNGNETRNVSFYISKYQLKVQGRNFNTSAVFAKTLAYHRDHSDYVETLQERQRLFLFRVCHAMNREQELAAPMVMSYLMGWGDMYRSHHYIPIYWTSFVGRLLEAFPSLKRYVILFVRRVFANIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU30</accession>
    <name>A0AA38JU30_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_611941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU30"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="819" mass="89613" checksum="A2AA9B004432BD6C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUD1</accession>
    <name>A0AA38JUD1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_996301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUD1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="93" mass="10599" checksum="9729656C2FF0E9F9" modified="2024-01-24" version="1" fragment="single">IIDGRFYTECRHFHAMATHKQDCLRDNCVFSVRHTHSFSLSPTDCKSPNCIRMMAQPVQNPIRFSSMNCANCRARDGAYVMSDLVGLVLILFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUV8</accession>
    <name>A0AA38JUV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1192619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUV8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="138" mass="15358" checksum="E59F00E067C92606" modified="2024-01-24" version="1">MFGQLTYSVVTELPAVYLLYDSPFWSGAFLIFENRLASISYFDRFERELEALRKEFAESAQTRSGRSSPTNSDSTSTLSALPTSEDNLPSFSPNFSDSSHSPPTLDSHPLPNIESGSEPNFDGLQMKPKKDQCPFCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVW8</accession>
    <name>A0AA38JVW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1135677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1397" mass="149989" checksum="F4A15FC88DFE7D02" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVY3</accession>
    <name>A0AA38JVY3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_167212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVY3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="459" mass="51798" checksum="822DB3138CFED91B" modified="2024-01-24" version="1">MGLDRRGLYDIYKYRCWYTFVVVVVWYHIVYLVHLLLLPLPPPLNTPLNPPPPPPINPPLLFTNLKNQQNLLHLTKELSLHDIPLLFVLAPLGVVLGLIGSVPFGWVLWNLGAVHPVLGFGIGVVWVWSWGVLRGLLTVISAWVVGRWYNNNNNTKLLLPCLHASLPTITLSSLILSAIHILTFLINLLSLFSSFSSWFSLWSWFWFWFSPWSRFRSWTHLLVWCLHRITARFNPYTLVYIGFTGAHPNHSLSIPNRPINKVSSPLPLPLAFILAFALITYSSPYPSPQPTLSSFPLLLNLTLTSTLVSAFCTSLVNDIGDALWVSWLLDGEGHPGREEKRKRVREVFDYSSPDSRHSPNSRHSLPSPNSLDSPNSPNYANSEDPESISIPISVIVHGRQTQTPTQTPTQTQTRGSSRNINTMDMDPMDFTDTMMDDTDTDVTDTDMDETDLDPFVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWG0</accession>
    <name>A0AA38JWG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1149377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="433"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="12">
        <location>
            <begin position="1403"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1898"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3736911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2065" mass="236356" checksum="8AA9FDD3BBF70C49" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWQ3</accession>
    <name>A0AA38JWQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1064459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="476" mass="53282" checksum="126C7C7433A87F06" modified="2024-01-24" version="1">MYSKKTPQAPPIPRGGACNNCKRRKMRCDGQRPICGPCSRSSSLVDCQYGRTHADRLQEQISVLETRLEQLQNGPNDSNTRPNPLALHDPYASRNFPVLSHNTPTENELIEAFLPYTSQLGFFLNAKTLLDAFSNPMSDPTQRPTHALSASMVLLGAYFSRYLIQNSSITLELIETYLLKAVQATSLGLSESHPQRILHTLQANIVIAHYFFLHNRVIKGKWHLDHAVSLVLSARLHQIRSSSVQIQFPNIYVQNVSEEGEQINAMWTVLALNCLWSAAEGIPASIAYTTEQRRIDTPWPLDSGSYSETTLPPSLKASHTIQKFLSGIPDEGNSILALYAKATILFEQTTVFWKRYTDGTQPPSSAARTFTNATESRDFQSSYQTLSSLLTHLLNNIPPVDGNQFRPYLEQDTKLRLLTIHVVVRVTIIRLQCTFSAYFPFRGPVLLEMANGIMECLTKADLDSIFLDPIMAVGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWU9</accession>
    <name>A0AA38JWU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase subunit VB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1037977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWU9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="157" mass="16815" checksum="4877CB77A3DC57E2" modified="2024-01-24" version="1">MFSRAISAARPAANRALRSNFGPSTLRAFSVTPRASSGGHGPPPPGLFGPGAKPGEVPGIADQSTGIERLQYLGDAEGIEVFDTAPLDSSRIGTKKDPILVPSPASERLVGCTGSPADSHDVLWFPLMKGRQHRCLECGSVYQMDYYGEEHHDQHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWZ8</accession>
    <name>A0AA38JWZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLS1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1049327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWZ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 C-terminal" evidence="2">
        <location>
            <begin position="429"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="720" mass="80231" checksum="31F722DE33554803" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQG1</accession>
    <name>A0AA38MQG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1009088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000126">
        <property type="protein sequence ID" value="KAJ3711083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQG1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3711083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="186" mass="21146" checksum="C60C45EB707C1034" modified="2024-01-24" version="1">MDNWKIAILGDGGVGKTALAVQTNLFCYFATYDPTIEDAYRKQWVVDNRMCLTEIIDTAGQEDFQTLRDQWVREGQGFIFVYSITSRSTFERLETFWQSVQRVKRGNPIFMLVGNKSDMTWEREVSQNEGNNCARQFGCGFIETSAKTAKNVEDVFASVVCALRRSRNGKVGSPREKKSPGRCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQR4</accession>
    <name>A0AA38MQR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1104261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQR4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041317706" evidence="2">
        <location>
            <begin position="21"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3714333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="563" mass="63663" checksum="F62126C4812E0EFA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQW8</accession>
    <name>A0AA38MQW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1160530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQW8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="170" mass="18369" checksum="B19E34D4296DE8C7" modified="2024-01-24" version="1">MNTSQLSSQFHRTSRRSLKGWTILFIAALSSTLLVITGYASPLPCSEHEHGSDITASGTSHRPPAHDLGIASRYLQLDSRGGAVGLKKVLSRIALAINPDWVLLGFAYVEPEQGQRIGDGNSVSLATLELPGMTLKSTLSAIYLLPQLGLPAQNPDENLEIQILTTFDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRY5</accession>
    <name>A0AA38MRY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1042239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRY5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="106" mass="12264" checksum="A683EAF3E805E537" modified="2024-01-24" version="1">MRSNKNKCWISRRIAGSGHENKINIERDDADEDDNDNEDDEDEDNEDQNPTESSFQARLFRTPLKGRRRDRKGKGKTKLCMDEDFIAHTQVPCLFDPLCVGHTRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSW6</accession>
    <name>A0AA38MSW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1132740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSW6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="26"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="39868" checksum="73E11E9957A6998D" modified="2024-01-24" version="1">MSITSYFFPISKDTGKRTSASGSRIAEETIEAIEKGSFDLNGATYDLQVAVNQLRQSTEYWSPDAKKLVERSETKIVSSSSRNVEISLLEISSLEGATFLDAQISRQSDSASATTTSPYFSSPKIGLLNFASATKPGGGFLNGASAQEESIARSSTLYYSLTTRNGDEFYKLHKRLKNQGKWKGFGKGKSKRQEEDTKEENHTRESGFYTHAMIYSPSVSIFRDDTGSWLKPLSVDILTSAAVNAGDVRTKRRIKDVNQTERDALETRIENEMKERMARILYLFALKGVRNVVLGSFGTGVFKNKVEVVARLWKELLIGVHAPFEKSFDRVIFAVLGRATYETFEQVLQLDGYTDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTX4</accession>
    <name>A0AA38MTX4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_114987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000123">
        <property type="protein sequence ID" value="KAJ3711130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTX4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="509" mass="55625" checksum="CFB6AAA2B78D4174" modified="2024-01-24" version="1">MSTFLSIPNNLDMLALSSASSSSISSSLSLFESKHSSDSQTDISPPASPLDEDAEKDRTHRRRLTGFFLDEYDEHWDLETPTSNLGDLFSPVLQKDQESLAADEAGYEAESSDGDEARVFVLSGERKKRSVKPKPKLRHYAEPNIESMEERSELWTLPPKTTERLSVVAQDRKATSPPIKPVLRPQLQNLNSPSPIIALPSPKSLNQFPNLPWDLPSSSSINLQSSSQAAPIIDRARRNTALQKPLGLGLRIPGMLEPQSGQSGHSIKMTASSSSDRVVEEKGVTLIGLGIQLPSDLPSASLSNPSPSIESVSVKRRSFSGLGYGLPPTRGRGQSTRLGPSQSTVRLVTPTEHVRDSEPPSQTLEQVSEHTAPGLCTVSIEVRQRRAAIALKPCLSSSHFAKRRLYPILETNSITTTTTSPTTSSNFPSTSNRVSHSQIKKLPSFSQPENQISFAKRTKSASSSPSSLCSSRCSTRLPLQQKRCAFSFETDQYFSTTKGDSNMFTKTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUQ2</accession>
    <name>A0AA38MUQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1067328</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUQ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3733484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="328" mass="35552" checksum="71FD68E3E1C79772" modified="2024-01-24" version="1">MDISSILQGGYHHPLARTWQGRRQLTKSMLMYPIFITDDPDASVEIASLPGQRRWGINKLEGFLAPLVKKGLQSVILFGVPLKCEKDMRGTPADDQSGPVILAIKKIRELFPTVYIACDVCLCEYTDHGHCGLLNADGSIDNSPSVDRIAQVAVNYAKAGAHCVAPSDMMDGRIKGIKKGLIDAKLGNKCTLMSYSAKFASCMYGPFRDAAGSAPSFGDRKCYQLPPAAKGLARRAIQRDTAEGADIIMVKPALPYLDVISDAAELAPDHPLACYQVSGEFAMIHAGAAAGVYDLRTMAFEAVDSMIRAGATLILTYFTPDFLEWLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUR7</accession>
    <name>A0AA38MUR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_206627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUR7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="188" mass="20710" checksum="CB98EF73D93A72AC" modified="2024-01-24" version="1">MLCRLSLELRPKLGSGQNCVQLQDLCFSPSSPYSDIDSTDIASYTIARTLGVVDIVKASTSDKQTVHARREPPSIHIREPSLDQYDAHNHFFTLGSDSSQSIAGTDSSTTPSDVRLTAYFTSGDHNLELSGVGVFSPATSRPPSPTTSRRKLEPDTHSTPSFHEFEVDDGSVHFRRRNKPTATREYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVN6</accession>
    <name>A0AA38MVN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DFJ43DRAFT_992713</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVN6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3734714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="405" mass="44476" checksum="A77765E7033D5C0B" modified="2024-01-24" version="1">MFTLIPYTLKLLITTLLWDNSPPPESPSPELQFHLRHMHGVSNNSRTIFADIPQSYSDFAKSYTVKTHNILTYRPPSFSAFSDARSKSINNGQSGLLAWDGIDMQAPNSSHRETLLTLAKMTSNAYNEPDDKEWYGLGPDWNSTFSYGWEPDSDGFRGHVFVSTDNSTVVVSIKGTSVPILAGGPTMKKDKLNDNLLFSCCCARVGPTWSTVCGCYQGGNKCDLPCVENALIEKSLFYSVGINLYNNITYMYPEANIWVIGHSLGGSLASLVGITFGAPVVAFEAPGEMMAARRLHLPLPPTTHHITHVFNTADPIPMGVCNGVISTCANAGFAMESRCHFGKLMRYDTVGKLGWRVGVQNHPISTVIENLLMEDWEKPGEKIGALGRETPELVDEDNDCPVSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVW9</accession>
    <name>A0AA38MVW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine-S-conjugate beta-lyase</fullName>
            <ecNumber evidence="2">4.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1207142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVW9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3718653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="680" mass="75586" checksum="1B348C45CF03E559" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWZ3</accession>
    <name>A0AA38MWZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1098538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWZ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="273" mass="28548" checksum="BD944CA9BEB190B9" modified="2024-01-24" version="1">MPNGSRSSDVLTSRSADIHQPPPTHDHARDALRLALGSILAPKRSTPNPATIRSGSSSGTASPAHFQFPYHTGSHTPSPANSSSTPAPQGPPSHLSFPHPHAHQHHHHPHGHSHLIPLGREHSHSVSGHSSSSHSPHSSSPATPITESASSPFNHYPRPGLLTRSISSSSAHNLSSNRPSPVIGGAGADSPVPPPSLPAIQDEHEVEHGIHAPAPRLPDNTDASTETAALHPYIPTVAVSSPGESPIVKNKLIQTLEGKTHSAWDALIHGPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX70</accession>
    <name>A0AA38MX70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1129805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX70"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3736214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="252" mass="28130" checksum="423742D35B35E8E3" modified="2024-01-24" version="1">MRFASRLLSSARVVARTTRGSTGLSSPLVCRTPVAICTPRIAGYATETPAESVKKQEFQVASEIPPPSGIAAQINDEKTDWSKSYHGLSEQAFPKEVADVLMAPVEPLDIEMKPDGMIYLPEIKYRRILNKAFGPGGWGLAPRTETNVGPKVVSREYALVCQGRLVAIARGEQEYFDPSGVPTATESCKSNALMRCCKDLGIASELWDPRFIREFKSKYCVEVFAEHLPTKKKKKLWRRKDQPKLSYPYQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX97</accession>
    <name>A0AA38MX97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1092922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3722726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="499" mass="54752" checksum="CD5D670F6E7DB1B3" modified="2024-01-24" version="1">MAITLILSISNVNGKYLVELEDSLSEMAFILLVALLASIISLHVRSSNAIPLESARFTQTSANLPGVDIRFVNNSGICETTPGVQQMSGYINVGQNMNMWFWFFEARNSPETAPFTLWLNGGPGCSSMIGLFQENGPCHVNADLTTSFNPYSWNNLSNMIYIDQPIGTGFSYGTDTVNSTESAAPFVWTAFQMLFETAQFTKFESREFIFATESYGGHYGPSFVTYFDQQNTLIQSGAIQGEEIIVSALMINNGWYDPLLQNKAYVDFATDAPGYGQLQSDEVIAKLNEAFYGTNGCQVQEQACYDAGNSSASNKICSTADNYCIDNVFVPAVGNRDSDDLRQNSSALFPPEYYVDYLQQASIQSAIGAEVKYSECPDAPYELFTKTGDDARTWLPQLGALANSKLKLLIWAGDADINCNWLGGHASVLAMDWYGSAELATTPFTNMTINDTSVAAVQNVDNFSFARVYASGHEVPAFQPVAALEIFKQVLNMEQLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXE2</accession>
    <name>A0AA38MXE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_595172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXE2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="23455" checksum="8CA6A83D48D61561" modified="2024-01-24" version="1">MMFRSLPIHLVLFLLELTSLPRGIHSSNIISRTIHTTHQIASRHTKVIARDLRLAFGAVLVSEATQQSLNNSRTVYCKSSAAPGSSGLGSSGGQGNSSSGSSGSSSQGASTSTKSAAAGSSTASAVSTPWKLVEAHNGSDFFQGWSFFTGSDPTHGVVDYLDENDASSAGLAYVNSAGNAVMAVDTTNNLTGNRKSVRITTNSQYSQGIWILDALHMPTGCGTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXW9</accession>
    <name>A0AA38MXW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_538690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXW9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="238" mass="26862" checksum="2748B56392F6D8CA" modified="2024-01-24" version="1">MNNGLPLGANTCDFGHTDSPYDLHYIAENPYQNLEMISNRSPPSQQLTPVEYQHLNHEMYLPSASSQLNPYDFAQSSINHPGALSDSGYLFPQPNFSPSPEYGDVNHNAQSWEAQSFIGYGGIIGHTSSNMMHDINRGYSRLQDRRPGDSFYQPDARLTVGPELTIGPPQREQPKKQTLACLFCRERKIACGRLAPGSLDMTCNQCARRDLLCTYPTESRRGQHKRKSQRGREPRLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY91</accession>
    <name>A0AA38MY91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1002035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY91"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="465"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="707"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3726531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="737" mass="79776" checksum="80E4561CA674F7E3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N082</accession>
    <name>A0AA38N082_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1077068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N082"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="7">
        <location>
            <begin position="803"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3731717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="889" mass="96397" checksum="E8143E9F0AC52E00" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0X3</accession>
    <name>A0AA38N0X3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_341357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0X3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="272"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="711"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="855"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="923"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="985"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1180"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="855"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="943"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1186"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1201" mass="130205" checksum="8CB2FB6F66F09E3A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N136</accession>
    <name>A0AA38N136_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">DFJ43DRAFT_1075908</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="33">ET3784</strain>
        </source>
    </reference>
    <reference evidence="33" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="33">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="25">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N136"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="32">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="KAJ3732168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="905" mass="97226" checksum="98693A9EC1E22909" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1R8</accession>
    <name>A0AA38N1R8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1130883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1R8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="165"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="770" mass="88065" checksum="C35BA661466532A6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2Q5</accession>
    <name>A0AA38N2Q5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1066198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2Q5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041251062" evidence="2">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="171" mass="17576" checksum="7E509BCF48EDD826" modified="2024-01-24" version="1">MLAFSCVSLLILLASQATAFTFNVSFGTQNLNATDILPTSLTGLIAPCASTSATCDNVQSELSACQNDAACLCANQLVADLRNCEQCMYETLINASAPLPDPKAGSTPILAGYQAACAAFNITLATTQVALTLPSNWDGPFGLGLNTVGTVFTVGAAFILGMSSLLLLSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2X8</accession>
    <name>A0AA38N2X8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1152060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2X8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000138">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="134"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="371"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="496" mass="54534" checksum="34EC6B5915470687" modified="2024-01-24" version="1">MTWGSFSRVWYIVRPLTRNVRTQPNYNGPVGHDPASKVPSYKLATPRQLVEYLNHYIVGQEHAKKVLSVAVYNHYSRFFANEAMLQQQQPQAEFEQTPSDSNSGVQPAKLRPLRYHPLPSSSSSVLPPAYSMFEKSNVLVIGPTGSGKTLLAKTLARVLDVPFAVSDATSFTQAGYVGEDVEMAIQRLLQDAQWDPYRASTGIVYIDEIDKIARKSGSGIESSRDVSGEGVQQALLRMLEGTVVSVQAKGSQSDSPSISSREGHSRSGHRAPSIAVAPKPDVYHIDTSNVLFIVSGAFVGLDNIIRQRLSKGHSIGFSSKSSPSTGGPLFFTPNQTSDYVLESVDPADLVKYGFIPEFISRLPSITTLAPLTIPDLLQILTSVKGSLLSQYKALFQHSNVEIRFTSAAQDEICRKAYERGGGARGLRGIMETLLLESMYEVPGSDVKGVLITEQVVRGEAPAQYWRENRGSLVQFWEAWAAEETAYEKRQSSVQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N339</accession>
    <name>A0AA38N339_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1037743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N339"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041274834" evidence="4">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="112"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="269" mass="27986" checksum="3637D4DB5A4F5C5F" modified="2024-01-24" version="1">MMFTAAFLVQALLASAAFAIPTSKERAASRRARRSGATRQSKPLNRITSPTSEISNASYVEFSSNWAGAVLVASTATYKSVTGTFTVPTPKTTGGSGEECATAWVGIDGDTCETAILQTGVDFCVTGTSVSYDGWYEFYPAASFDFSGISFSAGDSVTVTATVISTTEGTLTIENNTKGTTVSKTVSSSAKLCETNAEWIVEDFEECEGSSCELVPFANFGTIEFTGASATTSSGTVTPAGSTLIEIEQSNKVLTTVSQSGSTVTVVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3M1</accession>
    <name>A0AA38N3M1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_710867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3M1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="677" mass="74587" checksum="FA6EBC943D868BC7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3Z3</accession>
    <name>A0AA38N3Z3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Heat-shock protein 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_991553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3Z3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="674"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="700" mass="79546" checksum="56C71636D54C33CF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N506</accession>
    <name>A0AA38N506_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1045675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N506"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="222" mass="24753" checksum="5510E18617EC5503" modified="2024-01-24" version="1">MEMLGRLSSFMTTTIFSDEVDCVLSIQCKESLPLSSAKQSPICTYVSQTEVGIVPTLISFFQLHNLHDQPSESASSTLSKLGIQPENDTTYTDVRLYRALGHTYLKDSGHLTTNPSFIVSVALSPLPTPEAEADFNAWYEEEHINLLSQVPGWQACRRFSLVDAIKSTVDSASPPRYLALHAYQDLDGFATPQFRTATNTPWRTRVMQGIVASERNVYRLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N508</accession>
    <name>A0AA38N508_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_987402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N508"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28969" checksum="09D0AEDBC8B14D80" modified="2024-01-24" version="1">MIESLLPETQEDQDKADDEARRKALKDLVQSWQDRLQLITLITTFLASVEASMLQVTMPDDPSNSSHWSQAANAGFMGSLVLHLYASFVSFFASFFLVRFKIQEAKREERQVEAADPSYQHGPTFKGSTILDMAAHNITRSPTSPRSPVSEGNGTFPREKENPPPSNRQIWSANPQLVQTGPFQRQPPINLLSRCHTMCLVTTALGFIMAMIGVVCYAWEGQSTSVAIVTSICICLCLLSCFCLVLPQQNPPSSHLFMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N525</accession>
    <name>A0AA38N525_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1052433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N525"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="341" mass="38454" checksum="5F25A0773F6AE44F" modified="2024-01-24" version="1">MQSSSKKKLNKDSVFYNEPWRILLQTYLRNALCPAPSSLGVHLRERPKEHPLSLLKFGDNCFSSVLKGIDVLELDIWDFRTMIRRYIDDAPDCFITETDKPVMKIPCYGVNSLDNGQINFLSRVDDQDAFLLLIMTFILGPVTHCCRILNNVPRQVPMAHSFEFIALRGPNSKPEVDWDILRIPATSFGQGSLSIICIPPWKVDLEDLRAFTMPSNIPRNSAHHPRFKDTSDAARIMGQLLWHVVYEACAPAGPCFVVTNYAFWCFGKFRAGEPKNNKGKGKEGEDEGWAAATVSPPIELEMSLPNSVRLPMRTEPMGLGCTVAECLTFWIQMTRGAASWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5Z2</accession>
    <name>A0AA38N5Z2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1148896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5Z2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="842" mass="92683" checksum="635F36DA95D366C0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2K2</accession>
    <name>A0AA38J2K2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1105015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2K2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="313" mass="34652" checksum="350B3B943D4DDFD0" modified="2024-01-24" version="1">MDNKKVAIFPASGKLGGSLTRHTLKLLPAHDVVLISRYPSKIPDDYRNAGATIRAADYDSPKTLEDVFSQVNVLFLISYPTFQHEHRTKAHKYAIDSAHKNGVKHIFYSSLAFAGLGDQSVAHVMQAHLDTERYLAQLASKDPSFSYTSVREGLYSESFPIYTAFFNLKNPTNEILLPHNGHAPGLAWVKIDELGEASALLLAKFYAAPDRFADKNRVLLLSGPREWSLNETVQALGRVVGREVLIRQVSVDEYAAQKHVGSGLTINGNNLAKEWATVYDAIRSGEASIVTPLLKDLLGREPEDFETTIRGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J346</accession>
    <name>A0AA38J346_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1165448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000102">
        <property type="protein sequence ID" value="KAJ3713010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J346"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="268" mass="30729" checksum="F5CA533202DE1D18" modified="2024-01-24" version="1">MSSTISSVPSLPIEIYEQILTSFWNQPLSTHDRAIFMKSSLAVSQNWAIIYMRIFSQDVYIPSGEFALKFLEILRDESPVYHFLNENGSLLNRRCRSITFQRDNDGVIVKKPIAPDSCRPTSVLVQGMLNTPTPEHPMGLAIYAVTRFLYSSNKLPELRRISILFANSTMSDLFTRNNFIGFPTQVTELDIHFTYDARTPRDVIRKIRRDATAIGLLPYSIKGVRTLRVRGLSNVAVRELVSSCAICEVVHTEWETYRFRSERQTRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3Z6</accession>
    <name>A0AA38J3Z6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diacetyl reductase [(S)-acetoin forming]</fullName>
            <ecNumber evidence="2">1.1.1.304</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_751390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-acetoin + NAD(+) = diacetyl + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15687"/>
            <dbReference type="ChEBI" id="CHEBI:16583"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.304"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.304" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3Z6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052588">
        <property type="term" value="F:diacetyl reductase ((S)-acetoin forming) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014007">
        <property type="entry name" value="23BDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02415">
        <property type="entry name" value="23BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR614007-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614007-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3719057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="310" mass="33501" checksum="8F12E179DA5623B0" modified="2024-01-24" version="1">MFTRFSTAVLSRVFSCPGRGFATSKAVSKSAIVTGAGQGIGKAIALRLAQDGFDICVNDLEINSGMVTNVVEDIKALGRKAVPAYGDVSKLPQVEAMVDTSVNQLGPLDVIVANAGIAHVQWAMDAKEADIQRLFEVNFSGVVYSDQAAARQFIKQRSGGKIINAASVVSFRPFPMIPIYSATKAAVRSFTQSLAMELADHKITVNAYAPGVVDSSMWETIDKGMGEINGLPKGENFQKTKSTITMGRTSVPEDVAKMVSFLASSDSDYVTGQTMLVDGGLLLVERWATQKNDYSIIHSHLYYYYTLKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4C5</accession>
    <name>A0AA38J4C5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1100914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4C5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3716296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="237" mass="26959" checksum="E264B5D6A25796AF" modified="2024-01-24" version="1">MERYFRNAKLTSRNDLQDNYKKVSSSNSTRLKPYTTQRHERGPKKKSLLDLLPESETPPSSSTVTKLLLNSLQEETNPITHSDLYERTEHVVSMASGHQVSESRRNHRIYHEARSHKLTAQKETTTATEHPQILSNVKVYIDGLLTGITDIEMKRIITRAGGQILYSASGASHILTSQPLSGSKTHRLLTKKTRIPVHVVKPEWVFDSIKAGKRRPERDYTIINSSGMMDMMMTSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4L6</accession>
    <name>A0AA38J4L6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1094854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4L6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3721373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="169" mass="18974" checksum="D1E9B260B0219FCC" modified="2024-01-24" version="1">MIPLEGEGKSVTLDVSLVRKLNGLTLDYRTPFESKSDHSVFESTGSPSVRSHEQWFIQIGPSSQWQAISSPNGLLKAVRTKQSRVPQKKLVIGKVDFESNEDRKRILDGLVEIKPGGKFEYTKQIIKALKNAKVWTELGGYKTFKSMYKETEVPIGSHSFDDLDTLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4W5</accession>
    <name>A0AA38J4W5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1098559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4W5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3718119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="18664" checksum="8CD008806C51CB84" modified="2024-01-24" version="1">MSHHDRALRLPIIMAQPQPVSLTDLDLTQLGEIKKQFEEELNHLTNSFAQLKQAQAKFKACIENVAEINLQNQGKTILVPLTNSLYVPGKLNDPEQVLVDVGTGYFVQKTRPQATKHYQNKVNYIQTNLETLEDTIQKKRDNMNAVVNVIQVKLQEQTRNTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5Q7</accession>
    <name>A0AA38J5Q7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1088968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5Q7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="94" mass="10595" checksum="3C8A5325A7A2827C" modified="2024-01-24" version="1" fragment="single">MFCISSLCVFVFCFFGSCISYFSCTARLFFFFLAFSFSFSFCFVRSLLSSNAMLCYVMLCYAMLPLSLIIISHLASLISVPHKTIPNPIPIPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J655</accession>
    <name>A0AA38J655_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1157813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J655"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3724287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="284" mass="31373" checksum="14A74027581D30F5" modified="2024-01-24" version="1">MIAKIQDSYLSWHDRNTPASILATTPVAVHPGYANSATPSSQQAAFILQELPGVTLDWDRQLFTITRLDTDDLTFSTEEMISCILASLAMSCRWRMEQGAPTRYDEIARTLVSYIPTTSMANFSIIHNGELWKSSQPVTYDCIFSGPQVTELTQSGAITGNIYADVKWAYPKPSRVIQSSDKDSGLLADFFAVHSTKSDQKVLLNGIFAAAKDTERTVAWRAKRNKAPRSLRGTQRYAETAASSVNIPSTTASVTEKMRMWRFRSGTRVSEDMDSASEAAGPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6K5</accession>
    <name>A0AA38J6K5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000111">
        <property type="protein sequence ID" value="KAJ3712117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6K5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="578" mass="64140" checksum="E5D4368BF8E619F5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J719</accession>
    <name>A0AA38J719_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_561634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J719"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46983" checksum="A4658233E8F2D1A3" modified="2024-01-24" version="1">MDPSMSTTSHDRRRSIRRTKPPVITSFTNSTTVPNSSILTKRNSPSYKSSSLELNPAVKGASTKAKSSLSVDKSDLQAPQLHDLVRKVIQALEGLTGAHWDMEVLGLETSAEEENDNKKERGDQEPEKRNSAKGSESEDEMEAAKELLLNGNGVAHVTEGKKKVDWEIPRKLLHSSIGFFTIYLYLSRGNAKVVVYTLWSALCVIAPADYLRFKYPSFSRIYERHLGFLMRESEKTTTNGVIWYIIGVNFALTFYPLDVATVAILILSWADTAASTVGRLWAGHWGLYTPRLPSRLPIVPFLPAYLRHRLALPLAPRKSLAGFIAASFTGACIAFVFWGWIAPIPLRVERGDVTWFWDEGVFGSGVFGGWLSLGLVTIFAGLVSGIAEALDLGSLDDNLTLPIISGGCLWAFFKVLGVVSRSWISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J791</accession>
    <name>A0AA38J791_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1089476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J791"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="160" mass="18386" checksum="899FB99F4E0B022C" modified="2024-01-24" version="1">MSTEPKVKAVHFDVETALSATTHSRPLRKKSRIPTFSSPRAYAIVMPFDEMLARAKKENPDVQKLIDERGFRQEIAAVNLMVAELCDQACEIWPNAFMVVVDERSFRAPLQCIGLADNTHRINRTLPTADEIQQIRDRLDINGAEFKLGWYRDMYPDQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J854</accession>
    <name>A0AA38J854_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1134541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J854"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3716723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="467" mass="53119" checksum="4F459CA6F09CAA14" modified="2024-01-24" version="1">MLNLYTTPESSTYREWQQSSIQASIVLRKNHTQVSTPTSKIHTRNAKSLPVLASAGPKAYSCNEYIEKRKIPVNPFGSWAKSLLETHPDLKDEVMQHLLSVGKYVQAHDINDVKGKYGLEDTIPISTAKCWMKELKFHWVRNHVGQYVDGHERADVVHYRQEVFLPAWYRIEGKKRSWTADNVEELAQWVADGVSPEPYAKGEGISLMVADFVSADYGWLCSKDGKELARVIFCPGKNCDGYFDNDDILAQTYHVFVFDNATTHLKRAEDALSAHKMPKFTPKEGTNWGVEVTLKAPDGSTVYDEKGKPKKTKIRMTNGKFADGTAQEFYFPAGHSCAGIFKGMAQILLERGHMNAHALRSECPKFKCDPLLEGKCCCRRLLFNEPDFAADCFEVLFFPKFHCELNFIEQCWGSAKRNYRLMPTSSKEKISDLITMFARRSRRFMDAYHQGLTGKQAAWAGKKYHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J948</accession>
    <name>A0AA38J948_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_478172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J948"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38834" checksum="D80BAF2282CC39DF" modified="2024-01-24" version="1">MFSRNSHLVSSMHSPSLIQIVDVKPSQQIYNYVVDCVADAIDLILGQQPIISHRKREARRIQELNDFTAFVSIVLIRAQVTTPVILSLLVYIDEIKANPQKLRAVLRNKFAIYERIFLGALILASKYLDDDAMQKNTEWAACIPYFGAEDISLVEDDFLAALQWNLTIREQDIWGHFAGILGVYAPPRSTCDRSPHDNSPVELLSPLDVLCRSLESELTYSVSHTDCSNSPGSDHTTMTAVPDDCPGFESSSPSSSESSSSPRTPANVPTAIVIDPKAHLRSKSDALKSYPIPSASTSTLISNTSGQIPACQTTTNPSLHLRIRKWMKYMNDNIHSRQHHDTQKTLMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J960</accession>
    <name>A0AA38J960_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1078043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J960"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="216"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="436" mass="47913" checksum="E01CCD00A51D4819" modified="2024-01-24" version="1">MFKLQEDETPYVVQSSDIMPIEATFLGEALNREKSIAQSVKADTESATTLIALEESYPEGGLRAWLVVLGCFLYACTVFGWGLNWGVLQDYYHTTMFPNTSLSVLGTIIGLANFTMNGSSYVFGGLGDRFCFLAYLCLLASAFVTKVYQLFLFQGCLLGLSQGIGMPLYFSLCSQWFLKKRGLATGIAVSGSGIGGGIETLIMRQLISKIGYRNTILTFSSLHAVIWIFAWFLLKERLPPGTNPTAKKLWLPKKITGSFWSVALSMFFGVFGYLPPYYLSTTYTRQMVPGLSTSSLLATITAGRLADIFGPINMFFCSFFVGGLLQMVFWTFARTYTAIIIFSILNGLVGSWFMSLLPVVCARLFGVEGLSTITGFMILANSPGQFVGTTIAASVLSTSGNNWKAVSVYSGSMQIIGALSILYARFHRERRVFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J974</accession>
    <name>A0AA38J974_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1078315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J974"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3731636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24910" checksum="1E50D26C4C943F42" modified="2024-01-24" version="1">MYIAGIHLSHAQGIESIVTASTIATIAVIVRDQRRTFRKASKEGGNITAGPESFVERIVTPIHGSALLLAPFSYLVAVFSNRMEQPEWYERTAFDFPLSVGPLAWTRTAAAVGLLGTAWMARAILKSLGKQLHFIGTREKGEVVTTGPYSVVRHPLYSLALGQFIFASVAYWSWIPLVSFGVCLGAFAYKIPVEERLIEHDLAMGPAYLEYKQKVPYKIIPYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9N9</accession>
    <name>A0AA38J9N9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1159407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9N9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3718617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="559" mass="61599" checksum="DF96A3263DFC2DB3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9P1</accession>
    <name>A0AA38J9P1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_323422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9P1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="547" mass="62072" checksum="D06EBFD2D5592B89" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9X6</accession>
    <name>A0AA38J9X6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1006632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9X6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="70"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3716821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="268" mass="32128" checksum="5609740460543BF2" modified="2024-01-24" version="1">MINPFNLFFKSSRYWLIKSISKLLTSGTRRVEFADFWMGDQFCSLVFTLSNLYLFACSYTIGFENWRKCGSAARTWPAAFILAMLPFLIRVIQSIKRYVDSKLNTHLINGGKYLCGIIYYLCYYIWRHQGSLRNTSFAFWCLFGTLYSVYASAWDFWMDWSLFRPHVKYPFLRAELLYTDHIPLYYFAIISNALIRFIWVIYIPSASAPNMYLRFFIAGFLEMLRRWQWNFIRLENEHLGNMDQYRVTREVPLPYSFDDNHLRDTDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA72</accession>
    <name>A0AA38JA72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1072789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA72"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041337967" evidence="3">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="346" mass="37220" checksum="6D941A1AA1B075B5" modified="2024-01-24" version="1">MLLAWLLAFLPFIIRTVSSVNVNGPKSTGPPGTVSNEATATWILQDGDASLSSGFSMVLVNDNAGVTTEWSTIVSPQGQSTGTVHFTPSVAGPHRVEVIPFGSETDKGSSSEFTVLQNNGSNSSDHNPSVPSVPSGPGDSSLPTSDTTGSFHSSSSPSVTSSRYSPTSTPTTTTATSPPRTGFDEYSVAIVLCAIFGTVLLGFLLLAVILLLRRRRRLRFSANQIRPARHHSERFHWSSPQTASGSSTDVSSELFETSKTAPMSVLNAPESWDTSSIAPSDSVSRLLSLKRFEGRQLERHHFSPADRSRNKRSIVDWSDVGTDIVEETNWVHAGGPELIPQIRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAB7</accession>
    <name>A0AA38JAB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAB7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041297306" evidence="1">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="206" mass="22748" checksum="E3FCD428E25DB8F1" modified="2024-01-24" version="1">MRLILQNASGSHACFLLILGVFSAVLVDVQVVALPVSGTNISNIVSDLDSNSTGSNITLESRFDSNANVPNLHARNEPIHATITFGPIDASGVGNEEAQWVQLGNKALIHMAKEEHDKKGEYPLTYSYQNQPKVSQDQEYHHFNVHLEGWHWGIQPGVNPNFAGLVKWDDKHVDRGVITGHITGQLQISGQVYFSADKREVKFNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAI5</accession>
    <name>A0AA38JAI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1181081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAI5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3732461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="488" mass="54214" checksum="F2F177E8E09EA097" modified="2024-01-24" version="1">MSNERAAFEAEVKQVEQWWKSPRFARRGTIKIEYPSNILAQKLFAFYCQWPQMAKYLETVYVSGWQSSSTASSTNEPGPNLADYPSNTVPNKVEHLFMAQLFHDRKQREAWSNMSKSELTKTPVIDYLRPIVADADTGHGGLTAIMKLTKLFVEKGAAGIHVEDQAPGTKKCGHMAGKVLVPISEHINRLIAIRLQYDILGVENLTVAQTDSEAATLITSNIDDRDHAFILGSTNPSLPPLNKTIVDAERAGKVGDELQAIEDNWKAAANLQLFSTTLAQALRKEGKNDTTIQNFEARVATSSYLDAVVIAQKEFGLRSVPYWDWDSPRTREGYYRYQGGTECKPILSQAQKFAAGVHAAYPGHWLAYNLSPSFNWDAASLNEKDMQSYVWELGKLGFVWQFITLGGLHSNAYISDLFVKEYAKTGMKAYVELVQRSKERELGTDVLTHQKWSGADYADNMLKAVTGGISSTAAMGAGVTESKFGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAZ7</accession>
    <name>A0AA38JAZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1042762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAZ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898:SF13">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3719118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="522" mass="58442" checksum="47179F91610EA0F5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB00</accession>
    <name>A0AA38JB00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1157897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB00"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="232"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3724205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="495" mass="55486" checksum="A336439B2DF028CE" modified="2024-01-24" version="1">MSQGKQLYEKSAIVELDAAEDEDEDEEDSEDGGDNRFLPNDSDDSGEKDDIDELKDLDEEDLTRERVKVVGKKGGYNKRGSLIQTVHGNNVDFIPPPSQPASLTNNNNSSYCSESEASSRVDLSMMPENYDSEEDEPAPIAKQKVSKARDAKYIAELPAIVPPPMETQVIQKPIRKQVAHSHISYTSHVTAAMAADPNDDWPNLTALIYPRQQRVISLTAQTQTAQRVLHEAINLAIGLAIFQNGFAPTAQQLADSKNSIMLVATKFELPDIVYRFERDDLYAWHLITYVTGQVGHMRGKVKDAAQELVPSMYGIHQIPVENNTRKSFIADLLTKMNFIFPRTNVAESSTICTSEPYRHPAIVAVMRKYFFFGHKSLGHHFHDTFLSSVNSNSSKEIPRAMLGIVIVAIFAALKEWSEGCDQRMTQDFVSAEFSDEYDLHMSLLQSRIHKEDGLGKHKYHSLMSWLYREACMGEGSNIKASSDKMPELDFDGMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB23</accession>
    <name>A0AA38JB23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1068263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB23"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="925" mass="103550" checksum="DFEBC4A18B9C05DD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB54</accession>
    <name>A0AA38JB54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_229395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB54"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34111" checksum="E5129A1580D4E829" modified="2024-01-24" version="1">MVVMDFDTAWCPVCDRQIAPKRITQLVTTDQRPATGTNGPARQRNAQNRPVTKTKTVIDQGPYPLYCSDECKMADMLHQHEDVYAPPTYPIYHSSTRSCSLSKSDNTEGSPPSDIDSDCLSSTTTDLSYPSPTFESAVLPTATQSIACQPKQRSRSFLTGNPSRSGPRHIPSSLPTTSTISSAFGDHEGKSTPPTQDDFLLSQFQGSFTRRSESRVSMYSGPSSPSSRSPPFTSALSTSPPRRERPLLPHSAQGKLLVPDVYVRVPTRPPTSRRESSSSLASMASISSAPGAFTSRNRTGSMASIGSSRASLKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC75</accession>
    <name>A0AA38JC75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1096813</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="103"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="196"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3719672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="296" mass="32266" checksum="861AB4BD2F7764D1" modified="2024-01-24" version="1">MSDQPKKPLPFVANFAAGAIAGISEILTFYPLDVVKTRMQLSTEKSQGFVGTFKNIIKEEGAGRLYRGLVPPLLLEAPKRAVKFAANDFWGKTYLGLSGEKKMNQQLSVLTGCSAGATESFVVVPFELVKIRLQDKNSTYAGPIDVVKQIIKKEGVLGMYNGMESTFWRHLWWNGGYFGCIFQVRALLPEAKTQQGTLANNFISGAVGGLVGTMLNTPFDVVKSRIQSAPKLPGVAPKYSWTYPSLAVIAREEGIGALYKGFIPKVLRLAPGGGVLLLVVEFTLDIFRQALGPPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCA7</accession>
    <name>A0AA38JCA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1086326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCA7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000636">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="111"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="12">
        <location>
            <begin position="1093"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="424"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="823"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="879"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3727325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1144" mass="123936" checksum="3726349213A2A353" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD74</accession>
    <name>A0AA38JD74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA topoisomerase</fullName>
            <ecNumber evidence="3 11">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1008397</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 11"/>
    <dbReference type="EMBL" id="JANVFO010000105">
        <property type="protein sequence ID" value="KAJ3712774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD74"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="15">
        <location>
            <begin position="163"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="817"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="641"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="641"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3712774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="885" mass="97299" checksum="9B469BDB405BFFA4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDD8</accession>
    <name>A0AA38JDD8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_663265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDD8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041344912" evidence="2">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="152" mass="16461" checksum="741759E93C44F783" modified="2024-01-24" version="1">MKTAFVSSLAVVAVAMMTITAQAAALPTAALPTPTIVGNPSAPMSDSDKIQSDQGGFRASGDNSRYIHLNADGDPLVDFDWRQKQSGSSRFASVFLNDPSIRSLISLAVNTNRSNLKVLKCPNPKTSRKKLRKTISGTFFFPILRINSFTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDF3</accession>
    <name>A0AA38JDF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1158241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="146" mass="16751" checksum="C4007BABE274CDE5" modified="2024-01-24" version="1">MMLNNEGRLEIEEETAKRAEKLRTETEWQKQKSDAQRMDIVRQAEQDRLGSEFSGNMKTMTKSKLIDIAFVLKVPHEDATVDTLRIRLNAHFDANPALKKEPRCIGLFERTRKRKDPPQEDTTRLPPPPAFQSHPLAMPGTSSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDH1</accession>
    <name>A0AA38JDH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_659719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDH1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041403072" evidence="1">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="197" mass="21973" checksum="8BDEAF50C573F289" modified="2024-01-24" version="1">MRTLHLSLLCLLLAICMASAGPCPVSFLNQWYRTTLLSKDVQLTKPGLQHFQTVSYNTKARDPGVRPYFVKPTFVTWSSIEPPNWLLIQDALKALLLQDATSALGLPAEAIMDYTSEQSFPAHNGKDVYSPIEFTVNAERCKGKGVLRALRKSVCEVQADPKALRKRVIIKDSGGDTIFSKGQLEWKEKGEVRTGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDN1</accession>
    <name>A0AA38JDN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_670890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1341" mass="146089" checksum="DD150C3F8929E101" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDQ5</accession>
    <name>A0AA38JDQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_663782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDQ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="359" mass="38938" checksum="90AD017A030B0542" modified="2024-01-24" version="1">MSSSYTSKAPAPLCLCSSPRGSKPPQLELNLGSISPLRILSTYALQDLEKHCEHDTTPSDASSLSSFETSSTCSSPSLDGSLDHLTTPLQSLDTRGNEDVFSASCRKDVRPLPPVPPSASASSPTPTISPKTRPLPPTPYLKIDDVAISVTLATPMTSPVPPAESPHHLSPPRIRRLPNPSAFALSPQAASDELPASGCENLCRLNTTLMLGTVSPDAALHRRLTKLKRYLGEQVPNDLVPVISSARDPLAAKDLLVRLSTCPGLEDTTHAPALDPAVISRRLKELEDDKSLSDEEDDDLVFVEAESPVEGSQSWSAGVNSTFHAVPLHRYSKKWVWEKKGRRREEQDYAYILRALRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDT3</accession>
    <name>A0AA38JDT3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division control protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1147311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDT3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3722788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="381" mass="41847" checksum="C96CB0685AA16331" modified="2024-01-24" version="1">MNFQTEAPSSKVWNLSTRKHISLPIHGTSIVTCLILDVLRNVIVTASDDFTLAVYTLSTGQPKLTLTGHEGGIWSLFSVTYDGQNLLISGFTDRTVRIWDLTSGKCLHVFRGHSSTVRCLEVASPIWTNSNMDVENVCSQSPLIITGSRDKSVKVWSIPGKDEPSFVANEDLNAKENPYHLLDLTGHTNSVRSLSAHGRTAVSGSYDKTARIWDIVTGECRHVLTGHKDKIYVVVYDPIRDQVYSSGMDGTINIWSATSGTCLHTLTGHMSLIGLLELSSSSDPSPYLVSGCADATLKVWNPCEGRLDRQPRVLAGGDSILRMWDIQTGTVVKDLLEGVTSIWKVAFDGQWGVCAYAKRDERGLGQSMLDIWDFGSNDPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEU1</accession>
    <name>A0AA38JEU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1139999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEU1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3728132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="598" mass="63599" checksum="C8D679898F213B2D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFD6</accession>
    <name>A0AA38JFD6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_380133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFD6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="315" mass="36140" checksum="F7F268C0CE547E27" modified="2024-01-24" version="1">MTSVAENRISLPTEYSFVTLSLDPEATVSNLKNEELSAACRRLQRKTFVAFTGERRQFFMPWEPYHSWQFYLVFQGLREENVGQGIEPQMSVPILPNTTHPLCREPLDPGYALPWNDCYISEFIQFDARVATRVTEEEPVCCTTSEEATRIRAYFDEDIQRRRELEPQIVAVRAITGSDGIDCSDTESEAPWSSSFVDEYGSMEEAQYEDRESTPLRKGGESGARIMLDEMTSRPHSNLFVVEVSFDLSSTDQIHNPDNFFEEVAFLKKLTIELENARKQREIENAQRIDEEHFAAVQAARNKPPQACEHTQPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFX7</accession>
    <name>A0AA38JFX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1086920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFX7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3727196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="465" mass="52215" checksum="8975DA25522D49C2" modified="2024-01-24" version="1">MTKYPKVSGYDLVQQIGGGGFSTVFRAVNLEQNRVAACKLVLITDKTTEKDRKTIDKETRIHSVLKHRYVLELICAVTVELKYREVYVPGIYMLLELAAGGISPDVGVGDEVAHLYFNQLLAGMEYIHGKGICHRDLKPENLLLDIAGNLKISDFGLSAVFRLTNGKTRSLSERCGSLPYVAPELNSDEPYNAEPIDMWGIGVILFTLLAGNTPWDEPTRHSPEFRRYKAGDIFDEDPWNRLSENALSLICGLLTIDTRKRLTLPEAFQHPWCTRASQLARQSPAVLADKLTESLRATGDMDYVTPADRESPMDVDQEESDTEMQPAMGHNSQFTQSLMLFSQTQSGARYTPHLTRFYAALGPALLILIVKETLSGLGIVYKESPRQERHNGSKGIWKMRVGGKDARKIAFKGWIEMEEFSYGDGEIEGTFCVMSRDEGNPLSWRQFFKALVKAEAVFPHVLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGD5</accession>
    <name>A0AA38JGD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_683455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="60"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3721402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="559" mass="60983" checksum="0D923E36561119A4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHM8</accession>
    <name>A0AA38JHM8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_398374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHM8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="7">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="455" mass="51928" checksum="721F1DAFFCBD5B6F" modified="2024-01-24" version="1">MTFLQGIHFYLQPEILPELQDTLRRSITELGGEIDANVPDKGYVLADLHNPQSQQIFQLFTPERWVVPLTFVEACKAAGAYIKPIFLEEGVPMPIHVHESIANLKFREALYEKILFCTGFPYATLDSARVIIADSKTSVFSALVKHYQLTPHKYIESLEWVDKCIERQEVSFTPHVFKNPGGRRAGEERTQFTEEDERKLCEWIAAKIPFKSTGGRTGNKLYQQLCEMRNHPEYAWVTRHTWQSWRERYKKNAVRLDKIVDNIVSTTKPNQGEKWQYGYVRQDDDKPRKKRKHSSKHEEFIVGSSGAGKKPAHPGPTEQLSQAISANSSLGQLAGILRLAPPENGEDEWKIKIGNNLSPSWTKSKGSSEPEEDSDTKRAKSDEPPAMTDDTLQLAIRAAVAGHVLDHNLSEIAQQSRFTAEEVREYYDKCGGDLERTGRRFHKMREHLNALPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIN6</accession>
    <name>A0AA38JIN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_563489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIN6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="210" mass="22501" checksum="2182A52518EC7166" modified="2024-01-24" version="1">MHRTRQAVPFICRQCSQKYRLASTATKLQSGSEVSADANKWRLQKPVPQTNTSRDTGAASYSSSPVSNASSSPTSQGESSSAAGLPLRARSWSRIIPAASSPTNSVPTPAPASPNSTNKAAPAFRQQVMLDREEAPHTRPPPLSNTRAQNAKFPDRNHLLGQDNPNSRNGTSTHHLTNRNSSLISSVHPSTQTVPSTPASSNLDLWDVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIQ1</accession>
    <name>A0AA38JIQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_511743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIQ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="138" mass="15517" checksum="AFFA4A5ED2FC59E5" modified="2024-01-24" version="1">MLPPTPLSPLENEFREAVWEFSARVVKPKSEVIDREGGDSETHEYKTLIEVHKEMAEMGLHGVTVPTEDLTSSLGLGLSYTHHLLAMKPSPIPLHLSLFLTVLTLIYASTNCLAGARMTKERNGSRAYWTGRTLVRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJK4</accession>
    <name>A0AA38JJK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1077660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJK4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="950"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="950"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="964"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3731825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1095" mass="119057" checksum="93E4988AA4BCB2C2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKG8</accession>
    <name>A0AA38JKG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1081726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKG8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="70"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3730866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="574" mass="61358" checksum="A0FF8BEF9256F173" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKJ2</accession>
    <name>A0AA38JKJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid phosphatase/Vanadium-dependent haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1133734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF84">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="116"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3723504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="360" mass="39906" checksum="E34BB305110C3E1D" modified="2024-01-24" version="1">MPLFSNNKNTQAGERGDHFRLGVWLRLHGVDLITMALMGALGLGIYEAPPAPSRSFPVYFQDGEVVYPQFAYPLRKEIIPIYAAALIAFLVPFFFFTIFQVRRRSLNDWLTTTMGLLKSLITAAVFQVFLKWLIGGLRPHFYAVCQPNVQANVAPFGTGFASLMYDRSVCTGDKDQIDDSLESFPSGHSTAAWAGLFYLALYINAQLKVMSAHNSAYWKMILMFSPLLGATLISGALTIDEFHNWYDVLAGAIIGTCTALVAFRQTFAAVFDFRFNHVLLPRSTSLFHRNPFLVAGMQSPFFTYHVATEDLPVTREGGWGWGKEAFNGAPGDATVLMRGRQQGSGARNRPAEVPTNAYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKX0</accession>
    <name>A0AA38JKX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_449231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKX0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23051" checksum="6BC53A1320F74F2E" modified="2024-01-24" version="1">MQSGTSVRKSHKAEHRKTTSLLFQPCQILVDFSKPASGAITELAHGSFTPTSSAFPGLTTLATLHNPGTIFMHAGYTRRRQHSMFEWPEMHSEIGGSDTSSVPASPTSSSRSSRATSIPGITRTSSYDTHSSVSSSPSLSDETLLPTRLKPTEMNPILSDLERKSKLCSSVIGCATCGKPGSDYPRCGKCGEMWCSRPCRLRDGKKHLCISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL60</accession>
    <name>A0AA38JL60_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1079180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL60"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="417" mass="44061" checksum="E4F39B5399A06C81" modified="2024-01-24" version="1">MNSSAESPKEIVIIGAGIIGCSTAYQLTRHPSFSAATTTIKVIEASKHGPAQGASGKAGGLVAKWAYPKELVDISFAEHVKLAKEHNGQDRWGWRYVGCGSWEGKGAILSEDADFGDGVGAGGRRKSLEKTFGLEGGGRKSDPVSRKRKGLPDDLLWVDESLTHSYSPMAAHGDTAQVHPFLFTNSMMDLAIEKGAELILGRATSLNISDGKVTGVDITYNDSGKRGTLSATHVILAAGAWSPSLLPSLPISATRAHSITIHAQPSVDIAPYVLFTEIALPERRGLTVSPEIYARPGNEIYACGPGDDSLLPKNVDDVILDEVACESIWMHVSSISPELRAGTVDKRQACFLPVVETGGGPIVGAAPHIAQGLIIATGHTCWGISNAPGTAKALSELVMDGHIQCANLRKLEPSNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL77</accession>
    <name>A0AA38JL77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD-box helicase OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_264583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL77"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box helicase OB fold" evidence="1">
        <location>
            <begin position="94"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="186" mass="21279" checksum="DAD23FDBDF8F978B" modified="2024-01-24" version="1">MCSVQDIFIVPDGAPGALAELERRKFTAEEGDHLTLLNAYNAFTRYGRSSSWCKTHALSFRGLSRAVSIRAQLKKYMQRFNLPLESCQGDAKRLRRCLVSGYWRNGARWVGDGTYRSVRGNRTLYVHPTSVLFTRKPRSGWVVFHEMEETKKTQIRIITEIEPDWLLDHGHRYESNKVTGSAIAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLJ7</accession>
    <name>A0AA38JLJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1130503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLJ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3734719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="522" mass="57351" checksum="69A80D213CF362DF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLU0</accession>
    <name>A0AA38JLU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_995497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLU0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041337089" evidence="1">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="133" mass="14912" checksum="27CD04CEC50AF3F0" modified="2024-01-24" version="1">MKYTSSVMNSFAFFLLTIFFTISNAFPLSNSMNKRDVFIPPITYPDNTTVWNSGEVHNVTWDISQAPVNITNKIGRIQLRQDDITFPLVLAYDFDILLGSYNITVPLVISGAYQLVLFGDSGNFSPEFTINGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM00</accession>
    <name>A0AA38JM00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1025755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="730"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="929"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1178"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1277"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1394"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1295"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1308"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1427"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3732186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1455" mass="162895" checksum="6BA5EA51854749BC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM36</accession>
    <name>A0AA38JM36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein S linking to the trans Golgi network-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1151718</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM36"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="218" mass="24761" checksum="00827FFED2810864" modified="2024-01-24" version="1">MSSQVSSWDPILLISQIVSMQTLHYITLSIFIPPLLTVFADSASLAYEGGPSNVGMIMDWREMAGRPTVRDIYDSERWGSYSWAWSGGKILGFTWREDQLRGGMDPIRGWIIAFCWMLACSADIYYLYILVRRPRLILDFAVTLTFNHLVLTTYYSSSVPTSPFFWVIVIAGTAMTVVIAEQLCVKREMNEGLNVAPARAQEEDLDEMELGQLLPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM83</accession>
    <name>A0AA38JM83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1067283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM83"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3733468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="23765" checksum="F31FFE5728AFA3DA" modified="2024-01-24" version="1">MGISRSSRYKRSASGAQRAHYRKKRKFELGRQPASTKLGAKRVHTVRVRGGNLKYRALRLESGNFAWGSEHVTKKTRIISVVYNASNNELVRTNTLVKSAIIQIDATPFRQWYESHYAQPVTKKGKAVAPADTAAEPVKLSNHAQRSLDAKKKEAKIESLLESQFAAGRLYAAISSRPGQSGRCDGYILEGQELEFYIRKIRTGKQKHAHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JME7</accession>
    <name>A0AA38JME7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1117786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JME7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="149"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="310" mass="34769" checksum="5A4B28FDBB42225A" modified="2024-01-24" version="1">MSKDPQWLFPLEALHHSPSSIEPLDKTLYDLARGVEFLFRLGTSLKLPSPALFTAATWFHRFYMRYSLQDFHRQDVAAACVFLATKTEECGRKLRDVAKVYHSKLTNVDLIDIPSECKEVDQYQTAILVTEEYLLQAICFDFTVESPHAELVDLFVAIPDDRTVQDYAWTFAHDSYRTPLCILFPPRIIAAACFVLAQYIAEGPNSLPLDARISFSAPSASLPTPPSHKAASPDASRLAVEFFALSENDVQNVADALTLLLEFYSVQDLTMHPHLQDIAIVRPMIAPISYCSYNIKGPASKDKYSEGSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMS7</accession>
    <name>A0AA38JMS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1068423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMS7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052818">
        <property type="entry name" value="NEDD1_Spindle_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44414">
        <property type="entry name" value="PROTEIN NEDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44414:SF1">
        <property type="entry name" value="PROTEIN NEDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="89338" checksum="59BD530ABB505822" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPZ5</accession>
    <name>A0AA38JPZ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">DFJ43DRAFT_1051450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPZ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3736302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="658" mass="73070" checksum="8EEEE91401B05390" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ75</accession>
    <name>A0AA38JQ75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1051413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24527" checksum="0CBC3EF41760839D" modified="2024-01-24" version="1">MDVTAKFQGSIPYTLHSASPALAALHTRRTRKLSTTPTDPDSETYCCAKCGFYLFAGDSSTRVVRVVKNNRRQRTDAPTCTSNSNSRTRARQSTCLQCGWVNELSLDREPASLFPIRRSSLYSKTGDVEQPSIVAVKSIQKPKDAPVESRALSSRSNVQSTSSQLPPESSVPPASTPVIAKKSKSRPKKKNGLHEMLAQNRAKEEKTKNALNGGQSSLAAFLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQV8</accession>
    <name>A0AA38JQV8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1185815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQV8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="331" mass="36119" checksum="3EEABD6DD54C22F9" modified="2024-01-24" version="1">MAVSSTIIIVVVAVVAVLLLLLLLVSYYLFWSKSKRKVPLPPVQPLAHDRERSLHVYAVEKERERSLFLQIQIAPSWSEPGTIKSAVSSESGSTANTMGYPSVPPIPPGISSVNRHAPPRPLSIASSARTSRSNFSRAIPHAPDSNVQIVLPAPLGASTMDYSRDSIADGWVSQVINSSQPIRSRSRSRSQSLSRSYTRSSLGTSYVHTPNPNPSDLYVRNRSRTNSLPYSTSSSNQIPPIPPMPSQYSSSVAQIPPPPVPRTPSVYGQPSSSSLSFHSDAADAENEYRGRNRGRGPSQGRSFTSLEEASAYKSVQQNGRPKMRSRSRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRY8</accession>
    <name>A0AA38JRY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1035272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRY8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041212270" evidence="2">
        <location>
            <begin position="24"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="288" mass="28250" checksum="739743477B041680" modified="2024-01-24" version="1">MRSAFKFAFVFLLLSSAVSFAAAVDCPASDKNGSPLEAPGTDAGDGFVTCTYQASGACTYFGQNGEFSSGPSTCPKGFAQGSGATTSTEQQSSTTSKQTLPPETSTSAQVTTTTSTPPPPPSTTSTPPPPPSTTSNPPPPPSTTSKPPPPPPPSTTSAPPPLSSTISSTTSQSVVSTTSSSTSITVATLSSVTQISATSSTQLTSTTSVVTSAPSISASSSTSGFVTLPSASLSTSTVAAAATSSASAPLTSTAPAATNNNSAASILRQGSMTVVIGVVMVFGAINII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT38</accession>
    <name>A0AA38JT38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_996673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT38"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="226" mass="25034" checksum="013CDBF7C4938A92" modified="2024-01-24" version="1">MFSLGSDSVCDVCLEPFGADLKAPCSISCGHVFCADCLHHITRQTCPLCRVPFDPRSIVKLHVDLDIVKTASAGSGQASETSSAEQEARTLHERIAAVANAGTTEANLRSLISDCKTFLSSQPRNIFQDLRVSLRMIAYLCEVKSTLRSRNQTVDSLTEKLEGSQAEYDELQVRLLELDGARKEAVNARRKTEGEKKEVQATAVQRELELTQKVSEMQNKYIDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT44</accession>
    <name>A0AA38JT44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_824949</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT44"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="100"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3735685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="499" mass="55627" checksum="30833301E5181F4A" modified="2024-01-24" version="1">MPPSYEPLPSNDSEQDITQPQARTPQKSGKRLNLLFIILGFLVSAFVFYKAGQWSVSPLPSATSGESLSVPTEDVKENESVSDENNGTTTSSIDQTMPGKYSVGYFVNWGIYGRKYPPSSIPVQDLTHILYAFANINPSSGEVSLSDLWADQDIHYPGDSWNDAGTNLYGNFKAIYLLKKANRHLKLLLSIGGWTYSPSFHPVVVSPSLRAKFVESAVKLLEDYGLDGLDVDYEYPQNDAQAQGYVDLLRELREALDRHATNKRADYRFLLTIAAPCGPDNYNKLRIREMDQYLDLWNMMAYDFAGSWDPVANHQANLHPSPTTALSVSQCISYYLSSGVAPSKLIIGMPLYGRSFLQTEGPGTPFNGIGQGSWEAGVYDYRALPLPGSHLMQDDKAKASWSYDYQKKEMISYDSENVGQWKGEWIKKMGLGGSMFWELSGDKGGPERQDMEGGHGKDVQPGQSLVKVVKEAMGGLEMGQQNWLKYEQSRFDNLRNGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTP7</accession>
    <name>A0AA38JTP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 2 Le.CYP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1049173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTP7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="497" mass="56220" checksum="AB6D08A83A9BFC67" modified="2024-01-24" version="1">MYYTSISSSLFASLVVVLIVAFVMHRAPSQSKGPHPPGPNVANMPTSDAWVKYRDWGSKYGDLIYLPRWNTLITNNAEVAIDLLEKRARIYSDRAMTPIMKLCGGENLLSVECYSDKWRKDRRVFQQTFRQAAISHFYPAQYNKIHEFLRKLLLMPEDSMKHIDGLSRGVIPKALYGLDIEPEDAFAKKVAGIIDTFGKALLNGSFPTYEWFPFLIYLPSWFPGCGFKRIASECGKVVKEVDTIPFETAMNNLHNGIGTSPIVELALQKPQDIEEIKAMGAMSFIAAIDTTMSSVSSFMLAMCLHPDIQTKAQEELDNVVGKDRLPTFEDRRHLPYVEAIYREVMRLDPPVPLGFPHISMEDDFYRGYYIPKGCAVVANIWAMNRNPNVHTDPDKFLPERHLESPTGPFESIDNIYAYGFGRRVCAGRYMADNTVWLTIASVLAAFTLGKAKDGNGNEIDIPGEFTNHFFRHPKPYRSSITPRSQLTRYLVLATADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUZ4</accession>
    <name>A0AA38JUZ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_517657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUZ4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="74" mass="8604" checksum="B1804A3F9FBA71DF" modified="2024-01-24" version="1">MNKPRLSLSNAGRFINVTLSCKTITFGSSLLPIVMTHHFLSFLQLTTIVFHYLYISHLAYVSIRTEYRKSFFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVL1</accession>
    <name>A0AA38JVL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1048964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVL1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="369" mass="41108" checksum="85C6063BE2C0275A" modified="2024-01-24" version="1">MVFISGLSSSSPSSSSSVSPSKPIHSSSLVDPEQHSPYLMQLLGLDISKPVIDHIVDYVSHIIGQSVDHSVDQPITLFPMTRGRSQSRRQPRPTGPVSDVRAFVKRVLRKSRVTMAEVLATLAYINRARPYLQVSGDSKYPFERVFLGALIVASKFLNDSCLSNMHWAQCTRLFGKHDVGRIEREFLEVIDWELRLTEDDLLTHYEPLILATFSDAPDAPLSESIDQRPLKLPIFQECPLVEEAEEELSLSPLPSFPSSAHQRSETNQPTRLPLFMHNSSPSLSPRAPLPSPVSPLTPDLEFEGTNCSFDTDSNSSSSPPPLTPPSSLAVEVNEDRTKGSDSFWDTFFSSMRLQEASSPIERFRERTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVN5</accession>
    <name>A0AA38JVN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1018741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVN5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="515" mass="58429" checksum="D29C4AADDDFFB3F7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JW79</accession>
    <name>A0AA38JW79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Laminarinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_527109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JW79"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041273680" evidence="1">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="12"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="311" mass="34435" checksum="51E2D24DF138BB45" modified="2024-01-24" version="1">MLLYFVSLLALQLVSGTSYTQSDSHTGIGFLKSFSYQAIPDPTHGRVNYVDAVTAANENLTYASGDHFVLRTDFWSVLDPDGPGRNSVRIQSNKQYTTSVMIFNIRHMPQGCGTWPAVWTVGEDWPNNGEIDVLEGINDQGPNQATLHTTAGCTMPDWRYEQGNALLDDCDALINSNAGCGVKFVDTRSYGPIFNDNGGGWYAVERSEAGISVWFWSRDAGTVPYEVEVGNETVDTDNWGEPSAYFPNTDCDITSKFGRHKIVINLTLCGDWAGSAYGDSGCPSTCEDYVNNNAWAFEDAYFDFQWLKIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JX75</accession>
    <name>A0AA38JX75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1049588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JX75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="85"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="253" mass="28615" checksum="B9BD37479688A71F" modified="2024-01-24" version="1">MVEPVAKIRSYRIEDEKQVRFVIAKAAMEGLASANMKTILNPLSLSLWVLLTGLLIQFMGWWPKSGDGILAYISLMLPFGSAAVPVILFSDWNNRWYFDDLSQHVLRGPDMVNLQEYYSKSPASGLWILEFAGRLVGIIALDASPLEKIGSNQKVHDTAILRHIYVDEQYRSTGIQKDLIDYALQNAFTASNSAVTQVKASSSPLRDYVRKALDETGFKYEGVSENIGLFRWKMSNRVLTKDEWKKKMTLDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTG9</accession>
    <name>A0AA38MTG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1077216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTG9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="162"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3731744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="671" mass="74228" checksum="069C8E6F0362F926" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUU3</accession>
    <name>A0AA38MUU3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1008446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000106">
        <property type="protein sequence ID" value="KAJ3712741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUU3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3712741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34410" checksum="DCCA2DDF66453BDD" modified="2024-01-24" version="1">MYSPNRVWFITGTSSGLGKALTDLLLANGERVVATCRNPATHDDLSAQYTNQLLAYKLDVTKEDEIKAAFSAGVETFGRIDVVVNNAGIGLFGELEAVPEEDARYIMELQYWGPIHVMKEAARIFREINPQGAGGRLFNVSTVGGYRANPTLSYYSASKFALEASTQSFLQEMHPSWNIKGCILEPGGFRSEWVTGHNSRVVPPHPAYTDPSNPTSLFRQAHGRIPFLGDPVKMAKAIIRLTDLSLPLRVQLGSESLFLVRMQAQNTLADTEKWEWISHSTNADHMDGENYVKQYLMGTGAFEDVDKSMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV14</accession>
    <name>A0AA38MV14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1152622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV14"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="55" mass="6338" checksum="202C9F7834E018B8" modified="2024-01-24" version="1">MYYTYLARRKTLFAWLAIQGGLATFVTSQYLKPKSQLSALGRVYRLQQQNAQASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV33</accession>
    <name>A0AA38MV33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1102883</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000087">
        <property type="protein sequence ID" value="KAJ3714915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV33"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="69"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3714915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="471" mass="51665" checksum="26608658A160C6CA" modified="2024-01-24" version="1">MCNHDNGDSQPKDVSEMVEVPLTNGATNGHVNGKRSPSRNPHLTNFIESQRRNPYAPRASDFLSNISNFNIIESTLREGEQFANAFFDTKTKIAIAKALDAFGVEYIELTSPAASEQSRADCEAICKLGLKAKILTHIRCHMDDARIAVETGVDGVDVVIGTSSFLREFSHGKDMTYITKTAIEVINFVKSKGIEVRFSSEDSFRSDLVDLLSIYQTVDKIGVNRVGIADTVGCANPRQVYDLVRTLRGVVHCDIEIHLHNDTGMAIANAYTALEAGATHIDTSVLGIGERVGITPLGGLVACLYAANPEYVKSKYNLPMLREIENLVAEAVEVNVPFMNPITGYCAFTHKAGIHAKAILNNPSTYEILKPEDFGLTRYVSIGHRLTGWNAVKSRVEQLGLKLTDDEIKDATAKIKELADVRTQSMDDVDSLLRVYHSGIQSGELAVGQKEALDRLLSKHRSQSQDRALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV36</accession>
    <name>A0AA38MV36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_836890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000081">
        <property type="protein sequence ID" value="KAJ3715943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV36"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="246" mass="27518" checksum="9D96B3E368C44DE7" modified="2024-01-24" version="1">MASSSTSTDGTATPVPLQRSSDSVGSKQATLESLTNTLSKLETDFHALNVSNSSDMNDFQLQTETELTNAKKARQLHDDVVEYRNAHKDKIDEIKSRIRETYPNQVAQQLSPEIQDQIKAEVQACTKDEVKIQFEKLMPISLRQQLDEINGQLSTVKNAFSNSEARSSNSSIDIVDAVTRKDKLKPVLKPDGTKSSFWPLDLISLFAYDPETVKKLLKDYELPIDKAHDTNLNSFLGYIGIKQQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVJ5</accession>
    <name>A0AA38MVJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation protein SH3-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_993055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVJ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="254" mass="27639" checksum="E23FF24EA4BC6B74" modified="2024-01-24" version="1">MGRVIRAQRRSHAIFKSHTHHNKAPAQLRKLDYAERNGYIRGIVKEIIHDAGRGAPLARVVFRDPYRYKLRKETFIATEGLHTGAFVYCGKKAQLVVGNVLPISQCPEGTIVCNVEEKIGDRGALARTSGNYATVIGHSPDDNKTRIRLPSGAKKTISGGARATVGIVAGGGRIDKPLLKAGRAFHKYKAKRYNWPRTRGVAMNPVDHPHGGGNHQHIGKASTMARSAVPGQKVGLIAARRTGLLRGTVKVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVK2</accession>
    <name>A0AA38MVK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_805818</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVK2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3716810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="138" mass="14568" checksum="BD056D336A898CEF" modified="2024-01-24" version="1">MSGKGKSGKSSGGKAGGESSGKSQSRSAKAGLQFPVGRVHRLLKKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKQRIVPRHLQLAIRNDEELNKLLGDVVISQGGVVPHIESQLLPSKTKGKKDEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVS3</accession>
    <name>A0AA38MVS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1062151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVS3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041356215" evidence="3">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="186" mass="20858" checksum="5B081F32E811C523" modified="2024-01-24" version="1">MTKLWLLAFLFICSSFLCSQAILNKWEATNFCKCICFQSNYSILHLTLPDTPSQPCLSCTKQWCLNQNLAICAGASLGDTDPDTATGKEGDVEARCFQRDSPRDQLVVTIFLLIVFGLLLGAGIKRRLEKAGLDVGSTWNNGVTWWEHLRARMPVEEFGLSRLGNRPGHDNRSRREEYIPVSNETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWB9</accession>
    <name>A0AA38MWB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_746029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWB9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044520">
        <property type="entry name" value="ARF_GAP_AGD5/15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419:SF3">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46419">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3719136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="502" mass="53629" checksum="F32CD5CB26CBA7DA" modified="2024-01-24" version="1">MSSHKFTNDRNLKILLGLAGQPGNDVCADCKARVPRWASHNLGIFICVDCAAIHRKIGTHVTKVKSLTLDSWTKEQVERMKEMGNLNSNAIYNPNELRHPPPLMLTEDERDSELEKYIRAKYEYKKFFDKHALVASKLGPSRSTSSVTPQKTTPASATSAANSSRPSTAALPPSSAPMTQTRSFSQPVPSPIPPASTQSASRQQQQQLVPASTSANGTSVWNDLVSLQTPSVNSSLPLQYQPPMSASSGSANHFGVMTSATSSPMLTGVSNMNGAGMPMNGMGYNLAIPNTGLGTGPNGLTINAGLPMGTGIGSAYNSPFPSGIPSTNPFQQTQLSATNPFTQQQPMSANYPPSALSSVPAGLSTPFMVQQQQTYYSQPSPMMQMQSLQSPAPMFSPSPQIPNLNLQQSQLQFANSMHYGGHSPQPQVSTTPQPPMSATPQLQGQFMSPSPQLQMGMGAGMSIGAPPAQQTQMFSTNGSWGQQQQQSPMFATHGQVQQWGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWM8</accession>
    <name>A0AA38MWM8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1006497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWM8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="68"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3717211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="157" mass="17315" checksum="858092CD0A6EECD3" modified="2024-01-24" version="1">MPMFANANQFSIHGGIYSNIGRDQINVHEGPLEVLSEHIKDVGAAHDSALRYPPPRCHPETRKEVQTTILKWIQSRANKLPVCWIYGPAGVGKSAVAQTIAELTATNDLLGASFFFSRHQAGSCAEYLFPSIAYQLAVRIQKFNDAITHTLRENPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWV7</accession>
    <name>A0AA38MWV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1006134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWV7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3717612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="61985" checksum="A2C7B68529D338B4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX77</accession>
    <name>A0AA38MX77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1089768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX77"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3725079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="433" mass="47484" checksum="5FDAF62492867E9D" modified="2024-01-24" version="1">MAQNMLPTETQILIVGAGPTGLAAAISLICNGVEPYNITIVDCLEKGANTSRAIGIHAATLEALDTYGCASRLVNLGIKGQAWRVASRSSTIFQANFESNAPYTEYPFVLILEQSATEHVLEERLEELGVEVKRPWRVVGMKDSGDCRGMDVTFESGETIRTKYVIGADGARSAVRQLSGINFADPDGKSIDDSIDDRVAQMVLADVSISLSEEQSAVLASGVSITVSDSGMFVLIPLGKPSVSELLYNSSEAVYRVGFTVPRALGEPPSKPSLEYIQSNLDQQAPFVLCSDPKLNPDPVRITKVHWSTRYRTRSALADVFFKRVHGDATGLGPILAEHSIRTRERQNSIKLHASDGRDADPEVDTTALEIYAASRRKRGLDTIRLTKNFLNVINFVMKPRLLNWPSWIMIFLSHVSMIKSRLVYRLSGLGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXH1</accession>
    <name>A0AA38MXH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1049763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXH1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="113" mass="12814" checksum="1C7B2648256812D1" modified="2024-01-24" version="1">MATADAPPKIRIMKGAASDLSAATYQVHDESHTMGNALRWMLMKNPKVEFCGYSVPHPSEPNIQIRIQMYDKLSSLQALIKALDDLDNLCDSIHEAYIESLQNDDYEKWDEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXJ4</accession>
    <name>A0AA38MXJ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Meiotic sister-chromatid recombination aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1140348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXJ4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="99"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3726409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="641" mass="72272" checksum="F456F5784315AA00" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXR0</accession>
    <name>A0AA38MXR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_568127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXR0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="86"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="86"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3726408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="449" mass="49672" checksum="EEE07833A34567F1" modified="2024-01-24" version="1">MYSTQPHFSNFSLHSSSPSSPTSHYSDRLPSQISLPEARLSRYTLPEFYQPTNNSHSPYNQSPSDTYSFATTTEAELPVPDIRPRVPRPPNAFMLFRSNMLKTKAIPATAEKRQQQLSKVAGECWNLLSPEEKQVWHDEAANQLREHQLKYPNYKFTPAARGSSRKMKKDAGQSAKTDKDHVRELREKWTHIYGPAVTPSRRRKPKQKDHHLSKSQPDLDFESLFNDPALAVTVSSRSLPSSPASSVSDSSLPPVFPNPSYPHYSESQPSNYRGFLMNEYPFPRPPSTSSNSSCDGSVASSASSFDAPSFDLTSYSPRSDSGLCAGFSNLDITPTAASFRESDLHPQPLNLLRQPPSFISLTNERASSEPPFLSPLVPSPSELPTNFLERTAAEGTSGGPASTCFVPFSYDSLKPDESNLSSFGPFPFIDSDLADVGGWNFTGDGNYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYD5</accession>
    <name>A0AA38MYD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1082610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="596" mass="66512" checksum="2E5358B08C49A14D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYG4</accession>
    <name>A0AA38MYG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_455647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYG4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="262" mass="29427" checksum="B28C1D366477AC7F" modified="2024-01-24" version="1">MSSAIKAAKNIFRFFRPGGTPHIYNSSIPPLFQRRSPWWAKWTFGLVACDAFMTGSAMDLTWNHWSEPIDGKSESEVPSHPEYYTLRPIWQRLGLCAGFFVGGVGAASALFIAGFRYTKVLDVYPHLQTIANPSRLDKSVVRKALEDRRVFIQSARHTRSRGMTFPLSQCTLHRGRADSELLLTIDNERGHWYIGLDNDSVINGQNYKGSAAREVILKAWKGGWINDDLARAASLPVPTSQKKKGGEAKNQKPPMNRPLHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYY8</accession>
    <name>A0AA38MYY8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_415625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYY8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041394605" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="255" mass="26035" checksum="928D6C32576176F1" modified="2024-01-24" version="1">MYHFLVKALALAFVTLDALIAVQATLYVIQPAAGSTCSGGSPCTVQWLDDGTSPLNSEIGVTTCALYTGDMQLVQTVPPVDVSTTQSLTFTPIPNAGPDSSDYYIAFTSTNLEINGTKYISYSSFFSLNNMNGSFSSPVASATSSIALPSSLAGSSTFSETTVLSTVTVGTITTSLFPTSTLSETASSSRFSTLVSSSASTTSSNSASISSGTSVSSSTSSSSTTGSSSSNSAVSLRKASLPLIGFLSFTVVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ59</accession>
    <name>A0AA38MZ59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IDO-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1187437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ59"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="473" mass="52683" checksum="BF78A2504D4DA044" modified="2024-01-24" version="1">MEFPFPILDANSPLSASTPPFTVSTHRGFLPINDPPASLPPSFAPLESLLSRMPIVTADGTPGLLASGNLGETVEKELPDLSEEVEKFKDDAAIMNAIYRDYSFLLSAYLLEPCHLRFLKGEGYGLGRQRLPAVIAKPMVKVSEIAGFKPFMEYAGSYALYNYRFSDPSLGLTYSNLRLVRAFEQGLDPTSSEAGFVFVHINMVSHSGLLISGGVEALNGASLSDRTRFDKGMKDMLEALKEINKVMDTMWNKSKPNGYNTFRTFIFGITSQSMFPDGVVYEGVSEEPMSFRGESGANDSMIPLCDNLFQITMPDTPLTEILQDFRQYRPGNHREFLQAVKDHSDKVNFRQFALDDSTSAELYLRALDYVRDFRWRHWCFTREYILKFSKHPTATGGSPIVTWLPNQLQAVLALMIQVEPYCTNNDVAGEAGIKDVQEIMDLVRSQQVTLSKEVAKYTSERGGGSVAPSVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZD8</accession>
    <name>A0AA38MZD8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1000775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZD8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="216"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="293"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3729109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="366" mass="39721" checksum="148A8684C6C50644" modified="2024-01-24" version="1">MAPYVTEFDLYEPQNADDRELPIQKIAVVGSGSWGTALARIAALNAAEKKGFDHEVRLWVREREIPGQGLLTDVINSTHMNHRYLPDVPLPHNLVAVSDLVNVVKNATLIVLVVPHQFLTPVLDELSKPGVLAVGARAISAIKGVEVAGDQIHTFPWLIEQKLGIPCSALGGANIAMEVAQSEFCETTIGVPSKDDAALWHAVFDSPMFRVHPIEDVSGVSLSGALKNVVALAAGFVDGMGYGGNTKAAILRIGLLEMAAFTKEFFPSSSSLTFSHHSAGVADLITSIILRGRNRKCAEAFIKTGKTFAQLEHELLKGQKLQGVATAEETYQFLLARERTEGYPLFTKVYKISFEGMDPKSLFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0B9</accession>
    <name>A0AA38N0B9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1080816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0B9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="138" mass="15579" checksum="9D9A6C8F4B3A209A" modified="2024-01-24" version="1">MTGYISGDELAEIIRSGKTPKKDYLVVDVRDDDYAGGNIVGGVNMPSKKFLMNVDQLVKETRDVPLVIFHCALSQLRGPQAARIYKETRQNVLSETDTTSPTKVLILRDGFTGFQDKFKDDAFLVENWDKDVWASDWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0F9</accession>
    <name>A0AA38N0F9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_996014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0F9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="156" mass="17181" checksum="2201BB6E36F7E1B6" modified="2024-01-24" version="1">MESRFIDDQFGDLVTGTLPNYSPATGWTQGATCTGCGFHPNASQAFNQTWHDTTHHTTDETRSVQFGFTGTSLDVFCIIPNPSDPNLTSTYNLTFELDGQPLGETFTHISDSTNVFQFNVSVLSLENLSLAPHIFTMMAASTIVNSTLQFDYAMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0T8</accession>
    <name>A0AA38N0T8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_995915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0T8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="514" mass="56006" checksum="182778D0663EDF84" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0X7</accession>
    <name>A0AA38N0X7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1132144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0X7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40712" checksum="CA908EEF2D627A17" modified="2024-01-24" version="1">MSVRVLTGSDVRNITTKLSSDFLQSLMGDVFALISSSEDATSYLPHRTSIPTENHTALFMPARISSIGTTMKVVSVPSRSDDTRGLPASTLVLDKHTGTVKAIVNARSLTALRNAAGSLLSTNLVGLTSPARIVAFGAGEQVLAHLDLHFRAFPSVKSCTIVNRSLNDRLSSVTAQLAIKHPSVNLSVLAYDALNVTDEEKGNLQTCLSDADIIITATPSHIPLFPSSWVRSGAHVIMIGSYTPHMKEVDTDLIMRAIPTSFHNQEAQLPILLVDSISACFAEAGELLEAGIHPSQVIEIGKLVLDERKHVQARTETRDSYYKSKDVGNDFVGPITIFKSVGVGLQDVAIACAVVDMAEEMERSNFKGSTGVVIPDFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2F2</accession>
    <name>A0AA38N2F2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1037268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2F2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="241" mass="26761" checksum="6029BD0F5EEFDF5F" modified="2024-01-24" version="1">MAALDEVMPKVARQHIIWIESDDEDEQLMVQMERLSVKQEASNCTPQTGKKCPQDQRPSSSTQWHETPPPSRAPPDPPKYSSPKPSTSQTSSTSMVPPAAQATPGRQGIFNAYVVYSGRTPYFYTDWPAVKCMLDEDKDLVFKGFFTLEHAEEAWYAASDSGVIVAIQNGTGRPIWSVTEGVKPALLKFFDRHEAVKIGLGWGGGYLKGWHNEADAIKDWNDKAQARPSCIVTTPDPAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N394</accession>
    <name>A0AA38N394_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1152443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N394"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="536"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="784" mass="84727" checksum="DC6750DF22FB24FD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3E8</accession>
    <name>A0AA38N3E8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1221696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3E8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="141"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="415" mass="46461" checksum="0D71C784B4EE9C4B" modified="2024-01-24" version="1">MPLSLRNQPFRTLYLTFDFVGTVLVRAPLWLLLSIPKSWRPRASWSIKDSFLIQLLRHFISVRSRTCLYKTESNYPIHEEKGVHCVWVDPVPKLIVGDLAIWSRAASVSSKPVRGYWYCKNTSATPNTLRMASSGEKILYSLHGGAYTSGTAHPSGTNAKLVRDIMHLDSRINRTFAIEYRLSSDASNPFPAALIDALAGYHYLVHSIGFNPLDIVIEGSASGGNLALALTRYLIDYYGHSDVPELPDVPESLILLSPWVDILANDETHIEPTIRSWLVSDYMFGPRCPMTNYSKQIFLGPHGIDVAALNEYISPSSRHPLIELDFEDFPRTFISSGAAENLLPQIRLLRDRMVRDLGYDTRGAEKSLRGKVTYHEAAEASHNCLALPFAIQQDARRGLLAAIGEWLVDCTTETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3G4</accession>
    <name>A0AA38N3G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Receptor-activated Ca2+-permeable cation channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1059522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3G4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="4">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="5">
        <location>
            <begin position="234"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="834"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="97046" checksum="A342FD8DB5F2D62B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3R2</accession>
    <name>A0AA38N3R2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ndufs8, NADH:ubiquinone oxidoreductase 23 kd subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_32112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3R2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="259" mass="29606" checksum="F1D4B7B554D5E99A" modified="2024-01-24" version="1">MSFARQTIQAGLYSRFRPASVSIGSSLTSAAIRSAVAQRRLIHSSRCTRASQHDHHHEEQHTESLHSDMKLLHGRYPETPLYADLNSNANIEKFKSGERAIDKAVHLFFLTEIMRGMWIVIENFFRPPYTIMYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIESEARMDGSRRTTKYDIDMTKCIYCGFCQEACPVDAIVETQNQEFSTETREELLYNKEKLLANGDRAEAEIAANLHADHVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3X1</accession>
    <name>A0AA38N3X1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1051942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3X1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="402" mass="45650" checksum="D593AC892E941483" modified="2024-01-24" version="1">MSTNMSTVGACSAKPFVPVMQDVPRLEEVFRHCLIVDPKTSRPLPTEKLDLLLREDATTTFQRSHEKVSLPSFREFHEASLGKFAGTTATFRWPSLKPSSNLEEPDMFRFFEKPLTSPKAGAGHSSSNCTSPAVTSTCTTPVSEAGSLKRPRSEYDFGAGDEDNRSDTSRSSGMSPGGIRIVRTRKELFDDPHPWSSNTSDHSPSFYSHLTVMSRQKPGSSRKNPPLRVNTDFTSPSMTPEAVYTFKPLRGYPVDQLEALHGACCSPHKWATFAQQDERNIFKCRWENCQYKAKKQLVKRHIETTHMRLKPFVCDFCGNKFPQRTSLNVHVASKHTHDKPYKCPYKDCDEAYNDPARLHRHKTDVHNYIPKPRECRAPQEKIDDYVRSFQRLRTAPLGPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N432</accession>
    <name>A0AA38N432_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_521081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N432"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3736725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="502" mass="54176" checksum="CD238A7082431DEF" modified="2024-01-24" version="1">MPATFSHHFDTPLYNEKATIQTGLFINGVFVDGVNHSTIDVINPSTGKTITSVSEGTAKDVDRAVEAARNAFNTSWGLKVPGATRGQFLYKLATLMEESLDEIAAIESLDNGTAFGVTKGWVVPFSIGLIRYYAGWADKISGQVIETDEGRLTYTRHEPIGVVGQIIPWNAPLLMFAMKIAPALAAGNTIVIKPSELTPLSALRVCSLVQEAGFPPGVLNVVVGYGNTVGSAISSHMDIDKIAFTGSTLTGRKVMEAASKSNLKNITLELGGKSPNIIFNDADVDQAVNWACHGIFFAQGQICFAGSRIYVQSGIYDEFLAKFTARSKMHKIGDPFGADSYQGPQISSTQTERVMGYIKSGVDQGAKVHLGGQRHGEQNGNFITPTIFTNTTPDMKIVQEEIFGPVSVVIKFEDRQDVIQQANDTIYGLAAAVFTQNISQAFEVGHALKAGTVWVNCYNEVSAAVPFGGFKQSGIGREYGSYALEHYVNVKAMHINIGHKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N453</accession>
    <name>A0AA38N453_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1050992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N453"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="451" mass="50590" checksum="08205938F80541B7" modified="2024-01-24" version="1">MSTGDPRVQQHRPRLPKSYTDQQLAFLKSHLPEFERRTQGSIRGDAKKFALEKAADFINVFGLPNEFIHVEEAEPRFKEQIYNWFKNTVGRTRRKLEGRPRSMKKALEKGGPMNNAIDSTWSTGNVLAAPIVMPYAQASVNSATGSPTQTLVSPVQYSVLRGSSIDPMLAHRQSSLNQQSPRQHHSSLELAVNLQITTSTLRDSFSQGIDASSLASMIQTFVKFNPSTTPLTPVITSLFEAITAELSFSRDPRACLRRFLDASTLFPPSIVHAGVSGPLAGPRALQMQIRKNSIWFPNPPTDSTISSPSYSMSDELQRLANDRQRKKDHIQWARIHAAALELGMLNMEHSGHTDDSGYSYAMSRAFSEMTARDAVWEEDEVEWVAGIYVLRAVIRTAMQSAQRKREEYGELLATYERRLKDIRDENRQTMVAEALMGAKEDLAQLDGVLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4G3</accession>
    <name>A0AA38N4G3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1049098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4G3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="137" mass="14983" checksum="9EC8E7976E4B99BD" modified="2024-01-24" version="1">MVKSEIDDIFASKGKIQPSPVTVTSNSSAVKSTKKDKKRKRKERDDKDSPAVEKPKKVPETIIDPSASMPSAKRVKSSKSSEKAGNGKETKSGKAKEEEKFKDSRGTGPRRKTEEGWSIYKADELGIKDDDEGGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4V1</accession>
    <name>A0AA38N4V1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine triphosphate pyrophosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1149219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4V1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="250" mass="27310" checksum="6C0F45BB77ED9FC8" modified="2024-01-24" version="1">MSRELSSQHILPHALPVPAVKKLAGKRIVLASNSPRRRDILRTIGLAPDIVPSTFEEDLSPASFVDIHEYPVSTASHKAVEVYERLVAEDPDNAPDLVIAADTVVLTHAQPSTSQTDYTLLPSIGQELLEKPKDKADNLRMLMDLNGQVCEVVTGVTVAYPILTAPGYGLHSIDERSLVYFADNPKHILQAYVDSGEGLDRAGGFAIQGMGGILVRKVEGDYQNVVGFPMASFFKLLDALVEEEEDFLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1L3</accession>
    <name>A0AA38J1L3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1106986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000113">
        <property type="protein sequence ID" value="KAJ3711871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1L3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3711871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="104" mass="11562" checksum="A927C44CE98DA595" modified="2024-01-24" version="1">MEDDFEVALYHDLHCLDVIRSVFVSMRDGSSAHSPEAEECLGTIRQAILCTADITLEPAEVICYDGEECNDAGPEASGNNVDHSCRDWVQVRKFVESNQKGWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J235</accession>
    <name>A0AA38J235_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000135">
        <property type="protein sequence ID" value="KAJ3710619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J235"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="244" mass="27135" checksum="B88974F027162EF1" modified="2024-01-24" version="1">MDYYHVNVESDLRRNTCHQSCTIYTSNPGWIFLEIEPHLRKLSSATLRLFMGSSSRTGNDLVPESEDSSQRSGSTTDMQSVTSGDPVSPPVSPSVSSPVSPPWESRTTTSENAARLSREMDTPISLVVLKPSMSDIDSRLLDQAMQNSDLVMETSFASPTMGTNFQQKDPLDGSHDTNGRSNDPGPRTWFVQRRHKFVDDVRPYIVLLHAISVSVPQLDSDGPENPELNNDRFATFWNDIANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4E5</accession>
    <name>A0AA38J4E5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1210312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4E5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="265" mass="30215" checksum="283B1A317A75EEFD" modified="2024-01-24" version="1">MGTFEEQATAIFDVLESKSDVLVSDRSTGQELYKVERVPHHGKMIFHRAGSSEPLAIFEHKSIVPDTITFAGGKNMHLSHWMHVQETALSATFEEKGHKYTWMKYDNGPFTLIAESNQKRIASFEQKRHVEMPAEGTSRTALPHIVMLSEAEEIKDAVVISALILEHDKRWTRNNDESIFIYNILRGEANIVTFIPCLVYKQMLSLYIVSPHDYLEITQRLMSSPTANETDKAAGQWNEILPETVGGQSLRYRLIELIRKPHIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J538</accession>
    <name>A0AA38J538_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1158450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J538"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="220"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="407"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="802" mass="88385" checksum="8092B972D0B2E4FB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5D8</accession>
    <name>A0AA38J5D8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1169284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000126">
        <property type="protein sequence ID" value="KAJ3711088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5D8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="226" mass="25948" checksum="5A5F0C3C3D964BD2" modified="2024-01-24" version="1" fragment="single">NLSCVRAGYYPFGSERAAYDKLLGDTQIELDRCQKEIDRLEILCNTLIASKQLLQANKRLIHSILSPIHKLPLDLLGNIFEHLCYDRNYLYGSSLPNVPTLNLSSVCHRWRSLVSSMPILWSTFNMIEKEFARPHNLLPLFLGRSHPCPIDFQLHDRNECEGSSRTSKYISSLLLHSDRWRHVEIRSQFLPVYLLQPLIKNGAQLPSLKSLTLGMGDDEIDDTDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J642</accession>
    <name>A0AA38J642_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1169255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000126">
        <property type="protein sequence ID" value="KAJ3711079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J642"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="397" mass="42105" checksum="E9FB4370939EEEA2" modified="2024-01-24" version="1">MTTVLSRSASLSSFTSAFPSAGVLSLHNSSSTIGKENNCTMNSTGEASREAQASTSQQPNQSAAVTATTASSSTARPLKEEKSEPYYHDDSRKAPGPTPEELAQFGCQNPGFRPPLIQKQPTPLSHKLWLDRLAAGNGVSNVGDGASISTAGAGLSRGLGGLVRQRVVQDLQDPEQSQQSTYSSQYSGGSQSLPPLEYITSQESEPYIETPVVTPNGSLHWKDTSHLPIDMLDLHAQISAEDLVGPKRSLSSNSDPLASPPPSTAELTLPSLHSLIPGSPRTRLASEVAVEHEPSRPLKRQRVVSPDSPSPPSRRTTPPGPVSPSQGLDNNLPSGSSTPPPLLLHQPDDTTFVNDVQPQLELNNVGPPACLGREAVFLCSLLRCKPNRERGQTGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6D9</accession>
    <name>A0AA38J6D9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_658342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6D9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="91" mass="10127" checksum="2698096727FD9B52" modified="2024-01-24" version="1">MSRSNGRPEPEVIMNFSDGYSYSKAKLDSACFAILENGPTKVSKDTKPASKKEDIDLIVNEFEISRARAERALAENDKDVVKTIHALINLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7D3</accession>
    <name>A0AA38J7D3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_503169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7D3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="711" mass="77070" checksum="FC856C68133D7470" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7P6</accession>
    <name>A0AA38J7P6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_999842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3730987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7P6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3730987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="530" mass="59735" checksum="2E703B449FE31C9E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8D7</accession>
    <name>A0AA38J8D7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_856382</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000088">
        <property type="protein sequence ID" value="KAJ3714882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8D7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="224"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3714882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="446" mass="50079" checksum="D9676025F9CE2E08" modified="2024-01-24" version="1">MGNAASGLNPPGGQGNPNDKDKKEQQKKKWEPPLPTRVGKKKRRGPSAASKLPPVYPTTRCRLRLYKQERIKDYLLLEEEFIQNQERLKPETSLEEKNEEDRSKVDDLRGSPMAVGTMEEIIDDDHAIISTASGPEFYVSIMTYVDKDLLEPGCQVLLHHKTQSIVGVLQDDADPMVSVMKLDKAPTESYADIGGLESQIQEIKESVELPLTHPELYEEMGIRPPKGVILYGVPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPKLVRELFRVAEEHAPSIIFIDEIDAVGTKRYDSTSGGEREIQRTMLELLNQLDGFDTRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDVKTKRHIFKLHTSRMNLAEDVDLEEFVMTKDDLSGADIKAVCTEAGLLALRERRMRVTKNDFTSAREKVLYRKNEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8Q6</accession>
    <name>A0AA38J8Q6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1155298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8Q6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="422" mass="48112" checksum="DC814A4F35960B3E" modified="2024-01-24" version="1">MSLRPELSDLLPTEIYEHIISFLYHPFTLKSCSLTCKAWLRPSWKALFELCTIRIHRKNIDAFLEFVELDARTLTFIRLIQHLHVEQGGSKRLPMSESQWGLQELGDYEIFQFDDFLHRFVGLTAVRTLKLGWVRCDTTELTSAALRSNFARVTALDLDSMILSSPEHFFDILGAFPLLSSLSLSGVLFNGGRLYDGLDNWEELDARRTELKSTPPPPSNLRELHANVTEDVTEFLFSWITYHDISLPMRSLACGLFSESSNAALSKFLAHSGSALEDIMIRDAHESTNLDLSPCINIHTLEIGCIHLQSSNGDQRERSSEIFVTDVLQTVTSQKVEYIKIILAISDYEDVDDQIYAFDWNGLMSILRRSQFKDVDLVEILVSGYETAVERVISEYLLDLSDNAEQRPALRAQLHVTKWARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8Q8</accession>
    <name>A0AA38J8Q8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000110">
        <property type="protein sequence ID" value="KAJ3712348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8Q8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="200" mass="22464" checksum="F62222C021F46A09" modified="2024-01-24" version="1">MSFGSDPQDFVQYALSLPDNISDDSSHESESFEPYTDSNSEIDSDASDMESNASNDASDTSEVASWDEIIRRADPRYRHRFLRHMMDYYTNPDPDVGPFDYSDSEFNYSHDSLVNSAHSSDSFHSAHSSIAESESGESSHDNGSESSTEPPDYMGPDGRLLESERERRRNLSLCFYCGEDHFCSHCPKLRAKYSGDSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8Z2</accession>
    <name>A0AA38J8Z2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8Z2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="208" mass="23142" checksum="B94C718CFB468AD4" modified="2024-01-24" version="1">MAKENAYKKRELESISAPLNCSSDSEFAAGPIKVTEREPGKKKRNAKSQRDSGRPTKKRKFGWSDSEDEKCMDSLEISANTTSRSQTYGKNANGNPLAKYFVEIDDESNDDADDEMQVGNDDDEENEDEDQDYGEEKVVHIPKTMVAVLPVARQVQKSPRCHTSDAEQSSHTEDDSSHTESDSEPPFPPIIPIVNADSSHTEDDPEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9D3</accession>
    <name>A0AA38J9D3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_997734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9D3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000009">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="131" mass="14462" checksum="7067809310DE007D" modified="2024-01-24" version="1">MTDSKDKTDEEWRAILSPEQFRVLRKKGTEPAGTGKYDSHYEEGVYECAGCGTPLYKSNTKFKSGCGWPAFFDAVPGAVNRHEDRTFGMTRIEITCAACGGHLGHVFKGEGFSTPTDERHCVNSVSLTFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9D5</accession>
    <name>A0AA38J9D5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_88548</name>
        <name evidence="6" type="ORF">DFJ43DRAFT_88708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000117">
        <property type="protein sequence ID" value="KAJ3711623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000117">
        <property type="protein sequence ID" value="KAJ3711629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9D5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3711623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3711629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="561" mass="62805" checksum="BEAF89316FAE3393" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9I6</accession>
    <name>A0AA38J9I6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1154950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9I6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="122" mass="14094" checksum="FA3A9B9CA95C4C1B" modified="2024-01-24" version="1">MSSPLPFSSLSRRPSYQCQTHKSTPRTHWNRLLKENGLYRKETEDLQRKHDKMIADGAEEWDLKNAKRLVEESNKMVIDTNDRMGRAVGELRDVVIKARTEPSFAEDEDFMSAEAILEEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAE6</accession>
    <name>A0AA38JAE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1073628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="542" mass="59656" checksum="BA8865F23B565242" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAI9</accession>
    <name>A0AA38JAI9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1224037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAI9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39535" checksum="ADD2C3E23FC25BAC" modified="2024-01-24" version="1">MGRGVSDADWSNPEDTGAVIQFFFKAENRGKLGQGGNPTKAALNECAAYLAKNQEVKKGGPKTAGAIGTRWRKIKSIFEAILAVKQKKFVGASGWNYDDETGFGVTESNIDEWNDFVRTHTIFKPFATKGWEFFDEVQEILPATTRGKYVYNASGHSSSTPDLQSQSAHSQQSQTGTPHDPLGSATNAIQTNENPSTISHPPTPTSSSGPAASTPHPSLVTTPAPSTPAPSTPAPSTSRSALMKRPASDMDEFESPWGAKRGKYTGPEAIFSLSQSVQSVGNAIRDSMPVPKKSSAMSPTKKIEMACALLREDRRNFIITWDQSMELIIIFGQSSTAAGVYMSGQDDERGDLAKLLISKHGQSLFPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAQ8</accession>
    <name>A0AA38JAQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1154051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAQ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="216"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="363" mass="40989" checksum="7505D2C8425D52D0" modified="2024-01-24" version="1">MSSIIITRTTPTATAPYYSCGYSSNSSHNSTSSVVTQSGAKGYRIEVEERRRRTVFVKSNVPPEQWETHQILDIADIEEGDEQGLEGESKVHRSKSLSERPRVIGAMVVDSKRSRSGQDLPSNQHAQPRYSPGSDPSSQSSSRYQSRRASLKPSDALTSATAAFNRMSATPNTPPNSPAVWKSHNSVTRNNLSSETHRSRPMTMEVAVPPRPRILFYHKHNPHYGFTNFSRHSVDYMGKRYPTSEHLFQSFKACAEGPRHRLLIAEHIRTCSERPSIAFSEARKFQSEVRPDWKKINVEKMDVTLYHKFTQHPDLMNELLATGNAELVEDSDKDAFWGIGADGRGRNELGKALERLREQFRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBC4</accession>
    <name>A0AA38JBC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1159847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBC4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3717312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="246" mass="28052" checksum="968FB06C9115F5B4" modified="2024-01-24" version="1">MRSNNSVVYLPLNGNDSEDIIVTKTRHRGSLCRFLAPCLLVISVSLNVVFMTSKFLGLKAPTSQALYSPAQNVVEYKTVKFHSGFGADLPIYDRPPSPEVDAAWDVALNKVPRNEAILMPNRTYPILGEEDHYMIALDVFHQLHCLNEMRKAMYPEYYPITGEGIHTPHMQHCISSLRQSITCSADITPIVWQWSNKSQAAKERSDVVHTCRNFEKIKDWAEDRFVPRQQNMSVFIGDDLNIPTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBG1</accession>
    <name>A0AA38JBG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1089054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBG1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="563" mass="64602" checksum="AF6B4BB9889505C8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBH8</accession>
    <name>A0AA38JBH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1067533</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="247"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="353"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="650"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="906"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1349"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1371"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3733522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1390" mass="158277" checksum="111249B388BDFC9B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCF5</accession>
    <name>A0AA38JCF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1096134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCF5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF6">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="100896" checksum="4A487E0668C646C7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCL9</accession>
    <name>A0AA38JCL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1109486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000158">
        <property type="protein sequence ID" value="KAJ3709750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCL9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3709750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="375" mass="41791" checksum="CE52A0464F1A3DC2" modified="2024-01-24" version="1">MALGISEAQLLGLFLASVFWGMFLITFIQCIRYLLWDSRGVLKPAATVNWPLFVVAALLAFLSTFDVALGLMHNIEAFIFYTGPAWGSAARFTGLTDWVNILKTCNVVFGKLISDGVLVYRCWVVYNKRWLVVAFPLLLWLGYLGLAIFVVYVEASADNPHVLLTGPGLSDLTPSITSGWTLSLVNNIIATGLIVYRIWRVDKESSMYAMQSNSSRSRAFFSRSSQRTKLQNVTRVIIESGFLYTTIALITFITFLTGSNSFYAASDAELQILSIAFNLIIIRISTRPEENHSVQTSKPNHHPSFPLRTFTSVMDSTSPAPDELTSKRTLEVMVTNEESVDVDYPPARSRGRDSYRSAIDNKSRMDVDGNLDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCN2</accession>
    <name>A0AA38JCN2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1084916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCN2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="59"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3728139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="501" mass="54413" checksum="39106AA368ACFE44" modified="2024-01-24" version="1">MRDKNELQEEDANQQATAISPEQDPTLLEKKWPTTDFGLIPIPERLQYHPNKPPFHFGLLLNASFGFASTFVVANLYYCQPLLIQLSQSFNVSYDEISKVPTLVQAGYAAGLLLISPLGDLVRRRQLILLIVLLSTTLSIPLAVTSSLTIFLTFSFLVGFVSVTPQVLLPLAADLAPAHKRASALSVVFAGLLFGVLIARVFAGIIAQFTSWRVVYFLAIGLQAVVLLGSWALLPDYPAKNQGTGMTYQKILWTMGKYAVTEPVLIQACLVNMGSSASFSAFWVTLTFLLGGDPYNYSTLVIGLFGLVGMFGVAMGPFVGKAIDALPAYHASLVACIALIIFQVVQVIGNGISIAAVIIAVLGLDIFRQMLQTSLASNIFSIAPEARARLNAVYILSLFIGQVTGTSAGTYVFIHYGWRACALMTLGFAVWQIVLLLARGPGLDRSDSVRGKRWIGWNGTGLERSRKTQKLSDVEEKDGRSGNQTPQVEGVDTKTHSNSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCZ0</accession>
    <name>A0AA38JCZ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1042426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCZ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="265" mass="30592" checksum="58F3684CA9CC7E92" modified="2024-01-24" version="1">MRDTYARPVLKYLRNSEGAASVFAWPKDIGEMREDEVFARGLHNDLNHPHFGFEKDPIQRRFGDPLAERLEHCLIQSAPFSGELSSNEPVGSIERFVAYRISDHTHLLLDSAYEDLECQISTSLLTNPDFDPSAWYARKLNVQGIPTATGGTTPRRMGDARGTRVSQILNRASRYPGDDLPDFHPRRNNYRGQRFHAFLSGFRGDVYIVEDALYGIRWPLHTALLDEPRFDVYRWCCKQLVKLLRECLKWDLWEARSVFGRSFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDN3</accession>
    <name>A0AA38JDN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">malate synthase</fullName>
            <ecNumber evidence="2">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1081904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDN3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="8">
        <location>
            <begin position="157"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="10">
        <location>
            <begin position="407"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3730909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="540" mass="60956" checksum="F39960B25FB5B53F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JED3</accession>
    <name>A0AA38JED3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1134616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000079">
        <property type="protein sequence ID" value="KAJ3716263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JED3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="21"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3716263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="468" mass="51163" checksum="B98093F04CF4C76C" modified="2024-01-24" version="1">MGSIVASTRTGLFQNVRVYWLAFIAYWGILLFGYDTGGVVGNLYFEEIFGIANSTGSINTKKSDMVSSNVVSVLQAGAFFGALLSAPISAKFGRKWPLFIYTLTFAIGAILTIIPSGNNPRRGLSEIYAGRVISGFGIGAITAVSPAFVSECSPKEVRGRITGLFQVMVASGIGVGLHVHRDSRIWRIPFGLQLVPAGLMALGLLTVKESPRYLASVGRNDEAINNLAYLRRSSAQSEPVILEMAEIEAAIQEEREARRSSDGGKRVVKVVTVSIFIAFGVEKFGRKRFLFISSMGMGILFFIIGALLKTYPPPATSANDTSPSPSRASQAMAAMLYLEGVCYVIGWGPLPWIYVSEIFPTRTRHYGLSFASASQWLWNFVISKQTPIMKTELGYKLFLMFASLNIGALTIFALLIPETKGKSLEEMDIFGAVDAKQRQEHIIANTLVRNQQPHEKSPRESISLDNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEQ6</accession>
    <name>A0AA38JEQ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEQ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="18208" checksum="66DE3280339215AF" modified="2024-01-24" version="1">MYNPVFTESSVFVCDGTDPTSDLFCQDATMGIVFVAIVTVFLLGVVVIIMALIEGVCFIAAQAYTYLAKYNLCDKENALKRREQAVVLRELAVNRQERTLQMDVEIKVCERLTQILRRSSASAQERAYELEIEKDLLSEIAGCGGDTSGEGSLIHRIPKSPIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF08</accession>
    <name>A0AA38JF08_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1002697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF08"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3725083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="295" mass="31672" checksum="198DB980C39715EE" modified="2024-01-24" version="1">MITLNSDNVLNPTEPEGNFSALIQSFAMIIVSEVGDKTFLIAAILAMSNPRLVVFAGAFGSLVAMSILSSAMGHILPTLLPRRWTQLAAGILFLVFGTKMFVEGRQMKAGNEKIQEEMKEAEEEIEEDEARHEGLQPPALENGGHLVPLGVIEGGRSPVFASKDSTLRPKSKPKRSFVEGARNFCSFFLGPVFVKAFALTFLGEWGDRSQIATIALGAAHNAYLVALGTIIGHGCCTAAAVVGGKYVSTKISAKHITLGGAVLFLLFGVLYLYQVFMDTTADDVSIPIINHPEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFV4</accession>
    <name>A0AA38JFV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1086869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFV4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="364" mass="41178" checksum="77E947DA0B6664BA" modified="2024-01-24" version="1">MDEKVEPMPTPGIFTRKARSYPGDEHSARETISQGHAEGSIIGFYALIDIHRSIALRRILERESGVSTVTVAEGIIEAEFSLPPWAKRSIFMDGHGVSSKENAYDWPTIRVPSVEQPHLTKSSDRHYAYWVAVHGTIIDHPGIFITNSGFIDLDTVAGHRLLRALDFAHSSESSNFKELFITLLTLPKFYSQLVEVHHLNIAPTIQPMTCPYEPKTIIDVACHMANCGITESQADSLLQYARFFCIDKLQSKLRSEDELGPWLKILRRSNLRMLVTDCVPERDPTLELPAHWNRDDLKEYRRRRAVIHGQKSRGQLPLNWHMRHEAIPMNPKTGNPVEEMANLSLFETNPVVSTSNGVQNPATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFV6</accession>
    <name>A0AA38JFV6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_150643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFV6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="149" mass="14817" checksum="CBD381E9B1B2488C" modified="2024-01-24" version="1">MLTDLAGAVECVQSSDTSLASSMRSATKDFIQQCQQAGVNGLSDPLLTSSSIVFSTRPSSSVFPTASVSKSAVSTISSTISSPSPSSSPKPVSASFAPSVSSSSTSIPPPSATSQSSSALKSILLGPSSSMMGAIGITLTTTLAALICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG20</accession>
    <name>A0AA38JG20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_483976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="316" mass="34741" checksum="2B1E678A0DB3D513" modified="2024-01-24" version="1">MSNVANLTDAQLNALSECITHARIGQSITYASVVLFLYDYSLTVWNEAKYVWRPGRITITSITFIIARYAAMASAIIALLPNASVPAIDSTATVFRLVAIIASELILAVRTWAIWGRSRKILITLISFSLAAAIPAATIVAESVVSNHVVPLVNEEFKGICSLTISNISEGFIGPYVVAMLYEFVTLTLSLIRIIRWRKTIPEHVRAPILDTLWRDGVLYYSFMLVLGFVNIGLVLQQGVPQVRTGGAELQAVLHSILSTRIVLHLASSNDSRDITAPGCSVYRTGIQFTSEFATIDNSGLTASRFNRDAIYEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG90</accession>
    <name>A0AA38JG90_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_543143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG90"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="228" mass="26428" checksum="F5F91AA6620AC83F" modified="2024-01-24" version="1">MELVYMQTRIAVPRMKRVLQYHHAEGDSLIVMDFIPNSRRLGIAWPTLSMWSRLKIILTMRLYLRQIRRVQHTLSSNVPGPISSTPLPCSGLQLSLDPLGPFPTVAALEAHYRKQIADAEYYASRGWSRSPKCKPLPTSVFTPLVFTHNDLNMRNLLLDDRGVLWIVDWGFAGFFPPWFEYLGMLYAAQKDDNPESWQHCIKYMAEPNFEVEEWMQKMGYGFHHPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGI3</accession>
    <name>A0AA38JGI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1037704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGI3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041222349" description="Lectin" evidence="1">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34152" checksum="5B3869718A2809C0" modified="2024-01-24" version="1">MILDSKFLLGALAFFSGLSSNIDPVNAQTGVDTIPPLDLTTPLWIWTGEPPNIPGMRAFRKTLPQGRSRAVCVTFGIAADDSYTVWVNGVEIGDNIRKGGDPAGSAFRELDIYSVSLSHIKNVIAVNATNIINVDGVILTGVVKYEDGSQTAFVTDASWLTAGAATPPDRFQEIEFDDSKWAHAAVIGPVGTLPWGALHFAAFTGKVCGQSDQPHSPHHPHIPDIICPALLPLPEGQVSPYWDLRHQVDCEIRRLEEALFLCRREKQKLFDRLIIIIKEISSFGGGDICQLANCGNEIHHHLESSTEVPIPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGI7</accession>
    <name>A0AA38JGI7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1155993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="137" mass="14172" checksum="45E2EF2638BF3112" modified="2024-01-24" version="1">MSVALPAGLYNIQVTSSNPALNLAAPSSAGGNITVNTSSSQVWQVSGDGVLTAFTTFAGQARTNNSPAAQGTNVVANSGSPAQWIITGVKLISNSYWTGYIMANDGTQLFWNLDGNNNVLVNPSSSKAQFTFTPVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH04</accession>
    <name>A0AA38JH04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1683" mass="188184" checksum="626862429D9BBB49" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH69</accession>
    <name>A0AA38JH69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1072077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="646" mass="72945" checksum="2CD091F2A89019A9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHQ8</accession>
    <name>A0AA38JHQ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1146230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHQ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="191" mass="21751" checksum="8A396C28083EAF16" modified="2024-01-24" version="1">MALQARKQLWDQGHDEKVEVNQRALIDKVLARYSGEFTVFREFYKTRMTLSPMKDNVQEEDWNRLKKIAEGNPDEEKIGAFGTEEPFVTSGAEWMGFHWRENQYVRYSSSDTPIPVAFDFVRFLASSITFMNYLSTVSTAKLTKSAGIPKELGLPRTLNVSNKSKMMTLNKLNPLWVCPSLGSVVVDSVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHT0</accession>
    <name>A0AA38JHT0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1049467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHT0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="50"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="372" mass="39529" checksum="AEEC8B798B4BBD38" modified="2024-01-24" version="1">MAAPSMAAALAASLPAPSAAPTPVAPTYEAIPPSMSTLIDVEAEISLECVQLDGLVVSKILKHACDSSSSSPIGLLLGIDLDGVLEVSNSFALPYHSGDDDDKSAKSVARYQASMLRSLKEVQGDDSIVGFYQASTLGAFFNQNLIDLQAIHQDKLRHGGVVVVHDVSQTARGNASFRAFRLTSAFQDAYKKSNFSTASLASHQLTFSSILEELPLKIHTNPLLSAFLGEFSSPSRNALGSSSASAIPPSFSVLDLNSGGLTKNLEHIVDALDNYRNEEGNLAYLSRQIARERAKADNYVAKRKEESAARVAQGLAPLPEEDVTRLFKIPPEPSRLESMLQLGQVDAYAKSLAETTSTGLVKMYAATAGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI28</accession>
    <name>A0AA38JI28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1155877</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI28"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3731045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="378" mass="42983" checksum="335406B21681333C" modified="2024-01-24" version="1">MLQHSLLVGVAPQITRRVGYNALMLSSVRLSASRSFSSCARRYNHLNDRQATAAAVGPHKNDTSSPSLAVAATNHGGDVSHQNPAHHGDWVLFHPVYTPEELKAVEVLHREATCFSDKLAANLVKISRWGYDLVSGYKHKVIPPGADMTLQQLRKEGYVLDEKQWLERILFLESIAGVPGMVAATLRHLQSLRLMRRDNGWIHTCLEEAENERMHLMTFMTLRNPSIFFRAMILGAQGVFYNMFFLSYLISPRACHRFVGYLEEEAVLTYTKCIKEVEAGRVPEWSDMPAPQIAIDYWRLEPSAKLLDVIYAVRSDETTHRFVNHSLANLDVKTDVNPFALQEPDMHIKGKKIAFERPEAEQYFKETRHILQKISAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIH6</accession>
    <name>A0AA38JIH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1071763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIH6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="285"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3732867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="504" mass="55558" checksum="0E50620289CAE1BB" modified="2024-01-24" version="1">MHSSSSTSNSEADTALLDILTGPDRPTAKTVLPRRDAALDPLLIAAASASGPHVTRNHYQHDFFPGVMLPKSEGSWDWTKFVGEDASTRSERKRLAYVSMQAPRRQRLGLDDTQGGKENTAPLSPTENLPTSHQKKRRSSLAQVTEERLRNQVSTQPESTRPAHKSLQPLEVKCMARTRIPTPHGPVFLHIYHNNRDSKEHMAIVVDPAQFSGPPAPDAPPHIRSRTLDAVWSEDETEMDRITRGAYVGRLSPTSPVSSRPREDFESLNSRNHSHPAQQVTGLSDAIPSPLIRVHSECFTGETVGSMRCDCGEQLDEAIRLISQPMSIPSQSPLSPFKQIPGRGAVVYLRQEGRGIGLLSKIRAYNLQDLGHDTVTANLMLGHQADERGYEIACAILRDLGLGNPDGVGESVRVLTNNPDKVEALEKEGIKVVERVSMIPRSWKTRNPQLVDHVVSVPVDHTRIAGSTMIGGGAVHGEDLDKYLRTKVLKMGHILPLWLDNPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIQ3</accession>
    <name>A0AA38JIQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1076571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="128" mass="13995" checksum="CB343C2A4B9443A5" modified="2024-01-24" version="1">MPEVVFTPEANPVLPVFSQAVISKGTIYVSGNIGCDKNMKIVGDIKAQTRAALENIAIVLKASGSDLNYIVKANIYLTNMARDFKPMNEVYAEFFDKDRMPARTCIGVAALPMGADFEMECTAEIPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ27</accession>
    <name>A0AA38JJ27_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pleiotropic drug resistance ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1045819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1209"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1289"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1439"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="148"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="844"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3737692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1479" mass="164665" checksum="791577845A381CF3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ53</accession>
    <name>A0AA38JJ53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_964509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ53"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="113" mass="13245" checksum="A216B48FF6D9266D" modified="2024-01-24" version="1" fragment="single">DRFDFIPDPTQVNISHDPEQDIGFSARRPTHCSLVDDDSPECTWHWHPTARNVLRTEPTVHDCWKSLFVGKHLEAAKSYKPFNSRLEWEMAQWTVKEKVSQKAFDQLLKIPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJF2</accession>
    <name>A0AA38JJF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1154628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJF2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_uL3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="318" mass="34711" checksum="6AF8ECC3A5A1EE57" modified="2024-01-24" version="1">MLRLWALKHKTSLISKYLHNSSSLTAPTTATSSALASPNAPLTTKWTPESIRTGLIARKRGMTVLWNDQGARVPVTVLQLENCQVTANIVTIRQDKSEYHAVQVAASDKPLKRTTRQMQGHFRKAKVNPKRILKEFSITPDAHVPVGTTFSAIHFVPGQYVDVIAKSIGKGFQGGMKRWNFKGLRASHGVSISHRSAGATGAHQDPGRIWPGKKMAARMGGQRITTQNLAVVRVDTSLNLIYLRGAVPGVDDAQVMVRDAKKLTAVGCHNQAKGLYEKVLPKGVDDLPFPAGTLEMAKTLPSIVEAPAYRRSPFVPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJW7</accession>
    <name>A0AA38JJW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJW7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="181" mass="20288" checksum="E10D382E531D995F" modified="2024-01-24" version="1">MYLCGLDIRAGLSFRVCAVLFLGLVCAAFTAALPLSDNDLSNPTSSVHLAARNELKKIPMRLQFIKPEDKLLRHYWIRFCTDISVEDAEGEPWKYVPKKSVSFDLELKDSTEESEEIRNKWGTWNMGTVQISSVFLPESAIIQRGTVEGAPPLMILRENKLGIRGKLPVTLDPVSVQPDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK31</accession>
    <name>A0AA38JK31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1051039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK31"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="380"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="551"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3736824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="705" mass="77944" checksum="D3F40834C60877A8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK73</accession>
    <name>A0AA38JK73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1074255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000157">
        <property type="entry name" value="Alpha-1,3-glucan synthase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000162">
        <property type="entry name" value="Cell wall alpha-1,3-glucan synthase mok12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1916"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1950"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1974"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2006"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2077"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2158"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2230"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2257"/>
            <end position="2276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2311"/>
            <end position="2330"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="68"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1636"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1688"/>
            <end position="1702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3732205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2338" mass="261872" checksum="3932AFF949C119A7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL93</accession>
    <name>A0AA38JL93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_964184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL93"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11348" checksum="96514B8228FEB4C5" modified="2024-01-24" version="1" fragment="single">YRVHDGPSFHKVHLASLATKRTLNLLEFHTLVGHLNFDTCINISKNKLVDDLPDVEIPTVRPFCDVCAKAKATRHPFPKESMTEYRNYGDKVVSDLWGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLZ2</accession>
    <name>A0AA38JLZ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps5 C terminal like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_996487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLZ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="90"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="695" mass="75945" checksum="69D26A285D350656" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM43</accession>
    <name>A0AA38JM43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1037402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM43"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="447" mass="46260" checksum="C40A2577EBF557E7" modified="2024-01-24" version="1">MNHLLEHKARSAELHRRKAYLNRADILDPLDGTTTSTSVKSTSAAATSVTTTSAAATSTTSKAADSTTTSQSATSTANTTSATTSVTTSSSKSSSATTSSSSTSSSSTTTSKGTSTGSSTSGTSTQAATTSAANVPVASRTVATYVTYTPSSSVTGTAAVASSSTTTTSGGVSAGSIVGGIFGTIGGILVVAVIVAFIVRRIRNRRRDDEHFNAAQFRNSAVLIDDEFGNDNFSARPPTMIARHMANAPAAPPVTYGNYPGADPYAPGDPFTPIEQFHPSGQYGHYNAYPTYTQEPVYTLQPGETFVHNNPIAPSGSAGSAGEMDPTTAHNTYLNRQPTLRGPDTQYTDVHQQQYLNMNRVASPPTMAASADYNTGIPSPTSATPLYHSSAEHSSVLPLQNLHAPIEYPSVGAPAPAAAATAPAAHRQDAQRRPETVYDPEDAYGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMG9</accession>
    <name>A0AA38JMG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1145279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMG9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="191"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="274" mass="29453" checksum="D90B29825E283B1B" modified="2024-01-24" version="1">MGPSSGGNANVNVNVCADVLRIGAAIERRLYERVRTVADVNVGGDDGAVAGLMLPVCSRSSQRHKHQVSLATLNPILFRDHATASLGKKFFLLFPGLGYAAGYKVAQRVYKFLTGIGEVVLLPLDALKIKRQVNLDAFRGRGIIRIIAEEKSALYRGWGWTMARNAPGNFALFGASAVTKDYVLGVTDYSKATWTQNFIASIAGAVTPITVAAPLDTVKTRIQNANFESKVNGAVVIKDLIKNEGITAFFKGLTPKIIVVGPNCSLIPLFGQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMH6</accession>
    <name>A0AA38JMH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_994552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMH6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000045">
        <property type="entry name" value="RhoGAP domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="493"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="686"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3733768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="99522" checksum="49C77985182BDBC2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN42</accession>
    <name>A0AA38JN42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_869541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN42"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="231" mass="26617" checksum="C32F420CFB075A3F" modified="2024-01-24" version="1">MFYLHGPPLNQNSAAQKAILQNVPKPSKWNGESDYMRFDEWILGLIQWMNIADQCGPPTRFSQTRSAHILTSVDLIRTNTLGSYLEGNALRWFRDEVQKVPDGFSTSRNPDPLSYRWTFMQVVNGLYQRFIHEASISQVADKFNEVIYNRKDGAKVMFSELKRWAVCMPIPPDLYTFKRRILLLVPPAMCRDMTRIEKVSAERSSINQIMQAAISCERGDCTGSIMQMRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN85</accession>
    <name>A0AA38JN85_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN85"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="214" mass="24775" checksum="B5380CB274B109FA" modified="2024-01-24" version="1">MERIEAEEKAAREAEEERKAEEQRVAEEKRKAEEERIAEEQRMEEEKQREEERRVEEERVAREKQRLEERRIAEEKRRVEEAAAEAEDERVRSAAYAKLVEENRVEREKAAKELERRQKNPVAKAQLVTVVIPPRPSGSKKKTFKSKSVISDESGDEEKELPLAPRGEKRKRPIRMIAKGGSPDDEFEPEQSGSNPPPPSNDPSQNRPACSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNR8</accession>
    <name>A0AA38JNR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_994543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNR8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="405" mass="44722" checksum="83795D5504419E12" modified="2024-01-24" version="1">MVSSHPAWLLARSERPQTQTNLNKPNEKDAEIVINADASPSQNGHSDEKRVEVTYPEGGLQAWTTVFAIWLIQFSTFGYTNAYGVFNDYYVRIYMEGKYSSSTVSWIGSMQLWLVMSSGIISGRLYDLGYFYHLLIGGSIIFVFSLFMLSLAHPGEFYQIFLAQGVGAGLGIGLIYVPGIAVVSQYFYRRRTLAMAVVASGSGVGAALQSIMLNKLFQRLGFHTTVRISAAFNAGLLCIGILRSRTRLSPTPPKDSNLLRHMKVFFREPQYVAVVLGTFFNLMGLFFPTFFLQLNANQKRIMSESLAFYLLPVMNASTVIGRVIIPMMVPVLGIFNIVTPSVFICVILIFCELAVTSAGGYFVVAVLYGVFWGAYVGMFAPMVGSLAKTDSEIGARMGICFTFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPA1</accession>
    <name>A0AA38JPA1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1067693</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPA1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="445"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="686"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="15">
        <location>
            <begin position="815"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="997"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1000"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3733555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1074" mass="117894" checksum="954D32100D57BD75" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRS2</accession>
    <name>A0AA38JRS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1171538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRS2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35160" checksum="80184BF75787AF4D" modified="2024-01-24" version="1">MSIDLESTVLERITPDEKPLISSEVNEIPPCEAGESCNLPTDIVLRSSDGIRFGAHSKNLEIYSDGFPIADSVARSTEDIILPEDSDVVLLLLRFMHHQPQPDLSLLASRLLIKFANAVEKYGVYSATGVYDQPFEVFLYAQRHGYSSIMDKAGKLAITQEPANFFAYAHSIGDTTWRDLAELETHNLPTKEVWEALRQYPDWPPIFGAWYLKREQMREAIFDALKNPSPVLHKGGLMHCADCQYPFLADVLGKMGTSIPSYKTFVQVIESCLPRLNGCTHCNIVVNNLIKSRMYTLDVIARKSLASYLDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRU8</accession>
    <name>A0AA38JRU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1045125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRU8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="263" mass="28718" checksum="B53859088A6A2864" modified="2024-01-24" version="1">MFRSAICRLPPRGKIFSLGSVTSSLSWPIYHSFTNKRTFSVIQQTRNTSASPTQNSNDSRNGFVDSTDPNLIYNAPLTSTFRRLKIFSLASLSLSCSLAPLIFVIESQLPFFARSCLAGLAVGTSGVSTGLIAWVGRPYVTTLRRLEPENGGAMGLEFTTANWRLQTRITRVYDTSFLTTTDRPFAKWQLANELELPSLSSSSKATPAATQNLEETVAETFDADGNVLGSWVVTWVSPQSKSEEGVKAGHVLGKCRSVGHIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS17</accession>
    <name>A0AA38JS17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plectin/S10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1059844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS17"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3734965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="149" mass="17053" checksum="A56637EAC546BB7C" modified="2024-01-24" version="1">MIIPKDNRRTIYENLFKEGVMVAKKDFNAPKHEELEVPNLQVIKALQSLTSKGLVKTQFSWQYYYYTLTPEGVEYLREWLHLPNEIVPATHKKAARPPRPAGVRQGGEGAYRPPRTDRGDRGEYRKKDEGAPSEFRPQFGVGRGGPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSC6</accession>
    <name>A0AA38JSC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1053344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSC6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="18"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3736093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="574" mass="62320" checksum="230D740F543C77F7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTH7</accession>
    <name>A0AA38JTH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1129075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTH7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="176"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="13">
        <location>
            <begin position="336"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="14">
        <location>
            <begin position="490"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3736918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="607" mass="69095" checksum="C688D486AC8C7553" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTM3</accession>
    <name>A0AA38JTM3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis protein SPO22/ZIP4 like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1207997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTM3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="951" mass="105779" checksum="2D12AC4D839E8261" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTV9</accession>
    <name>A0AA38JTV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1036451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTV9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041300543" evidence="2">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="172" mass="19027" checksum="64C1BEC232B1A7ED" modified="2024-01-24" version="1">MRFYTVIIVSSFLATALAAPYAQPNQRIGTPLERRGPGGASKSSGQSLTNTNLAEITFPESDVGKNMLHDSEGPNWELEYFDYSLKRYKGEEGLVLREFGKDRLKDFQQEVGRVKAAGRYVASGIHYDAESTLLKALRPYTYVIILKPSSKVGVSFLDDPSDEDSPRKASNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUF1</accession>
    <name>A0AA38JUF1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_276921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUF1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="246" mass="27116" checksum="E74A7C643CFF0EC6" modified="2024-01-24" version="1">MNPSMNTATTEQLRASTPPPPTSVQSPETPARSKTALSSTFRTDPKLQNKRNELVSGLPKMIGEMSVGEYFEHVLPPLPSGLEHRVGEVCHILNENGTYNTSAHRWTQFPQDPGAQSSHETQVFLPLANIFDAIVQAAQRLEPDLEPNFRLVVEGNATPFSEPGGDSRPDGFLKIRDKAVSQMAKNCEVLMKKEGWQDVPKPLEASHGTTNETRESPQPPTNTGQNPKRLPPPPIYGIALPRNSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUQ4</accession>
    <name>A0AA38JUQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1019508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUQ4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="352" mass="38596" checksum="8A220A661AC1A12B" modified="2024-01-24" version="1">MECILYGVYLVSLGYCLRALLLEPFEQGLQRKKHINWVMLMVALLLLVATRPCPTLFATLNVAFGLRHNLDAFSYYHGPGGATEELNDISYWVNVMKTADYVAQTFIGDGMLIYRCYIVYGKNWKIIIPSIFFWLGGSVCGVFLTYTFVTLKSPALIDNSKAVPYVDTMAALSLTMNTLTTALIVGKIWSVDRQNATLMSNTTANATHTLHRVMRIIIESAALYTISTLIFVITYVAGSNSNYGTSDNVVQIIGISFNLIIIRVDAGKSYNGRKAESISSLLFQQQPRSREQSSPLSLPSTTTDSALNGNLDSEFTGRKGITLDADVVHGCDDLERGNNANGVGALKPPSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JV87</accession>
    <name>A0AA38JV87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_989204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JV87"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="85" mass="9379" checksum="05468EEEC4465F99" modified="2024-01-24" version="1" fragment="single">EKCLIDFVELIGNHSGENMAKTVWSMLEQYGLIISFVMDNATNNDTMKTSIGTRCSAQGIAFDAQKAWGRCLPHSIHLAAVKVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXI6</accession>
    <name>A0AA38JXI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_249693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXI6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="121" mass="13563" checksum="69924300A98D3BA8" modified="2024-01-24" version="1">MIPDIPPNCPPARPNLKAFRPPKSQSKIAYFIWRLHMWIEGTFSLAMLEPWEKLLLLVIFLTTFTLLVTGIVRYLPHHISVMKGRAVYYLWGSESGESPVLQWLGKNAGSGGKSGIALGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXX5</accession>
    <name>A0AA38JXX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_987364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXX5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="59" mass="7436" checksum="38363760A13CDB62" modified="2024-01-24" version="1">MPNFDIRKELQIRYQVDRRHIYDYFHSRGRLFFNYFLHPTRMFPTRSSCRERGSSQQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZ14</accession>
    <name>A0AA38JZ14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_18927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZ14"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="264" mass="27643" checksum="1292E3B3A4BB14F9" modified="2024-01-24" version="1">MTLAQRLYASAFVTPNSSSTPTPPSSTPTPPSSSASTSSSTSSPRPPLPTPPTPSLPSHPSIISSAAVSAEAYHHNLNLNHNLNPNSNLNPNSNSNLNSKFSLDNSSTITLGNKLGTGTGNRLGTGTGLGIRTGTDTRRHSESESFYKTGVLQSLQQQQQRQRPQQQQQQQFRPQAQAHIGTGTGIGTGTGTGIGTGIGTGSYRIPNTLVRPQAQKIHRIDRISRINEINEIGYGGSTTTTTTGGYSTSGSLTGVIRPVVSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K0H8</accession>
    <name>A0AA38K0H8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_627077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K0H8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="123" mass="13612" checksum="D9ED327A333A2DD4" modified="2024-01-24" version="1">MSTQPLLQRTAAKRIALPVRVEPKVSFANERTFLSWLHFTVVLGGLAVGLLNFGDKVGKISAAMFSVVAMAIMIYALYTYHWRAASIRRGGRGPYDDRLGPTLLCIALLVAIIVNFILRFTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQG5</accession>
    <name>A0AA38MQG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1009040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000124">
        <property type="protein sequence ID" value="KAJ3711113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQG5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="121" mass="13133" checksum="477537629ED51535" modified="2024-01-24" version="1">MSSTTVNALTDSLPNNVPTLNSAGKNWAIFELRFISAVQGKGKWGHFDGSTTRPVLTSPTVSLISDMGDWFKDEASARNMLLSKVPDSIALKLCKHLTVEAAWAALNTEFTEKSGYAQTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSK2</accession>
    <name>A0AA38MSK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peroxidase, family 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_547640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSK2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041461504" evidence="8">
        <location>
            <begin position="20"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3727380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="293" mass="32753" checksum="E34A9AE8BD3FB0E3" modified="2024-01-24" version="1">MRIIIFSLTNLVLTLPSWSAQIVFDTEAIQHQSPQFDNIDWNHHRWIVPSKSDLRSPCPGMNTLANHGFISRDGRNITIPMVLEAANVVYNSPVNPVLNLALKLALLTTDAPDSFMLDDLKLHGTLEHDASISRSDHSLGDNLHFNSTIFSTLSESSLDPDVYDTTSVGQVLEERLALAKKVNPKLVNTVKERQSQLLEASLFLSAMGDPTTGVAPKKFVHIFFREERLPLAEGWKRSPHPMNGTSLMNLMAQLDKASQTKGPWLPSSLLTCPWTRLQPEGPEMVWPPKLFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU35</accession>
    <name>A0AA38MU35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1161596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000113">
        <property type="protein sequence ID" value="KAJ3711880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU35"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="198" mass="22424" checksum="22246B111B63E6A8" modified="2024-01-24" version="1">MAPLFQTIKSFNDVQISPEGVDTVDFLEATEGVVTMFDLFGSKIFGFIQSDIRGNIGGVRTRYQTYQDSSRTLEELVKSEGIHGDHRHGTACMVRLVRGLALIHHALKRMQEHPSDELHVCFKSAYDVVLKQHHAWVVRSVVTVAIRAVPHRRDFYHVISCGEPSDKFDPELNKWLQALEVIVGRMKDFLETGGYGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUK9</accession>
    <name>A0AA38MUK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1223513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUK9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="509"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3733244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="939" mass="98396" checksum="A5AFDB632C2CC2E7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV58</accession>
    <name>A0AA38MV58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_845887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV58"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="499" mass="54347" checksum="05B8B573054208C0" modified="2024-01-24" version="1">MEVQEPYPRAQSAMQMRSSGFHSKANSIFNKVSILKVRLLGNTRSKNNDNHNASKGPYMSMNVAATSTRETRSMDINMHVAQKPYMSQPVLNIRSMLDPEDHDGGDSTGSSSQSMHHPSPPRINFVKPTVSQQQHGAVEGLPHVNEDAKMNRTYQARLEGFPESSPFKPSRQVQAHGQKDKVPSSLHTDKLHQDQVPDSSSYERPRRDPERPNMSGSTLSISSSATVTPRKTHSSENSLGPIPPPKPELLKNAPSPQTLSSSPSPTYTSPLNSQYQLNLNASPSSQRLTTSHNPPPTTMPPTSSSYSSRRPSAPHLNTALPTTPSSRRPFAPHLNSPLPGRRFSLVTSDNESASARLSPSIIIRQPALPILNLPKLKLPQPVTDEADGRSPLARNFASEGPGLAGSSTFPRRMTGVIGSIGSPVVESKRFSVHAQSRRNLREMPALPMAGNDHHEDDDDHDDIDGDGESSDEDEDTDAEGEGEGEGDGEDEDTRSSIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW58</accession>
    <name>A0AA38MW58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_755389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW58"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211:SF14">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041329264" evidence="1">
        <location>
            <begin position="18"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="371" mass="41565" checksum="A424A51C8041E6C3" modified="2024-01-24" version="1">MISGFSLILLVLPVVLGTPGQYPLQRVFSKYFDVQAHRGGRGNTVENILPAFAWALIDGATTLELDNAVTKDGEVVVWHDENVVATKCQDTGPAFANDTEFPYIGKYIANLTLAQLQTLDCGSKRQINFPLQSTYSGVRISTLKELFSFTECADPEYRILWNIESKVNAEHTNRTRSPRDFVESQHDIFIHSPYRHSITYQSFDWRTLVAMKALDRSIPTSALIDLETAVMPDNKTSPWLAGVRLDNFPGDIGNQIANAAHAINADILSPADVASVVADPTLPEYIPFTTRSMVDGAHRLGMLVKPWTVNRLSIAEQLLDWNVDGIITDYPNMMRRLVQQRNRPVAPKYPKKRVLECLNRHLKKATSTSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWC3</accession>
    <name>A0AA38MWC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1143966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWC3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="266"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="361" mass="39246" checksum="683DF59EC6467E23" modified="2024-01-24" version="1">MSSSSSSLPLNQTKGFLSFFTISPEVASYFVAGGCAGAASRTIVSPLERLKIIQQVQPRSSDVQPYKGVWRSLVRMWKEEGPRGYMRGNGINCLRIVPYSAVQFTTYEQLKKFFTKHGSKELDTPKRLASGALAGITSVCTTYPLDIVRARLSIATASIPLIKSQSTTANSTLNLKPSVQNAFHTSSHPYTAQELTMWGMTMKIVREEGGIRGLYRGLVATAFGVGGSLSHRKVTQVLSGRVAPYVGINFAAYEVLRGIITPPGKNSITRKLTCGALAGSISQTLTYPFDVLRRKMQVAGMKSSALGHKYTGALDALIGIMRTEGIQGLYRGLWPNLLKVAPSIATSFFTYELVKELLIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWF7</accession>
    <name>A0AA38MWF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1159507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWF7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37266" checksum="B3D075EC63761AB9" modified="2024-01-24" version="1">MSPTPSRSSSPSDDEEKAEELRLQKKKEERIRREAARKAEEEEEAAAEARLAEIRRKKEEKKKREAEERKKKEEEERKKREEEEERLKEEERRSKDEERLAKEKEEKEEKNRAKSVGALVQASIARRGKKNHPIDVDSPTVVGKKRKRTRMIASNGDPESDDPNPGDDGEDSDTESDEYKDQKDEDEEEPEKTPTPTPTLTPRKTSKCDRCTSKDIACSMIGNGSASCIACRKARVKCSLVGNERRIRRSKRLRREDSVVASSSNERIDALEESNRELSRRLSLMEDMVRFIVQTIRPIDANEETEEDRVKRTGDVKGKGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXI7</accession>
    <name>A0AA38MXI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1095417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000061">
        <property type="protein sequence ID" value="KAJ3720709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="14"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="11">
        <location>
            <begin position="342"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="660"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3720709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="83900" checksum="A9F1CA66B1DD1056" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXJ7</accession>
    <name>A0AA38MXJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1089672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXJ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041412571" evidence="1">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="151" mass="16542" checksum="5A11318B32B27414" modified="2024-01-24" version="1">MRIVFIGLLFSILLVIVNPVASVPLFGKAKKLPDMKVIYPLPVTSTISNPGTNRFRVDAFADIDCERKPLGTISGENIETKDLKTPKGKCLMFILPMPPQCKLQVERPDKGARVGPVQQFGGDYTRGTMIRGSFESITIICKLQDASTSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXW6</accession>
    <name>A0AA38MXW6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXW6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="384" mass="42539" checksum="9AE25692F4ACDCBB" modified="2024-01-24" version="1">MLLLPFIAGSTSGMADTSSDSETDSAMSDYYTGNDNPQENTNTQENPSQDPLQNRSVSSPSHNSQSGQFAPGTSNVPQGPVQPPRTPPAQMVQMLDVFGPPVGDSDSTTPTPRAIGFGFSRIQPPMSPMAPPSKRRRGGRFLQDQPGQSSDQGNDHTNNESLGNQELLMRHLSDAIHSSHAELMRKQDDKIDKLTQRIESSSDVLCRVVEALDLRNKGRPLRGNMDLDEGVSSLGLQQESDQLRNGNTAGSRNHEERNISPFGYASRTTGSRSGAVKHRSPQELRDKACGYNLDLQELMRYWWNDIMQGRNLAENEVSREEAENFAKIYKANPLARPCTVDNFRYWLAGGPKSEWNQAASYIFVEILEQKRLITTPDASMRDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY83</accession>
    <name>A0AA38MY83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY83"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27566" checksum="1B668403511409B4" modified="2024-01-24" version="1">MSGALLSSEMPSKLKGGFDALFLAIEQVEAQVNAVLHASFQGHFQIPSSRPTTPPPVTYNKCPASESPQKPPLKRVGGRGRGRGHGAKSSGTAPHSKPSIAGMKTSRVDDPPNDDIFTSGRWNAAEQTALFTHIFGSDSDRIHAKWLKNKDRVYTKYLQANHSVAERFTVKSVASKITSSITMYGYMREYEEFTGGGGDANLQSMVPESDEWHKQWLILAKWHFRIKNSVQKIGLRGGGLGQNALGLLGMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYE0</accession>
    <name>A0AA38MYE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1090382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYE0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3724263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="23145" checksum="254888BFF2534BEE" modified="2024-01-24" version="1">MEVINSRSALLSNFEVLELLRDLENDHLARTKTAIRVKKEEEASGIPSQAKHPATIEVTENVRTIQVEAIQYLTAEYQPTSSQTPNGITQLVKDLANYKLTKAEKLQIVNLAPTQPVELYVIVEELEDRLGESMETVLSTVSASLSAAPSHPLNASSPAPVLPMASSDTMGDLSLQYPSEDFNDAGMVNDMVFDDEGQGVGIEGDLDKEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYT1</accession>
    <name>A0AA38MYT1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_436833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYT1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="318" mass="35931" checksum="DBE8116310298021" modified="2024-01-24" version="1">MSQSNKLTPSHPSLERYRLDGMILDGFTFGIYTILTIYAVIAIMGGRSTHSKQWKVKTQCYILLFYVVVTFLLGAVGFAANARYTEDIWINFRGQPGWSPEELITDEFYFWYSRLAVDSQAIMVWIMNALLLYRCVVTWNYARWVIILMSTVYLAIVGLSTSVMVFAQKQAIFTNLNLQLSFLTLSCTYNILYTALVAAKILSVQQRIKHTLSAEYAQIYTSVVTLIVESAFLYFIFDLLFLISFAIHSDTEYLILLENCLIQGIAQLLIIIRVAQGREHAQHATVSSDSNVAVKDSTLASTTTVDEGSSISMKSRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ66</accession>
    <name>A0AA38MZ66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1146220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ66"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041280003" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="12">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="13">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3731371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="617" mass="65958" checksum="A3A236D4D1657FE5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N151</accession>
    <name>A0AA38N151_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_220910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N151"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="383" mass="42154" checksum="A1D7CB8C2647F155" modified="2024-01-24" version="1">MPFIHNEQTYAALENIRPLGEHAYTQDSGDLMAPTLPLPQGQISNEDIAIITLTAILILICGTAAIRLAHLVYYKKDASPRVVSCKTFTESSSTLPLTSTSTTRVSSSMKFIGPDDMDDFSDYPNEKIEQDITFSFPFARSETPPCPPRRPPAFLREEEEDIAAMLSIRAGQESACRRGHKEKKESESSLTTTSTAQDSLCPSEPRSSVTSVYSISIRSEDEEEEEDIEEVEVYEVKRAQTQSMEVKRGVLMSWRTSRPPSSVPDMPKVIISESSSDTGALYTVISGDKGFLQPLPSLLVTQPSNVSLVSTTSTVSVDLDEFPLPPSLPPLPKTQAMDLPLMLVVPDADGPQVLMSREEKRSTVDQVITLYEAICNSLQQPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1L4</accession>
    <name>A0AA38N1L4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1064022</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1L4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01801">
        <property type="entry name" value="Ubl_TECR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049127">
        <property type="entry name" value="TECR-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21696">
        <property type="entry name" value="TECR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="16">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3734205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="312" mass="35206" checksum="80D48BBB85829CFC" modified="2024-01-24" version="1">MAFSITVSAASNKAPPFAQKGFPLTIEASPDDTVEDIKKKIQAKIPKFYTSRQRLTLKSDKKPLANEAKLQDAGFSPGLELEIKDLGPQIGWKTVFVIEYAGPLLIHPLFYHLPRLFYGADVAHSDLQRMAFAMVEAHFAKRILETLFVHRFSHGTMPLSNIFKNSGHYHILSGLFLAYDLYRPGFSTSSPYIQGTIRNNPQFLWVCAGLWAFFELSNFSTHLHLRSLRPAGTRKRAIPTGYGFGLVSCPNYLFETLAWVTVCAMTGSWASYLFTIVGTIQMILWALKKHSAYKKEFGKAYPKRKAMIPFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1L6</accession>
    <name>A0AA38N1L6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_994093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1L6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041417397" evidence="2">
        <location>
            <begin position="23"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="657" mass="72796" checksum="38EAA64801440897" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N277</accession>
    <name>A0AA38N277_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1151968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N277"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="18839" checksum="619C3C24442EACF6" modified="2024-01-24" version="1">MYLKFAFLVLATSLFSIVGTMPLRNSNLQEAGNNHGDTPKSPQPPRMAQVKGDSPLKITFRQTNANLPILPPNSDYNPREIVESYLERIYNGVSHPRRRFHFVNEYQVLDPDLIWFRVDDDIVGNPCNRVCIVTANWKHVQADRVPAGALGHLYQAGDSQYPDYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2C7</accession>
    <name>A0AA38N2C7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1060036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2C7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="287" mass="31437" checksum="191102EB6ED02B5B" modified="2024-01-24" version="1">MQNTASSASSSSSISSQSELSPSIVNNLHNASAPVEILKRPAAARKKRLEDDPWTADVSTVSVNCLGCGHLVRLSTKSLYDNHHWLMHKQRCKRAGNIKDNPDIGQSSPRQPAVVQTKSKSKPKLNRKAKRPPSASSSVSSLTPISTPPLTSDEEGDVDVSSTEESELPPRRVPIRTSGKRDLLTEQYFARAHGIRIRLPPISPETPDTHIDWRNWKWSELRMPEFITGPASSTEHGSEDGADSDAGSVKTEFMTEVEGSKALRSRATRAQSSTKEEPMRSSSSHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N309</accession>
    <name>A0AA38N309_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_198208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N309"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041463601" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="24526" checksum="4D9431000F078398" modified="2024-01-24" version="1">MLPHISRPIRLLSLLSATTLAAAFSILPIIPRQTTDADFFNPLLNGGSMLDQVPGVLGEPLNVIISAQSSPDVLTLDGIINFAKAIGFSTECLGIHSGAPQSANLGDGNGWVNQTIELREDYGDPTLGTCLESLIGGNHFRVFVQNGTEHPTGALFLAVSTEENVTEGHTTAPDGYDTGRDLFSAAAINNGGTTSFGGTTYSTAGTNITGLIQPGSTGIEDGIATDGIVTLLTITIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N375</accession>
    <name>A0AA38N375_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_771794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N375"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="261" mass="29046" checksum="FF7EECB539434DE2" modified="2024-01-24" version="1">MSTSSPRSDVPPRGAGSNGGGGIPIPIPILTPSQNSGDDVNRDRDRSYRTPGLDSRYAPLPPSSVAGTPGSYTHGRVRQRSPSPSPRGPPIKRPRDDMYSPLPPSSSASYSSPSGYGNPPPGGSNVQRRPADYPPPPPPHMPHAQAGREMRDTRAAYYDRYDKYDSRPPAGGTYSSPLPASYDRPRSPPPPPRGAAYTGYRESRDVRDTRDLRDMREVREPRDTRDTRVMRDTRDLREMNDIRDLRDDHRRYSMHPPPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3G9</accession>
    <name>A0AA38N3G9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1054769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3G9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="408"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3735886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="747" mass="85432" checksum="3DE9926628A97D4A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3H7</accession>
    <name>A0AA38N3H7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1055080</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3H7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="14">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="360"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="508"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3735931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="585" mass="65811" checksum="A8D52C617961D99F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N439</accession>
    <name>A0AA38N439_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1050641</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N439"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3736755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="471" mass="51272" checksum="EDB2CF3E3264BF2D" modified="2024-01-24" version="1">MGQGFYEKQLIALISCCALFLFVEHILSRIKKVNRDAAEAQMEDGGRASNATLLGKLTRQYLFVYAMVMSADWLQGPYVYSLYREQYKFPERLVALLFVTGFSSGALTAPLIGAWADQYGRKRICLAFCVTYALSCVCIFVPYLPILLIGRSLGGISGSILFSAFESWLISASNNAGLADSDLSRIMGRASLVNGLVATGAGVVSNQLVSSTSNFGSPFLLSGTILVLAWFVIASSWKENFGSTEANTRNDSILQVGRLTQAWKVARQDKVLLILGLTQTSFEGSMYLFVFLWVPSLQEASHSSNISPLPLGYIFSAFMISMMLGSLLYTAVTSHYLTSSPRSNDSSLSVHAKLSSLVCAISGLALAASVTSRNERIRFWCFCVFEACVGMYYPVQGMLRGTLISNEHRATLSSLFRVPLNVFVVVSLLTGVSSARYAVLSASSVMLGFSAIMTGLVIVNHADNHSNSRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4H6</accession>
    <name>A0AA38N4H6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1129237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4H6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="135" mass="15189" checksum="3C5BF567BD5D4C3B" modified="2024-01-24" version="1">MGWQQTFTLGRRSKGCHLITEEVRSQIQSGLKDVQVGMLFLFVQHTSCALTLNENYDPDVRKDMDMALDRIVPESLDWLHTDEGPEVSHTKSSLVGSTVSIPITNGSLNLGTWQGIYLNEFRRMAHSRTIVATIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4K7</accession>
    <name>A0AA38N4K7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1047152</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4K7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041412442" description="CFEM domain-containing protein" evidence="14">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="15">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3737295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="163" mass="16181" checksum="DC96967CAFC359D6" modified="2024-01-24" version="1">MHWTLALATALLVTEFSSADSVRRQLDLPPCALPCLTATASTSFGNCSATDEACLCTNPQFIGNTTTCIEGACTGNDLQTAISAAESLCAQAGVTLNVSSILGSVSATATGPLQASGSASASPSTSAATSSVTVISSSNDASPGYVFPRLLGLGAGMAAWIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5K5</accession>
    <name>A0AA38N5K5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF974-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_987895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5K5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="3">
        <location>
            <begin position="191"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="73097" checksum="C525F8B44B8F8FD4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1U1</accession>
    <name>A0AA38J1U1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AhpC/TSA antioxidant enzyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1135045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000110">
        <property type="protein sequence ID" value="KAJ3712342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1U1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3712342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="205" mass="22664" checksum="674DFAB042D3A8E5" modified="2024-01-24" version="1">MSASIPDSDTLSKVSDLEVYDATGRKIRFGSFFATQRVIAVFIRHFFCGLYVSQLTSEYAKLSKAFEEAHIDVIVIGCGDWQPIENYSDITGFPSRKIFADPSLSVFHGLGMTSQTLARTPTGEKKASYITKGIIEGSLWSIWKALKNPLLIGKQGNIAQLGGEFILGPGNQCIFAHRMRHTEDHAEVLDLLDRAGFRSSSINNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1Z3</accession>
    <name>A0AA38J1Z3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_88984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000117">
        <property type="protein sequence ID" value="KAJ3711635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1Z3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="119" mass="13065" checksum="553F5E7A339BD113" modified="2024-01-24" version="1">MAGSISQSRPPPGRSSSTPAQSRSQSRRRTRNQTPHSFSTTGNDSDAAALSRRRRRQRGGTGTANAGGYESKKISEDDETKQDDKDSEDTLQLRLDLNLEVAVEIKARVHGDLTLTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3S0</accession>
    <name>A0AA38J3S0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1099125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3S0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="661"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3717651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="784" mass="87211" checksum="5F2B060CA4A7ED92" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5B4</accession>
    <name>A0AA38J5B4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1142681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000128">
        <property type="protein sequence ID" value="KAJ3710906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5B4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="514" mass="57694" checksum="B3067163A76B9FAA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6L2</accession>
    <name>A0AA38J6L2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_976160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6L2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="130" mass="14777" checksum="65EF7E2A104B87F8" modified="2024-01-24" version="1" fragment="single">VTRHNFRPYSLHKLDHHVRSRGDMSKGSLDALALSKGSIRDYPSLDSVVIPLLTYFNILIAYTQMGGNPNADCILSMGANAYIASLAEMAKKFQWAAVFDYHVEYMNLWRYEMKESNYHGWGPIDGPLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7M9</accession>
    <name>A0AA38J7M9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1082134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7M9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="195"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="488"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="780" mass="87413" checksum="FAC5BD73D460818C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J967</accession>
    <name>A0AA38J967_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1078122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J967"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28732" checksum="AA0D3393C4E2ADA7" modified="2024-01-24" version="1">MSKQQTSVSSAASFPSSSCTPPDVDRLATLSTHLRRLLPDTEKYPNPIDFVVPTWETLWRLVATSLAHVYDNEDYRHNFHELLGDPTPGRFRTTSLDSNLCTEWIINETLRLHPPSRHISRSFPLVKEHPGLQILVSLLPKFIRDRLRLDSIIRSEIADIESVHLSTDIWGPDALEFKPRRWERHAGAADSAPTLFAFGYGPLMCIGKNWAPMAAALIVGAILEGIDAEGLEIIGTAVIGGRAGWAGWEFKHPEDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9X7</accession>
    <name>A0AA38J9X7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1139504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3730989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1375" mass="145806" checksum="6C7AFD910BE08302" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAT6</accession>
    <name>A0AA38JAT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1184361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAT6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="757" mass="80392" checksum="026562D1F9645553" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAY3</accession>
    <name>A0AA38JAY3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1072791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1547" mass="162438" checksum="6D2D4650CC83EC1E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB67</accession>
    <name>A0AA38JB67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000181">
        <property type="protein sequence ID" value="KAJ3709469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB67"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="885" mass="95406" checksum="967CA4C77F3325E2" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBA2</accession>
    <name>A0AA38JBA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1031844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBA2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="776" mass="87256" checksum="D8EB5459DE0DF915" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBS4</accession>
    <name>A0AA38JBS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1196687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBS4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="132"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="600" mass="66862" checksum="E2858B523C062A09" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCC6</accession>
    <name>A0AA38JCC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1135211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000139">
        <property type="protein sequence ID" value="KAJ3710365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCC6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3710365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="486" mass="55192" checksum="FB880ADD7D7980ED" modified="2024-01-24" version="1">MSDSTSNHSKEKQDHPLKAVNESDVDVAAQLVDGKGEELDPQVAKRILRKLDIHIMPLMCREMTFADKTTLGQSAVLGIEETAHLNQNQFDWLSSVFYLTYLAFEYPQNFALQRFPVGKWMRQVVPKLIFFVLLVLVRSQLRSHAACHSFGGLFAVRFILGICEGAITPGFMIVTSMFYTRQEQNKRVGYWFLMNGFAVIFLGFVSFGLLHTNTENFAPWQWLMIITGLITLVTSVCFWFWFPNSPTTAWFLTPEERVLAVQRIKVNQTGVENKHWKREQFIETLQDPKIWVMALFAAVAYLTNQRQLITTLLGCVDGVMEILSIWLGISLAGVKGIGRAGSLVNLLPSHLKVGLLFGYWLSIFSIAPFAIFLGWVSGLVSGHTKRTTTNAIVLIGYAIGNFASPFVWKSVYQPRMGASILILLILRTMLARENACRDKETCQDDYDDIYLPSKELDSGISVPRRKIDKVFLDLTDLQNRDFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCK7</accession>
    <name>A0AA38JCK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1093651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCK7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="11">
        <location>
            <begin position="915"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3722029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1001" mass="113808" checksum="1FDB8D55BDBBB55E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCL2</accession>
    <name>A0AA38JCL2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1095883</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCL2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="254"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3720277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="742" mass="80321" checksum="167D0E14EC39BF59" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD68</accession>
    <name>A0AA38JD68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin/FtsZ, GTPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1008448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000106">
        <property type="protein sequence ID" value="KAJ3712744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3712744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="81" mass="9290" checksum="D1F17367F166F9B0" modified="2024-01-24" version="1" fragment="single">MISTFFSETSSGKHVPRSLYINLEPNVIDKIRNGLYRSLFHPETLVTGKEDAASNYARGHYTIEKEMIDTVMDKVRRLADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDX7</accession>
    <name>A0AA38JDX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1090012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDX7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3724956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34855" checksum="66CAEFA34BD18655" modified="2024-01-24" version="1">MPALSTNSGGEEGVFNVLLTGFGPFQNHKPENPSWLAVKPLHNVVIPLDSDPVVIDGQVVMRATSSKQWLVKISALQIPVEYEAVMDTVPKLHLRPPVLPDEVKDDFYPLPPDKGYDFIFHVGVAGRGPLRMEKLGHKLGYHMKDAVGRMAPIVKGPPSEFGRREIEDTVSVGEQPLQVGERLGLGFEMESAGDSYSARPNRGFGVGYEKFSDEIYTDIDVSRLVYDLRNSGIEQIYSSMDAGHYICDFTYYCSLAESKRNGKPYEKDRNTQVLFVHCPPVGQPLTTEDVTEAIRRIVFWVCSELAEIHDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDY8</accession>
    <name>A0AA38JDY8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxyneurosporene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_122093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDY8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="1">
        <location>
            <begin position="86"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="2">
        <location>
            <begin position="238"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40964" checksum="730287039EDEB914" modified="2024-01-24" version="1">MFLLRKTLSLLAVTSLTISTQLVAYAASFDGQYIQPNLTNTAVEWWWGSAVGTPESPGTPGPVLQFLFYQGYSVLADFNHTALPEYYITINGFFPNGTDFSLTVPATSGDISEGTGNAVTGTWGTVGAFRTSSDLKTMTVTFNASDAPYGISGSMKFTSNRENHYGCNVTDSPYFETSKPSQTLNETEQVFFNQLGWAVTIPGGTVDVDVTINGTQLQFTGNGYHDQNWMPLALNEFISSWYFGFAEIGPYTLSYVSAAPLNSSIVFNTGYLSTNQAVLQNQCSITGSKTTDISIIRPTGEMAGAEGTVAPSGWTLSYVVDDGTEYEFKMVPTGVNPNMAVYQRWTGLISGGKKGEESYEGVATFEWLNPGLNVYSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDZ3</accession>
    <name>A0AA38JDZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_124390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDZ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="264" mass="31368" checksum="E36779ACEF86B5C2" modified="2024-01-24" version="1">MKIHLTIQYPHQRQVRMSRTKLVDCQENEDLRSSVQTLMRLSWQHNVSQNHMSRNADSSLVEIARLQAELQEKDKDLTRLRASSRITEELSRENTIFRLQIEELTSRLEVSHGDVAAQKLVAEELTRESERLKQQLDEFRETSTHVPSVTGDQELQNLINEDLSRENRRLRNQARELQESLSQLRAPNDELESLKETTRELTRENRRLQRRVREMESSPAAQDGMRRQVEHLSRDNERLRRDLEQARRPVRQDLPPPPYEDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEE4</accession>
    <name>A0AA38JEE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1131397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEE4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="220"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="318" mass="36772" checksum="4E16B16E9CA34039" modified="2024-01-24" version="1">MSAKKIVKAIEVFALVLSDGIAEIGHRVLTRCVERHGQFAGIYGRRSGDEEIHGRKDYDDGYSRRGDRGSNYRRNEESRYGYGEEERERERRRDRDRYDRDGDNYDRNRERERDRNRDRDRDPKRSSRRRSESPHSRHSPRPHSRSRSGSPSNKSKPNFGASGLLAAETNTVQSIDGKNSSVLKYNEPPEARKPLLGWRLYVFKGDEQVDLLHIQRQSAYLIGRDRLVADIPIEHPSCSKQHAVIQCKFLNRLVQEKDEFGGSKGVVKPFIIDLESTNGTHVNDDKIPASRYYELKLNDVIKFGTSNREYVLLHDDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFB8</accession>
    <name>A0AA38JFB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1160869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFB8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3714327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="560" mass="64953" checksum="114C8F67615F6CF9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG06</accession>
    <name>A0AA38JG06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1144799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="55"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="377" mass="41676" checksum="70DB89A77360862B" modified="2024-01-24" version="1">MDVNARRLVGIGAERVSHVSSTDFPGHYPNEDHSWNLQLFKQNLTVEIQRLSQRSIEFDIIGVDASIANAFRRIMIAEVPTIAIDQVYVFNNTTVIHDEILAHRLGLIPLNVDPTHMDMLEEGDTPTDRNTVEFKIDLECSWKDNKGKASASGSSTPTDDERYVNHQLLSKHLQWNPAGEQIEKLKNAGPLNGDIVLAKLRPGQAVEIVLHARKGLGKDHAKWSPVATATYRLHPNIVIKKPIPFERAEEFQKCFSPGVVKVDKKKRTVKIDPKHMRNDTVSREVLRDPEFKDSVELSRIRDWFIFSVESESAYKPEQLLPEAIVIMKEKIAAMKTAALGLLGGEGGGGGGGGGGGGGGVEGVQQREGEDVVMQEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG43</accession>
    <name>A0AA38JG43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1102793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG43"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="610" mass="65727" checksum="A386767A856DF2EB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGB6</accession>
    <name>A0AA38JGB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1085233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3727990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGB6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="121" mass="13875" checksum="2594E4C530E4D43C" modified="2024-01-24" version="1" fragment="single">MVGSLNPSENVVETFHFVSIVVETIFAVIAQNFGRSIRVIPMLPNPMLPIHVPLVPVSYRATYEFRPLTFRFPAEVFGFLNFELSFIMFYILFTIFLLCFRIPRSSESPSSVTLVILMLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGG4</accession>
    <name>A0AA38JGG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_862582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGG4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="97" mass="10625" checksum="43FFC6E2E0FE833A" modified="2024-01-24" version="1">MSNLFNKMKSKATSGGDNGQEEQSFSIQPHPAKTNNPADLQNPAPGTGMGLNNSEQMAPFHARDPHVPTDPQVLEAMGKQEGRDELRARQAELNREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGS5</accession>
    <name>A0AA38JGS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1074562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGS5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045564">
        <property type="entry name" value="DUF5910"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19287">
        <property type="entry name" value="DUF5910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="289" mass="32810" checksum="F01DFC45100C6271" modified="2024-01-24" version="1" fragment="single">MRNHANESLTIPSRSGAMTWILQAVFIATLASLLRGTTVWAMPLPSNSSYPISISDANGSIPASNYNYVRSVNLGPRQPTEDPKSSSLWNTLLENGARLRKTLTDQGTKLLDQGTMATDTFIGFTYAPPEIGQDRKGKFTHVTKLTFANPAWNLLSNGIYLLPKLELPEQNPNNEYWSCMVYAKKKKIDEMKSHMFYEKREPYLYNDNVENPPLYSPEPPKYPTPIVFFENEKFPNIVAMRIPNLETCIKEWDLAANCYETTKGLTGFKAPWDNWRTSIKGLPQYVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGZ3</accession>
    <name>A0AA38JGZ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1094060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGZ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37539" checksum="3EA910AF0EA74EF9" modified="2024-01-24" version="1">MNMRPQSSLSFFSTLTVNGNTEHFSFCLDLSRSESFPSHRFSCVDDEFHADTRYSTYQVPHNAAHLQLELGDCLGYGGTGTVYSARVSNPLSDLPPSVPSELVVKFARLNRCRSLAREAWIYNYLDENEKLTGTVVPRCYGFFTSKLSESSVECTTTSSFELPFELPWSVYEYDRDPHRDSILEDDIGKLVRPRTWKPDHIITKESSPWNSWAPDPDDPLVAVLLLEKGGQMYTMFDDKDPLVQEDVQLICEDLELAGVAHNDFRMPNLIRAPLATSVCPRHKRVHQWNIIDFNQAWPLDLSVENYPRDTDLVLDLDYRSGYFYGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHF8</accession>
    <name>A0AA38JHF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1151350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHF8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="410" mass="45756" checksum="28CF06A93ACD3D25" modified="2024-01-24" version="1">MASDEDSNAIALKQWMVRNGGYFNLDTRFSKTYSGFSVIAKEPLPFDSTIVTIPFRLAITRKNAVEALAQILKAPSALDSWNERQCIASYLCFHRILNGESLHLQHYHYVQTLPTPEQLRTGLFLTLEERELFQGTNMYGAIRDREQEWRSEWSRCHAIVASVNAEWADAFTWKLYLASASHMSSRAFPSTLLSRTPSLVSSPSTEPILLPGIDSLNHARGQPVSWAVTFPDEFDNVSEPCVSLILHSPTSAGSELFNNYGAKPNSELILGYGFSLAENPDDTIILKVGGSDADTKKWEIGRSARGVEGLWAEILSLVGQTSADEEISYEDELDASSMLGEMVRVVMEKLPRPGRSLDPGRIRPEVIEMFRTYIEGQRDILDSLLAFANAKEQTAIERARSEGVDIVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI05</accession>
    <name>A0AA38JI05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_997241</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI05"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3732462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="186" mass="21385" checksum="2AB5628B44304C04" modified="2024-01-24" version="1" fragment="single">ERHLFSLYFMLPLVAVCSGFMYHNWYPARAFPGDTLCYVTGMAFAVVGIQGHFSKMLLLFFLPQIFNFVLSCPQLFGLVPCPRHRVPRFDKVTNLLHPSKAIFMKPPSKLAATVLQILSFFKLVDLTLHLSRVILETTNLTILNFFLVRLGPMNKKKLVQVLICYQVSCEIYYPCFNRVTGYLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI36</accession>
    <name>A0AA38JI36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI36"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041458931" evidence="1">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="222" mass="24717" checksum="3A24BFDD7E4A6B4E" modified="2024-01-24" version="1">MLYIFSKSLVALSILGLSLSLAIVNALSVPKSSRAVLERDTRQSDSAKVILGYMMFMCIEEQETFVHGNKLKLDDFKEYDPSPVYTHSVSASPDHGQNLKQDEDEDKFRECIIYDTNGLIKAAQGHQLLHYHEKLNLAKKMPANGGGLPIVFTDAHVVKPPTLDMYLPITAIKNNPPTVECGPIGGWKDKPKVDWTTFGITDLPTTFKSTSALFGEMKMNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI68</accession>
    <name>A0AA38JI68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxylic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1098553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3718118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="522" mass="56576" checksum="7A443817B3A477EC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIV5</accession>
    <name>A0AA38JIV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1132057</name>
        <name evidence="3" type="ORF">DFJ43DRAFT_1132070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIV5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="110" mass="12358" checksum="BA6C5FAB1729082B" modified="2024-01-24" version="1">MSKHHPDLIMCRRQPGIAIGRLCEKCDGKCPVCDSYVRPETLVRICDECNFGTYGGRCIICGSPGISDAYYCAECTRLEKDRDGCPKIVNLGASRTDLFYERRRLGFKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIW4</accession>
    <name>A0AA38JIW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1087583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIW4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3726504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="297" mass="34813" checksum="CA04A2F6571B07AD" modified="2024-01-24" version="1">MAGYFFASPIDIDVKLEGEDVRKLAETKGEKDKMISCPVYYDGDTVSGQIHIRTRDGKKVQHDGIKVEFVGSIELFYDRGHHHEFLSLSQELASPGEMRQAQTYEFAFKNVEKQFESYQGINVKLRYFIRVTISRRMADVVKERDIWVHSFRMPPDSNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIFFLLVRIKIKHMELSIIRRETTGAPPNQYNESETITKFEIMDGAPVRGETIPIRLFLGGFDLTPTFRDVNKKFSTRYYLNLVLIDEENRRYFKQQEITIFRIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ12</accession>
    <name>A0AA38JJ12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1005154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ12"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="33"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3719645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="334" mass="36908" checksum="A917A4D1273FB016" modified="2024-01-24" version="1">MASTSISKAEKSYIQAGLLANPPRRADGRSLHDFRVISLETGFAPLSNGSAHLSIGRNPHNGSGGTDIMASVKLEVESIEEDASDGGRIVCNVSCSPSAYPHLTSGALDDLQYDLTTVLHQTLSHPSLHPKNLNIIPRKKSWLLNLDLLVTADAGNIYDALFMAARAALWDTKVPRTRSVEYKSPKSLSSASGDMDVDQDTTSGFDTRKVAHATDFELPDYWDEGEILEGRERWPVAITLNLVKTIHFLDATLQEEASCASRLLVVHSYESPISPTVQSMRMLGSEELSILNLKNLIKEAESYTNTMFSSLTAKLEDEDFRRNQKARERFGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJU4</accession>
    <name>A0AA38JJU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1049962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="248"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="427" mass="47044" checksum="A4C52DF2C0618612" modified="2024-01-24" version="1">MSQRKGFQPHHDLDTKMMNTNTTNTIKIANVSNNVRGEVVALFNTLIGDVRSTSEFRDAIGTHIEITFNSHDAAKKALCMSGYTIGGCSLLVTPVFKEDDISPKLPDNRRNLYVLGLPFDFTKGEFAAIFSRYGKVAHCVILATVDNASRRRGFVVMASHEDAKRAMMALTRTQIKGHTIDVSWSIVQRSQGFLDGGDRATVFDPHSSSGPEGSQGNDDPVLPTTDSSETVASLPQEESFVLTFTPTNSLLVTNLPFILFANTSDLEPLLFPFGSIKKLETITLPSPQETTSALVEYDALESATEAKVSLQGQCYAQYRINAEYVVFSDASPVPPVAAFSDFDDFEFKTDRNYGRNNLFSTSAPSSRSQSRNQSNVFQQKRPLQDISNSFNYLQHPFAPPPLYAPKSGPLTRSNSANSRYDPDLVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJY8</accession>
    <name>A0AA38JJY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_235067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJY8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="252" mass="27895" checksum="276FC24F7CFDB27F" modified="2024-01-24" version="1">MTSSAIVASSTPTPLFTEENSKKSKLPAILGGTVGATVSILIAILLWVLYRRCRRLHHRHAQRQALGASSPPTTTFHADMMMKPQGKKAMFPVFEPLGIVGQPKGTSRRSMSSGSSRSIDSTHEKSPALGAFSRSAMRPGSLEEYHDEEDIDDDGHDDGSSLVTMKNDRGPSRLSPPRTDRQMELEQKIYDLRAQMITMSHQEEGGVDVESHGSESAMHWHHIRGKIKRLEALEFSDWALGMTNQVPEDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK95</accession>
    <name>A0AA38JK95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1064232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK95"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000312">
        <property type="entry name" value="Protein phosphatases pp1 regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="350" mass="39601" checksum="59429C6EE30E8FC5" modified="2024-01-24" version="1">MAEQTDSFAANVTPDVTGKSARVALPPPDSSSDEEEDGAEEHYEVEEGNFLQDWPDDTEDLELVHSRIGSLDELHLARFANHLKRLCLRQNHISVLDPDVFQLLTKLEELDLYDNKIKDPGHALNHLSNLSVLDLSFNLLRSIPESISLLTSLKTIYFVQNRISKITCLDNLTSLRSLELGGNRIRKIENLDALVNLEELWLGKNKITKLENISKLQNMKILSIQSNRITVIEGLEELTNLEELYLSHNGVKKLEGLDKNINLRTLDVGNNFIPAIENVSHLAHLEELWMNGNLIPDLRALDSQLAHISTLETLYLEGNPCQKNDASGYRRKIMLALKQLKQIDATYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKI7</accession>
    <name>A0AA38JKI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1092042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="MODULATOR OF FTSH PROTEASE HFLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911:SF2">
        <property type="entry name" value="PROHIBITIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="1">
        <location>
            <begin position="267"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3723489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="586" mass="64479" checksum="61F3A8CAB189A08D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKN2</accession>
    <name>A0AA38JKN2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1128886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKN2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="294" mass="32633" checksum="5173B322E2EA26C0" modified="2024-01-24" version="1">MASTSSKCKSIALLVCDTPMPEVVAEHGEYPKIFHELMCKSLPDELGWDFKMDAYDVVHHMNYPSEDKIDRYDAFMYTGSAASAYADLDWIHRLIEFTAHLVKDHPKVRIFGICFGHQIVSLALGGTCVKNDGKWEIGPTNIRLTDIGKSVFEIDGKLTIQEMHQDHVPFVPQGFHLLASTDVSMNQGMVSTFGSDYHYTPTVESRYTSSLPSSSLDSSSPKSISLSDIHIITVQGHPEFTRPIISTMTAKRAKQGIITDALKEDVDRRQDALGSKLSGDGELVGRVLWKILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL35</accession>
    <name>A0AA38JL35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_641386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL35"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="220" mass="24500" checksum="221503A567D57E93" modified="2024-01-24" version="1">MSQCLSLQTYHQYYALILQVFIGVLLLLRTYALYERNFKVLVLLVVVGLALLIFGISVLAWGRNEIQFQATVVVSNELGCQLWLNQQNASCLALVWGGMLLFDFLVFSLTLYKALTLQRDGRVTLLSVLMRDGTVYFGVMAISIIANILTFMLGIPETRGMATTFTNSISSIMISRLMFNLRDPGLSRILQHPTTPFLHSPAPPHAAVATLDSLQEEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLU5</accession>
    <name>A0AA38JLU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1071555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLU5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="670" mass="74569" checksum="5947D0E4F691B5CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLW5</accession>
    <name>A0AA38JLW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_998016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="13"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="660"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="771"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="930" mass="101943" checksum="3C34EB84D02FE2C6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM68</accession>
    <name>A0AA38JM68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_991854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="250" mass="26549" checksum="435B932F3A771942" modified="2024-01-24" version="1">MTADRESISPSTYTDVERGWINVKECSGHGPSASTGGSSTIPIISRGHTFGRTATGNGKIANPGPAGAMSFAATALLLSLFNVQAGSVEHPEVVVSMAVFTGGLSQFMAGMWEYPRGNVFNATLFSLYGSFWMSYATIFIPASGILAAYKDPLELSHAVGLYLITWTIVTAFFLFVVVRRNLALTVMLSTIFITLVILSISQYSLAGMPIVQKAGGVFGIIGALLCFYIGVSELLAAEHRPIVRLPLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMT2</accession>
    <name>A0AA38JMT2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1072938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMT2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="117" mass="12635" checksum="60AA9699CB06F57F" modified="2024-01-24" version="1">MIQTGDPTGSGKGGQSIWGKPFADEIRSTLKFNARGVVAMANSGVDTNKSQFFITYAKQPHLDGKYTILGKVIDGADSTLDAMERIPVNPKNRPLSEIKLTHATIHANPIADSQLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNA9</accession>
    <name>A0AA38JNA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1153201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="204" mass="22296" checksum="5686C6164DD32D21" modified="2024-01-24" version="1">MTSTAHPNLDPYVTKAENNSVSPHEKIKDLHEIVKSVETGMLTTRASTGHMHSRAMVPTAPQSDTQTSLIFFANKASHKFDEIENDAHVNVSFSNTKTTSWASYAGIAKISQDKELIKKHWHTGLSAWFGDLKDGVHKGNENDPRVAIIEVIPDEIRYWVATKGAVGRALETGINAVTGGVSVPGELRTITSSEIQLTQGLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPV3</accession>
    <name>A0AA38JPV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1131428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3733416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="557" mass="61802" checksum="738E6D57F9B625AB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ11</accession>
    <name>A0AA38JQ11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_66019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ11"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="179" mass="19893" checksum="DAEA6C85E9E926CC" modified="2024-01-24" version="1">MSGYSDPFEYLKGLTFILEPQLRIIKSRGGADDDIFQVPLHWHEDHDEIITVLEGKLKVTLGGETKVYTPESGEAFVPRGVPHALESFKGVPCVVTERTNPSEFDTKELFFRNMLSIPGGLSSGGLLSVMQVFYHGDGYPVFPVHVAWLEKAFVKILGGYVAPLLGHRLKYKSLTEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQB6</accession>
    <name>A0AA38JQB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1063081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQB6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009187">
        <property type="term" value="P:cyclic nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="201" mass="22498" checksum="9F08DBC92787A72B" modified="2024-01-24" version="1">MVVLWIVPSDEDSAKLKTIMSIHSATSTGSETRSYPQFHPHITLAAPPSSSTLTLEQLREAISNSLSANLQVSFKSVNTGNHFFRSVYISIEPTPALVSLHTQIHNTLNLEPRTPLFPHLSLCYITDEDDAKTEERQRWKNQLEASSRIRYTGSSRNGIELNCCGDGAVDDWITGFTAYEIWFVDCVGPVESWSVLDKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQX2</accession>
    <name>A0AA38JQX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1061995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQX2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="284" mass="31483" checksum="647373070B00B17F" modified="2024-01-24" version="1">MALPSTKCLDHIIYLTPSGSVNETAEEFRKLGFNVLPGGQHADALTENSLIILGDGVYLELISFVKPVDAYPPDSPERLARENHPWALKAPGWIDYSFLGINSETVHIFDIINSRAKEGGDDDLYGPEIPGGRKRPDGQVVKWVITPPRRPAEGIERRLPLPFFCGDVTPRNLRVPTDPPAIIEHSCTAQGIASVRFEVPSGRWNELSRHLSYVIGNPGVASADAGHEWLLDTVKGVEGRNCRLLLSRSEKESLGIVEVAFYVKRKPEKETIETPYAQIRFVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRN0</accession>
    <name>A0AA38JRN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase II-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1075571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRN0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="424" mass="48341" checksum="A7656DC7D829C0E1" modified="2024-01-24" version="1">MSFKKSKLDLLVRVRYANPLSPPPCPPKLLDIPTDPMRYAQPEFLNSIANNTPLPMIVDAECGMPLDLGNWESLWEENADDSALNPDPHNLPKLDPKDEFLAYDSGSSSAYMNGNHTGSSTPSAVHSLGQVAWLRKTEYTSDRVQRSAANESKHVALPPIDVSREAQLRDIETSFLECNENFSLEELRHPNKPNVTAVESYEILPDSKIWANQYDLFRFSERPGERPVDVEDPRLDCAILRPMKSDHDSFLAFYLTEQDEGALKFNQVRSSVQPYEIPENEEPTVFKFIRDYETVKVEQEVPNEFLLVFEDGGSTSTFEDVFNDRKPAKRQRGAYYKNIERKMLLKKKRANAYEQYEDKWDVIKVTHVPMSQEEEDEREEALAEVMDPLFLMRGDVDADGEVEVDEGLGGHTFPVSVESIPVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS43</accession>
    <name>A0AA38JS43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1060312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS43"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="79" mass="8862" checksum="7EB8951F3F4F1DB3" modified="2024-01-24" version="1">MGGDGRYPYPKQVWSPAGGWWVRPSNWKSNTFIVATGIAGICYLVGKVSASKEQRYIAPTKQIPSAMWARQFQAEKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSC1</accession>
    <name>A0AA38JSC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_990009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSC1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="183" mass="18436" checksum="2CD9FCAAF1A9631D" modified="2024-01-24" version="1" fragment="single">MTPPPACSAGKTSSSASTLSGSTAAAKRTTASASITASGWSDLCASSGIGDLSTQYLCLNMGQDGWGYALSTAADACVQQNVADEMISFAKLPGILNSDDMISYAISYRQLPRQAVSVSGVVPSTLYCTFPPVNPELSGIVNAQPTGVSPGLFGSPSVPVVPFGSDGTCPYGSSPDASTCVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSQ4</accession>
    <name>A0AA38JSQ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endopolyphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1129505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSQ4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041328994" description="Endopolyphosphatase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="69015" checksum="7D1D7EFDBD8F46B6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUH5</accession>
    <name>A0AA38JUH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_971288</name>
        <name evidence="4" type="ORF">DFJ43DRAFT_980748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000119">
        <property type="protein sequence ID" value="KAJ3711438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="54" mass="6702" checksum="BCA7133326674EF1" modified="2024-01-24" version="1" fragment="single">ILIYDYLLTFDIEIERFWKRDTKRFASILFFINRYMTLLGNIPIVLLFFWPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXF9</accession>
    <name>A0AA38JXF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1128972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXF9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="154"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="292" mass="33869" checksum="93710BCC10CBE2C1" modified="2024-01-24" version="1">MSSRNFISLCRRKPSVFSRAFATVTESSSTPTQYPIPPQNARVKPKLLTSIILNRAPILTPTPTPFERAYYAYQARLRRALFNPFPYDFYFKQGSILEHRFTLEERKRERIAFGREFGVADELDKEKAAANKAAVEQLAEQEGESEEMMPRIHPSDDARDYKSLDRKGKRNLYLLLQENEGIWRFPEGIVKKGELLHQAAQRDLLAECGEYMDTWIVSRNPIGHYRPPKKAPSSSKPQPEEVAFFYKAHIMAGQARPNPETVKDFAWLTKQEIESRVPEYYWHGIKDMLSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXN4</accession>
    <name>A0AA38JXN4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_253514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXN4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041467396" evidence="2">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="196" mass="21127" checksum="76416044BE57C5B2" modified="2024-01-24" version="1">MRFLITLLPLITLAVHVVATNPGQSIPLNNVQPYPQPALHLSSSSSPSDAATLVDVDLERQQRPSAQRVQQRPSAQQHPSAQRPCDACLQKALHIAKDVVKAPGELLIASAEDLAERAKRHPKITFVIVMCFAVGTAAYGVYHVFREEHGVCVGCHVRRTGTSLPTPCQPLDCKDVCSATEEPGIVGGMRRGMLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JY12</accession>
    <name>A0AA38JY12_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1045985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JY12"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="512" mass="56628" checksum="80E914142C7375E4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYE6</accession>
    <name>A0AA38JYE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1151683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="297" mass="32394" checksum="7CA257A0E1B1EE7B" modified="2024-01-24" version="1">MPVCNICIDELKEPVCLPCGHVFCGTCIVRTVNSIKPATSFQPCPTCRTLYSIISVDPSTIPPPIRPHLVPSIRRLYLGEADVKPLASTTIPSAAVSECGRLAAENKTLRVNCAVWKRRAELHAAATLGLLNLARLARDCNQHLKNGRDDLQRQCNLLKRKLEAEEAFSLSEPIIISEKLSHTPQRCHSSKVASDLLPHSSSTLSSEDTELLAAACAPYARRISVSRASSAPAIIIPNSFSEPLEQNLQPSLKRRRVDDATPPPCPFASAGLLSVKLEMGTNTNPPLALRKRKELML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZ71</accession>
    <name>A0AA38JZ71_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_987280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZ71"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="178" mass="20231" checksum="3B321832BB40528E" modified="2024-01-24" version="1" fragment="single">MFNRILNVAVPDVTVRDLVSLSDDLRKQWVEHTRTQRVAKKDIPSPSTSFLTECLKLDYSTPLREIWVTVAGKKVEVGLLDEGSEIVVVRKDLWEEIGFKVNPTIKMLMQTANGGKEEMEGCAEFLELVVEGLRTWAHAFVVPRAPYKLLLGRPWQKSVKLAKEEHPDGRVEVTIHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K0N7</accession>
    <name>A0AA38K0N7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1049793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K0N7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="694" mass="76148" checksum="0543575D5475C028" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQQ0</accession>
    <name>A0AA38MQQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1104802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000096">
        <property type="protein sequence ID" value="KAJ3713763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQQ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="269" mass="30611" checksum="0A6976FCCA3F8440" modified="2024-01-24" version="1">MTMAVPLTVHNTDVGKWQWHSKRGKDNRGELTVSLVRRYGPLGEDNRKAAYSKILDSRENWYLYITHYHAFHAVQENQRWQLRRIDSGTSVAAGLILGTIQVTKFANRPQLMADFYSKIETITGPSQFEALNALIQFLTTDIPKGLEYTPRPEDRNAWTKIFLAMTNYDQYVQKFPSVALQDQYEKLPEGTTEAERDALISQGLMKSKKRKSQPATSTMASGGQSGEKLEEQGDEKKQRKSAGTEQGDEVQTMRIKNQMKISNMLGQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRA9</accession>
    <name>A0AA38MRA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_789047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041270320" evidence="2">
        <location>
            <begin position="18"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3717639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="319" mass="35011" checksum="DE5C425ACD9028F0" modified="2024-01-24" version="1">MILLQSVLASLFGYTIATTGSSLASGQIKNLVSFGDSYTDTTAMADGGATWPSYAAGYANVSLFSFAKAGATCSNNLTFRPFPSVFESQLPTYFAEVANGTLSYLPPDETLYTLWIGTNDVGANALLTGQGAPRVSLVDTVSCAIEWVKTMYASGARNFLFQNMAPLQNTVLYSADSYLNHYWTQERNTTEWNVFMSEITHTGNKLQELMLKALVPSLKDIHLGLFDSYSLFEDMIANPTTYLNGTAPLNITGCAHSCVYQLNESTADTGICTIANGTDRDSFLWYDELHPSEQTERNIAKEIAEVIKGERNQWTTWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRB1</accession>
    <name>A0AA38MRB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Telomere length regulation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1099141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRB1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="565"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3717654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="993" mass="109553" checksum="BFDE6E14E56D87E8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSP9</accession>
    <name>A0AA38MSP9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSP9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="163" mass="18494" checksum="05DBC7D69CB379B2" modified="2024-01-24" version="1">MYNPVFTESSLFVCDGTDPTSDLFCQDATMGIVFVAIVTVFLLGVVVIIMALIEGVCFIAAQAYTYLAKYNLCDKENVLKRREQAVVLRELAVNRQERTLQMDVEIKVCERLTQILRRSSASAQERAHELEIEKIAFGNSGLRRRHFWGGSLIHRLPKSPIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSQ9</accession>
    <name>A0AA38MSQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1084520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSQ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="70"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3729046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="196" mass="21717" checksum="B24DCCDDB0DCA4B2" modified="2024-01-24" version="1">MDNDYFSIDAILAENQKIQCKFKQRIPEMGHLGGGSERDILPLSKRQIPIWLAYIIVYSDWADFDIPQPFSNKVRNALRAEPRSVRLSNLVGAGAGWYVLGKTIMDMLGDEQGVEMSEMLITTFKGRLVDVIDQAQHFAVLGSVGGGGGGGVDSAPQMFREGLDTTERELFVLAQESARRMKKWHEEGSGGAKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSS1</accession>
    <name>A0AA38MSS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1083979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSS1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="281" mass="31733" checksum="81196C853F876B1A" modified="2024-01-24" version="1">MDVVITEDTLWLVTLWIADFIETLPTEINAIWRKKLTGASVLFLINRYIFLLYLIFEMFTNLSDNQKNKECDVNFNILNVLQILAIATTNVLFALRVYAIYNKNRIILGTCSVFIISRLVIDILVQITSQGSSSAGTQFQSFSACVINVPDSNVYSQVEFVIPFITLGYDIYIFGLTMRKTIDLGFKMKRQGQTSVAHVIVQDVVLLTAIIDAILARVSLHVSIHHNQQHMFIANLIDNNISSPFFTLLPNMLISRLMLNLRTFPTPGTGDTLTTSQRAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSW9</accession>
    <name>A0AA38MSW9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1040490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSW9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="561" mass="61077" checksum="256CBBC97E2C761C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSY0</accession>
    <name>A0AA38MSY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_999680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3730994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSY0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="175" mass="19145" checksum="74CE3F4299A8D1BF" modified="2024-01-24" version="1">MSIAKASSLSRCLQINVTRNALTHSHRRLLMTTSSLRNETANVGTPAVQKKPIGGFRGGIVGFLFGFSLASSFAAYQLLDEYKQASAALQASVEELKLSTQQVTTQVRRIEAVEKDLKALSDASASKEDISHVRAEMKKLYNGLNVELLDFRTHVSGIQQDVHALTQKNATSVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTT8</accession>
    <name>A0AA38MTT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1142776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000145">
        <property type="protein sequence ID" value="KAJ3710131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTT8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="131" mass="14996" checksum="D6D9D85FA10CAC72" modified="2024-01-24" version="1">MRDIKVKCKRIAEYCTTTHYVPEYSWSLSFCLILHIFNSILHCFGPFQMRSIVKAVQPERIMIEVPEAPDKVPSVGTVAVTQGCTRKGYTVLGSMMGLQQSFQQHSLYTIWVSLQSAKKKEVPERRTEPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVT7</accession>
    <name>A0AA38MVT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1007661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVT7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3714597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="91264" checksum="EF89EBD0B0A9E97C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWP8</accession>
    <name>A0AA38MWP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1099789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWP8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3717316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="383" mass="45355" checksum="F26B3B5FA8298280" modified="2024-01-24" version="1">MLDAPSAKSLNFRDNLARLIAPLRRVRPRVPFFRLAAHRIPTLWGLYRGLLRAAPTEHIYNRVCTLFKHNRHRTGTERTIQELRKGYKWLETFKRAEAGDVKTQALLQRYDRFLRLKAEKEHWARLVQKEVDWQKHLRNRPILTGGFVHPTPFHPPFPRMKPQPVAISRIIASRMKQRDRRFMKMEELTQMRDMVRKEQYMEQAITRDARRTGAEFEPVFEGQDWSSPLVKASNDIFSSVKATTERNLRPFSPELLEQVRRARQNKIANKTKERERERRGEILRSTRKRWRKGLTPHLLSTMSEEQKKKELIVLRSTAEVGYVGLLKKRKGWKLKKPKTEVEGKEWSVEDAEWIGTKEREAAAEALVTIQEENERRRDKVGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX19</accession>
    <name>A0AA38MX19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1003020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX19"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3724262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="197" mass="22659" checksum="1C9A98AED5117404" modified="2024-01-24" version="1">MSVKRFHALRHGQAIHNVQREWPERDPPLTEQGLAEAASVHMTFIPDLIICSPMTRTIQTLYAILSQLKDLPIQSNSDNDRVHVEIWPELRETHDHATCNLGRPRAELEAAYPSLDFSRCHELWDYPGHTDERALQRAEVILQELKARPESNVLIISHRGILQYLVGGDVFRNCGKERLPYIKSIVLLKIVPQSFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXB8</accession>
    <name>A0AA38MXB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1041488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXB8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="788" mass="88096" checksum="33E5635E65F5F1D9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYM6</accession>
    <name>A0AA38MYM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1080214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYM6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="249" mass="27795" checksum="2BE124D11D1DD5F6" modified="2024-01-24" version="1">MPSFDTCSRYQMYISAYTSVVEVMVPILLTMRVYAMYECRRYILWTLCITLGCLLPVVVWSVVVSSLGTVLLEGLVCDRFLPEKKATYLAITWGCALAFDTLIFCLIARISFQTRKTYSEMEIQIPLMSLMVRDGLVYYGVICFVHFTNIVLCATRSSSMTAFTRDLSATMVLRLMLNLHENVSKGVLHTDSSNDEHELNPRSAMMFNTNPALVSGIGTTMSMAQPTNNTATVKSRNLISSSSGFEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYR1</accession>
    <name>A0AA38MYR1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1155733</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="4796"/>
            <end position="5011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="774"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4135"/>
            <end position="4545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4612"/>
            <end position="4659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4193"/>
            <end position="4234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4248"/>
            <end position="4269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4281"/>
            <end position="4296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4313"/>
            <end position="4328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4363"/>
            <end position="4379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4465"/>
            <end position="4478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="4479"/>
            <end position="4489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4527"/>
            <end position="4543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3731220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="5014" mass="561176" checksum="FE0B2721DF67F80A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYR7</accession>
    <name>A0AA38MYR7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_435966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYR7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041388348" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="60636" checksum="FB71B04C13DC24F8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ24</accession>
    <name>A0AA38MZ24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ24"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="300" mass="32827" checksum="CBE5073B9E1DBCFD" modified="2024-01-24" version="1">MTITTTAKARATAPSRSRRVSSARAHREYDQSSAAQELLQASPMDEDLDLDTSTDDSQAVDRKKRATAQRQLVLENHPWVSKNSEDFNPKSVRCVGCNKVIQLDKRWEYYTTAWDKHVFRCATIKASYFEKGQDMPFESLVAEVGRDAAEKCRDERAEARATGIDLQLTSDPNWVKPVRIAKARKNSKLTVSRKPLSSGSSVPSLAASPSSRAASPRIISSPSTSSLSSRSASVSSPSTWSSTSASEVADVDDVPYHETLAYQIALALPRIAASHGYSYCCGALQKNPGAHELAHQMGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZF3</accession>
    <name>A0AA38MZF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1083867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3729184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="580" mass="64062" checksum="95FA19846E8277B0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0J5</accession>
    <name>A0AA38N0J5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_335431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0J5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="326"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="562"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3732122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="67245" checksum="E9BE8D23728042F6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0K7</accession>
    <name>A0AA38N0K7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1071499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0K7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="377" mass="42764" checksum="3CEF2D0243DF5112" modified="2024-01-24" version="1">MTLLDLKRQPQSSISPAFLYYLLSSTSTKASSTFKLLSKYLICAIILANIRGAPATWHWRVFWPIVKYNLQFLAFRVPNFFATLFDGRKRARRIAEYIDRTSPVGVHPFDFKVIYRSRVSVDESDFNMHMSNSSYPKILDFTRTKMATHLFPHFLRAGGVVPIASTHFHFVREIPMLAKFEVRAGIGAWDEKWFYVVARFVTVNHNSKSDGPSPVPSLTKSESDLVAKLVNSSKEDEEGVTLHTVAVARCCYKLGRITVPPSVLLATNGVCVYPHEVTLTELDPTIPGALDTTQSRYSVVNPPHTWTNHARKLALNPKNLRAFYQGAWRKDSTRWWESAMGTGGPMEESLKERLTICRKLFEGMDGIRQFREPASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0S9</accession>
    <name>A0AA38N0S9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1077398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0S9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="202"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3731778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="297" mass="31881" checksum="B62F613F88DA344E" modified="2024-01-24" version="1">MAPEEVDYEALSPNAGLAVNMLAGALAGISEHAVMYPVDSIKTRMQVFATSPVAVYSGVGNALTRISSTEGVRALWRGVWSVVLGAGPAHAVHFGTLEAVKELLGGNEAGNQWIATSIAGASATTAADALMNPFDVIKQRMQVHQSQFRSVFNCANTVYRTEGLGAFYVSYPTTLAISIPFNAIQYTIYEHLKRVINPTHEYSPSAHMISGAGAGAVAAAVTTPLDVAKTMLQTRGTSHDPEIRNVRGMLDAFRIIWNRDGLKGFGRGLSPRVMTTVPSSALCWLSYEFFKAVIRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0U1</accession>
    <name>A0AA38N0U1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_995758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0U1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="257" mass="29724" checksum="7CDA071E3FB64E30" modified="2024-01-24" version="1">MTIILYDFPAKRNEHTAWNPNVWKARYSLVYKSLPYRTVLVEFPDLEHTMRELGAAPTETKPDGSPKYTLPVIHDTATNAVVSDSVAIAQYLDETYPSPPLFPNGTHAFHASFNDLFPARIEPMLQFLLPSIASVLNPRSEEYFRHTRKEMFGMDLTELYPAKGSEKRDTEWRKFEEGFGMLDKAMRKTDILIMGGNAPCFADFTVAGWLRSFRTVFGEDSEEWNDVSRWHEGRWHKFMKALEKYESDVVQPVFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N106</accession>
    <name>A0AA38N106_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1155076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3732018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N106"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="106" mass="11616" checksum="278211505876D248" modified="2024-01-24" version="1">MVYDPNSNRAVSMEVLKTVMSNLPQILVHVKSSTGMVLYVAAHLRAAHDLLIILKKSPEEVEIIESELMSSASLQEFSAQVGNIVPDDIYLGCVWKLYLEAGADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1E4</accession>
    <name>A0AA38N1E4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50B-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1065432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1E4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="305" mass="32870" checksum="7D6166D0EB1081BF" modified="2024-01-24" version="1">MYTVNANDVLDGTFSSTALHRLLTRNVQSALTPNATQRTTLIVAGCYILVIGILWHIPILSWIIYPFKLLTVGFHEMSHAFMGLLTCAHIHSIELDPDEGGATSMSGGIPYLTLPAGYLGSSLIGAALIACGFDTNASKIASIVLAVFFLFTLWWAKRDWLTWVLILGMSGLIVLFWFVAGGVALRYLVLFIGVMSCMYCLWDIIDDTISRKVNSSDASQFAKICGCCPSQVWGVLWLFVSLIFFIAGVLVGLAAFKESAAQQKEDSSVFLPVPGSSAAMALTVTKSGIVSMILAVVVGLLGIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1N0</accession>
    <name>A0AA38N1N0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_144436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1N0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="992" mass="113449" checksum="CD6908ED9AABB51C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1Q4</accession>
    <name>A0AA38N1Q4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_995751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1Q4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26622" checksum="B7D4DE1897EEB6D4" modified="2024-01-24" version="1" fragment="single">DRGITTAIVWLTKPDDDDDGLAYGTEHGFLCIWKRNKNEHTFNEIYCNRLTGGKDGQEISAMAYDNSSGQLAVVHRAEAVHRFVIDGGMSPRTISSITIRDHWPQAVAFGQVGVRGPELWTFGREDGVIYILNDEGKILKAKTTGTVIGHAVLSTKDDAIILDDVSQGIALYKLSGTERIRTFQVPHNERRSRNVAFHDGTSTIVIGSDHGRVYEFDRRTGQISDIIDIGVRERVQSIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2D7</accession>
    <name>A0AA38N2D7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1038254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2D7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="238" mass="24977" checksum="60CB3EA099F2CDEA" modified="2024-01-24" version="1">MQPVRPRMKKVLLTGFVACMSLFHISSGAPIPRPTRPAEPTTASLPASSSIPNQNTGSSTSSSPSPSPSTTTRQAQANQPSTTPSRATSGPSTAPTPGAPPRPSSFSLGFNLGQIDYAAAGIARRVSRIFVKRMSAQSSRSTRSAQGAGAGVVQSQEGEEKEGEKEKERDRVTLVPVVESESGSLDPAEEDGDEVGRPVPVHDVDDPAHTEDDTSSVNEPKDGEMVAPDIRACRWGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3I2</accession>
    <name>A0AA38N3I2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_992284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3I2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57703" checksum="45AC28A065D30A8F" modified="2024-01-24" version="1">MSPHRKTTIRQFRISNDVLLSILEYLDPPSLWRACKAFRRIYSLTMEYQSLRYKHELAVSGMKDGAVAYSKAPPISRLHLLLNYRKDWLELSWNHEHRLQISLPAQVGSSGGFVHQIHSHEPFSTLELSELPSCRKNRPPALTRHLKFTTSVIDRVVVDLAQVLVVTGRVFSQQGRIGIQLHFRDLWSFAKHPRARALTYEFSSPSSAGAAIVRMTFLVCGSKLAISLEFSDGRNKHLIMNWLNFDARWLDDQDIHFLDETYLLGASTRSGSAVVSLYNVSKITSISVMREFELPPTWSNTIMKFLPNSSPRSDISQPSDALFYAAPETRVLAISSTPTAISHSEFYPMNWLFLKESYFRFPSRKDGFRVSWGQWGQYSLIKEIDVHPSAIRGPCVVGTKVFYVENAVHSTRSHAHSSRSSRLRVIDFSPFAEPVEYPRGWTSVGPRASLIPVESRRSIPTSSVDGLPVKDIIATEDNIVLFLEPRQGHSSVNVLTFGTPFEGSSRIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3P1</accession>
    <name>A0AA38N3P1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1150531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3P1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="347" mass="36942" checksum="38F12A5B344F8789" modified="2024-01-24" version="1">MLIILFSFLRDFLASIYSSANNSGFNSPAGILAHQQLPSLSPHPPHLVYNNNNNNNNNDFPLPNTPSPPSSSAGIRLPNAPLSDIAEYRNHSTGEYDSNEYTQYNSNDASELSGYPESYSGSYNASPYLTNHAHLPASISPSPHPDTPHSLPLPLSSTNSPYLGSSHLASPPHLGSPHLGSPGTMIPASLLEAPVSAGSSNGSTNTLMDMDTYPGSPETLIRPARPPVGGPRNKSHTISTSTPYEAYLNASREIRGQEQQQRDPRMLYPTRERSGSVSSVYSTNSSASSTRSTHSSRASSILHSARSVHAPLPEVGGEGCDLVVGVSGSMSEMHMTLDPSVLNGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3T2</accession>
    <name>A0AA38N3T2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis MoaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_104083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3T2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="156" mass="17440" checksum="5BA62327553A10EF" modified="2024-01-24" version="1">MLPPGSSVEGVVELSEAVCSISYALDTVESTIKRVSDDRFGAIATFIGTTRNSFQGKVVTKLEYQAYTKLALKTMTQIIVDARNHTPDFRAVVQHRIGVVGVGEPSIVIAVASPHRNEAFRTCEFILEEVKRKAQIWKREYYEGEDESEAEWKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N405</accession>
    <name>A0AA38N405_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1221799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N405"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="714"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="893" mass="97348" checksum="7761468B2A96B26D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N437</accession>
    <name>A0AA38N437_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_989106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N437"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016878">
        <property type="term" value="F:acid-thiol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF1">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="489"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="65089" checksum="99158A83690D6A89" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N491</accession>
    <name>A0AA38N491_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Squalene synthase</fullName>
            <shortName evidence="5">SQS</shortName>
            <shortName evidence="5">SS</shortName>
            <ecNumber evidence="3 5">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1048731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3 5"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N491"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000023">
        <property type="entry name" value="Squalene synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041326300" description="Squalene synthase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="493" mass="56645" checksum="625A62280AEA356D" modified="2024-01-24" version="1">MGAAAWLTLLLTHPIEFRTLLQFWLFHEQKRDITSMKEHATSGWDRQSMRRCWEFLDMTSRSFAAVIKEVEGDLARTICMFYLVLRGLDTIEDDMTIPDDVKQPILRSFHKLTVTPGWKYNDCGPKEKDRQLLVEYDKVIEEVNLLDPEYRSIILDITEKMENGMADFAHRAATAGATYIDKIEDYDLYCHYVAGLVGEGLSRLFSASKKEVSWLGTQLEISNSMGLLLQKTNIIRDYREDCDDKRYFWPKEIWGRKEYGFQEMKDMYAPGAEQRAQWVQSEMILDALRHSTDALDYLRLLKNQSVFAFCAIPVTMAIATLDLCFMNPAMFQRNIKIRKAEAASLIMRSTNPRDVADIFRQHCRSIHAKAVPEDPNFLRISVACGKVEQWCEQNFPSFVRMPSTAGNPPTFDAEDARTSILKKSQEIDQTITHRKRMAQLQEKQVAHGGQVKPAPEQPGIPWELFALFGAIFAILLLCILGVVWIVVKFSDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4C9</accession>
    <name>A0AA38N4C9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase III, subunit Rpc31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_989037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4C9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="207" mass="23401" checksum="F6B04C8F24A0AAF5" modified="2024-01-24" version="1">MGLSFADIQAMSREATALYPPMRPPIMTEPTEKEKRIAQLQIGFARRLRKSEYYVVESTKSTELPRYSDKYRSSPAFQPTLKRSDLHAPFFPTEIFEAYFNPRKKAKARKQVDQKRKLNLDEMLDDNEANESAQEGSDAGGSQGDPDYDTEEEYDNDYADNYFDNGEGENFDDLGDGGGGDDGGGGKNPAHFYRTYKFMSSQGGDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4H4</accession>
    <name>A0AA38N4H4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1150655</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4H4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="22"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3735888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="566" mass="62665" checksum="E1CCCE7A46E53058" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4L1</accession>
    <name>A0AA38N4L1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_988159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4L1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="189" mass="21173" checksum="0332560637FEB2CD" modified="2024-01-24" version="1">MSKVEDITISSLLNLFSFNGLYMILYSWLFGMSLWITFFGGIIAFKALPRQQFGNLQHKTFPVYFVISLGLVSGLLLLWTNAHPDAMTYWDRPLVADVLQVYILISVLIAQGTNYFVIGPMTSRTMFERHRLEKEEGKAYNEPGVSDGMKALNRRFGSLHGISSLLNLSAVLAIGFHGLWIGNAGVKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N522</accession>
    <name>A0AA38N522_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_989183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N522"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000069">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="419"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="530"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3736668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="621" mass="67551" checksum="794D55D6C14A988C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5E3</accession>
    <name>A0AA38N5E3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_404655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5E3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF2">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="74"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="914" mass="99107" checksum="D663BB52653FDD80" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5H1</accession>
    <name>A0AA38N5H1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_987596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5H1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="2">
        <location>
            <begin position="85"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="350" mass="39892" checksum="3BCC475E79F79032" modified="2024-01-24" version="1">MRAEKRIGTSRNPLSSDAEQTQAVLSAMDDDPNGTRGPRHIKESLGHKGIHISRYVVMQDYAPEGFHQRAPGTKVIHRTPLISNGPNDEWSMDGHDKLAKAGFEIYGIRDKYSGKYLHYVVLPSNRYAAVIGVVLLKCIKKYGVIPVQGSTDRGSEVRDAFSIHSILRQHFAPDLVEELIPSWNFLVSYRNITVERSWRPVFEKWGVNILTFYNTGLYSGDFKRDDELHKQTAAWIWYPLVQRELDIFCLEQNCHRVRKQNEKLLPSGGSADDFYSYPEKYGGEQCGIEVDMRVIDQLLDEAVEGKQHMCYVDEDFEQLAIAAHVAIGFPAITLHSAWSVFRHMIAHLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J240</accession>
    <name>A0AA38J240_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000134">
        <property type="protein sequence ID" value="KAJ3710634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J240"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041352232" description="Acid protease" evidence="1">
        <location>
            <begin position="24"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22646" checksum="02CB9463090E6911" modified="2024-01-24" version="1">MHRSWRLLSLAFIALISVSSVCTFPVKTIPQLHSRGNYMSTSSPVSSTSSPDTITIQWAKQTYPSNVKETSLKLEARELAAKDRIQSLMAEPKLLNGLGLASNPLKIVYGSGGSSFEQAYRKGKGGNASGQLYVDDGVSLDQMNGNTTFENQNGVLTVNGTFGYDVGVNLNVAGSAEVVGNGTFEYDKVMKVVDVSLGIPFDGAFEVHLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2L8</accession>
    <name>A0AA38J2L8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1008033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000096">
        <property type="protein sequence ID" value="KAJ3713775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2L8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26606" checksum="B8F205752E0EAF01" modified="2024-01-24" version="1" fragment="single">DRGITTAIVWLTKPDDDDDGLAYGTEHGFLCIWKRNKNEHTFNEIYCNRLTGGKDGQEISAMAYDNSSGQLAVVHRAEAVHRFVIDGGMSPRTISSITIRDHWPQAVAFGQVGIRGPELWTFGREDGVIYILNDEGKILKAKTTGAVIGHAVLSTKDDAIILDDVSQGIALYKLSGTERIRTFQVPHNERRSRNVAFHDGTSTIVIGSDHGRVYEFDRRTGQISDIIDIGVRERVQSIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2T7</accession>
    <name>A0AA38J2T7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_877240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2T7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041203398" evidence="1">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="203" mass="21759" checksum="CF84CA5C6654A67F" modified="2024-01-24" version="1">MRFNIACFVLGLFTAASAVPIAVENNNGAVEARAPFADHEFDLRQLGGATAVNVYHARGTQVFNARGEEIDARETFGLSSADLESREAFVAALSSLSKRAPNKVTISVTFTNDLSSDSNNPNRAKAQSDAKSAVQSLLNAAAKELSLEGKTLDVVFLNDYHTSRSEETSHVTFTFTETICATKCTGHAFGGSKGEIFKEDNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2X8</accession>
    <name>A0AA38J2X8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1103047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000087">
        <property type="protein sequence ID" value="KAJ3714952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2X8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041266620" evidence="2">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3714952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="249" mass="27409" checksum="09227D083EAD0073" modified="2024-01-24" version="1">MRFLPAGSIILTGIHALISSTLAAPASQKGLSTRADSAYNLPSRTFPSDTSGIESSQVRALVTESIEGGTEASGGGNHPQARAPPADEGNASESTRRARITFVVWGDEDKKGYHNRAPGYGSQSTEVSAPKDVNDLLHTFLEAWLQSIKPDDRRRLILIYMNGFYDVLDNGFIIPDQFEFSLTGVGNCRHVMPAIEGKRHRVVKCLVKVKKDEITLEVNKRISFTWAVPDHLWYPGKEEEKKTETVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3B7</accession>
    <name>A0AA38J3B7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1006608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3B7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3716771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="174" mass="19283" checksum="37DF3FB25C32C572" modified="2024-01-24" version="1">MAQKVCPSAVIDDFKQFMEQTGLISMDPKEFSGEGGSEYTVNYEGSNITFKGVDMAPPSGVFAQNYARPVHTEKQPHKYALSWTTFRKAGVCGGHFYISSHGLRCCASSNTFTLWDPSLPHGTSLQSISPYAEEIVQSGLSIVTGERLPGAFKRYRQNQLTEEQLARECAERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3H8</accession>
    <name>A0AA38J3H8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">beta-glucosidase</fullName>
            <ecNumber evidence="3 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1100707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 6"/>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3H8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="415"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3716730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="860" mass="94507" checksum="BC0D8A6C6EC4D57F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J464</accession>
    <name>A0AA38J464_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1097156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J464"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="303" mass="34324" checksum="9F0C14681CDE954E" modified="2024-01-24" version="1">MDLDQFASSGFSGQRSDNSADTGGPVTSMNFSQRSAPSPRHSSYHLTTTRQFSHSPTRKRVTSNTRERSNALPDIMQGIPLSIQRYLAESTAQTIRRAQNICEYEQEIQNHHHPQPWPVISQQDPNPLENASLPPASGPQRILRRRNRLRRMQSQEILVPFRIPMISSGEVVDICRITCTNPGSSDEAVFICGQRYDTAERLIQHLQMDHFSSSSEQVTPSVDASQPCLWQGCSGVSTIQEEDLINHIIRDHTPFRIRCTRCGVVFNKRARAVLHLWQSRNGRRAVPGEESWCEYWQRGSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4Q6</accession>
    <name>A0AA38J4Q6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1141688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4Q6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="27135" checksum="6417977EAED98DAD" modified="2024-01-24" version="1">MMVETGRFRNLASWRKGFKSEWKRLETRPIAQPVSDAYRPDPLRWVCGCRYFFKSRFLICKHLVQAMKPVPPVFFLEVRRSRSTPFWSHKALVLKMPELANLERSEGVNEDQWEVELYSGDILTANDYTEESEIIDAEEEAQGQKTFDESISEHITLLREFADGLEFQKQFQDQRFLDAFSREGSGLIQLAKRCLERERQVASSRSQNPRTWDTRSSAEMLYKARPSRTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4W6</accession>
    <name>A0AA38J4W6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Linoleate diol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_692766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4W6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3721377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116559" checksum="77C72E5D1001B054" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J533</accession>
    <name>A0AA38J533_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1158425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J533"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="64"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3722150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="389" mass="45336" checksum="256698EDCDFC971C" modified="2024-01-24" version="1">MVNNNNNDSHFEEVIGPLRRGSRRSNIYALDTSEEWWVGHFEYLRERGYMMRPRYRPGWKPSYDQDLRGIYKGMFAEDSQIMVHSAIMDARRISDSLVVAMKRVKISTSEDQIATLFSDDAHNSDPHNHCVRIIEVLPVSEGNEKILVMAWMREVMDPRFRTVGEAVQFLKEMVEGLQYMHQNNVAHRDCSMNNMAMEANAMYTRQYHPVRPKKRYDWSGRALHHSRTRCPPRYYLIDFGQSRMYDPSQPRGTEYALRSGGYTPPEGLADTPCDPFATDVFLLGNLMRTTFLDGDTWMEEPGISGFEFLRPLVKDMVVDDPSKRPTMDEVVPRFSDIIDKVPWWKLRARATKKDEFLLVKPFRAVYHVFWTASMMLLLKPAIPSPKPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J738</accession>
    <name>A0AA38J738_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1001895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J738"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3727242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="250" mass="28704" checksum="37B17454E63DD446" modified="2024-01-24" version="1">MDALIKRIDEKLTKAQKDLNFVPLKRKPNVRGTYDSLPIGGSFGGGQTRPAMFAHTPHNDEIVEGLRKDEDILRIAGLCDEYFESYVPKLHTLYDNVLNWLHEDNNEFERPFPNCAFAAATVNFLFAVTRRHKDFLNMIYGFCAVTPLGPYNYKQGGHLIIWDLGLIIEFPPGTVILLPSALLEHSNVSIVPGETRSSITFYSAAGLFRWRHNGYMSDKEFRARASPKVLKKWKQYRREMWKEGLELLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J867</accession>
    <name>A0AA38J867_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J867"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="801" mass="86049" checksum="99915182AA8B3084" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8E5</accession>
    <name>A0AA38J8E5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1006274</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000073">
        <property type="protein sequence ID" value="KAJ3717569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8E5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3717569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="414" mass="46542" checksum="3169EC2B7CD8BDEE" modified="2024-01-24" version="1" fragment="single">MLSGTDPEPGRELAVTFFPALYLQRRIWILDILRRENISDVLDVGCGEGQLLAVLSLPSPWLSTPPQSLIYPDGQFNLQISSVSPISLYNTPSDPIPNLHITRLAGLDKSSRDLEFTAQAIAPPDTSEPSFDPWRYKGSQETVRWEEMTAKLWQGGLEIINEEFVGTECIVSSEVIEHLPPHILPFYAPILLGIYKPKLLLITTPSYSFNALFTSPNSDPSIRLRSGFSDPTGRTDRIFRHEDHQFEWTPEEFRQYCEKEAANWGYTVDVGDVGRAQEADAWGRDHEVGGASLVAIFRRIDDKRQVDREAVEKQAREFVEVLTEQHLISSSSDGAPQSALPSSPTVHRLLKTHTHPAHPSAQNPLPIHSIGDIVKSRMEDLRESFLRVEELWYEPEVAQACGGWIELLIAAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9F5</accession>
    <name>A0AA38J9F5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1096128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9F5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="397" mass="44125" checksum="38782A3E116B3111" modified="2024-01-24" version="1">MSTSTPWLSNSFPTSSRLDVDSSALHSSLEGISLSESTLSESYNDSGHFASFVTLVAGLERSLNNEDPLFLDLDIWLSSNRTVIASGASSRVEKVGWNSGNFKGKYKERWGNFVALKYTRHHTDASRAIVNWKQLLSEVRALLHEPIRYHPNIVRLLGITWGAVEGMQSNFPALVLELSEMGTLAQLQLNSEESLSFDIKKKLCLDVAKGISILHACNVVHGDLKHENVLVYPNRDTSASVKYVAKISDFGGSVMDLGADDFRSLHTPTRPWLAPEFFSSNGMSEIELKLTDVYALGLLVWRTIVDGQNPYLPLHSDAEPMSDSQIYQMKCSNELLDLAKEGVLHLKLGIGSDGIDTLHYVFENTIQFIPSLRNCYDHAHRSYASRVALRTDATNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA66</accession>
    <name>A0AA38JA66_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1216099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA66"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="659" mass="74247" checksum="1D861D5C8F6329D7" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA68</accession>
    <name>A0AA38JA68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_431762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="424" mass="46398" checksum="26C49FEF246617E9" modified="2024-01-24" version="1">MLASDIATLTTPVQQLPSYDSVTSPPPLYSSDPTCGEQSIQLTPRARCLGRYTGTYVHKTSVATVLLLDQEEGVMAPVYGRNAVLSGVVSLTSRETVSEVKIKLSGRMDLVISGGVSQSTTLVNDAHSVWKSDPDTTDSDSTTCPSQIPFSCVFPSTFQDHIGREAPLPPSMHAMYPGTSGLVASCVYTLTIKIVKMGFWKQVKKMTITLNYHPRTRAPTFPNPNPDLFSDVKISPEEWHQTMSVIKSRKPAVTAPVQCHLFIPSVRVFALGDTIHFHVQLTGPLTSLRQLVYSKSSKRSSDKYAPNIRVYLLRQITVDVCGQKGWKNLTVAEGTLRPRPPPITALSSSTARSAEDNLDWEGEIRCDVDETRGCPGFVTADLTVKDFIVLSISPADATKSDLITTQVPVPIKLVTESAETWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA73</accession>
    <name>A0AA38JA73_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_997591</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA73"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="14">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3732281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="321" mass="35469" checksum="8BFEEB8CA62556D2" modified="2024-01-24" version="1">MPPKADINKAGWEQSEFPVLCETCLGDNPFIRMSKQEFGRSCGTCARPFTVFRWNPGSGMRFKTTVICQTCAKIKNVCQTCLLDLEYGLPTQVRDTALGFVNEAPTSDINREYYAQNMEGKLDGNKSGLDTSKAQSAGKEMLKQLARTDPYYKRNRPKICSFFVKGECTRGSECPYRHEKPVDNDLSHQNIPDRYHGRSDPVARKILGAHAESQGLKPPEDQSITSLFLTSLSPDSTELSIRTQVLKSLPTVQPTELKSVVHVTKSRCAFINFKERVTCEGAAVAWANGLEIDGVRAAVKWGRSRASKPPAPVTSSIAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAK6</accession>
    <name>A0AA38JAK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COQ9 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1072960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAK6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="1">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="213" mass="23380" checksum="E5539E443E993DC0" modified="2024-01-24" version="1">MADFRSQLLRIATSLVRTHGFTREALSRSVLELPAGKAHSEPLSDSAVSSLFGIGEYARKSLIEAWLNEGIIQMASKPSSSLSHVLHTRLNYNEPVLPYLPEAFALLASPERGLPPLDPRPALKHAARIADEASYISGDTSSQLSWYTHRASLAVMYSCAELHQLTSPETAHAFLDSLLTGSSAFEKSLDEVHFFSGYVLQSWKGILRSRGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAV0</accession>
    <name>A0AA38JAV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_845273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAV0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23969" checksum="5CC29B637F305D48" modified="2024-01-24" version="1">MAPVPQSLGGQVDNILKILEDNGTIDIPNDRWVAFPVDPAQATGQEDAVFHWQGLTTIFNAVIAAAQQIDSSLEHTFDFIVNGIHETREKGKSEQKQVGTGDVVTQNAGGKPPKNERYLVYDLANPHQFKLGDAEKDENDDFAKLVYDMEQILALDPCRRFTFGTTIENCITRLWFLSHATLLRTKPFDLMKDHHVVPNLPEQLTLISPSSWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBA8</accession>
    <name>A0AA38JBA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_996193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBA8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="78" mass="9227" checksum="231B58E3071CB1DA" modified="2024-01-24" version="1">MYLPIQVVHLSRFESPFQACPWLERNHREIQKLQKHVVLPSAPQTKPILGEDEDVFGYETDAGIRMRDYKSQADRMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBR4</accession>
    <name>A0AA38JBR4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_716707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBR4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="79757" checksum="DB212C51682EA18D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBT5</accession>
    <name>A0AA38JBT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inositol phospholipid synthesis and fat-storage-inducing TM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_205356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBT5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3733481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="260" mass="28579" checksum="F819C0C5F6E95310" modified="2024-01-24" version="1">MYDFRLVAFTAVTFAVSLGTAYSILHGTYLDTSDPLLAHLAHPLAKTDYWARKSNVLNVYFIKKAWGWTSAAFLLLWATSSPAARSLSRVMQWLTATACWLTFTTWFFGPAVIDRVILASGGECFVHLPSGELMTVPTDYCFTKSTVAPASHPDIFTSSLVLPEGWSGIPRLRRGHDVSGHVFLLTMSILFLADQLSISLRSGPSSLRHKVAVAANVALICIWLFASATTSVYFHSPFEKMTGYALGLVSFMFTQASVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBV0</accession>
    <name>A0AA38JBV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1067548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBV0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3733526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="873" mass="97253" checksum="182C6D33A0E8474A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCC1</accession>
    <name>A0AA38JCC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1152632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCC1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="48538" checksum="99A6DBA253227884" modified="2024-01-24" version="1">MHSGDMQGFLIDLDNLVPQDPTLRDFEPTRFPIASGNFYPRGSTDSGNAKALIYRDDLRAFSNILQWAIRGCFWEVGMDPWYLSSQGTIRKYFGCPKKSIFLEQEASATLTNLYDSLSKFWGSAFFFSRKMRENSGYAYETLNGRVMYGSFMGVLRSCGIQPDIDLRLASKTPLPLAKVDELAPPTLTMHSISEIREEQRVLEIFIRILKGRSFYNCLTFISWLIAVLVPDYHSYHQQTGDTNGELNPYYTAFCHDTETNEDQGIFVDLDSLPRLENSPEDYTPNINPISVPFLAYDILRSKAPTYYHRHDLESLVLILDWFYSCCSRFWHFEEAIRDVSRDTVSNSHSRRLRCMKYIETPFNAGGSRIDVVFKVVADSYWAWQNDVYQDDDDKADFTTLGGFLTYEKILEALESCRDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD44</accession>
    <name>A0AA38JD44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_78323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000110">
        <property type="protein sequence ID" value="KAJ3712341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD44"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="166"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3712341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="311" mass="34681" checksum="EE474C450340E8FC" modified="2024-01-24" version="1">MMSDTITSYTSLLMGGLVAFSLTGTVSVQCVVYYRLYPQESERLKGLVACVWLLDLIHSAFIGASLYQYFIAWFGEESQIDVIPWSVAFTVVITAFQTFIAHCFFANKIYRSSQQNVYLTAPVVFLALLRLIAAATSTGEMISDKHYSVFTRPYPGWIFTTGLTLSSVVDVLIAACLCYLLHKLKSQIGSASTVMIKVVDTLTLYTLENGFLTGVATTASLICWLAMPHNLSFLGLHFVIEKLYANSILASLNTRKELRDMRPRISPWADRSLPVLSADDFSDRPRDPLNPLVSNISSRLLLFLGVVYTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDK7</accession>
    <name>A0AA38JDK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DEK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1151695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDK7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45247" checksum="63BF02B88BDFD48E" modified="2024-01-24" version="1">MPPPDIKVIGKLTREIVSGADKSGTLSKLTPRIIREKLEEDLALEDGALKQLKHVIQEAISKALEEVRDDEDNNDEANEEDDWQEERQNVASKVETKRAARKEKQKKSTEKPLDKKTSQKPPKTEPSSSDIPAKGKKRKSEADVSSPKAKKPRVSNDAKSKVKRDKEAFTSAAVVPPSSDFEDDIPAKPTEDNIPFADKTTPRKPSSKRTPSPNEPKHDSSPRNSSQADSSPQMEEAEKSESELSVLIDEPPKRKKKGKAKSSEISEAKEKKKTRKGAASTSLSKEEETIKRLKSLVNACGVRKVWSKVFKDVNDSPSKQIALLRKILADLGMTGRLSLEQAKTIKERREFASELADVQSFEQSIKNQSSRRSRSVATKEESSEAEKDSDEENVRPAKRKVSVDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE09</accession>
    <name>A0AA38JE09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1062856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE09"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="471" mass="53253" checksum="2E204E46E9AC2225" modified="2024-01-24" version="1">MESVFATFTSLDIIPPFERGILFVVLLAIAAAIAYKSERRSPQSSQSTSGSIAYSEKSKLKEREWGEWPPISFSYPAVTSSQNPVNLKPIPYRPFKWGAYHVTMGIRDMPWDEWIEADNQMQSYYYIKKHRIATRGTNVVHILPDKAGVVKSASQAAVELVHDLAEYLSRRYPDAFSVSRSTTGSIASVTIVPVNDTLNLPPALATKPSLELRPVSIEEAEHAMKISALLVQDDLALMVEGTDGRYYFQGGAICVPGFWRMRDKIGLPLEDIHIQGHVPQYETKLHHSMDRYFKRMSVEKPIIRNNYFFQVIPPKDTRHSIDELSQSAAESIIENDSIVDPEELAWSTTTNGSEETFNHGHPINPDKRPVVAAENLRLRTERQTLRRLPLSGAIVFTIRTYLFPVEELAKEPGIPARMASAMRSWPEDVRRYKGNGLYEKVMLEYLDKAAEGQLRTGGEEMMKESGRGYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE57</accession>
    <name>A0AA38JE57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Semialdehyde dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1226459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE57"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3723501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="412" mass="44266" checksum="8050032DEDF4FCEF" modified="2024-01-24" version="1">MSSKITPNIVSPPKKIKVGILGATGTVGQRFITLLSDHPWFIIEALGASERSKGKRYREAVKWKQTIPLGGLGLGGIGTSETEKISSTDLRSDDRRVGDLIVKGCIPEEFKACQLVFSGLDADVAGDIESAFRSANISLFSNAKNYRRDPHVPLVVPLVNPSHFSIIPQQQRLHSPSLSKGFIVTNANCSTTGYVIPLAALEKAFGPIESVLVTTMQAISGAGYPGVPSLDILGNVVPYIGGEEEKIEWETLKILGGITDSETEFDKNGVPLKTFDMHQAGGRPALRVSASCNRVPVVDGHMECVSLRFHRRPPPSPQQVREALSAFTPEVQTLGCPSAPRKAIEVFEEPDRPQPRLDVKGTHNGAGVSVGRVRQCQVLDIKFVVLSDNVSIGAATSSIINAEYAVLKGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JES9</accession>
    <name>A0AA38JES9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_597087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JES9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="13">
        <location>
            <begin position="258"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3724271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="352" mass="37925" checksum="D3429A2E6ED210D6" modified="2024-01-24" version="1">MTRQFTVKVPGTSANIGPGFDVVGLSLSLHLTLTVTVPAASEQPYLAPVITYSGEGADEVPLDAYKNLTTRVALYVLRCNGIRFFPPGLKLHAHNEIPFGRGLGSSGAAVIAGVILGNELGQFNLTKERLLDFALMVERHPDNVTAALIGGFVGSYLRELDEADTEAASVPLSEVLPEYPPDAGEDWGLNPPPPPAGIGHYVRFGWSEPIKAIAIIPRFELSTAKAREVLPSMYTRKDLVFNLQRLAVLTTALAQNPPDPDLIYEAMKDRVHQPYRKTLIPGLPEVTSCITPTTHPGLLGICLSGAGPTILALATTNFEKIAEDARKIFRAQGIEVDWKVLTIAEGSQVNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JET2</accession>
    <name>A0AA38JET2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1041739</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JET2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3724286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="567" mass="64003" checksum="426838AC635B914E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF00</accession>
    <name>A0AA38JF00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1041634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF00"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041256700" evidence="2">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="225" mass="23277" checksum="FAB99A8AA67B7EE9" modified="2024-01-24" version="1">MRFSTLSLLATVASAAFSFAAPVSPASNALEARCLCQDIHSIIVDVTTTITPLVEELTYITAENCTVEILTPIIGEIKVVLSTAITEVKGLTGFTLTAVLTTVDGVVLTLAEVAELVCVLLTLIFGALAAILKVVTRAEAAAVAELLCEVVALVATLLELICNLLGGILAILLPLVGEIVFTVIASLGLTAPFSFFNVSWATVSSTLITSATTVYSTSVATMTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF36</accession>
    <name>A0AA38JF36_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1156545</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF36"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="656"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3728984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1044" mass="113692" checksum="511385095B2DF965" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF54</accession>
    <name>A0AA38JF54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1005868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF54"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="37"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3718116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="289" mass="32091" checksum="B9FD7DCA6D035D77" modified="2024-01-24" version="1">MFIVPASISAPRLPLLHIEDDCFHSEASTASIASHDEDHSYIRPTFPDDSRAPCPGLNTLANHGYIPRSGRDISFLTLVRAIMEVYNISLPLALMLTVPGFLIYARFQLHWNSSASFSDTESISQSFPSISYSITLSSLASFGPGLKIAHRASLVHPNYPSEKPDTNMLHGFLNYARLSDEQRGCFTIHDLASFRVSRESNLQGPNKLDGIHEQVALGESSLTWLLFAKQISSSTSPEISLSYLEQWFGEERIPDGWTRPTETIGLINARKVAGQVQKEMKIVREAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFA6</accession>
    <name>A0AA38JFA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1122456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFA6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="355" mass="40064" checksum="39E46B86129E3C5E" modified="2024-01-24" version="1">MVYSTYFVTGASGLLGSQIVQKLLDAGHTVRGSARGEKVSQLRKVFASYEKFSVVDIPDLATSSLGDAFKDIEVLIHVAAFLPSFRGDIEVVKRFSTEGTERILESARDAGVKSIIVTGSQVTYNIDGPIGPRDWRFVTFDDAQKATEAQHFVVYIAQKILSEQTMMNWAEKHPDVRVVIIDPTYIFGPFVRNYKYIVNHPSLYGLESSNYFVHFLLRPENKVFVVYPGWMDVRDIADAHINAVHNKAIDELLPKDRRFILGAPEDHDWKKVISHVVEARPHLADRLCSSEKAPVFSMQVTDLQRTEKYLGIKAGSYTSFGKSIVDTIDSILDIETYWKERGVEDLSLPNEPLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGP0</accession>
    <name>A0AA38JGP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_626565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGP0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="400" mass="45176" checksum="32E7B6CC5646A8CD" modified="2024-01-24" version="1">MAHHNEVNDGKLDSLTWTNYLNIALLLTFRLPFAILQTIFSPFIHNANGYNDKPLKRRIGDALMRTASIYLPTPIMQHIVGSGLDQYRQWAAKYQPELGTTVEELPMNFDGGRGEQARLFWIGPKRTEKVILYFPGGMYMFPVTEMMLKFWRYAQSEWSRQGLEVSVVVLSYSVGSDPDAAFPIQLSQATQALKHLLSIGCKPSDIQIVGDSAGGNLITQLLSHMVHPCPLPSFVPPLHLPPGIRLRGACMISPWVGLSDPDQWGSTLRTKDYDVTVHQNLRQAGEHYINAISNINIPHDLSQLIPYAEPVLAPDDWFLNLQNSVVDRVLVTAGKEERLFDQIEVFFKRKIKPYHSDAILLVQGGGIHDDIIMDFEISETPLRNELTPVVLEWMAEGFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGU3</accession>
    <name>A0AA38JGU3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1074835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGU3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14311">
        <property type="entry name" value="UBA_II_E2_UBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3732319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="211" mass="23547" checksum="D4E734EB37F8C2AE" modified="2024-01-24" version="1">MDARLRRVNKEIADCKNDKTSNISLELIDNSPFHLKGSFPGPEDTPYQGGRFEVDIIIPDSYPFQPVKMKFITKVYHPNVSSASGAICLDILKDAWSPVLTLKSTLISLQSLLCSPEPNDPQDAEQRSFDETARYWTQIYAGGPGKKEAKGLRGVKDEVAIAGLEKAHVDQFEGLGFPRNKVIDVLRRLNYRGANVAQISEDRIVEELLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH50</accession>
    <name>A0AA38JH50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_304013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH50"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="307" mass="34389" checksum="715C054671DAB43B" modified="2024-01-24" version="1">MQRPTLEGVRIRSTRDALQVFYGVATNKLPLITRRLDAEERRAIVAGNVYVWEERGANTETIGIGMERWTDGMGWGPSRVRDDFLFYHQKESDVEDDPLSPITPWAQLLRREPPSRLPRTSYTPHSVETERLVKQTYSVHVSLPADRPRGIVRKWHFTAYFSQEKLSQLRTIDSIQGIGNIPVPDGLFRSARANKARRDTSGSSTAETVSPRLAPYPTAHTGAIMHLSHSQLPIIAPITTTAIAPSSSCSSSGNSSPLSMHTSSTKPPEQLVPLQYLQSNSSPRRDPADEQLLRRFNTMSSRGFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHI4</accession>
    <name>A0AA38JHI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1070194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHI4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="171" mass="19104" checksum="26DF99BA7E28832F" modified="2024-01-24" version="1">MLATSMPSSSNFPAGFSSSAILPSTPVSKSISPDKYRGAVVEDLQLSPAFALPFAEPVSRVIELAYDRDFSHIPVLDKNRRPLGYVEVSKLKQLWESGQANPNDKVSQFMIKFKRTSTEPYTLITPLTSLDELEQFLQTNIFALVTDAERKFVIGVATMHDLEQFVSRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHJ1</accession>
    <name>A0AA38JHJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1083398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHJ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="531"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="692"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="768"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="861"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="861"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3730032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120240" checksum="4CE1918399716AD2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHN6</accession>
    <name>A0AA38JHN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_423656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHN6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="202" mass="21601" checksum="3FB2C18FE0851913" modified="2024-01-24" version="1">MSSYESKIFNLRLLTKAFCFICLLSMSLPPQTNARSLARALSLPATTATVACPVPQGTSTGSAQGTSNHKSTASSSGSQSQPDDARASASGGKTKERSARGYEADITGLDSNFTALITAPNQAKRAVGAAHGMKLWMMVCAKDVEQFAYTKPGLWVKIGGLDLTPSKPTAESWGINYTTMIDMEESVLYIRIHSQILSMKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHU5</accession>
    <name>A0AA38JHU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">beta-glucosidase</fullName>
            <ecNumber evidence="3 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1092131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 6"/>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHU5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="410"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3723517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="852" mass="93867" checksum="C7A59CDFF7F71D5C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI20</accession>
    <name>A0AA38JI20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="267" mass="30850" checksum="C7868422FB485EFA" modified="2024-01-24" version="1">MSTNPNDSETIQQRRERILQAQAARQRAREEEIARQEAEFAAEMERIEAEEKIAREAEEKAAREAEEKRKAEEQRIEEGRRREEERRVAEEKRIAEERKKKQEELVEARKQEEKQRRAEERLAEEAAAAEEEERERASAFAKLVEENKKEKERAAEDLEKRRKHTTKPHRGVDVEIPVPPSGSRRKSFKSKAVISDDSDEEGDGKSKESAPRGVKRKRTIKMIAKGDSNSVPEGESDPIPGQLFCYPRSFEPPFADPRGGSFVYLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI76</accession>
    <name>A0AA38JI76_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Riboflavin aldehyde-forming enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1068595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI76"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041309527" evidence="2">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="137" mass="15005" checksum="06FB2FBC38DDB5C0" modified="2024-01-24" version="1">MVSCVTFFSTLFTMILMAISSPVKTSVELDKRITHAGIGTWFEPGLGNCGNWNTVNDPIIAIPKDLYDENNGSNCGQWIHITDESTGKTVFGRTEDSCPGCASGNLDMSPDVFQQFTSLDVGVLPISWYFMPQGWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIF9</accession>
    <name>A0AA38JIF9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1081526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIF9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37113" checksum="623E156F3C2ABF73" modified="2024-01-24" version="1">MSISSGPSSIQAESVSAVNSLWKLAEKNGHPEEIDEEEEEEEIDQLASEEDLEEDDTTQEVSGSGQRHYHRAPGTTLMPAVKIENILQADGVTGSLSVSKEGLYVLSIATEEFIKRLVQGGHRQANSGRRNAVNYRDMADTTRQYQEFMFLKDIIPYPVSLSEALEMREAVLKDSFGDATPMPFPRSASAPNPTKASSSKPKSRHSAAVNGKEKINGSASGRTESDASVSMGNGNSRGGQVLSWEGPISASNVLDARPWTHWTEPITQETVRLNPDYDMGNRHDPNSASPHSTSSISPQLSASVAPPLETSFRRAYTGPVSSHLQGPAHKPGHTIYDQESPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ81</accession>
    <name>A0AA38JJ81_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_196013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ81"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3733804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="702" mass="78353" checksum="89D4A0798434C3BD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJP3</accession>
    <name>A0AA38JJP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1111351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJP3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1053" mass="110868" checksum="AA955B35359053BD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJS2</accession>
    <name>A0AA38JJS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_297085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJS2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3732523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="284" mass="32577" checksum="9D4631FAC0BE71C3" modified="2024-01-24" version="1">MADLVDSMLDLMRRLPPTRTEENVASLIGICPDYADDLLGSVDQPLQLKIDRGTGREYLACDYNRDGESYRSPWSNEYDPPLEDGTIPTPKLRKLEISANDAFNTYREMYYEGGVSSVYLWDLDDGGFAGVVLLKKTMTPSASSEPSGSWDSIHVFETAERGRQAHYKLTSTVMLQLTIQKKDSVDDNGKREDKEGWKRDGEVTLGGSMTRQTEQDWPIYDSSSHITNTGKMVEEMEIKMRNLLQEVYFGKTRDIIYDLRSLDDLEKTRRQRELQKELVDFIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJV2</accession>
    <name>A0AA38JJV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_250566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="102" mass="11733" checksum="2E0D9D695F8921EA" modified="2024-01-24" version="1">MPFSSLSLSLSLSLTIAYLVTHRHLIINININVNIFFPCSDTPSHFVFHLLLVILICLISLDSVFLFFFLPLVFSSFFLLSVFNIHTTLNAYVYMIYSTCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJZ7</accession>
    <name>A0AA38JJZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1076466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJZ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="158" mass="17863" checksum="98D9409494C48A7C" modified="2024-01-24" version="1">MSTIPFFPYTVFFLYIEPLSALAGAYYAAFKPQDYLRDLSISNAITNPIVPLVTTQMNMALLQLANLYLLFALNEHLVLSSTTSIKTWNRMLFCLLIADFGHLLSMVPLGTDVFWKVWEWNAMVWGSVGFVYIGASMRISFLCGLGLSSPNTRRTKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK41</accession>
    <name>A0AA38JK41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1003877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK41"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3722776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33412" checksum="25975FD85C2EDD63" modified="2024-01-24" version="1">MSARISSRGTSLLRSNVFAPRISTVNRWRYSSTIPTKSPKTLSDFSMEGKVCLVTGAARGLGNEFCRAFVQSGCTTIAIVDLKESEAKEAAKELTELACVNSDLKKEDIKIIGIECDVSSELSVQRAYAETINTFGRVDSVVASAGIVENYAAFDYPFDRIKRLYDINVHGAFFTAREAARNMIPQGGGSIVLVASMSANIINIPQPQTPYNASKAAVRHMASSLAVEWAKKHVRVNVLSPGYMATKLTRTILNHDPELKKTWESLTPMGRIGEPEDLAGAVVFLSSDASRFMTGSEIRVDGGYCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL59</accession>
    <name>A0AA38JL59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_992616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL59"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000661">
        <property type="entry name" value="calmodulin-interacting protein 111 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="284"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="558"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="792" mass="86496" checksum="DC9F16519F595E3A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLA6</accession>
    <name>A0AA38JLA6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1154445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLA6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="278" mass="30344" checksum="70468C01E6327C32" modified="2024-01-24" version="1">MTIPPKSMKDVLKRKIIPKDSERRLQSPTLYLLLGIGEDYVTARTCFDSLYFRPPSISLSLWLRRIQEAPSRIQEAVGVHSGDPWIILGTPKSLYLFPLFGFILSFLLANLAFKKPLCTSTNSKTTQYTNGATSTAAPKPRSTACAANSPSSGAGSGKIYGNLTNAKALLPRPVLILCPPALQQKRLKRLSKAVAQTVSTRLRSPPCPPQSRYLGNWISLHPSPSPSLENLGPGHKRRRSKPKMNEDNAESMEDLATLLGAGIKLVTVNGEDPEDIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLK1</accession>
    <name>A0AA38JLK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_22794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLK1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="368" mass="41515" checksum="2F2672BABB11093E" modified="2024-01-24" version="1">MIEKNRTELSEVCKQRLTLQNNIERLNEALKLQEQAMEKASQEYQDRLTKQEEASERLLSAVLKRAEAAEQGLGELTKEFTKRLGSMEMQLETVHVASSSSNRPSSEVNDKIGQLEADIGRLRERGENLEKRYHEGDLNDAEKRFVNSLMKFSQDVHEKAMVAKENELRRRDNMVTTLQQKVGKLESTLAKCLKDKGKGDNYVVSELKEKSMLNLNMWMSSPLTDIEAPLLASKSPVVKTINVKSDLASSGFPPSQPVQTNSPPTLNTPTFAKLDEDISDFDDIPLPRLGKRNRAASPSNKATQDTSPRPTRRSKPAARKGDESKNQVQAGEKKVMTLLPCVFCHRSKLKLFPLQKAENMKLKARKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLP9</accession>
    <name>A0AA38JLP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1154100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLP9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="39"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="389"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="221"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="80"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3732700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="508" mass="54132" checksum="58914F1C1A672D6E" modified="2024-01-24" version="1">MLHVQKIAQRNSPHRLSQTALRISQSRSCRNFATASEPYEVVVIGGGPGGYVAAIKAAQLGLKNTQTACIEKRGSLGGTCLNVGCIPSKAMLNNSHMFHQAQHDMERRGIDVSGVSLNLSTMLKAKDDAVTGLTKGVEFLFKQNKVDYIKGSASFVSPTTISVALNDGGETQVETKNVVIATGSEVAPFPGGGIEIDEEQIVSSTGALSLQKVPEKMVVIGGGVIGLELGSVWSRLGAEVTVVEFLSGIGGAGIDEEVAKQFQRTLAKQGLKFKLNTKVLSAEKRDGKVILKTEAAKGGKEETFDADVVLVSVGRRPYVTGLNIEAVGVEMDNKGRIVIDDQFNTSVKNIKCIGDVTFGPMLAHKAEEEGIAAVEYIKSGHGHVNYHAIPAVVYTHPEVAWVGKNEQELKAAGVQYSIGKFNFTANSRAKTNLDTDGFVKIITEKETDRIIGVHVIGPNAGEMISEGVLAMEYGASAEDVARTCHAHPTLSEAFKEAAMAAYSKPIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMC3</accession>
    <name>A0AA38JMC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1131529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMC3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="229" mass="26397" checksum="07C92A12635D61E5" modified="2024-01-24" version="1">MSNSRDHTIYLRIGTLSRSTGDRIDKSFEHYDLHQRIAELEDRHLRDQEQIKALQAQLADNHSSGSSGSSSSSPPDSALFQASWEARTNARIKYLCSLNRAGNALCAWHDPRRERRKYPPRHAPLNTLNCGCTYEEALFEESLARHKVGNYLPGNLVRMDPALRNPLLRLLKERYGYRDGDFERDPVTKDWKEEDGHKEGHEYWERLLVSGVHPRRARGDQHHNTTSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMK4</accession>
    <name>A0AA38JMK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_970842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMK4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="184" mass="21416" checksum="97623878A8E6A432" modified="2024-01-24" version="1" fragment="single">SRWNKAVIENILELVAIEKEQYKLEGELGIDVLRAMIWDFIKQAQCSWSSLNVRLTDEGRAETKDQARTRANDYRERRSNDSRLNSRKHQKFVRRRDGVKLVLQESELLSLSNLDRAKYQRAKDVLDKLGVEGQSSEEESDSEPGVLKVTVPHYRRRVVTEMMKDLDLRVKEVTDSVARQSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN70</accession>
    <name>A0AA38JN70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_963489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN70"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="87" mass="9626" checksum="DAFAFCB7A4638658" modified="2024-01-24" version="1" fragment="single">FTPDRDAMTDFQEIEPEPIRAADGRSFTATGKGDMVISFPMKGNAKWTTVTLKDVLYSPNMSYTLISVIKLDRAGCSLQIEDGFCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN79</accession>
    <name>A0AA38JN79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1084685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN79"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="213" mass="22922" checksum="B7B8FB4BB39F5C6B" modified="2024-01-24" version="1">MLMITARYNSRVAPIRESFFYSSMSMTSGLDVNDLSNGESLTAQKIIRTDGEGRIHLAVPTRLLIVPSVAFIVGATIGLVRGGRASSLRFLAENAHRPPRTVKGWYFYNKTKNYRVLLGGMKGAAKESGKLVAISVGWVGIEEGLRALGDPWNEVKEVGAGLGTAALFCGAYRLPLKTSKQTLLLGGLIGTLVKVLDSAKQRLVKSESPVNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP75</accession>
    <name>A0AA38JP75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1067366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="272"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="327" mass="36674" checksum="EC503D995B7089C4" modified="2024-01-24" version="1">MSVNRIIHVSPVDYSGTVRCYTHELEVSRKISQTEGNSNREFYCCSKDPEHRCDFFFWVDQLTAGTPHQPPPMSQTNSSTPSRTSQVPRTPSKMRLDAIEEALAEKKSDPRANGNNQFTTPSTRIRAQKVKTPGQLKRDEEIRRAVEPQSQSTHQSNDANVFQSSQPPPSNYRLTPLSQAQESINHSDEDDFLAALPLTPPTTQRFKRSRDYDSDEESELDFRNSPSKNKGKKKATVAHDSITPSPTASTKDVTDTLGALASLKLSGIIDSLEEFRGQVVNLERQIKALKKGNQAKLEKIQNLESDNHALKSENDNLRGKIRALEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP93</accession>
    <name>A0AA38JP93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1065617</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP93"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="10">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="13">
        <location>
            <begin position="284"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="12">
        <location>
            <begin position="449"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3734000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="613" mass="68870" checksum="44F073271A8C5675" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPD5</accession>
    <name>A0AA38JPD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1069281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="283" mass="31023" checksum="6A683C0FB9381739" modified="2024-01-24" version="1">MRRSQTVRHHTRASMSSTAGNTSQFGSMGAGTGTGQLALHADDLGVLREGDESDADVLRKQLLEKDRECDRLKTTLSLLQSQLSLRPPVEHVQALEREYKDLELLLEGTQRENERCMAEMERMKIREKMLERELSRLAGGNWQDLLDISPAPPATISTLGRSSAFHQRSNTAPTSTRMDSGHSATSSSLNPSHNPTSLLTSSPSISRSTSANVITASPIQESDSQGSGGRTDPVALAAHIDKVRLLIMGMETRLSKREDHLQGMVRRAEGEGRRWEEVGGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPZ6</accession>
    <name>A0AA38JPZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1152123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPZ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="19235" checksum="0D4C40BFF3626D73" modified="2024-01-24" version="1">MVSLHRTIRNMRRVGLREWWRQMQYIGDAKSGVLVGTDQISTNSTASRRFGNRYFENMNGEEEVPGALGVFIFNAYVLLKFVGRQRWVDFAQHEYHASQVPPEWHSWIHHIRKDAPTNDPVIKNLTPPWQTPWVENLTGTRGAFKTYNTVAPKINAWEPKTISRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRE8</accession>
    <name>A0AA38JRE8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRE8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="340" mass="37420" checksum="9D038366908A06BF" modified="2024-01-24" version="1">MTLLKLPNLAALLIFPSLTVLAFHFILGHGDASGFFDKLSAQCPYASSDDAPYRLPYTGIQSIDKTLCGIVVFFHASFGPDVAPFLIYFLASAAPIMGHAYFESSRPNRPLLMAYPVVFFQIMQLMSFGATFSVYWMLFILSGASRLPPSGLKTTVTKAHAQAILFGIFLGLIILTGCMIIMQDPYVTAIWQVFPIVSSVATVSHLLVRPPSRYPDSGFGVVRGFYIASFVLISSMHITLIMSKDIDELKAFMLPSIEVLQSSTSIELQSLNLLQWDATFGFFSAVLGTLWFGRNAKETFTLLAWNILATPLVGPGAAFSASALWRESWLHEDIKTGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRI7</accession>
    <name>A0AA38JRI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1047788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="558"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1166" mass="131117" checksum="48DD6CA8CF247B3E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS06</accession>
    <name>A0AA38JS06_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1181499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="77"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="220"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="412" mass="45942" checksum="C004088B17401FA9" modified="2024-01-24" version="1">MPSALRSLLSIIQKSVDDIEATFEKRGFDFPSLDEPPSERDSIRLEPSVQAATALLTSAAYQLIANVQLPPSYIFNSLFGYYLPSALRAAMETNIVEILREAGPQGMHVREIAKKAQVDPTKLSSILCYLATYHIFREIEPDVYANNRLSSVWDTEKSLEEIKERQDYKGAGQIADHIMTPATAFEDSPERSPLMTALGYDKGSMWSWFEEPSNEMRLRRFGIAMNGVNSLQPPDAILKGFDWASLPEGSVIVDVGGGIGVSSISIVRAFGHLKCIVQDRAMVLKLGTEHCQKLFPDALSSGKIEYHEHDFFDAQPQTSATVFLLKQITHDWSDRYVTRILQRLRVANASTHFADLSMFVHFNAQERTLAHMVELLAGTGWEVIRVYRSDDSGGYLPQIVATPVPSPASVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTA7</accession>
    <name>A0AA38JTA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1059972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTA7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="1">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="85" mass="9445" checksum="6AEF8B0FF55D2648" modified="2024-01-24" version="1">MVDSDNAKEIPQAMLALVSVAIFAALKEWEQGLNESTSCEFVSANFSEQYDLHIMFLGTRILKTDGSGKGKYHALMARLYREAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU06</accession>
    <name>A0AA38JU06_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1047418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="323" mass="36225" checksum="087B2CE78BC4732B" modified="2024-01-24" version="1">MSSDFRTLFDPQTCIRKGLCPITDIRNKGNPLESHSLYFEQHGSGPEKIIFIMGLNSSSFAWLPQVKHLSRIPEYSVLVFDNRGVGNSGTPKGPYTTSGMAEDAIALLDYLGFTEPRSIHVVGLSLGGMISQELAFRIPERIISLTLGVTTAGGHIWNNFPPWKGFNALIRMMFIKDPSQKIPILLDLLYTSPWIDEKAADDPKGRTNREVEFESYARRLEITRPQTLVGALSQMCAGLTHHVSAQRLRHISKSIPKVTIATGDHDHLVSPHNTVYLKTHMEEAEVVIFKDTGHALHYQRPREVNAMLERVFKEGRERVGAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU12</accession>
    <name>A0AA38JU12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1129484</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU12"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041392141" description="Adenylosuccinate synthetase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="27"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="53"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="316"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="348"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="430"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3736310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="441" mass="48261" checksum="4B433C2C8AF1BC23" modified="2024-01-24" version="1">MAHLFDFVVMLGAELLEATVVLGAQWGDEGKGKLVDILSAEFDVCARCAGGNNAGHTIVVPVGPEKVPKTFAFHLLPSGLVNPKCTGLIGSGVVIHLPSFFEELDALQSRGLDCSNRLFISDRAQLVFDFHQIVDGLKEVELGGSSIGTTKKGIGPAYSGKASRSGLRVHHLFDHNTFAQKFRKLVEGRFKRYGNFEYDTEGEIERYKVLSEKLRPYVIDSVVYIHQALSSGKKVLVEGANALMLDIDYGTYPFVTSSSTGIGGVCTGLGIPPKLIGHTIGVIKAYTTRVGGGPFPTEQLNDIGVHLQEVGREYGTTTGRRRRCGWLDLVVMKHSSLINGYDSLNLTKLDVLDDLDEIQIGVKYVVDGQDLPGFPADLEILDKVRVEYVTLPGWKSSIASVTNYEDLPHNCKAYVEYIENFLKVPLRWIGVGPGRESMITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWG4</accession>
    <name>A0AA38JWG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1130808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWG4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="703"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="855"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="901" mass="101844" checksum="799648570509B8A9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYQ7</accession>
    <name>A0AA38JYQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1130291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYQ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3735293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="360" mass="38444" checksum="BFD34FF78892ABA5" modified="2024-01-24" version="1">MLTDYIIPHTQIAAIIEEAGGDLQIRKDHPVKSPEELAPGECLVKLDCSGACHSDLHAAIGDWPVPPRLPLIGGHEGVGIVVAIGKNTVESPVKLGDRVGIKWIANSCLNCEQCRKGREQNCVKALCSGYTVDGTFQEYVVSYVNYVTPIPEGLPSDAAASILCAGVTVYRALKNSQTSLGDWIVIPGAGGGLGHLAVQYARIRGLRVIAIDTGSEKKNLCLKLGAEKWIDFMENKDIVKEVREVTDGLGAHSALVTASSSQGYEQAIEYLRPGGILMCNGLPGSATLSASIFFTVFKSITICGSYVGNRQDAIEAIDIAARGLVKVHFVNRPLADLKDVYNGMINGTIVGRVVLDMSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZ75</accession>
    <name>A0AA38JZ75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_990996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZ75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="486"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65261" checksum="DB0E4E85BE99551E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1N4</accession>
    <name>A0AA38K1N4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_400557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1N4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="116"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3737093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="387" mass="42123" checksum="BB7FFC4346B21ACF" modified="2024-01-24" version="1">MNSVSIARAGLRRAVGARFLATPSVPSTSKATFADTLNSGPSLDDFISGDVPERVVLGNPRGPRLPSYLKTSIPSGSSFNKIKKDLRGLGLHTVCEEARCPNIGDCWGGKEGATEAEGRSAATATIMLMGDTCTRGCRFCSVKTSRAPPPLDPHEPENTAEAISRWGLGYIVLTSVDRDDLADGGAHHFAETIRKIKQKAPHILVEALTGDFAGNMSHVSLVANSGLDVYAHNIETVEELTPFVRDRRATFRQSLQVLEHAKREGVRVTKTSIMLGVGETESQVLDALKELRKVDVDVVTFGQYMRPTKRHMKVDRYVEPSEFDKWKQVAEDLGFLYVASGPLVRSSYKAGEYYIENVLRGKGSEKKANKLAAQEIALGNTFAANVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MT59</accession>
    <name>A0AA38MT59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1132495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MT59"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="530" mass="61178" checksum="E82308446C215710" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTJ9</accession>
    <name>A0AA38MTJ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 containing snare-dependent exocytosis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1155028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTJ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="4">
        <location>
            <begin position="614"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118728" checksum="C764C2720186E2C2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU78</accession>
    <name>A0AA38MU78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1162335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000149">
        <property type="protein sequence ID" value="KAJ3709991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU78"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3709991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="123" mass="14031" checksum="5CA75ADBC0E27125" modified="2024-01-24" version="1">MSRRRPTLKLRALYALRRARATSLADGPGFLYAFVDRGRDWKLGMTSDFDRRKAQWDKECPYEEPDTSNWKSNAWIGLNVIALTVGVLISKSSYFAVIGTGRGESSFDHCFCGLQYSVKLYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUF7</accession>
    <name>A0AA38MUF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP citrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DFJ43DRAFT_1153679</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ET3784</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUF7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="22">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="21">
        <location>
            <begin position="299"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="20">
        <location>
            <begin position="548"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="19">
        <location>
            <begin position="719"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ3732959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1150" mass="124456" checksum="E27DA5555C7062E0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUF9</accession>
    <name>A0AA38MUF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1008812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000116">
        <property type="protein sequence ID" value="KAJ3711654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUF9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="68" mass="8050" checksum="9B3B3AC5BBF76301" modified="2024-01-24" version="1">MHSTQTKYPNDKFDVVWRKVGDGSEWRIKCIDCPGKLYKLGPGETLSNFEVHLKNRQHRHRVDDRIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUV0</accession>
    <name>A0AA38MUV0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUV0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="288" mass="33189" checksum="ABAE69DE2C3845B0" modified="2024-01-24" version="1">MVLLSNTSFALVKDKHISPLNFIQTLALTFTPVQDTKLKVHDGHLSTVLIAFNRHPPLFHFDYPQCHEHSPNKPCRCQRLKEKNEASGAELREYTGDPVRVFLVRGRKLGKVTRRLTPETADKITDAWTIYFGYKSGFTVVRDCADVPLVSPDWPWKVSRLESGNHNTGRFTSTAELLAEISHTTWTREGKDTKNHLQRNLPVKGRFSYLDAVMQYLRAQKFITDADITKWNTRVQAMLKIEQSDEYAAEMKKMKDEALEGQQSKEEEAQTQCPDFDFNHYLNLDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV41</accession>
    <name>A0AA38MV41_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1102642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV41"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="228"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="463" mass="54461" checksum="1A737C70A957177C" modified="2024-01-24" version="1">MIKRLCSLPLEDLGFAPNLEADFIKNPASLLEAMKLPEQKDTTGPPSSEIFDLCQGSSFTFPYKDDQTRTVRLKRVIFRSNSIIGRGTTVIRVECACCNCPPARCDWKEKKLVLKMSFPSKTRVSERTFMDRCKELAQGEYAWVSNHLPDLIWSFDIPFRDGSPQANLGEKFKDYEMRVMRGVILEELKPLSSLKTARECAQVFYDIVQCEFSIYIKRSHFSSNGLSISGHHWVWKYPRILHRDISQGNIMVREKNGKKYGVLNDWDLAIWLDDKRDGPTSQFRTGTKPYMAHEQHSVEWKGPHRYRHDLESIFYVMLLLVCLYSRPDEKLRRYKNQSYQYQEWHQSDDRSLYLEKHHTIRADDWEPPVTTFFFGFLLWLSRLQDSFRSGFIDRGNFHRAVRKTAQLDRSHTQMNFYDEDTLGGHLSYEGIVSIVHVFEEEELETRGREWQLHLDNLRQKQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVG1</accession>
    <name>A0AA38MVG1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1100310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVG1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041457806" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14943" checksum="499F419DEEAF83AB" modified="2024-01-24" version="1">MRRKFAVFLSIMIMLGQGCRNRNFSIQWIRHHYGDYGCCLLFVQRTLHRVSTTALYILYLCTHKLTHAYIPHATLRVSLSMLILACSNFLQTRSLINTMQARLDGQRARTTYACPNLIITRRDSFTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVP0</accession>
    <name>A0AA38MVP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1061402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVP0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="932" mass="104064" checksum="240843091BF9C764" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVS8</accession>
    <name>A0AA38MVS8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1104017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVS8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3714567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="51" mass="5741" checksum="A60D6185330C6730" modified="2024-01-24" version="1" fragment="single">MSDLADTLINAGWDRETLAESEWGDIKDDYKGSGWTASEFVRLRMICNGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWN7</accession>
    <name>A0AA38MWN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1093028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWN7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041204098" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8531" checksum="53DF656279D83B92" modified="2024-01-24" version="1">MHTLVTLDIFSWFSGTFVAAVPSSLNPKIYLMARSCPSAPSSRLQVLAGLAFNASSSHINLFGWTLASISSMHRIFSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWU5</accession>
    <name>A0AA38MWU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide lyase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_730590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWU5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052063">
        <property type="entry name" value="Polysaccharide_Lyase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42970">
        <property type="entry name" value="PECTATE LYASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42970:SF1">
        <property type="entry name" value="PECTATE LYASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041447304" evidence="3">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3720237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="360" mass="37100" checksum="A3E7383B61DD5A16" modified="2024-01-24" version="1">MARIFASLAVFVLPTLASALAFEGAVGFGSIATGGTTSFTVTTLADSGTGSFRDAVSESGRNITFSVSGYIVLESPVSLSSDLTINGQTAPSPGIGVMGREVSASGKTNIIVRNLRMRQGTEETDDGKSAFNMGDASNVILDHCSLEYGVFDTVDAVGAVNVTVSNSIIALPIGQQFGAHLETGPATWYGNLWVSAHNRQPLSKANTQYINNVIYNYQAGYTVADTGGVFSHDIINNYFIAGPSTTSASDDYFQIDDNQSAFATGNLLDSNTDGVLNGAAANTIGSAQVLSSPWASTSLSIAGTLTAAEVYASVIANAGASPRDEVDAFVVSTVQSLGTEGAIITNQDSTGLSNDGYGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX39</accession>
    <name>A0AA38MX39_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1227199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX39"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041421900" evidence="1">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="130" mass="14516" checksum="2885CC8F1E2DD524" modified="2024-01-24" version="1">MRFTLTYLVLGLATAAYAAPTNPPAPQSVEVKFLDNFAGSELSTPLSVIEPEKVQKGLDRIIKKYASKGSSKLPKGWQFRIMNEFNDDDVKGFKCAMKGFGQCVNGYWCHFTVLYDESKPPILYQLVPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX43</accession>
    <name>A0AA38MX43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1089949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX43"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3724944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="893" mass="98351" checksum="D699A455B1FB9402" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXF3</accession>
    <name>A0AA38MXF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_643793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3723544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="336" mass="39053" checksum="A3CD6903E5BC0D56" modified="2024-01-24" version="1">MTFSSLVTLFFLLTTCCLAFARLIGLFFIQCTPLSITISPFRLSKGSRRLAVGETRISFHFPRRNRPQWATISIYNINYRSTSSQHFTIAEASLAVLFPFSILNNTTSRPAPMSLSLDDFRLRIPSSQNTPSWVVALRRNILYTILNEETQRLDQFRLKTIFSTLEMQRRDGSEGNNSEVVKDESRITHHSSQWHIYNRATSRLYQFGRLSAQLRRTWKDDSGTFTLIAEDCHWVRQSHNSEEDSLHFNYSLNYLYDQILTMISFIRRVPAMLHTLYIHPKAIYSISYFVDIHISRTDITFDCFHISDAEPLRHGAELLRRNLQNGLGPMVGIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXN8</accession>
    <name>A0AA38MXN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1157072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXN8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3727232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="277" mass="30910" checksum="E139E7E93FE45A53" modified="2024-01-24" version="1">MNSSLIALDSFPTAVTLSEMPNPSPEEQEVLDRLNLYGVDPLFRVLKEDDLVPTGINPFTEEITVSLDGVVSACLWKSLIDLVKLVFRAGNTAPGGVIRPEYLNVVGMTLPPSFSNIVRFHDSHNPLGYSIPRLQAEWNFYTAQRMLRELVNWISTCQYRCYKFAEAGIDPLWAWTQALTTGVVPPPDTFVFTFGSSYPGTTRTYDPRLPGFDPRLLEYVLPSQEVVLHPIASHYAQHYPGFNAFTRDVLVSVPDSCTGDVSCLGLFGDDLNEIQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXR9</accession>
    <name>A0AA38MXR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1086608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXR9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041346070" description="J domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="466"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3727367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="579" mass="63190" checksum="F66A7B4DCEAFC052" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXY9</accession>
    <name>A0AA38MXY9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1001854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXY9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="160" mass="18001" checksum="5E7B952116A7A068" modified="2024-01-24" version="1" fragment="single">MNEKEEKHSALIKSQTDLNKKSRSDQEIPGEEYGEPPVEGGPKTAEVVEDLVSSKRLLEEVDICKELSADQVDALQQILIRNEEAFGLDGRLGNYPEEVEIPMLPNAKPIALPPIPLSPVNREVVDKQIDSWLKLDVIEPSKSPWAVPVFIVWRKTKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYF2</accession>
    <name>A0AA38MYF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PH domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_599536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYF2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3724308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27682" checksum="ED491C3D7F397FF8" modified="2024-01-24" version="1">MPPNPTTRTRNRSSSNAYVEHEPPPSNWNQYHTPLVNHVSAVHHPGILKTPPLRPASAAKSGAGMSAASRYAHNLKVLRRRDPSILRIFDQFSHVCIYHHNGQSWEKKGFEGSMFLYERADYPPYGFYILNRMGMDDYIQRLWPEDNLSVTGSYLMLRTWPEWSRNRIRDIEALNGSKELHPFDERYKWDQETRPNEGTEVSKTIGLWMFNTDAREPLITVMLRRVYIFRLICSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ49</accession>
    <name>A0AA38MZ49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_498705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ49"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="257" mass="28013" checksum="04179719BAC715AD" modified="2024-01-24" version="1">MTTLPSFVELMASLGINAKDEQPERELECHAPSSSHSSPSSSPKLLGVSTPSLRSKSSPSLRDQSHRSRTRYSPYSSTSIFARRRGSVSSVSSSSSSDMDSISERSSSCSPTLKSSSPRMRKRAHDKYLVNVLGSSPDLSANTPISSYVRRKTPGTSPSSPSFPRETDDSRELSKPFTIPTLPSFLPLSARGEKTFSSSPKSESEDSSSLSNYGLKQTELDVLSRRSRLHTGIRISTAPKITDVGEREIHHRIVHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ96</accession>
    <name>A0AA38MZ96_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_494850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ96"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3729019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="401" mass="43216" checksum="7446F6884462E41B" modified="2024-01-24" version="1">MRVAHTSHALSAFPVYSSAFLSQSELVIGGGGGATKSGIKNKLRVFQVGNDRSIEQKHELELARGEDAPMSMATDGKTIVCGINSASEMLEKGENENCRVFDVDDGKLSFVRAKGTLLVKPDDLDFQKVTVLSFDGSLLAVAGPNDLSLLSYPSLMPVAQSLKLDKEIYDATFMKTKLIVATTADLQVYSLPDTSTNTASPSKSKKKGKQKASTSLPLLVCEHVIDIPSLFGGASGSSFRAARIHPTLDTVLYTVVNTVPSRSRGKSGPRQAHVSKWNTENWTVEKTRKVGDRGITCFSISPDGKLLGYGSSDLSVGLLDATTLNPVSTILKAHEFPPTTLAFNTNSSLLVSGSADNSIRVITLPDQVRGSNWSFFMLIILTLIVLMVAYALQRYSNTFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZB0</accession>
    <name>A0AA38MZB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_376329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZB0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420:SF12">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="229" mass="25538" checksum="8237D3BF64A3C4B8" modified="2024-01-24" version="1">MEYSYSVVPIPTSPLLQAHVDKYASLRLLALRTNPECFFSTQDEEGRFSREQWRGRIDTDDRVTLIAVASRLLADSSPESSSSSSFANTSVSLDSLDGEAAEWVGLITVLTPEFLKERRDNIPPKFQKYAMCFGEPANVLVSMWVHPEHRRKGLGGRLISEAIDWVKKRTVTTKNFDVSNGRLGGAVVLEVVKGNTGAGMLYRAMGFETIDSEDASIWMGKRLDNLPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1H6</accession>
    <name>A0AA38N1H6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1065269</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1H6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="13"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="360"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3733936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="473" mass="51627" checksum="4F664BBF734368B1" modified="2024-01-24" version="1">MPPIFNRPTTDKYDLVIIGGGSGGSGFSRRAASYGKKVAVVEMTAHLGGTCVNVGCVPKKIMWHAADLRERLMYHTSGYKMQGIPEAPKFDWASFKPQRDAYIRKLNGIYHSNFDKEGVEFHQGYGRLKSPKAVEVTLADGQTYTLESDNICIATGGHPTIPSEEVIPGASLGITSDGFFELEEQPKRVAVVGAGYIAVELAGVFNSLGSETHLIIRGETVLRTFDPTLQQVLTPWMEHTGIKIQKSSKVVRVEGEKGKTLTVTLDSGKKIEVDCVLWAIGRHALTQDMGLEEHGVKLDEKGNVVVDEYQNSSIKGITAIGDVQGKALLTPVAIAAGRRLANRLFGPEKFKNDKLSYENIPTVVFTHPTIGTVGLTEPDARKKYGDDQVKIYKSSFRSLYFSMVDEEHKEPSTYKVICVGPEEKVVGIHIIGMGSDEAMQGFGVAVKMGANKQDLDDTVAIHPTSAEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1S0</accession>
    <name>A0AA38N1S0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1070150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1S0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="80" mass="9197" checksum="0DFFDBC3AE70033C" modified="2024-01-24" version="1">MLPWKKNLWCAFALRLETLLKILDSVVVELLFISIITMLSCAPHISVDILKHYFPWNGYSEPKCCMARVGYWNSDGDSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2I3</accession>
    <name>A0AA38N2I3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_204603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2I3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="90"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="512" mass="58223" checksum="151C736BFEA364AF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2Y2</accession>
    <name>A0AA38N2Y2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_993072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2Y2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3734387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="439" mass="46975" checksum="4CD8378D900FE742" modified="2024-01-24" version="1">MPVPEPESASAESQSLTKAQKKAEGRARQEQQRAAKAAQKQQQQSGQNAGSSSNKSKGSTVQKKPASESNKIPSAAASSSKDAPTTREGAVGADGLSDGPKSRGLRIFSHFGLPKTPGHQIKGDIHPAIVKLGLQFSEFKICGANARCIATLTAFKTVIQDYVTPPHNTLSRHLMTHLSPQITHLVTARPMSVTMGNAIRQLKLEISGSDIDLPEQDAKDALCQEIDNYIRDRIIIADEVIEDLAVKKIKDGDVVLTYARSSLVEKILLRAHALNKRFSVIVIDSRPLLEGKTLLHSLTSVIPPIPCTYALLPALPSLITDADIVLLGAHSLHANGSVYSRAGTAMVAMLAKEHSVPVMLCCETYKFSETVMLDGFGKNELAPMKFSPDAPKSNSNLEVLNPLYDSTPASCITAVVTEVGLIPPTSISSIPLALGRTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4K6</accession>
    <name>A0AA38N4K6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1053181</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="244"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3736053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1401" mass="156342" checksum="4AEB09DD0D1ADC6E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5P6</accession>
    <name>A0AA38N5P6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1035179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5P6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3737478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="218" mass="24485" checksum="07A021124C5E3DBD" modified="2024-01-24" version="1">MNKPKIDQSFLPYLESLDHSSRTAAPVHGYPATRMDSPRDPRISALETNQAMSALASVRSAPARQYPSAPYSDHRDSAFISRPVGHGGYDSMYDRSLIGYSGRQHNVDNTREFSSGSNLQSRPMYDQRNLDSSSNMRHRCGVCGKRFSRPSGLKIHITTHTGEKPTAYVCPEEGCHRSFSVRSNMRRHVRIVHQSTMYPEGSTDSSEDGDSRDSREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J312</accession>
    <name>A0AA38J312_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1102015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J312"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40866" checksum="274540EDFBBC461C" modified="2024-01-24" version="1">MESLGQVLKWLLAVLLLLNIRAFPTIWHFRIFRPLIYIWASQFFLKMRTILKSKAAKEKAFERWMDALTPVGATPFHSTVFRSWASFDESDYNFHLSNSSYAKALDAARFKLACQLLPKFLVAGGVVPLAGTHFQFVREIPILAKYEVRVTLEAWDEKWIYIVCRFVSKPKVKSRKSHSPVAKKDGAESSPSFFHAPVNSSGVSMSSTPLTSTSPVPPTDIDKLASKLLATEEPDGATLHTITVSQMCFKMGRITVPPAVVFAVNGLCAPPTSISSSNMDFASDTPYSLANPPPHWDEVKAIASRLHGGSIKKLQAFFRGGWKDVPEGERWWERVMGGGVELRRRHNLEVLDMLRKGMEGAREIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5D1</accession>
    <name>A0AA38J5D1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1125596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5D1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="198"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3719130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="418" mass="45192" checksum="34AE877E5CDF0BB9" modified="2024-01-24" version="1">MAQVWRPDDTEPPVPETPGSEIFRPDILDAIEQKIEEMSKELSDLSLDVHAHPELKYEETRTHDVLTSFMSEHGFQVEKHYLLPTAWLATYKHGQGGRTIGVNSEMDALPGVGHACGHNLIAIAGVAVACAMKAVLEQFNISATIKLLGTPAEEGGGGKVKLLEKGAYEDMAACLMCHPAPGPKGSVSLSGSLAIQQLTVEYFGHTAHAALSPWEGINALDAAVLAYNNISALRQQLKPTARVHGIFEGKDWAVNVIPDYAKYVCNIRAPNVDELDEVVKRISPCFPAAAQATGCEHKITIAEKLMDIHQNKALGEEVARIVKSRYGGIDFVWGIAHASTDFGNITYALPSLHPGFAIPTVPNGGNHTRDFAAAAATPTAHQACLDVSKALAATGIRVLIDDDYFAEVKKTFEERQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J631</accession>
    <name>A0AA38J631_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_567771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J631"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="197" mass="21027" checksum="425884914FD1BAB3" modified="2024-01-24" version="1">MPPLGTMTGMLRAVSEWAAKQKPGINARPGRSTIERRVLGIAREKALVAARAQAGGMNVETENSVGGPLSSNEEGGSLQEDETINDLPPYVPSAETLLPCNGIRDVLITGNTDPRHAAVWGNWVWKGRVRKWDGMVGLVRSANNGPNGISTGNGGGGKIFLYGTILRGRNLVGTWRLAHDPRMPAYEGAFTLGRKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6B3</accession>
    <name>A0AA38J6B3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_114880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000123">
        <property type="protein sequence ID" value="KAJ3711126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6B3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3711126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="137" mass="14574" checksum="1DF435724B58A0B5" modified="2024-01-24" version="1">MSNEPSSSGQQSAQLLYAPNVQHNNLTLTSIRFISAVFAGAVAGILGLTNFAGFGLFAVAMFWSAFCVYVVCCKGKPGKYMTSAVTAKTSNGSSGSGIMELLNPGSDNAFTFVLVWTLFYGEDSMDISYKPQKVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J717</accession>
    <name>A0AA38J717_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_481001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J717"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3729114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="236" mass="26282" checksum="4A40A86C65D40390" modified="2024-01-24" version="1">MEYVISVFLREFWLKQPGNLDMRKNHAGMPAFVFEKYLIHDLPETRTTLFKVSGPPECKPTCFGELDTTDAANPSGKTWGILKLPSKVVYDNSDQVQKPTRTTLRPNRVNPSPLSGFGQEPLEFDFDRATACECLNRFFQPDSVRLALGAVPGSSFEIAPIYEWPMAEKTSSKRFLLHFVLRSDHCGGECTGVVSMSGKVAGNICNVHGQIIYKTDGDKGAHIPVLPDCRVHYTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J828</accession>
    <name>A0AA38J828_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1087087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J828"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="486" mass="54087" checksum="BFD60FC0E8F41EA7" modified="2024-01-24" version="1">MSFLSSSPPAFFAARNVSESPQFNRSINFENNFQSSSSSHQLQMTHNPLDQDEVNMRYIQLKMSFSALENEHKRTKFELETYKELYNQLLHTIQDAPALTSTPTTALLPIPSFQRINFLKVKLWTTQDFFDAKNGNGNRGVSLKGHFPKQTGLWFIEDEFGQPLNSHTTDYVREYAKTVWMLLRERQVKRSLPVPKNWTEANADAVNLYHHYMCHRFPFLALCDDLWKTKQIWLTDYTSWYGKRRDKINLKVEQSVKTEVKDDSLDKDSALSSLIPAKRAQTDTLTTLSLETDNSLVMAPKSPKLPRLKLSFSSAEFLTPSTAIPITPTTAKPSMPVAPATPTTAAESSPVITPPTITTDVPESTELDFAPVSATVADSIPVTAISTLQFPHTPSSPTKASPLQISTSFNATHTVDLNGLFNNPKLAASLLPPPAQVLLSPITLKAPGPLSAIIEHSSKSTSNPKPKIRFGELTVGKFVSYDALFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J861</accession>
    <name>A0AA38J861_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_849661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J861"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="136"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="315"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3715242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="467" mass="50687" checksum="C621EA79F61445E3" modified="2024-01-24" version="1">MNRIVDERTTFLLPLSRSWSRKMIPVRSSLILLAALGKLGSAAPAVSSTSITESVAIPSSTDSAALSVTTVPFASTDPNEPLWNIDSPDSAPSPIRGSLGASIMGPDNIPIDLENPDLFAPPTSDNGDTGNSKWPFALSHNRLQTGGWARQENIEVMPIATAMASVDMRLEAGAIRELHWHKTSEWAYVLKGTSQITAVDTEGRNFIANVRAGDLWFFPPGIPHSIQATGDDPDGTEFLLIFDDGAFSEDSTFLLTDWLAHVPAEVISKNFQVNNSEAFAHIPDKELYIFPSTVPPDDQQAPVSPQGTIPISYMFPLSTVNATQLSGGSVKIVDSTTFPISTTIAAAEVTVEPGAMRELHWHPTMDEWSFFIEGTGRVTVFASQSNARTFNYQAGDIGYVPAAMGHYVENTGNTTLRFLEIFNSDRFQDISLNQWLALTPPSLVKAHLNLDDETIAQLSKTKPTVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8D3</accession>
    <name>A0AA38J8D3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_797275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8D3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3717288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="23583" checksum="E5DE9A61804E4020" modified="2024-01-24" version="1">MSNSLQTHPTTIMTFIAEQERTEGFTHVILITTGSVASVKAPLIVEELLKHARVKVEVVATQPSLTFFNVDHVIKAGSRVWVDQDEWKKDYKIGDPILHIELRRWADIVLVAPCSANTLSKISHGICDNLATSLLRALSPTTPTYVFPAMNTLMYEHPLTSEHLRIVREVVRYSVVGPIGKGLACGDVGLGAMTEWKDIVQIVVDRFQLVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8U6</accession>
    <name>A0AA38J8U6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TATA binding protein-associated phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1000925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8U6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3729071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="145" mass="16167" checksum="8AE426BC3053B93D" modified="2024-01-24" version="1">MSDREGLGASTSDDDLSLPKATVAKMITELLPKDVVCAKETRDLVIECCVEFIHLISSEANDICEKESKKTIAPEHIISALKALGFDQFTSEVEDVLKDHKQQQKDREKKVSKFEQSGKTEEELLAEQEKLFAASRAKFQPPTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8Z3</accession>
    <name>A0AA38J8Z3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1162233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000142">
        <property type="protein sequence ID" value="KAJ3710256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8Z3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="264" mass="29327" checksum="DCFEFF14D5A47741" modified="2024-01-24" version="1">MSLLLKEVSRWEVVKLVGTHDDFNSLDSRMTIFPILRSSRYATPPTDRLKISCSNSTTFSSIPIGVLRNLCLWQRLLRRDSLTGHWDHLTRLELHDTSSENIIDTLRVSPQQIDTPGLTSLKVLPTDKKHYMIIMGCARCRGEFLLQVEFPASGIVSLRAWYLGHAAQKLAGPHQQTLKVLSITETTSGTPGSHTRSLGASLSMSSVASTSSSSLECEVVETLSTVFLQELNPDRPSSSSFLPVLTELNLTRNSGLKFDRRAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9E3</accession>
    <name>A0AA38J9E3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_87650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000116">
        <property type="protein sequence ID" value="KAJ3711659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9E3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="36"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3711659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="186" mass="21083" checksum="1520DBB132FCB1AC" modified="2024-01-24" version="1">MSLSHNRLPPNDEIINQLVAKKLKALLRANKIRLVNPASKIFRPRCDLFDNPPSNLVTAMFELPGVKRSEVALNLREGVLVVAGERFRPEKYMSLSSFPRFPPVSTKAEASTRNELELKSRYVLEELRYGTFERRIQLPEGTQDADINAHMSDGMLIVTWPRQPSCQKSSISAQDLPTLPRNESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9X2</accession>
    <name>A0AA38J9X2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1073016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9X2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041314898" description="Galactose oxidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="786"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="844"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="935"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="956"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1046" mass="111449" checksum="68D1EC5AE18590F4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAG0</accession>
    <name>A0AA38JAG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_284557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAG0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="81943" checksum="34F1FAC7D9D6AF14" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAP7</accession>
    <name>A0AA38JAP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000080">
        <property type="protein sequence ID" value="KAJ3716255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAP7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="838" mass="94826" checksum="295ADAB6CF1A1EB3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB80</accession>
    <name>A0AA38JB80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_805306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB80"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="343" mass="36859" checksum="4F7663633822384A" modified="2024-01-24" version="1">MSSTTSNIVPSKFTALSKPMSSSPNSQETSAHSIHTHHPTTQSPPLPSSSSSPPVLPSKINRSHSSPSSKAAVANIASNFIVKIRRGAHAMGAHRRRASDLSSHSSFSSSDEEKDDDNRSQPTALNTPTKHITGPKTRLNHSTWRCSSGPPLTTSSIAQGQQNKRVEYKDNFVCSGGVNLPLLLRATRASLVEVAESQAGIGVGFRSVKKVVLDNEEWRCKITGPPLQPVSPPSTPTTTSPIPVSKSTSASPYPSSSTKARSLDSSYAFPSPASVTLSPTKTNKNARKYKVHIHYYAYAMIASPANSRTLGRNDYNQPVALERAREGSIRGLMTVLSRSEPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCQ5</accession>
    <name>A0AA38JCQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1108080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000122">
        <property type="protein sequence ID" value="KAJ3711248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCQ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041297911" evidence="2">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="172" mass="18965" checksum="7298FB05602C04D8" modified="2024-01-24" version="1">MYPQFPKILAAGIMFALVLPANASPLHTPISKSAPVADTRSDIERSRNQIIHDLSPPTSASDIAFDIMHVKPQFPNDLYAHIPPHSTRLHKEVSDTNHVIAHSVQVLHASTPLPSNLESIEQPSPPSPLTSTDHHILDYNDESYDSFYRLVGSQDMLAKSEAAGHHQETLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD11</accession>
    <name>A0AA38JD11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1191424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD11"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="249" mass="28148" checksum="C5FA9FE4F0F215A9" modified="2024-01-24" version="1">MALWELESRYNRNARVNTPSSSSSPSSSSSYIQRLTAEQAAIEEQLVEVHGMEVISARLRNTRIGDGGGGAGGISNSPNSIDAKKRALANFGSTAPPSHIGMLGMEEAIAIERRAHLHDLQRKHRLEQKKLDHGYPSRTQVMSREERERRVWAFMNYKPTESDLEDEEEEGEEDEEGGEGEGMDEDEDGEGEEDPSTWFEDDQDDGRKGQNIVEPDEMDDRDMDGLRNVIRVMDPNQLRYGTFYEPRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD69</accession>
    <name>A0AA38JD69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD-P-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1114925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="27544" checksum="4033C5DCD6D37502" modified="2024-01-24" version="1">MALVQDKIVVITGASRGIGRSCAQEFAKHGATGFLLHYYGDAVTEAEIQSLKQEIISGGSQRKVEVVPGDIADPETSSKIVTKAVEAFGRIDVLVSNAGICPFAEFLTMPHATWERTRQVNLDGSFYVTQAVANQMKVQTPQGGAIIGVSSISALVGGEFQVHYTPTKAGILSLMQSCAVALGKYGIRANAVLPGTIATDINKEDLSDTVKREGMIARTCLGRLGQPDDIAGPVVFLASDLAKYITGSSLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDM0</accession>
    <name>A0AA38JDM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1155984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDM0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF129">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE C1773.17C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="66"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="132"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3730864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="340" mass="37677" checksum="FADAB0ED7E64FD32" modified="2024-01-24" version="1">MTLTSDIKPKVLILNAPDKAPIDSVAKLKEMAEFYSIEQASHDAVAGRIAEAVKEKGPFVAFVVFINWWSRPFPWPMDEALVGPLVETGCKMFSAGGAGYDFVDVKYMSSKGIYYANTPKMPALRTADSTAMMILQALRGSSEREADARAGKWFDPSKPLAKDARCSTLGIIGMGNIGKLVSEHMQHFGMKVIYYNRNRLPPDEEKGAEYVSFEDILVRSDVISLHCPLNEDTRHLFNKEVFNRMKDGIIIVNTSRGAVIDENALVEALDSGKVLRAALDVYEFEPQIHPGLIASKHTTLSPHAAVANETFERDQQMEILLNLESFLKTGKPTHVVNDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEW3</accession>
    <name>A0AA38JEW3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1105478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000100">
        <property type="protein sequence ID" value="KAJ3713266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEW3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="77"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="466"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3713266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="63858" checksum="FB53ADF91FDAEC39" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEY3</accession>
    <name>A0AA38JEY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1089538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEY3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="83"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3725038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="575" mass="61684" checksum="FA3BEE67CEB2B625" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF12</accession>
    <name>A0AA38JF12_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1041507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF12"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="219" mass="25206" checksum="DE1476DC559B3DB8" modified="2024-01-24" version="1">MSDTHAQGVMEMKVTSFTANGQDYPTTYTRSNADPKNTEMSHALNQGDVHLNAETNCYWVYDGEWLLQGTEYAFEHPRSKQDHTRCHTWNTQLLEWKIHHTNNSPVASHLKDFTTKLDLDLPSQIQVNGNMCRAGGTVKSVVMQIPFKDKMIWDEFCLSSKGIYEISNKGVIEHMWTIGNVIEHWAGKEYLVNATDPYLNILEIVPRLEQAWKYHSPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF47</accession>
    <name>A0AA38JF47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="6">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF32</name>
        <name evidence="9" type="ORF">DFJ43DRAFT_1098312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF47"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="383"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="928"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="928"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1011"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1106"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3718086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1191" mass="131964" checksum="FDBD909E56B3A148" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFH2</accession>
    <name>A0AA38JFH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1082981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="646"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1223"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1269"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3729959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1403" mass="155600" checksum="0793D1B30BFE2F80" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG33</accession>
    <name>A0AA38JG33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_989640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG33"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="236"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="545" mass="61342" checksum="53F9F5DCD1390C2B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGA0</accession>
    <name>A0AA38JGA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1158654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGA0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="329"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3721312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="592" mass="66126" checksum="6A43BCB88C6CF846" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGV4</accession>
    <name>A0AA38JGV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1114845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGV4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3734739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="533" mass="58777" checksum="BB4D74DA580EF264" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH67</accession>
    <name>A0AA38JH67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_382301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH67"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="258" mass="27468" checksum="8E81CF6207C7D3DF" modified="2024-01-24" version="1">MDSEHSTPTTSLTGKIALVTGSSRGIGAAIAVGLAEQGADLVINYRTDIKAADRTVAKIKSMGRRAIAVQADTSTLCGGKSLLDATVKEFGHIDILVLNAGMMGTHVMEDSDEAYFDAHFNTNVKGPFFLVKAAAKLFPESGGRVIFISSSMTIASQIIPEYTVYTMTKGAIEQMSRLLAKDLGTRSITVNTISPGPTDTELFRSGVSEDLMRYLASQNPNKRMARPDDVAPLVAFVASPAAYWINGANLRANGGYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHJ8</accession>
    <name>A0AA38JHJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isy1-like splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_36648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHJ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="347" mass="39445" checksum="1782BE7176BC9AD2" modified="2024-01-24" version="1">MARNEEKAQSMLYRFREAQAAELGLGTRADRRPRMASACKSLRDCERWRGEILREISRKVSKIQDCTLFVFCNMYHLFTSILAAGLTDYEVRDLNDEINKLMREKRHWENQIVALGGANYRRNVAMLDDDGKEVPGTKGYKYFGRAKDLPGVRELFQSRKIDEDEDNQTLSFYKKFMNQGPAYYGDLDQEDGVLLESERLAEEEEWEEAYTTLREVLGLPEDEPIPQMPRHESSSSTADNSSASAVQSKRKAETDDGASNDSEPSPSDKRLERVTAEATISSSNPANQLQQAFLHAQTAASYIPFLSAESLLPPRMPTRVEMEQVLLDLKKRALVEEYFGNEKSAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHR6</accession>
    <name>A0AA38JHR6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_999010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHR6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="124" mass="14052" checksum="B7E9E5F025AF7449" modified="2024-01-24" version="1" fragment="single">MSDNFFKISSLPKLNDDGSNWHSWKEKASTLISSKVGLYRHLSGRAKKPSAPVEKEGKSYKTADSLIPLSDDDAEAILDKIDVYNQREAEIRNIIDQCISETTLNAIKSKESAFEVWQELCRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHT3</accession>
    <name>A0AA38JHT3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Eisosome component PIL1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHT3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="544" mass="57381" checksum="DF5B201A551D2411" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHW5</accession>
    <name>A0AA38JHW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_250108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041418422" evidence="1">
        <location>
            <begin position="22"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="427" mass="46806" checksum="E4E1124A18D34A74" modified="2024-01-24" version="1">MMLFAVVLGLQYFLLTSRVNATAVFAHFMVQNSYSYGPSDWAADIAAAQAIGIDGFALNTAVDTYEVSKYPDAFAAAEAANFQMFISFDMTYDWAEADMVSLVQTYATSPSYYKWNGNSLVSTFDGDAQDDDFWAGFKSDLANEGVTISLAPAFIDYRDPSEATTMFSTYTSIDGFFNWWSWPADVAADLTTATDLAYQAGISAAGRSGPYIMAVSPWQFKELGGTNDWVEQSDELWKYRWEQAISDVKPDIVEIVTWNDYGESHYISDINPIVNLGDLAPLYVDGFDHGAWRTMAQYYISWYKTGSVPAITEDQVVYWYRAYPKAITCSEGDLPRNSEYPADAVFAFSMLTSPATITLTVGDSSASFDASAGVAIGSVPFSTQDAQTPVISIVRDGTTVKSGTGTKAISTSSCPYYNFNPLVGIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHX2</accession>
    <name>A0AA38JHX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1150037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHX2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="402"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="501" mass="56244" checksum="70DF28582C402079" modified="2024-01-24" version="1">MSGRLTRRNAAEPELSSLTKLDSLILAQSVYELGASSWAEVAKLLSKHPLLQHPKSFFTAQSCETLYKKLRTDASLEITDQDNERHSPLNRKLAQIHYEARILELRDLISIEEQNFKKVLSEIEELKNNVNVGQGNAPKDEAKSDTEDLTSDLSGISTSSSLVNNEPPNKDDAVSENEVMDVQDESKEEMEEVESLAISRDQPTPIPRNQSLEEGNSHQGTVEASIDVEDEGSRSSQAPNPDTNEWKVVPEQDQMEAADEEGVTSGDEPLQRARRAKAAKRQRKASTPLPTRKGRRSRRTPVLETELALETADNISEEVAQTPGTIDGEASPAPDDILFKRQSKRRASFSDDNPREPRRIRADSELADDEDGPPSSSRSRRQDNQASKRFQNVIGMLHSQISAHRNGAIFHNPIKNSEAPDYHEIVKRPMDLKTIKSKIKDGAISNSLEFQRDIYLMFANAMMYNRPGSDVYNMTEDMMLESEGYIQTFRHSEGFVRGSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI87</accession>
    <name>A0AA38JI87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1042912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI87"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041327145" evidence="1">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="173" mass="18831" checksum="ED1B39B9CE090777" modified="2024-01-24" version="1">MQLSNFSYLVLGLFFVAGVHTAPLMAAESNSKLQIRGVGPSKLVNHDGPPPDKIFVQFIGGTKVEPGIVYDSLGVQDTAIEYRVFKALKHFSRGIASQDVHFRNLYDPSNGAPTLECIVIGIESSYLIISIDEDGIPTIRQLRHSDGLIASEYEGVRVIDGVFHPPSSPRSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIG3</accession>
    <name>A0AA38JIG3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_432968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIG3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="90" mass="10006" checksum="02A08384DDB32612" modified="2024-01-24" version="1">MRSSLVRSIQIISRSSLPSRTKFNPPLHQVAKVAAKTVQPTIIDTLTQRKAAGAASWPANLRIEPVVKKGDLKNVHATIRLRLKQMLREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JII8</accession>
    <name>A0AA38JII8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF914-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1077705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JII8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3731833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="388" mass="43830" checksum="CD01287FDF91B13D" modified="2024-01-24" version="1">MSSPMVKDAKDLDYTAPALESQSIIETSTTAKRPPIKFSTPGAFVNSVSARIRSIFTKRFLFSLLAGQIVSLCITCTNVSTTELMLRNWSLPTTQNVFFYFALFATYTPYTIYRYGFRGWLEMVMRDGWKYIILAACDVEGNFMVVKAYEYTDLLSCMLLDAWAIPVCLFFSWIYFRTKYHWTQLLGVFICVLGLGLLVCSDELTDKDYEALSRGKGDALMVAGATLYGFTNATEELFVRKRPLYEVVGQLGMFGFIICVTQAAGLEHNDMHAATWSGANVGLLLAYTSAMFILYTVAPILYRMASSGYYNLSLLSSDFYGLIFGLGLYHYQPYWLYFVAYVIVIIGLITYFWYSAPEDQAELAPAAPTYIQDRREELRGPQKIAGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIP0</accession>
    <name>A0AA38JIP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_347536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIP0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="131" mass="14223" checksum="19B88FE2CBD6761C" modified="2024-01-24" version="1">MITRNLLATSRSRFSATAFLHSSARRAAAAPHTSESYNKDDTDVSPPPDSQIHRVDPNSDAQKPHEAPSGPYSQAGAESAEYKNTDSKYNGDHDTRYGGRKQYMEDKGPETSKSDEGPAGKSAQGRKPEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ87</accession>
    <name>A0AA38JJ87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">chitin deacetylase</fullName>
            <ecNumber evidence="12">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1183905</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="12"/>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ87"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041265905" description="chitin deacetylase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="16">
        <location>
            <begin position="137"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3731750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="415" mass="44994" checksum="9D709D32D506218B" modified="2024-01-24" version="1">MLFPVLFQLGPLLAVIFLQHPPLANTAAIDRTSEQGEASIIDPDQECTPYNYAPVTNQLSSFPPVWGPASILPEDSAALAAWNSISATIPTSIDKKTEPPPSSYSSSDPDCWWTYGQCTTPKLAGLPPDVTAALEPSTLGYGFDDGPNCSHNAFYDFLQSQNQKANWPLEAQRALAEGHEICAHTWSHPYMTTFSSEDAFAELWYAMQMIKLVVGVTPTCWRPPYGDVDDRIRSIAHALGLQTIMWEYDTADASVDGKTITDQTVVNNYNDFIQKAESGAFNLTGTILLTHELNNFTMSEAVSFYPQLKNIFQHLVPVGVSLNKTQPYVETNYSLPTFEQYISGTLTGSRVTPNSTTVLPSSTSSASPLPSVSSSIDSPSPNAATSATKFGYDSVLLAALFVALSCSLQTALTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJS4</accession>
    <name>A0AA38JJS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_998613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJS4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041242981" evidence="10">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="216" mass="25003" checksum="AD4C6002822F15C6" modified="2024-01-24" version="1">MVSNRLSSLLLLLLCSALAANALHFYLDANEKRCFIEELPTDTVVEGHYKALEWSEQQQSYTLDENLGIHVEVEEVETGHTVVKSKGPSDGKFTFTSHDAGDHSICLSTNYTSWFSSTHIRLYLDIVVGTTRPDAEHDRTHVSEIAAKVRDLNQKLEDIRREQQYQREREADYRDLSEMTNTRAVWYSVAQIVVLIVTCVWQLRYLKNFFEDRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK90</accession>
    <name>A0AA38JK90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_151191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK90"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="391" mass="43408" checksum="336E1FDB37569020" modified="2024-01-24" version="1">MNNHNLYDPPVSGRTIGSPRMMSPRSHRTHRSARSARSHHLLHNSDERNGFNGTGEDEIEDDGPLPTAENLHQDDSTFNIDPDAPILGAGGESIQEAIHSEEQRNEIKREKNFVGGFVVGLKRALKPTWNNRQRSDTEAAYGETPYTSDYTSFPARDPAEIAEQQVYPHAESSYHSQPSPSSETMHGTQEFLDDGTTAVDHRTMTMPIPTPSHYVSPELVEPQLAPDYAKMGSPASSTSQVSLNSYMSRIVDFFQHINDLPWVAESRVTVDYYPGQPKRHARSRPPHRKVLSWYNRHAFPPGQNAGFLDLNAGSSPSTASGQALQMTEAQPTLVSKDPEDVVEPLILPTVPVPESQIHSAPTYLAELIHPPPLDRKHNVLRVLGGRWSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKF3</accession>
    <name>A0AA38JKF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amine oxidase</fullName>
            <ecNumber evidence="14">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1000465</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13 14">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="14"/>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="17">
        <location>
            <begin position="138"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="298"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="12">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="13">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3730133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="742" mass="82982" checksum="865AB9BAEC2C9A36" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL44</accession>
    <name>A0AA38JL44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1187547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL44"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="22949" checksum="AB510026CFD6B43B" modified="2024-01-24" version="1">MNTFLTASSWSFFKSLATPIWITQEQAAEFDKASEYRQLLIQSIHVTAIKFSEVAASVVLALMEFLGGSAGSSASDCNRTMAPSRNLNHKNIQTRQGKILSLSPPANDPIPCREVPSFRVPNVHGNFNASKDDDDDHDSLSDDDASSGCSGCLPGVGLRPSRNALAISVFTQQGKDRVCFIAVLLERIQGVSRAHPRQFNAPSMTLRSPTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLC3</accession>
    <name>A0AA38JLC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1154503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLC3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="588"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="110857" checksum="8D591A9B39EE0659" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLF8</accession>
    <name>A0AA38JLF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_299133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLF8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="241" mass="27778" checksum="9115FF1EEAC92BB1" modified="2024-01-24" version="1">MSGFNEDGALSHATPEQIERAFMEKTNDFNEAAFGMYRQTAHVNPTISPAQYNFRQMYKFNNTSNFLHSLSPEMRAWLRRITHKQDDSGAGRQEKLRLAEYRQNVAETRMKKDEANAARRQAAEEEINAVTPILTITELESRLQKGSSKYLTVTDLTLQLKWHRMHSPLNSIPNLGSKRDEKISFLRAAINRHIDPRASGILSTSASAVDDVEEDHPDMIWRITWTIATILRKIIIRNEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM79</accession>
    <name>A0AA38JM79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_992973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM79"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="183" mass="21037" checksum="E6EF370FE4452E2F" modified="2024-01-24" version="1">MSEEERKAKDKADREREAAEQVALPYKWTQLLGEVDVNVPVPKGTRGRNLIVDIQKKRLSVGLKGAQDKILEGELCKEIKKEDSTWTLEDDVILIHLEKLNQQQWWENVLTHHPKIDTTKIEPTDSKLSDLDGETRGMVEKMMFDNQQKQMGKPTSDELKKMEALKKFQAAHPELDFSNAKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMC7</accession>
    <name>A0AA38JMC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_992000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMC7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="305" mass="34966" checksum="86F5BAB84E6D5C43" modified="2024-01-24" version="1" fragment="single">FLDATAQKRVNDFLGYMPISDATAEAFGNGERPGPQGDDLHRFYFGNGWRLHPWNDAVVANIAIKVLGDSAVDTLPSLTAKEVQAAVWDLARQAQVSWKGNKPRPVIDTNGEERMEDESEAEVRNLEQTLHRKQRTRINARKSDKYKTRKRGIAELLNATSEDRVAHRKWRMVQEINDALGNEGQSSEESDREPSRRLPNHAFPLRVTRPHYRHPIAGELLNDLDNSVDKLRETSDHRHVQHRLRRRTTDLSMNSVNKGLPKALYDPLYLRSLTPLKRKQLKPSDTAIPRFSAYVSQVESERMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMW5</accession>
    <name>A0AA38JMW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="321" mass="35611" checksum="9C54CE7C80DC01C0" modified="2024-01-24" version="1">MSPASEPFLSSLSSLSSPSDPEAEDAVEYPAKDPNTAGDRSITSLLKIAFKQSLKRYNLEVKFLGGSWKSFRNAITTNGGASDTQTNQVWFIAFAFVIAQIGTNISANSNIRRGGHIADILHSPLEAFGEQEWFCIIPFCVFGLLELDCWGHGHRVWKGHYRMKDLYDTRRDGWYWYTYGINFSWYFDQRRWIGSDGSDRPSRPTQIYEMSFFTGFGTSMVIYLLLNWAFPVPGGIGEKSASFEEVDISSVWDSAGHGQAKGSDSESGTGNAELDEVGDGSYSLSVYGSKYDGSDNYSLILRTGTVNLNASPSLLHPPSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN54</accession>
    <name>A0AA38JN54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Endoplasmic oxidoreductin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1067573</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN54"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041227634" description="Endoplasmic oxidoreductin" evidence="16">
        <location>
            <begin position="28"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3733535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="60690" checksum="647A22E2433CE301" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPV4</accession>
    <name>A0AA38JPV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1078697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPV4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="276" mass="30260" checksum="C1CFF05C33723B1E" modified="2024-01-24" version="1">MSSSSSNSNSSTDATSLNNSPNAETNSVNSSNTSSNPSSAFTRFLHKAQLITGLGVADAERAKDLEELNLRRCEKMKSELIERSPLIIFMLKHLRLSGCQVPEKNIFCVPCGSPYSSSGSSSSVAVSSSNTQNQTPVPPLHAGAYLPHPHGAIKLCAGHFFSKQHVESTIAHELVHMFDECRFKVDWTNLRHHACSEIRANNLSGDCRWTRELRRGEGIPGFGSGWTKGHQTCIRRRAITSVAANPACPSLAHAERAVNEVWESCFTDTRPFDEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ07</accession>
    <name>A0AA38JQ07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactan 1,3-beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1037681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055240">
        <property type="entry name" value="CBM13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CBM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22704">
        <property type="entry name" value="CBM13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041462461" evidence="5">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="6">
        <location>
            <begin position="319"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="444" mass="47489" checksum="C85731A35EB6EBF6" modified="2024-01-24" version="1">MTVLWLLPLLAATLLTQAAVIVPGASWTDTEGNVIQAHGGGFLKVDSTYYWFGEDKVLDSTLFHAVSCYTSTDLETWTRQNDALSPISGTMISTSDVVERPKVIFNTKNSEYVMWFHSDTSNYGAAMVGVATANTPCGPYTYKGSWKPLGADSRDEGLFLDGTAYLLYASDNNQNFKISMLDTNYYNVTEEVSVLTGATLEAPGVIKRDNVYYLIASHTSGWDPNPNKVFTASSLAGPWSSQVDIAPEDTNTFYSQNAYDMPLGTNGIYMGDRWDVSALGSSTYIWFPLSWASGLPVIVQADVWSVNLAAGTYTVATGTTYEAESGTLGGSAELLTDSSYSGGKAVGYLGNGGTLTINNIVGIGEAQWVSLYYANGDSTWRNTTLSINGGANVVIQQPSSGGGHVIQSVPVKVNLKDGANTLTFSSGQASYAGDLDKVIVYTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR16</accession>
    <name>A0AA38JR16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1049346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR16"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="669" mass="74566" checksum="A2D6335B4476C06E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR52</accession>
    <name>A0AA38JR52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1166637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR52"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="273"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="3">
        <location>
            <begin position="738"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="800" mass="88043" checksum="8D6A4D8D4DA13DCA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRI5</accession>
    <name>A0AA38JRI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_827098</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRI5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="14">
        <location>
            <begin position="167"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="15">
        <location>
            <begin position="389"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3735703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="499" mass="54176" checksum="854638860E98A64A" modified="2024-01-24" version="1">MDPTLNPTVVSAPGKVLIAGGYLVLDPAYPGIVISTSSRFYTVIRPLTPSTTNTIQVRSPQFNASTWKYTLASDPSPKVDAHAENTSKNKFVHLALQNTIALACEVRGITPVLDVLARGLDIAIVGDNDFYSQRAQLTALGLPRSLASLAQIPPFAPQNVTLSEVHKTGLGSSAALITSLVSGLLVHLGVIPSSALLEDEGKDRQLAHNLAQFIHCLAQGKVGSGFDVAAAVFGSHLYTRFDSSVIAPLMGDDSMQPKSLLQVVSPDNTSWNYRIRPFKLPPLTRLMLADVDAGSDTPSLIGKVQNWRKAEPEKANAVWTAIDKLNQSLASTLSRISDFHSQSPGRYASIVKFISTLQPLQWTADPSLPEFETQVASEFHEAHRITLAIRRSMREMGELADAPIEPPEQTKMLDKCCAQAGVIGGGVPGAGGYDAVWVLMCEPEQCWPDQWPRERIEYLWSNYTELDVSPLSAVESMAKGVRLENIDQIKGLKEVTQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRZ6</accession>
    <name>A0AA38JRZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1181318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRZ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="147"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="594" mass="64311" checksum="30A3B9F8EB791060" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSA9</accession>
    <name>A0AA38JSA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1047435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="556"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1051" mass="115497" checksum="1F38C8D00F58FE25" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSY0</accession>
    <name>A0AA38JSY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1151216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSY0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3735520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="471" mass="52007" checksum="CE10E04D892B4936" modified="2024-01-24" version="1">MTHIDNEKSSVVFKDEESDLFIAEPAEERSLRRLVRRLDRRVVPLAMFIYLLCSLDRSNIGNAKVLNDTTGNDLQQTIGLSSEDYTTALMVFLVAYFIFETPSNYMLKAFRPSRWIALLMFSWGAMTMCLGAATSFSSLTAVRFLLGMFEAGLFPGLVYFLTFWYKPNERAIRVALILACATLAGAFGGAIAYGVGKMNGTGGLEGWRWLFILEGIPSCLLAFLVLGLFPDYPETARWLSEEERELATKRLQGLASVGHSKITWEEAKSTLKEWRLYLHYTIYICISVPFSSISLFAPTIVSGLGYTGLDAQLFTVPPYAVAFVVTVTISWLSDKYEKRSIATSACLFIAGIAFIVEGVLAPTAFKARYGVLCIAVSFAFASIPPLLSWLTANLQTTGAATLGVPMNVSMGAIGQIIGVYIYKASEAPGYPTGHFTNAAFALLGSSLALVMRTIYIRWNRKLGSNDREWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTY5</accession>
    <name>A0AA38JTY5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_867052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTY5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="170" mass="19322" checksum="E7A5707FF9DA04DA" modified="2024-01-24" version="1">MSEPTYDLFFTGKDDPRNCVVIGEDTKPVFFSFETFQRDLSTRTIVTRGKDLIASLEWSPGNHLGMVNIGTRQLLMSQLVQPGSSNNVRNFVSSSDGRTYEWRRCYPDTSGYDLFLLPNGIRIAAFRKMNTQTVVGPSHALLQYQFAHDPLLLEALLSLCLFRWIDLHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU54</accession>
    <name>A0AA38JU54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1143645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU54"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="24036" checksum="5C2AF98108B01D2E" modified="2024-01-24" version="1">MLTRPQFDQACKLLVQEYESSRPSFATNALRGWLWTEHPSVSSLGYLSRNSNYLSRHLEPFIHIDSNDNYTEIDEAAAPICIDTEALTSQQYVVYSATFQVPCFYFTMYHSNGAPLSINELLSSTLFRPDILQDADTTTFALTRRNTAFPLLSQGDHPTTGKPCWFLHPCETTIVVEELLKEVEKVADSEDAKLLSWLKMWFVVLGSIIDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUA8</accession>
    <name>A0AA38JUA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_989547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="454"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1840" mass="207625" checksum="8DCF86F7BEA801CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVQ0</accession>
    <name>A0AA38JVQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1150216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVQ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="140" mass="15868" checksum="EB42CD1F2E24C4E8" modified="2024-01-24" version="1">MKFTFVTPEPHWKHEAAEDPEAAAYARSNAFLLIQLSEKYLSLKRPYIVQFTNMSPASSLFAKANGFGFQFGTLNELDEYQSHYKGSVDACEEDCKDPRFSIRQAGFNILISEGSVLQKPTQKNQKDVMGHCVEYLNTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWK9</accession>
    <name>A0AA38JWK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_993742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWK9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="440"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="535" mass="57926" checksum="0F6710780419731E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWU6</accession>
    <name>A0AA38JWU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1046417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWU6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="469" mass="53925" checksum="A5D447DAADE6A0AD" modified="2024-01-24" version="1">MKIYGEKRLMTTEPEHIKAILATQFDNFEKGPVTFDQFHSLLGLGVFNSDGERWKTHRNLTRPFFSRNRISDFDNFERHSEDTISVIKTRLGQGYPIEFQDVVARFTLDSATEFLFGKDVGSLGANLPYPEGSPLANDPSILNHLSNVFVRAFMQGQIQTAFRARFGKMWPLKEIWSDKVLPHRRQVDEFVNPILEERRKQHLAMAATEKAGDDGEGETFLDDLIKHTADNQVIKDELVNILVAGRDTTASLLTFCIYVLTERPDITERLRCEIMEKVGPNARPTYKIISEMKFLRAFINETLRLYPAVPFNGRTTKNPVVFPRTETQPAYYVPAGVKCQYSVFLMHRRADLWGPDVLEFDPDRFLDERLQKYLTPNPFIFLPFNAGPRICLGQQFAYNETSYFLIKFLQAFTDFQIAWDVQPESSRPPVSWKPAPGTTKGRDKVLHAAHLTMNVKEALWVRMKDASTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRE5</accession>
    <name>A0AA38MRE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1207341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRE5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="305" mass="34051" checksum="EF47163DBFBE715E" modified="2024-01-24" version="1">MVHRSADSRLLANLISHEKEYTNQLQSLLNLSHASFNSLSAYAASSPPPASQVILAVAGSLSNVDNALRLYAAAVEEWTKYLKELKDLEDEVGNVMRDREILVTRLLKASKSTPKPSSNRDSLMFSSSPPASSSTLPGPMSANKKLQTAQAELQACEAHLAKKELELDGKRSSAIRDGLRIRFRALGQCGWRWSEIGKEVEVVLGFGEQGSAYYLVVSRLIRFLLPCQYTLNHLQQNSTTVHHPTCHQLLHRNLLPRLGLLLEVLHQSIRQLPTSTQTLKLPRARLLHHHLPCTSQFLRLTRSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSD5</accession>
    <name>A0AA38MSD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1087781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="899" mass="98633" checksum="E512AD98833E06C1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSD7</accession>
    <name>A0AA38MSD7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">N-acetyltransferase ECO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1002300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSD7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="250"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3726377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34956" checksum="4A6AEA5FEF186B19" modified="2024-01-24" version="1">MSSKVKRTYASRSDQFKTDTPTPLPSPFSSASSGKRKWPFDELHSQVASAKRVKGSNSKLKSKQKTLKQLHFCIDQSTVRTCTACKLTYTKGAEDDEALHRAHCARVQRGMEWGKEEERDKASAGVKEIPNRVKLKDGKKGRVICVDATVGGKIGSKLSTLLDTINVALSASALSPEALRASKAYLFLLPAITPNKEKIVGCILAQRIENAMMIASPSSYGSENDATPSSRPLVTVDDSSGLFCYPELLPTALGISRIFVTSAQRRKGIASCLLSAAARTFVHGCVLDPKDGQIAFSQTTGDGLALMKNWGQGGVRIYDEDHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTW8</accession>
    <name>A0AA38MTW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1169154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000124">
        <property type="protein sequence ID" value="KAJ3711100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTW8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="579" mass="64150" checksum="5490D40F26C9D391" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU97</accession>
    <name>A0AA38MU97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_1008280</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000102">
        <property type="protein sequence ID" value="KAJ3713017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18435">
        <property type="entry name" value="BRCT_BRC1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 15 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="370"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="665"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="908"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="782"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="795"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="842"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3713017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1025" mass="116739" checksum="0935161856A8927E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUJ1</accession>
    <name>A0AA38MUJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1069219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUJ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="464" mass="50514" checksum="81B28D8820AAAA38" modified="2024-01-24" version="1">MTFRNARNSFLPLSMSSPTHTRTRSGTQLSEQYIQDSFHSYLKSSLTQAKVERLLDADLLSSAEGDLMITGPALCLYFAALRSTTNPPSVPLPRHNKTYEPTELSAENCPPTFAPFLRVWAHTVPSIQALAPEYQHDLARIICTLEPLSTPLNPNIHGIAADLRAVAIEISQRRSFQDRYAADLQAALDSGNVPSSPGGKKASFVPPPSYEASPPSSLQSSPNTQTLSLPPPSPTYSADYTTDIHDIPSQQPSSHLSPYTPNTGSGWPSRSPSPSILTPSSPAIEFIRETLYAALGDALERQPFLRGMLKRDPPRAYFAAVAYAILDVATTSLTTEGSVVGVLGTQLTLDDCPPPLRRFMLELAAIGRQAAEIQEADDVRAMKYASQGKDIPTSRMERIQQMLIEGVGCSTQHRGEEEGRRSVEGKAVAFTNRLNGLSLALTHLKAFRDRQDQVFKVLAGIGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVF7</accession>
    <name>A0AA38MVF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_876261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVF7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="40"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="454" mass="52486" checksum="6A39E80AC9BCE6B6" modified="2024-01-24" version="1">MSAAHLDKGFAYTVDVAERSIFPDLRKIPRDRYKDMLIATPFLFRVHDELSHVKYSPTDGFIAREYAGESSKTIIDRLDEEIPSDFMAYGIQDSVKSHIRNFFKVQSPDTICPWISTTPQWTWAIGEAIKRKRGYEVKVDDVKVSVIDLRKLLEFEKSVTSNRRLVFYGMELLHLTEQMHDPRATEWTNHPQEILVFGMIPASTIINTISFESLGVPVPGTQLMSSPLPPWFFRGFVNSNGIAWEARRGAEWYSGLKGVRTILLQNFKHWAEEAHEHDGDISRLIETIASVAFRFAEFLVMPKGEFQMAIRMARLEARLLEVNAEGDALAKRLERMELMESSPSVDEFSGTVEKYLEVDGFSREKILKEVKGLWEKLIRMTTNIAVWGLENLDNILWERLRAQILYNASTYAQKMDELELEVRKCEVAYHHHRYSTERSSAKLPTSLRPEFVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVR0</accession>
    <name>A0AA38MVR0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1061903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVR0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="72796" checksum="8F0F22ABBA67F1CB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVW0</accession>
    <name>A0AA38MVW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1159393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVW0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="179" mass="20476" checksum="F0B2712DF646E2B1" modified="2024-01-24" version="1">MWKAQVLAAGGDPDSVPWQHTCHVYDAIDAIDNINVRWTTLDIEYHGPHPPTPPTWMNQKYWVVLWDICQLFHHQMAMKDWDKIFNKVPYQQFNNQQKQVRSNLMSADWAWAQADKISEDANTHGSMFVPFVCGSDKTTVSVTTGHQEYHPFHASPGNLVTPVPDQSTNLPIESIVDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVZ2</accession>
    <name>A0AA38MVZ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp/Glu/hydantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_744861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVZ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="232" mass="24674" checksum="7FDD066F7AAC2F22" modified="2024-01-24" version="1">MTCTRLLVINPNSSKSVTDGLEEVLKPPPQTEISFYTAPKNAPPSINDMVTANLTATACFLDIQEKKLLDQYDGFLVCCFSDHPLTHMLRETTSKPTIGIFEAAITQALLLGKRFGIVTTGTGYNADIHKGVQAFMGGPSQRFAGMVTTGLGVVELREGNRKKIEANMKEYSGKIAREGADVILLGCAGMAGMESLVMQGAAEAIPMAAPVRVVDGAKAGVEMLSGLVRFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVZ5</accession>
    <name>A0AA38MVZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1103172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000088">
        <property type="protein sequence ID" value="KAJ3714887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVZ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3714887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="347" mass="40013" checksum="28DD8753248C5B5B" modified="2024-01-24" version="1">MSNVMAFTIDSHSWGQHPGTQLHQFLNTAWVSFGFKLKKLSLRGHAASFRTIITSKPLLPMVEELFFELIDNPTSDMPQEDADTLVTVFALFINSFSSRLQALIFWAWTSLELSAFFWSLGNFPLLTCFNFQTSFPRTFRDDPSSLSAFLRQHHTRLKILVLRLNKSPLLHAIQTEQPLSEWMLSTFQANHFSHLEELQLYPSALPRGFDALLTCIQLSAETLHTLVVRDRYLDPQDVLRLVYVLPSNIQYLQLNVLEMDVQLYDSLAYRLPRLLSLSLYISKMLPDFPTFLSEMKIRTYTDWRLRNIGVWQNGSMGPYKLMHALANSIPSVDSFWGVGNTDMDMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWA1</accession>
    <name>A0AA38MWA1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YcaC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_869072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWA1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="222" mass="24468" checksum="360BE41DB7A06911" modified="2024-01-24" version="1">MSAPNLTTFERIDKDNAMLLVVDMQIGLFEVVRDYQPDEYKNNILAHAALGKVFNLPTILTTSTQQGPNGPLPKEIIEMHPSAPLIKRQGEVNAWDNADFRAAVKATGKKQVIMAGITTDVCTTFLALSLLEEGYTVFANHEASGAASRRIADEANARMRQAGVHILSMFAIACDLMRNWTYTPGAPQMLPFFDRYFSVYGYLTRGHDAAIESGQILPGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX05</accession>
    <name>A0AA38MX05_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell cycle control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1092172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX05"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3723526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="404" mass="44926" checksum="ED95E0710CCF0DF1" modified="2024-01-24" version="1">MGLFQRKGSETDESSEDKKEKGGWRRPANTAFKQQRLKAWQPILLPKTVLPTFFLIAIIFGPIGGLLIWGSSLVSEMTFDYTDCETLTPSTSNTSLSYVELPSSKYSYHLSSSASKNVDINAPVYAFLNNSANSQDFDVFNQQQCIIQFDVPADLSASVFMYYKLTNFFQNHRRYVKSMDSDQLSGKGGSASHLNSGDCKPLGSLNNISIYPCGLIANSLFNDTYSNPVLLNPSNFEATNVTYNFSSENIAWPGESKKYVSTPIGNGYSSVDEIVPPPNWQKRFPNGYTNDNIPNLATDEHFQNWMRTAGLPTFSKLYGRNDQDAMQKGRYMITVGLNFPVIPYKGTKSIVISTVSWIGGKNPFLGWAYVAAAALFVLLAIAGTAMHLIKPRRLGDMSLLSWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXK1</accession>
    <name>A0AA38MXK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 associated polypeptide p18-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_569099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXK1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="284" mass="30939" checksum="73E0EC1F635EC110" modified="2024-01-24" version="1">MDIDNASPTSQSAVARDKTAPFLIRTFVKIGSFHRLSLFEDATLPTTDEQQIFTWKDATLSEVLTTLRETAPHIPEYRHPLARFAFRTVYADSGNKGRFSQKELGLVYSRDILGEPGTLTSIAPRLLEDADNENREQTEREKAERTLDELRFVPGDFLLLAVLLPKNVTLGSDLSIKGSANAATQNGPGWKAGGDGGWGKPPAPSIGGPGFGRGGGHWRGDSNGRGRGGRSGARGDDRDDRIPPPRSPRRAGGRGWGDRGGRGGRRSPRSRSRSPPRRRGLAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXQ3</accession>
    <name>A0AA38MXQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1225704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3727307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="99" mass="10874" checksum="84CF0BECEA4A6EB1" modified="2024-01-24" version="1">MNFYRNRLFFLLERRSSLETIMKFITALIYGALLLFISADAQTSCHSKDDCSGGDLCCWGPGKSRVVNRDAGNNALPFVSHLLTLAALEETANKCVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXR2</accession>
    <name>A0AA38MXR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1088133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXR2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="411"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="769" mass="83118" checksum="9437A1160A2ABD4B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXR5</accession>
    <name>A0AA38MXR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1087423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXR5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="66"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3726453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="365" mass="40922" checksum="802750208689EDA5" modified="2024-01-24" version="1">MFSDTHHNHHPGDAYYDRIHNFTTRESRDLNTACISPPRQMTDVVYPTGIGLCSLPIRFECGQFAGKIIRSELCEIQKADLGRKYARVDRRPLDPPPVVTLKFFEVLDEAAPERVRELTSEEIEILGLLCTVDLFPIMGAETPLSTPTGRSGHKKSSSSPTTSSSHYGRISYDSHGYTPGSSVHNLPLTSSTMYSANRSGSTSQTTYPGDIVHWGPGQFPISESSKMTDALVGATFVQPQFIDYDGRRTLIFVFSDLAVKNEGTFLLRYRMFDLFSKAEGHKDRIIQAECYGGPFRVYSTKEFPGLRASTELTKLISRYGIRLNIRETERKRRTKGSPTGGTRRGKRKQSSIDDDHEELDGNLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXW2</accession>
    <name>A0AA38MXW2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1049096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXW2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="97"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="861" mass="94823" checksum="DD8F84C3B76A9B34" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY04</accession>
    <name>A0AA38MY04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1157416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY04"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3725680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="17887" checksum="AA04F7A87DDF327F" modified="2024-01-24" version="1">MSFRTSAMRRPNTSAPGDGSRTITITPAPPSEDEGSSNDTAGSTVGALKLRATTRKPKQKVVWREDVVDNEGTGRKSSKICCIYHKPKAYDESSDEDDSDSDSDCPCDHDHAGSRHSHESNGRDREGLQNRNSESSLQHMDHDDPPNNAYEVAPSSSKGKRKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY71</accession>
    <name>A0AA38MY71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1088117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY71"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="665" mass="71305" checksum="BB7A9B3C7C44B7C5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYQ0</accession>
    <name>A0AA38MYQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYQ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="146" mass="16629" checksum="EC7C3B0A331AEC3D" modified="2024-01-24" version="1">MMLNNEGRLEIEKETAKRAEKLRTETERQKQKSDAQRMDIVRRAEQDRLGSEFSGNMKTMTKSKLIDIAFALKVPHKDATVDTLRIRLNAHFDANPALKKEPRYIGLFECTQKSKDPPQEDTTRLPPPPAFQSHPLAMPGTSSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYW3</accession>
    <name>A0AA38MYW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Piwi domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1187564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYW3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="474"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="828" mass="92364" checksum="7CFBE3017ED99A5D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0L0</accession>
    <name>A0AA38N0L0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1224576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0L0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="68"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="255" mass="28373" checksum="C916CC70C3F7F531" modified="2024-01-24" version="1">MSPPEHHHHIHHATQGQAHDYVQANRDFFNSSDYAELDEHPVFVEFSNTIGKSLCEVYPFDPSSTTALDFACGSGLSTRSYAPYVKSVLGVDISQKMLDRYTKQAHDNGLADKMSCVCTELKGEVNELDGVKFDVITCVMAYHHFSSAKEITSMLVRFLKPDGMLLVVDIEAPTPTLSSSSTSESHARPPTTIHGLENLDYVAHQHGFKVEEMKEFFEGAGLVSFDMKHLTHVNFEGRFDVDVFLAKGVKPSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1J3</accession>
    <name>A0AA38N1J3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_300634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1J3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045564">
        <property type="entry name" value="DUF5910"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19287">
        <property type="entry name" value="DUF5910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="272" mass="31369" checksum="3797CB2488AC516A" modified="2024-01-24" version="1">MRHRARELWITSWLLMVTRVARRMFLIFLRARIRIKRSLVHWFRLMRVLFNIMMLAFPLYLSSIGCFALPLPNNHNFEIRGTSVKKFAKAISNVIREKILIGYSFIQDASAETLTASTTSIGEGAVLVHVPSDWFGSTCAVYADKKKFQNVPKLFVDDIHVMTATLPQILQEQSQAPEQKEYATTTSASSLTKETTILFYRMLGSPRGNLQMLIPPYYFKSSQPSNDNRKLDISLKCVPRSQYKATKKFPTGIVEWDKWNVLNWPQELKLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N228</accession>
    <name>A0AA38N228_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_204950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N228"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="413" mass="46245" checksum="A078AA01EF78ED9C" modified="2024-01-24" version="1">MSLVFPPGYAPTLPPPEYSNLRLEGEQTVEFTPRGNASSPVLANITKACSFLTIILKNQNVAEDDPTYGRGSTLQGEIGLKSSASVSSVVVKLKGRLHVSVSDSGSATIPVVSEAIVLWSQDSAHGALCPSILPLSITFPTTFKHGDRIRPIPPSFSEAFFQLPTISARCWYILKVSVYHGRSKMPFWKPSRSYSLHLNYRPRTRPQRPIFHMNRFLTTLKHIPEDWLEIESTMRTRRTASPDLKPISCRFFIPSVGAFGLSDTIPFHIQLSSNLASLRLLFPDHILEPTRPPSVRVFITRQTMVEVNTRKCWRTVTLMEGTVRAVAPPVDAATFIEEDDVYVDWEGEVRVENDKVQYGGFNIGTIMIKDYIVFALTPPNPRSCPLSAHQYSHPIKLVTDIWTDDSTSHPLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2T1</accession>
    <name>A0AA38N2T1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_867468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2T1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="74082" checksum="BA2C6A43F111B34B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2T5</accession>
    <name>A0AA38N2T5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_221148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2T5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="162"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="270" mass="29876" checksum="7BB095A09A7DA8B0" modified="2024-01-24" version="1">MFTMFWGAPPKASYGSHSFANRIFLLFHKSPPRKPSMLTFLSRKLLLKSLGGLCTLGAIFFIAKGIMSLLHKASCGPEPSEQLSPQPLPHYIDLRKRANEEGDAMAKCFQESHEAYARGDGAGAKELSNEGKEHKQKMEQLNKQASDQIYVENNKNSKPGEINLHGLYVKEAIERSDIAIEDAKRRGDTEMHLIVGKGLHSSDGIAKIKPAIEALMQKHQLIAELDPNNAGVLIVQLVGPDEIARRSNRDEGCIVMMLVSAVSLFFTYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2Z3</accession>
    <name>A0AA38N2Z3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1056802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2Z3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="234" mass="26159" checksum="B698AF6710BBECF4" modified="2024-01-24" version="1">MFEIFAFTHVHNGSLPKSSMTIYSLYIYDRHCACVYYHDWHRTRRPKPAVEGGILPAVSQAVLAPVAESNPSTLAPYSSPRNTLTSASGVVVAVNEFNAQSTASPLLQAPPSPVGVSSTGLAFDEEVKLVYGVVFSLRNMVKKLSGRDEQFVSYRTSAYKLHLFETLSGYKFIMLSDPGTESLRFVLRQIYVGPFLEYVVRNPLINMDSKEYGVDNEYFRASVDRMIRGSSFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N340</accession>
    <name>A0AA38N340_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_175786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N340"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="230" mass="25285" checksum="20C2B7BA2A42EA81" modified="2024-01-24" version="1">MDSSQDCCYTQAGQGQDSGEVVTSALPQALPYVWTSHAIERCAYIAQQLQIQAKFCKNCGVCMSCSSAPLSSITLLIDLSSIHQPQRVFCHLQGLSHGTDLYFFIPEKQHVCYLELGLHDGSHSLALGSSTRLGLLNNLSHSGSFARSTIGSRSLKEQLHAIVSKVKFHRSICLSAPHPSSKSVIKWRSTTISNENAIRISAERIGIQYLQLSWSTEFIASSHYFNVASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3H0</accession>
    <name>A0AA38N3H0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_990613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3H0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="178"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3735901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="283" mass="30348" checksum="B23117DB6BDFB025" modified="2024-01-24" version="1">MPPTFFESLIAGGAAGTAVDLLFFPIDTLKTRLQSAQGFARAGGFRGIYKGIGSVGVGSAPGAAAFFCTYDTLKKTLPFPDHLSPVNHVVSASLGEIAACLIRVPTEVIKTRMQTSSYGSGLSSFSAARILWTSEGLRGFYKGFSITVMREIPFTSIQFPLYEVLKSRLSHVLGRKPLYAYEAAICGSIAGGFAAAATTPLDVLKTRVMLDMRVCQNSFLEDPTSPSPTLISRFRMIYVEGGTKALFSGVVPRTMWISAGGAVFLGVYEWVAGGLMNSRHETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3V7</accession>
    <name>A0AA38N3V7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial developmentally regulated MAPK-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1037326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3V7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041340900" evidence="3">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="204" mass="20458" checksum="4058D084A0071A04" modified="2024-01-24" version="1">MRASLAAVALFPAYALATFSISSPSSTEFWVFNTSYVLITCLKISWLTAFSKNDSNSINWTSTAGDPDSFNIDIINLDNATLNGAFSIASGVANNLSFEVTDVTLVPGDNYICQFVNSSNITQVFVNSSTFSVKPAGTTPAPPVSSSAASSSGSSGSATSGTSGSSTASGSAASASTSNGASTLLTTKSAVIAAGVMGLAALAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3Y9</accession>
    <name>A0AA38N3Y9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1052823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3Y9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="590" mass="66317" checksum="F324C105386224C5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N420</accession>
    <name>A0AA38N420_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1052295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
            <topology evidence="1 7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N420"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="78" mass="8636" checksum="B7EDAB035FD13E65" modified="2024-01-24" version="1">MSLSLASRSTARARSVIFRRQLHASHGVRSPHGEYHHLPFAWPHDKKTSFALKLTAYLGFGFAIPFIAGAYQLKKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4B4</accession>
    <name>A0AA38N4B4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_816208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4B4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="171" mass="18967" checksum="C14D213EC9352CFC" modified="2024-01-24" version="1">MSVVDKNPMMESIVEWANINGPKLEKAYKQKGGWEGWAQVELASYLEQVFGGEGVATVSREDYVYNGNDQRSDLLIKTQKENGTYFTNMFELKCESSANSGNFRTKVQADCTKITNGVWNTEFAPCEAWIIAIGVTKTVGDLAVGGKNLAPYYKKIQAGGTQMTLWWGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N511</accession>
    <name>A0AA38N511_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1045142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N511"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="313" mass="34157" checksum="CB69FD24BFF65B71" modified="2024-01-24" version="1">MSGPPSFSAMSLTKTHHSDTYPAISPTKPSLSQAGKTILITGGASGIGFEIARSFVKASASRIIILSRRTSALDIASERLRDEFQSSGTEFLTRQADIGDDSSITSVWDSLNSQNILVHVLVLNGVHATPFGPDTLSMDKEELMKGFDVNVGGNFLMSSKFVKQPLRSTDQQLNLVNLSTAGIQRHPAPSQNPYTTSKAAFAALLGRIADERSVEDVQIISFHPGLLCTEGTVNYFGQKLPRWDKMALPADFAVWAASQEASWLHGRFVWAHWDVDELRADKAISTQLEQEKGFLKVAVQGLGGVSFDSYFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5A9</accession>
    <name>A0AA38N5A9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1050189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5A9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="151"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="173"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="663" mass="73498" checksum="3B93812A4DFEEE2F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5I7</accession>
    <name>A0AA38N5I7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1047387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5I7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="274" mass="30855" checksum="49B8CF48A5130291" modified="2024-01-24" version="1">MVQPDICGQNARVYLEYDRAADIPAKEDGWTRFVCLSDTHSTTHWDDGGRMPRGDVLLHAGDLSSYGTVQRLKKTIDWLGSLEGYGAKIIIAGNHDLWLDKNSEELIVFDEVERTMMLNACQKLMAKPRLKQVGLTYLEFEETTIRDTSRLKEWKIFGSPASPRHSSGAFQYGTKEEAKEINSRIPTHTEILLTHTPPYRTLDKTRKGKYAGCKNLEKRLTSGELQHCRLHVFGHIHEAAGAVIVKAVDGRSERVAVNAAMMHRGKPVVVDLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5J6</accession>
    <name>A0AA38N5J6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1129133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5J6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3736997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="414" mass="45891" checksum="CF44ACE2955CE724" modified="2024-01-24" version="1">MFAPVWSALCYNYKAIPNGRDDRRSRGFAQYSGKPTRYFVKIRPEHLQFIQTEKPGTPPPSKSLVFGHTFTNHMLTIPWSSLEGWGTPKIEPYGPLSLEPSSTVLHYAQTIFEGMKAYRDEHGKVTLFRPDMNMKRMNSSAARVSLPTFDSDALLQLIKKLIHIERDWIPREPGHSLYIRPTMIGTQKFIGIAPPSEALLFVICSPVGPYYPDGFKPIALYATTEYIRAAPGGTGAYKLGANYAPAVMPQKQVAKLGYAQNLWLHGPEHYLTEVGTMNMFVVLKKGDTIELVTPPLDGMILPGVTRDSLLSLARDHISGTYKIPKLPEHFIVSERPITMKEVQEAEASGNLVELFGSGTAAIISPVNRIGYLGKDIHVPTGEDGMGPISRPIWTELVGRQMGTIPSDWSVPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3Y7</accession>
    <name>A0AA38J3Y7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunoreactive mannoprotein MP88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1005763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3Y7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041389955" description="Immunoreactive mannoprotein MP88" evidence="1">
        <location>
            <begin position="18"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="38285" checksum="8813C6E20B169033" modified="2024-01-24" version="1">MLAIATASLLLASSAFAQSTTTFPDGVVATGTMGTTNPPEPTLGTSLNQTSYARLLSVNSVDDWCIFAPPESQDIADSETIEVAWCSQARNDARVIPDGTITGVSLLKTDMYVQIMGYGDLTKINIPSGDWGGELDPHGAYGSGNPIGGNVTTNMTIDGETINVAEWMLYVSYEQFCFRACTWANSTYSAAAMCWHELDEMGCEFVMPGNYNFNGTFETCEADVAYPPGWYVEGVSDGTTSFSSFAQYWTGVVDGVTYTQGDLNTPSTVQSTPSSSNCQTVATISNGIALASLGVSGAATATGSAATATGTATNSGSSSGAAGVSGSSGSTTAAASSSSNAAAPGVRVFQAGMSEGITLLSMISAIAAIAVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6B5</accession>
    <name>A0AA38J6B5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1169068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000122">
        <property type="protein sequence ID" value="KAJ3711239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6B5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3711239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="194" mass="20760" checksum="CB849BD51AEFCA43" modified="2024-01-24" version="1">MPSALILIADGTEEMEFTITYDTLVRAGVTCQSAFVHDDEFVSPVAAKGSRGIRIMPDVYFEPDASGPDKFDALIIPGGAKGAETISKNTSVQALVREYLSKEKLVGMICAGSMAALTSGLPKQPLTSHPSVKTQLESEFSYSEDPVVVSSNLITSRGPGTAFPFAFKLVELLCGTEKRKEVHGPMVFPSGTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6K7</accession>
    <name>A0AA38J6K7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_114733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000123">
        <property type="protein sequence ID" value="KAJ3711124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6K7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3711124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="493" mass="55012" checksum="D48AC881CA126ACF" modified="2024-01-24" version="1">MSLEPTWSPSSWTSKPVAQDVEYPDRQQLSKVLSKLGTLPPLVTPSEIERLRYQLSLVQRNEAFLLHAGDCAESFDACTNENISAKIGLILSFSLILIWGARLPIVRIGRIAGQYAKPRSSKTEKVGDREVLSFRGDNVNGLDIDDRTPDPERLLRAYFHSATTLNYVRGLLTSGFASLHQPRDWSLSHVRSPSLRNEFENIVEGLTDALDFSRTIGQDSGASFEHGGARSTVGEVDFYTSHEGLMLDYEQALTRECPVPKSVSSILDEKAYYNTSAHFLWIGDRTRQLDGGHVEYFRGIKNPIGIKVGPSMKDDELVRLLDIVNPDKVSGKVTLITRYGAGKVENYLPAHIKAVKLSQHPVVWICDPMHGNTLTSSTGLKTRHFHTIIDELTSCIRIHSECDSRLGGVSLEFTGELNDEGFSVTECLGGSMELSEEQLGLRYQSFCDPRLNFEQSLDVAFLISKHYKDERRGKQKGTEKDVLFTELSGKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6T8</accession>
    <name>A0AA38J6T8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1161533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000111">
        <property type="protein sequence ID" value="KAJ3712130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6T8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3712130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="170" mass="19475" checksum="14AA72704E8A2336" modified="2024-01-24" version="1">MPQSRKALPQASVHFTVKGFRISSSNTQATINVVTVASRPPQDHSQVRLPLVEYGFEGWPQRQQCIHDLDVVHKGKRFRVFFQRHQHLGWNSTLAVRGDLVIMRVGKKNVKNVVNFRSGDAKCARLIARRFVSEFLSSLPIAEPDFVRFAPRLAWFQGRPGRRLESVMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6Z1</accession>
    <name>A0AA38J6Z1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_499995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6Z1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041415131" evidence="1">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="127" mass="13203" checksum="848730B0A47D36B9" modified="2024-01-24" version="1">MSIMPRASNIFAAVMVDLLLVKSLLTLALGAGVPATILAAPSMADTLLKSVKATDVVEKRSSSECTNVNTGTSIGYYRYSADNTTCAGSTIANNSTLTSNSTVTTNASVSLGWIEKTPLGLVKRILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7Q8</accession>
    <name>A0AA38J7Q8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1161103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000098">
        <property type="protein sequence ID" value="KAJ3713480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7Q8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="184" mass="19891" checksum="FA3C3D1D7B4B8328" modified="2024-01-24" version="1">MSFALPPGLYEIHTLIDDKKKLLSPSSPGEKVTIGTIKDPRSVWQISGDGLITSFSTGCQTQTMNSPSTAGSDVVTDKGLGMRWIVCGVESNGNYTWTGSIMTNDVTGLFWSIESGYKIVLASPNFECIPQFRFVPVSLKTSSNTNVTVRPTIGRGTLEAILTLTILILYKILERLGGKAKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7S7</accession>
    <name>A0AA38J7S7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small monomeric GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1007134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000083">
        <property type="protein sequence ID" value="KAJ3715626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7S7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3715626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="186" mass="20583" checksum="F3B4613F8C8E7444" modified="2024-01-24" version="1">MGLSISSLFSSLSSLVRWSKDQDVRILMLGLDSAGKTTILYRLQIGEVVSTIPSAISVAIGFNVETVQYKNIKFQVWDLGGQSSIRPYWRCYFPNTSAIIYVIDSSDHARLPTSRSELLTMLSEEELKGVPLLVFCNKQDVEDALKPEVISEELGLAGGEKSRPWSVRGSCATKGEGLEEGLDWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7V3</accession>
    <name>A0AA38J7V3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">endopeptidase La</fullName>
            <ecNumber evidence="7">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1040762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7V3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="10">
        <location>
            <begin position="798"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="901"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3729148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1012" mass="110090" checksum="50D50F66B3BFE5A5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8K6</accession>
    <name>A0AA38J8K6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil phosphoribosyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1006955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000080">
        <property type="protein sequence ID" value="KAJ3716237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8K6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF20">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="459"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="656" mass="73862" checksum="CDF8D2C3735E59FE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J953</accession>
    <name>A0AA38J953_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide lyase family 14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1097211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J953"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="1">
        <location>
            <begin position="85"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="311" mass="33910" checksum="C4D921A47CA5EF28" modified="2024-01-24" version="1">MMQPWSPPTSINPLVLVPHFQYGFSTSTSANTSLSLSIVNLSDKALGVHKISSRTAHPLVSPPSLNTPTRSLECHDLPPPILAWEAFYPKGSINPSAAIPGGFGFYLNGPKEFSDILRGSESSSGANEIVMSYRLMLQSDWGWVKGGKLPGVFGGVGDLAYGCSGGRKDNRESCFDVRLMWSSKGAGELYVYLPSTEQNRERLLAVPPLSHENADYGFSVGRGAFSIPVGQWMSIAIRVKLNTVGHEDGEIELWIDGISVISVTKLNLRQSEKSRLKGMHFQTFFGGNKPDWASPRDQRAWFADVTGVSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9K9</accession>
    <name>A0AA38J9K9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UbiA prenyltransferase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1106457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000110">
        <property type="protein sequence ID" value="KAJ3712325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9K9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3712325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="315" mass="35006" checksum="E5BD16698E7F5E11" modified="2024-01-24" version="1">MSKRLANLLAPPSKEEFNACWDLCRLNNHMGCWTTWIPTAWALAMVYHAHPEIPGSVALLWAAKYLVLCSGIKSLIMTIDDILDHDIDAMVSRTKSRAIPRGSISLDRAWLFFGMQVVLGVYLAQALLDPISCRFAAAAAPLFVIYPTCKRWMYFAPVTLGLMFTVGVFMGWSTLSPTREIPYEILVPVYIAGCFWVWTYETIYQHMDKADDVKIGIRSSALLCGQYTIPVCSTTAIVFFGLLAYGGFLNGHSYLFFAGVLLAAFLLISKLLRTNIDRPADCRDFFLQTPLIGQILVGGFVADAVVARISNGIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB06</accession>
    <name>A0AA38JB06_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1160216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000080">
        <property type="protein sequence ID" value="KAJ3716247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3716247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="353" mass="38446" checksum="3381F281AB405E0D" modified="2024-01-24" version="1">MTLALRPSSVSTLSLNTTKIPYVVTETEKFNKSQDSNLSINDSTNDDDLPDGEFRAWVVLFGTMCIAFTTSGYMSTWGVFQAHYEQSVLKELSPSTIAWIGSIQQSCLYIPTLIFAQFLDIKYFHTMLATASLVFIVATFLIAQCNAYWQFLLLQGILTGTITAGVFTAPITTILSQWFLRRRGLALGLYAAGSSMGGTILPIIARALIPLIGGMSRIISGLVADRFGAINLMIPAICLSTTTYYVWPFVHSQLGLIFLSVLYGVSIGPFASLVSKPVLDFGEKDQLGQRVGILMSMVGIAMLTGTPISGAVNTYTSPRTLGMGLFAGTVAIEVPFPCPKFVKQEARCFLEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBV7</accession>
    <name>A0AA38JBV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1042383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBV7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="266"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3721361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="481" mass="52117" checksum="D4D600FDC34177A2" modified="2024-01-24" version="1">MGPKTEDGHTTGCFEGFKLRFSRKSPATRTLSTFRSGLAPSKPSEKMLAPSQHFDFGVPSGWGLSSEQSSLDSFLPPYTTQMNASRTSGVVDSVAGKTINSVLDELEPELYQLSMDIHDHPEIAFQERYARDTLTAFMRRHKFNVTSEYLGLETAWRAEYSYGNGGKVIGINSEMDALERIGHACGHNLIAASGCGIAVALKAALETHDIPGRIILLGTPAEEGGGGKIILLQRGAYDDMDFCLMSHPGPGPLHSFDIGATTAVQTFEVEYLGKGAHAGAAPWEGINALDAAFLAYSSLSVLRQQMKPTHRSHGIVQGRDWISNVIPDNARLRWQVRAPTYDEMSILAQRVRKCFEAAALATGCSVNIDEEPPYQDLKNNPILARIFGQIVQTQYGQNVSTNGSAASTDFGNVSYYLPALHPLYTIPTEPHGGNHTPAFTKASATKEAHAASMIATRGLALTALCVLQDDALFLEVRNSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCM2</accession>
    <name>A0AA38JCM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1003960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCM2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="896"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1129" mass="123311" checksum="48EF09AA100BE059" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD19</accession>
    <name>A0AA38JD19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1107040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000113">
        <property type="protein sequence ID" value="KAJ3711885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD19"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041257168" evidence="1">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="201" mass="22727" checksum="A152665209EB560A" modified="2024-01-24" version="1">MHLRLGVWMTALVLGLMHPILGIPTGQRMRIEQDPSSPGKILNAGRYIKQAFVLFQSTEPSHSAHQTLNLADPDVRAAKMMVEFLLESAWKELDIEPLIRWSVREAYAVKLPEIVIRDYAPLAPGWTPAKELNFLLDRIRTKKSAQFPRVDNPGTAYVKPIPGEEGTYEICVEGLVKQTVNIGSETLKELRKLVPFEWAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDX8</accession>
    <name>A0AA38JDX8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_447545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDX8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="297" mass="32246" checksum="BDDB013F711A4E0A" modified="2024-01-24" version="1">MTALPPPTKDQAFCNVSALESGHLNLPLPIFLDNAAPGSAILAPSLSFLLHHSKTDKKLVFDLGIRKDIENAPPSVQKWIVAASFHTSVPQDVTESLTHGGLSPSDVDTVCISHCHWDHTGDTKPFVNSEFIVGAASASFFKPGYPEDPDSPFASDLLPQGRTRFVELHEHPPLGPFPHALDLYSDGSLYIVDAAGHLPGHLLLIARTSADGAWILLGGDSAHHWNLITGESKIADGRPGFPSGCAHLDKEAAELTIHRIREFWKLPRTRVILAHDEPWYKENKGGAAFWPGHIASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEB7</accession>
    <name>A0AA38JEB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydantoinase B/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1106892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000111">
        <property type="protein sequence ID" value="KAJ3712128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEB7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3712128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="589" mass="63667" checksum="C71DAADC8FD5F2CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEL6</accession>
    <name>A0AA38JEL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1133168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEL6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3727303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="600" mass="65136" checksum="9E4F722528FBFCDF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF50</accession>
    <name>A0AA38JF50_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1134317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF50"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="425"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="547" mass="58627" checksum="823A6A0F5E5140FD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF69</accession>
    <name>A0AA38JF69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1225345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041286163" evidence="4">
        <location>
            <begin position="24"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="100"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3729104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="366" mass="40444" checksum="1FE02C00A362C0BA" modified="2024-01-24" version="1">MPPLQVVFIAAMNLLFLNQHVEARRIHWHDTGNGSIALEEAWSIPELGLSTAAPPLGQTSAELNANLLDIFDQRLAHMDATGVDFMVLSCASPCIQGISDPATAESMAIHVNNELAAQISSPSAGNNTGRFGAFAALSMHNASTAAVELKRTVQQLGFLGALVNDYQQSGKDNDTLLFYDQPEYDIFWSTVIELDVPVYFHPRVNVAPISTLLYTQAPWLRGAGQEFAVTLSNHVLGLCTNGVFDRFPSLKVIVGHMGERIPSDLDRIDKEIARQKVLGMPMLRNVSSYFTTNIWTTSSGSFSTALLEYHQQEIGLDRIMYSIDYPFETMEDGEVFLDELEDGVLTEKELKQFTRDTAIALLKLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFJ2</accession>
    <name>A0AA38JFJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chs5p-Arf1p-binding proteins-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1096864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="795" mass="88205" checksum="94293C97C20F4C38" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG11</accession>
    <name>A0AA38JG11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1025785</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="215"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="1922"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="797"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1333"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1396"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1534"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1433"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1443"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1462"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1487"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1549"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1605"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1692"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1738"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1814"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1831"/>
            <end position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3731869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2286" mass="254949" checksum="9A9926D60F1CD071" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG22</accession>
    <name>A0AA38JG22_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1086348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG22"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="475" mass="50566" checksum="E5D75828ACE346B3" modified="2024-01-24" version="1">MSTSLTQPLNAAIQDHYIVKVTNLPPPQSLAPYEAEIQNTQISPFLTFSGKDRIANVFQKVLSESSEHMLDPSDIAIALKAFGSKAFLDKLSPTGAADQLIAWLGGVQCPLPEDRLENLVRLVVNGTAGVFKRDRKKRQLEGSLGSGLTMPVPGGKDIIRTNEKDSKVSGLSKGEKRPLGDSVKGFSKKRATGIKGIFGSTGIQPTSHSRRSQIRGPPQNSHRHAVYFDNDVSATHSSSRQLPTDSNVPAINQASSPDASESPSSVDAQMLASTRTGVSLAPQSAPGRPSSIRSSALDTNDIEDLSSIRPNIQSPAITSDSAHSSHLDSVENGVKLQVSMPTASSVSTLPKRAVEPENLDIAGAKTAAAGSQDFFPESTSTAFNETQHVAITTGSPEISLLPTGPEESRQNSSTSYSTMDSVAFPAPSTSNGNLPRDSFNSGDSSSSTNVQPLVFNITYNHTHHHHHVHNHYHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG82</accession>
    <name>A0AA38JG82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1059439</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG82"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="163"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3735356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="436" mass="48677" checksum="206F8A0E38EE61BC" modified="2024-01-24" version="1">MANSNSLDRAIELVQKAIDEDVKQNYDVAYKQYMNSLDYFMLALKYEKNEKSKLLIRTKINEYLSRTETLKEHITAQNEKRGKSAMGVNGGSTGIGPSGRQKEDGDDPEMKKLRDSLAGAIISEKPNVRWDDVAGLEGAKASLKEAVILPLKFPHLFTGKRTPWRGILLYGPPGTGKSYLAKAVATEAKSTFYSISSSDLVSKWQGESERLVKQLFQLARESKPSIIFIDEIDALTGTRNESESEGSRRIKTEFLVQMNGVGHDDTGVLVLGATNIPWQLDNAIKRRFEKRIYIPLPGPDARRRMFELHVGSTPCQLGPKDYRVLADHTEGYSGSDIAIVVRDALMQPVRKLLSATHFKEIPDPDNTSVLKWTPCSPGDPEAEEKSWENIESDELIEPPLKLADFMKSLETNKSTCTAADIQKHEDWTRESGNDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGB4</accession>
    <name>A0AA38JGB4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1132503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGB4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="737" mass="84996" checksum="219D01CBC087E988" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGD6</accession>
    <name>A0AA38JGD6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_838271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000081">
        <property type="protein sequence ID" value="KAJ3715950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGD6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="174"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3715950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="330" mass="36460" checksum="7CA915A63A65C979" modified="2024-01-24" version="1">MPSAQEFSVLSFGAKSCPKEVIQALEANPADANVILPFLKKSLEGGSSTMCSSDQVWLFCVSRNNGIVTVDMVLSCTENEMGKYPIFIVPTQPVSRWSPTSLSVRLKALAEALRDSVPQERVYSIFAPDIVVFLFSQLWSDLVGIGINEKPYYAARLLSCATVIPNPLPLPPSATCRLAVTADTTAIAKLCKGFSDESEPFVLGRNEAFKEASLLISKQQVWVYCVSEEITCIAAFTRNTLNMATITKVYTRPSCRGRGYARHLVREVTRHLLRSGRREVVLYVAHNNASAARVYESVGFVEPDPAVEVGHSVKWTEVGFDRNYVDLGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH05</accession>
    <name>A0AA38JH05_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_669661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH05"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3722145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="161" mass="18472" checksum="A01485323F854D4B" modified="2024-01-24" version="1">MLTGLEVATLRVVVTKLISELSTDQLNKKSDEILFDQKLADLMGVLFELNAKQALKNNERWEKACTIRASIIAVKGSRFTLFRYMSSRTVYSLAKSYQKQVEQDTATAKMKAYMEKQKVCVYALVVHEVLCIMEPFYISQNKEYGEYSHQRSRNKGGILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHB5</accession>
    <name>A0AA38JHB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1006643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHB5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="89734" checksum="AF437A0814491DBC" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHM4</accession>
    <name>A0AA38JHM4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHM4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="19859" checksum="F6F111E6B1B2EFE6" modified="2024-01-24" version="1">MNAEKKAARKQQNKDRTNRKAKFERRQAIASVMIEVHEKKGDVQGLQFWREVLEAVDILTIGGMSDEEEVTEENERVRLVKDLDFRHPDFRELFRRVDNVRTRNPSIFRNIGRKRMRRVYVLEMTSRQPPPNMPSSYYRQEYLDSMNQGEVPNVKFQKDLDFTIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIP4</accession>
    <name>A0AA38JIP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1111510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIP4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="585" mass="62516" checksum="10CBBE88A5A7D77C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIU2</accession>
    <name>A0AA38JIU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1044900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIU2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="176"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="388" mass="44867" checksum="DD42E31E8CCE4846" modified="2024-01-24" version="1">MPKLHLKRTPEEEAARRLRKKEKKEAKRRRKEDHYGDNSSSSKRRHRTAAAAEESTDRKWDSYDDDDDDDVNEFIGPIPGPSNHQSDYETLHAELEEQRFREKIAMAFEDDERLDSIEARFNCFAHVPVHWGGRIDSKPRINYDNDEFLAMDPMSMDDEEYAEWIRVGMYRKSHAQEIAEKERLKAERAARRAHEKAVRAETERLEKLAAAERRSRRQEKENQRLELSRSEYHNRWKVLLSNTSADMPQAEIGFDDIPWPILPAFKKSDKKSASDNALSLSLDDFTRGEISTFLFTSSVPSADSSIDTAIGKTNSPSSSSTSAQRLAETEMAKARKDRKEKLRETLLRFHPDKFEGRLMSRVRPDEKVKVTEALAIVVRVLNDLMGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIV9</accession>
    <name>A0AA38JIV9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1040037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIV9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="538" mass="57900" checksum="F95BD6AA257F9F4D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIY0</accession>
    <name>A0AA38JIY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1135317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIY0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="134" mass="13517" checksum="3E0970587E1B6B7C" modified="2024-01-24" version="1">MKFFTCVSFFLLLMTGTTTVNAVASTATGACSRLHKFTFKVNVGDTCNFWDHKGHVVDGTCQKREGVHIFRKLTCVQAGGNSTSGASSPSATPSSAAVLPSSTASTDTSGTSSTGDGTGSDGTGSDGMGSDGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ09</accession>
    <name>A0AA38JJ09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1069438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ09"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="467" mass="53496" checksum="4263E9FAF756A6A4" modified="2024-01-24" version="1">MTTETTQPFYFWPARQRDRLSTNFIPDTVELDSHNNIPAFSLFQKIRDHPTGNFQGGSFMVVFDVSENKEIFENLYDYKAPLNLSLIKQAPMLTHVDIPSTSKPLFFVAIDNYVVAISSSFARSIPTFPMAPSNPPEVVEVFPGATGPPMMLNGKECDRETIVSRVDSALDVVLKMVRSKACPEDLHSNNIASLPTLLIKSPSWLQSFGRHISKRREITTSGFHHVWEAVRLKQHKKLRTEIPNLFVLNDGPVLDSSTDQSETTRSEEVACYVTLINRPIVEDWTENAFSELFGRILNQAMRERRHGVRIITGRNETLFDNYGIPRKVAEDSELTWYAFKPDASLFRGHEPYLVVEFESASCSPKYQEDHIRLRLYGGILVRWMCRISGRHFILPALYVWTNGQCDLLFLYEDEGQVRIGIDFTFHICSYSLSQRGDDGGKTERKLRQKRTDTDPNDKVIFIINTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKF4</accession>
    <name>A0AA38JKF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1067824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKF4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="846" mass="94865" checksum="1EFDB024EB3E7F47" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLG6</accession>
    <name>A0AA38JLG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1073241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLG6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="219" mass="24779" checksum="AA3F9591737A7645" modified="2024-01-24" version="1">MLTVHHLNNSRSQRILWLLEELEVPYEIKKYYRLPSMLAPPELLAVNPLGKAPVITDGEINIAESGAIIEYIIEKYGQGKISTSPEGAIDDLYFLHYAEGTLMPILVQKLIFSLIPARSPWLIRWFLKIIFDELARKMVEPALKKNVDMIESHLVKKDWLAGGSGPTAADFSMSMSLEILQQEKIAHPATVAYVKRLQARPAYRRALMKGGEYSYGPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLH7</accession>
    <name>A0AA38JLH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1180493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLH7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44131" checksum="BA2377D354057C83" modified="2024-01-24" version="1">MSQVESDSTGNPLALVNVVSDLLLIIFIHGFKGDNDTFGKFPERLQHVLTETVPNSTVECIIFPVYENEAVVRFSDWLTELTVTKEVAHGGGAGKAKIVLCGHSMGGLLAADSIIEFFRTRPDTSAPLWPKIIACISFDTPYYGLHPYVFKNTATKAAQYANAAKSVGSAIWSSFTNNNPANGTGRTPIAAITAPPTSEAGWSKWAPVAYTVGGVVTAAAAAGGAAYWRRDDLGVGYSWATDHMKYVRNLWDEEALKMRVNSLIEIEKTEGVTFRNFYTLLPAVPLVHNLDRTFMILPNTDKRAMDHFLPAINNTATDELQAHTGMFAAHSNDGYYKLGLEAAGLVREALMLSRGSLEPEAPVDPELEKEEKRTAEMEKEKEVEEEKQKKMSATEDLENASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM14</accession>
    <name>A0AA38JM14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1037805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM14"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="380" mass="43134" checksum="7D4D6D0A31A750EC" modified="2024-01-24" version="1">MSSSLQHPNDDSAASRRPQSFSSYSPMSTNLQHLDDGSAAPVEEMETQENETSVWDTRSSPRGWGYADRGWPGLWGSSPANNQNPESYITRSAALCNLRSDFNAADLSFKGRRTRNMSLDNLETKVWASVQVYRCSGEARRGFASFPTFTGPQILQRLEEVQTQLTSRINEQQSLTHQLRKATDALLALQARGKKAQSEIDALQDTQRELEYLKEIAYAMLIHSLSSQPLRAPSTPQQRELTMSSSQKSQGRCKFDVSLAELSRPEKQTHHYKTYKPPDLPSKAASKSHSEELTPQQEACKRYEERNLLQRRKKARERKPNIILILGLSDAERRTAKKNEKFRKLTKNCIAKDIEKSVGTRRIDAVLLWRKEFPSLFAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM55</accession>
    <name>A0AA38JM55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_267065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM55"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="67"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3732935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="239" mass="26670" checksum="E980F8D6B433F08D" modified="2024-01-24" version="1">MFTQTWNREHYSFSDGFPQAQRENYHPLPQPPSQPPYQPAPPPIPTESKPTLNSSPSTPEPPGGLKIVHLPRDCLNRFLTIAKVNTARNRETCGLLLGKDRGSKYVVTTLLIPKQHSTSDTCTMDEEELILQVTEERGLITLGWIHTHPSQSCFMSSVDLHTHSAFQRMLPESFAVVCAPTSVPNFGIFRLTDPPGLGLILACNAKEAFHPHPDSPIYTDAERGHVQMKDISLEIVDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM88</accession>
    <name>A0AA38JM88_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1174293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM88"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32879" checksum="EB931855479920A5" modified="2024-01-24" version="1">MSDQSSQRYYASKQYLLPADNAETKRLEVQHNMIAGVLGGRLSVAPTNLTTGDRVLESAAGSGIWALEFFQKNYADDIVLNIECIDISPAQFPTSHPPEIHFSVKSVVDLPDPEWTDIFTYAHQRLLITAMNDSLWRSAVSELFRVVRPGGWVELVELEAQDFNSWSVGPYSTRLASLINTMYRAKGVIGDLSVYLPAILKEAGFMDMKCEKMRASIGGDADATPHKVTDVKGYDSEMWRELWIGLKGPVVEAGGYGFIETAEEYEALVEGSVVECKASKEAYTTFFAILARKPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM91</accession>
    <name>A0AA38JM91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1058767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM91"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="188"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3735214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="537" mass="59123" checksum="A658BCA1376E3703" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPY9</accession>
    <name>A0AA38JPY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">DFJ43DRAFT_122572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPY9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="284" mass="30766" checksum="DA858C2657EDBCA6" modified="2024-01-24" version="1">MSIPKTSWADDVDELVSGQQEDDSIRTVVEYSVNEQGKKVKITRKIKRTLQKSIVEHQVAERQKWEKFGAEKGNARGPDRATTTVGENVYLTLSAGNKSAESEQQEEKKPIKSTTGGKVVCRLCKGDHFTAKCPYRDTLGPLETSGDTGAGPDDDTIPPPDAAPGAGPTGSKYIPPSLRAGARGAGETMRGPGGGTRDDLPTLRVTNISEDTQENDLRDLFGHFGRVARVYVGRDRDTGAGKGFAFVSFEDRAVAQKAMEKVNGKGYDNLILSVQWSQPRADPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQN4</accession>
    <name>A0AA38JQN4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1061378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQN4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041263555" evidence="2">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="168" mass="16539" checksum="9F13EAFC0D17380D" modified="2024-01-24" version="1">MFKLALSLVASVLLAQCASGEPVRLEDRQILSTITSDFGDVTSAVVSIATAGASDVTSAFGVGTSDAASAFSDLTSFGDGVFETVTSVGGSLVTIVTSEGGKAITLAGSAIGSAAETVTSFAGHEFTIAASEATASSNAGLTQYESGPILASILTLVVGATFGAFIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRG8</accession>
    <name>A0AA38JRG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multi protein bridging factor 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1035604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRG8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000018">
        <property type="entry name" value="Multiprotein bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="147" mass="15698" checksum="9849935DDD4538EC" modified="2024-01-24" version="1">MSEWDAQVVIGSKRQTPKVTKKDSDLNAARRSGAVVATDKKTSSGANKARQGTDHQKIAKLDRENEVAPPTKVAPSVGRAMAAARGDLKLTQKELAQKVNEKPSVMQEYESGKAIPSPQILGKLERALGVKLRGSNIGEKLGGPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRK4</accession>
    <name>A0AA38JRK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1059086</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRK4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="566"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="754"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="144"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1189"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="194"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3735275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1258" mass="140469" checksum="82C6E82C33AF24F9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS96</accession>
    <name>A0AA38JS96_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1036705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3736003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS96"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="309" mass="35104" checksum="DFFBA7D6EB9734F5" modified="2024-01-24" version="1">MVKRGVVTFLFQAEEQFETITRLEAHGSVGSIGSYNQRYIANNEVKAVWFNYRFHRTIASGGYPRTPRGLGQDTNPWGNEGGWIQERYPGRESNHVWIVESGDDNLEARWHGEITCMVDSNDDGLEGETREQGGCVLKNNGTRYFAVVDGGDDGGIGNTEAGVAKQPTNNGPFVIAPSFIYRAILCKQIYRAILCKQVDAYKGSVVRSREIGRDCVGNKFSFFQDRHSNSMEFQQDTARKRRQTQRKNRFISDEAQDDQEEGIEYEEFEMEDLVTRTMKMRVSGTAEWNTRPGWTGSKVVQIQTTYTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSC7</accession>
    <name>A0AA38JSC7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S1/P1 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1128970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSC7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF29">
        <property type="entry name" value="S1_P1 NUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041422923" evidence="8">
        <location>
            <begin position="18"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3737389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="393" mass="44482" checksum="A47908AF427D4147" modified="2024-01-24" version="1">MKLKLLALALFVPRVSGWGAAGHEIVATIAQIHLHPSVLPVICEIFNYTSTNPNEPPCHLAPVSTWADRFKYRMRWSAPLHYVGAKDDYPSETCVFPGEHGWAGSKNINVLAGIKNVTSLLDAWVEGQRSSDDTAEEALKFLIHFVGDLHMPLHLTGRDRGGNSIKVRFDGRQTNLHSAWDGLLIAKTLRNVPKKYDHQLPIPSLEWNLRGAIYDGFIRQIMWEGILHEWKDQVPEWLACPSEGDTQSSFTEGYWYSFSTFYDHVAHFWYYISSYFKTVSATTDDSTVCPHFWAAPIHAMNCDFIWPKALDEPPYSHLRSFGSDSDSEYLTPRPKSPLLELDTPQYSGYIAENRILEKLMAQGGIRLAGILNWLFADLAEADTDVQDQVPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSD0</accession>
    <name>A0AA38JSD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1035449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSD0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="171" mass="20084" checksum="333EE88855820AB6" modified="2024-01-24" version="1">MPPTPSKENSPSDDEERVEELHLQKKQEERERREAERRAEEEEEAAAEARLAEIQRKKEEKKKREAEERRKEEEANRKREEDEKQKRKEEEEKKKREEEEEANRAKSIASNGDPEADDPNPGDDGEDSDAESDKYKEEKESEDDEDSEKSPTPTPTPNPTPRKASKTWLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSS5</accession>
    <name>A0AA38JSS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_613974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSS5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="930" mass="101227" checksum="7188B7071BF348DF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTY7</accession>
    <name>A0AA38JTY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1136392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTY7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="61189" checksum="E151EB096C7C177F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUT8</accession>
    <name>A0AA38JUT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_226380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUT8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="157"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="593" mass="67213" checksum="A357F12623142B73" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWB9</accession>
    <name>A0AA38JWB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1148698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWB9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="317" mass="35382" checksum="D40E31C9FC7D2E7C" modified="2024-01-24" version="1">MSSSLDTPGRKLRDEQIRLAMHDNPGQAKRRAIISQVLMESEALVQTQRNLLQHEVQRRMAEELFHNLDLQVQDNVDELTQQVNEVNIHAAELKRVVATCTPFSTPTRNRVLVSPSPSTPIRSPVLSPTRPVSPLSMPILTQAGTAVTPSRPPPGTTLREEDEDKASKGDPICPGSRSPAYVVYIGNEGKHGVFYAWSTHKDIIGAFTIYKPTCHTHVICSFSNRQLAHQFYDEFLDSGVAELLAENKPTQDERFIVVEGVAPAAYKNRKSLIMDGLQFRGGVVYRYIGSIEAARSQFNKYKAQGLTQCTHARRTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXD0</accession>
    <name>A0AA38JXD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="9">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1047391</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXD0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="11">
        <location>
            <begin position="384"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3737331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="565" mass="62938" checksum="50BE2241D8A4264D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXQ5</accession>
    <name>A0AA38JXQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1061387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXQ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="298" mass="32852" checksum="E1C119BFCB4289D0" modified="2024-01-24" version="1">MVVRVAILDDYQQVALTTADWSSIADQIQVDVFTDTLSDVDSLAKRLEPYEIICAMRERTKFLPLLLDRLPNLRLIATTGNGGNSTVEHIWTLIMSVARHIVLEHINIRTSNPQWQTVVPMGLAGSTLGLIGVGRLGSETAKIAKVFGMKVIGWSPHLTPERAEAQGVEFIASKQELLSRSDIVSLHLVLSESTTKIINAADLDLMKASSFLINTSRGPLIDEAALVEALKNKKIAGAGLDVFEQEPLPLDHPLRFLDNVTLSPHNGYINETSYKVFWTSTVENIKGYLDGKPRSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYN8</accession>
    <name>A0AA38JYN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1058790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYN8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="82528" checksum="314E988643EF180E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K0H4</accession>
    <name>A0AA38K0H4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SVP1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1150200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K0H4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="448" mass="49594" checksum="FEBAD8A0A45F04B4" modified="2024-01-24" version="1">MNLARHSITATNPVHIFDTRLDTDCEIFTTCSPAGFAVYKAWPLQLLRKRELSGGTLAAAMPMHTSSLLFLLGGGRSPLYPLNKVILWDDAIGGEVAELEFRERVRGLACRRGWLAVSLRRRVVVFEIGRQVTRYQEWDTCDNPRGLVTLASGTHATLLAIPGRQMGHVQLIHLPPCSPPPLTGPPPLTPPRKPPPPPEKYPVSIIAAHTTALSTLSVPPSGRLLATTSSRGTLVRIWDSLTGKLVRELRRGTDKAEIFGVAFRPDEQELCVWSDKGTVHLFTLLSAVSNRQSTFSPLVPYIPLPKYFESEWSYAQYRIPTQSSHISLSATTSSRSSTEDIPDEERCVVGWIKVPGEASMPSEYQLIALTYAGGWYRLSVPKANSTASASITPSLTPRSHGRSTSISSTRSERSYSNKGKEKEKSKDPNASRCKLQEFRRYGRWDGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQT6</accession>
    <name>A0AA38MQT6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1160811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQT6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041276214" evidence="4">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="49"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3714549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="314" mass="34564" checksum="984D38F7423BFA5E" modified="2024-01-24" version="1">MPALTHKICPIFLFLSFTLLSFGFCSPYARPTEVPASKNASSYQTIQHSNYSNASESIHGRGNSDRHCRPFYTTFSDPSTVADSNTNPSNSPFVALSPPETYAITSNGLEMYLQRPKGEVHSANGMNDNLGEAATINSTFWMDSGKVTYEVSCDYVPGVVCAFILIDAVQVSDGEMHLDEIDVELVGSGSARWQTNIFKPSKADPEPHYGHFDTKEQYPQNPSYTSFHKYSISWDSEKIVWGVDGQDARTMRKEDTYINGVPHFPGESDSLRLQLGIWDGSGAEGTSTWAGGPVNWDTTPQKIVATVRSVSVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS87</accession>
    <name>A0AA38MS87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_591252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS87"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="20"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3724942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="551" mass="62253" checksum="179CFA83D8ED0FD6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSW7</accession>
    <name>A0AA38MSW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_456473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSW7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="289"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="440"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3730904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="689" mass="75889" checksum="C41ADA36106F7EAF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSW8</accession>
    <name>A0AA38MSW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1000263</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSW8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="15">
        <location>
            <begin position="29"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="14">
        <location>
            <begin position="315"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3730919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="506" mass="56592" checksum="B6219429F368BC63" modified="2024-01-24" version="1">MSKSKESTSGATAASSFNTTPRGQDDPYQYQTGFGNRFASEAIPGVLPNGQNMPQKNKYDLYTEGMTGASFVAPRADNLNAWLHRIRPSVAHQGFTKLPDNPTLMYTFNPHYQLESNFLPLNSKVHVSPTQLAWHPFDIPSDQVFDFVDGLKTVAGNGDPTLHEGIAVHMYLANASMGRKAFCNTDGDMLILPERGRLDIQTEFGRLMVRPGELIVIQRGIKFKVKLPDGPSRGYIQEIFGSHYTLPELGPLGGHGLANARDFEHPLASFDLDQNHWDSMWCLVCGEMHSCSQEHTPFDVVAWHGNYVPYKYDMKKFVFVGSISKDHIDPSIFCVLTAKSKATNVPLADFLIFSGRWDVGEGTFRPPYYHRNSSTEFMGMIYGEYGGRSDGFKPGGASFETGFCPHGVSYEEFQKATEAELRPTRVHENTLVFMFESSMMWTITDWAMNRSGKLHKHEPKMWDNLKGQFMNHLEEVEEDLKKAGLPGLGRGSEQVSTNGHGQANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU29</accession>
    <name>A0AA38MU29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1180079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU29"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38075" checksum="EA1F0798388423E2" modified="2024-01-24" version="1">MSSNDSRSNSPSDEEEKAELLLIQKKKEEREERARREAKQRKAEEEAEAAAEARLAEICRKKEEKKREAKEKKRKEELERRKAEEEAKAAEAAKKMAEEAKRNEERRKAEEALKAAEAASMKAEMERRLNTVALVRAQLEKKKKEIQVQSPVSEGSTVVAGKKRKRVTMVVVPSGDPEGGDPNPGDDDDYIESDTDDDEDPEVPPTSPPKQSRCSRCILKASKCELVGPGSASCKGCRKAKVRCSLVPDDYPRRSKRVKVESPVASTSSQVIDDLRTNVRDLNTRINLQEEMLRYLILRVRKLEEANREEDEEEEESEEDRVKRTGDRKGKGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUB0</accession>
    <name>A0AA38MUB0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1008195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000100">
        <property type="protein sequence ID" value="KAJ3713259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUB0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3713259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="293" mass="31226" checksum="C578D18087664D82" modified="2024-01-24" version="1">MTPSAYSAPVMDSRSTFKEDIFLGKVLFCTGGGSGICKGMTEAIMRHGANAAIIGRNLDRLTQASKELAEKTGKVCIPLQADVRQPQTLRDAVRKAIEKFGRIDFVICGAAGNFMSPIAALSENAFRTVIEIDTLGTYNTVKATISHVREAKGAYIHVSATLHYRGTPYQIHVSAAKAGVDAISNVIAVEEGPHGVRSNVLAPGFTTGTEGMRVMTGKKTNKAEGFSNPLGRFTEIQDVANAAVYLFSPAACYLTGQVIPIDGGAEHLRGDFFPYPSSVINPSSVETLLKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUF3</accession>
    <name>A0AA38MUF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_88539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000117">
        <property type="protein sequence ID" value="KAJ3711624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3711624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="145" mass="16167" checksum="70604EAFA778DE97" modified="2024-01-24" version="1">MTIMKATFCPRTQSVLSLNHDSELYGHDAEHFNPGRFLDADGKLKSSIEDTRDEGHFSYGFGKRICVGRHVANNSLFIHIAYLLWAFNIVAEVDSNGKPELPDPLQCIEGLTIRPVPFHCNITPRSKDVAEVITQAKVERIGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUL6</accession>
    <name>A0AA38MUL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1106111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000106">
        <property type="protein sequence ID" value="KAJ3712753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUL6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="454" mass="50251" checksum="2E1B16CEB1DAB5D6" modified="2024-01-24" version="1">MLFLRKHAEEPALTEKRFQGFVSDPGNRQLIDQWSSLAYWEGPKLTFARVLYNLWQTDPNRLHFRDNLFSEQQLDTAMALREMALVWDIEPDLQEESEDVKEKPKKEFIQAGGFDSSSMLKSGPLEPFPSVQSLASPWPPTCRLMSLPGPNEASPKYAPQAQEITFTSKKSPFAYLEWHKLIDEGIINGKVASNLRSLSVHLAGATITGGESDIAAGQKSMNSIIVPRAHGIVSESESLTQSPNLIQVVPDAEEVSFVSLFLKYHSLSCQTDILLLTPSNKVNVCRDSVQHPNNETSDVPTAEEAQVAFLEENVRIYHAPVEAHSEEIENISSPSTHTLVGHKSAGLGKEARLSNVTHRSVKREFRQLVRVAGPTAASQDSTKPLTIRIPPVTAQDPANFHHNGRPSSPLTPVLQQTSPRPPLNSKKTVSLAPLSIHRRSARIAANNERTFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUR4</accession>
    <name>A0AA38MUR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_982998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUR4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="91" mass="10290" checksum="9EC0D89F18AC392E" modified="2024-01-24" version="1" fragment="single">DPQAAQRDIFFSLSYNPRSTPQAILDDLWIALPSLRELLNSDEGWGLVLQETWLIVFETVSEPEIMDFSLSLLTAAAVIEGLVYALVHHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUS9</accession>
    <name>A0AA38MUS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1106590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000110">
        <property type="protein sequence ID" value="KAJ3712338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUS9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="128"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="326" mass="37264" checksum="BD91649AC6750B3A" modified="2024-01-24" version="1">MINFSITNGRFKLFTGFLSLSTPQFELKCKETYCLSTLSLSSTHPSLQADSFCQSLMPPLFKLQISSFVFDAPQVQHLEDTTSSSISSFSANVSQDHNIVEPSSSALKMTAKRYTLGFSGDNTFGLTLLFAHGVGSHKEQWEPTIERIFLTQAAKHRHQQIREAWSFDWQNHGDTALVNEEALKDRPEGVSIYVWASAITDFVRSPRMAGHRIVPLGHSAGAGAMMLTMRSFPLSRLPYVSLILVEPTMITREMFEAHFDDRIRSMEMLVGATEVRRDVWPDREEAFRWLSRRFPFRTWDPRVVRLLVVGLTRNMVFTRNHQSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV49</accession>
    <name>A0AA38MV49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1213099</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV49"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041483919" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3715292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="792" mass="86884" checksum="4D7329980AB7DADD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVF3</accession>
    <name>A0AA38MVF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1007646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="381"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="483"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="563"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="599"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3714598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="741" mass="80596" checksum="3AEA69E388D56E99" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVG8</accession>
    <name>A0AA38MVG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_804628</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVG8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="66"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="256"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="446"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3716795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="507" mass="56872" checksum="D2A4F85E4C4831A6" modified="2024-01-24" version="1">MANSAQTSTWKSTLNPPPRDLRPQTSDVTGTSLNIDFEDMGLPRALLMGIFEAGFERPSPIQEAAIPTALSGRDILARAKNGTGKTAAFIIPLLSKINVLKPYIQGIVLVPTRELALQIASVTKTLSKHMGVEVMVTTGGTTLKDDILRLQQPVHVLVGTPGRILDLAGKGVADLGKGCGVFVMDEADKLLSPEFGPVMESLLGYLPKRKEQDAENAGRQVMLFSATFPMIVKDFKDKHMQNPYEINLMDELTLKGVTQYYAYVEERQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHAKMLQSHRNRVFHDFRSGTCRNLVCSDLLTRGIDIQAVNVVINFDFPKNSETYLHRIGRSGRFGHLGLAINLVTYEDRFNLDRIERELGTEIGPIPREVDRGLYVAPSSTEEEQAIQVQRETDQKETALRQQQQQLQQRNTREQLPHQIQHQAALREQAQAQAQREAHLRALQLQQQQQQQQQMTSAASNGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVP4</accession>
    <name>A0AA38MVP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_992871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVP4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="172"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="287"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3734789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="549" mass="62180" checksum="62FC939CE12C7BF4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW19</accession>
    <name>A0AA38MW19_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_733155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW19"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3719623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="184" mass="21625" checksum="DEE99A3A7B7EAE85" modified="2024-01-24" version="1">MSQVYGFRAKIDYEAPPKDNLNWPWVVENETKRLQKFSQLEVVSLQDRQTSSGKIPRGPLDVQRDLFHHVETKLAFQGHFHFISAAVHFLHEQQYIQDLPQDFDALLKPLLAEEKANLASFYEKEVRGLYADEHTNKEELVRWELHRLLENNCETYKRNLDPKLPPADLVHLIEYSQVWCVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW24</accession>
    <name>A0AA38MW24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1007325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW24"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="585"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="706"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3715279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119569" checksum="1CDAF1F84F72341F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWD5</accession>
    <name>A0AA38MWD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoadenosine phosphosulphate reductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1134366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3718053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="271" mass="30436" checksum="D5E3A73C1B132386" modified="2024-01-24" version="1">MLSMPMLPLTPEVLANINAHLSQLQPEQILDWAVEYLPNLYQTTAFGLTGLVALDMLSKSTSSPPPLIFIDTLYHFKETYDLVEEVKAKYQTPLHVYRPAGCDTVEDFETKYGQRLWERDEDTYDFVVKVEPAQRAYAELGVQAVITGRRASQGGDRALLKPLEVDSTGLLKLNPLFEWTFPIVEWYITENDVPCNRLLSQGYRSVGDWHSTVKVGEGQDERAGRWAGREKTECGLHKDYFTMQKQAMKASASCTSSFDLPGTRSSSAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWS4</accession>
    <name>A0AA38MWS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_732393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWS4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="205"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="458" mass="53872" checksum="B8A9346EFAAC66B2" modified="2024-01-24" version="1">MCGTSFLYFYISVRIYLKPPSQLLSVNNQPVFAEMIKYLAADSIRNEKLPEPKLPVVTTAKESPIFELCEGSFFTFPYEDEQTRTVCLKRVIFRSTNVFGRGTTVIRVECACRHCLPNQCNWHGKELVLKLTFPSETHVSEWMFIDRCKELAQGEHAWVLDHLPNIYWSFDIPFHDDSPQDDFKKEVEDGDKMRVLRGSIQEELKPLSSLKTAKECTQVFCDIIQCHHWVRKCAQISHRAVSEGNFMVRERDGKKYGVLNDWDLAIWINNEHDEPTSLIRSGTRPYMAHEQQSVHWKGPHRYRHDLESIFYVMLLLACLYSDPNEKVPHFEDKEFRFEEWHRKDDEFLRRAKISVVHAAPFRPPVSPFFIGFRLWSTRLQERLLLGFVHLKIHITQAAMQEARQPNKLPTFDMETLGGHFSCEQIAMILHMFNNEQLTTHGLEWQKILERLSRNQQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX73</accession>
    <name>A0AA38MX73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-lactaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1002795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX73"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3725064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="352" mass="38281" checksum="CAF0C4B089A00879" modified="2024-01-24" version="1">MPGIVPPGSKVLVSGANGYIAAWVVRTLLEKGYAVRGTVRSEEKGTHLKKIFAGYGEKFETVVVEDITKEGAFDEAVKGVHAIEHTASPFHFKADDPQELIEPAVNGTRSILKSALNESSIRRIVVTSSSAAILSILPERKVFTELDWNEQSIEEVKQGKNASQVSKYRASKTLAEKAAWDFYEASNTNRSWDLVVLNPPFVFGPIIHDVSSPAALGTSAGDWYNSVVRPDMGGKTIEAITTIGGGWVDVRDIALAHVLALQKQEAGGERLLISKGEFVYQDFIDTANALSPSPIPSHTDLPKGKPGAGKDFVAKIVYDATKASKILGPELVYHTMEETTRDTLADFEKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXA5</accession>
    <name>A0AA38MXA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1123200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXA5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3725603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="685" mass="78413" checksum="86AA9E26DBD737D4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXK2</accession>
    <name>A0AA38MXK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1004667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXK2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="83"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3720784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="290" mass="31981" checksum="8A40C8608E983834" modified="2024-01-24" version="1">MSLRIGYVREHFSSPLLQFAEADEGHTITLVECPSGTGQLISRLTKDEIDVAIALTDPLISGIANGSQAYKLIGSYVTTPLNWAVITGRDSKYEKISDLKDTTIGISRLGSGSQTMAYVMGFQQGWSPEGMKFQVNNDIQGLINSINDGSTSAFMWEWFTTKPWLDSGEVRFIGSVPTPWPSWLVAAQPSANTEALKQFLTTLSSYVSSFKSTERQETNNVEFIQSKFGYGEEDIKAWMKTVDYPQDCLAIPKDVIMNTLSILEKAGVVKSPEGGFNVNDFVESKVVKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXM2</accession>
    <name>A0AA38MXM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1041559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXM2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3725602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="422" mass="47405" checksum="AA43BAC2537F58D9" modified="2024-01-24" version="1">MADTLAEASYFIYVTQVYFCDAVVIWDWLVSFPREWRFVWKTHWTPVKVAYLFCRYWVIAVVPYLLYAFVKDHSKETCEKIYRIPVALAMWNQVGSESVLLIRTYAFFNRNRYILWFLLAAIGGVVAYQLYVDTTQMLLLPFVKPPFESGPCFPMSKPHSAHLLGFFIAPLLFDTVVTFMTVIKAIAIRRRNGGPNSRLIQTFLREGVFYYILISIANLINGIFYLQPRQVISAINIPLSVMMAPVLACRLILDLRERGSETVSHSDGTGMAAFTTKSVTQNSPFTPPHMRHKSSAYGAYGSRHARAIDSNIVLSTLGSIVADPMDLSLEQDLAETESRIGYGMDFSTAIGGDDGEPIPMAEHSSELISRDDLSDRDSPSIKTPAPTYRTLEMGFRPARAPSLTERGVGGIRVEVEKATATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXQ9</accession>
    <name>A0AA38MXQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_567525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXQ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3726393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1244" mass="141952" checksum="CB3F962A33639D3D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY70</accession>
    <name>A0AA38MY70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1156561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY70"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="357"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3729002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="510" mass="55864" checksum="866A14F30828AB22" modified="2024-01-24" version="1">MSDIYSTLSLSPKKKRAASNFDADTFTPKKLRIAPPTPPATRAHKSPIESAITLTPHLTRLQSIQTSLQQALSHALASCAASPSSDTGVLRNVVNHISLSHYAGLTTNFTVEDLRRLCWLWEWDGSSKDKNSVEDDDNPFLDAPSPSKDWTRGSMGFVISSATHFSTAEGKRVPAYGIGIEVEIDLDKIWVRLHAWAKLHADESVVPFVPLADLPALTSPSKTSSLTRVFASMSPKSSSFSLTKETMPVTPSSPSRSMKSPAKRGFVISASVNSISPAKSTILFPSTPTSSRTERTPRILNLRTPTSYKAITEDLPSEPSTPRGRDSTSILQTPTTSRRQALYDQVPGSKLTKEQILKMGQEEMRRRCLLGRLGGVAESVWMLFSSPTGATLTPSLRKRRTLPLAEVATAIMKSSPVPISQAEANESLELLITLCPFFLKQLTIGGEEWLEMPSSLSSDPSSPSRRTPPSPGKVDSAKELMTRSPKHVKRETGGLRQVREIIRRELELHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYB7</accession>
    <name>A0AA38MYB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_478784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYB7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3730022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="392" mass="43389" checksum="8C6723E4547B7682" modified="2024-01-24" version="1">MHLLHHQVQDKPVEKIQPQTNNLSEAQDEHIAKGLESMVAQSETNHDVSHGIHMHGKTVLEVPWIHKMIPGIEKLAANYHIGNFVVVRESGEKIFESMPIYARIGMHLLFYGSARETVLNYKSVEHLLQEQSIKQGTIYNSPESAKSIPSFVQTYSLDITELLEPDLTKYGCFNEFFFRKLKPDARPVENLENPKGICSAADCRLTVYPTLSLACKFWIKGDEFSIPNLLQVPVDSPTAIEFDGASLAIFRLAPADYHRFHCPIDGVVGEITNVPGQYYTVNPQAVNEPKFDVFTANVRSVLYLTHSATGKRVAFVAIGALLVGSIVWTKGAEKGTEVRKGEELGYFAYGGSTVVALFPKGVVEFDQDLVKNSEEPVETLVKVGSSLGTSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYR9</accession>
    <name>A0AA38MYR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1121097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYR9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="452"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3730876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="618" mass="67269" checksum="D3F2498B474BD9F9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYZ1</accession>
    <name>A0AA38MYZ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin Tsp2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_429100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYZ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43074" checksum="C9164E78F011E4E7" modified="2024-01-24" version="1">MSSQSASAEGSSTDLISLTVNYVPSKFSGALLEPSRPRRRRPKNAMSGVGAMGIPRGGGIDAFRTGEARIPGENDEDYDGVNVSKSWRIGNKFFRRTKQPTKLRWNTFKIILFVSNAVFSVYTLITLILCLLTWFDVFQNADVIRVGNRTELIFSTLAATFGLLTAVIGWAGILLNNRGFLAVYTFFLWITFAFLVVPGYLTYKKRTFNLEGKLNAQWSRALGAEGRLRIQNRLQCCGWFSPFVEATISQTCYARSILPGCKLAYLNLQRHILKKWYTISFGLVPLQLGAIIAGLLCSNHVTYRFGKGMMPKRYQLNSNAMKVIVDNYTNEIAEQYGRDVASDVIVKSGMQSYGSSLVHDHSDSNLLSSPSPSRVGRREMSTMADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N000</accession>
    <name>A0AA38N000_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetylglutamate kinase</fullName>
            <ecNumber evidence="6">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DFJ43DRAFT_1120337</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ET3784</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N000"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000046">
        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 19" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 19 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 19" id="KW-0521">NADP</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="21">
        <location>
            <begin position="333"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3731312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="886" mass="96720" checksum="58BAA26125D5DE36" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0R6</accession>
    <name>A0AA38N0R6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_318805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0R6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="509" mass="55019" checksum="982DB11B33AA0787" modified="2024-01-24" version="1">MVNLALSFPKCRPINYLRTRAGWYDSIIIAPVTIRPNTPPRSMTAARSPPHATGASHLLLSNPDTLARVAHPPAPSDLFAATSSIQAKTSKSSKPSSSRKAPSVIVHVPISPMYQNKTPHEDNPVPPKPKPKEFPDELVSSINESGKSMTMGAVIGSLPSTFRRIKVLSSAPPDKRKRGKTQTRPGKSVSLGKRRLNQIVSDTDSDSDSGDDSLHVATHRSKQMLASLNFRRSDVEQQREGRSDAASNAGPSTGATQRGRQRDRSVEIASFADTCGEGLLGAFSRSSSPKNPKHPSSKTGKASLPTARKRKERSSDNARDSAEFSRIPAKVSRPAGTSRSESLESGVHVHNQDPLLHNQEVLKVMSLLVDTIKEHHRLAEPGDAPLSVQQACQPPQDSTSHHPMPPSQPTIVAFFSPFGSPYVVNPPFPVGSPYFNNMPLNQPIVNPPFPVGSLYSNNMPLKQQIVNPHFPVGSMYSNNMPLDQPIVNPPSAVGSPHSNNIPLNQPIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1C2</accession>
    <name>A0AA38N1C2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1066998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1C2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="303" mass="33862" checksum="98041AD50A9283E1" modified="2024-01-24" version="1" fragment="single">MSAPFTNPQYGYSRFESLDHTPIHTGPSNYGYQHSSIYNHKGSEVDYHLPFDDMQLAALLQDAAPTIPEQYQNFADRSAFESQHFYHSDVVDDGACAPALLSWPVEYFVAPSGSDFISESFGSPSPSDSSTPDLMYSVSSLMDDTLNVFDMHFGAAIGSNHCHTPRYSNRDSGSLSPMSDSSTRSSRRSPIRTPSPPTDSSSRLDHRRRFPCLLPGCSRRFTSQYTLKVHMEAHKPKPKVSFPCALGCTERFSRQHDRLRHEVAKHGKVCEFSCEDCGRFFSSGKTLGNHRCPVAQGSTRWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1D3</accession>
    <name>A0AA38N1D3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_170097</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1D3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3733905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="476" mass="53390" checksum="F390C23188D148E0" modified="2024-01-24" version="1">MTSNPTFFPEEMSSDPTAPLSIHDLAKTLADTSLADSTANPTTTTGPALSVPTNSSNAPVVQSAPADASSHDQVVTPWDVQGSVSNDGKQQAIDYDKLIVQFGTRRIDEALLQRFEKLTGRKPHVLLRRGMFFSHREFDKILDRYEQGKPFFLYTGRGPSSDSMHLGHMIPFVFTKWLQDVFDVPLVIQLTDDEKFLFKHELKVEQTKAFARMNARDIIAVGVNPEKTFIFSDYDYVSGPFYENVSKISRQITYSQAKATFGFNDSDNIGKIHFASIQAAPSFSNSFPQIFGTVSNVPCLIPCAIDQDPYFRLTRDVAQKLKYPKPSLIHSKFFPALQGPQTKMSASDPNSSIYMTDKPAQIKNKINKHGFSGGQETEEEHRRLGGDTEVDVAYQYLTFFLEDDDELAKTGEDYRAGRLLTGQLKAKCIQLLQQFVSEFQERRAKITDEQINMFMDKTRKIVPTTSKTLAQPGPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1P4</accession>
    <name>A0AA38N1P4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_238380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1P4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041237584" description="Secreted peptide" evidence="2">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8449" checksum="3976EB650AB618DD" modified="2024-01-24" version="1">MVLVSVCCLLTSFVCSAVALVHDPLMLSLFFLSFLLCPLISSSYAWRLRVAPLLDVSVFISRSYALSFSVKGTKDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1X3</accession>
    <name>A0AA38N1X3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA binding protein Ncp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_158122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1X3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39571" checksum="2EE1B58E9A3B46EA" modified="2024-01-24" version="1">MPTTGRPTLDSKASSVSGNSVYYEAPLAHFHMTQDAQDPNLPISDVQESDLRREPTVAGGGTKIAPNAVQLSEVVDDDGDPEYADEPQRNDITAHPNGSEGWLPATDLPPPSDRALSPSSQPARSGSVLKKRRPGSIASKASSVHGGPTFDGVERNRSTRSVGSTRSRRSMFTNAEGKPVNGSTFINGAGATGPSATATADDSLHQRMQSADGALTGKQKKKIGQVEAKQGQRLSKVIKSESKVEKKSLEIAIQELGELQKIQKIAVKRESKAHTAHTKAVTAFHKAEEAYLAARTKYEIAQAAMQSEADNLEIARNNARGATENMQEKATEVDGLRKVFGVDEREREVMMNDLKGKPKDGKGSSFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2N2</accession>
    <name>A0AA38N2N2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome 60S biogenesis N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_174349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="708"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1698"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3733967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2102" mass="234789" checksum="D83CEBE3CAC3B4F3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2N6</accession>
    <name>A0AA38N2N6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_43337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2N6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="416" mass="45034" checksum="7C78ABDA62597215" modified="2024-01-24" version="1">MHLIAGFLFLLYVFAQVVIGAPIRITRNLDNDFDSPVGGGLTITDDIVDFSLLDFHPDFSPVGSSAGSWQSSNKELEHPSTTFPSEFFPSDREFVSNNVDQISDMKEEALPPSGETDLVIRPHTDLVVHSRSIKSLEKASKGMDTAGEVLGKVAKAADAIPEVGEIVGPAVQVVSWCVKLIGKLLNGVAEAERAAAHARGEFTQKVTDETLKEHPGWLVVTVHPKHTIYFQGQENIDWAHKTTSITTKVGVFQFEVYSARAGIFINDGDGGTENWAYSALADKLQAHGSQGHRLVYEGGAPPSGKPKSGSCGFHVYQYQKNEKSSNPTNHYTLVVVIKDAAGIIVGFEGNGDASTAVLVHSQLPQALQITAGPEDKSPLAFTYGKDTWKSDDKDRCKVGSYSSGSRQMDCSFQCTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N370</accession>
    <name>A0AA38N370_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_993998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N370"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="477" mass="52938" checksum="3327362A89AC9E9B" modified="2024-01-24" version="1">MPPTTRTRRESLRIEPDAVFAALDDDSTTPISAVTTDSPITPLATSPDSAAGSNEADNDGDTIAGSSSRKSREKRKRSRVTPEQLIHLERYFTVDRSPTAARRREISDLLGMQERQTQIWFQNRRAKAKVLDGKVKDRNVAISPDISSAKYDVDLHNIIHEDQAVTFIPCTDLSIGTWRRIATTVSKHDLVAYVCEAKQSLAWFIISGGGGFKMEVPFDRIIGTEFNHTSPGIAHAIFTLSEPPHFYLEHPMGPRPDGRMKLSWRQCSDWTEGAQATHILRHSLLGSAPQLSHLIQRLKLHRSDRNISLLSHSYKEDTIPSPLEIPAPPMAGLLRSPSVPSPYSNGSPDTGINSDSEQISHNPGAYTSQLQDASGLSSIYDEPQYPRLFGRYSTPDISSYHQSTNSAAHVTPVSRLSTARPYTVTQETFPSMYSDDVSIAQSLQSNRRHTWANIPEYVTPSLSLLTTPFQPAADFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3F6</accession>
    <name>A0AA38N3F6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1150583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3F6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF74">
        <property type="entry name" value="AGR407CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3735841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="422" mass="45417" checksum="804FABC8162C26B6" modified="2024-01-24" version="1">MSMASGVEKLNPKWLPARTFVGAQSFPLTLDTGSSDLWVISNECKSADCSNVARYSQSFSTNLSITQMPFHTDYISGSVSGLVAAETVSLGPYQLISQVFGLANCTEGISFSEEGNSGILGLAFPSEMSIPGMTVLQSIFTALPDPYFTITLGSKLNVNSSSSFTLGQIDDLYANDLSDFFTIPVSKAGANDYTYWKISLLYITINSTRISLSPSSVQGVQHSQIAVLDTGTTLALGPTRDVETFWASLGSAARNDPITGMWQVRCEKAIMVGFALGQEDSYREFVLDPADVSWENGASNNGWCLGGIQANDEVDSGDWLLGDNVYSLYHAANSSNGPWIGLLSITNNASALAAFRQSRGPDLDSSTPPAVQIQSAAVSPEVRYKLLYGTSTLCGFIGGVVLTSLFRARRGLWYAFRKQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3Z1</accession>
    <name>A0AA38N3Z1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1151344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3Z1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="289" mass="32418" checksum="449B153A2E7F2853" modified="2024-01-24" version="1">MLMQDLEPLDPSYVQQILSRPPFVYVSGVINVRDLGGHPSSTHPGKLTKPGFVYRSAEVAGITDEGKEQVRRLGIRKIFDLRSDTEISKYNAPLPVIEGVDLLHIPVFQTEDYSPEMMAKRYQLYASGKTEAFMELYSQILDHGGPAFGSILRFIRDHANEACMFHCTAGKDRTGVMAAILLKLAGVDNAVIANDYSLTRIGREPARAKIMERLSKEPLFASNNEAALIMFTCREETMLAFLELLDTKYGGVVEYIKNYVHLSESDIDIIRSNMFVSSDIVAEEDDTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N403</accession>
    <name>A0AA38N403_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_989114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N403"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="321" mass="35749" checksum="AD49C9B6195EF2F5" modified="2024-01-24" version="1">MPFVELDGAVDGPVKFNYNISTPTESSAASIDPTRPTILFLHGVYLAQETKPAAQFNDVNLRRFNLIGLDLRSYGQTVSRVPDDYSPQIAAQDVSLFMNALQLPPCHIFGLSMGSIVALQLAIDYPDKVLSLFLISPLGLAEPPEVIEGRRIMCEAWVEGCTAEEPDEELMFWGVSGGLELVCKDRHSNLMEALVSNVMQQVAVNWNKDHIREYRMTTLDFIINRKPREKEELSQIKVPVKLLHCLGDVAYSLEYTTEFLNLLKEAGVDASLNTIPEASHFGCCEDAHQVNPILHDFIMNVTKTEVPCAPESVSSPWNVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N492</accession>
    <name>A0AA38N492_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1057018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1542"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="865"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1664" mass="181510" checksum="7BAE0252CA59C681" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4E5</accession>
    <name>A0AA38N4E5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1056964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4E5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="16"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="262" mass="29194" checksum="67FA494133B4B96A" modified="2024-01-24" version="1">MPGRYHAQRKHIIQALDALLYQLFCFSFYLSPSMFNLFLRLSAQLVCATTRELSPTMSLGSFFFFPLFSNSFSLWNHATMGSTEGRAVVLDFVGLAYAPSKFQLLFVDFSIVFLELLLTIISFEIHTPESGTADSYDYLLPTPASPIPPLIPSRSLETSFANQKAFESPNSEPQYIVDIRFSSIRARLRNTPAISRTSNSQDTLIPFPNTTSWPIPMSLLMRAAGRRRQTTAERAVAPSRDTGQEDGGNRTVPGGMATDNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4P9</accession>
    <name>A0AA38N4P9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_990306</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4P9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="13">
        <location>
            <begin position="40"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3736067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="577" mass="62737" checksum="28CFCFDAAA963A9D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4Q5</accession>
    <name>A0AA38N4Q5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1047688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4Q5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="369" mass="41714" checksum="3B8F758F320BC67D" modified="2024-01-24" version="1">MHPWYIYGVCVWGCNLANSTLSTNMSLTNALKIEYRQLGRSGLRVSVPILGAMSIGDPNWNGWPLGEEQALPLLKHAWDRGVNTWDTANVYSNGESERIIGKAIKKYNIPRERLIILTKCYFLTHEESSANTFAMGYLKNTRDYVNQSGLSRQAIFNQVDASLKRLGTDYIDLLQIHRFDANTSVEETMEALHDLVRMGKVRYLGASSMWTWQFQMMNNVAEKNGWTKFISMQNRMSLLYREEEREMLAYCNFAGIGVIPWGPLHAGYLARPLGTATPRNEALKGTGFDRVLTSTDKAIVGRVAEVAEHKKWSMAQVALAWILTKVSSPIVGMNKPERVDEAIIGDKRLSSNEVAYLEELYRPLNVVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5V9</accession>
    <name>A0AA38N5V9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1148631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5V9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="1">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="255" mass="28555" checksum="6A41261C6C21B334" modified="2024-01-24" version="1">MTAQGQSIKDVLREAILLATGLAIFQNAFAPSDRQLVDSRNSILSTATSLKYPQIAHRFEQDRGFAKHLTNYVTGRIGNMRGQVKEVVQKVVPSLYGIHQVPIEDGQCKRFVSDLLLRLNYIFPRAMVTDSTTAHTNEPYLHPAIIAVLHKFFFHGRKLLGRRFQDTFSSMVDSNNAKEIPQAMLALVSVAIFAALKEWEQGLNESTSCEFVSANFSEQYDLHIMFLGTRILKTDGSGKGKYHALMARLYGEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1U8</accession>
    <name>A0AA38J1U8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytosine-purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1165865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000108">
        <property type="protein sequence ID" value="KAJ3712528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1U8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3712528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="513" mass="55418" checksum="4AC519393F3E4127" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3Z1</accession>
    <name>A0AA38J3Z1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1042921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3Z1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="359" mass="40817" checksum="99AECFC83A143B70" modified="2024-01-24" version="1">MRHSMQFQLNLVQYNRIINPIARSLWAMEGVQTNAADVFLLWLGIGAELRALFDLDEDITGIERGLAQKVIQIFNRCFKAFIKDNPDDPYFTTLYLDPHLYLKVGNTTSIFTLVQATGLVKALVEEFTPQLLAYSRREYPFTDPIGDKSMLQWWRELLLNPKGRVVAFCAVKLYSILVNSMPDERWGSRKTRMNAPLRNKQKPSTIANMIQIGEWYGTHMTTTLKFLQKPEKPHKKPCVGFESGKIINSKNRSKIPDTSSEVSASHLDLHLDSEMALYSALDSEDEDESDSMPVEMPFSDIDFDVDEDIELGSDLLRKVIPKECDAPLPVFEAFLEHGIKAAGVVGDVSIEEEVDWEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5A6</accession>
    <name>A0AA38J5A6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1005665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5A6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="99"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3719040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="194" mass="21090" checksum="5788B5D319548DCF" modified="2024-01-24" version="1">MPHADSSLVPDEIQTKAQFWSHVYTQLEPLLDGQRNWVSNLANASSLIYNALLAFRTHFGPDPGRSVNWCGFYIDSACFPKSADSNVEGSRLLLGPFCGKPACQFINVTPGKARGVCADAFMHAKTKLVPDVDSYPGHIACDGETKSEIVCPLLNGNQVLGVLDLDCLAIGGFDEDDQKGLERITELVVTACDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5Q8</accession>
    <name>A0AA38J5Q8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1044721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000160">
        <property type="protein sequence ID" value="KAJ3709737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5Q8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="56"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3709737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="286" mass="31798" checksum="1D2F5D124EC17240" modified="2024-01-24" version="1">MIFVGVVISAVKCFLDYRNVPMITGIYAWFLMKASIARWEVDMSGFGNGEFEMTTDSENNSFVANGHLYILPTLTSDSIPMADILDGHVYNISGCTTTLPGPILHRFFLNTATSLNETAIGSNTSTLKLTIKRVLRARLSTRKTASMKFGRVDVVAKIPTGDWTTHTGRGPLSGEIDIMEARGNGPSYPKQGTDYVRGSLNWLELNINEAFWDRGDFPAVVQNGSEVVALQDPWINGTKAAHLINTLNLAAMRDFLEAQDQWYPTWPTNPDERAFVIDSVKMYEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5W3</accession>
    <name>A0AA38J5W3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_685756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5W3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3721435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="261" mass="28673" checksum="6079D81061CB1EFE" modified="2024-01-24" version="1">MDEAYMDKKIVDLSDDELVKLGFLGPNVAPGIKSLVEKIKANPVYLGNVTCFMVDVTKRKYAAQAQPPASPISTTVNEAEMLYSELSNDPTALTVIVPELISQYERNFYYHGVSGNPPKLLWRSDLETNPFPIPPPETSFYKIPTKTAFGVFNTRLNEVWDDSVAPQILASMKAHGLKYSALETARFLTVEEGGHESFGPIVVWIAVRPNTTNAEAVRDATPDILRILANVQITDAVVEWYEGSVVSLSGPALKVNGESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6G5</accession>
    <name>A0AA38J6G5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1123941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6G5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3723460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="383" mass="41433" checksum="5CE062F62D3EFC03" modified="2024-01-24" version="1">MNQDDPYLWQKTPLILSAPISRLLGVNAFLKFENVHPSYSYKFRGMSLFVHEAMKKQGQDVHFVTASGGNAGLAVACAANVAGARCTVYLPEGAAESTVELLKAQNAEVVIAGKFYQEAFNAAQQRTTTDKNAIVVPAYDDPVLWEGHSSMIAETFEQLKQWSVTEPDAICCSVGGGGMLAGIIIGCQKVKWDHVPLVALETMGSNCFHHSILLNSSGSSIFATELPPYVTKVHDESSQLDLAHFNSFHSKASGSLGASQPATGTVRMALERKGGIRCVTIPDELCMQSAIAFANDHKTLVELACSTTLSAAYKPQLLDAVIPPRSDGHKRNVVFIVCGGFKVNLGELAQYEEELKAEIERNVTGSWEVILNDGHIVNVDYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6T4</accession>
    <name>A0AA38J6T4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1135053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000111">
        <property type="protein sequence ID" value="KAJ3712115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6T4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="96548" checksum="D751F240BF66D1C3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7D7</accession>
    <name>A0AA38J7D7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxy-acyl-CoA-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1083030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7D7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="58"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3729969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="341" mass="37182" checksum="304FBCDDB8F03CD1" modified="2024-01-24" version="1">MVPTHICSCSRCCKHHGLFLYHHYDVLLFCYVSEYSHRVASYFSDITASFDTMKISNRTFVVSGGSSGLGLATVRDLLQGNAYVAVLDLSSVPSDLIADEGSSNNIQKRRLLYIKMDVTQEDQVESAVDRVVEWSKSTGAHLGGVINGAGIAAAELTINRRGQPHSTRTWDRVLAVNLTGTFHLTRLVAKHLVTVPREYQLLQTEGAAGESKGAEGMQESDGERGVIVMIASTVAYEGQAGQIAYAASKGAIRSMTLPMARDMSRYGVRVVSIAPGPFKTPMTGQFSQSMTSRLEKEAVLFPKRYGTPEEFAATVRWILECAYVNGETLKLTGGTRVPTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7E5</accession>
    <name>A0AA38J7E5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000096">
        <property type="protein sequence ID" value="KAJ3713774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7E5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="203" mass="22196" checksum="A54A90B9C1EE6ACB" modified="2024-01-24" version="1">MSSLPATEPIPTFITARIAARPRVIPLYATPILNRPRRTLSIHHVLPAKPYARAERNGLESPASTAVSSGSSTESGATANVGDLLSEPRLILIPPPNANVTVKSSGWHAASAKEYRKFARKAVDMYLDHTVNLSSQDSAALERAREHIEQAVPFFKAHLKHWGADTLLREQLKSKKDTIAKAEAKGKGKGKEREKSDEEETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8A8</accession>
    <name>A0AA38J8A8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase family M48-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1085681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8A8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3728069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="412" mass="45234" checksum="D9EBE637E40A0863" modified="2024-01-24" version="1">MLRHVCGRESYQSLSRRLSHPPSLSYHFHSSTIRRSSPPPPRYVRFSPPSNPNSNSGGGRRNGKSFLEDRTWPVKVGAGLAGMGVIYYVSCLEQVPETGRWRFIAVSPETEAEVGKMVLQETMAQYKGRILPQDHPVTMHVKRIVHNVLSASHLGIVKGYSEPQKQLLGNDFGADDVWSASSSTNSPPLAIASANKEWAVVVVDDRKFANAAATPGTIIVFTGILPVCKDEQGLAAVLSHEISHVVARHTAERLSSQTIATALGLFLSIFGVSFGFSATLNTLLLELPNSRLQESEADLIGLRLMSKACYDPKASPAMFARLAQLESQASRGGFGAPEFLRTHPTSESRVRDLQAHLGEGYDIIAANPTCAELQDQAQAFRETTRLRNAFNLGHNGHDHHRQHGEDEDEVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA18</accession>
    <name>A0AA38JA18_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1103422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000089">
        <property type="protein sequence ID" value="KAJ3714653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA18"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3714653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="230" mass="25959" checksum="F2D0094DA5FA1884" modified="2024-01-24" version="1">MIVVHHLSNSRSQRILWLLEELGLPYEVKRYERMPDYTAPPSLLDVHPLGKSPVIEDKDEGVVLAESSAIITYIILKYGEKQSLSAEGALDDLYYTHYAESTLLPLVVIWQRLSRFTNRAPWFLRPIFRYVLGAYREMYVDPDLSKNSEMIEKHLSKNIWFARGSNEPTAADYAMIIGLEGLYLGKAVQSNTHPAIAGYIEKVHARPAYQSGLRKGGAFAYPKQLDAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA23</accession>
    <name>A0AA38JA23_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1094182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA23"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="102"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3721400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="288" mass="32639" checksum="C07362784934A02E" modified="2024-01-24" version="1">MATTDIKGEYQPPPGYLGNLSSEQQSALDQLKKELKGQKETEFALEGEDTFVESRMGDAGLLRFLRARKFNVAASKAMWLANEKWRKEFGVDEIVKSFDYHEKADVDKYYPQFYHKVDKDGRPLYIERLGTLDIDALYSVTTPERQLKRLVYEYEKSMTERLPACSALVGHPVSTYCTILDLKDVSIRSFYRVKDYVMSAASIGQDHYPETMGKFYIINAPFLFTGVWSVVKPWLDEVTVAKIQVLGAKNKDVLLAQIPEENLPKSLGGSCQCSEGCSLSDAGPWNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAH8</accession>
    <name>A0AA38JAH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">DFJ43DRAFT_1007784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAH8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="33"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="403"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3714570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="584" mass="63155" checksum="B6A98D985C25FACE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAP1</accession>
    <name>A0AA38JAP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1160210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000080">
        <property type="protein sequence ID" value="KAJ3716240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAP1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="155" mass="16720" checksum="2B6BC04771BE6DC7" modified="2024-01-24" version="1">MSVPPQAAALRSPLAIVFLLHIALETPIAIQGLFSPMSLPFIQLNNTSILLLKLYASLSLGISITSLLAYPLPDFLPAKRALAIGLCVYHSVVSTVLFQAPRFIPHTFGALAEANKVTPEIVWGTFHGLVGLGMIFWWQATVGMTAQLAAVQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAZ3</accession>
    <name>A0AA38JAZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1101518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000081">
        <property type="protein sequence ID" value="KAJ3715962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAZ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3715962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="423" mass="48869" checksum="5E0570AE4D44F155" modified="2024-01-24" version="1">MKKYVFAHFMVGNTFPYTQQDWLEDITLAYEHNIDGFALNIGNEAWQLDRISDCFAAASKTKVPFWFFFSFDMSSLPSTTAEDIQFMCRYVKRFGKNERMFRYGHVPGLFVSTFAGEQSLFGQPTLDDAWNFVKDRLASAVQCSIHYVPSLFIDPALYSGMTSLDGAFNWNGSWPVHLNSNSTRQEIECPTLDSDDEHIRNLNGRTFMSAVSPWFFTHYGPESWNKNWIYRGDDWLFVRRWEQLVTMRDRVNIVQIISWNDYGESHYIGPIKGAQPNSQSWVDGYPHIAFLKIAKYFIRTFKEGRYPPVYEDQIFAWARPHPKNAIASNDRVPKPEHWDLTDDKVWIVVFAKSAATVSMHGRSTFEVDVRAGFTKLCQALKPKDGIDITMERNGAVVAKCSPLKFTFEPRPSMYNFNVFTACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB01</accession>
    <name>A0AA38JB01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1069822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB01"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="59"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="469" mass="51484" checksum="7FEA804B5191161C" modified="2024-01-24" version="1">MMGSHSIWQVEKGERSLIINESSAPKMQMEKEQLSFDFGFLPIPKHLRYTPDGPLRFSIARNAAFGICTTFVVANLYYSQPLLIQLSLYFHVSYEEISRVPTLLQAGYAAGVVLVSPLGDLVPRRPLLLGVVLADIFFTLGLAVTHSAHVFEALSFVVGVTSVAPQILTPFAADLAPENRRASAISIIFAGLLFGILIARVLSGIVAQFSTWRIIYYIDVGLLTAVLITLYFVVPEHPSKNRGLTYLEILTSMVKLSTTEPVLIQASLITMGSNACYMNFWVTLTFILGGSPYHYSTLVIGLFGLIGMFGVSMGPILGRGIDRLVTWYAILIPTFFMAIFWAVQTAAAGVNISAIVLVCIGLDLCDAMQQVSLSTAVFSISESARARLNAVLILSNFIGQFTGTAAATKVYLEHGWRASAALGLACAAFQLLILFFRGPHCERYTWFGYQGGMDWKKMDKKDDKDQPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB66</accession>
    <name>A0AA38JB66_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1141336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB66"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="117" mass="13178" checksum="F1B617C49C8F1729" modified="2024-01-24" version="1">MVILSLSASQFLSVVFSILLSMKVMGRPLLTTAQLERRLVFSESPTSCGHPNWPTEIWTTYIGSENGFRAETNYDTNPELNPNWPWVVEKVPQKLESDSPQAVNVNLQSRHTSSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBB1</accession>
    <name>A0AA38JBB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBB1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041369897" evidence="1">
        <location>
            <begin position="30"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="198" mass="22101" checksum="D0E14E616BDC601E" modified="2024-01-24" version="1">MVYLNLCGATFKALVLMVLGLASVVPLVAVPVSAPASPGSQQSRTVYATVWFKDVEEGQRITSDDIQHLQWATRKLMEKFTAKEYNTANIPFLSWKDGPTKFAPDGVDFTFSIEEPQAPEGIRYHSGRVQLQLSRNGWKYRGSIWNKVKPAKEDKPAVVKNTWTTLSPTVNIVRLHILFVLTGAHILSSRSRASKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBL4</accession>
    <name>A0AA38JBL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-iditol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1153607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBL4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08286">
        <property type="entry name" value="FDH_like_ADH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="2"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3733241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="347" mass="36695" checksum="AFA0A42DFB4DA98A" modified="2024-01-24" version="1">MTTMKALVYAATGKPTLEDRPKPTILKPTDAIVKMIKTTICGTDLHIFKGDVATCDTGRIIGHEGVAVVEQVGDKVSHFKPGDKVIVSCITSCTTCTNCRTGMPSHCTDGGWTLGNTIDGTQAEYTRVPHADGSLHRVAKNASDDAQLMLSDIVPTGYECGVLQGKVKLGSTVAIVGSGPVGLSALITSQLFSPLQVIMIDLNEKRLSTARSLGATHTVVSGPNAVEQVMKLTAGRGVDTVIEAVGIPATFELCQKLVAVGGTIANLGVHGAKVDLHMEKLWDRNITITTRLVSTTSTSMLIKLVESGKIQPEKVSTHNFAFGDIEKAYSIFGAAESHNCLKVVINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBY7</accession>
    <name>A0AA38JBY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1065528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBY7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="191" mass="20815" checksum="1FAD68DEF1A17617" modified="2024-01-24" version="1">MHCNRSYGVVLDIVIILGLVSAALAAALSPILEHPSPKSSLDASSQAIRPTVDVTFHGNFPGVDVTRSARIDVQAILYEAARKIHGTPDFTINEATWDAKQQSENTEKITFEVSVSGLRPEDCGIYTGFYFYSGVLPVPKERKSKSKPAKPNDRIERILTAKLLNPQGASLLDLKVPEARILQMGLQSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC08</accession>
    <name>A0AA38JC08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1125734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC08"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3719066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1116" mass="123680" checksum="C2EC6F485725A48E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCX2</accession>
    <name>A0AA38JCX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1201906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCX2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="248" mass="28736" checksum="6753B9AFEF02C974" modified="2024-01-24" version="1">MPFGSRQFGSPSHLKSSKHSKGLEKADISRLMDPSYCLPHHHLSQPVATHVDSKGQMHDPDFRCFPVFSTGRSRRRRSPFASSRSPWDEGVDEADEEDEEMPTQRHNRRQSPRLSRQHDSASTSVDYSYHHVNSYDSPSSSSSSPSSDSSSISSFTDKIHRYNFVAKIRSFGFVDWYYHYDPDYTYEEPIAIQMNEEYISESDLAENIRAKQATPLNYCHTMKQRWMKSRFGDAFKRKHSNLSTFTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD89</accession>
    <name>A0AA38JD89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1084672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD89"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="62"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="156"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3729081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="453" mass="49937" checksum="099DA2D059FEA32A" modified="2024-01-24" version="1">MSTHPVVELTSEASWAMVEDKFSPYAKETLAKLIEFMENEILPAIKVAHAQLPIDPNMRWKTVIPIIEELKVKAKKLGLWNLFLSKAHYPEFGVSLTNLEYAVMAEILGRGGHFAPQVVNCSAPDTGNMEVLARYANREQQQKWLVPLLNGEIRSAFAMTEKHVASSDATNIRTSLRREGDEIVINGHKWWISGAGDPRCKVHLVLGKSDPGNKSAYHQQSIVLVPADTAGVKIIRPMKVFGYDDAPEGHCEIIYDNVRVPVGNLVLGWGKGFEIIQGRLGPGRIHHCMRSIGAAQYALDTMLRRVTDPAKKTFGKYLYEHGTVVADIAKSRAEIEGARLLVLSAALQIDKVKAKGALKEIGIAKFVVPSMALEVIDRAMQSFGAEGLSQDQELASAWAGLRTLRIADGPDAVHIQQVGLKELKRAPALVQKDMEIKRKQALLMEKAGVKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDH0</accession>
    <name>A0AA38JDH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1228205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000098">
        <property type="protein sequence ID" value="KAJ3713489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDH0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36504" checksum="D74EA7FCF14BBB29" modified="2024-01-24" version="1">MVMDRGNKNDIDITIMEKCKKAVLDTMQVLNIDPLAIVPFDQSPTFNPFVARCIEAARQRNYLTDAFQEKHVIIGAAAAHHAYLFHEGTESHNVPVLSSLLMAFIYFIDDHGFQQRSIAEFGSRLVSGRSQLEKGLDDIVAATTELADMYTPITGDLLRLTIQAYVMSNQLEEELESGGVQSKWQVNKDAPFFPTIMKTFTSCGTLAYLLSFPCNINSTSYIQALVDGIWVHDITSDIMSYYKEAINGEFTRIEQVAQMQGLSGSAVLEDLVKTMAQSHERVIRVLSASDPSGSLLLYYTRAIRGFVVFQALYPRYKIADFGIFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDT1</accession>
    <name>A0AA38JDT1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exocyst complex component sec6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1007751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDT1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3714571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="749" mass="85520" checksum="5BEB8824049D4C2C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE36</accession>
    <name>A0AA38JE36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1088724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE36"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="251" mass="26385" checksum="F85B9DAC648B74A1" modified="2024-01-24" version="1">MESEEAEGSSEAVKDESAGVKVEGESMADNHTSLSSTTPSDSLKSQNVIGNQTSPERSQSKSRPGLHTRARTRPHAPTLSSMPALSDLSLHSPSNIVGTPFTVNSVPYEYPFPPNAQSSDATFPPLTPPSLLSASLSLSGPTVALSTSSPFGPDARSYSPTHPKMRPVDPPIPPGLVKKRQRWSLTLTRRESSFGSQTSEGSTSSGTGTRSHRAFSLDDAPPTVPPQATLPERTSSGKTSPVPGTADDNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF02</accession>
    <name>A0AA38JF02_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1134403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF02"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="3">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3717646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="297" mass="30126" checksum="4D9C1F34BB1C8C3E" modified="2024-01-24" version="1">MSASVSPAKSTTGAAPASPAKSTGKPASTAAKSAKPASKASGAKKAATTKKAAAARKATTTKPKAVVTKSKASSSSSSALKPSWKEIIKECIILHKDEARQGVSRSTIKKYAEEKYKLEMNASHLSQLNRAITHGADTGVFMLPKGPSGKVKLPPKNSKATDDTKENAKPPSKTPGAKAPVKKASVKKAPAPAAKKTAPKATTSKATTSKPTTSKPTTAKKTTNKPTTKKVLAGKPKAAIATRKTSVVTKRAAAKKAVTGTTAASKAKAAAKKPAAKKGAATAKKPTATTKSRAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF18</accession>
    <name>A0AA38JF18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1151893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF18"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="121" mass="13348" checksum="3CD717EC6D45F62C" modified="2024-01-24" version="1">MPMRLRLAVHGFRHDRVFHLVAINQRTRRNGKPTELLGIYDPRVKPGGKDHKTMEWSVGRIRYWLDVGAIPSKSVVRLLTMGNILKPGSPYHQTSPSVMSPSASTGSSSTEASSSPAPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFP7</accession>
    <name>A0AA38JFP7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_992288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFP7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8040" evidence="2">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="105" mass="12277" checksum="976F61903AACB69C" modified="2024-01-24" version="1" fragment="single">MDQSQHTLEPLHKLVAAYAFLMNVITTVALIYTSPYYWKQEYHNSAFTGHAWIQELIHGHPDRIRSELGVRLPVFVALVEQLRVLGMENTRYITIEEQVAIFLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGK3</accession>
    <name>A0AA38JGK3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1132954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGK3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="153"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3728977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43794" checksum="ABE94CCDD82BB8D9" modified="2024-01-24" version="1">MEPIKCCAIGAGLATLTFHVPFILALPSLFTLHSVLERNPPSPSGTVCDKFKLSSSEVKLYQSFDEVLSDPEIELVLIGTPNDTHHVLAKAALKAGKHVLVDKPVTPSVQEAKELGQLAKEKRKVLYAFQNRRWDQDYLALKKLLDLPDSDSRSLGTIVEFESHFDRYRLGLKGSWKDDPRPAAGLMFDLGSHLIDQTLCLFGRPTQITAFASNLRGIGHPNVDDNFTIHMHYPAGSALPYPFTAILRAHPLSVRSPQIRFILLGQKGSYIKYGIDVQEEQLKSLTSAPSRTVTTPTTTPTPEYLITSPSSGYGLEPESYWGTLEHATDPNGTTFVKSVWPSEESGCYTDLYRNLAATIRENAELKVKWEEATAVIEMIELARKSAREGKTIDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGQ9</accession>
    <name>A0AA38JGQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1058145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGQ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="523" mass="55975" checksum="E5FF3C4083422ACB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH07</accession>
    <name>A0AA38JH07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="5">4.1.1.48</ecNumber>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_990818</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="5"/>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="15">
        <location>
            <begin position="7"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3735776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="283" mass="31088" checksum="ED54A2147528E3E3" modified="2024-01-24" version="1">MSAPTILEKIYAQRQKDVEAAKATPGTTLEDIQTYLEMSLAPTQISLVPRLRTNPSTDTADPSLSLMAEIKRASPSKGEIAMDTNPAKQALIYALSGASVISVLTEPTWFKGSLLDMRLVRQAVDKLPNRPAILRKEFIFDEYQIAEARLHGADTVLLIVAMLTQEQLTRLYTYSLSLGMEPLVEVNNAAEMARALELNAKVVGVNNRNLHNFNVDMGTTSRLVDMVKEKDVLLCALSGISGPHDVKVYKEQGVNAVLVGEALMRAADTAVFIRELLNWPHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH12</accession>
    <name>A0AA38JH12_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1149856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH12"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041487362" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="351" mass="37575" checksum="C72E9052631DD01A" modified="2024-01-24" version="1">MFFQKTWQSLVLLVSLPLGNCLTYHGADYSSLVNLEDSGITYKDSGTSEKFDTILANHGVNLARIRIWTSTNDADYSLDYGLALAERAVAAGMSLLIDLHYSDTWADPGDQATPSSWPTDLDGLNTEIYDYTNSLVTAFANQGTPIDFLQIGNEINSGILFPTGEISVNGYSPLSQLLHSAANGAHDASDSVKIVVHLANGWDGSAMSSFYEQIFIQGEFATTDFDVMGFSFYPFYDSAATYSALQSSLDNLVATYGKDVMIVETDWPSSGSCSGVTLSEDFAISTSGQESWVSGITEILAGLSDGHGLGVVYWEPGWIGNDGLGSGCSNNLVVDDSGNTLASIDLFSADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH31</accession>
    <name>A0AA38JH31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_1154299</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="785"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1350"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3732574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1373" mass="149034" checksum="83029B243E6962A7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH80</accession>
    <name>A0AA38JH80_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1080576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH80"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041263701" description="Cupredoxin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="20961" checksum="F366288ACEE44EDB" modified="2024-01-24" version="1">MRFFAVVAALVSAVAADTFTVIVGGNSTITYNPTSINATNGDVIQFQFVSKNHTVTQSTFAAPCTAMAGGVDSGFQDVATNASTFPVWSFTLTNTSAPLWFFCAQTGHCANDGMVFAVNPTAAKSFEAFQTAALATGTGTNSTTTNSTASATSSGASTSSTADSTVATASAAVASQSASGAVATANGASTLASDTIVGLVTVFGVGVGLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHD0</accession>
    <name>A0AA38JHD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHD0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="220" mass="24672" checksum="993397AFD74B950B" modified="2024-01-24" version="1">MPIRVGIALYYVAGLYGAPSYFHWILVASSADTWAPQPILALELKKTFSTYIQSFTHCDVLRSTAFTGIVHLFTTTRYTPQTFYATIKDNFPATDPGWRFPGVYGPQGWTCATWILQILWRMREEGTWVSDRNFDHTYTRVLNLGSELIERTKNVEYQGGVRIGFHTMTMEAGVFPHVTYATATSLVKAPANYAGDPLIRLESGKSDGSQSPETSDAHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHI8</accession>
    <name>A0AA38JHI8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1099813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHI8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="106" mass="11054" checksum="846C9B8D37584B59" modified="2024-01-24" version="1">MSLLLRTTISRVSATSSVRAFHASPTASKTITEKVSEMADNVNKKLGKGLASAIDKGEQATASTQDSLGNAAQKTQESATAAKQKANQASAGATQAKEDFKKEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHV4</accession>
    <name>A0AA38JHV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1189621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHV4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46868" checksum="6AAC2748754E94B0" modified="2024-01-24" version="1">MTAPAPYAEHFLNLKRQIAESYPDFQTRATQAWAEIIDELEKLAVTVSANGSKYIPQVNFSELSSLSSEKVEEIRRVGTVVIKDVVDDAEARYWQDSLKDFIKANPNVRGFPEDDKQFFELYWTKPQVQARSHPNLLAASAWLNNLYRDPENNSLDGVDLSTPLTYADRFRIRHPGVQWDDSAFRTCFDDILSGQWRKHDPYALSGRLNARSSLYRRPNQATVFRTFQGWLAMSETEPHQGTLKVFPDVVLSNAYIILRPFFRPLVPTDSKDILDVKNWAYDTSYAEFPGIIPRDGGFTGPRPTSDTHPHLMLDKTMTSVPKVMPGDTVFWHCDVVHSVELEHTGKDDSAVMYIPAMPTTPMNKAYVERQKESFLQGVSPPDFPKSSQNFVGIGRSTDFLSPIGLQAMGLPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI98</accession>
    <name>A0AA38JI98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1097938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI98"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041326710" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3718615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="136" mass="13951" checksum="F3B272312BE9D42C" modified="2024-01-24" version="1">MFARISLFALVTALGAIMGANVLAQTSCQATYTVVFGDNCVAIAAKFNVSDAALLAANPAVDSNCDNLFVGQQLCIPTAPASCQAQYTVKSGDVCISIANMFNITAAQLEAANSDIDPLCDNLQPGEVLCIPAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JID8</accession>
    <name>A0AA38JID8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1136663</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JID8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="13">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="59"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3735789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="209" mass="22987" checksum="1CE1DC5584CF0911" modified="2024-01-24" version="1">MFSRLRRVPLQRCLHTQAPHTLAKARSFRLGFTLAASATVLSYTTWRWTRDQRIALDSVTASETTKTPALDGPSSETHHTSASPSEKSESVASSTEQQQSEAETSDNASQGAYNPETGEINWDCPCLGGMAYGPCGPEFREAFSCFIYSEEEPKGINCVEKFQAMQTCFRAHPEVYADEIMDDEEDGKTAEGATEEAPAGVINIFRIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIJ3</accession>
    <name>A0AA38JIJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1155729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="77"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1545" mass="164882" checksum="0215EF3C88DFFA43" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIU4</accession>
    <name>A0AA38JIU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_557765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3726474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="398" mass="45396" checksum="2DAFCD51A7480A0A" modified="2024-01-24" version="1">MQTPRMRNLLRLKFVSKPKSSSNNRSANSVDALGWLIDIVDTVQSASVVAPFPQIQGAASALSVLLKCIQKVYQNNEEFKELLERIKSILEVIQKVVDESDKAMCARMNDVLLEFEASLRDIVQTINSQRQRNDKWIKQFLHSHSVSESVLRLKTKLDDVRLNVLVNATFTHHSVMREQVSRIDKKLEVGIASQATVAVETQSALSQLQQQSQTLHTETQAQSFLISKNQTGLMAAFTTQGQHIRDSLHAQDKLAVQHHLQTVKDLNQHQSWLQNTLVDQNQLVIRQHDEVMNAVRRTMPTPLSSPKDMDGFEEYEENFQVFKQSEWKPKQILLSSDEEEGSWMSTDSQVLVIDQTSVVGSIKYRVRTFKAASHNKPEQQDAAFKVFKDHLQFYSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ73</accession>
    <name>A0AA38JJ73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EVE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_990136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ73"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="280" mass="31682" checksum="941AECE041944476" modified="2024-01-24" version="1">MSLTRTPMLWLLKAEPDSRIVKGKDVKFSVDDFESVKTSPWEGVRNYEARNLMKEMKSEEQESFKACFWDGRCAAIGIAAFAEVSTEAYPDHTAWDSSHPYYDPKSDKSSPKWFMVDLTFKSRAQHFVSLTLLKYISEHVDDLPEELEYIGSEGAKAIKGMDLINRGRLSVQRIQKPVRDVIKLLAERGGWDELMFGKGKGKSKGAGSGNVSKNRKNKGKESTREEDVESEDQREENEKDGYNQKSPPGKADGKGKGRKRKAEGNEHVDQRPATRARTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ90</accession>
    <name>A0AA38JJ90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1140039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3727991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ90"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3727991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="120" mass="13139" checksum="51738C6657AB7A77" modified="2024-01-24" version="1">MYKLILVQANLLPTVQELGAGFNKPSGQEGLLVEVLVVAIVVKAVQPERITIKVPEASDEVPSVGTVAVTQGCTRKGYTVLGSMMGLQRSFRQRSLHAIWVSLRSAKKKEVPERRTEPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ97</accession>
    <name>A0AA38JJ97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1156804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3728006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="646" mass="71698" checksum="D8BF69F164C3A668" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJE9</accession>
    <name>A0AA38JJE9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1048637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJE9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3736976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="431" mass="46555" checksum="8844E2D03B7F31CE" modified="2024-01-24" version="1">MSASTIARWNAISLTRSDEPTSLKRKHEEDSDDDVSIVSRSPSPTHEAMDVDQESISKYDEYIHRPAREVITVETPLKSTNKGFAMLAKLGWVEGQPLGISGQGRVDPIPFQMKADSTGLGKVRQDVEMIETTVSQRRELDSERQQKETEDQRRSRENIVARKSAVAEELSDILKAFYCTLCEKQFQNVAQYDEHTNSYAHHHKARFKDMQASARIKPQEEIDKRKEKERKREEKELRKIAAASGVRMAKTTLPPTGAPVLAPVANSSSSELKSSGWASVSGPDTSIPSSSGGGFMKAGWASVGSSPEVPSIGSVPAATPSSGGFQKAGWATVGSTASLGAQPPAAPSSGGWKSVNSSSSVVSSTSFRKDGWSTQNPSSSSANVPVPPGEPVVPPPAVEPISQPNPPPLPSKSHLSRVGWQQFQKKNSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJI3</accession>
    <name>A0AA38JJI3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_988618</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJI3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="465" mass="50588" checksum="F9F5408DBFA32C06" modified="2024-01-24" version="1">MSSFKRKSSSKTQSLPGTRPSPGSIATTITSTGIPSLDDILGGGLPLSCSFVVAAPDPHSSYGELVQKTFVSQGLACKQDVLVVGSDQDALDWVKGCMWFHSSASSNPSLEEDAEDQKPTDEEQKIKIAWRYEQMKQFQTTVGSTSYVISEDFCRTFDLTTRIPSFTIEKALNDGQLYTCNVLDTLDPTSRSECFSVTQAVLLNIEDVLSQRSSKIPNTPLRICIPGLGSYAWGDLRTQDILQFLYQLRAILRRNPFACASIGLESHISTDAWGGPGWIQKLGWMCDGLITLDAFTTNPSLSTLFPSHHGLVHIHTLPSPHTLLPSSDRFSTLRGLSASVSEGGNSSGENNLAFKCTRKRLIFETMHLDVEGGVAERRTVPASSDGVLDNYNSHVSSIPVPKTELASVEVELDPGSAAKAVPTPSPSHDDTGATVVEEAQAPKPRLKKAKKTVAFWSDRPDLYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJN1</accession>
    <name>A0AA38JJN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1049122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJN1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="200"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="575"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="869"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="921" mass="97812" checksum="72A353BD9432F896" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJR5</accession>
    <name>A0AA38JJR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1131768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJR5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="324" mass="36643" checksum="4B7E9862D4F150D1" modified="2024-01-24" version="1">MSLWVDQASSGDFPHMLFYGPSGAGKKTRITCTLKELFGPGVEKLKIDQRVFLSPSRRKLEVNIVQSNFHIEITPSEAGNYDRVVIQELLKEIAQTQQVDLNAKQRFKVVIINEADSLSRDAQAALRRTMEKFMSNMRIILCANSTSRLIAPIKSRCLLMRVAAPNAEDMQAVMQHVSKRVGFDLPPDVASKIIDDSGGNLRKAILCLEALKMQSPDLSGVLTIAKPDWETYCHKVADLIISEQSPARIMEVRQKFYELLSHCIPPATILKTVADRVVERVDDAIKADVMHWAAVYIYHLEAWVVKVMSLYKHFFYGMDLTEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKL6</accession>
    <name>A0AA38JKL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase</fullName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1178462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKL6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="11">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3733033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="368" mass="40715" checksum="A8CB667D6A92E342" modified="2024-01-24" version="1" fragment="single">TSAILCQSQSCLNDNPPSRMECPTCNKLGIRGSFFCGQDCFKAGWKTHKLIHELAKNPSSSTNVGKSSDSYNPFPNFSFAGTIRPLYPLSPRRTVPDHIPRPDYATTGTPFSELRETGPPRILNSEEIEKMRTACRLSREVLDIAASHVRPGITTDELDEIVHNATIERNAYPSTMNYRGYPKSVCTSINEVICHGIPDQRILQEGDIVNIALSFLSQGYHGDVNATYPVGKIDEDSQRLIRTTRESLDAAIKICKPGALIRDLGKTIEPIARANGCAVVRTYTGHGIHELFHCSPNIPHYAKNKAVGTMKTGMIFTIEPMLNLGTNWSEIHWPDNWTATTVDGKRSAQFEETLLITETGVEILTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL06</accession>
    <name>A0AA38JL06_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_174184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="818" mass="91943" checksum="1E0ABA1C242365CD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JND7</accession>
    <name>A0AA38JND7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1023459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JND7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="838" mass="95235" checksum="174D69310CE85C38" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNE6</accession>
    <name>A0AA38JNE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1152824</name>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="643" mass="72841" checksum="BBD56BBF81131E71" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNM0</accession>
    <name>A0AA38JNM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_995504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNM0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="133" mass="15484" checksum="6613DC10598A05C5" modified="2024-01-24" version="1" fragment="single">DQDEIINMSIFNQILELDEDDTHDFSREMVEEYYTQAAQTFDDMDAALMQKDLEKLSDLGHFLKGSSATLGVTHVQSSCEKIQRYGQLRDEEKGIDIDNEQALNLITQLISQVKGEYSVAEKWMRKWYTEHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNZ7</accession>
    <name>A0AA38JNZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1144086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNZ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="247" mass="28011" checksum="A13169C7B9E9FD58" modified="2024-01-24" version="1">MSIRLVTFDVLHTLITPRWPIHLQYAMVFEPYLGQLDPDSIKSSFKTALKTLQIEKPAYEQGSQSWWANVIKRTALGAGANPQLLDTSLGVIVPKLMKRFSSKEGYREFEDALPTLRALHERQTYTAVISNSDSRIRSVLTDLKLPDYMIPIVLSEEEGIEKPTQEIFLRTLDRVNNMRGERIRPEQCIHVGDEYDADYHGAMKAGMRALLLRRIGPDGKQAHIDVGEDLNGVEVIQGLDEILDHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP07</accession>
    <name>A0AA38JP07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1038972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="338" mass="39814" checksum="5E374BCB9D8AAF17" modified="2024-01-24" version="1">MRSLPKFKTIPKNHTFVAYTNLFLTSIPAKRVQNELYARALHRDPRVMYGMIPGLTKHGDLGAFVLIEEHFEKIMKYVAQKNWDAVYVLLDGFIIYIHRPCPAPTDTSGIEREHGLLRLHGACLMTMFRELDKQGRLNTQNFPGLEYFLRYTIRWIEHAKDRLVGIFHLGSDILPHLDVCKAIAYRLFENQTVEDLNLHLTRIREWVQWLEPRVTESDHDDYAGTKVWVQDCLIREWPWLLLGVKPWYLEGRDHDVSKKGLELNLEEEWSTFSDYRKENPLVPPKGLSWEFKDWSEEERDAHRGGQVYEPSDEEEGDDDDSSDTESMGWGMERSFWKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPN9</accession>
    <name>A0AA38JPN9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CobW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1068361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPN9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="33"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="10">
        <location>
            <begin position="350"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3733296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="414" mass="44925" checksum="5275F22A85C1A4F3" modified="2024-01-24" version="1">MDSEADDDIPELISAEPDEQSSSDKNPIAKRVPLTIICGFLGAGKSTLLRRILTERHGYRIAVIMNEFGDTADIEAKSITVDGESTTLELANGCLCCSIKDSGAAAIESLMRKQGAFDHILLEATGLADPGPIAGMFWHNEEYIDARSIGSENGIVLDGVVCVVDAVFGLKQMEEDHADKEEGPGESLRQIAGSDVIILNKVDLVQSSILSATELAIKHVNPVAPVYRTVRAELNLGHILGIQAYSIGQRHLSALKDQHELQHDHDHDHDHNHDHEQGNNLSSSVVPHYVTRGISSLQVSLPPLSATQFAAFDAWIRTILWENRLLDSVDCLASTPDSQSKKSPLQGNINVLRCKGLLILTSGEQHVLQGVRNMYEIIPVDESMKSEFPHAGKVVLIGKGLGEDVRHSLLSAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPR9</accession>
    <name>A0AA38JPR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1065144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPR9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="32"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="623"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3733900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="709" mass="77941" checksum="D3305FE647B89668" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ16</accession>
    <name>A0AA38JQ16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_66789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ16"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF57">
        <property type="entry name" value="ZINC FINGER PROTEIN 154-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="373" mass="41707" checksum="A6E4271B16249393" modified="2024-01-24" version="1">MPRATSFKFIDESARECKECNLVFDYPHLMRKHMRTHEHVKSQGNFRCSWPGCSFTSPRRSNFDTHYRTHTQEKSKACPDCDFRACDPASIFRHRKRIHKYIPSARKGRAASHRSVSPASASTSFESVLDFSSFPSSSSSTSNSESSPSEFSSSPSTLSSASNSESAPSDLSSLSSSAWETNSSTIDPDYATYNQIPLDLDGLFNQPDALHCFEGTGLNWDEKLLGVPCPRPLFPAVDSTPSLEDINPTFYSKSESWSDLSLFFGNPSEPLAYSEITTSFQSAQDTNLWQNMNVSTGQNFDQAHHLQSTTYDACTGVLQKSTLPLPWPFRRNTFRSYLALKMTTTLSGPVQDFLMSLRGPTLQRSTRHMDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQM1</accession>
    <name>A0AA38JQM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1193623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQM1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42533" checksum="6E557221967E394F" modified="2024-01-24" version="1">MKGIRTGRPRNQSSSTPHPRGCLPTTITATKTPYSLCYYVQEDCVAVSSIGLYRERFLLLKKKKKKKKQKLMSKDCSTSVPGISLQRRFPNEISDLIVGYLVDDLPSLRNVALLCHDFANLSRSHIFGQVDLKDVSNGTGYFQSKSRSSGHRRDDYLPLMYRFAALLNDPKTTFLGRFVRRLNFDPCSGPLRNVEQAGLDLTISSIFQQLPLLTELSINRGRLVHLAAAQMYLSQQLKVLRIGHMVFHDQNGFEQLQDLLTSLTKLTFLAIHDWSLGRPLDIGTTSARTLILPSSLKKACITGTDEHTLNALGLGLKSPQAPVLSSFFSDFRNEVEDRSKLWTGIGSHAVVVLDVGNTMYWPGNLTTWKSADPVASYIPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQP2</accession>
    <name>A0AA38JQP2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_531133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQP2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="126"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="301" mass="33323" checksum="02459EB94FA5C0A9" modified="2024-01-24" version="1">MVFIGLGIRVFTCTTAPMHDHNNVAGNLRKTNASDQSGSSPVVRVRVFRKSDSEVVRRLFKTCLLTGEGAPPRAHLAATIKSPSFLCALTFFIMSVMITAAMIFNSEPASHILSGRSSAAKIRLVMVISSALLALWYLCYSIYSHYNLHQVKSSSDKILEDSTDPELRPMGIKAFWVAETVSPVTKKTEIVGCISLGDPPPPPFTSEPGVRVAELCRMVISPHHRRQGIAGALMQACEAHAMANEHKLSAIVLRTTFYQPHARELYAKLGYRIVLETNVRFGNADVPVYLYRKDFMGHKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQW7</accession>
    <name>A0AA38JQW7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1048938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="853"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1463" mass="159217" checksum="A888563700E391B7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRB5</accession>
    <name>A0AA38JRB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1055918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRB5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="262" mass="28532" checksum="7C6D092A32B4F076" modified="2024-01-24" version="1">MSRRYDSRTTIFSPEGRLYQIEYAMEAISHAGTVLGVLAKDGVVLAAEKKVTGKLLDLSGAKEGGYGGSGEKIFLLNSNVIGGVAGLTADANSLINYARSAAQQHLLQYNEDIPVELLAQRLCDMKQGYTQYGGLRPFGVSLLYAGYDQQHQFQLYHSDPSGNYSGWKATCIGANNGTAQSLLKQEYKDDIEVKAAISLVLKTMSKTMDSTTLGSEKLEFAVITLDPETNLPKAKIYKPDEIDELLQAEGLSKKEDDNAMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRH6</accession>
    <name>A0AA38JRH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">DFJ43DRAFT_1061389</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRH6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3734740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="84" mass="9282" checksum="FAAF65FE2DB335DE" modified="2024-01-24" version="1">MASQVLPLELIDKCIGSRIWVVMKSDREFTGTLLGFDDFVNMVLEDVTEYEMTPQGTKKTKLGQTLLNGNNICMLIPGSDGPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRS1</accession>
    <name>A0AA38JRS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginine methyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1056796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRS1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RMT2" evidence="5">
        <location>
            <begin position="138"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="375" mass="42287" checksum="759F2F5BEAB12717" modified="2024-01-24" version="1">MDLERSESEETVHIFTQLGEHLIDSILHGESFDAIKRIVQEGAPLWYQNESEGMSALHAAAYVQNPELVQFLIDEGAIWNSVDNLRCTAADVALSFNNETIYTIIRNAGIRAEMLLALLSSRSETEGPSSLVIRSEDVTAAASTDAFLKSRLKFVKDKNGQEICVVKAGDEEIGVMMGWEQDIMRETVERLCGDHPSSENLKVLNIGFGLGMIDSLFQALPTRPVTHYIVEPHPDVLQHMKELGWYQKPGVRIIESKWQDSIQELLEVGGFDVVYTDTFSEDYNALRGFFEHLPDLVAGPESRFSFFNGLGATNVLFYDVYTHVAELHLADVGIDVSWKDVRISDDKNLDRWGKTREYFSLPSYRLPIGRMSKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS03</accession>
    <name>A0AA38JS03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">DFJ43DRAFT_1074429</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">ET3784</strain>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS03"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="27">
        <location>
            <begin position="58"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="26">
        <location>
            <begin position="203"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAJ3732248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1068" mass="112354" checksum="4DC1529B21652EC1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSF3</accession>
    <name>A0AA38JSF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_705527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="192"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="319" mass="35714" checksum="5D745EA0473F4CBD" modified="2024-01-24" version="1">MSSSTSISGFTQIAISYSSSSTHYIFAKAHVSSKKSTSSWPSGRTLFLVNVPPDATERDIILLLKPYGTVENVLFDSDSPIQGEEDGASSDSEAEEDEEQEEGQHDNDDIDASQPRKRRKLTTKKLEPPKVFPLPSIPLRKLRKTGQTAHVIFLDTSSVDRFFSASHAKPRPWPSSSEEPSGLSHYLALYDSLRPPLDAVRQHANSAMDLYEFELAKSKRESKYKKGEAIVDEDGFTLVTRGGAYGRTVGGGVAVATKKFQETGETSERNKKPKKEKTSFYAFQKAEKQRDELIQLKKNWELDKAKVEKLKASRKFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT64</accession>
    <name>A0AA38JT64_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1154146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT64"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="314" mass="34244" checksum="18CDB4567217454A" modified="2024-01-24" version="1">MTLPHRSSPNDDESIEDQQSSSFASASYPSSTMPGAFTECDNCHTTTTPLWRRDRTGMKILCNACGLYSKTHNGSDRPLNGKTPSERRQTANKSKQEQVESSPPQECSNCSTSTTPLWRKTDEGKLLCNACGLYVKLHGHNRPVHLRTDVIRQRSRENARVRVKRANTGEITAPASRNLSRTRSSTAQIRRHSALEDDDEDTDEGSDEPGYRSIGTQRDSDSEDSDSIGTPDEGGADSVLPPKYGFLKNRFKRQRINIGDSDTDSVASMGSPSLSSLAAVAAAVAAGAYPDSPLSLSPIGATFAPRPWLQRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXX2</accession>
    <name>A0AA38JXX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_264479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXX2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="220" mass="25436" checksum="C448789A42A2B383" modified="2024-01-24" version="1">MSASKEDLRVSIETMSDWSRVKASYAQAARSLLAKELTARNLSESSSLSQHLDQFIQNTFRLVQPNLRVNGQDFDERGEDGWFGKPHIYVDTFYFFSFDIDIELFDESLDRHVWSLHDQRLGLQKTIAVTRRIEPSKIEKTMLGSLEQYHKLDALESELEDLPEDLTMDVDDTAAFRPEVDALLRTAAWAQELSQSIPNQTERTARLKNVTAELKRPDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K2P1</accession>
    <name>A0AA38K2P1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1148958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K2P1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="604" mass="68893" checksum="16AD0E914EB8FD52" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQ97</accession>
    <name>A0AA38MQ97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1009548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000188">
        <property type="protein sequence ID" value="KAJ3709435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQ97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="120" mass="13406" checksum="73D5D9AE06889709" modified="2024-01-24" version="1">MPQHVFRNLVRDLVRCGLSSSRYVTAEEHVAIFLHLVIFGNGQREAQERFQQSADTISKAFHCVLGIISSPPFYTHFVKLPNDTIPHIIQSNPKYAAFCKAQAAVDGSLADAFVLEEDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU68</accession>
    <name>A0AA38MU68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1161970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000128">
        <property type="protein sequence ID" value="KAJ3710902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="534" mass="59431" checksum="41411C5F92118278" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUJ9</accession>
    <name>A0AA38MUJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1153530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUJ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041287320" description="PEBP-like protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22433" checksum="6889A817A5FB39B9" modified="2024-01-24" version="1">MHRALLCVVITLFGLLSIACAVPLQDYTGTQLVSRTQVTASEAPLTITVRFPRDPNNQHAVVLTKDPPPSEHKPPEDQLRAFHKWFSEELNKKIRLVVTNSLNQKFPQAHIVFDPSFPFEDYEWTPDNGRPFHLHLNTVEMISGKAVSRDFVGTMKEVGTECMGSFVRDDLSGNILFPTSKEVEDVKHSPLTVTKAEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUU7</accession>
    <name>A0AA38MUU7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1105936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000105">
        <property type="protein sequence ID" value="KAJ3712771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUU7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF10">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3712771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="187" mass="21840" checksum="FAB08BAC64129B82" modified="2024-01-24" version="1">MVNSYRLKTVIDLRTKSEVLNRKNISRNQEKGPSCGEKRWNTVKVNLIGRKFEMNLVQQLRWWQALWFFVLMLLQRRMTAIRIIGRNVMSPKGLVGLNKDSLQFCQYGILQALEVYLDPQAYPVLVHCTQGKDRSGLIIMLILFVLRIPLKFVKADYVLSNQGLDRVRASMIKEVLEIGIILKHRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV57</accession>
    <name>A0AA38MV57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1008229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000101">
        <property type="protein sequence ID" value="KAJ3713231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV57"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="109" mass="11803" checksum="FA137467F39E4959" modified="2024-01-24" version="1">MANDSSASDLMHQMYIDAFNGTSDSLRMAMVSPQVVQGTKSTWYGAGGSSILGYSNIPTVGIIPQPDYLWASMVDGGWSRLDIPEAIEQINVILRLLTMLDDAFTSGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV62</accession>
    <name>A0AA38MV62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1044001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000100">
        <property type="protein sequence ID" value="KAJ3713261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV62"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041264420" description="Wax synthase domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="6">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3713261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="313" mass="35565" checksum="38F8B05EE787705F" modified="2024-01-24" version="1">MNYIYATSSFCLFFHALDFLAITDTYAELRLVGQMKSPLSMPFLSRFWWSWKLILTPRGIGWTHEPTNVIPPRPKSQSRISFIISQLPSTIILIFVADAANLLLRSHPGFLPGGPSIAEVGPLMRYMNVLLFASSSFYALQLQYKLFSISVTAIGLSHPEHWPDLMGFWSDAYTIRRLWGRTWHQLMRRWVSAAVRRLFSATSKLLGRWKSGFFLSQAVAIMIEDGVIALGKRAGVRDGTFIRSLGYLWTASWFAFCLPIWIDPYFHDGMATSKLFSPIGGLWKGDWTVNTQITTGSLQPHTNKDSISRLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVD4</accession>
    <name>A0AA38MVD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1106850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000111">
        <property type="protein sequence ID" value="KAJ3712122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVD4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="818"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="897"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="668"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="784"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3712122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1234" mass="134972" checksum="B308FFB36D477EA2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW91</accession>
    <name>A0AA38MW91_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1043433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000081">
        <property type="protein sequence ID" value="KAJ3715974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW91"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3715974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="220" mass="25070" checksum="BA9B287771A1A8B3" modified="2024-01-24" version="1">MTRPEAESALETLYGDAVVDERWTPILNEITDLEPDSDMTPILSRIDAHLTQNSSQTPLNITTPPKDSRLQSAEKELMDHVQELRKRNRIHGQPFTVDEIIDPVEEAEIGEEEGRYGENAVEKIVKQVRYEQAVKNGEIIEVEDEDENEQDAPPDISLRDLVATCKTLQTQCLTRNLEDPKLAEQGMELMEQIRRFQGAVQKYSAKNAKQASLDEFFSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWC2</accession>
    <name>A0AA38MWC2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1159299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWC2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="1">
        <location>
            <begin position="42"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="204" mass="23073" checksum="F4EFA3AC950858FC" modified="2024-01-24" version="1">MNSATEENSKVKYQGMIVGTAGVGLGMVVTEINKDIDIRDQLMSYGISAICLDIGREARIRTSEFFKIPGLLTWNQIISSVTWLLKDRIFHHGEVDLEKRTTNGLPFQSPLLGVMLRGYLMDGKPKQDWLLIAKLQREERIPIPFIAMLTILIQHALQEFSSGYKIDNPLSNTYLRSRYHVVMSTLTALQEKAPDYVDLSQTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWI7</accession>
    <name>A0AA38MWI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_991138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="111" mass="12299" checksum="18FA2A435059A9EC" modified="2024-01-24" version="1" fragment="single">MPPSSEQESNIHSIGPGAPPSSVPGNGFAAITATLTHTPIPESEIIYTEDAATKVTDRIRRRCYNCYTSDTSTWRRSNLAVGKVLCNKCGLFERTHSRPRPEQFPHKRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWP9</accession>
    <name>A0AA38MWP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1092334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWP9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3722784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49503" checksum="8EC1939A022F26A3" modified="2024-01-24" version="1">MQDQALPRYSVVSKAPPHYSTVSPSPALDHYSFSLKSSKGNIWASVNLPKKDHSRSYSVNDVPIIGEGASLIIGSVKLNLKTPETIQRITMTVRGRAITGANEGGSHIFLDHSVSLWSKEQGEPNAYRNDLTAVAGTSTSSRNGKLLGSYTFPFSISLPTGDADGVALPETFHERASGVRVRYELVLKIGRGRLKSDSKLQIPVVYHCRTTPSPPSILRQHAYQENTTAPGPPLDPDGWSTFSPVDCIGRLLNSRTVILRCTLSLANPLSYTRGSFISCHLRVESIDEQALDLLASPRTTVLRLSRRVKYLFDAGQGMQHNGKSTASVPRYEILDVGQTIWSHDHDINEDDSRVRYLTGEIPLSKELPPSSDVSSFGVEYAVTLLPFESATFRPEGATMLQTHKVQVVSDFAQGPVPSRRVPISQIEATWAASARESVNAIAASHSNPFQLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWY7</accession>
    <name>A0AA38MWY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1133606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWY7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3724187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="363" mass="40770" checksum="4A33866F71A4BF71" modified="2024-01-24" version="1">MVGGCVTASQMRHLWKSQSSQSRPLSPAEEEAGKAAILEKVMKGRQPTDLMLRCTILDAEGNVKTISGQFKKSDLSVEHQLNPRDLRKIDSRVPNLVPTILVRKQAILINILHIRALIKADTVVLFDTYGSADSRLHSVYLYHLEVFIRTLVGGLLAELEDSIDHDRFKRLLHYSRRLASFHNRAKLVGEAIDEVLTQDEDLSAMYLTDKHNGVEHDPLDHEELEILLESFSKQVEEIVNEVENLEANVQSTQEIVELILDSNRNALLALDLQVSIATFGVGTGALLAGLLGMNLTNHFESHPYAFFAMTGVAGFASFMVAFLGFRKLVKMRKIGLSQPSSDSKPRRPWLPLPLRRRNPEGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX67</accession>
    <name>A0AA38MX67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1157948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="952"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3724111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1417" mass="157280" checksum="D387304FF3518E73" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXJ0</accession>
    <name>A0AA38MXJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_640410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXJ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36677" checksum="125C6CA152CB9A93" modified="2024-01-24" version="1">MAPRFNPKRDLVDLHGRVIIVTGANRPLGLGYSTVKHLASAGAKVYIAARNEQQSLQSIEKLKADLHLDPSDGNSGQVHFLKLDLGDPRDVKKVAEEFLAKESRLDVLVNNAAMVFAPFEKTSDGISKIVVTNLISPFVFTQTLLPLMAKTAQEESSDTRIVNVSSITHYIANIKKLENVEDLNQEYRRRPLAKFTRYAHTKLLIIIWSRALHKYLSSLSSTMPGVERITVMALDPGNIDTFSNRWPLPWLWRPFVRLLMTAPNVDVGAYPTVFAAAGKAIYTDRGKYAGRYLNEKMNVVNPSSNARSDNLADELWTLVEKITNDMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXR3</accession>
    <name>A0AA38MXR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1094840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXR3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3721368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="350" mass="39571" checksum="0DCF7133B26E81CF" modified="2024-01-24" version="1">MGQEKRLIAAQSLQALFDSTNASLAIIRNVAEFSTHKVDEGDVSDVEDIDTRDPAIVTIDVASQLSYLRKLKQQYLEQNAKDKYVKLIVTDIDDPPTVTDSDNKQLEKQNIEQKEKLKVAKEKLSIIEGDLRTVSSKVEEDYVRVKQATAKATDLAQKIIDARLALSRLRQTHPHPRVTVQTADKKLEDQVMEMQALTDEMQAVDQKVHDMKAKLKAASLEAESLKTQRNEVEKNVKKSESGINDDRRFVPLYDWLTGSLSIHRSMQGLENIKAMSENELRLQYSVENKHGSFRTISITLIFVPNSRLLASANVQGMEGVDFSDVIEAHLQMNNIRGMLAAILARTREWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXT0</accession>
    <name>A0AA38MXT0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mis12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1048177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXT0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3736859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="285" mass="32331" checksum="30E2B9A2F2C85AF8" modified="2024-01-24" version="1">MSNPPLLLPEALGFSPQLLLDDIINAVNNTIVEGVNAMEDFLRQWADRRAEEERDWDSTEELEQGLVSFETLLEHHTDVALDFFEAWALKNIFSIPSDLPVVLPHQKSLDLRAKPERETDLVEEISELRAKLDNQRRLQRLYSRALRASKQQRLRSERRLERLSAVLDREKLESLAKVPPQLNAMYEAVSNLPPLDPAFVATLPLTEPGKREWETSKVGYLNWATAQLLSRAGADESAQGSSAVDEMFRNMARIGQADQLRKAVEITESVRTGLQDVDAMETEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY55</accession>
    <name>A0AA38MY55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1084199</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY55"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="451"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="653"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="827"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3728988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120940" checksum="32D5CD66BB1E64BB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYR3</accession>
    <name>A0AA38MYR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_435348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYR3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="240" mass="27061" checksum="C431B87A35372EB3" modified="2024-01-24" version="1">MSFFGRRPKRSPTPTGSLSRQNSLTEGDAANAKPLYLCSPFADAALVNGNFKTIVMLPKYVDVMEWVAVNIHDFYTNLNEFYGCIAECCTQSSCPTMSAGSSLNYLWTTPERKQVSLSAPTYIDSVMSSVQNLLEDESVFPTKSGQEFHKESFPVTVKHIYRQFLRIFAHIYHAHFPQILHLRAEPHFNSLFAHFLAFGREYQLLDEKDIRGDPNAPVGVGLLWERWKSSGKLEKGAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZJ0</accession>
    <name>A0AA38MZJ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_472715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZJ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3729964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="283" mass="32177" checksum="B6F234B4097B5DA1" modified="2024-01-24" version="1">MFSNLFRSLGTATHNLPCSAIKQSSRGYGSGTIISNSVRKPKIRKYAVETGRRLRISKSLSWLLRHQGRFEGIHIRSDGYARIQDVLKHQSMRNVEFLDIENVIKKDSKGRFTLTYEGDRSEGDHWWIRANQGHSIEAADLELERIGSADRIPVAVHGTTEEAWKLISKQGISRMTRNHIHLAQGFSEGVDPKVFSGIRKSSRILIYIDVEKALADGIKFYLSANGVVLCPGDEYGFLEPKYFQRVESVTKTLEPVQEWDRQVAETSSTIDPTEDRLKAWSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0D3</accession>
    <name>A0AA38N0D3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_345741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0D3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34978" checksum="1D8103EF925106BE" modified="2024-01-24" version="1">MMTYPVLHPPIPYADHHFTFNPHLRLSDRYHDWDPSNQSVPSEKPSPGLLAARETDGLLRFLDEFDHREIDQSPWDVKPEPVELDTTWHSLDNVQQHQHGGPSNTNLYSDSHTNHLAPQVSVVRRRSFPMQESDSHRMGRLSSRSHNVGQMNTSRSSPMNRTPSMQFAHLNLDDVPTSPDYYARRASLPSGSLVSRPYHTSYLPELPLSRTKPLLSTPQKRLNHIMSEQKRRNAIRDGYAQLIALLAGPEGSHSALVMPTRGRPKGSGVKGKQAAKNGNELIEGRRVKVVFCSALLNIATGWKREGMHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0H7</accession>
    <name>A0AA38N0H7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial ribosomal protein subunit S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_287187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0H7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="153" mass="17559" checksum="C84B32F9EA013D66" modified="2024-01-24" version="1">MLPHELCSHVQNAFRARHAKIFVEHNTQNLGILSILLRAGFISNITRGTITSPDPIEFHHVPEPQRRIWADLKFRNDLPVLRNMELVSKPSKKVFMNLGEIRRLCSGRRAASVPPLGMGEIAVVRTRNKEYQWLEAREALQMKLDGEVVCRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1M3</accession>
    <name>A0AA38N1M3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1072072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1M3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF294">
        <property type="entry name" value="POTENTIAL PROTEIN LYSINE METHYLTRANSFERASE SET6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="4"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="347" mass="39828" checksum="F455AE03F961BAAC" modified="2024-01-24" version="1">MANPSFIQKTTPHGGRGLFATTLIPKDTLLMSTSPYASVVYRRYRKEVCAQCFSYAYEFNRNTWKVKYELDGSSSHFCSEICKDEWQSRHNVDNLIAIANAALDRQEKTMKKPRSTRETQNVSFPDSTATITMVEIDSAWKKVEETTINVVLKEPLDELELDTARFLASAIVRRHLETTTSSSPDSCTTGTWSQVLQLQDNELVYTQARPYALASHLCVYLFLRRALWFSIPILRPYLETSDTVRDLLARDQGNAFGLFEVAGDSEMLGYAIFSLGSYFNHDCSPNVRKERQGQSMAFYTMRDVQPNEELCINYIDIEDAVNVRRESLAKHWFFDCLCQRCNIELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1N3</accession>
    <name>A0AA38N1N3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_145962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1N3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="893"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="966"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1217" mass="132219" checksum="6D2C6C32114A0DBB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2H5</accession>
    <name>A0AA38N2H5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1153066</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the BOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2H5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3733443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="244" mass="28106" checksum="7EF23082BC7ED60C" modified="2024-01-24" version="1">MNSLYTSGVRQTNSILADLERLRTGDNSASLLGQISASLAAMHRTIDDYDSMAKREMIKAKQEKAHMRVQKFRTDYTEMRNQFERLKAEVNAEKEAAHRAELITSTSLASPSANARQRFQTTYSQNNTLHPELLSESPFRGPSPQPGFNLREQHALNEHSFIQQTESRLDEFLLQGREVLDNLKDQRNILKGTQRRLLDTANTLGLSRNVIGWIERRSTQDMYIFFGGAIFTFFCFFMIWKYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N378</accession>
    <name>A0AA38N378_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1063890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N378"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3734178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="174" mass="18382" checksum="CA0185173CFFA13C" modified="2024-01-24" version="1">MPPPKSKGGKMLSLINWRLKVTINDGRALTGQMLAFDKHMNLVLAECEEFRRVRPKKKAGDESAPAEQELKRTLGLVILRGETVVSLSVEGPPPVVDDDKKNALPVGPGRGMPAGRGMGMMPPMGAPSMAPPMPFPPGMPGPPPGFRPPGFPPGMPFAPPPGFAGPPPGFQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3K9</accession>
    <name>A0AA38N3K9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1151846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3K9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="59"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="543" mass="57813" checksum="43EB9829A61F17E5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3R7</accession>
    <name>A0AA38N3R7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1051468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3R7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="580" mass="63660" checksum="764B3A52B9C41EB3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N507</accession>
    <name>A0AA38N507_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1045732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N507"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="182"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="315" mass="35654" checksum="FC6C5C5C6E700CEA" modified="2024-01-24" version="1">MALDSVPFALGPTYGAYLWSAILCTSFWAITCVQVFIYFMRSSKDSKLIKYMILSVWALDTIHEAMIVGSVHVYLVTNFGDFQSFMTVIPTMLLEFLFQVIASTITQGFFVWRIFQLSTHYSLWSKVKSMRWLAFAIWVPFGCLQIGLCVLYIVKGLQSPTVLTLVSPFFYNQTIVYLVIASAVDLALSLTITVILYQLRHSELSQYSSTSSALKKLIIISINNGIWTALFAILDLILYVAYPTTTLYLIFDFTMCSLYTNTLLANLNARDYVASCLATEVMMSNNMPASSSLEFPNPLESSMRFDDRSKAKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N565</accession>
    <name>A0AA38N565_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1164253</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="911"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="237"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="582"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="916"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1190"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3737806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1450" mass="162332" checksum="2AAC6507F50EE05D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5W6</accession>
    <name>A0AA38N5W6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1035252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5W6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="244"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3737567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="422" mass="46133" checksum="DDCA6CA676A99C8D" modified="2024-01-24" version="1">MFAGSPLNRLSWLRNSHSFLNSIIASPKSRWLLFKSGNPLTTKTEGKSILAYLSTKDVSPFIGQAPHFGQGRESGLLTSEEQISATEAVRHRGSPIVFLGLHENTSSGSGALPSSEFVDADKAVAKLEGVPYFAMDISDLELEEPAIQATLNETEAVKAGTSLAWLDARSVMTNADLFDGAIFAEARSMVDWNTRNKFCPGCGAKQHSLWGGWKLGCSTLMPWVDNAGRKPCPSGKGLHNFTHPRSDPVVIMLAVDETGEKILLGQNNRFKGQFYSALAGFIEPGETFEDAVKREMWEEAGVKAWDVQYHSGQPWPFPASLMCGFYARADSTQPVRTDLDNELSDARWFTRQEVMSVLTHATGSYLDLAKLAEASSQLNKDANEPPFRVPPTTAIAGVLIKDWAEGKVQFPTFSVNSPKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J219</accession>
    <name>A0AA38J219_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CBD9-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1216198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000098">
        <property type="protein sequence ID" value="KAJ3713490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J219"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="100"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3713490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40515" checksum="83E5BE374D99269B" modified="2024-01-24" version="1">MIPGWMGVGFGSQMANSPMVILWLNSDGSITLSQRQAPAEVMPAVVTSPLRTASLLANASITVGNNTQFVFSIPASAANTTTIPTIWAFGPQNPGSSSSNALLQIHEETGIASFDLSKDFTGVASPSSALMPFQRLVIAHAIMLTIGFLLLLPIGVLLARYMRTFTPIWFKGHWFVQFAVSGPIIVVGISLGFQAVVESGAQHLNDEHKRWGVALFILYLFQCSLGAFIHRVKFANILGRPPQNYIHASLGLFVVGAALYQVRTGYKTEWPKIGRGPLMAGTDYIWYIWVVMLPLLYAIGLAFLPKQFRQENKPKKENYAEMFDVTAFREELELEHAMDSQISEMMAEEHHDMMAEEARPTLSYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2T5</accession>
    <name>A0AA38J2T5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1161381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000106">
        <property type="protein sequence ID" value="KAJ3712747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2T5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="297" mass="33933" checksum="5E35D1A393C25258" modified="2024-01-24" version="1">MQTPIRERVGGYSDFFSSGFRAISLNDSPSRPRKSSLYSLSSIPSDLIHSIPSTSRRRSVVDDNRRRKPMPWSPKSREESHTNLLTTEKRKKRSSFIEFSAGLFEKMNPGVLQPRPRSFVEFDNNQNRLRLHSRNGSSGREKLDMSGLIGTHVSSIQTCYPDANERDPFNPSPHSESFFIDLSDSSSFSSSPKRSRHQSFISFSGASVSTLNRFTRRERPASIHSLPTSDLLSSRPIKTRHPFSRSPSYQHPTNLDKADSILQEKESSDPESPYEHGNRDLADIDWREFHIQLYDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3T6</accession>
    <name>A0AA38J3T6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1102485</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3T6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000096">
        <property type="entry name" value="ADP,ATP carrier protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="115"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="216"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3715226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="281" mass="30153" checksum="C98F05B94E375DF4" modified="2024-01-24" version="1">MADKKKTKSPKDFAIDFMMGGVSAAVSKTAAAPIERVKLLVQNQGEMLKQGRLATPYGGVLDAFRRTIADEGALSLWRGNTANVIRYFPTQALNFAFKDYFKSLFGFKKEAGYWTWFAGNVASGGAAGASSLLFVYSLDYARTRLANDAKSTAKGGGERQFNGLVDVYKKTLASDGIAGLYRGFVPSVIGIIVYRGLYFGVYDSLKPVVLVGALQGSFLASFLLGWTVTIGSGLASYPLDTIRRRMMMTSGSGVNYKSMFDAGSQIIAKEGTASLFKGAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3W1</accession>
    <name>A0AA38J3W1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">agmatinase</fullName>
            <ecNumber evidence="2">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_777344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3W1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041241532" description="agmatinase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3718106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="423" mass="46027" checksum="B7C3743C6A4E90B5" modified="2024-01-24" version="1">MKLSIPSVLLSVIAVFASERQHGHDHDHGEQMPLDYVKFPYEQPLYRTSTGEVTADAIFSGITTFAKLPWVQCLTSQRDVPVDIAFLGAPFDTGTSYRPGARFGPSGIRAGSRRLNLYGGYNVPLEANPFKSGYRIVDCGDIPVSPYDSAYAVKQIEAGHKSILQRAAFMPAANDSKTGEPLDAIALDGKSHPRIITLGGDHTITLPLLRSINSVYGPISVIHFDSHLDTWKPRVFGGAPSDTAAVNHGTYFWHASQEGLIRNGSSIHGAIRTTLSGLEDYEVDDEVGFQRIEAREIDTLGVDGIVKKIHETVGNRPVYLSIDVCLFCKYSSVLEFKYQIDSIDPAFAPATGTPETGGWTTRELRAILRGLDGLQIVSADLVEVAPAYDTNAELTTMAAADVLFEVLTVMTKNPLGKVKAKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4J7</accession>
    <name>A0AA38J4J7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1126401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4J7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="695" mass="73391" checksum="613A478807168078" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J562</accession>
    <name>A0AA38J562_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1009308</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000142">
        <property type="protein sequence ID" value="KAJ3710255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J562"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3710255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="143" mass="17123" checksum="88607050C54C210F" modified="2024-01-24" version="1">MIRFILVQNRQGKTRLSKWYVPYDDDEKVRLRGEVHRLVAPRDQKYQSNFLQFRNYKVVYRRYAGLFFCVCVDANDNELAYLEAIHLFVEVLDSFFDNVCELDLVFNFYKVYAILDEIFLAGEVEETSKDVVLTRLEELEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5N8</accession>
    <name>A0AA38J5N8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1128225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000115">
        <property type="protein sequence ID" value="KAJ3711838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5N8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="148" mass="16974" checksum="AAE15CEEC3A62FFD" modified="2024-01-24" version="1">MAGGKGGRPKKRARNISGLNNQSKQKSSDTAETRDHDDMDEDELGNDSELPEELEDWIACEKEEDSEDEVEEYEDDNLNDEFFGGEELQETLFEYAGAMDTDIRDEDWVPEWLKRKKKQRQEREKRGRPSSYSIGPESAVLGMGQIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5T6</accession>
    <name>A0AA38J5T6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1004602</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="13">
        <location>
            <begin position="1246"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="1972"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="2335"/>
            <end position="2363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3721360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2363" mass="268500" checksum="97D82F6E32A4875C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5Y2</accession>
    <name>A0AA38J5Y2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000189">
        <property type="protein sequence ID" value="KAJ3709419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5Y2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115741" checksum="E34BC865BB6C16B6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J623</accession>
    <name>A0AA38J623_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1002163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J623"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041310208" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3726355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="565" mass="61496" checksum="4D0DB227DCE25E58" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J679</accession>
    <name>A0AA38J679_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1158435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J679"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="96"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3722163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="394" mass="43809" checksum="FDFE07F235BE4C62" modified="2024-01-24" version="1">MSNSVFKSNTASSNWLALQKNLNRQSTRKNESIHKRRKINHYAEKSSPSSSSPSITAKALGDDSNDHKKNGESLLSLKRIVFGETEYSTEQKQPGKFIAIDCEMVGVGIDGSESSLARVTLVNYHGAVQMDEFVRQRERVVDYRTQYSGIRESDMQKAKPFDQIQKRVADLIQDRILVGHAVHNDLKACRNPIPTHSRRRSSVLARDTQYLAGKSKVVRSKYVALRKLVEQELGIVIQAGEHSSLVDARATMAVYRLHRKEWDHGLNILKTSTSAKMSEAHDGDSNTVETQENEEFQNVKRKGKRKRTVDEEGVDVLNAEETQSPLRSHPKSEPLSGKQRGQPGVYPGGGRKGVSSGLSTIVRRGGSERGGQKTQWWKELGSSGSSGSKGSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6G6</accession>
    <name>A0AA38J6G6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1107300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000116">
        <property type="protein sequence ID" value="KAJ3711651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6G6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="73" mass="7842" checksum="CF9B5808C7C4030F" modified="2024-01-24" version="1" fragment="single">MSWKMHYNVAAGEALGIEADLHSYMANPEVFTVKDGYVAVLQGMNFGSVHSSVIVLRRVGVVATSSLSSRIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6K6</accession>
    <name>A0AA38J6K6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1157636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6K6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="451" mass="51694" checksum="2A0A68D03FD28F6C" modified="2024-01-24" version="1">MLPDELLHSTVEYIAYTPEPPDCDFLGFHFKSVSPALLSLSQVNRRMRRICVPFLFSYLRVVNVAEAMKLMDLCRTGSIIPSLIRVLLLSASYYAQKEGHKILRQVLPCLHHLSCIHLRIPRPSIDLFTTVLEQPTVSTVLMRSLDNLPGGFSKLNLSKLVLKHTSVAFPRFSTLETCIRRGARMASLDIHRPDLLDESFGPRIFTGLQELNLFVCYFPVSFSWLPAFASGHPSLNKMWLLDDKKHYFDRHTPYFIHSFVEGCHRQELSECFDITRVGLSRVNQSSQEWRVTGMTIVTKFASTSLIEILSLICSSFPAIEVLSFDLDRHKDTYHIDDIVSVLAGFSCLRVLYISHLYNRIESGRKTSWKLVRQLETNDVCKILAATAESAFLCYASRLAKEIASLAALHIDDMGYEHEKSRYGRRWWLKGWLHVRDSSRDIEGALRILTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6L4</accession>
    <name>A0AA38J6L4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1161830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000122">
        <property type="protein sequence ID" value="KAJ3711237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6L4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3711237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="158" mass="18014" checksum="8E2EDE4E886B9301" modified="2024-01-24" version="1">MSSMSLPSISEMFPIHLITIPPRRRLELMAGSNLKSRHTQQSANNSGSLPHGYSFVSTSNHAVSSDDDELDGENERHDQTKKHVCPQCFKRFSRPSSLRIHGNTHSGLTPFSCPYPGCGRRFNVSSNMRRHYRKHKFQPPGNDVKKLRPSYPPWPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J716</accession>
    <name>A0AA38J716_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_560791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J716"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041467986" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="538" mass="61135" checksum="B892E92D8493A1C7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7P3</accession>
    <name>A0AA38J7P3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1108220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000124">
        <property type="protein sequence ID" value="KAJ3711112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7P3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="70" mass="8066" checksum="C7D247218ADDAB54" modified="2024-01-24" version="1">MAIGRYGRRCVSTKRPSRFNVIHLSVIYVYHGGHLPELFSVAYIQSAFRYYPPEFIFCSGVSFIHLLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J835</accession>
    <name>A0AA38J835_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase, V0 complex, subunit E1/e2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_969307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000088">
        <property type="protein sequence ID" value="KAJ3714895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J835"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3714895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="61" mass="6633" checksum="E81A954E49A3C8C5" modified="2024-01-24" version="1" fragment="single">MPSVLPVLFGLVIAVVLMACAAIFTPKGSQQVLIRTSLMLALAACYLMWMVTYLAQLHPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8A5</accession>
    <name>A0AA38J8A5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1001458</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8A5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3728054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="561" mass="62947" checksum="D4F97C02B54807D2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8P3</accession>
    <name>A0AA38J8P3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_81728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000112">
        <property type="protein sequence ID" value="KAJ3712103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8P3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3712103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="106" mass="11640" checksum="A8A889DB8FAF50B3" modified="2024-01-24" version="1">MDFRVFVQSSLQPLLPSPERNLSVLLLVNRETPDPRATTPGTVKGTFWPTTVIYITSLTITGLLVPWTNERLLGGTSAAASPFVIVLDNAKIPGLNRTSFQSPLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J989</accession>
    <name>A0AA38J989_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1126922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000083">
        <property type="protein sequence ID" value="KAJ3715619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J989"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="444"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3715619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="809" mass="92022" checksum="A73927B654F62F4B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9K3</accession>
    <name>A0AA38J9K3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_347376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9K3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="501" mass="54800" checksum="7F943505D1F0D45F" modified="2024-01-24" version="1">MSSDRFSGPTSLRKGQACIYCRRRKMRCDGARPICGQCRKGQRSEDCEYTDRQGQSRMEALEDSIARLKARIHELENPVAPKDEAVILHQPYVGNASGLRPTLTGPSPGARYAVASTSPVEPPQEIVSTLLNNFFEHALTFGFFLSVSNFRASALLPYPMGDPRRPLSSLMTIVYFFGSLLSDNPVWQARSSEYLAQALESTGSSSLAGSHPHKVLHTIQAEVLLANYLFSAGRLLEGRYHISTAMSLCVGSGLNKIRSPNFLLMVDTSNGLLPQASGPSEVGERIMAWWVTLSLDQSWAAAFEVNSYNDPIIAETETPWPLRTEDYIRGQLIPNAPRSTLTVQGFLDGDNRDGSLQSSPLELAAKASLLWKQAHLLKEAAAVTNIASVSAATRDRIDELLAILNASHDRDPSDAPAFSLLLARGLAHAALISLICLRSSGVENLEKVINSSLAILEIIGKLEPQNKYINPLFTVNQIVFAHAWNLITAERRCYGLLPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9M4</accession>
    <name>A0AA38J9M4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1005807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9M4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="106" mass="12408" checksum="148828EDF0F368A2" modified="2024-01-24" version="1" fragment="single">FVFARIQGEICLVQVSSLTPTQSALTTVNVKIFRHEFITIFCFLVTTTLHPSDIHFIKNIDDQLVYYEEEKGTDFLARNVMERLRQLTLPVFPQPPRRVVRPSSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9W3</accession>
    <name>A0AA38J9W3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_804038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9W3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3716776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="154" mass="16662" checksum="73734B1F467722DD" modified="2024-01-24" version="1">MSATSPVRGNPSGSSGPPRMAPKTGRNTVIAMAFLASGFAGFFFSLHVRDDRRRKSGKLHQYEDAILTRPGEYRLNEAQAFESDSSPLASSIAGTFSTRAPRLPVYTHEAQHHARTPGWSTSDDGVSHSHHIHQPAPQRAKGDGSGHVYTKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAZ8</accession>
    <name>A0AA38JAZ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_745669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAZ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="415"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3719133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="799" mass="89480" checksum="9AD8B62AA5840683" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBU9</accession>
    <name>A0AA38JBU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1076534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="555"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="871"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="920"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1310" mass="146001" checksum="18ACB5E6C4A2725A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBX1</accession>
    <name>A0AA38JBX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1152643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBX1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041201142" evidence="2">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="83" mass="9336" checksum="22E3754307A1E474" modified="2024-01-24" version="1">MSKQVILLLFTVLLLGLFTSAAPTPVERKALKQLKLKRGGPEPFMKRDDAPKPSGYVAKRDEASRVVKRDEPSAPKPSKWYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCA9</accession>
    <name>A0AA38JCA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1009321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000143">
        <property type="protein sequence ID" value="KAJ3710242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="196" mass="22421" checksum="FBE52B48CA0AA3D0" modified="2024-01-24" version="1">MRKLERILNVIQDEDWSFGKFLYHFFRTKDEDGVEIKGRTKKHAGMLSIFMHGSTKYHTACILKEWIRNPIGIPDSSHDEYSDMFSVTKLFESIHHARPALTSFAAQLVKEHLLLTAKSIVSPNGGLHREQADQNEEVPILEGDVVAVSEKSTLEKTQSVIEKKLSLMWHYCLAVATPNRKNRLSRAKNPPKMVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCZ3</accession>
    <name>A0AA38JCZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1095136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCZ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="602" mass="64302" checksum="5036F0880F594D16" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD20</accession>
    <name>A0AA38JD20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_675038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041289976" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="16750" checksum="9217C8C174300BD0" modified="2024-01-24" version="1">MKSILILLSIFFLTVHSQTITVLSPSSGSEITPGQDVTVQLAFGNSLTGVEHVSAVIAMINCAGAPCPIDASDSLGIPLFAGNYTPQYHEQNLPPYENFTVTVPGTLAAGTNMLTVAHFMLVGASAVPVLQFDNVTVSTPPSASSTRRETLIRGRTVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDV2</accession>
    <name>A0AA38JDV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'-5' exonuclease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Werner Syndrome-like exonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_876400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="10">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3714616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="235" mass="26689" checksum="4139B793858E973F" modified="2024-01-24" version="1">MLSLPQGFKPTLLRGLDEVEEALEPLVELVDQDPNASLYLSMDAEWNVRRRLGVSILQLCPHMDPTVVYIIAVHRLSSLPPSLLRLLTSERVWKIGSQIKGDLTRLRKQFPSQLDDSIQFSIIDLKTYALAKGFIQPKQTGTLASLCETVLGVHLPKDQKTRANNNWEYPTISTSLLHYAACDVLASRRIFERIASENESYMMLPEKVEARQDGARSVQAQVLETELDIELYRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE10</accession>
    <name>A0AA38JE10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1144260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE10"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3735262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="480" mass="53158" checksum="4F59EB6A57C653BF" modified="2024-01-24" version="1">MTRPLKLAIIGGGPSGFYLASRLLSLFPESYADSLRIHIFDRLWAPHGLVRYGVAPDHPEVKNCTHKFDSAVTDSRLKFFGNVDITSIGDNTSLSLSSLKKNYTHLVFATGCTEPNMHLQLPRDKGIISALDIVHWYTRHPSNPAPPPLHSASHVSIIGMGNVSLDVARMLLCPPSLLEKYDVPSHVLDALRKSQVKHVSVIGRRGPLEAAFTTKELREMMNLPDVALRPLEESVSNVQARTRQQSRTLELLKKGSRAAFGTTLRTWSLDFYRNPLGVTLPNSESPSYSLSLEHTTVDPITRRVPVTSTLPTSLIVTAMGFHAESSSTAPYAQWYDLNQKHIKTLPGGRVSTTNLDSDEPKIYASGWAATGAKGVLASTMMDAYSVAEAILEDWTNLTPSSNPHSEPVSSSPWDAPPPEIMKSLSSPDSEITTYKDWLAIDAEEVRRASTEGKERERMDWKEAKRFLYDKGLRVAEEDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFC7</accession>
    <name>A0AA38JFC7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1088682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFC7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3725672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="918" mass="102096" checksum="06A655FEB3413C66" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG49</accession>
    <name>A0AA38JG49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1076678</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG49"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="347"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="446"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="544"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3731974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="697" mass="77451" checksum="1C0E09278DEEAF48" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH03</accession>
    <name>A0AA38JH03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1056900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH03"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="934" mass="102738" checksum="9C6FF93F0F258AC8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH83</accession>
    <name>A0AA38JH83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1130390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH83"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="346" mass="37810" checksum="A78067DD590B6280" modified="2024-01-24" version="1">MQSIKLGGTASSISVGRVAVSSFIFSSWTPSPVSDQQAFEAIKAGVDALPDGVKMFLNSGEFYDNNWGTGNLKLLSRFFANYPAYAEKTFLSVKGGMSASGPDGSLEGLRRSVDNIQDELGSIKKLDLFEPARIDPKLPVETTMKNLVTLLKEGKFSHIGLSECNANMLRKAHSIYPVTAAEIENQKAVIATATELNISVLAYSPLGQGFLTGQIKSLADIPEDDMRAKYDRFKEENFNKNLAIVNRLKAIAMEKKVTAAQLCIAWVASLGPTMIPLPGSSKATRTLENLNAGDIQLTQEEKKAVEEVILVNQLRANGNSKKRRLRHYACDYVMAQAKVVRGLEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHV1</accession>
    <name>A0AA38JHV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_976842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHV1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="78" mass="8555" checksum="C216A4356B13B48E" modified="2024-01-24" version="1" fragment="single">VASHKSKWLLFCTGNPQTDFKTNSAFLSTQEVAPFIGQAPYFRQAKETGLLSSEEQVSVTESVRHCGAPIVFLGLHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIB9</accession>
    <name>A0AA38JIB9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_831557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIB9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="125" mass="13634" checksum="25CF5D44BD057F10" modified="2024-01-24" version="1">MANAGLGVPIKLLHESLGHVITVEVKTGQLYRGKLAEDNMNIFMRDATVTGRDGRVSQLDQVYIRGSMIRFFIVPDMLKNAPMRSGPNGMRGKGIGTARGRATIMRANARRGRGVAPTASRGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJD5</accession>
    <name>A0AA38JJD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_170460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="153" mass="16658" checksum="506A1B4A7443C24C" modified="2024-01-24" version="1">MEGTPYSDLTLKICLMLHNDADDTGGNDDATTDGIYRPPRVAPMPYVPQISAKTNHQQRAPIPSSFVSVLHTDGSMPHVESTSGLGNTPSLNHTSSRAKYLQHLTDFEEDQFGQVMMGKKEARRRVRDEDALALGSGLSGIGEESPNKICLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJQ7</accession>
    <name>A0AA38JJQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_363010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJQ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="360" mass="39131" checksum="838EC770A0806417" modified="2024-01-24" version="1">MLLQNSDRSGQDRSMNSNDSRSIVSWPLEDDHISASGVRVTMNRMHDEDVPPLEPINPPRQSSGSSSLPFRSVSGNRGIEGHDAELDDSMPFLNAISESNTSDEDWSDDNSDEIEFETFPIPLVADPRASSTTDYDGFSVPFVRLSLDSSTFDESPGHSSPQSTPGHSSRFPRAILLSRRRESEFRQEMTFDGVASNFAEATSSIVGPPESNSIDDLPHLQSVSDSEDGAHGKQHEDDGKIIDGCYLDPTHHTAEGDTDEMPPLEQIGEAEGTASKAQNMDSDSMPKLEPITTSAMAFSASPCTSPTLPDNVDHDALPSTMPPFTTDGRGRVIAASNSDEGSNETREGRSFFSRMFDVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK30</accession>
    <name>A0AA38JK30_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_329661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK30"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="901"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1063" mass="116979" checksum="6368C4FD4B1E884B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKS4</accession>
    <name>A0AA38JKS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_994803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKS4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="662" mass="74783" checksum="C2290ACE0D3B8570" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL20</accession>
    <name>A0AA38JL20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_437131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="228" mass="26031" checksum="11983993B1AF197B" modified="2024-01-24" version="1">MVHRGSDLAPSQLQLSLSQEAIPKSLARVLNAAKVREEWRKRKLEDGETEEKNGTKKKKQKLNEKTHGKTKTKSIMPGESLQHYNKRVETDMRPLVKSAVQSSKLAIRHAQRQEIASKSKRDVVEHPMPSSEPPTAQHPGRPTEFQTLSTSTPRRLNDIAQSPPEFNHLPRGVSSSSKVSKTKVEQRDGVISLAQKEMMKQEREKAIARYRELRAYRKKDHNEEEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLG7</accession>
    <name>A0AA38JLG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_295042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLG7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="136" mass="15445" checksum="4FBE4DF92949FDD3" modified="2024-01-24" version="1">MGNKGRTSPRIVCCAIPIARAAGKVLVITSRKRPDNWVLPKGGWESSDVVLENAALREALEEAGVRGTITRFVITIPTPAATYHFYELDVVSLEQDWLERNERRREWVDYAEALRRLEWKKELSQGLRLSSLAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLS9</accession>
    <name>A0AA38JLS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1061915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLS9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3734854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="286" mass="32407" checksum="32EFFF1B53356EF7" modified="2024-01-24" version="1">MAPLADFLLSVIPVSLPPYLTSFIPGKTPLSTNTEVVTALASYLVIIFGIQAYKKNRQPQKLNTLFQAHNVILSSGSLLLLLLMLEEILPIAWKNGVYFGICATEAWTPRMEFYYMVNYYFKYLELLDTVFLAYKKKPLAFLHVFHHSATALLCYSQLGGKTSISWTVITLNLTVHVLMYYYYYATAGGKRIWWKKYLTSMQIVQFIIDLFIVYFGTWQHFAFRYQTHLPHVGDCAGSESAALFGCGLLTSYLGLFINFYIQTYKKPAKGSKATNGHANGKAVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM92</accession>
    <name>A0AA38JM92_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1061841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM92"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="563" mass="63658" checksum="BEF137BC2E38444C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM95</accession>
    <name>A0AA38JM95_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1157494</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM95"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="36"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3725565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="196" mass="21876" checksum="DDB039B7A1216BCB" modified="2024-01-24" version="1">MIKIWSMKKNEELAGKKKPKTSAAQIRVQKGAASPCSTRCVFSNVVAIDLTELDLPSTMKTHFPDPADLLNFSLTITPDEGMYTGGAFNFSFAINTNYPHDPPKVKCTQTIYHPNVDLEGNVCLNILREDWKPVLNLNAVMVGLQYLFLEPNTDDPLNKEAAQEMSKNRDQFLSHVKSSMRGANIKGVQYTNVLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMC1</accession>
    <name>A0AA38JMC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 9">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1059209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMC1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3735304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="850" mass="94591" checksum="F2CA4087176A6026" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JML5</accession>
    <name>A0AA38JML5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2407 ubiquitin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_197414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JML5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="282" mass="32126" checksum="4960D1ACA3FFA377" modified="2024-01-24" version="1">MLSEKAKGKQKAADPLISEVSSSKISASPTNTRSFTVRFTEDAPDLQLSVNEQETIRDVKRSIREQRPEFKDRRLRLIHSGRLLTDGTLVSSWLKPSDERQDNLHAAWLHCSVGQKLESSEIENDESKEQISQIQPARGFDRLASLGFSEEEIAGIRRQFHNQSTSNFLDDRDFELDEEYDEHARALEEQWIDNLDNNDVSLSNSSNYNSPAMVGVIVGFFFPFIPAFINGNKPAQPIFWEDGTEQRPMESMIFSRTVQFGLVAGFLANVLFGMWRFLLDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMM2</accession>
    <name>A0AA38JMM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1060155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMM2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="330" mass="36894" checksum="1BCBD9AD40CA26C1" modified="2024-01-24" version="1">MGRPLWSTVYAAPSNETLTKTPRTWDPANPFDPDSDAFFTEGEVEIPVAEAPLMTEPDSQSYSSRGSVERLDSLEGLIATQRWELLNIMLQQRRSEALVSIRTARAAIDNQRQAEQTEPHSTPQPSAPSSNTSAQPSVASMPGLLSARPVLGLSESRPVQVEVDSDDDSTIEVPMQFAPSGNRRPRESSSVLIDRQNASNRQSDHAARRVDVNMRQAENSELALMRERRRTRLRELAQMLQSVHEGPDERLDSLSLRQRRELLYSRLASLRSGLASIPTPTTSELSPELEASETQRSMAIARSVLRAQRHREMEPRNHIHLVDLGLPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPZ1</accession>
    <name>A0AA38JPZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1203989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPZ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="187" mass="20267" checksum="FA7D7672F472FA6A" modified="2024-01-24" version="1">MRFSTVLITASFLTTVFAAPHSQINRRGDSGQVSPVSLTGPHTSNGDQKRTASPSPTDSIASFESHTSEDEQTALPKLANPVQVHIPSGTLLLKSSSIGAKATARSHEHPSYVDYPLSEYKGKADDFVLRVLLEARSPSDAGFEKMVGQLKAAGRWVDSGTAFLDDFKKKLSRPVIVMTKQKPQLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR88</accession>
    <name>A0AA38JR88_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1151295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR88"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="138" mass="15388" checksum="662B7C8C3022A9AD" modified="2024-01-24" version="1">MTSLFLYLACFYISQFPNNLITYLDLFVVGIRLTFDDSTITPAQQALAEGELSVFETYETEYALIHRPVFSWIKNDSVAIAPGRKVTLTINCFGKVGCTEGTIHTSYSYIHRNPDDDGSAKIPSSVGSEAKHVERLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRC8</accession>
    <name>A0AA38JRC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1077752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRC8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="52"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="278"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="413" mass="44430" checksum="4DA21F0D158D12C5" modified="2024-01-24" version="1">MQAKQTGLFNLPGANRTQIPPILGIAGLPPPMPVQTFGMGIGANPNLSRQSRRLYIGSITPEVNEQNLAEFFNQKMAEMNIGTSTPGPPVLAVQCNYEKNYAFVEFRSAEDATSAMAFDGIIFINGPLKIRRPKDYGGAEIPAAAPVVHVPGVVSTNVPDSINKVFVGGLPTYLSEENVMELLKSFGELKAFNLVRENGNGASKGFAFFEYVDVSVTDTAIQALNGMELGDRYLVVQRASVGAKPGTPGMIPNLPYDQFPEIPRPIMPAGETTGGDARILLMLNMVTPEDLIDDEEYGDLFEDIKEECSNFGAVEDLRIPRPVKKDKSKWTPGEGLDPQAVARIDEAAGVGRVYVKYVESISASTALKSLAGRSFAGRSIIATLLSEDSQTTPPLNIIFAPQPEAPPPLPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRN3</accession>
    <name>A0AA38JRN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fruit-body specific protein a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_148864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRN3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041249133" description="Fruit-body specific protein a" evidence="1">
        <location>
            <begin position="21"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="53609" checksum="D44E5246698F6D34" modified="2024-01-24" version="1">MVSSPGFVVFLSLAVSLVECGLVYPAFQGIPATNADPYNFNGSTTDSNVIVSTAFQVDQKSGASTDAPPNLPASNTTVTAIDGEVVNATVPASRRSVSFAVVDNQILQRGGSDYTQVFAGTGTSRQDRDAAIMGTSYLTYTLVNNATYNVADCLAFCDATSGCAFVNLYYEYNNGMLDYVYPQHSNLKCVAYGDVHSAKEKLNFGGQSLSDTPNGPLTYIQESSGWASESLSDPPTPKGYDPLPDLNGANEAPGYMGFVFLNKYDTEACAAICNNQDPNDVGGACKYFNIWRAVVDQVPTTYTCALYYIPADPSTATNYGQGNLTVTQSRGYKRMNYVSNGGFEDFTCGGLIFCYTDKTEDWLASSPKDGDYDASIFHYQPYAHSGNSVALLGSAFGRDGYTGTLTYASGLSTEPDVEYVIEFFHSSYYSGQGGELEAFVEVYWNGNLIGSIHPGYSQWKYYKFVVVAKGNDELDFRGGKAPSYDFLDDIYVMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS66</accession>
    <name>A0AA38JS66_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1163390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS66"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="359" mass="39530" checksum="4F0B2DBD0154F341" modified="2024-01-24" version="1">MWLDASPFGAFQFRCFIRCAVHFQIQQNTLHQPPKNILIVNKMRTQPVILAIDAFLEHVHSTYPGVRVFHEDRPDIPHGAEVWHPGKPEKIDLVVTLGGDGTILHASSLFSSGAVPPVLSFSLGTLGFLLPFHIDDFAKALESVFDGKATILNRMRLACTFYNQDESKKPDQADDWQVMNEVALHRGSSPHLNTIDIFVDGQHLTEAVSDGLIVSTPTGSTAYSLSAGGPIVHPSLSALVLTPICPRSLSFRPLVFPSSSSITLRIGNRSRAHAGVSMDGRTSHVLHPGESVTIQASPYPVPCINRSSIVPENEIEREELQKGEGARPGKEDDWVRDINNLLQYNATFRSKALLRHSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS69</accession>
    <name>A0AA38JS69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1058112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="173"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="323" mass="36286" checksum="202A04A92345AAC1" modified="2024-01-24" version="1">MTCSLVFTPLHSTMGALLIGVLISGALWGISAIQTYFYFSTFRHQDTLQLKLLVVFISVLDTAHQIMLSHSIYMYLVSGFGDVKYLGVVTWSMITMVLLSALIAVTIQLFMCWRIWILSKNNVYWTVPIVAIVLASFAVTTVYFEKCWSLRTWSKLESLSKISRAVNGLNFGGDIAISFAMVYLLRNFKPGIESTDALINRLMGFCLKTGLLTTICAILSLISISIWPNTFIYITFYCVLARLYTNSFLATLNAREQLRKFSRPAGSSLPSNNDIQWARDLGISSDHTETLDCSNSGTQKVETYVHSDIEMNSHGKDNVFTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSD2</accession>
    <name>A0AA38JSD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_987590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSD2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="71"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="726"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="807" mass="88394" checksum="1BA8A69E5A90D94F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSJ0</accession>
    <name>A0AA38JSJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_35216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSJ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="356" mass="39269" checksum="79F88DCCD438A50C" modified="2024-01-24" version="1">MSVQPNGGKDDIEEIPPPQKPPSPPPHTTFAARGVHPPTFSAFKPRDYRITSTQAMNHVAWNCDGKKLAAVGIDKITRVWTPEKSMEPRSATMFSGGHSDDVDYVSWNPTHPDLFCTSSQRDRRIVFWDARQSRHIQQISLKSAPVYTNYSPDGRWLIWASTQHQMYTLTFGKVGEETKEQWRLSDKDPVTGTTAIFNHSGTGLVLTHISENGFRVLDFPDFEVRDHPAAHVGGCSAVSLDPRGRYLATGGHDSIVNLFDLQDWICVRTITSCDHSINALSFSFDGEYIAIASGGNYIDICATETGIPLHRVTSLVSASTVGWHPSKHLFAYCGQTNAREGGPPAMAVVSLFGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSM7</accession>
    <name>A0AA38JSM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_990775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSM7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="120" mass="13669" checksum="64221F5F3F7E335B" modified="2024-01-24" version="1" fragment="single">MVRLDTPTKRARIVTLKDQGVSSAKIAQEFGGSKSQVNRLYQKWKQKSSFYDKTPGQGRKPKLNPQDVCHAERLLQNGKASDVIDLRNRFFPHVSHSTLRRNLHAVGLRGFQCRKVPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT65</accession>
    <name>A0AA38JT65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_758083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT65"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="274" mass="29744" checksum="FFF7AEBFD380C5B3" modified="2024-01-24" version="1">MQTIQRRAFSSTSIRRAMKIVPVPVRQDNYAYLLIDETSKKAAAVDPFDVDKVVAAAENLGVQLVAGITTHHHFDHSGGNKEFVSRFPGVPIYGGSDKIPALTNLVKDQDEFTLGDIHVKCLATPCHTQDSICYHVTHAVNKGHPGGVFTGDTLFIAGCGRFFEGVGAEMDAALSYLGTLPSSTIVYNGHEYTDGNVAFAKTIEPENKALAKLDELVKNNKSTAGLTTIGEEKEWNVFMRLSNATVRKSVEVSPDASASAVMDALRERKNNFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT71</accession>
    <name>A0AA38JT71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1212030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT71"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="325"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="777"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="854"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="944"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1110"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1110"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1182" mass="130890" checksum="4CF9897155E5F6E7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTU6</accession>
    <name>A0AA38JTU6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1057290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTU6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041240860" description="Protein OS-9 homolog" evidence="9">
        <location>
            <begin position="21"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="155"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="460" mass="51521" checksum="1AF2F4AE76BDEADF" modified="2024-01-24" version="1">MSKTLLVLALASSALVLVAARLHSLPEDPHAFPKFKVMFLNNLPILNETAQKWLNQGIPGGELEFLNQPWEHLTEQVPLSLGLQEIDDGVTGYSSPSSFESHIPYSLQHMKMGPRDSYLCLVPKPLNLSPTTSDDDPDEEITPARSWSLLQPLSGSCLYHRQGWFTYSYCHNDQIRQFRELPQAQSHIPEEDHSWESYTLGKAPATPEPGVDLTVAEQNAIEANSQLARGAGSRYLVQRWSDGTMCDKTGKGREVEVQFHCSMTMSDTILFVKETKTCSYVLVINTPRLCGEPGFRSHRDAVEQAHIRCREIVHTQTEEYHDVPETDYPQKIPRIKKALPPKVAEKLEKNIGGASGDTLLKTLEAFLGGKTNGHVVVQQLTDDGEMVIEFLEDEDVESEGGIDVELNKIMNALRAAGHDIKGERRNQQFMTGETDGEKEDEPMDSEEQVVDEQAQVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU51</accession>
    <name>A0AA38JU51_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1036782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU51"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="132"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="452" mass="49566" checksum="DEC10E2C148617A9" modified="2024-01-24" version="1">MPITRSASRATVVGPSNISAEPITPTPRIPTKRKAKENTLTPVTKEKKSRATKTALEVSSVSQAQLDEFQRNLPEPGPAPVLVPAQLTFSFEEAKKHLIDADPRFQILFDRLTCKPFESLETVHPFRALATSIIGQQISWIAARSVNHKFVRLFNPSLPEKVTDYPERAHATSYFPTPQQVANTDLVILRTAGLSGRKAEYGKRQAILIYLPSLNASSVRDLATRFADGRLSTEKLLQADDDELAEMLTEVKGIGRCLAVDMFSIFTLRRPNILPVGDLGVQRGMLRWFLGSHSPTHTFSFSPDKAGRNVQDEDELSDEEVGSLPMLNDTPASPKMTSAPQTSSVFDLSSIPPAPPATPRKEDGTETQASVASLPPPVTPSVEQTLMQVENSAGYVPPPLPAGLTASTLHSRLDGKKKIKGAILTPNEMEELTASWKPYRSLAVFYMWAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVF4</accession>
    <name>A0AA38JVF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVF4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="543" mass="60880" checksum="A5ADF5329EBFE018" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVX4</accession>
    <name>A0AA38JVX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DFJ43DRAFT_1048252</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ET3784</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVX4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041303934" description="chitin deacetylase" evidence="22">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="23">
        <location>
            <begin position="198"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAJ3736880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="472" mass="49003" checksum="50EDEB7E81945228" modified="2024-01-24" version="1">MLAGAIFALSLTGLPVYGQSSSASSSSSPASSVAVTSVAASSGASAVSSGATSSAAVSSSNTEATALTFSLTVTNPTAVPLASITANETSLPTIPLPSTATPGATNTFISGAPALPNPTSIVSSNYPTMDKVPPTDSDEVQQWIAEVAASGITIPNITQTVLGGCPANAEAAADTSRCWWSCTGCVRDTDVQECPTKLTWGLTYDDGPSFYTPNLLTYLTANELHATFFCVGSRGVQFPATLQEEFMAGHQVAVHTWSHPYLTTLTNEQIIAELGWTKKIMKDVTGVTPNMMRPPYGDIDDRVRNISIAMGLTPVMWTRMNATATFDTDDFDVHGGLASSYGVLNNWENIITHANEIDTGFIVLEHDLFEETVQLATGYILPSAMNQSFDIKPVISCLNKPMSDAYIETNDNSTNPPAASGAVTLSSGAPGSASATGAASNSNSNSGVGLKVSGTSTAFTLSGIFALVALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWJ2</accession>
    <name>A0AA38JWJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_149564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="88"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="232"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3734198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="404" mass="43778" checksum="A9CE286DB3096813" modified="2024-01-24" version="1">MFATLRRCAQVVSTTSKPTSNHFFAGTATTSKTSRRKSPLTRVSVDGLFQTYKPVTPGLRHLKRPLNPHIYAGRPVRLLTYPLRKSGGRNNTGRITVRHRGGGHRQRIRIVDWKRAEGGIWDVVRIEYDPGRSAHLALIKRRRTPETAEASAPVDGEEPQQGSGWAYILATEGMRAGDSVQSFRSGIPPDLVPGLNLTLPGAKSKSQSASSDNEDADTSSSLALGIFRALTLKSGNVLPLALIPPGTVVHNLTLTPTGPARLVRSAGTSALVVAHENADQSPSPTPTLYSQVRLASGEIRRILQSAFATIGTVSNPLWKNRSLGKAGRSRWLGWRPAVRGVAMNAKDHPHGGGRGKGKSNKHPVSIWGWGTKGTRTRKPGPKGPKNSNKLVIKERPRGVDRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JX24</accession>
    <name>A0AA38JX24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_407962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JX24"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="378" mass="41979" checksum="11363ED95F286849" modified="2024-01-24" version="1">MSGEFDDVLTNQPVVIDNGSGTIKAGFAGQDHPKCFFPSFVGRPKHVRVLAGALEGDVFIGQRAQEFRGLLKIKYPMEHGIVTDWDDMERIWSWVYAEELGTLSEEHPVLLTEAPLNPRSNRDIAAQIFFDTFNVPALYTSVQAVLSLYSSGRTTGIVLDSGDGVTHAVPVYEGFSMPNAIRRVDVAGRDVTDHLQLLLRKSGHHLHTTAEREIVRSIKEKCCYVAMNPAKEEKDTAGQHTEFSLPDGAVIQLGPERFRAPELLFNPEIIGQEYAGVHQVVVDSINRVDLDLRKSLFSNIVLSGGSTLCKGFGDRLLNEVKKLALKDVKIKIYAPPERKYSTWIGGSILAGLNAFKKMWVSAEEYQEDPDIIHKKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXP6</accession>
    <name>A0AA38JXP6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1128698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXP6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="333" mass="37124" checksum="57D7516E59591608" modified="2024-01-24" version="1">MPSSQIPLDRAYLTAIWLETLFYGINLLLFFSYLFIVRYKRRTSLSKIIVGVAIMMFLFSTVHVSLGFYRLVEGFIILRNPTEFFSDVSIPANVAKVTIHTVNSILGDSIMVWRCYNVWGQRWLPSILPILLIIASAVCGFGQAVIFAEARTTHSAFGSNLERWNGSLFSLSLATNVAVTSLIAARIWWVNRQFNILHDSSFKYRRVLILVIESGAIYSSALVIEITLYFLNNNAFYIIYDPIAQLTAIVPTMIIVLTSLGLTSADLNSEGQRTTRNRMTGLESRPQFAATGRGGNTLSSTGSTFPESEDHIGGPNADMVLKLKQKESAELVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYS5</accession>
    <name>A0AA38JYS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_986333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYS5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="89" mass="10319" checksum="B37B24AD4A1F9937" modified="2024-01-24" version="1" fragment="single">RLQQFRAEPARYQPMLVNTTIDKTNFHCTTSMLESPWNQALQFILAAHCAEIVDVCPDKLRFGLEPIDWQSVLKDKLYRMLLAITKAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K272</accession>
    <name>A0AA38K272_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1048133</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K272"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="56"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="260" mass="28923" checksum="AEE34CA258B7D5CB" modified="2024-01-24" version="1">MSLKFWKPGTAGPGSSLDRDTQTEENVVQCAPAYSSLSIQSQRERLPIYKHREKLLYCIEKYGVMIVVGQTGCGKTTQLPQYLMEAGWASEGNVIACTQPRRVAATSVAGRVATEVGSLLGDEVGYTIRFEDVSDKQRTRILYMTDGMLFRETLVDPLLSRYSVIMLDEAHERSLYTDLLLGVLKKIRRKRPSLRLIVSSATLDATSFLDYFTSATSPDDAIIVSLEGRMFPVEVAYSQQPVPDYVMAAAKTAFEINVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRA7</accession>
    <name>A0AA38MRA7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHQ1 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1141665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRA7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06463">
        <property type="entry name" value="p23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3717624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="460" mass="52713" checksum="EB94BB8B4350217E" modified="2024-01-24" version="1">MITPRFSCSQTAESVIISVYCPSVRASDVEINVDGNLFSLHINPYFLRLNFTNSLIEDDASSAQYDPSTGYLNVKLTKEIKGQEFKDLDLLAKLLAPRPTVHEPMIEVISSESTAEDPDQLVTETQNLSLHEHEILEAANNDWQLPQEVPPPEQPTLRVNAQYGFLDLYSGYFTNVAYTENEVNELGSEAETLTLLERRQRRIKHEDEKWDEEYYVADFADDEYIRELILWNHPHLSDSGTTFTEKENVTMLNLPRKEYIPTGPQTRSLYLTLTTVLFSYAYDARTTQHDPTPESAWTICSLTPSFSALDPPPYHSESNINLELSSDEISATFVPSYRRSLAFPLYRSFALAEKCREDVAHFLLRGRRTVFRCLMEMKDILDHHDVYYVYSKVWLDDLCVWTQAYASVTEMFSDETLTRLGNAVKDASITKASVGWELEQLEVAIQNQASEEREVDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRT9</accession>
    <name>A0AA38MRT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1094574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRT9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3721320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="439" mass="48579" checksum="36DDF1AA737176E9" modified="2024-01-24" version="1">MAESRMLVFDANPQKATILTREEENLARGLFANFDSAWDHPALQSRLRQARSQPGNGASTLNSMTLFGVIWSSSKRPEFQTSKVVWDAMRAELENHGVLPRLVLEFNAYVTRNGKAHRRRMENISSAWKDHEKQPRTRGTKSLVNSSSEPPPPARFFVRERPLPPSAPEIGSSTTWSSSSSFMRSSELSQEHHSSYNGQQELVDQGRLSHSSFPHPNLRPHSSLSTGSGAPSAPAQINSIFGVDETRQTQTFDQAYPSIPGVQNKHERLAHPLYPSSPFGPNSLSRETQRAATYGVTSGPSNLASTCYMSNIPQPNSFSSQAYQTDSLLPPLGYSSFSSPSFNPTTAYNYASVPPQVDHRNDYNLQSGNAYARNRYESTQNGNRQSFEYDGGLLHNSGYGDGRAVFQPNWSVDASEAFKAFCASYDTGSSSYEGNYQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTL9</accession>
    <name>A0AA38MTL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1154749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTL9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="478"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="568" mass="63420" checksum="3034E8D6B6335A97" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU33</accession>
    <name>A0AA38MU33_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotidylyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1073055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU33"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37466" checksum="737A5D10B397ACDC" modified="2024-01-24" version="1">MSAGLHSFRLLSLKGLAFRMSSTPSSSFISSSLQHLGSVDPPVEIIWTSHPLWPVPSSRALSQRKLNISVLDSSFNPPTVAHCALANTRRPRHADSSDEYDGKLLLLSVRNADKQLKPGDATYTQRIEMMIQLAEDLRDADSHGNGSNDNIAVAIIDEPTFVGKSRLLQIFLKERLRSISSSLTPEVDLTFILGFDTLERLFALKYYDASEDKMFKALRGFFSQSDGDGSCVACARRNTSSYPHTSIPSPNSASETNSLSQTISNFLASSALPSSCISIIDIGEDVWSVSSSDVREGVGKESGATEKSSGEGGFSKGGRRQWREMVPEHVRRYIIEHDLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU89</accession>
    <name>A0AA38MU89_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1008354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000103">
        <property type="protein sequence ID" value="KAJ3712987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU89"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3712987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="296" mass="34774" checksum="74CD6C3F34258366" modified="2024-01-24" version="1">MPDLASILIPALYTQILDIQFPWEGEVDMAFASQYYFRGTPDNSRQVFDALHHQALKPISKFRPSIPDFIRYLPDKSSPHYPEHTLALILLLDQGPRTLYRHLDVRWTYDYFDVASRKLVKALISSNAFPDAIEDWTALGYSFEDAMVRKFWLYGPLIHSEEIADHQFVERKIEKMRQDVENYTGEQDPFRKMKDRDAEDTELFAELIRSGPPANFADFFFWLFRVFDAHRPIIAEYGRYPYRNEAQGRITTEKEGLYLELTRNFGKPTLSGEEVETLRRQKESGQWVELSDNGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUB5</accession>
    <name>A0AA38MUB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1105518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000100">
        <property type="protein sequence ID" value="KAJ3713274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUB5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="35098" checksum="EF10E68A75BBCEA2" modified="2024-01-24" version="1">MEYMSGVELDEAWDQLQYPQKQTFARNLIDVYDQVFRLKTRRMDNLSSARRSPRWQPLSLESLRLLRSHCNHSIDNGYELGPLQDISLIDYRLVVPSPSQTMPTFTSEEYFKLVAFNGNPPTRSDFDLPTQEKCLYFVWTSEPYNFYFSCGDLHEGNILIDPQSGAINGIVDWEAAGFRPLWAEEDDQRFDDTAPEDIQLRAFIRHHLHKKNPDLFSCFVGGPELRAVLHAAVDDPSPIGETDIFLCRYHDLGYWKEGRRGAFPWDMEAWQHRRIDLDLAEMKRVAGHGDFETLWTDKWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUG5</accession>
    <name>A0AA38MUG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1161977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000128">
        <property type="protein sequence ID" value="KAJ3710905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUG5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="235" mass="26420" checksum="FC608DADED3879D9" modified="2024-01-24" version="1">MRQVYKLTNSLSNPLLQEDFTKHLHAELSNVGIDTKSPQIFSDFIAWANNPAIYLPHQVESAIKQRKLSVEGVKLSKRADSSVGVNASQGRRCCGCTMGKCNRRRIASTRNSISPRDKWIIENSEIWGMWEAHITKHKQPDPRVRCRGLHALDETQLQCNVAPDESVIVFDKDSGELIFAQLRNFCQVPAIVEWVDSVVKKNLSVQRNVRMEDAGSIVISGFTAGSRAKPSFDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV71</accession>
    <name>A0AA38MV71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_180744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV71"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="408" mass="45695" checksum="61541C2A3087A9BC" modified="2024-01-24" version="1">MNTISAPKRICIDDVPNEILADIFRWVSISSANSLSTQNGLHASEVLSQVCSLWRKLAHGSPKLWTELILKVNADTNSLNRRESLTHWFSRSRAVDIVLTLDPLRVGMQLQSVISTVYDHSNLWRRFRLSLPWAGIMSFFLIGTLCTPQLEELVVECAHSNSPAGLYPRHLAVKEGSERTVITDCGRLRKVCVALLPSFPLELLCNLLPWSGLTEVIVQKPGAHPTLIHHVFMHCKSLVRLKIWTAYWRLLDISMEPSDALRLEHLESFEVEADLRALVHILRSVQLPALKSLTLSGIANHDEELYPVQPSLAVALMELGDHAHFNLVELKTYGLLDFCKTSGLQLEDLLRFLAGNHGLTSLALKCQRREDAHGLLNSLSTGFLDEGNGRSAMLPKLTTIDVDGDWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVX1</accession>
    <name>A0AA38MVX1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_747093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVX1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3719017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="276" mass="29625" checksum="0802FE1FCD4DF782" modified="2024-01-24" version="1">MPSGSHLHGLNVIEPAHPNPNSVDLLSGPFPDLSLWTHLPFESDDGLISAVKNDSELGQMTEGDEEGQNDAGIEAAAIHDGHVNVVTGTTISSDYLPRTLPAPPSLDLVSLIPSFGINPLVLVQKSQAVQRTPSLASFLSMNVARSLPGTDIPDSTHALHSQPGEILAGTPSAKRQRSRKRSLSIEESSQDPSLDMATTLTAAEDKRQRNTAASARFRLKKKEREIALENKAKELEIRVSELERECEGLRRENGWLKGLVVGVTGAAQAQNSLTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWF1</accession>
    <name>A0AA38MWF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1006669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWF1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041449651" description="CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="530"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3716721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="89062" checksum="016E103B927C6C83" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWL6</accession>
    <name>A0AA38MWL6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1094509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWL6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3721306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="497" mass="54469" checksum="EA95C53F95E1F0C7" modified="2024-01-24" version="1">MADEKMKTVVVLGGAYAGARAVQILSKGLPEGWKIILVDRNTHINHVYVFPRLAVLPGHEHKGFVPFDKLLTPTRDRDLCLHALVRSVHSTHVVLDRSFPDRGIPTSELHFDYLIYALGSRLPAPLDLWGSHPQPGNTLKDAEMLKPYTGTKQDGVAWLKAHQEVIKNSESILVVGGGALGIQFATDIYAIHPGKDITLLHSRHRLLPRFDEKMHTEILDTLIACNIQVILGERLDTQSVFEGRTKFNGRGQRVVKTLQGREVAADLILLCTGQKPNTHFLSEMDPRCVNPHDGLAHVLRTMQLGTLPTSHSTYSSECTTPAVSSSPSASSVNLCSPEQELEDALAQIAMTNIEPNSQAAPSLQDDESELDSNETEEVETTPYPNIFVVGDAADAFGAIPAGHTAYYQGEVAARNILRLIRRSGLSQNKEENSTEEEPLEDYVPGLPAIKISLGLTKSAYQANGVVRTSDDGVPDLNAAAVWAFFGYEVEKDEDMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWQ9</accession>
    <name>A0AA38MWQ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1097474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWQ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3719139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12369" checksum="23FCE730C7F853BC" modified="2024-01-24" version="1">MLSRLAKGTRTISLVHRSVNARCISDNSFSRPSPPQLPRELQLEFEELQKQTENLPNPALSTAPPPPSTVNTDGDVNINPITGERGGPKTEPVGKWGEEGEGDWSFKGRVSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXD2</accession>
    <name>A0AA38MXD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1097135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXD2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041459857" evidence="2">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3719594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="196" mass="21301" checksum="B1358A5B8C2FFEA3" modified="2024-01-24" version="1">MKIGFSAAAPTAIGLVFVVILVSPQVHAAAIPSVMIPSATFLEDPGIQSTTTTTPSTPTLLTAFSEMSPCSNTTGVIHTITMMIAREFHFLSPRREEKNVTNPKKDSKDSKAPQKAEDAGEIAKKEKLEWERAQLKLKSPPQKVTKLKKETKTGKDENDKRILTNPFVNPVLNNALNGGTGQSFNSPFRKPGKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY27</accession>
    <name>A0AA38MY27_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1042019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY27"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="257"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="460" mass="52362" checksum="64D53B5D49B02DC9" modified="2024-01-24" version="1">MSLLDWVGVNDPWIGVNVDLVALQSIVCQVFRIPTSQCGPPIAIGLEHHARYARVYSFQLPLRAVVARLVSPVKPLFKTEGEVAAMNFVRSHTSLPVPTVFAYCSESSSPVGAEWLIMEYMSGVELGEAWDQLQYPQKQTLARNLIDVYDQLFRLKADGCGGIYYSTRQMDNLSAARRSPRWKPLSLKSLRLLRSHCNHSIDNGYELGPLQDVSLIDYRLMVPSPSQTMPTFTSEEYFKLVAFNGNPPTRSDFDLPTREKCVELFQSIHRLYPSSTLFGPSEPSNFYFSHGDLHGGNILIDPQSGAITGIIDWEAAGFRPLWAEVLGVEWFKEDDQRFMIGSNGPGEFKDDTAPEDIQLRAFFRHHLHRKNPDLFSCFVGGTELRAVLYVAVDDPRPLGETDIFLHKYHKLGYWKEGRRGAFPWDMEAWLHRRIDLDEAEMKRVAGHGDFETLWTEKWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY94</accession>
    <name>A0AA38MY94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1001803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY94"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="99"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="99"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3727174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="189" mass="21622" checksum="77592B1E099B75A0" modified="2024-01-24" version="1" fragment="single">MYPWNANYHEPPSPDELPPVPAWSTLDTYGWFRGGTNNSSSSSSSRSSRDSYDRESLPDAAAIEASRQEIINLVRRRYDIPESDPVDLTAISDTPDGSRPDATLAKILHLAIAGSPRKKLTLREIFLAIKDRFAWYKNSEDKRWQGSIRHMLSMKAEFVQVPRPFMEPGQGHYWTLNMNLTGDKRVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYB0</accession>
    <name>A0AA38MYB0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bestrophin/UPF0187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1158111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYB0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3723618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="338" mass="37555" checksum="D86B71BBC23B603F" modified="2024-01-24" version="1">MISVLHRSSYDRFWEGRKSFATVTSNVRNLSRQIWVNVALPPSDQEDTLSKKGKAPILTASQLHRVKAEALHLCLAFPFAVKHYLRGEDGLNWSDYHDVLPKNFARFDEVGYQKSKTNLTTSYNSISTKSSGRSSPDLGRGDATKRVRAVTHRTVEFRPFADDTSLPLPLIIAHEISRLLFYFRREGLLETVGPAGTNAMNALVQSMVDNMTAMERIANTPIPISYGIHLKQCVTLYLFALPLTLVNDLGWMTIPIVTVVAFTFMGIEGIADEIEMPFGHDPSDLPLDANGDETAPVCPSYGLEPFILASLTKLSILHLKRSATLDLDTGAAVRQFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYI3</accession>
    <name>A0AA38MYI3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYI3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="144" mass="16198" checksum="B244455CAC1596B8" modified="2024-01-24" version="1">MISNRYHSQYDCVSSPAIEITLTIGQRRVGDTINSGVNIRLPPAHGHFIYTGDIPERWAIPGWDIPKLGRPRLGHPKSWDIPKAGTSQVGTSQKLGRPRLGHPKSWDVPGWDIPRKLGHPKSWDVPDWDIPWDWDVPLGNSLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYZ8</accession>
    <name>A0AA38MYZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1079539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYZ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="789"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="751"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="845"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="890"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="973"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3731565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1095" mass="120628" checksum="A9D8FE87DF6BF600" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZH2</accession>
    <name>A0AA38MZH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_373612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZH2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62237" checksum="C5E0499F55CF3468" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0H2</accession>
    <name>A0AA38N0H2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1040177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0H2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="211" mass="22505" checksum="45DA414A8E0E9B5D" modified="2024-01-24" version="1">MGSTWTQALTGAGQWFHSSAHTGDLRCLLKCFSGAATIGRSNGFDDDLLGSWPFSNSSLKILLPYEFSDSLVSRKQSGAGNDFGGVNHPIMAVLSGTHFSSEKTPLIPATSAACYGYVKTATATVASKQAVLLGQTAAGQGTSKLLGQLYYSMGLWPWVDEMLGQGKPKNETVLIDGSKAIPPVPQKMLTIALLSSKPTTQGFFPKFLHKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0Q4</accession>
    <name>A0AA38N0Q4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_238233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0Q4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54376" checksum="E9BC39F165756E4C" modified="2024-01-24" version="1">MLSDLNRHLEQMKAEVALFTAKRNQLITMVDSYRNVLHPIRRTPPEVLLEIFSYGVQSVDTDYPEIYQQVNSLDTNLAPWTFGQVCKHWRSIVLGCPRLWSSLSLDLSRIEHANPAKEQEVEYKAVSLLSHYLRRSKDCPLTIAVRSTRPMHPIVSLICAHSSRWSDVLLSLPAEGFRLLSTIKGCLPNLKTLHLRNTGSLENIWNAIPVIDAFEYAPSLYMIRAYEIPKIATKLLLPWTQITHCMNNFPNGEVLYRDTLNRENIEVLSKGVKLRHATLLCSGYGPSLSITPLTHHSLAGLTIDLIRRSNPDLLIQLLDALTLPSLISLRISVSSKHRVRPNVDPIVRLLERSNCTLIKLRLKGFKTNVEENSSFRSLLYLIQNSMEILCLENFPNSLLNAFTATEDESPLLPRLRHLRVSGSCSPEMNQLLFVKMVESRVKYTKFKALVTSSQFVLTNPEARNRLDLLDNKCHPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1Z9</accession>
    <name>A0AA38N1Z9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 12">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1062776</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 12"/>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1Z9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3734446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="364" mass="40444" checksum="3C3BE9F9216115AC" modified="2024-01-24" version="1">MVEFPPLRNDLLLRAARGEKTERAPVWIMRQAGRYLPEFRALRADHEFFEICRTPELATEITLQPIRRYSGLIDASIIFSDILVIPQAMGMEVLMNPGPSFPDPLNVPADVSKLRQNVDVEKELGYVFKAITQTRIGLKGEVPLIGFCGAPWTLFAYMIEGGGSKTFTKAKTWLFKYPEESKALLLQIADVCVDFLVGQVKAGAQLLQVFDSWAGELSPLDFSLFSLPTLKHISKGVREKLSNQSIPEIPMTLFAKGANYALGELAKDSGYDVLGLDWCIEPSVARKIVDGKVALQGNMDPNVLYGGREAIESAVKRMCEEFKDGSGEVGAWIANLGHGITPGVDPEDVRWFFECIHKYSARKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N210</accession>
    <name>A0AA38N210_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1062990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="89"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="5">
        <location>
            <begin position="760"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="6">
        <location>
            <begin position="1066"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1306" mass="146781" checksum="3F27B9F0B1320926" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2Q0</accession>
    <name>A0AA38N2Q0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1130127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2Q0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="495" mass="53867" checksum="2F4540F1A7D30C3E" modified="2024-01-24" version="1">MLRLVLQCTAIVCTSLLAGGIFVFPLLAPALMEHLKLTQPQLSSIALAGMAGQYPFSSVVGKLIDHYGPRVCSFLAAVIFSAAFALSAMEISLSPEHSERPNTAVAERLVVYFAMAGLGTVLSYFSFVFSATKTFTNYFTIASGITMSLFGLSPLFLSYIAGKFFTDSSTGSLDVAHFLQFLALSTGIAHLVGAYALSLPPKNTNTSQPLSVSNSGTADTPNERSHLLDREDSSDCTADPRDGSALRLLQDCHFWLLALYMVMILGVVGLFPYFIYSVSWLTFQMQCEMIMSNVGTIVLSLPSSTVARALVFEGQQAASLQVKILSISNTTSRILVGPLADFISPVFEYQHLEGYMTIRKHRISRMVFLSGAAFLLAATCAWMVFGVQTQHDVWLLSVGTGITYGAVFTVLPGVTCSIWGIRNLARNFGIITYSPFIGTTLYSYVYALIVTRHSAEGVACQGRICWESTFYFCLGTSLAALAITPILWRNWTGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2X0</accession>
    <name>A0AA38N2X0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1151101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2X0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="619" mass="70217" checksum="FA104FB72C57A04E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2Y1</accession>
    <name>A0AA38N2Y1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_991567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2Y1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041268396" evidence="3">
        <location>
            <begin position="22"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="81"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="612" mass="66351" checksum="4983AE2EE2565D91" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3E5</accession>
    <name>A0AA38N3E5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_962482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3E5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="72" mass="8185" checksum="6227FDBDDF154322" modified="2024-01-24" version="1" fragment="single">SRHCYIDPIMADHCELDIATQTHWAKLIFLNQASLEQPPNNLTFDHKHTKQARVSQNSLSNAPPIHFHLSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3T7</accession>
    <name>A0AA38N3T7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1130276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3T7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="289" mass="31632" checksum="42FE5F9C0E002A70" modified="2024-01-24" version="1">MATSTQSKPVTGVPIEISSVSEWNSILRHAYANNQTVIADFHAEWCQPCKVIAPVYANLASNQPFTYFLRVDVDGNRTRPIAAKYSISAMPTFVVIKRPPGEEVTENETGKGVVVDRLQGADAPGLARITNTHASRAYTPPSTLQTREAEKSKDIGNDLFKKRQYAAAVDAYSKAIELSPNSGVLYANRALAYYKWIQSNRDGADSPEARNALRVKQMEDGLKVTKLEERWGKGWVRLAEAFLEAGCEESMAVDQGLEGRRHNLEAAEEALTSAVGLSEGKAKAGKFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N424</accession>
    <name>A0AA38N424_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1221956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N424"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="268" mass="29981" checksum="B526AAFF557E55D2" modified="2024-01-24" version="1">MSSTSTSTYYHTPMPSHHHFNLRMILRSANERYRTVAETFRRNRVQLSHHARRRAQERGLEIDTGRARRCPQKLVSVLPLHVIDTSVSPALDRAAEEEVISVIAGPPVPVVERPVGVVPRITVPFRVASRPFVGCDASVSRTNSEPYEIFAPVALRGQANPWRGPTSRFSITPNDEVFQVNKPVIPDLPQDMTEGEDDSPSPSSSSESSSSGPSTPEDYSSLLIRFKRKSLEVEDEIASAAEKRPKYARKEWNQCSSQSIERTCRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N438</accession>
    <name>A0AA38N438_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_43270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N438"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="24"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="555" mass="59465" checksum="4B6F09DE55FFFEFB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5R1</accession>
    <name>A0AA38N5R1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_987358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5R1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF5">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="196"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="449"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="844"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="976"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="727"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="985"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1054" mass="114518" checksum="66FCE70A09CF2FAE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1P1</accession>
    <name>A0AA38J1P1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000134">
        <property type="protein sequence ID" value="KAJ3710636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1P1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="85" mass="9438" checksum="05CBE3A890820A9E" modified="2024-01-24" version="1">MSQPDVDDNSSDNHGVQYLEHPAGIVGVTGEPKKDETHRQQRQQLSQRRPGQYIVFLTTSFAHKKLSQSKAEAPVNLVLGDDVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1W9</accession>
    <name>A0AA38J1W9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="7">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1161351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000105">
        <property type="protein sequence ID" value="KAJ3712775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1W9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="10">
        <location>
            <begin position="173"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="9">
        <location>
            <begin position="449"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3712775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="625" mass="71440" checksum="36189CE92B841163" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3A9</accession>
    <name>A0AA38J3A9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_808570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3A9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="126" mass="14104" checksum="2F0479875CAF9073" modified="2024-01-24" version="1">MQILSIYLGFILGFSLPCRLHLLVASRDSKTSARGLAMTSHPRNRHKLASQRNRSGTLTVPAEVSHRLANYFHEHESDILLDDPVNQIGYPPGTEWPAGRSNRAAVDFAWARSLDSPFTRVHLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J515</accession>
    <name>A0AA38J515_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">rRNA-processing arch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1091916</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J515"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="147"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="381"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3723458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1065" mass="120179" checksum="0A20A7C6AB2829D8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5A9</accession>
    <name>A0AA38J5A9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DFJ43DRAFT_1003079</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5A9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="270"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3724268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="322" mass="36546" checksum="24440BC5E94C0192" modified="2024-01-24" version="1">MSGIPVFPVAQQAQIIRAHQRDLYHVSLLREQAENTARAWLGTRRLTRWDKELELLVKLLYYGLTTGRATQTLGEEYTDIWQYSTTIPPSRLTRAALVLLPSLPAYILSRFVNMANISARNLRLATILRTLPFLLESLTEINLAVFYIRGIYYDISKRLLGVRHISSLPENPHIRPPSYSLLGVLIAVRLIYRLISFLQSRTSNSALEEKGKRTARGSANRETYLDDRPVSQMLNIIDPESEPAKPAEQDVRTMLDVASLSPAVRASRTCTLCLEERTDSCSTECGHLFCWSCIVGWGREKAECPLCRQSLNPTRLLPIYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5K1</accession>
    <name>A0AA38J5K1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_725180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5K1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3720288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="638" mass="70418" checksum="37D15652C3E43D8D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5P2</accession>
    <name>A0AA38J5P2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1092154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5P2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3723522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="261" mass="28805" checksum="1989C11A1F509DD2" modified="2024-01-24" version="1">MSELLNVGNCCFLCSQIDFLPTLCPFCQNQFCKNHIQHEAHSCSAANRTDPVELFTKLQRCTLDGCKNPSLNASRSSSIPTCKACQGSFCVEHREPASHRCSPIQGAPESTRNETARALLAKNFTSNPSSKLPVKRRIPAKPIDPAKLAQLRKLELMKLRQLASPLDSKLQKTTIPVDQRRFFKASMDSKPTRELWVEKNVITGKAFDLLAAQFGIPNAETDKYQLSQVSGEAEQSGALLYDQPLADQVEDGGELVLSIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9A8</accession>
    <name>A0AA38J9A8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_740815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9A8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3719581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="74" mass="8821" checksum="F346B2110025D5AE" modified="2024-01-24" version="1">MMVIWALISISSTILQRTFPMGGSRNLRLVRFIAFWYAPKIVKMQDDEKIRMKLINLQLFPSFFRYYTSAGQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9F2</accession>
    <name>A0AA38J9F2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1075618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9F2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="409"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="867" mass="95263" checksum="121494B203D42F95" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9T9</accession>
    <name>A0AA38J9T9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1007855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9T9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="191" mass="22103" checksum="C46BD805FD21531B" modified="2024-01-24" version="1">MSSPTQSEASNPIQAFFERYGSFDYDPAGETMPQFWKLCDLYDWDRDSDEREEALTEIRDAIAQQFNAFYGSDAESLNGWHSLYRALQIADIPDTVQGCKDMIETIHVNICDLVDHKEDVPQKHSTEDELADYSRRTGKIYPRENAYAGGLLRFLLRQITGEYHGKRRDRGQQRGGRKGRQGSKRHRRGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9Z0</accession>
    <name>A0AA38J9Z0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1044075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000103">
        <property type="protein sequence ID" value="KAJ3712991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9Z0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041429596" description="Oxidase ustYa" evidence="4">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3712991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23150" checksum="E2A70579D8F09898" modified="2024-01-24" version="1">MAQFATHLHLFVFSLTLLLAALNFQLFNSMIQEVLNIDHYWSTSNAELPIRLRPAALEIVPTELYHILNDTQWQTTFSPQPGYTFGFVRLGTEATPFEPAIFHQMHCLNFLRQSLVSDDWADVSEHGPRLWHVNHCLNMIRQAILCNSDTTLEPSYIYGTHKGRNQSAASGMDVWHVCRDWNQVNEFVKENYKQTRNISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBL2</accession>
    <name>A0AA38JBL2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1159042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBL2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="272" mass="30101" checksum="F8A16CAF89E1926A" modified="2024-01-24" version="1">MYEWILGMGYRTLCKNSRLFLMPCELYVGLPLSSLIPNRFQSSTVFIAFSTTTYALYSPPIRLWIKYRLTWAWSQWCEFGLTEIYGWCFEEEEGLVYENILVFHPGAPSNIRASFEHSGTFYTHVSLLHPHRGYKHPPASAHGQQSDRSHLLALALRAIYPSPQAEEAICATVQKVDQLDPLRGSRHDGDDPGPSTQSKTGAASAPLPVFNARLLARLSKELEEGMSIFLHPISVPSIWSADCLATGGELATDPAASSAAQGPTESQQIASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBP8</accession>
    <name>A0AA38JBP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1066521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBP8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="854" mass="94727" checksum="4A730D44CAC7E5A8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC32</accession>
    <name>A0AA38JC32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS Git1p-related glycerophosphoinositol and glycerophosphocholine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1075724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC32"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="16"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="485" mass="52432" checksum="C2732C360B174913" modified="2024-01-24" version="1">MTDQPTLRNRLSGVSLIFACGTALFSDGYANGVISEVNTLLKRIYGDEVTANNYSTIVSSVAFAGTVVGMLIFGYLSDKLGRKFGMMTATGIVAFFSLLSAASEGAHHSVRGTLAMLSACRFLLGIGVGAEYPCGSVSASEQTEQKSISKNAQHRWFALATNSMIDTGFVISAFVPLVLYWIFGPNHLRAVWRMSVGLGFIPAMLVFIWRLNMDEPESYKKSSMKNVKIPYMLVLRRYWPSLVAISVTWFIYDFITYFGIYSSTVVDNITGGSDAIPVIFGWNIIINLFYIPGTIGGAFVVDYIGPKYCMITGLMSQAIIGFIMSGLYEQLTSHVAAFAVVYGIFLSFGEFGPGNCLGLLASKTSPTAVRGQFYGIAAAIGKIGAFVGTWAFPPMIDAFGGASSVRGNTGPFWVGSGLAVLSAIITFFFIRPLTHDGMAEEDEKFRQYLEVHGFDTSAMGLGETGSVTAVDETTIDEKVDQKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCD7</accession>
    <name>A0AA38JCD7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial chaperone BCS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1131967</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCD7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="43"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="256"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3732309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="459" mass="51699" checksum="43B4FC0262C2A834" modified="2024-01-24" version="1">MVAENPIFEGLNNAAASPSLQNSPKTWLEGLDNPYFQAGFGLMGVTVVFGGLRKFTTVADVFLRRRLLVQVEINNKDRAYPWLLSWMARQNQINQSLKRGSGSLISKSHRLSVETTVEQHQNGSSSVSFNLVAGTGMHWLKYRGAWMQVVRERDTRSMQMMSGNPWETVTLTTLSRDRDIFPELLAEARDLAMRGQEGKLVIQTPWGTEWRPFGLPKRKRPLHSVVLDNGIAATIENDLQSFLNRRQWYVDRGIPYRRGYLLHGPPGSGKSSYIQALAGSLDYNLCLLNLSERGLGDDKLTYLLSTVPERSFVLIEDVDAAFNKRVQTSEDGYQSSITFSGFLNALDGVASGEERIVFLTTNHIERLDPALIRPGRVDFTQYVGDATPNQARTLFERFYGTEPLETIDIGQHLHDLVKEEMKYGRYVSMAALQGLFIRNDDAQGALVACQQIFHEIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCE7</accession>
    <name>A0AA38JCE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD dependent oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1074960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCE7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51008" checksum="3F0E9260A8210147" modified="2024-01-24" version="1">MSTFATTGMVDGQLVNSPLDILIVGAGFGGVYMLYHLRKLGYSVRVFEAASDLGGVWRNNFYPGARVDSEVPVYDLSLEELWRDWTWTERYPGYEELRRYFDYIDQKLDVKKDVSFNKRVVTAHFKVGVDRWRVIAEDGTEVYPRFLVICIGFAAKAYTPHLKGIERFQGVSHHTAMWPEKGLDLKGKRVGVIGTGASGVQVIQEIAKDVEQLSIFQRTPNFAMPMQQTKLDKSGQEKMKALYPAIFERRRETFFGYSYEPLTKNFLDATASERLLHFEEQWTSGGFRYLIRNYADIGLNQAANDEVYEFWKNKVRERLHDPALQEKLAPSIPPHPFGAKRPSLEQNYYEVYNRLNVDLIDLGQCPITEVTPQGILTADGVEHKLDVIIFATGFDSVTGGITQIDICGLGGKSIKDKWAEGVATNLGLTTASFPNMFFTYGPQAPTGERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDJ1</accession>
    <name>A0AA38JDJ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDJ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="230" mass="25959" checksum="8AAAE870F684CDE3" modified="2024-01-24" version="1">MSSPYPSFRQRRLYPAPSSPGPMRSPRCFRGEPPCSTVPRSALHSTSSREPEKKTTGYFIHTYIDDDDETGVLVPAKKVHFDVIEKPETSGPSNRPLSTPASPGRSDIDDSDPEVDDKIPKPPGPVGRPGRNGYNLRVALQWQDERHEKVKAFINKLVDSKLDCTISFSKQVKEKLDVVRQQAATKFPILAEYRGQWATDDFIRCRLKSRRVALQKAELERQVGETRIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDN8</accession>
    <name>A0AA38JDN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1151320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDN8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="224"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="577"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="95744" checksum="461BF5F62B7AA3B1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDX5</accession>
    <name>A0AA38JDX5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1223508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDX5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="107" mass="11926" checksum="0738D6DDA404589E" modified="2024-01-24" version="1" fragment="single">MVSTSVQFNASDADVVIHSSDNVKFRLHKKNLECTTGAFPSADTPVDPDEIVRLTESAATLEILFQFIYPRRFPSLKDLDFDSLILLAEAAEKYEVVGLIYACEVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE23</accession>
    <name>A0AA38JE23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1059236</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endosome membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE23"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="13">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="275"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="464"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="680"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="622"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="680"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="750"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3735307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="821" mass="90163" checksum="E1BE4E7040AD2A5E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE48</accession>
    <name>A0AA38JE48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_861072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE48"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36335" checksum="A2DB7ECE2FB02868" modified="2024-01-24" version="1">MRNPFLIIRFIFLSLLLFLNLLDLIFASWNASAAINANLHPSLFLIFNSVTSIFFLGLGLVELFAPNFAGTSVAFESGWSAVLSLSHIGAAIGVTIAASVFIKQTIDTSVNASSFLLVPTTWLTSLTMLGYSFILLVSAMTHVPFEEEIWTKPVCQVKWFGYTNARLRSSDVSLPRELPGLENDSWTRYLDDIESSGVRKARHPVPNTEKAPWAPTNVRRGRDSPFRGPTKRENSDSSDTSSDCSFSVGVRDSAPLPPLPLNVQVKGGKPVGESRFIERFRESQTLSRPAGPTVDFPREVDDHDKPIPLTRLSQWIRADAVKAFALRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE63</accession>
    <name>A0AA38JE63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_864110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE63"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="269" mass="30241" checksum="DCFF17E0C7B6B72C" modified="2024-01-24" version="1">MSTTNRVLAGPSGECCFTGFRHEGTPVGNTITIAEVPTYFVEGSAKNGSDAKRRILIFFADVYGPFYQNNMLVQDFLAQNGFTVLGIDYFMGDPVHSHDGEEGFDRAKWMEKSHKIAHEVLPKWWKAVNVKYGNEANYCVVGYCFGAKYTMELSNDDAIVAAALAHPAFLNEDHFRKIKKPLMLSCAETDHTFPLQSRRIAEDILVERKAQYFFQVFSGVEHGFASRSDPSSPDGRWGKEQSAHGIALWFHRFLDESFQNGKGQFSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE97</accession>
    <name>A0AA38JE97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1167140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000112">
        <property type="protein sequence ID" value="KAJ3712083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="37"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="226"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="293"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3712083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="562" mass="61682" checksum="F668479F1EE79C72" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFE6</accession>
    <name>A0AA38JFE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1038293</name>
        <name evidence="2" type="ORF">DFJ43DRAFT_1040789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="274" mass="30962" checksum="5036CA3FD4E2C4FA" modified="2024-01-24" version="1">MTPPVSRPPSFSSLLRGSSLSLSRTPSFSSLPSQSDPKSSNSALLAAQERRKNEQLECDNALLQIRYASALAELSVLKEKITEVQEQRDAAETHAVLIGQQYSVYKHRYNEKAQKKDSSRRVTTSSRILTSREGRLEIEEETAKRAEKLRTETERQKQKSDAQRMDIVRRAEQDRLGSEFSGNMKAMIKSKLIDIAFALKVPHEDATVDTLRIRLNAHFDANPALKKEPRYIGLFERTRKRKDPPQEDTTRLPPPPPAFQSHPLAMPGTSSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFN5</accession>
    <name>A0AA38JFN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1151724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFN5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041239832" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="388" mass="42560" checksum="B851FC1C75DB9F32" modified="2024-01-24" version="1">MWNTQAIALTLVLTSTFASAAIFPKDTVVKMLDPKGFRKVMKANETTMVAFVAPWCGHCQRMAPEYSKAALGLYPLIPTYAVDCDADANKRLCHDQGVQGFPTIKLYPRGKQLNPLTYDSGDRSSSSFFYWASRRVPNHIKKIGQLDDIQRWVEESAERGLPRALLLTKEKIIPLLWTVLGNKFAGKIELASHRDRKGKSSVAMGYEAGEQKSSKVLIYAPGSTTPVRYEGINKLDSLSKFFESVIDGTADLKAVNEEAASEEFVPDEAELEIERKQEAQRIALAHGGFANFIDFEDALKKGHNPHGSQGYPGMMGDMPKKMKETESDSKVAESMVETGDAKEQATFAASSAEVPAPTAAHTPEPSEVPTEETKASEPEPASAPKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFN6</accession>
    <name>A0AA38JFN6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1096437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFN6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="308" mass="33873" checksum="B26E2EDE3C9E198E" modified="2024-01-24" version="1">MSVHFPSSSDSISRARFTNARRVPNDKASNRHMACVGEGFADKVTFCSSVGNTYTTVTFTPPARRVRHSDAADSFPSRARFNRLAENEEVKAAAGVETKMKKGYSQMFLKKVRSLLNRNSVNNPKGSSQPPHAVSSVSGQESRPPLTNSQSVPATTASLHRFPKRTVRPMASVATIACTRTQGSSNILNSDNPSVRRAREPRSRVVRRSRSFDDAECSSLAACIALDEAVRDLIARETAENQQRDNEVSSTNRSSREDSDIATDDEETLQNHGSPDGGVWILEDLMDLLKAENDQIAALLAEDEDRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFV3</accession>
    <name>A0AA38JFV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1130260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="390"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="442" mass="48744" checksum="C1C71B61C5C2229F" modified="2024-01-24" version="1">MGMDKGKRWHRSPNLRTSEAGSSRISPSPEAPVVKRCKHKAETRNCPICNEPIPLRLLGKHAELESSRVDEIIGHIGSEEPFLDLSYESYSNPTFAVASTSDLATSHGRRSAVRARRSILEKTAPVRAQSTVISKAIQSIKRNRKNRHGKLRDMTREDDEGHLASRLRYTSGRGDVVCPVCLDTVQGDEDVQDAHIEACVANESVRLEEERLKREEQEIVEAEEVDIGDDAAAGHFGDVRGTGFHTRNHNERDVEDEIDIDGDDAEFFGSAQFHEADILDIDAPPTTAARTQPTSGRLQAGGVDDSCPEQETEEDQPAKVLRDLIADSKARQSSATQEVAIIPEIDKADVAILMARSRGNQAALVTALENKIQLLEGPLAQSPSSSSPLCRICIEPYSEPTVSTGCWHTCCRECWLRCLGSTKLCPICKRITAAMDLRRVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFW2</accession>
    <name>A0AA38JFW2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1132778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFW2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="3">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="840"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3730977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="909" mass="103881" checksum="2C94F79C1FAF35B1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGM1</accession>
    <name>A0AA38JGM1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1155382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGM1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="146" mass="15979" checksum="788427E7B136D9AF" modified="2024-01-24" version="1">MTTDDFCSRSWQSVHTLFTSTLSLFLAYASSLRLRLLFLLSALSLSEVHWRALLVGSPFPHILSSSHVATVTDTFTLQVLAILARLVYPLDFAMFPVSVFIGRLLVAMDALVVGLSPWSWLIDSCTSSTLSTLSCIPVPTIPVGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH26</accession>
    <name>A0AA38JH26_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PQ loop repeat-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1004099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH26"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3722175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="278" mass="30925" checksum="9C1D59482E1E0716" modified="2024-01-24" version="1">MPVNSVAENVFGTTGTVCWTIQLVPQLWKSYREKDTTGLSDWMILAWGVAGAFLGTYSIVKNLNIPLILQPQLFSVLTMASWAQCQYYGRKRPLRVTLLLFFCGCVILGGFEVGTIYALRPSFNRGDRSGTEGTEFFGIMSTVLIAISFIPQYYEIYKRREVIGISIWFMTVDLLGKCCVFSDLSLVFKSGVFDIVPAVTYSLVVVMDGAVILAAWILNPRARRLRLQRQEPEVSESSINRSTTGMVQTERVPAPIDSESPSETAATSPRSSCLLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH52</accession>
    <name>A0AA38JH52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1138641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH52"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="150" mass="16654" checksum="E41AB9B24A0412AF" modified="2024-01-24" version="1">MLFPKPPRRERNTQAESIIGTTLANFTKSDMDQSILFAGLMAHARETQRKNLWKLKKQTTLPKATRGAERYAMSESGSQSTTMGLNAKISKWRLTATKNTSARKDNEDMDTASCDVETNAQEDGPSGEVLSYRLVQSTDAAYLVPVPYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH95</accession>
    <name>A0AA38JH95_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1080659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH95"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041264148" evidence="1">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="241" mass="27048" checksum="62D3D2346C60AE3A" modified="2024-01-24" version="1">MILCSFPSLLFLLVALAHSIASPVNLASRYNANSLDLDNSNATHDLRRRINFDDPKLIMGYLAVPEATAKEYNAHGFTAIPLRSSYKPLGDDGTYIDAAPIPDHLLPGSFWKCGVFIDTIEMVQTLRGYVDDKTSPAYNKPGYLKFFIADLRKLWARSRKHFLSGPPLLVARAKKGWSQLVMLIPSEYLIKSPSNPRQPSGENHLKLSIKCTPKGTALDVDLPSPKWEDWGFEYWPKDLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHC0</accession>
    <name>A0AA38JHC0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_805198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHC0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="215" mass="22671" checksum="187C0751D8B53CE2" modified="2024-01-24" version="1">MDNLNRQNSSSPQGKRSLSDQISSIGARINRALSRGRSTERPARDFDNESLASSNTTVVSVEGAIGERSVSRGRQGLHHSSGRGGIGNIVPSSVPEDVAVEHSASPIRGRDIARPLGGPGGTSFSSSGRGGIGNIRAPSQEQQFDADAITLVPSRSSDNSNVRSPSQTSPSRNVLSTGRGGIGNIKRNPGGDSTTQRRQLRRMSKMGEIKKTLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHI5</accession>
    <name>A0AA38JHI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_991681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHI5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="85" mass="9526" checksum="4D86B8295DBD23B9" modified="2024-01-24" version="1" fragment="single">MLHCVELKEDQHRAYDIIAWHLNQTLAGRKPPALRMILYGEGGTGKSRVIQTITQFFEQKHAKHCILKGAYTGVAASLIDGKTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHN8</accession>
    <name>A0AA38JHN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Up-regulated during septation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1159606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHN8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="140"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="547"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="860"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3718013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="950" mass="104676" checksum="25F24040699AFFE5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHQ3</accession>
    <name>A0AA38JHQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_996098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041373874" evidence="4">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="387" mass="45366" checksum="0ED46D6468E28C95" modified="2024-01-24" version="1">MMTPMRYVVLVLAIVISIHYILSLTHDGYGQATSISNLKSQWSAGRPPYKTPVPDEYYVSENVTAPSGRRANAAIVMLARNSDLNGIVVSMKQMEDRFNKKFRYPYVFLNEEAFTDNFKNRVTELTDAQVEFGLIPREHWYQPDSIDEAKASAARTDMVKNNVIYGGKLDVSCLWQIYRNMCRFNSGFFYRHPLLDKYRYYWRVEPDIKFFCDLDYDPFLIMQDQNKVYGFTVSLYEYEATIPTLWQAVKEFIHENPDLVSPDNAMAFLSDDGGESYNRCHFWSNFEIGDLDLWRGESYTKFFEHLDKKGGFYYERWGDAPVHSIGAALFAKKEQIHFFNDIGYRHEPFQHCPQGEAHSKGKCWCDPAQNFDYEWYSCLARYDKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHS0</accession>
    <name>A0AA38JHS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Spb1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1049330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHS0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="245"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="664"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="620"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="849"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3737122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="888" mass="100256" checksum="F83F028C95543411" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIF6</accession>
    <name>A0AA38JIF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1117952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIF6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="117"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="559" mass="61011" checksum="E01F8BC11564EF6F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIP1</accession>
    <name>A0AA38JIP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Le.MFB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1067843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="147"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="807"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="945"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1189"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1383"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1431"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1879"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="973"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1015"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1148"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1229"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1262"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1468"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1531"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1569"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1622"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1646"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1686"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1723"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1755"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1879"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1893"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1959"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2028"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2058"/>
            <end position="2071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2169" mass="234496" checksum="D7627E9B891566DB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJG7</accession>
    <name>A0AA38JJG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FRG1-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_320566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJG7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="284" mass="32041" checksum="66E7BE9FA08625D9" modified="2024-01-24" version="1">MGDDKIRSTKLKFKGDKAKKKRRREDGEEGSSSTKRRKEDDVDPETWVLPENPNEIRGPTFIIHPSDPSPISLNFNSTTNRVVLHLIDKEKPEDDTEPQSLLERTPTDVSQVWVTTRVAGSPTINIRSGSGEGKFLSADQLGIVSCDRDARGPQEEWTPVIMPDGMVALMNLYEKYLSVDEVAGGSLQLRADSDEVGFKERFWLKIQSKYKKEANEEEKKKKEGMTGPPKIDETATNHLYQAWGAGRSVVSSDDKKKLKHARKEGRLAEALLDRRAKLKSDRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKQ9</accession>
    <name>A0AA38JKQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_131936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKQ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="688" mass="75706" checksum="CA2E7B7D30AD3502" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKS5</accession>
    <name>A0AA38JKS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1133654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKS5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="34"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3723549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="256" mass="28702" checksum="1A81F04EF19F1F9C" modified="2024-01-24" version="1">MSATFNLPQVPSTPPSVSYIDFASTPLAKWYSGSYALVVDNLFSPQECEDLIALAELATRKIQGGPLPTDQILNTRYRHNDRILRFDHDAAKKIYERVLPIVENDIGTIKEGSKWGTIVGGGNGDQVRGTWNLVGLNERLSFLRYGPGHFFKKHLDGRLDLPDGRKSRVTIQIYLNGSDTATLEGGATRFCDPGYWYPKDLGANVDFQPKFLDVVPKTGSALIFQQRGLYHSGETVQEGLKYTMRTDFMFEQIFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL23</accession>
    <name>A0AA38JL23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_999388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL23"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49874" checksum="30EC2065E050A48B" modified="2024-01-24" version="1">MAKDLPGFYFDIERNRYFPLSSRPSPVTAEGSSTQRNAPSHKRPCVETEPWPTTTPSAIVHRTRNLLSSQALNQRILNTHDVHCSRLASTSRFDFSQTASFGNITEFCSATSEDGLTRRYIGDDKGWFYTCTVAQMYMWPPEINLHSLSQVSSIKISGHNCVTTCFGPVTKVAVQDLHASGRTTLITFNQVHDVRASHFQDSSLILGAKGKAVHIPNIDVSGSVQYLNNRQNSDIFAVDRDKNLVYTGARNGSITRHDLRVPSEKNGQWLFQSRFSAGKDNTVPSSVLYLKLVQDSQLLVSQMNGELCTYDTRFPMKNTPSRIFRGHRNSVTQKLGICLDPGNDFIFAAGEDHRIRGWSLRTGKALHDDSSASASASATSISVSATTISMASSSSCSSWNQFRSPFKTSFPTPVPTMQVTEERDGSLCLWAGSQQTLYRYFLGQYSKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM64</accession>
    <name>A0AA38JM64_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM64"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="954" mass="102711" checksum="D5644ADC41303575" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMG0</accession>
    <name>A0AA38JMG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_277997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMG0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48718" checksum="AD3F4DB86AE41B4A" modified="2024-01-24" version="1">MPLTWSTIKINFRSSTARAARLSRHSAEIMCVCIQRTRDCPLTIAFTCASDVGATARDDWLRCLDSLVAVSERWKSIDFFIPITVLSRLLPAKGRLKSLEVLNLSLEPQNARSLPRAMDIFEDAPKLTRVTMSSHLSLDTFRLPWKQIIEYRTKLMEVWNCVEVLHHAPHLRALHAKLERARGNISGDTASPYSNHLDHKTFSYESLTSLSINGLMRPGYEHELFLRLLQVSSDSDKANVTQILFPSLTNFRLATSSGSLINFAALPLAGSCFGSLLTKVTIRSVFDALADYSGAKDFLLGLPMVRQLTFGVCFHHNRDVVHILYEILSLPSSSDSGWPLVVLPKLEVLVLDIDYDNKDLLMPSWVIDPLKKMIRSRRTKDFVRRCVPLQKFHLYLASWETPRESFAKGLQDLTEEGFEIRVLRGLFAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMW7</accession>
    <name>A0AA38JMW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L18e/L15P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1156839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMW7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3728038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="147" mass="16623" checksum="13D4570E452A0E46" modified="2024-01-24" version="1">MPTRFSNTRKHRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNFDKYHPGYFGKVGMRYFHLTRNQYWRPIINVDKLWSLVPEEEKKDLTEDSEVVPVIDTLKHGYGKVLGNGELPKLPFIVKARFVSSIAERKIKEAGGVVTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNR6</accession>
    <name>A0AA38JNR6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division control protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1066515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNR6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="576"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3733730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="762" mass="86138" checksum="25FE776474C7B544" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPG8</accession>
    <name>A0AA38JPG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1069949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPG8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF306">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="543" mass="60314" checksum="FFF34AAE88049ECD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ63</accession>
    <name>A0AA38JQ63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1130216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ63"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="345"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="449"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="345"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="449"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="566" mass="63282" checksum="5B0182A21A25CA93" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQF0</accession>
    <name>A0AA38JQF0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1058631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQF0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="83" mass="9353" checksum="904F042FF124E9D0" modified="2024-01-24" version="1">MVRIHSLCGVSIPCNLYIVYLSVSTRMTLFSSPLTLTTYGWIGEPCWCSLAVVVAKTCMNIGRKYSDEECYVLSYCSRIQVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQN8</accession>
    <name>A0AA38JQN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_994098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQN8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041287412" evidence="5">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="299" mass="31651" checksum="EDF14BDE3184FACF" modified="2024-01-24" version="1">MHPLSWLFAVLSALGLTSGTPFDLHPRAVTRISASELAGFAPYTQFARAAYCPTDVLKDWKCGEACEANSDFEVSLVGGDGDDIQICKYSPSLGAVIVAHQASAILFSDLTDADILLATPSTALFPGISSSVEVHSGFLNKHALTANVILAKVKSIMNSKVTNNIVAIGHSLGGALAEIDTIFFRFNIPSASISAMTYGTPRVGNHAWAALVDASDVNFKRIDNEIDPIPIVPGRFLGFEHPIGEIHILSAGNAVSCPGDDDASDADCQIESVPTIFEGNILDHLGPYEGIYIGTIFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQQ8</accession>
    <name>A0AA38JQQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_994072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQQ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3733941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="317" mass="34613" checksum="37815A2CF2CB57F6" modified="2024-01-24" version="1">MSRPQDDRNQEATVYLGNLDERCTDALIWELMLQAGPVVNVHLPKDRISMAHQGYGFCEFLTEEDAEYACKIMNQIKLWGKPIRVNKASSDKKQLDVGANLFIGNLDENVDERLLYDTFSAFGMLATTAKVARDPGMGTSKGYGFVSYTDFEASDAAVESMNGQFLMNKAITVQYAFKKDGKGERHGTQAERLLAAQARKNNALPVSARPPPAVMPFGAPPMAGYQGPYQGQFAGALAQPPPPPGFTPQQTIMPQMPMQMQMPMAPPSMPMQMPGMAPMPPPQGMSMYGSFPPPPPPGFAVPQYPGQLPVPPPQPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR24</accession>
    <name>A0AA38JR24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_364995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR24"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="24028" checksum="1CBAF25480EE5E3C" modified="2024-01-24" version="1">MLRAATIRTRHFFNSPLLIRSFTQSNTRSDFHFDTHQFVQRLEREGLNRAQAEGIMSAMAEVIDESIRNMASNMVTKADQEKHHYTQQVDFAQAQSELQLMEKNDLAMIKAENDRLVNDIEKLKQRLREEITRTQAGVRLDLNLEKGRYRDESSGKELKMKEVEYKIEQEIAGLRTAIQASKATTLQYLVGIVTGCSALLMAYLRFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR93</accession>
    <name>A0AA38JR93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_521814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR93"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="86"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="361" mass="40650" checksum="300EA29626BD852B" modified="2024-01-24" version="1">MFDEPSSYLDIKQRLKAAEVIRSLLTPDCYVVAVEHDLSVLDYLSDFVCCLYGKPSMYGVVTMPSSVREGINIFLDGFIPTENLRFREESLSFKMVENAEEVIVDKTRHYTYPAMTKTLGSFKLTIEAGSFTDSEIIVMLGENGTGKTTFVRLLAGDTPDIETDKQTLSVSLKPQTISPKFPGTVRMLLLKRIKQAFMHPQFQTDVLKPMSLEVIMDQEVKTLSGGELQRVAIVLALGMSNVNVYLLDEPSSFLDSEQRIIASKVIKRFILHAKKTAFVIEHDFIMATYLADRVIVFEGQPAIAATATPPQSLLTGMNRFLASLEITFRRDPTNFRPRVNKLNSIKDREQKAAGNYFFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRH1</accession>
    <name>A0AA38JRH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1017328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRH1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3736924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="569" mass="62154" checksum="8667DC494499C9E2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRL4</accession>
    <name>A0AA38JRL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_328604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRL4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="396" mass="42357" checksum="DD5B45721BDE9BA1" modified="2024-01-24" version="1">MPKASSLLPLIGPVSSGIIYCSGPFITPVITRYPYHKRTSLYIGTILCWASLFTASYTSQVVQLVVFQGVLYAIGGSLLYIPCISYLSEWFNHRRGLANGVVFAGTGVGGILLPLILPPLLSSYGPPKTLRILSIAIVLLVVPLLPFIKGRLPESRNRAMGPSPRGRGDVEWKKSVSFWVLVVANTFQGFGYFVPIVWLPTFASDLNLSSTTSSVAIALLNCGSVIGRLATGYLSDKVNPWLLGFSTLASTSAVTFILWGLLSYNLAGLLSFGVAYGFLAGGWTSSWNGFTKPLSASDPNLSTTLFGILLFSRGMGNIFSTPISSALTSLNSNSTTSTRGSNHSAHLGFDVGGGRFEKMIVYVGICFASAALITLVGWGTDVTRRRRALGRQGAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTX4</accession>
    <name>A0AA38JTX4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1036491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTX4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="213" mass="24148" checksum="17BF8CE8F593C091" modified="2024-01-24" version="1">MKKRASKRVTVSARVLTSRQGRKEIAAATAKKATKKKANEEKQKRKNDTLLADVLRRAEQDRLEVVFSGNMKNMPKPQLIDIANALKIPHEKATVDVLRVRLNAHFAAHEELKDDRRYSELFKRTRKRKEPPKENDSAALLGITQGFGTRGLKAFGTFLSTQNSNPLHQTLSYFSNFGHQDFPGKIDETFDFVQNISKIFSEVFGTMTSLGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUL4</accession>
    <name>A0AA38JUL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_987044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUL4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3737803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="237" mass="26149" checksum="347064B18F348451" modified="2024-01-24" version="1">MSTNGVPVPPPQPSLLKTTASSNGTVPPSVFTLPQTAQLEALYTIIRDKDTSRGDFLFYSDRIIRLLVEEGLNHLPVVKKTVTTPTGSTYVGVGFEGKICGVSILRAGEAMEAGLREVCRSVRIGKILIQRDEETMQPKLFYSKFPQDIAKRYVLLLDPMLATGGSAIKAVDVLMENGVPEDRIIFINLISSPEGLRTFSEKFPRLKVITGWIDQGLNEKAYIIPGLGDFGERRYCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUT4</accession>
    <name>A0AA38JUT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAIB BAIF family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1068431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUT4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="478" mass="52058" checksum="2B3A2C0B42E16721" modified="2024-01-24" version="1">MLRNIPGCNSLLRCYSSTNTIARMSFVNGNVKFRRFNASQASYNGVQEPRGIPSPLAGIKIVDLTRVLAGPTATMLLADLGADVIKIEHVGKGDDTRSWYPPSAPLLPQSSSESLPERAHSLPPESAYFLSANRNKRSVTINFKDPAGLKIIYRLIEQADILVENYIPGKLAKLGLGWEKCHKINPRLIYASITGYGQTGPYRQHAGYDVIVEGEAGLMHITGEPYPAKPVKVGVAATDVATGLYAHGAIMAALIGRERTGKGCWIDCNLFETQIAGLANIASSYLIAGQEAQRFGTAHPSVVPYQVFPCKASEGQDGDDFIMIGAGNDNQFNTLCNLVLPLPSLPSDPRFSTNALRVANRNELIKILEIELRKETKAHWLTKFKAATKAGKGVPHGPINNIKETFEHEQAVARKVTVEVDHPRAGPIKLVAPAVSYNGEKMPVKRHPPWLGEHSDEVLAELGYSTTQVEELRARGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JV77</accession>
    <name>A0AA38JV77_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_990400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JV77"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041354775" evidence="7">
        <location>
            <begin position="33"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="17"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="477" mass="51666" checksum="E3F695EF0EBAC082" modified="2024-01-24" version="1">MSSSSIIQPRTPLPKLQLFLILLIQVTEPITAEVIYPFIIGAVRNTGITCGDEKKTGYYAGVIESMFFLSECCTVYYWGRLSDIYGRRTILLIGPLGLTLAMLGFGLSKTFLALVIFRALQGIFNGNIGVSKTVMAEITDSTNMADAFTMIPIMWSFGSTVGPALGGILANPATQWPQLFGKFVFFRDFPYFLACAAAGVLAFVAFALSFIGLKESSPTFKNQKMKNVTSSDESEPLLLDDETQSNYGSSTSSGKTIGEHAQPLGVWELLTGDLWIVLLNYSLLSFTDMSYFVLIPLVYSSSISIGGLGLSPYQVGSILGIFAFLNGFWNLFVLTKILKKLGPRKMYIISYSSFLVIFPLLWILRDVAHLAGGVNVLVWILLVCQLLAAAFINTAYNSMSLLVVQIAPPNALGSVNGLAQMAASGTRGLAPLFASSLFSLSLESRIAGGHLVDIVLIVVSALGLFCSFQLPKHGFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JW07</accession>
    <name>A0AA38JW07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1047842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JW07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041255882" evidence="2">
        <location>
            <begin position="19"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="546" mass="58693" checksum="C616500C92241C6D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JW67</accession>
    <name>A0AA38JW67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_988100</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JW67"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="131"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3736985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="388" mass="43646" checksum="765BBFF52B80C26D" modified="2024-01-24" version="1">MASVSTLTQQLSTLDISKKQEPSAELSKLLTKYGAPNPPTKHKPSASTSNLRTKASVSSLKTVASQSSLKPKTKHTKASSVDAQKTIDIGRYDGGLEADNAAHVSVDEAPDLALDSSKLSNPTPTWSLHAFDIGRPLGKGQFGRVYMVRTKSPPQFILALKTLYKAQLVKDGCERQLRREIEIQMNLRHPNVLRLYGYFHDSQRVFLMLEFAGQGEMYRQLIKQGSFSPRRSANYVYQMADALSYLHSKHVIHRDIKPENLLLGINGELKIADFGWSVHAPGNRRMTKCGTLDYLPPEMVLDKEHGKWVDFWALGVLMYEFLNGSPPFEDLKSRKNTMKRIATVDYKFPPSFDADAKDLISKLLKLEPSERLPLTEVLVHPWVVRNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWB7</accession>
    <name>A0AA38JWB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_989047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWB7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="201" mass="22615" checksum="95857467A5034817" modified="2024-01-24" version="1">MSAVQALKKFRLHELKGLHGHISRFGPLSATESSSGVPLPNPFLPHKNPQTGRWAPPKYSLRRQAELIKKAKASNNLEILPPGPKMSAPAATVLSKRLDATVGSSQKLAVLDEALAFPVDWVGNPSHKSTDGSDLGARLYAGKKRMFKGHKWERVRERREAHHSMLLKDMDKRVRRYKKQHLKKRPNPLKVSRKTSTKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWS1</accession>
    <name>A0AA38JWS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_987077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWS1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="106"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="313" mass="35468" checksum="39FF35D08E53DB01" modified="2024-01-24" version="1">MSSSGIPTQASASALPEGITDPNYKPLPGRLGNLTIPQQHALEKLKKELQGEGVFVEERMDDATLLRFLRARKFDVALAKKMLLECEQWRKDFGVDDIVKNFDFHEKEQVDKYYPQFYHKMDKDGRPVYVERLGKLDFNALYACTTQDRLLKRLVYEYEKFIISRLPACSAAVGHPVETSCTILDLKNVSLSNFYRVKDYVMAASSIGQNRYPECMGKFYIINAPWLFNGVWTIIKPWLDEVTVSKIDILGSNYKDKLLTQITQENLPKDFGGTCHCEKGCSLSDAGPWNEPRWQKLEAEISNGTANGSAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWS6</accession>
    <name>A0AA38JWS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_26674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWS6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="95" mass="10826" checksum="7D1E310ED3A95634" modified="2024-01-24" version="1">MFPRLCSVSRRSIHLSRRATPRPRPVDYLGPSRRLSNMLEPQSLMMDLESEFFNSTTGRFLYVSCILSCLCSTRYATYSVPPTLITSESAGWLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K299</accession>
    <name>A0AA38K299_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1162865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K299"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="733"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3737528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="767" mass="86311" checksum="E67476B87F7529D0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MR76</accession>
    <name>A0AA38MR76_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1209894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MR76"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3717208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="492" mass="55527" checksum="BA86CDA847C9ED72" modified="2024-01-24" version="1">MVNTRSRCTHTTTKNSDNIQEEPVMANPFATNATAFVPFTESISGTGLPSFLGTFHQDYKFWQRFSPHCRALGHLTNSDYTVRHMIEFIWFSLGEFQEAIMLWEPLLSIVKDVLGMENNSTAYFMSGLAVAYFRIGKATKALNLLQNLIEIFKRIMGEEHPTTLHTIQGLSIILICLERTNEALVLLQPLVETSKRVMGNEHPQTLNMIEGLSMILSGLGRKNEALILLQSLVEISKRVMGVEHPHTLARIEGLANILHDLERKHEALEILQNLVETSKRVLGEEHPSTLNIIHNIASILIMMKRLNEALELFQTVAEKLKRVLGDEHPQTFIRIKSVADTLYFLGRKDEALELLWPLVKISKRVLANEHPQILSKIKGLADILYLLGRTNEASELLQSLVEISKRVLADEHPQNLSSIESLADTLLFVGRINEALELLLPLVETSRRVLGNKHPQTLSRNQSLADTLLELLQALVETTKRVLGDEHLGHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSQ2</accession>
    <name>A0AA38MSQ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_489801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSQ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3728971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32329" checksum="DDDA70855D4D6D43" modified="2024-01-24" version="1">MNDESSQRYYASKQYLLPADNVETKRLDTQHDMITNVFGGRLSMAPTTLITGDRVLESAAGSGIWALEFFEKNCADGIILNIDCIDISSAQFPTTHPPQIHFSVNSVVDLPNPEWSDTFAYAHQRLLVAAMNDSLWRSAVSELFRVIRPDGWVELVEIEAQDFSSWSVGPSSTKLASLINAMYGAKGVIGDLSVYLPAILKEAGFTDVKCDKRRASIGGEVDATPHKVTDVQGYGSGMWRELWMGMKGPVVEAGGYGIVETVQEYEALVESSAVEWKASKEAYTTFFVILAHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSQ3</accession>
    <name>A0AA38MSQ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1146623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3728986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="474" mass="53552" checksum="9CDF767F7A6ACFCC" modified="2024-01-24" version="1">MSTRWTVRNFLWGEAPSTKQERSLLLKLDFFILSYTCLVYFTNYLDRSNINNAYVSGMKEDLSMEGTDFNKVLTIFTCGYIVGMIPNNLMLQILPPRIWLPLCQIVWGVLTFCTSAVTNVQQLYAIRFFQGMAESSTFVGTHYILGSWYKPGELGKRSGIFTSSGLAGTLFSGVLQGAVYSNLNGVSGRSGWRWLFIIDGVITLPIAFYGFWLFPDVPATTKVFYLSEEDRQLATTRLRGYVEVKHSPLSWKLAKRVLTRWRWYACSLLFAISGETESFGSNNLMGQWLKAVGGYSVEQTDYYPAGVTAFGIFSTLVCATWTDYTQVRWPVLLYMSGSCIVASICILVWGSPTGLKFFAYYLAGASYSGQATTFAWANQICADDDQERAIVLASMNMWNNVVNAWWSIVFYPATDAPRFKKGMIAMIVICAATIAVTGLVWYLENREHRLGRRLENRTTSENEQEEKQTVVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSX2</accession>
    <name>A0AA38MSX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_460997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSX2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040887">
        <property type="entry name" value="AUDH_Cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054583">
        <property type="entry name" value="Beta-prop_AUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22301">
        <property type="entry name" value="AUDH_beta_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18637">
        <property type="entry name" value="AUDH_Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldos-2-ulose dehydratase beta-propeller" evidence="2">
        <location>
            <begin position="107"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin" evidence="1">
        <location>
            <begin position="417"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="97228" checksum="2705ED619A7489F1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTK2</accession>
    <name>A0AA38MTK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1076750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTK2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="959"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111080" checksum="EC14C82955FE5066" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU72</accession>
    <name>A0AA38MU72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1223989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU72"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47072:SF4">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="334" mass="36871" checksum="724CE07B775F2464" modified="2024-01-24" version="1">MTDSEDTSQAAGMSGDESKSISTAPTTSNSQGKRANSNNAKWTQKDDQAFVKGLIHARKLGMQTDSGWKASTWPIVLEFVQKEGSNIGGPKNTKKALDYFGKLKTSFNQVTELRALSGVGWDDVRKIVTATDLVWDAIFLKRDIKKFGRWRKTPFPIYDEMAELIEGVVANGENAFIGGASQAPYEDRSGDSSGNETEPDPVPTKKRKRATSEESIPPLLSHSSSSSVTLGQSSIHSKRIHTRDRGTPNAKAMHRVADSIDSLGLSLRGDVSTPERRRQAVKQFEADGEISDDEADSVYDLFKHDTSAIDIYLGIGTKERRSRFLRRQIEKNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUK3</accession>
    <name>A0AA38MUK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1153559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUK3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="335" mass="36773" checksum="1B7482E3F477D03F" modified="2024-01-24" version="1">MSRNVVSMFLLGATGYIGGSVLAVLRERFPGLKITALVRSETHFDAIRATGITPIHGSFENQALITEHSARADVVLNAADSDDLNLTLSILRGMKQRYESGKPKGILIHTSGVAVFLDSETTGVFDKNGKLWNDSEEDDIRSITPSMLHGHIDVPILNAGNEGYAHTYIVCPAAVVGPSLGPIGKSSFFVKAVVQMSLVNKRALYVGEGSNEFNIVHIDDVVDLYCRVFELSTEEKGLQSFNPYARYFIATSKSISWREIATFAGASLYKRDILKRPEPLSVNLTDLPPYFAFLAASERIVAVRGKELGWAPRDVSLERWFQANVDAVLEGLHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW70</accession>
    <name>A0AA38MW70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1057549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW70"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF5">
        <property type="entry name" value="DEPENDENT EPIMERASE_DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="323" mass="34692" checksum="32180EEE32CB7AF6" modified="2024-01-24" version="1">MSTYIQNKLVKGEKLQFFITGASGYIGLAVTEYAIAQGFSVRGLSRSEEGDEKLKSLGATPVRGDLTTHDVLARESAAADAIIHLAWNHDWSADYSKIVDADIAAVNAICAAIKDTGKPLVIASGCAGGQPNADGSETDENAPLRQNFIVAKRLESETNATAKEGIHGIAIRLSPYVYGHGGKGFLLMQIAEAVKLNESLYINDGTYHTSTLHVEDAARLFIAAVLKGKAREAYNGVGQTDVSLKDMAEAIGKVVGVPVRSVTPEEAAQKWSPFLAMFNYLDVRSSNKKAREFLDWKPEGVDYITDIVSGSYAPVAAQLKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWS6</accession>
    <name>A0AA38MWS6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1096518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWS6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="258" mass="25900" checksum="55D25A901F4BD704" modified="2024-01-24" version="1">MPEAMEVATPPMYVAQGSFLPFTVINTFFKSLWNLDAFADYCRRLPAPTKKKLETRRPMMTVFSKLQLVLAFAALSLSTAAAVAQGSLESESTTSAPLLVTATSIAVVTAVQTSFTIVPGSSITSTDLITSISHPPESSASITVATPSVIISSVSRTNANSTPTSLAVASTSPSSTVSLSVGSGANKGVVPVSSGFVVTVTSSTNAVESATASTGSGAGSALGAASNGAFGAYESIPRLSAVVVVLSTLLGGAIAIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXC2</accession>
    <name>A0AA38MXC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXC2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="100" mass="11452" checksum="6AEFBD72C951E7E5" modified="2024-01-24" version="1">MSRVMYKQRSPLQYYSFIFRNWTPSLATWGVGVGAGALLFLSVTPLVRREVLSKIPGVRQQFYIPYHTRVQISFARLRATIQTIPPLPTNPSDTSKRSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXH8</accession>
    <name>A0AA38MXH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 6/97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1089340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXH8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3725003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="106" mass="12163" checksum="34402573804910EF" modified="2024-01-24" version="1">MFPTVSLTSRPLDLLYFCFFLIHIPASLLLDFQILYPSAYVPSFLLALRQWHIDFSADPLITGAVRGEINGNLSWLGCFAWLELIFQFPTFLLGIRGLWRGTHDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXL1</accession>
    <name>A0AA38MXL1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_716251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXL1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48805" checksum="45535B55C08F4108" modified="2024-01-24" version="1">MDNTITLPPGYDATITSGNNRDADLPAYSSLSSMGQVVPQNLTELSEGAPSKEFSYHISLKGNNSSASLVLYGNASLSKHSPAFLGGSRVNGLVKVNVESGESINAVVISIQGKIISGSKQHIFLEYTQTLWSSSSDYHKSDGKLQGEHNWPFKLHFPKEVTLTVGTKDVPRVEVFHLPQSFMERHAKASIQYEVIARFARGMLKTDHRIIAPFVYIPIIRPEPPSQLRSDAYERNTTIPGPIADPTGWHTLTPVQIQGKLFTRQATISCTLSLALPLSYTRGSVIPLHLVIQSNDIQALETLSSPHAIICRLRRILRYYPDENKTVDPKLRREELEQSELATWWPFVESPSLEESSFQRTLSGEIILSPELMPTTTIGRFQLEYSVVLFPFDANSFHPENNDILSDCAVEIATAFPPGPRQRMNVQTAIPDRLRHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXT7</accession>
    <name>A0AA38MXT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1129087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXT7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="481" mass="53872" checksum="41980E81211B7A7F" modified="2024-01-24" version="1">MGDFQVVDPKGWEYDLHSVYSAYIGHFQTHHIPWYEKSWGHLFSTFEEFLAFSWPVIVVTDARTGKAHIVTRLTSIGAFLKMIKTRFGETLPQAANMVIIQPFETTTRHLRHVSDHATYRKLYNTLPAAVLNATKQRIRNGEPDFIQDIWDKQDKTFMAIDFEWSERNEKSTLEWGYAAVRCGPLKSLGVWPPVPDDNYRKGHYIIQEYADKVVNKYCPTYPWHFGDSQVISKTKLPQVIQAIISSLASPDIETLSNTLVLVTHGASGDLARLEEMKIKLPHNMFVIDTAVFERNLYNQGLRPLMVDPKTSQERQPGSTLSLENLLRSFAMSSQMDSIVLPNVKFHNSGNDAFMCLFALQMLLDPKGVKVPTPKRNNRGNNMLGLGVTIPMTMTPSPPSLMIPQAFFNGYATVGGLPTPNGSIPGQRTSVYDLSSEFGQMRMGSGEGSRRSASKSPGSRLTPGGGSARDSRRLSGFRFGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY98</accession>
    <name>A0AA38MY98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1042001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY98"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3723528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="256" mass="29108" checksum="A3166A3BBDA6FAD6" modified="2024-01-24" version="1">MARNVSGSGWVDMGTLKAGCQLLIPNPNLDALEELWGYVITNLEDRDITDEALKKKEFLRCFAKWSTLKETIAEISHSLPSKAWVEVDTSSTDPDDFTCRPFFDAIRDKILGNDWARIYDLKRDKYVMLPDATGFSKLVTLMETHNRRLRGTMYHRSNEVLQTLIMQKLPDKFRADLRDCKVSENLPYADWKTACKDVEERRPPTLSTTAYGPKRADSRLDKPMNASNNTAPGPPNSSAFQISETTPRTKKIADQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYW7</accession>
    <name>A0AA38MYW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1155659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYW7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="224" mass="24683" checksum="EA18024BC9A9A820" modified="2024-01-24" version="1">MPFTKWQKPTRKLSVGHNPNMMVSSVLQETPGNSWTPGTPGELQNSWGTPGTPGTLGALGTPGSSWNSWKLLELLETLGTLGTLGTPGNSWNSWKLLELLETPGTPGTPGNSWNSWNSWNSWNPGSSGNSRKLLELLEPWELWELLETPGTPGNSGNSGTLGTLGTPGNSWNSWKLLELLELLEPWSSGNSWNSWNSWNPGNSWNSVQELFRSLYISHQFPNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ20</accession>
    <name>A0AA38MZ20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1085317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="480" mass="55019" checksum="2C8DCC53F8870252" modified="2024-01-24" version="1">MAQLPDLPVEILSCICDNTEFASLFSLARTCRVFNQLAERRFLQLTKFDVQTRHLNIVSEQELQLSDSKDAFSFNSARRLCAFFGTLLNIESLTCTFPLSSSLATIRQMAYLVQILRTISAQQGPRDSCPFSIVLEFDGDPGPSVKAQHESRFGQVFRSLLCEIRRLRCDSLELRDRLPAFRNAVSLELPIDDALERISIGGSWLFSWSRPWLIELLNSSSKLSSINAKCSKIWTEILPKLCLPALECISFYWYLDDTEASNVKVFVDFAKRHPCLGTLDCGEQFVVTWASSRCTELLSNISTLRGTISQLRYFLSSPDTSLRKLEDIEIRGKSAPARYRNYHSWEPYNKKYPLWELFALISTRPSIVKVILPMDLAGFQKQLFPEFKQGRLSITTRSTLPRIRYLVFKRSLTLYVESIADFVDWACQVFPSAERLEMLDSDRTLGRPLVQCVKGQWPSIHHLVMDDHVYAVQDQNNDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0D9</accession>
    <name>A0AA38N0D9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1076489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0D9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="432"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="478"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="571" mass="62990" checksum="4E13382B2EC82562" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0K8</accession>
    <name>A0AA38N0K8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar assembly protein DID2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1071593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0K8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="203" mass="22701" checksum="F95A9D1277D66443" modified="2024-01-24" version="1">MSNLEKTLFQLKFTAKSLNRQAKKAQKDENSEKSRLKKALQQGNNDGARIYASNAIRKKSEALNLLRLSSRIDAVASRVETAVTMRQVTGNMTSVVRGMDKAMESMNLEKISFVMDKFESQFADLDVQTSYMEDTMSATTATSTPQDQIDQLLKQTAEEANIELQHDLAATDLDNVPDLTVPKDKIGEEDDKLAERLRALRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0P5</accession>
    <name>A0AA38N0P5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_278333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0P5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="695" mass="80443" checksum="9755561DDA7A0AEE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N197</accession>
    <name>A0AA38N197_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histidine kinase-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1154352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N197"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="230"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="717" mass="80335" checksum="9B66373371F1B1F5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1A1</accession>
    <name>A0AA38N1A1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease T2</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_996560</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1A1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041271612" description="ribonuclease T2" evidence="17">
        <location>
            <begin position="25"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="18">
        <location>
            <begin position="309"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3732647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="427" mass="44174" checksum="BF6C94C997791082" modified="2024-01-24" version="1">MTSHLTLSLVLAAFSAFGFPSTSSNPLGLGGQFDVFARDVAISSGCANTGTASCHNTSAVSNTCCFEAPGGLILQTQASNFWDTDPSTGPSNSWTIHGMLHCLWPDNCDGTFSENCDSSRDQTDITSLLESAGASSTLSFMQTYWKNDPDDGSDEELWSHEWDTHGTCYSTLRPGCLPSGSPSGTDAVAFYETVVRLFQTLPTYTWLANQGITPSASTTHTLTSLENALAAEAGFKPMLTCDGSNLNQIAWYFNLKGSIIDGTFVPIDSPEDSDCPSSGIKYPLKTGSPVTTTSATGTKTSTTTTPGSLPTKAMIVAIHNGAQVGGLLTLGTWSTQTLATMTLAGSTSGFTMTSSKGSCGVSDGELTCGSGVTATSFTAVSSSGNLLLVSGGSTAFSSTAVPSGETVETVFTGSSETQTYTLAIVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1B6</accession>
    <name>A0AA38N1B6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Male sterility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1072343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1B6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="71"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="449" mass="49977" checksum="33A1051C0C8E2B8C" modified="2024-01-24" version="1">MAIFSHDFEFFSYPTSKGLPVQDIVQHAESIEAMVSKYSAGLDDNNDDSLNSPTSSCSTRKPSAVNEIVLLTGSTGNLGCYILASLLSKDHVRRVYTFNRKSTDRNIMDRHKAQFEDKELNVALLSSPKLVHLEGDVTLPGLGLSEKVITNLQQELTAIIHNAWNSNFSSPLSSFEHHIKGTRALIDLARSSSRRNAIRFLFTSSITMTQNWDESQGPYPETLVMDAMTAVGGGYGESKYVAERILAKSGLEVISLRIGQICGGEPNGAWKSVEWFPICVKACWYLGAIFVPSHETNWMTMDSTSDIVLEIVFHKDPLPFAANLTHPRPVSSAFILHAVRDALIQELGHGLSPESLRQVSVKEWIDMLERSAITHNAEPRNISRLLSKIIFKLPSFVTLDISNAIKLSERMRTLEPIDARLVSKWVKFWIASGDLGQSGFCEDRSRAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2G2</accession>
    <name>A0AA38N2G2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_31308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2G2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="288" mass="32263" checksum="3AF35A51C4154D68" modified="2024-01-24" version="1">MSSFVSSVLPATSTPPPKRKLNTTISECEAIPLSSPSSRRRLSPNRSRRKPYSCYVKSPLKGQQMPSTEEVMEIQKPKSKSDNEGATQTLDRASNPMFPSTPEASLKHKHRKKLTSRMICPGIRSKTPVARHLRVLSRHIRHFQISIASNEGGECDSEAKISLTRIPSIMDVYLDAKSPSIDFTEEVLLEIADRIKRLSQFSSPRFALASSPTQRHCLHQNCECEYRHSAKSDSEYPALDSEMTALNPFWEEIWFGKNATGLGNSTRHPDSFERSTAAWSDSEGLNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2J0</accession>
    <name>A0AA38N2J0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_206784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2J0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041414412" evidence="1">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="2">
        <location>
            <begin position="50"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="224" mass="23856" checksum="1333B9504D6754F0" modified="2024-01-24" version="1">MALPAIHSFFKLSVLTFFILAPAARASEWIEYSSNGFATLTHYSLPLNYIASCGCTAESTHYPTAALSQMAFGSSTAYGPACGRCFNLTLLNTFLSVPPFYPSEQKSIVVKVTDLCPLSTTGWCNATTNGPNAAGNYLNFDLAYPSTSIPSNFFPSNASYYGYTDFGVWNISYESVSCNGWEGWNDAAALGSVTGQGPESVCCAADPTNSSNTCTSYSDHNGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2N8</accession>
    <name>A0AA38N2N8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1059479</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2N8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000156">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="133"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="393"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3735360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="539" mass="61604" checksum="DA6F8DEB497CF6E3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2P6</accession>
    <name>A0AA38N2P6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1130251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2P6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000401">
        <property type="entry name" value="Related to MTD1-methylenetetrahydrofolate dehydrogenase (NAD+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="1">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="2">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="366" mass="39676" checksum="8FBE6F8936CFFA20" modified="2024-01-24" version="1">MSTSTSVSGKGLLLKADSIAATFRNEVEKTLANCSHAPKLVGILSTSSSPSRTYAEFTRKQCESLGFKFVLKETGAALPNEGLGEGEGVEEAIMEANEDDSVDGVMVYFPIFGPQQDHYLQQLVSPYKDVEGLHVKFHYNLYHNIRFISPSSLSIPTASATGSTGDEAENDIPPPGMVKSILPCTPLAIVKCLEYAGVYNKILPYGDRAYGKTVVVVNRSEVVGRPLAALLSNDGARVFSVDIDSIQEYTKRPSDSDSSRKYHPRHIVRPPPEAYNTLEACLAVADVVVSAVPNATYKIPTAWLKDGCVCVNVAAEKNFEKDVRDKASLYIPAVGKVTILMLLRNLLRLQQYKNVSPSSTAGSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N301</accession>
    <name>A0AA38N301_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1131125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N301"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34242" checksum="A970EBD6259E69FC" modified="2024-01-24" version="1">MMELDGSQSTALVEVNREERNYHPSFSSPDAEVVLAAKNDFVAKASVYFRLHSHNLKTASGFFRDMFLLPQNSQPDDGVFYLDEDASTLELLFRMISGLPIPQIDSYDTIDPLLDAIEKYDTPGPLSVVRLLVMTPPLLGQPFRLYAIACRFGWDTEAQYASTQTLSYDLYDKEIRKYLSRLSSAALLRLFDLHRLRREGLRQRLNDPPFVSGGLATCNNCNAVIDYHTWRELKYKIILEMDVRPLGDTILEQGLSGWPEALACWQAKCVQTGCSRALYDKVETLRVIRECIETLPRSITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3G1</accession>
    <name>A0AA38N3G1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_110907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3G1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041423644" evidence="1">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="147" mass="15544" checksum="04388C6B5EC38525" modified="2024-01-24" version="1">MFAKVFVLLAALPAVFSLTLDTPTNVTSGLVSNVTWTATDSDPTFTLELNHPSFGNSLALANNVNPTSGSPLNIEWPIVPADSGYTLSAVNITDINTVFSTSGSFSIAQAPTTGVSASVSTTFTVSSSSGVSASHRLFWLYYWHQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3P4</accession>
    <name>A0AA38N3P4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1054256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3P4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="301" mass="32602" checksum="2C141CBC3CF34D30" modified="2024-01-24" version="1">MTPIRTQWTRLIRFVAVETSRVHIGEPVDPNIDVGVAVHQGTPIKAHEIIGSALDPAAQVSGKILTVKYLLSPLTRSEVGFVRCLGLNYTDHAEETKMAPPAFPVLFVKPTSSIIGTEGTVIIPAAAQPVKEHLPDYEVEFTIVIGKAAKDVKEEDALDYVLAYTGANDISFRKHQLAVSQWCFSKGFDNTNPLGPCLVSASAIPDPQKVSLKCKLNGETVQDGTTADQIFQVRRTIAHLSQGTTLEPGSIILTGTPKGVGFARKPPVYLQHGDRIETWVGGGIGTLFNDVKEERETLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3Y0</accession>
    <name>A0AA38N3Y0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_991280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3Y0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="77" mass="8841" checksum="D0BD6DB2F8155F5E" modified="2024-01-24" version="1">MSAASVEAVDGTAPPSMRDTQQATHEWRDRKESESRNNRYRVIRPGVVFDVPQDPHQDKQNLRYVKTSRSTRASNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N473</accession>
    <name>A0AA38N473_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-mannosidase B</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1199697</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N473"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="16">
        <location>
            <begin position="37"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="13">
        <location>
            <begin position="213"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="15">
        <location>
            <begin position="704"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="14">
        <location>
            <begin position="809"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3736516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="890" mass="100689" checksum="835884DE7EF95324" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4X4</accession>
    <name>A0AA38N4X4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_4622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4X4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="336" mass="37105" checksum="BA75EB5CDA8A0E3E" modified="2024-01-24" version="1">MPSPMASDSARCKFLFHSYLLRSLYGIKSPQDLTKTHHHDTYPAISPKKPALSQAGRSVLITGGGGGIGFEIARSFAKAGASRVIIVGRRSSVLDAAAVKLREEFKDSSTEFIARQGDIGDDASISSLWDFLHSQNIFVRVLVLNAAHVTPWGPDTLKMDKRELMEGFDINVGGNFVMMVKFVNQPLRPTGQQLNLIYVSTAGIQMIPAPNQTPYTTSKAAITALVGRIADEHPVEDIQIISYHPGTLYSEGASKYVDKSLLKWDEMALPADYAVWAASPEASWLHGKFVWAHWDVDELKADKDISKLMEQEKGFLRVAVQGLTEVSLERFMNKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N577</accession>
    <name>A0AA38N577_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1049724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N577"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="376" mass="41689" checksum="9EC1C281DCBD3326" modified="2024-01-24" version="1">MDDPLRAWYGSSLIFFWNIYKYFELFYNTKESSKIHPAYRSTLQTHESASIHKFLLIQGLISTFWAITLIIFSSGVVPIYWGLSQYGTQHTGVTNVIVTGVATLATSHLHYTVQHAAAEYVAMGFYNGITLERWSYMQGIAQGSIWPPFEFKWNQWKHTWKQKLAWLLWILTWSSMGLHSASISAILQPQPTYQHVLFDDLIPCGVDPNILSVNSSLNVTVQSQLDQIAFGVGLQLGSYYNQLAGNTTTAFATRAFVKDNYGYAAIGGLINGLQEMPGVAINAQCSNTPHSPPLASLWSSVFPGLSLPSINTINGSSYFNNSISITPTSSQAIITSAPTFNLTGVEIREPSVVSATAIIFIAGTRFDEHSRFIFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N586</accession>
    <name>A0AA38N586_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_514410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N586"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="302" mass="33280" checksum="39EDB8EF3E05C2E9" modified="2024-01-24" version="1">MPLEPISLNDGNEIPAIAYGTGSKMKYHDITQYIEQAIEMGFSHIDTAVFYQTEKYVGKAIKESGLTRSELFVTTKYPREVPIQKSIKESLANLGLKYLDLYLIHQPLFIPDLVEAWKEFEKVQQDGLVKSIGISNVVNVQQLEHLIKVSKVTPAVNQIELHPYNYHKMKSIMDTCSKHNIVVEAYSSLAPITTYPGGPVDAPLRAAAHRIGATPTQVIFLWVRAKGAVIVTTTTSKAHMAEYLAVAELPALTDEEVASIDAAGAKGPPSGIVTRLRLMNTKEKLLGVVAGTQCSWCMELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1L2</accession>
    <name>A0AA38J1L2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000114">
        <property type="protein sequence ID" value="KAJ3711856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1L2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="390" mass="43764" checksum="FED00EBA13B1E680" modified="2024-01-24" version="1">MSNTTSPPMVPFPSTGVDLSSTFDAFFYGVIVSVGLFGISVVQLWTYINLSRDRWMFRVVVITVFLMDMATTYLDIGLLHSYLSSSNHSPLQVTHFGDLTIFATPETLLDLEILFTALIVFVVDLYFASRVHLLKQVHWSVVAFIVGSNVIALRKATFWSSKSDANSSVGRSYQHLYGYYIPHSSSRMFYFFFVVSIIVALENAVTTVCEVVATVALAWSLHSSRTGVPRTAYKVDLDRVPHVFKQVVFHHHGLNTRSSLRRRLDRTITDSEVGRIIQQSGHSFARGTSFVLGSSIDANVNTDPPDFGLTQISTHDTEILDEHESVHSIKGRPGVGVENNSPDSSPADCHNQKSHLYCGLSIYRKKLELGKQQLVVRSVTRRYCWIRMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1Z1</accession>
    <name>A0AA38J1Z1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PX-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1165509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000102">
        <property type="protein sequence ID" value="KAJ3713038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1Z1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="271"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3713038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="87581" checksum="AF02597B38168D0A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2F7</accession>
    <name>A0AA38J2F7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_887781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000094">
        <property type="protein sequence ID" value="KAJ3713986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2F7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041352088" evidence="3">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3713986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="252" mass="25030" checksum="27C236B952CD9DD3" modified="2024-01-24" version="1">MVPAERSLTIIFMGLLLGFDSSHALPQQASVSLFEFMSVVSGSNPTAVIGTEWAQPLGTASDGSQTTFIVENVYTTSVPVSSGATELTAIPVTGIETIVVSASGWAQSNFPTTTAAGSLQLGGGVDCHFTASASGECVEEEVLDDGSTSTRTLTGDVITQILPISTGTLPVGVGATTTSNAQSTITAVSQTSPTSRSTITALSSSGSSSASGSSASTTTSSNDSLSVHKALGAGALTALVGGIIIGVSVVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2S8</accession>
    <name>A0AA38J2S8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_876451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2S8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="500" mass="55334" checksum="014981F498847204" modified="2024-01-24" version="1">MFDIPSDIDSFDFDTIGSTSLSTPTYSLVPSRTEITLDAKRLDPHGPSWVYRTKHMTIDLGRRFWGTSSPAYGLHDKIEGLVKLTGHHPELIEDISVTLEGHLATTVLADGGVARSNTLFMHHAVSLPLSSHPAEGDEYPFVIPIPSEITLQGLTALTPPSFYRLHLGVTGEIAYSLKVTMTRQATRMSFKHEPTESQTIPILYFPKTRPSDPPLADIPKPLSDRDPHFTSPSVNIAEHVDTFPLSPRWSYASSHAKHPLTPFQNSVFFSMPAPQSFASGEPIPFFLSLVFPDSPAQASLYTKTITVTLMKQLTVRSAKSHLRKLFSRSKNSPSRFSSPKNSRNSTPLHSRSTSPIPLGDDSDDASSHSDASSSSADLDAYGPPVVRRWVLSSGHLETRSEYSEGVYLLRGWISAGELGRGCSWQVGRIGRLQYFLEVEIASPASMEDHIPAFHLEKEVEITTDCWETMNRELQSMGGVPTPALGLERCLLEKESEYEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3M3</accession>
    <name>A0AA38J3M3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1134414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3M3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3717662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="86" mass="9350" checksum="99F38FFF815C7101" modified="2024-01-24" version="1">MENDQGVLVDLYVPRKCAATNRLITSKDHASVQIAIADVDANGRALPTTTTFALCGQVRSQGESDDSINRLATKAGLLRNVWSYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3S2</accession>
    <name>A0AA38J3S2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAGE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_774958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3S2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="83"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="452" mass="48865" checksum="F22F7B943901341F" modified="2024-01-24" version="1">MARGGTTSTQTRSQRTKPSRASQGRGRPQPKRDTRAQHADSGEENEDGDGDDDEALHDEMDVDGDGGGGSQDGVDINLKANQLVRLALFMEHRRMPLRRDDISKKVFGPSSRASRPFNRVLERAQFILNRTFGMELVELQSRAALDKAAAAPDPTALNEEQEEEEEEPAATQGKGRGKATGLKKKALPVGGKSYILRSILHPTIISFAALPDEEILSAELDDAPDELNDDDDGTPAPSQTPGGHRQRAHSASNPSPQTCTGTLLSFSSSTLPALENVGALGVQYVLLSLILASGRLMSDRELRATLRQLHLPPGASVPLGRSAHNHLPGTGGNSNVTIEAYLQLLMRQGYIDRISSDEAGKPVKTSGGKRGRAAANIDAEDGENKYDWRWGPRAHSEIGEKAIQEFISEFMVEISGRQDNQDDGEGARVQERLKKMMNGIEKAAGGNISDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J457</accession>
    <name>A0AA38J457_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1097501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J457"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="210"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="633"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3719147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="810" mass="90762" checksum="7A649748855520D6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J478</accession>
    <name>A0AA38J478_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1096533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J478"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="188"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3719629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="393" mass="44585" checksum="943EF78EF70FAA34" modified="2024-01-24" version="1">MSTSSMAVDSHPPAPKLVLDEFIGTALTSTPPELHPFFESFRTLHTRKLWHQLTLKLFEFVDHPLSKPFRVDVFERFVTDFESKMNQLRLVELGVKVSKEIDNPQTHLTFLTSLLTRINKETSPDAYILLYANIAHAKLLYGDLEGTKADMDEAWKILDSVESVENGVNAAYYGVAADYYKAKADYAPYYRNSLLYLACVDPATDMTAEERLGRAHDLGISALLGDTIYNFGELLMHPILDALDGTTYEWIKKLLFTFNEGSIGKFEALAPLLPQEPILQEHYPFLRQKICLMALIESVFKRSADNRTMSFTTIAEETRLPTDEVEHLVMKALSLKLIRGSLDQVDQKAQITWVQPRVLSRQQIGGLAKRLESWVNKLNVVEQRIAPEMLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J517</accession>
    <name>A0AA38J517_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">37S ribosomal protein mrp10, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_652081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J517"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3723473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9144" checksum="96B2A83336AC58B3" modified="2024-01-24" version="1">MAIHIKNLKVRPRKNDINVMCAPQLTALLGCWAASGDFQSVVACRDAAQDLFHCMKTTPMPKKMHRPTINYHLARLGKKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5K8</accession>
    <name>A0AA38J5K8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="7">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1134048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000061">
        <property type="protein sequence ID" value="KAJ3720716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5K8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041363563" description="AA9 family lytic polysaccharide monooxygenase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="280"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3720716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="316" mass="33171" checksum="C741B2E1CF151451" modified="2024-01-24" version="1">MFTQLIALALMILPKARAHGGVLAIAIGDAWYDGWQPYDTPDGQTSIIRPWSSYNPITDATDPTLSCNDDGTSSALQLTAPINAGEEITAYWNIPWPHPYGPMLVYMAQCPGTTCTGVNSDTLEWFKIDESGLINGTVYDGFWGDGLMIADNSSWTTTIPATIPSGPYLIRFETIALHSLPAQFYPECAQLDVSGGGSQAPASYELVTFPGAYSNTDPGLTIDIYSNEAQTETTYPIPGPPLYGSPPPSSTTSVASSSTSSATGTGTGTSSAPSSTPTGPTVAEYGQCGGTGWTGGTVCASPFTCQVINAYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6Z4</accession>
    <name>A0AA38J6Z4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1035481</name>
        <name evidence="1" type="ORF">DFJ43DRAFT_1041404</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6Z4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3726419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="183" mass="20967" checksum="022BA15EF8FC0D42" modified="2024-01-24" version="1">MDPKSSHEELQPDQGKSVAHKNRFQIARDLFFACKDYVLKDDRLRNILVDAGTLSYLIYTFKLLFKFSMMFRSQPHAVTVGFTVPSVAIYAFIQRYAPRKLEETKSTTLQAAVDVTILAALTSDEEIYLTILPFMVIYLNLKYTGQSLATVSRMLLIYNDNARAYATDLYVLTLIFECRSYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7Q1</accession>
    <name>A0AA38J7Q1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1105233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000099">
        <property type="protein sequence ID" value="KAJ3713465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7Q1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="79"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="470" mass="51074" checksum="D80BDE278A092324" modified="2024-01-24" version="1">MTQLQTFQANSVAKTTSSATDTQKILAGRLFDPYKLQLLPSQTITVSKSTGLILTVGSTSENDTRTLASDEIIDLRHLTILPGFVDAHVHFFLHSYGETSWNDQTTKESLVERTIRATVHARKTLMAGFTTVRDLGTEGAEDADISLRKCLSGPSPLIPGPRYFCANRAIVCTGSYGPKSSLHKNQDGVEGIVGAEIADGVDECIRATRRQIGAGADWIKIYADYRFRSRMDGISPGISGAPLPTFGESELQGMINTAHSLSIKVAAHACNANTIATLLKLGVDSIEHGSTLIPHPESLMRLICATSSTIWVPTLAVSYYQVQLSGGKDPRANQAWKIVSEMFRHALAMGMDNIACGGDTGAFPHGENALEMKLMVRLGADWRKVLKWATLGGWECIRPMGWETSHDINGGYGMPLGDNDHRFGCLRPGWAADLVGVKGDFEEDFEATVDTVHFVMKAGRIYKKDGKDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J833</accession>
    <name>A0AA38J833_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_552888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J833"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3727225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="589" mass="63584" checksum="04D8FEC24A6737E2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9A1</accession>
    <name>A0AA38J9A1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Molybdenum cofactor biosynthesis prote</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1155035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9A1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="58"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="613" mass="67602" checksum="5366BCDDE768588F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9A6</accession>
    <name>A0AA38J9A6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1076784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9A6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="403" mass="42991" checksum="FC449D7622E9F06D" modified="2024-01-24" version="1">MTTHENKSQPLLVTVLASAISSVGYGLSLFAIGLIWLLPSAKPAVPVLVKSRRKPKHHRRRSAPPVLQSNLQRPPLPTFVSTSSKSSTDSPRRRVYFADTPIVQTPPPPTIRRHTSPPEDLHKNSEPLQGIFGPTSIVHVDASPRSSSSTLVHAPLPPTLPSTCIPILDANVKSEAAESEISRPSSSSSSSSSRPSLLVSPRFADKIKAPWIRKPAHTKPIDNLGITDSGVEATQSDESSCSAGPSTPVSKHKRKAASLGFSWPISKNKAAPENAPAFPSSPKTPIDSPLKQDCHPIPSPLSSFVRSSKQQRRVSAPVRARTQPYAYPYFALPPTVAGEPSFVAISPVVGSSDNGSLGSEDTSSVQEPEVTTNQRRPNPAAQASLGHGHPQRRALSEGFALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9H1</accession>
    <name>A0AA38J9H1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1182541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9H1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47231" checksum="44D548139B1DBA63" modified="2024-01-24" version="1">MATPGILGLNALDARHQHLLALDSYKNFNSLPCGLPAELWSIILDHLYDNKRTLLSCLLACRAWGDFCRYHLYELFTWSTVNKFDEDGCSTFHPYPHYARRLAISGSLLDDDVAEDSNIEWLLPLAQHLDQFVSVTHLEVDSMDWDDIFGTHAWDKFTSAKGFLSQITCLDFCNIPLHPFQHILESICLFPSLEKLDYLPSHVDLGEEIFDLQSYTPSSSWHAFSTEHSPLQLPTIGFWTWFSAIEFTSLQTIRLDSVPTSDLPSLSSYLRLLGGVLKNFRIRFITPHDVYEFVESNVLANSTGLQRLELVGFIRQYPNDQFWAGEESFNLLTMLPGTSLSGLDILLDGTPHRIADSVPSRLAAVDEILATSEKFSALNNVHLHLGRCNKANQEISKAFPSCQKKGLITVSTSNQVSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAI6</accession>
    <name>A0AA38JAI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1160332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000082">
        <property type="protein sequence ID" value="KAJ3715910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAI6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3715910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="372" mass="40328" checksum="B4D290EED74608FC" modified="2024-01-24" version="1">MIQTIRSPIYDPTSSLPDLTGKVALVTGSNSPIGIGWNIANQLALKGAKVYVHGRTLEKARAGIAAILRQGSDLSNTRKVAVNQLEPFVVDLGDLKAVRDTAVTFVEKEARLDILVHNAMAWVLDFNSAFIISDNNSLAYDSELDEYGISPSMTINHIAPFLLTLELLPLMKSTARSHPGVRIVTLSSVAHTFTTSGVRYDSLSSVNDNLGESADVLKRYAYSKLANVLFAKELQRKLDKAGIQAVSVSVHPGNVKTGGIFCIRSMLMFYLPPFSDGALKYFGPEAFSKLEGHLEPLQGALAPLFAAAATEVWTERDGGKDKLNWTGAYVMPYGVPSPVDESEAAKDPKLAKELWETTEKILAENVGISVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAQ0</accession>
    <name>A0AA38JAQ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_305433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAQ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="243" mass="26303" checksum="F87CA3735337BC5C" modified="2024-01-24" version="1">MPSSCQTKTNPISSVAVSDFLSQIKAFASRCSLAIRKHLRTMTTPGSYKTTITSNTKATVTFTSFGIYDLEAAANRSLDMDKENISCAPLSSEVDPHAKPNTSVDDIQSMLKLSQEEPEKPLALRLEVQLAKKILSRPPSLNGPPEAPIPQKFVGRAPIVSSDVEAEASSNESVSDVGASISTDASFDSSIPSSGEDEMDEPVLRPLTVPPWHFKSRRPNVCATNIEPHPPYTALDGPMRFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAS0</accession>
    <name>A0AA38JAS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAS0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00410">
        <property type="entry name" value="PHEHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="496"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="628" mass="69261" checksum="57D09B3F3E4210C0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAZ5</accession>
    <name>A0AA38JAZ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_995898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAZ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="211" mass="23954" checksum="41B751678808BB68" modified="2024-01-24" version="1">MASLGLTLGVLEIGVLISSTLYGVTSMQLYIYYKNGFKDKLWIKLLICWAHSASRTFETLHTIFIWIYLYRLSVQFYGNPTVIGELHWTIDMSSVFDGIISSLVQAFFAYRVWVLSQKLYLPVMVWIIAVIQSTGTIAIYVVSAQSTMAYFAAHDEWIATATLCCNVFVDIVNAGALCYYLWRPRREVPRHTTAVVDKLIVWTIGQSCSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB92</accession>
    <name>A0AA38JB92_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_366316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB92"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="173"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="321" mass="37388" checksum="4DB24D69DF3BFEEB" modified="2024-01-24" version="1">MICTETNQDNQTLPSVCSKVDGYSICFNSTDYPFYHSPRPTLIDGVSDPILTLAGPVLAYWALSLIFHYLDSSEWKWLQKYRLHESAEVQSKNLVTRAQVIWAVIFQQIVQTVLGVYWLSDDSHVDHVQGLNRIARYLAPVMAGVVGRERESQLLPSVSYAVYWWVVPTLQLLFAMFVIDTWQYFLHRAMHVNKWLYRHFHSWHHRLYVPYAYGALYNHPVEGFLLDSLGAMIAETVTFMNSRQALLLFVVSTLKTVDDHCGYRLPFDPLQMVTSNNADYHDIHHQVIGIKSNFSQPFFIHWDSILGTRMTRQELESRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBA5</accession>
    <name>A0AA38JBA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1077756</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBA5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3731844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="155" mass="17550" checksum="45D899C2DC821304" modified="2024-01-24" version="1">MSTELPYAADAEVSLSYDELEVLRLQYEREQLQSHVTVQTKFNYAWGLVKSPLREHQVEGVRLLQDLYRSEPTRRRECLYYLALGHYKMGNFEEAKQFNGLLMEKEPTNLQALSLGQLIEKGVTKEGYIGMALVGGAAALGTIVLAGLIRRATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBS3</accession>
    <name>A0AA38JBS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1067149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBS3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="109" mass="11696" checksum="C2D941CB71A94474" modified="2024-01-24" version="1">MFPVLLCIGLATRFKLTGNSQAPPLTIESISLTDMHKASHIINVSLPDFLQHYRRTGSPAMRNLSQSFALLTALSSVASSSVVCNVGSNDPIAFSEISLDYLVIGTQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBT2</accession>
    <name>A0AA38JBT2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000161">
        <property type="protein sequence ID" value="KAJ3709696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBT2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37950" checksum="A097C13CBE459EA8" modified="2024-01-24" version="1">MSPANSRANSPSDDEERAELLLIQKKKEEREERARKEAEQRKAEEEAEAAAEARLAEIRRKKEEKKKREAEEKKKREELEKQRAEEAKAAEAAKKMAEEAKRNEERRKAEEAAKAAEAASMKAEMERRLTTAALVRAQLEKKKKEVQVQSPVSEGSTVVAGKKRKRVTTVVVPSGDPEGGDPNPGDDDDYLESDTDDDEDPEVPPTSPPKQSRCSRCILKALKCEMVGPGSASCKGCRKSKVRCSLVPDDYPRRSKRTKMESPVASTSSQVIDDLRTNVRDLNTRINLQEEMLRYLILCVRKLEEANREEDEEEEESEEDRVKRTGDRKGKGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC62</accession>
    <name>A0AA38JC62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1087245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC62"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="46"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3727235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="447" mass="49419" checksum="614D6C715A33883E" modified="2024-01-24" version="1">MTQDLNALIDQSYLIVPSFTLECGAELHDVPVAYKAWGTLNQESDNVMVICHAFTGSADVPDWWGPLMGPGKAFDPRRYFIFCANTLGSPYGTGSPITVNPDTGKIYGPDFPPTSIRDDILLHKLVLDHLGVSSVAVVIGGSMGGMAVLEWPLCTPTGYVKHIIPIATSARHSAWCISWGEAQRQSIYSDPGYKDGYYTTQPASGLAAARMSALLTYRSRDSFESRFGRKAQIQKEARRPLTPPGSPKIRAEDDARAAHNDGHRNTSQVKLPSTPSGPSSPAPKTIFSAQSYLRYQGDKFTARFDANCYIHITRKLDTHDLARGRFIEGEDQDDDSAALARVLSTLPPRALVISISSDGLFTPSEQKEIAEHIPGAELVTVHSPDGHDGFLLEFEQINTHIMRFLMREFPRFYERKVDKEEAEEPVEGFEIKKTSLFGEAEADITHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCG2</accession>
    <name>A0AA38JCG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1135187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000133">
        <property type="protein sequence ID" value="KAJ3710766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCG2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="93056" checksum="A096BE4993D5B106" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCH4</accession>
    <name>A0AA38JCH4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1128464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000130">
        <property type="protein sequence ID" value="KAJ3710893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCH4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="426" mass="48239" checksum="E1748B21D7CAA299" modified="2024-01-24" version="1">MARIWGDLYVSECYVKRESSPNEDFYKRQKARWDAVDLPWGHHAGIHALPFRNLRYIHIHWSVFSWTPPSLSSEGDDVPISMSPNHWPGFQLAMLIKSNADTLDYVSIDEYPGFRLDQYTSTSNADGLLDLLAQNAPKLRSLSLGGLLRQFNPHIHITQPSDSSFFLSKDPPIYPSGEEVPNVSSDWACPNDDHLLTNPRQSSLESLSIRGFDSESTLLIEDAFLNRGVFSVTTIKYLALSAMPKDYNYMFLFSKLYQSLSHLTLDLDNSTLNLNLKFSLFPNLECVQLIVHTLYRARINLCNMVRSLSDNVFHLDGSIAAFHMVRLLHIALGPGVHPAIARQYLTAASIDEFLLNLVQHPPLGLSKSMGWTKLNMVTVDVSETILAKALPMTFATGCLKFVPHCYQPNFILVRDPRYIHAMQQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCQ0</accession>
    <name>A0AA38JCQ0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1021692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCQ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="952" mass="103312" checksum="1B4DF649F42314BF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCY3</accession>
    <name>A0AA38JCY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_508174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCY3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="243" mass="27993" checksum="E40EC8A4DC59FA4C" modified="2024-01-24" version="1">MASTSCLAIVQGKQKPVLCAVFRVYGGRIQSFGSAPAVSLRSQQVEAPWMTASQVAAGGNTKHLYQDANRTELIMEKFEDVFVPINSLIVMHRMNWKKRQLVDEQSNEKRTLPAKTLGDYVNIHHNHHGMNYFNTLQPLFLFAMYRYLVRHFDYKFSLKKLRESKSTVHWITIAACFPPMAIAFSFGHLLPLFGSKQRAYYSRYRNQTNLYYRLLNQLRSPLTISHPGIPTVVSSSYHTRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD96</accession>
    <name>A0AA38JD96_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1093789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD96"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3722062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57943" checksum="1A7AFACE60ABEAB8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDR7</accession>
    <name>A0AA38JDR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1044407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000122">
        <property type="protein sequence ID" value="KAJ3711250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDR7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="198" mass="22551" checksum="84A28A698780DFCA" modified="2024-01-24" version="1">MSARRPTLKLRALYALRRARATSLADGPGYLYAFVDCSRYWKLGMTSDFDRRKAQWDNECPCAHRRWLPPIRVTRRRRAGPNDIVLIVDELILKSLYFAVIGTGRGESSFDHSFCGLQYRCFSNHIMLTPPTCPDIPTLTTILTSKCLDLSDVQTFGCLDLNDVSTSVMSRHLDVSMSGTHILTENILKNLMGFMRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDU4</accession>
    <name>A0AA38JDU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor iws1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1103547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="214"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3714601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="405" mass="45511" checksum="68BC29CBA8900A15" modified="2024-01-24" version="1">MSTDKLARDIFGGSDSELSSDEDEVQDRQLDTGATAYDDEDDGVSDSEDDYQEKQPSASASRKKKSMKAGKLKQRSADGGEEEENGNGMRKRKRMSSGTKKTKKKSAYEDIDLSELPPEQANKIKLDMQLEAILKNKKSSRPKKRKNNDEVLDSFADDEVARLRETMNNAADEDIKAKEIKLPATAKLRFLSEAMETLRKASLAQSITDNNLLDAVRRWLEPLPDRSLPALNIQRELFAALRKMEFIDSAVIKEARLGPLVLFYTKCQRVQPDVRRVANELVSTWSRPIIKRSASYRDRVVPTVNSMDIDDAMGGMSGLQSQMQSQSQYRPEKLNAILARAREEDKKRIRKNAVSIPQSSIGTYTVAPRNNAGLAKVNASVDNDVERRKKNAERLRSLTRKVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JED7</accession>
    <name>A0AA38JED7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1091462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JED7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="749"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3724176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="839" mass="94134" checksum="FB5992D7632A45C9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF37</accession>
    <name>A0AA38JF37_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_416002</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF37"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="35"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3731509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="739" mass="81901" checksum="6676106A810A4CBF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF73</accession>
    <name>A0AA38JF73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1155288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF73"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="370" mass="40190" checksum="FCD203D1957A5194" modified="2024-01-24" version="1">MSSPKPNETSAHPKTPAHDSHATHQPYVSAQPYGYFFPPPGLPHPQQQVGHPIMPGGPGSGALLNHFGSTTPAPVHGQPMDPKSVPTHPHPRLLPRINCADFILPDEFSSPFNTHTPSYRAPPVPPPLSPEIASVGGGGNDSTKAKTKKVDKKVVVKPKATVKDDNNNDSNDDDKPGPKRGRTKGSSQYTDKEHTEITLVDACAAGSAIKKKVALGDLQDEDIEDINVDDEEDNNKVLTITSDSDEDTNKKAAKKKGKKPAVGTILTKAYKTKVPLWPTSRKTQSTNFLEKISLTLDPAAMQQRDENRLSANFQLLMLQSYQSQITTLTTQVNEERRRADDAESELRMLPTPHVQAVLLYAMNGGVSATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFE3</accession>
    <name>A0AA38JFE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1052957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFE3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37919" checksum="57A65A7359744BA3" modified="2024-01-24" version="1">MERVRKPKRSFSLKGEDSNLSTLSFFSTLTINADTPEFSFRLDLKRSESFPAHRFSCKGYWFHSDERYTAFPVPKDSAHLQLQLGESLGAGRTGTAYSAQVSAPLPQLSRPVPSELVVKFAKLNHCRNLAREAWIYNYLDRIPQSSGTIIPRCYGFFTTTLTELPSAKRPYDLPWSSVDGEHAKRDDDLWDDVEVEESLDEIPSELITKERSAWNSWVPDSKNPLVAVLILEKGGPMYNEIDDEDPLVKKDIKQIIRDLSLCGVAHGDFRMSNLVRSPTTTEVCPHHKCVHKWNIIDFNRAWVLDLGVECIPDAIVAVDPGYRQPGFYGWNPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFH8</accession>
    <name>A0AA38JFH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1087439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFH8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62898" checksum="1AA65263949790F8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFQ6</accession>
    <name>A0AA38JFQ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1000457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFQ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="188" mass="21617" checksum="6DEB16FE756D19D0" modified="2024-01-24" version="1" fragment="single">TVLPYSGNASAHPLWFQQAFTYLNVDLGEQYLSLLSSWIDKERIGAYENPKTGLEKKNRPATLSEWQKKRFVKSKDPNISDDNFIVSFSGEVWCWWVSLQPVWRAIAPGTKPSHPPVIKTGMTNWKSLDKKGLNGWFGILVCLKWWGMGLEHCPVEKREELKEDWLRAIDDVSAMLNGLLTYYRASPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG08</accession>
    <name>A0AA38JG08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_448951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG08"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="380" mass="42220" checksum="291BE6C28BEB9DB7" modified="2024-01-24" version="1">MYDAEFRLSLLERLSLIGVYIRLPFRLLVNVVLSPFLARTRGKRMNRVVAETVAGFLIANCSPRQLQYFLGPSIEKYVQWAKKNAIQPVIENVLGSNAKVVWLTDKRTDRVLFFVHGGGYMTPFVDNMVGYCPGLRKALLKETGGEQDFGIAALVYTIYPATFPTQLTEFTLALTQMITSGVSPENIILIGDSAGANLIIQLITHTVRPVPDIPPSPFVAIDDIDVPRRRLGGIILVSPWISLGTPAPSYAQNTKYDFLTAGPLTRWGSYYMNGVEPRHVPWVEPLSSSLYKGIEMLVSRVLITAGSRECLRDDAMNLFGMIKELQIPQEKLNITLDIEEGGIHEDAILDIESPQKPGGGLSQATMRQVHWIREAFEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGA6</accession>
    <name>A0AA38JGA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1085560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGA6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="462"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="630" mass="67160" checksum="E554EBE2EB11CFB6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH01</accession>
    <name>A0AA38JH01_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1076475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH01"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="685" mass="73447" checksum="9B8B93A777AD3969" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHS9</accession>
    <name>A0AA38JHS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_865419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHS9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041200312" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23589" checksum="F78B8FDE6FF89804" modified="2024-01-24" version="1">MHMKNFLLLLLAVIVHGPLDSTCIVFDVSSRIIDNTKLMVNYTLGNKDPPKWIVLVNADHFSVLFPIQMYGESQSDNGTLTFYRLNFDLNITLQGFGWNNSDIVPLGNETNPFLLPALVQVNNTATAFPETTTTSTSSRASSSSTSSSTPRSQTLSNNTKTHTIIIIGAAVGSFAFALILVVASFLWLRRRRQRKFAPSDFIRNKMIRELDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI00</accession>
    <name>A0AA38JI00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1091121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI00"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="331" mass="35486" checksum="E749932F7917AEF0" modified="2024-01-24" version="1">MSFVFYPTPTSKKTDFPRIDLEMVAVTRAQAKRAAALTSTAITSPVIINSPPSIGKHSVRKHAAISRSKQSKPGSSQGHPKQGGLASKRKPVRRPATPMFTDGESSMESIVHPKTPAESAVNHFISPESLLSSLELLENSVTAGPSGSKTGWIRFGNSLRRETVLPAGVMSQIQAQQQAALAQRADEAYEEQTKATMQQHNLTYQWYDRMMTEGLQNGQGPNAPLMLMGGTSNDTVMKDECGSDSHVNGDTDMEDCSAGGPCSSETNHTGEGSQSSSSSSQETMSSTGSNSSSNNVSIRSIPQMMGKQLQPCPPGVRYSLFSTPTEIIPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIG5</accession>
    <name>A0AA38JIG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1131228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIG5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20991" checksum="6419B6BAA8D413CE" modified="2024-01-24" version="1">MHLNIKWGKERVLKNFISEWSHLPLESIKLIHSGAVLKDENAPLSSFRLRPNATIQVVGSADNISPPSHGGPTQKSETSTISQIQEQLTSIRSSLVPSLEKFLQTLHISSNPQPTTTVPPDSSTQFPPIQKEYARLSEMLLQSLLTLDAITVDREWEQARQERKIAVKEVQGYLDQLDDTWNSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JII5</accession>
    <name>A0AA38JII5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1024528</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JII5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3732897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="360" mass="40269" checksum="B84FD4CF8CC1AE58" modified="2024-01-24" version="1">MNRDVSPVFDSLDVDLVFKVLKHTLFSPFFIFFIPIYYISSGGRMTDPFVIGSGSYYVLLCLYWLGDWLSTLYRNQGSLLYRPPRYDWGEQIVVVTGGASGVGELLANTLAVRNVTVVVLDVNPIVSENHNIVYYKCNISKWEEVEAASKKIVEEIGHPTVLVNNAGVVQGKLITDLGAADVQQTFGVNTLAHFWTLKAFLPNMIKNNSGHIVTISSNLAYTGVAQAADYCASKAAVNSLHDSLRQELDHQHKAPSVRTTLVCPGHLLTPLFASVSYPQSGWHKFFFPSVAPIDVVKSIIQALDDQHSKTIMLPLYSHLLPYRQHLPSYLKDFAQWLSGADYMLRNFRKVSGRRPDEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIR0</accession>
    <name>A0AA38JIR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1040179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIR0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="140" mass="15898" checksum="0DAA9E216ABB529A" modified="2024-01-24" version="1">MSARCSTRSFRDAYEPEKKRKERDVSKIRKKFDASGVGLCLPERLGLSKYLLLFSNCTSQLLISLLLPLRRPSGSVRALTDAGKSLIFWAKGKQSSKIVVDVESSMYAHNEDYKEDIRQANRTLIGISSQKAKLICWQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIS9</accession>
    <name>A0AA38JIS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1076913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3732013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIS9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="398" mass="43959" checksum="17382B7224CC227B" modified="2024-01-24" version="1">MQVYRTSLARCIASPHVRFNSTDVAKSNIQRLAASWDDIHIPSRKEVKQAQKTGSLSSRLAARRPHPSPASTTVTSPSPTPDAPVSPKMVPVASGQETIAPHKNSSQRRVHASPTSVKKPDVTLQSAADTLNDLFQDLPNLVSPVQNSWEKGLEAMNQNTKSSPKAKKVKVDGRSWTPEGGSKIAGRVATTAVTRNAGASARKENDKRSSRTIEDFDNMNEENSTTDQIVEDDEDAETYLDDTVIDGVSLLAPRPGQSTQLWYESILQQNREPEGARVIYPDIDISPDLHGLFGVGRAEQRSIMVSNLGALRRDRPAATKGKVEYQVRKVMRRYGGDYSHLQPSLVPTDLRRKMRPSQLARLNMSRRNEASAEQRKTFDSLISSTLRDTDTVEQAIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJE7</accession>
    <name>A0AA38JJE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1152640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJE7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3733939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="83" mass="9360" checksum="B8731136398C8656" modified="2024-01-24" version="1">MPTLDLKTNVSLPDVNKYMLELSKTAAETLGKPEKYINITVSSQPMTFQGTLDPAFQCTVSLNKTLFEHFERTLGVKDDRGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK20</accession>
    <name>A0AA38JK20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_996748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="258"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="455" mass="48472" checksum="FC0F7A46209FA4B1" modified="2024-01-24" version="1">MSHSPEPTKAAEKETSSRAVSETEASTPSNNEVKESPANPPVMDFPEGGFAGWATVLGAFLVQFCGFGYSASFGVYQAYYTTVYISNESASTVSWIGGVNASMSIFIGLISGRLFDKGYFYHMVWGGAVLDIVCLWLLCLAKPDSFYQNFLAQGLGCGIAQGMMYLPCIAVVSHYFRQRRALAMTIVASGSSMGSIIQPIMLNNLLNTNGFKTAAVANAALLSGILVIACALMRTRLPPPPTLMPFKTAIIKFSKDGAYVMGCLGLIIFSIGYYYPLFYIQLDAEKHGLSSHINFYVLVILNVFSFLGRLSPGFLANKVGVPNLITMGMFGCSVVMLGMIGAKSVGSFIVIAILYGYCAGTFISLANPLLAGFATDQMEVGARMGIGFTLSGIGALVGGSIEGALLTSEYVWWKPAVFSGVFALAGVALMVIMLIMIHQRKKAKAAAATNASEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKK6</accession>
    <name>A0AA38JKK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1070696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKK6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="40"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="225" mass="25382" checksum="A9E87F7A98EEE3F2" modified="2024-01-24" version="1">MSQIQLSASNNTDASLIYNYHRLHHQLSSASAIFCLCSLDKRVAVRAADLYLSGLAPLLIFSGGEGSLTERRFDGIPEAEVFAAIARNMGVPDEAMVVESRSTNTGENVRFTYMLLEEKGLLGEIESFILVQKPYMERRTYATFVKQWPGTEKNVKFSVTSPVLEWDQYPNEENPRELVINVMVGDLVRLREYPAKGFQIPQEIPPEVWAAAERLINAGYREHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKX5</accession>
    <name>A0AA38JKX5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_323794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKX5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="118" mass="13382" checksum="3AD1C8F221A31876" modified="2024-01-24" version="1">MHSMFDVQVVCMDNVSNSYVQEIQGDWIINCIKHMMSNDLTYIDAQEEAEQEWRKQVLSLGSMSLANKAETSWYYGSNIPGKVVEPYMFMGGVQNYDKTITEVASQGYVGFDLCSNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKY6</accession>
    <name>A0AA38JKY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TFIID-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_994314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKY6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="312" mass="34094" checksum="5DBB4C7FA71B026C" modified="2024-01-24" version="1">MSFALPARQVTFGRSNVPSQQQQLYQQQQIQQQVQQQQKQQQQAQQSGGLALPGGAYLQKPSNSAGPSPLSNSFQPSLQASHPQISPILSQSQTPPSTVGSPSNAVAGPSTPSAVPATPAPLTLEQQHITAVEGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVVTGAKSEDDSRLASRKYARIVQKLGFDAKFSEFKIQNIVGSCDVKFPIRLEGLAYSHGQFSSYEPELFPGLIYRMIKPKVVLLIFVSGKIVLTGAKVREEIYTAFNTIYTVLCEFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNG1</accession>
    <name>A0AA38JNG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_143228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNG1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="349" mass="38864" checksum="B5DBDC5A20599D19" modified="2024-01-24" version="1">MRYYEQKYPEVDELVMVQVRQIAEMGAYVKLLEYDNTEGMILLSELSRRRIRSVQKLIRVGRNEVVVVLRVDKEKGYIDLSKRRVSPEDIAKCEERYMKSKTVASILRHVASKIPSSDAEPRAVESAPTPVDAGDKDSKKARRAARQAAHDEDGVDDLPVATGNEEERLEMLYEQIAWPLGKIYGHPHDAFKLTLAEPDTVFGALQTTISPAIKSLLMTTIARRLTPQPIKLRADIEVTCYTPAGIDAIKKALRAGENESTEAVPIKVKLVAPPFYVLSTNATDKYSAVDRLERAIESIQSTIEDQGGSLVVKMKPKAVSETDEHDLAQLMAKAGQENAEVSGDEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNJ4</accession>
    <name>A0AA38JNJ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1039132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNJ4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Non-canonical E2 ubiquitin-conjugating enzyme C-terminal" evidence="1">
        <location>
            <begin position="127"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="393" mass="43739" checksum="9F62F05E2896862F" modified="2024-01-24" version="1">MSLESRKTLRKTLPDGSPDDFASPAYFSTNLPTRIRVELTFTRRTAIRQYTFPAGTSQPRTVVDITNDGPRTTMQFIQGGSNGDPILREFFVKYSEQAVALNLINAANARDLLGSAVASLRRPYSSVHTEYFHPTQTKDPKNSLAIPGGKGGARLSHEYAYVIQSSTLWKEILHDMFHLWSLAAEHLLSDSISYRLRDTTQGLNRVQPSSKTSRLMHAILHKAQKSVSSWVGSSVIHMGGHNVPNALLFIDKYTQIYRILLPICNTLSQIPNFVMAGMDKGAGMIYPDMAISPRNLQPVLTYAVEPSFNSISVDGDKSTKIRFYFWLTALQQKKMPSKRELADFTVDLAELVIRDGQGATKFVIATVKGAPTYEDIHHVAFRISTSALVKTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPQ7</accession>
    <name>A0AA38JPQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1152575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPQ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="331" mass="37649" checksum="E552B38EB7E2D10D" modified="2024-01-24" version="1">MPNAADTSIHWKKCKRTSIEDRLNQTAAARHVLNITAHTLPSPHLPSASLEEEHLSDKAAVEKYNDLHASTVDHGSAEEEEEREVTVWQDLQDYNSEGYDSEEEYYASCRGGFSLVWTVWHMFLQKLSSLYRLLLVHLALAVALFNLMVVASPLGTTHLLKRDPETSEFVIKLGRKQTGSDAWLPNSVDFAKDQKLILLIGNHLLEFQASNDPHIIHQNQIPLPDRSHCILLGGGRHSHLSLTIRSDKAAVFWAQITNLSDLEAKVGWKIHDDLDYNYAVLSVLIHGWGDPEWERMRFNEVKEWSEIISVNRDLRNNIRVPTESLSAKPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPS6</accession>
    <name>A0AA38JPS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1115862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPS6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="38"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="521" mass="56703" checksum="BAF0FB7223EF4D40" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPX5</accession>
    <name>A0AA38JPX5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1067354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPX5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="92"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="343"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="943"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1133" mass="126235" checksum="D167A049D8884531" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ38</accession>
    <name>A0AA38JQ38_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_73496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ38"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="205" mass="23122" checksum="305B93730B58F858" modified="2024-01-24" version="1">MSFGSDPQDFVQYALSLPDNISDDSSQESESFEPYTDSNSEIDSDASDMESNASNDALDTSEVISWDEIIRRADPRYRHRFLRHMMDYYTNPDPDVGPFDYSDSEFNYSHDSLVNSAHSSDSFHSAHSSIAESESGESSHNNGSESSTEPPDYMGPDGRLLESERERRRNLSLCFYCGGDHFRSHCPKLRAKYSGDSCYDHASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ48</accession>
    <name>A0AA38JQ48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1166844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ48"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="339" mass="38647" checksum="324AC0C561A91843" modified="2024-01-24" version="1">MAPFPVYPVDTGSVSSYFSSFPVRSCEFSALPTIQKALDETIYSCTTPGSRERKKAVYRHSNPAGNIFGLSLALCEADRISYVVKLIEFLCIVDDAMEDLPFEEACIEHSILRQALHESYDDDRYGGQAVDLMKNFLRELRKELVSLGDLSTSLLLKTLDTSLRDRDSDDSEFTTLAEYIPYRKTNFDYDFVCQLLCWAMNIPLAVQNDPLARAYEHIIGVIVGLSNDYFSWEMERQQTTDRVRNAVPVLMKEHSVSEVQAKLMLKEVIVEEERKARKLKSDITSQSVKDEDLARYVSGMELFAAGYSFWCATCPRYHRPQKEENPVELNAEFSIAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQE0</accession>
    <name>A0AA38JQE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1068132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQE0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="188" mass="21116" checksum="298F6F96A6D518A9" modified="2024-01-24" version="1">MLDSLNELGSAGGPGKLEKQVMALFTSSIHHYVTPKFYTATKPDTGKVVPTWNYAAVQVYGEASIYYRTDDEKTSEFLNRQISDLSNAGEQQVMEIMRSDREKDDERWKEPWKVSDAPPRYVELLKKAIIGIEIKIQSIDGKFKMSQEMSKGDREGVVAGFMSMGNEVANKLADVVKHRGELADAKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR79</accession>
    <name>A0AA38JR79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1149050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR79"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="318" mass="35290" checksum="D92BBB041353DFF1" modified="2024-01-24" version="1">MASSSKPIEILFKHVDGIDIYMDVYLSPSSSQQSPAPILLWWHGGGLLQGTRKGVSPHHLRAPASHGVTFISADYRLAPQFRLPTILSDCADAVKFLHTQQFQKATEGRADASRVILSGSSAGGWLSLLCGYRIGFDEIGVPKPPSVQGVVPIYPITDLEDPFWTTTQRPVKYMDRVIAREEVQPFLNPDEPTSRIASSALDSPRAIFYSFMVQEALLADLLLSGTEIPPSAFSIAGSLKTRKLDCPPTYIVHGDQDLKVPVKQSRDVVQALEELKQKGNADCEYEYEELPGLDHLFDREPKSQMEKMYAFIVRVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR86</accession>
    <name>A0AA38JR86_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_987971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR86"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="490" mass="55413" checksum="AFA5B57C188EA0D3" modified="2024-01-24" version="1">MPRRHHTTASKANESAWKGYAEFLEGQTEATKARLRAIANPGLSALRQSPVSIDLRHKLAEACPEKAHNLPPLQEIFHDFFQFAGRHGAEYPRVAEALALRKEAVTNYRFTKKDLAATLVGDAAEGQGRRDRILSAETIEVEKQSEPYPEVGWYIAESGDIYKTWDNWLRERKMPDSRVKRRLCKKLDESKLQVNLPADKSAIFIDASTKKLVGYVFRDWCGDAELVHQVNEIVVDAVEKSISKEDTGGLVLAGWSAGARSTGLFDWCNNLRKKNQSEDSAFALRLRQSSAFAIMWNMCLSGLPDEVLLDYEDWRRRSLIYPMDPAVKFGEEERVITVKYRGEDLKFHNATMAPPCGVFAVNYSRYIHVENQPHRWGTAWTTFRDPTKKGGSFFFSDYGIRVCPATDTLHGWEPARPHGTSLPNTGPDPRCKYPDVVQSGLSIVTSPRIEAAFRRFCESSGNVEVSALQEEFVSSVQEEEADEFLLEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRZ7</accession>
    <name>A0AA38JRZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_110435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRZ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041444697" description="MARVEL domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27280" checksum="AA2D32BA87A5A91F" modified="2024-01-24" version="1">MYLTSLLHCIRLMALMSSLPPPASAPSSFFTSRPATMVPTKRLPSRKSKFRPDSLPLPYYKPLTFKRRRIRRMSMSTNVTGHFHPFLFTMMTLCAAAELGLTAFLISAGNANGTWPSPRYHALLIMFAFNSSWTLLFSTAYMLYLFDGATHFLANVASSVIWILLTSILWGTAAGIMHNTRTGTDCPNVPTISRCRQSLTVEALGWTEFGLCTVNVLVTCAWVYCSHPKIHPRASFLGDSRRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS89</accession>
    <name>A0AA38JS89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_990557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS89"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="278" mass="31662" checksum="466C3B91DC1B65E6" modified="2024-01-24" version="1">MELLLKTDSRFVINILKNHRKLEDEGYISSPHPQLMRSTIASFRMRPTQTYMKWVRGHNGHERNEGADRLASEATKKEKASFVNLGLPRELNVTGAKLSTMTQALAYKAIMAMKAKDDDMYRRRTDINLMRIKNCVEDLFGYVPTSEAIWKSIRNKDFELKIQIFMWKACHYAFWTGTHWTIPGMKAELQERAICHSCDQIDDLNHILTKCESPGQALIWELAGKLWDKKSSNIQWREPTIGDILGCGLVLGACGSSGPSIPLLTVSSLRCAVRVKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTN2</accession>
    <name>A0AA38JTN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1048968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTN2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041416878" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="237" mass="26088" checksum="49CF5A8BA8B5D16F" modified="2024-01-24" version="1">MTLPTVICILFLGCLFLGSSAVDVKGQISWNDICRGYNQLGHARVVLDNMKYGGGVLRDGSFVIPNVPSGTYLLSVISHDHKFDQMRIDIKDSTSSGEFIEVRPYIPGTPMNPASTILLPYPITISARERFNYFVPRESFNIMGMLKSPMILMMIFAGGLVLGMPYLMKNMDPESLQEFKKEQAKMSHAQNALQSGDFKSGLSALMGAASGQDQTTSQPSQIRAQAANKNRGKGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTW2</accession>
    <name>A0AA38JTW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_987709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTW2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="225" mass="25048" checksum="152519A7933B26B8" modified="2024-01-24" version="1">MSHSASSSVSTPAASGSGSNQNLHPHLENNDEKNSVVMKVGMVGDSQIGKTSLMVKYVEGSFDEDYIQTLGVNFMEKTISVRRTTITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLSRKSTLNSVKEWYRQARGFNKTAIPFLIGTKFDQFATFPRDEQEEITKQAKRFARAMHASLIFCSTSASINVQKIFKIVLAKAFDLKCVIPEIEGVGEPVLIYVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU07</accession>
    <name>A0AA38JU07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1051352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="101" mass="11593" checksum="8EEA84539728EA22" modified="2024-01-24" version="1">MARSNLRVGLNKGHPTTPIPKTVRPSQRKGIQSTKTKFVRSVIREVAGFSAYERRVMELLRNSKDKKARKLTKKRLGTLLRSKRKLEELGTIIQESRRAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU75</accession>
    <name>A0AA38JU75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1131522</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="362"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3732938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="419" mass="46419" checksum="B34F49F0EA20DC3F" modified="2024-01-24" version="1">MITRRLQEVLGGEAIKAILQEGRTPKAYWGTAPTGRPHIGYFVPLTKIADFLRAGVEVKILLADVHAFLDNLKAPLELVEHRTKYYKYVLLAVFKSLGIPTSKLHLIQGSTYQLTREYNMDNYRLCATVTEHDAKKAGAEVVKQVESPLLSGLLYPGLQALDEQYLDVDFQFGGVDQRKIFTFAELYLPRLGYRKRSHLMNAMVPGLMGGKMSSSDPNSKIDFLDSPEVVKKKIKGAFCEPGNVEDNGLLAFAEAVLFPISQLKIDQAKGTGVIDEDGKEALSTDQKSFASDNAPEGTLFTVNTKFDGPMHFSTFAELRQVFKDEKLHPADLKPAMVDAINRLLDPIRKAFEASEDFQKTENLAYPDLNAKQPAKKKKEKVYHPPPPGKGKNAKPNDAPVEALTESEPPAASKTPNESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUG0</accession>
    <name>A0AA38JUG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1045723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUG0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="319" mass="34898" checksum="DA305912628B8E94" modified="2024-01-24" version="1">MTPQEQAQLSAAAELYYLDVINIISTGVGIGMFGIGFCVALWYLSNSRWGHAKIILLSCCLVIVLCSCWSLAYFGSYTLSSIRLVFVDQSIEIDLKTSIILDYINSWLPSIALVTGDFIVTWRAWVLLENNYYLQLILAVLGVANLGTNIASCIEDSIRVKSKLIGTISVLDWLSNACSIALNLCATSLIAWKAWTHNHTVKGSLHQKKTYVQKVLLLLIESGAWFCSIQLTVLAFTLVSIYVSNAGSLGFQEAFAVISAASTLAPAWYPVAVIILIQSNNSPVVETLHNTHSGRHLSDVDGNVEEASSNVEQGGRLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWU0</accession>
    <name>A0AA38JWU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1149517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWU0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="179"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3737045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="555" mass="59640" checksum="C177A51FCBF45F79" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQI4</accession>
    <name>A0AA38MQI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_961013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000116">
        <property type="protein sequence ID" value="KAJ3711653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQI4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="2">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="113" mass="12879" checksum="7EE6769F2C5F617C" modified="2024-01-24" version="1" fragment="single">SSADQDRRFSEKELKLLKSMKFPPEFDKKVGKLDSVDMRKVNLTVIRPWIAKKVVEIVGFEDEAVVEYAMGLLEDKQEPTPDPKKMQIILTGILAEDTPAFMSALWNLLLEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRF8</accession>
    <name>A0AA38MRF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1134225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRF8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09245">
        <property type="entry name" value="BRO1_UmRIM23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3719015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="449" mass="49460" checksum="C5308125E2C0A4E1" modified="2024-01-24" version="1">MTTFLYDLSTTGAISFSDFINDPDNSFTRRLSEITQLRSRLRGFLKESKRTDGEKDYLTIIKIIDDYLPHLQGVMNCVNDHELELKFEPVFSWRTTLSANFLNNSPRMALQSLNAEHASSLLTYAFAHSNLARAIVASLGPYEHDRAISQAEREAKEEQLKHATNHLSRASGIFTYLSETVLSELQQSASVSKFKLPPDLLPEVNTALSRMTLADAQTLAIRKLLSKSFYDGNIAPGPPLPKSHPAPGLIAKLHLECVSLYSTARTLAKTPSASSKSSEDVSPELRHYLADETSLNSALAKKWLGIDAGENGGQKRGGEAVGFLIWAKKELQDIKDGGKGAALAKGEKEKRDRNLRKEKVAIELETIDSWLKHYQKVNDTIHFQPVPSQAELQSRIPTGVSAVFSIPYVPQKPAFGPGSDARSQKEQATLDQGDSMSGSSTYAGAGEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSU8</accession>
    <name>A0AA38MSU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_468379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSU8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3730141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="347" mass="38012" checksum="DBAB67003B835434" modified="2024-01-24" version="1">MSQQAIIVTGASGYVGSYITYQLLEDGYKVKGVARGEKVSFLRNAFAKYPAFEAVEIMDISSGDFSFMRGMDAVIHCAAPMIIEKADHEAALKGAVDGSLHVLQQAKDAGIKKVVVTGSLASFPRFGPYGPDDFHPVTLEEAKSCGNPNLIYTAEKKFADMAILDFADKHPEMDVTIISPTLIIGPLAPGFSHLVPTVNFRAFSSAFYLYSILNGSNPQFPMADSFIDIRDVARAHILALNSPPSSSVGRKRFALKHPDQSNFRQAIELLTAERPLLKERLPPLLSAPVWPENKGKMIDFNNLESILGLKKEVFMSWRDTVLDGVDSYVAVENSWKAKGLEVVSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUE3</accession>
    <name>A0AA38MUE3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1153994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUE3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="161" mass="18098" checksum="4186D06D9D0EAD51" modified="2024-01-24" version="1">MEEQADLVSEATDQLRKTVTVKIWIKNGSTPIILPTYTPTYPLFKIEFCLPFLHHILQGNTSALVATYDPISTQWQYHNTATVRQVYRNGITLYCLLPSGLEGGHIIDCPGLDDDISAYNPHQQPLTTSMPQSWPTDYLFGKVVPGLQQLKQSHPSKNIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUH9</accession>
    <name>A0AA38MUH9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1169114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000123">
        <property type="protein sequence ID" value="KAJ3711117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUH9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="167" mass="18602" checksum="EE0692AAD90A84CF" modified="2024-01-24" version="1">MAFASRVTTNDSAYREYKSLNAIVVPLSTYFSILMTHAEAAGRVSAIGTDFFKYNAHLIKVTSEYDWSAVVGYHMAFFNKRRCEMQSGDYSGWGKVDMELRGEYLYNAPQLSPSSSSRSSKKPPSGKSEACRKFEQGLCSSTPCPFGRPHICKKCKSAMTDTSHKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUJ2</accession>
    <name>A0AA38MUJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1107692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000119">
        <property type="protein sequence ID" value="KAJ3711440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59335" checksum="3F00FDB38AEC2743" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUV6</accession>
    <name>A0AA38MUV6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1044450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000126">
        <property type="protein sequence ID" value="KAJ3711071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUV6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="139" mass="15098" checksum="EAAA9E79ED8172F3" modified="2024-01-24" version="1" fragment="single">PFGWRVGSGAGPAEFANAHVGIEATTYEGLDILFNHAWNNMALVETARPFVPDIVEEIAKTGKLCGKVGFLGVNSFDCKNYVATIHRDNDKAPTITAQLRLNGTNLARSLLTQMSTMGPCSQPKQLLTWPGLAKQRVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVP5</accession>
    <name>A0AA38MVP5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1160611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000087">
        <property type="protein sequence ID" value="KAJ3714948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVP5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3714948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="295" mass="30822" checksum="FAA80A84A842EB3D" modified="2024-01-24" version="1">MSPIDSEALVQHLIAQTRSNISFLISQHQISPTSGREILDRLPNVGVSIPDPVTALSEQASNFQISGPSTPPPASYGSRDHPATASVKAKAVWGYNETGEDPQDLSFRAGDIIEVVQETNNDWWTGSYNGREGLFPSTYVEKLPPSSPLSRPPPSPAARNNPIYKSNPNNTFHGSSYSDTTPLGPPAAPNPTYLTSYAPTGPPPRGPSPSRYGPPPSGYYQSPPPPQAYNSFPYPPGPPPPGPVVVSASAPPAPLDQPKKSKFGGMGNTLATAAVGGLGFGAGSAIGADVVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVT6</accession>
    <name>A0AA38MVT6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1101994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVT6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3715565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="313" mass="34661" checksum="D2BE181183A87278" modified="2024-01-24" version="1">MSQGTAKLTDFKVLVFDVYGTLANWETGIYLGLEPMLSRYTESSSWSRKQALEAYTAVESDLQAKYPHLLYSDLLSKVHQVMEERLKAASGLPAASSAESDSSSPADNSGASTSNQSAPALLDDEHVQFGQSIKDWPIFPDSSAALHTLSKYYKLVVLSNVDRRSFAHTLAKLSEGPSTEFAPETYLPPDSKDLWYPQHSSKSKSPFTLVLTAQDVQSYKPALRGFEIALDIIHQESELLNTPKHQVLWVAQSLFHDIEPVGRLGVNSAFIDRKGATMGFRAGLQPPYSWKFETLGEMAEAVMKESIQYGETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVU7</accession>
    <name>A0AA38MVU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Retrograde transport protein Dsl1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1059790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVU7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="2">
        <location>
            <begin position="679"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="813"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="105964" checksum="960EC934CF3B565C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW28</accession>
    <name>A0AA38MW28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA breaking-rejoining enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1227053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW28"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF4">
        <property type="entry name" value="DNA ADENINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3719653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119445" checksum="AE5C51BA596315A0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWC0</accession>
    <name>A0AA38MWC0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1101048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWC0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3716319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="420" mass="46171" checksum="B78DBA2BB003CCAF" modified="2024-01-24" version="1">MKLIGKYVDKHGAGHVTLRPEDDEDMWHLYNLIQKGDSVRAPAIRRVQKTSTTGSIDSQRIRLNLTLAVTSVEFSSYSAAAEQSSSADPSGSNNSAALQIAGRVIVENPHVKLGAFHTLDIEANRDVRIEKSDGWDSIALSRVEEAIVPGRGAEVGAIVCGEGTAAFCLLSEHMTLVTHRISVPIPRKAASAGSSQHDKALTKFYSTLYDAFIRHIPFGNVGLKAIVFASPGWVRDSVYEYVMQEAGKRNDKVLQRALREKGIKIHISSPHVHSLVEVLKSPEISAQLKETKFAREGLALDKFHKMLATDELRAWYGPKHVALAADRGAIGTLLISDELFRASDPDTRKKYVALVEGVQQKGGDAVIFSSMHESGQQLNQLSGIAAILTFPLDIEVVEAEEKEEEQRKKREMEVDEKEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWH3</accession>
    <name>A0AA38MWH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_752132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWH3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="200" mass="23252" checksum="4B528CD0E179E521" modified="2024-01-24" version="1">MFRNSSLRTRNFLSSSTSSLIVYISTSLRYIDALPLNCNLFRGQLSSSVIPLPSLGLYGFHPSIALCALPINNNKCVIILHIWYLTEPLCILVRFLLVMKLEWVENYNYWLFSRLTLIMDSIRRPKASQRTARKFLENDNHLLYDKNAKSFIGTVNQHSTRRPNGIYRMRITPEKGKSVLDTWTRTLSAHRRLVVLPPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWX1</accession>
    <name>A0AA38MWX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1032480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWX1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="648"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3718037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="791" mass="90165" checksum="930C891834025F73" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX13</accession>
    <name>A0AA38MX13_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0052-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1094173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX13"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3721399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="489" mass="53371" checksum="84E962780A470484" modified="2024-01-24" version="1">MMDSQTANSSSSLSIQPDGIDSPGSSVFDLPIQNPAPARNTSHFEIRPEELTNLRAHDHEPASVDSDSFVFISGGTGGNTICTAFPNACYVLPVSDDGGSSSEIIRVLGGPSVGDIRSRLVRLIPIASPSSPLNAIKTLLAYRLPHHYSERQAREEWRDIVEGRSALWNGIPTDRKETIRGFLVYFESEVLKRAHKNFIFVNGSIGNYFIAAAQGFFRSLPSAIFLFSSITNSQANILPVIVTNHTVTIAAELENGERIVGQCDISHPVTVLQAPTINVVNAWSPLDGLESPATNVLFEAEDKDRYEPLSSRISRLLYINAYGIEIHPSPNPDYILSLKANNVLVYSCGSLWTSIMPCLALQGVARAIARSSSLRAKILLLNSENDRETDGYSAVDYIQAIAHTLNTQYQIQPYGLGNAQTMYPISAFITDLVYLKGGAVAVDSDKITALGVRCTEVVSELDDGGNHRLPRFSANTVRRAVNEILTRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX63</accession>
    <name>A0AA38MX63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_989992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX63"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="344" mass="37372" checksum="F0D0FE74B3A26934" modified="2024-01-24" version="1">MSVSLSEFNGHIAQGTTFRGSSNGRIVKSFFQRSLGPDEVAVQVTHSGVCGTDLHYMLQDMVLGHEAVGIVSAVGSACTLFKPGDRVGWGYEHYSCGFCTPCLTNEECHCLNAGFYGASDFDQGSFSNIGVWKQKWLFHIPEGIKSEDAAPLMCGGASCFSPLIEHCRPIDRVGIVGMGGLGHLAIQFAAKMGCEVVVFSGSESKRTDALALGASAFYNIQDVSDFSTLGITKPIDRLIVAAASLMDVSQFYPVLARKAIIIPLTATKETLAVPYYDTLFTGVKIIPSMLATRFTQTKMLEFADRHHIRPIIEKFPMTEAGIGAAIEKLKNGQIRYRAVLSWDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXE0</accession>
    <name>A0AA38MXE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1031767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXE0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="615" mass="68162" checksum="2A7476FC58D5ACE6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXU9</accession>
    <name>A0AA38MXU9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_677208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXU9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="53754" checksum="3CE7DF070AC57C77" modified="2024-01-24" version="1">MGLHIPSLLSRPGPRHSFDRLRSFHLTPSPGTVTPTPAYDTTQATVGGTLSNIPVFKETSLSVQTSRPSPVRAVNGIIPVPPIFYFGLAILCSVIFVLTIPSVFHGVTTQESVFKGILDEVAQTNPGIVLLGENVDIDVDEPSVTIRWSIVACGQEYMLPDSSGVHGSSMCGLPNFPLQVYVDGDDDPAGTFNPELIPYTDKGKRRRIQNLVQFDSDLVLDVHNDRLYPFDTYFLSSTLRATSDQNYTVPFTKLATVDLTSSFVVETVDVQSYVISADGVNEPSRDIDMYIRRPIEARLITLSLFASSWFLTHICIGNVILARRTIDVKPLLKLLIVNGLTLIGLPQIRNSMPDAPGLDGVLIDAIGFFPQMIIVGFSVVILLLTVIARELNHREKSALPRHASITPLPKLGGPSRQSGVKHRPPPLPLPTSTSTEIAKYNIHRITQHLKGEFVFPPVDIGGMRSIPEEAGSPRSPAHKRFKTATGSPQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYS8</accession>
    <name>A0AA38MYS8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1045963</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYS8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3737729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="556" mass="60555" checksum="E25ECA1375514062" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0E0</accession>
    <name>A0AA38N0E0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1071700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0E0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3732855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="408" mass="45289" checksum="A8447A8F536FA933" modified="2024-01-24" version="1">MAEENAKSPSLSPREPSEPVSEPVSVQVESPQASVAAGSSIEAATRSELISRARSFLSSPQIQSQDIFAKRRFLVDKGLNETEIELLLRELPPQLPRVPPRTYPQPPPSGLLTLLIGFAKIFTWIAGGSATLLFLYHRFLLPRILRTAESRKSLKIHQVSLLKKLNASLKSLKETQTQCYALLPRPDPHKEPSVFAGCHSLLDVLTEAETHKLEINELPHLTLLRCAWEDFRKLPDCADSNPRTEELFQVLESRIPWLVSAEGVPFERNLWEVLSTTSVFNGLTSQDSPGEVSAPVRWAYVPPKPAIPTPFLSSLESLSSTVTTYQPQSTSSPYQYTLQAMSEFTGYISSNLYTPYRPPPLPGTTAPSMGEPADELKKEIRALKGLVLNRRSFMPTIPRVSIPSSQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0E9</accession>
    <name>A0AA38N0E9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0E9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="281" mass="32559" checksum="1EFE0CE60BC8A190" modified="2024-01-24" version="1">MNNNAKASSSKRRPTDNGDDERKRPRKRMDNRRKERLARLRQKVRSRKAIVRKEEEKEQNGEENDEERRKKLSPIEEPPMPLASRSDFPPDHWVEPIEEDLRPLPQYPDHRVSVVIPPLPSSSPPAEGPVIGALRIPRCANCKIGARRRIKCADNETLAARNARLAKGEKSSKRRGKKEEEVEEDDEEDNEIVHLPKGPRLGHRERYPRGAQSLEDRILIENRRIGEQQEMTLRVLDRMEERQEKIENELARIARMLEARESEANEGSEGEGNEGKNDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N181</accession>
    <name>A0AA38N181_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1067465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N181"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3733516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="18325" checksum="B573285EEB36A185" modified="2024-01-24" version="1">MEAVMRVTDTIKSFRETRLAALRPPTEFFDYQRISRPSDFNQATQRITYNTRYFSGNYVLIISLLAVYALLSNPLLLIALGFLVGGFIAINKFGPEPMQMGEHTITQKHLYTALFVIGLPLLFIASPVMTFFWLVGASGVLILGHASFIEPGIESEYAAVQDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N209</accession>
    <name>A0AA38N209_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1062992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N209"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="713"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="790"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="912" mass="100263" checksum="09E5534135BFDD45" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3B9</accession>
    <name>A0AA38N3B9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_160974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3B9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041274515" evidence="5">
        <location>
            <begin position="26"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="474" mass="52334" checksum="30929F61265FA12B" modified="2024-01-24" version="1">MLHTPLSLLFLCQVIILSKRTVVEGKQQCRLQLNNIMTEPSIPTSVVPVSPNSSTPSSSSNSTSSAPTRTPFNYSEGTVRGVNLGGWFVLEPWITPSIFEATNDDTIVDEYTLGQKTTNYNDTLAMLQNHWNTWITEDDFIAISNAGLNHVRIPVGYWSVPLPSSATNTSTLVSPYIPGAWPYLLRALNWAAAHNIHVIFDLHGAPGSQNGYDNSGQRTSDPQWALNTQNVTRSIDTLVYVAQQIGGMIDVLELLNESAGFLSTEWANVTRSFFSNGYTAVRNAVGNSLNIMIGDAFLGVDAWDGFLTYPSGLNALMDNHEYQIFSIPELQRSFTEHLTFTCTTRSTISSFASANIWTIVGEWSTAPTDCALWLNGRGVGARWDNSYNGGPANGSCNGWTGNYTSFSNDYKTFLRQYWEAQVDIGESAQGWVYWAWKTESADEWSYQKGLEGGWIPADPTERMYSDPCSNSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N450</accession>
    <name>A0AA38N450_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1221540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N450"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1035" mass="111202" checksum="7F6187890D874BA0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4C8</accession>
    <name>A0AA38N4C8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_518892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4C8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041287159" evidence="1">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="205" mass="21716" checksum="FC27FBBDF8A3EAE1" modified="2024-01-24" version="1">MLLITSTFILLSVFLQAVTAQDWYTVEWDATEFVSMSGDMIVPDLPTPGGTPYVWPGVQSGDGVLQAVLDGSSGVWWIGDGFYGTPSLPWGNGFNVSPGETVHFTFTSSGTTWTCTLSSGSQSASTTLDITGNTMNRAIFAVELYDVDFNFGPITYKNIEITATTAASGWCGSIPHLGTYPYTVTGNVASGNTCTVSQIVQSSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4E4</accession>
    <name>A0AA38N4E4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_394506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4E4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000387">
        <property type="entry name" value="Polyubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="229"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="312" mass="34942" checksum="83454AE2C9696977" modified="2024-01-24" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLGKCCVSLNHFVGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4K9</accession>
    <name>A0AA38N4K9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1150378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4K9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3736083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="162" mass="18542" checksum="602186F733775DEE" modified="2024-01-24" version="1">MIVLKTSDNETFTVERDVAERSVLIKNMLDDIGENSEQAIPLPNVNSSVLKKVLEYCEHHRGEPLPAADADTSQDDTRKRTTDISEWDQKFITVDQEMLFEIILAANYLDIKSLLDVGCKTVANMIKGKTPEEIRKLFNIVNDFTPEEEAQIKKENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N512</accession>
    <name>A0AA38N512_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1049856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N512"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="179" mass="20047" checksum="F03736DCE57853D5" modified="2024-01-24" version="1">MGGIGSTGKRPTVFMHGRGPEEGEKWLEDIYNDNYAHHVTWQLPHRHGHLYWSILSSHKKCYCSNSLPPHPLLAEFIAQPPTSNSRLRPSISSSLSSSYQPYQLKVYPHGFAYLDEILVSALVYERKRTTPSFQTVHVAPARTKYERYPGGAPSNTPSNTHSNQTLSSLAAGSEAIHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N562</accession>
    <name>A0AA38N562_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_25391</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N562"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="170"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="32"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3737791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="338" mass="35185" checksum="FC407149D7D53799" modified="2024-01-24" version="1">MFARNTARALTAPSARLFSSSSARQTKVTVLGAGGGIGQPLSLLLKLDPLVSNLSLYDIRGAPGVAADVSHVDTHSEVNGYAMENLDDALEGTKVVVIPAGVPRKPGMTRDDLFNTNASIVRDLAAAVGRVAPTAHILVISNPVNSTVPIVAATLEKAGVFDPARLFGVTTLDVVRASRFLASVSGTTPSECDVPVVGGHSGPTIVPLLSQVSKGKGLQGESYDKLIHRIQFGGDEVVKAKDGAGSATLSMAYAGAKFTNSLLRGLNGEKGVITPTFVKSPLFADKGIDFFSSPVELGVNGVEKIHPIGHLSAEEEKLLEACLPELKKNIEKGKAFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1Y1</accession>
    <name>A0AA38J1Y1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1161270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000103">
        <property type="protein sequence ID" value="KAJ3712993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1Y1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="42"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3712993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="296" mass="33204" checksum="8F6063058CF3EDA7" modified="2024-01-24" version="1">MSSTHTDHITEGFIQFNIPSLPDKPCHTYYKVIGTLASDTTPLIALHGGPGVNHEYLNILADLRIPLVVYDQIGTGKSTHYPEKMGDTSFWIEQLFLDELDTVLHHLGLQDNYNLAGHSWGGMLAARHAALQPKGLRRLVLMSAPADMQLWIQSQNRLRKQLPQTVQDVMADHEANNTTESKEYQEAMGVFYAHFLCRLDPMPEPIVNGFAEVAKDPTVYLTMNGPSEFHITGPLANWSIVQDAHKITAPTLITNGQFDEAQDEVIAPFLKEIAHVKWVKFSNSVRLSYSKQQALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3K2</accession>
    <name>A0AA38J3K2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1099421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000073">
        <property type="protein sequence ID" value="KAJ3717587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3K2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041488109" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3717587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="651" mass="71401" checksum="736C7B34C2C575A3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4B9</accession>
    <name>A0AA38J4B9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_723227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4B9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3720256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="430" mass="48212" checksum="B47D562C7FA01963" modified="2024-01-24" version="1">MNSPTMANSTKKLRVAIIGGGIGGLTCAVALKDCPNIDLDLYEQAAQITEIGAGITVWPRTWVFLKSMGLEKDLLAILPEGYSDEPKLAFEFRISDRKDGFTFHKIYAKGGALCFHRQEIQRTLLKHIPKSYRIHLSHRMTRCEESGDCVKMFFEGGLEATCDVLIGADGIKSVTRKLFPNEGIFYTGSQVYRGLIPKESFAKSYPNHKALEGPIQYCGKNKHIVVYPISGGRIINVVAFFSNPDDEGKSLDGPEIRSATTEEALKMFSGWEDEVGQLLGSIEAPSRWVIRDLRPMETYVSRRIALVGDSCHTMTPHLGAGAGQAMEDGYVLGRLFSRESSQKWERILQAYNQVRHPFGNMVQRNAREQGFFYELNAPGFENITTMGQELSPEQVSLLRATITRNWSWWEDDADEDLARAIGFLSMYLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6J5</accession>
    <name>A0AA38J6J5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6J5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="122" mass="13387" checksum="FCA000A5646519F2" modified="2024-01-24" version="1">MIITDQEPTLIVKDEPSPSSAVIELLNDADNGDKNPILNQPIKLKLPCLRQYPRSNQPKIQGEAKARYPSPPPIAPPPLHDCAAHYQTWQASGQRPPTPKQKGQDESSDSEAEKTKAAEANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J745</accession>
    <name>A0AA38J745_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1133248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J745"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="246" mass="28142" checksum="D57EF4CA0E8EFEC6" modified="2024-01-24" version="1">MITLYDFAWKFGQGVCWNPHVGKLRYCLNYKGLQYKTIWIEYPDVKATIEKIGAKSTGLQPTGEPWYTIPAIVDDATGVALAESADIVEYLDNTYPNTPRLIPEGTHAFQAAFRDAFYPKLAYYYPFLVPITETVLNPPSATFFRAKYEAIFGKKLENVYPEGQERVVAWNKWKEAIGGVDAWMNKDDIWMMGNTPSFADFILASFILSAKTLFGADSQEYKEVLEMHDGRWGRLAKNVERYNRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7A8</accession>
    <name>A0AA38J7A8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_140519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000135">
        <property type="protein sequence ID" value="KAJ3710608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7A8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="307" mass="34791" checksum="C7E8477E7328457E" modified="2024-01-24" version="1">MSTGIRGLPCSPSIPLTGTEDPGECSFIDLATLTRRLEQVQHVPQQLSRYAQVEYNKFCVLNQDSFVASIFPNPHSRQLDPVCSNREIKQISGLAPYILHVPSLWPETTPARLQAGDQTVLPSHDGLSQRILFPHEISRRLLRLGPAPHHIFPHPSTHPVLSRYDEDQELFHTETSRKTSLSYYPSIPPKETRMRRIVDYQKIRCPIPSCTAVISPYIEDVRTHLVCDHCSLYSLRLKTSPSECLHCSCGHWIHGGGEAIALHIACSHVPGWKVECTYCDWEGLRETFERHLPLCSDLRSQMTDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7I5</accession>
    <name>A0AA38J7I5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cu-oxidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_468840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7I5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041414686" evidence="7">
        <location>
            <begin position="20"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="163"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="375"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3730134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="524" mass="56847" checksum="37B30BE92EC6FFDD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J837</accession>
    <name>A0AA38J837_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_553919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J837"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="305" mass="34172" checksum="BE82A4C3BA56B793" modified="2024-01-24" version="1">MSNISDCVSSEDETLFNRDITISLETLPYKCNAWSSIYRGHHKGRPVSVKVWRGEGLLSPSRERTEFLRNLEREVRVWQAMSHPNIGTVHGMLFAPSNLPSVVAPYYPNGDINTYVSNNICTNLKALLLGVAAGLQYLHQLNPPISHGDVRGCNIFITNNGVPVLTDIGLNFLPVPPDWTIPSGDGARWLAPEVMDPHSTKSSSKFDCHTTTMSDVYSFGMTMLEVYTGQVPFFHRRFYAGVVLDVLRGIRPRRPNAESSASLTDEIWCIIQSCWTQDPSQRPTMESITSWLRLMIRVESAACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8A1</accession>
    <name>A0AA38J8A1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal protein subunit L20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_443089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8A1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="189" mass="21454" checksum="E194507B28FAEB8A" modified="2024-01-24" version="1">MLGHRLASFTRPLTRAYAPKWPRPKPGTSERPPYRPSDPLNNNPSATVTALPDENLTFIHRPPPTAPSPISYTTNPVSPLLRPPTSPTSILPPLLRPSVDKSVPTRLTAVQVAEIRRLRSLDPVKWTRGRLAKKFDCTQQFVALVAATKKTTRTKLIRRRDEEHEANRGKWSEKRSLVAAISQKRRQYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8Q1</accession>
    <name>A0AA38J8Q1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1161539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000111">
        <property type="protein sequence ID" value="KAJ3712133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8Q1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3712133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="133" mass="14567" checksum="1299EC96FD445EAF" modified="2024-01-24" version="1">MGLGASNADWYIPEDTSAAIELFYKAENHGKLGQGGNPTKAALNECAAYLVKKLKIKGIFEATLVLEIWSSVDTGASVYQQSALVDSYPPYGLAMFTYLYILSHLAMKQNKFVGHSGWNYDDETGFGVTDIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8R6</accession>
    <name>A0AA38J8R6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1040004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8R6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="443" mass="48039" checksum="687A9C327911625E" modified="2024-01-24" version="1">MLWTVFEESSEDGNSYIGPPPGDLDSFYDLGSQPQSDSEDVAPVESGPTGYSNANTKKEIGEKRVEDMVVPAEDELEDRQRKDVSAEQSVDFPDGGLRAWLVVLGTFFSAFASFGYVSAWGVYQTIHILLYDCYRHKHNTFVSGRLVFDLGIFKLPFCGASILVVVCTLLVGQCKQYWQFFLCQGVGIGISCGMVFGPAMGIIGQWFRKKRGLAMGFAALGSSVGGTVFPIAAQRLIPRLGFSWTMRILGFILMFVLVISNITLARRLPPRNVSGGLFNLAAFKDPPFSTYAIAVFTGFLGLYTILTYIDLSALAVGLSPDMAAYLVAIANMSSGLGRIATGIMADRIVITVLYGFMYGSFVSGLLLPVYELEEIADAGQRTGMIMSIGAIGALFGIPISGEINKASKGFEVVGYYAGSTITVSAVFMLTTRQLVLKRLRGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8Z0</accession>
    <name>A0AA38J8Z0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thaumatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_756496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8Z0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000004">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041429857" evidence="2">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="28"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="96"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="150"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="256" mass="26329" checksum="8C461C2E869ED38A" modified="2024-01-24" version="1">MIGIFSVISLLLASGANADRTFTVTNNCDYTVWPGMFTNLLVGTAVPDQANGWEQAAGATVSFTVPDNWTSGRIWGRTECDFTTVQGPTSCATGGCNGGLVCDASTGTGVPPATVAEWTLSGAQDLDYYDVSVVDGFNVPIAVTVSDTSCSTASCPANLNSDCPSDLQVLDSSGAVVGCNSACNANLDGDQADSANCCTGSHDTAATCPPSGVTDYDFFKDACPDSYVYAYDESSGTALWTCPDSASPGYTLTFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J968</accession>
    <name>A0AA38J968_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1099082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J968"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041215490" evidence="1">
        <location>
            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="266" mass="29808" checksum="2EC6476D5150EAF2" modified="2024-01-24" version="1">MRLAAAFALFSDLRAAVRVAFWPTLKDLYHNPALILHVSRTFMTHVWAAFSASTDQNGRLVKRAFLPNATGTVLDLGAGFGHTIQYLNCSKVTKYVALEPNAEMHSHIRRTAECAGFRESDGSLVILSCGAEDTMQILEVLGGPHPVDTIISVLTLCSIPSLKGVITSLVRDVLKPGGQFLFYEHVLSPRADVAWWQRFWTPLWSIFFDGCRLDCPTHLHIGNIKYVDDDGKELSIWDEGETWGKPGESAENLWWHQAGQFRKRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9P5</accession>
    <name>A0AA38J9P5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_997270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9P5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="182"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="332" mass="36932" checksum="2DA78EE8E90F5E89" modified="2024-01-24" version="1">MILASRRTDSTFEDIPIIDFTDASSSDPVRRMMLAEKIRDACINVTNHGVPEDIITDAVEAGKKFFAQPISSKMDLDIHKAKNFKGYTALLGENTDPTGRGDLHEGFDIGWEEPSRSISKHISSCDDSVMSGTNVWPDLSGFKQPVLSYYHSIVQLGLRLFPLFALALDLPENFFEDKTTKPAAIMRLLHYPPQSPSAPDTDSVIGIGAHTDYECFTILWQDTISALQVQNAKGKWIDAVPIPGTFVLNIGDQLARWTNDVFKSTIHRAINRSGQERYSIPLFFGVDYDVLLQPIGSCISPEMPAKYEVISAGDYVRSRLEETYAHSSSAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAS9</accession>
    <name>A0AA38JAS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xylitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1101138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAS9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="10"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3716345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="376" mass="40292" checksum="E7B95CDB53E42DC2" modified="2024-01-24" version="1">MSNNPSFVLRSIEDVAYEERSVPEHISDTEVLVAIKKTGICGSDVHYYVHGKIGDFIVKEPMVLGHESAGVITKVGAKVKHVKVGDKVAVEPGSTCRVCEFCKSGKYNLCPDIVFAATPPYDGTLARYYRVLGDLTYPLPEHLTLEDGAMMEPLSVGVHSVSNLGNFKFGQNIAVFGCGPVGLLCMAVAKALGANKIFAADIVPSRLEFAKSYVGAIPYQPLSPSTDESKLQYSKRNAENMKKTLGIEERGANAIDLAIDASGAEVSIQTALYIVGTGGTMVQVGMGNPNIQIDLAPMMTKEVSFKGSFRYTHGDYPLAISLVAQGKVDLKPLVTHRYNFNDAIAAFKATRAGKSEDGKDVIKAIISGPDVSPNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBH5</accession>
    <name>A0AA38JBH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1125117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="258" mass="29616" checksum="0B92BC17ACC4509C" modified="2024-01-24" version="1">MLTTARALLFVYGECGQFVTEEQFNDWYDNEHAPLRTTVPGFLTAVRYKALDAPPKAFPKWLALYDLSSRDVMQSQSYKDLRLKASDNEKQVVGNLEVLNRRVYELFDSSESKDTASSGSDRAAKFIYVVHMQVVKNKDQEQEESKFKAQEDHFIRWYTSTRIPRLAIVPGYTRSRVFRLAEHAELAGRASSSGHAQSPFNLLAIHEWNVEGAEVVNLPEFKMCMTDAESWKLEGEETVAVMEDRLFGLYKVFHQVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC51</accession>
    <name>A0AA38JC51_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1206964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC51"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3719074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="516" mass="60734" checksum="D69B4905CA51F8A5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC55</accession>
    <name>A0AA38JC55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="10">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1066711</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC55"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="508"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3733781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="585" mass="62556" checksum="628F8C087E8CDFCF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCK8</accession>
    <name>A0AA38JCK8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1039322</name>
        <name evidence="3" type="ORF">DFJ43DRAFT_1044430</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000123">
        <property type="protein sequence ID" value="KAJ3711135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCK8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="271"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="511" mass="56737" checksum="502B8E03BF6C34CC" modified="2024-01-24" version="1">MSTETLKSLLNPQTSVQSTPNQAPDSSANNEEKRKRAANNEAVGGTNKRTKKSIPPAENARGGQIKSSSRSKPELEGLEEDPVFAESSEDDEDNEAEDETEAFQISAKELALERVKVIERKAQVKSRNPGNVPALEENDNDYILPPASGTVSVREDDAMSDMSSVVDMSMLPSSEGEDVDKPLMKASQRGKAARDAKYQAERPAMASFTNEGHKEKTRVHPHAASMEDLNIGWPDSTHLVYPNQQWTISISLQQQAIKDVLHEGILLAIGLAIFQNGFAPSDKQLTGSRNSILSAARSLKHVQIANRVEHDTQYARHLTNYVTGQVGNMRGKLKEVAQELVPSLYGIHQVPVTDKTTLHANKPYQHPAIIAIMQKFFFSGNKSPGRRFRDTFSSISDQDDAKEIPQAMLGLVSVAVRWDIPSMSWYLCRSQRKDGGHQRKNEDFASANFNDQYELHMKFIGAKILKLDRSGKGKYHSLMARLYREANSSTSVVDENDSNLLPDLDFDGMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD58</accession>
    <name>A0AA38JD58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1070435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD58"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="3">
        <location>
            <begin position="646"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="872" mass="97200" checksum="DE6735ECF30C66A6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD93</accession>
    <name>A0AA38JD93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1003228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD93"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="3">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="580"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3724198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="833" mass="95017" checksum="CA841F95728E1D4E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDD9</accession>
    <name>A0AA38JDD9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1082947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDD9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="265" mass="30357" checksum="A42F5E01F5E8D8C6" modified="2024-01-24" version="1">MIVALLLRAYLRARELFDDEWRYGRIKDLPFGLILKIGRSTTAAEATTVNFIRSNTTIPVPRIIASDRAFGRTYMLMREVKGRDLQDMWPQLDHNQRIKVVAQLRSYVAQLRALSPSLSRGHQAGAVCGLHYTSTRDSRIASATPTGPFPNESAFNDHLILAAEPFMDETTLPAIRARMRDDHRICFTHGDLAPRNIFVEGDKVTAIIDWEESGWYPEYWETVKGMWSTIKDPEWHEAVKFIMGGDFEADWRLDRELSDHMVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDW0</accession>
    <name>A0AA38JDW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1081276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDW0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="526" mass="59266" checksum="DF9FF04598BD53ED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE79</accession>
    <name>A0AA38JE79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1157590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE79"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="295" mass="33247" checksum="378DB9630132E5F7" modified="2024-01-24" version="1">MNWHCGDPPVPIAIVELAPSPGTSLRTRATPKSTVHSPTRTKKKNVASEYYDVSDPFIDDSELAVRKFFAQTKQQGFYVSSGEVALMKDRSLKKPKKSGPSSQTPRISHEGTKESPITLDDDDEVPDAYFPRASENGISKDRKKNLHAAGVFHDIKDNEGSPCQQQLDLEVVVMCRGVRQWIYDIKSVDTTPKNKDKPIHYTEMITFSRDLGSHFANAADQMADYAAIFFKKHPNSAQFLAIIGSGPFWRYAIVGPADCPWSEPGQRLPESERSRKRSDAEWHKVRQIYFMKEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE86</accession>
    <name>A0AA38JE86_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1106993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000113">
        <property type="protein sequence ID" value="KAJ3711872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE86"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041465412" evidence="2">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="81" mass="8433" checksum="CF086052F42EBB02" modified="2024-01-24" version="1">MVRITLLVLATFIGASAYASPIAYRPADLGRRAFAGNSVEPSQGDLGRRAFAGGHGEPVKEDLDKRAFASNGSEPSQGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEK7</accession>
    <name>A0AA38JEK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Opi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_426935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEK7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="420" mass="47059" checksum="90CCD8E9A11342F9" modified="2024-01-24" version="1">MDDSSSQSSIMPSESSPRLGHSTQSSMSLASSSTLLDEQDEDVRIAVKALGDMRSGNIGGAASRQEPDFVSRMAHIPLVNGAIRMYEQGKASSRVVKYGAEIMETGVKTISRPVIDRLPTGQLDDFACRQLDRLDRYRRPSQDASDRQDQEEMQRLLHSPTYGPQEDLDAKEREDEVGRWVKMTSSGSSNLRSPTPTRSSDLRVRHDANVDPSSTRGISSDPFHFSDNSSYILGSDDQRRRPPSYTHAHDQQPQDNQQQQVVQRSRWQTMLLEAGGFSVAWSEESMRKLRYVLQWLQYATNHIDQQILAIRDFTEALQQHYFEASPLEPTIPTDHSLPSLASTRGGHSRSASGSQSQTISSAHRHKLNSIQRDVTQTVRNVVTVVSKYGGNAALPEPARNAVKAFILQLPKKYESCRFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEP8</accession>
    <name>A0AA38JEP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_801268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEP8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3717245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="554" mass="61458" checksum="48AD5B09CDE37FD2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF39</accession>
    <name>A0AA38JF39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_492338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF39"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="412" mass="45637" checksum="C638F2CC9B7E8194" modified="2024-01-24" version="1">MANPSVSTVNQQMWDEALKSVLSLSKATIKHNMELEARVSELEMELSVWKRAHSVALEASERDNLHVASLQQASTPDDFERQSGDPLVLCVINGQQTFFNQTLLTQGFMGGQSAAQYLTRAISEYLTSEDIQITGRLSFLSFWVSIYFNKSELVNMLVGQSICSREQLEGFLAGFSETSPRFTAVDVGIGEGAADRKIREYIRTYTRLPETLRTFMGGCHESNALYSGAFDCLQSENLLEKLVILRGLSEDWSDHTFPIHVLNVDKLLVQQAPHPSMQQLAPLGVPFLEPAPGPSNGGLVSPQSPVRNGLRYPDPRYPLHKQNPPPCNEHYLMACSKGAGACKYSHDYILSPEQLAVLAANAKKAPCNWLKSGLQCPYGKLCCWGHVCPGGSHCFHLRKGKCWFKGEGMHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF79</accession>
    <name>A0AA38JF79_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_581453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF79"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3725597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="352" mass="40058" checksum="FAFE793918BE7DC6" modified="2024-01-24" version="1">MQREILWNATTQFLRAQRIMTGRTNTAQRLSQQLRLLSSQPSSEMTSRQYFSLFLFLISDASTEYSPRLIGAPNTLEHRVFVEQNGSVVSSFHDIPLFADPNSGIFNMIVEVPRWTNAKMEISKEEPFNPIKQDVKKNRLRFVRNCFPHHGYIWNYGAFPQTWEDPSQQHAETKAKGDNDPLDVCEIGEQVGYVGQVKQVKVLGIMALLDEGETDWKVIVVDIQDPLASKLNDIEDVERHLPGLIRATNEWFRIYKIPDGKPENTFAFSGEAKNKKYATEIIHECHEAWRRLITGESSTHGVSIENITISNSPGFVRRDDPKYLGIPPPSGKPPAPIEPSVSKWFYISSAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFE7</accession>
    <name>A0AA38JFE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_975510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFE7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3726403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="96" mass="11045" checksum="C5AECC011C9A23CF" modified="2024-01-24" version="1" fragment="single">FARDGIPLKTIEDFIKDPHVNAPKLRNTRLDKFAADPKSMKASPWNRALAHRFAEKAAEIAANSNDGRFGPHPIDWDKLFSDRLYRVYKQIIEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFG6</accession>
    <name>A0AA38JFG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1122935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFG6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="346" mass="37208" checksum="35B0150BAE5B1CF3" modified="2024-01-24" version="1">MALPTTTKHYFWSKLGALTNLSSKESQLPSLKSHEVLVKIYAVSLQYRDLIIGFNKYPGSFPDELVPCSDMAGEVIAVGDEAGSYWKKGDRVCANFAADHIAGETSPEIQKTAHGGAIHGVLTQYKAFRPHSLVRIPDHLSFEEASTLPCAALTAYNALMGPVPVKGGDTVLVLGTGGVSIHGLQIALASGAKVIATSSSDEKLKIATKLGAHHVINYKTTPNWHEEVIKLTGGRGVDHILEVGGADSLEKSLKAVRVAGWIHTIGFVGGGDPTDVVFSTIRKACFIRGIQIGSVAQFNDMNRLFSLHPEVTRPVIDKVFPFEEALQAYEYLQSQAHVGKVVIKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFU1</accession>
    <name>A0AA38JFU1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1132739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFU1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3730887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="239" mass="26604" checksum="50DD2E894F6C937A" modified="2024-01-24" version="1">MALLFGNKLTLDPPSSPGTMPTSSTDLKATVKDGYDAIALRYHNWAAPRLTQKRTEYIERLGQLLPKGSKVLELGCGAGLPATQQLVDQGFQVIGVDISSSQLELAKNHVPAAQFMQGDMMAMEFTEGSFEAVTAFYSLFHLPRDEHGPMLKKMVGWLKPGGWLLFNLETKEDDQMLDDWMGVKMFWSSLGIEGNKQMLVEYGSGLTNVEDVVDKEVVGRFEENFHWICARKKPLNISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH10</accession>
    <name>A0AA38JH10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1061933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH10"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="2">
        <location>
            <begin position="93"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="418" mass="47778" checksum="74ADD3A812508871" modified="2024-01-24" version="1">MTTVSLPFPLPQLEPSSAAEPARQHLLSQSRFPFSISLPNLRAPHSSKSKRKHKVDHTQQDANLTVGAVAEENSQDPLTIKLTAPGLADDDLYQDKYEWVVLYENQRGVTLFSIPYYSSNSLLPSDPAPFTMPSSVSLKRAHQPNVSLKEYPLPDGNWCWVSNSWMVDMRSDSGEVQHDGFEYNWMFRKHHWHPRVGALSAGGWVRRRRWVRLMMRPGKKRRMVIEDGDVQTPTITSLSLRSSWNGWDKRLSASPSLFTNATDRRDTFYLPEVWQGDADEDWLMCREIMKAAASDGAKLELWKRWLGLSEPTDPPLTNKGKQKEVSDDDKSLEWPSVPPLEHVIAVLRAKLTTILKRFFIFPESRRVFIELMFKAEVFDQVSGLEHSMTLAKALEFWSLSSELGDLSSFVRSSKSMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH24</accession>
    <name>A0AA38JH24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_298583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH24"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041220500" evidence="1">
        <location>
            <begin position="29"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="243" mass="27132" checksum="D94B8E39DCE798B5" modified="2024-01-24" version="1">MQLLFSSLLKLSSTLFVGLVLLVQSVQPVPITSDPTLNSPTESNQLRPGVSDIVTPSQIHARDPNLPIFVDIWVTAKEGRSAGIPISFFIALRDALDTMLDLVKPSIVKAINTHENQFLPDESTIQLDSLYVPFSSLTNEITARCIFYGPHTRWIHPHTEQHLTWIARIEGESIHNGPAAYRYEPGLLTGTLAVGGQVILSVQKGRYQEGPWDKDKTGVLLPEKTETERHLTFKDNRAVRFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH37</accession>
    <name>A0AA38JH37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_809611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH37"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="110" mass="12450" checksum="BA9A13FFECAF3729" modified="2024-01-24" version="1">MREGDTMRFLYFFIFRNQFTGCAIVYLSNLASHRLVDLGRKGCLVQFFFSSVLFAFALHSAYVSEYAFGSMSPGESTHGHMAHNNGDNQINGTYSLRGLYRFPAVKSMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHN1</accession>
    <name>A0AA38JHN1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_399507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHN1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="720" mass="81549" checksum="4220814DC3A5D775" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI99</accession>
    <name>A0AA38JI99_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_458035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI99"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3730930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="280" mass="31249" checksum="D920FC2427B7A130" modified="2024-01-24" version="1">MPRAKSLKDGRPNEANMAATCSVCQAVISNKTDLPRHMRIHSADKHKFMHRCPYTECNFENLQKSNVETHIRTHTKSKTNNCPDCDFTTVDPGSLTRHRKRIHGYIPKTRRSRHPKPTPTATGSPIATSEDASSHIHDTDEGTSSMNLQTQNPEFMIGPHHAQSQPEPPTSTELLMRTNFNQAPISRFITTLSSSTSISAPVPTTLKRVSRARIEDEEGEGRKEFSDKDGFWKSSLGPRQTPPAEGKQVDVEEENSLTNKPSGLVPALEYGTRPRPEIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIE4</accession>
    <name>A0AA38JIE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1038631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIE4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="259" mass="29633" checksum="602ADE178B6A0723" modified="2024-01-24" version="1">MLEAALGETISNLQTTVKNLSAAFEHKIKDARGQDANTKSITQIWKIESKRDDLMGDYNLFRGALKALDNLDKVKWPPLELKDTFRKSSEHHRTPGDSRVLEGNLWSMTSTGHSGQAVQDITGALLGYNGVDEDEEGGEGDEPKFVTEMLKYQGTQMLMRQVQPVKLSPSKAFKDGPDILEHAEQPGVDADGWIWSARRLKNMSLKEVEIWEDTNNRIQWFWAEADFERWQEQVETKHAEFPHVKTVPVRLRRVLDEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIJ0</accession>
    <name>A0AA38JIJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIJ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="666" mass="73906" checksum="FA44167C0127E254" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIL0</accession>
    <name>A0AA38JIL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1226011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIL0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21143" checksum="3A377061A149B831" modified="2024-01-24" version="1">MAVPSNMSILNISGKFASNKSLSDNEASDDILRLQGMGWVKRKIIGAGTLTLAIEHFKNADGVECINIEQTLNPGGLKTNDERVLDWAEKAKEDSVFGATIGQNRRVKAEDVEDEYLREGWTADTLEHGLIQSRVVSDTAKSGVSWTVNQTWGIEEIKGERRYVRHMYMKGPKDEEVRGRLVYNYIGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJQ9</accession>
    <name>A0AA38JJQ9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sec20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1129308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJQ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="145"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3736629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="371" mass="40101" checksum="AFA9A1378CD091FB" modified="2024-01-24" version="1">MPPLPSTFAPQATQLISSIRRREIDISDVQIPRLKICPGPLSLHQKLSMELREDMDVLARSIEDLDAMIDDQKGPKNRRELKIIVDELKQALAKSRKDYRAALLLSKRKIDTSSASNRAELLAPTIVRDGRDVNEKATEDAVMQANNNVTEALQRTLSLMQGELERSVLTTQMLDSSMSALRGTSSTHDLLTNAMDASQQLITALQKSDRMDRLLIFFGLLCFFLSVSIVLKERVLDRSVRLAFWWTRFLPSGSVSNLGSSVASEASASVSGTAILATSSSLAIATVSGISLVPTGTSIVSSASPPSSETEGSILPPLSSFLSSAIVDSTPQLSSVLETNHLPKVSASSTSNVQEVPLQLSPTTSNAHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJV5</accession>
    <name>A0AA38JJV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_517118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJV5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="112" mass="12755" checksum="A6C7EC04DB2FF949" modified="2024-01-24" version="1">MTIAGDSDHAEPCLPFGFLHYALSQAPQQTRPHPRQLAPWSLQHQLNRRALYARLVSFTQNKVSIESVELGIYNTGNKAAEVFSAKGESCSLVWHIKTPLWTPLWTQQRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJW0</accession>
    <name>A0AA38JJW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_489736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJW0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3728963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="368" mass="40966" checksum="474E87E449766BE9" modified="2024-01-24" version="1" fragment="single">MLRVVEGLRMLWFVIEKCGAIPELEDKEGESGIHKASLNGHLPIIQYLLTYAHVDPNTQDGDGWSALHNACSKGYLDIVQYLSDTNININIQNKTGYTPLMTASSKGHLPIVNYLLNTHSADPLMRNNYGETAYDLAAAVFEVGICEVLVEAEKRRFGEGDKLGEAGLGKGLGKKGKGGLGKGRYNPLEVHTTVPVVVLEIQVQRKGEAQSQQLQTRFELCLGDETVELSSRDVDLPWLDDPFTFPFLSPQSQSQSQKPQSQSQSHSPKSHFWLSDWTLDMTHPNIDLSTGWEYAPAPDQTPTQTSTRTATRTGTQTRTRTRTVNWTRRRRWVRLVRRRLDIDPLPFLFPDGGIMLLRGLNGGGLGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK99</accession>
    <name>A0AA38JK99_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1153922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK99"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="240" mass="27769" checksum="5383A25998B46F64" modified="2024-01-24" version="1">MSSNIEGMHDPFLFSAPTAALNIPLTARKIHIRRLYEVLQLSIHRNDLTRARRAWSILVRCKEISWITIWNVAIHLVEETSYGDDSARKIELLRDMMLHYPDQRMAVIKELVFRLIFSGRHREALDELELYLPSFPYQDNPVLHVYAGLLCFYLAQESVNSETPASFQPSFIREATAHFERAQMLDPGNIVATSFLHKIAVRSLEFNIRATQLDDSDDEPIIQDVSHPRPKRLRQTMSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKH1</accession>
    <name>A0AA38JKH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1142866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKH1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="425" mass="46928" checksum="436EE1ED89F2486B" modified="2024-01-24" version="1" fragment="single">MRHGIHRTRKLPSSTLNCTVMSTIYSLLHNNLYSGQTARREELLALTLLHANDNWRASTKHVHGKISKAALILCKIFEEESPPFGLYPHQIKKLATWANSPAGSRSLLGNMLPNDPHLYLYLQSGNLLQSVIAVTGDTPKVRMWVRAHAINQYADAERQSREGVSNTDSPSSALVIHTGLRNPKRSLESDEIPGERAQKFRTRDRENRPSSASSSRCSFTKASPRPKYSRTFVNRKLVDGDLEPWANKQRITSDTASGDKRIGFRDGQLEDIPQVEVECKPRSAKEITMEDLEPIEKLMYPTTIDTLQDGSNSGVTDLESAVTVDSKDLSSTANLIHNSSSDIKLSGSILNPPLGEDSISLSLEMVPYRPSNIQTRSDNANSCKLTICFAPASSASSFNNPIQIPSLDRSRSVNPIAPSLPVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKL9</accession>
    <name>A0AA38JKL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_999845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKL9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1030.10:FF:000002">
        <property type="entry name" value="cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="408"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3731016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="768" mass="88711" checksum="62AE79B4E5486B90" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKN6</accession>
    <name>A0AA38JKN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mediator complex subunit 16 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1074417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKN6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="2">
        <location>
            <begin position="809"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="873" mass="97764" checksum="FEAEE479CD841F98" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKV7</accession>
    <name>A0AA38JKV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_999654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKV7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="23"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3731031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="358" mass="38005" checksum="322806E7752D543A" modified="2024-01-24" version="1">MVSFTIPKTQTAAVVDHSGADIRIDHQFPVKSQEELLPGECLVKLDCSGACHTDLHAALGDWPLPAKTPLIGGHEGVGIVVAIGNNTANSPVKLGDRVGIKWLADSCLNCEDCRKGREQNCSKAKLSGFTVDGTFQEYVVSFVNHVTPIPENIASDEAASVLCAGVTVYRAIKYSQTVPGDWIVLPGAGGGLGHLAVQYARVRGLRVIAVDTGDAKKELCLKLGAEKWIDFVECKDIVSEIVSITGGGAHSAVVTSANGAGYRQAVDYLRPGGTLMAVGLPGKATLEASIWWTVFKSISILGSYVGNRQDAIEAIDIAARGHVKVHFACRPLKDLEDVYEGMKAGKIAGRIVLDMSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLQ2</accession>
    <name>A0AA38JLQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1062653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLQ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="382" mass="43059" checksum="BB31D9EE2AD9295E" modified="2024-01-24" version="1">MIGLNYEAPRHGSLGFLPRKRAARHRGKDDPKKPVHLTAVMGYKAGMTHVVRDLDRPGSKMHKREVVEAVTVIETPPMMVVGVVGYVETPRGLRTLTTVWASHLSDEVKRRFYKNWYRSKKKAFTRYAKKHAEDGGKSISRELERIRKYCTVVRVLAHTQIRKTGLSQKKAHLMEIQVNGGSIADKVEFAHGLFEKPVEVSSVFEQDECVDIIAVTKGHGFEGVTHRWGTKKLPRKTHKGLRKVACIGAWHPSKVMFSVARAGQNGYHHRTEINKKVYRIGSGSDEGNATTEHDVTKKQITPMGGFPHYGIVKNDFLMLKGSIPGTKKRVITIRKSLMVHTSRRDLEKVQLKFIDTSSKFGHGSFQTFEEKAAFLGTLKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JME3</accession>
    <name>A0AA38JME3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_272753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JME3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="346" mass="38724" checksum="52DD7FEBDAEB58E3" modified="2024-01-24" version="1">MDHDDPIATFFPGEDFVDLYTVISVSNNCKLDEIKKSYRRLALKYHPDKHATASESAKAEASLKFQQVGFAYAVLSDEKRRKRYDQTGKTDEAFDLAAGEDGWEAYFEQMFDRATRGKLDEMKKEYQGSSEEASDLKAAYTETQGSIGDIMTFIPHSTHEDEVRFILILSDLISKGELHSLPKWESSIKDEKAKLVRQKQGEKEAKEAEKLAKELGVWDEFYGSGKTGKRKGKGKGKEEEGEEDVSALQALILNKKQKNTDSFFDSLAAKYAEPAAKTKGKGKKRAKAVDDEETDESPKKRSKKAAPPPPDIDDAEFEKLQQKLFGDKAKGSVESVGKKGKGRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMN0</accession>
    <name>A0AA38JMN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UbiA prenyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1130941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMN0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3733873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="315" mass="34841" checksum="EE559FC272A7EC88" modified="2024-01-24" version="1">MSKRLANLIAPPSREEVNACWELCRLNNNMGCWTTWIPTAWALAMVYHAQPQISGAAALTWAAKYFVLCSGIKSLIMTIDDILDHDIDALVVRTKSRAIPRGAISLDRAWLFFSIQVVLGIYLARTLLDPVSCRFAAVAAPLFVIYPTCKRWMYFAPITLGLMFTVGVFMGWSTLSLTNQLPYEILVPIYIGGCCWVWTYETIYQHMDKVDDIKIGIRSSALLCGRHTIPICSATAITFFSLLMYGGYLNGHGIPFFVGVLLAAVLLLSKLLRTNVDCPGDCRDFFLQTPLIGQIIVGGFVADAVIARISNGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMX0</accession>
    <name>A0AA38JMX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1223396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMX0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1228" mass="138334" checksum="A5F18001088FD202" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMX8</accession>
    <name>A0AA38JMX8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_503856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMX8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041259251" evidence="2">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="174" mass="19162" checksum="B3C8870AE71CB376" modified="2024-01-24" version="1">MRQIKTRSSVFSLTLACLSTMSNVVFPPYPSSPSVYDYASTSPGSRTPTRPKRLASSVVSNPHLDQFSPEYTTAIHQSVTGHFSHTMSAPYEGNPITKDVQRALRAQERAHLRKATLGSSPRNKKVLVARAPSGKPQALSPSRHNTNVSLTSPNTVSDSQENRIPTKVERREFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNW4</accession>
    <name>A0AA38JNW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1153449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNW4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041353680" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36192" checksum="CCF4D73261324737" modified="2024-01-24" version="1">MQFPLRLFKFLTIVWFSAVEALSISFLPEGTPTAGLKSQLVLWKRDTSDPNTQFVLQKIKLNDPDGPTPKSTPVPILNSQSDEGESPMVFNQAGLFQIIAVDKQNEQTFFSTELTVLPNPTSSASLSSSNTFLSESLGSSIGTPTSLAGPAASDSDYPAATSSSTVGPSTVDSKNGNHTATIIGVTILGIVALISIPGVIFLCLRWRKGRHRTNFTASFRQSRNSQVAESTVQATTPVTREVARTQGDNNDSDVLSCATLVNNDARPISYAEAHLGVNEHNRSVTALSSTRKTQTNPVAMIFRHQDSGWRDLSLEHNQIHADMGMIGLPPDYETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP63</accession>
    <name>A0AA38JP63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1080600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP63"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="578" mass="64057" checksum="6474840AC2795BBB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP70</accession>
    <name>A0AA38JP70_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1040273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP70"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="117" mass="12866" checksum="3E4819068AFAA20A" modified="2024-01-24" version="1">MVGTQDCPRVEAATPLPPGEAIEQLKVHLRFWTLSCFLTCKNPYIVILAKCRKGGRTPCLFPVGKGRRRAGKDGQAHVEALIGIQERATGTKRGDAEAKEALLTLDIAELWPDQLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQR6</accession>
    <name>A0AA38JQR6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_384988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQR6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="100" mass="11586" checksum="02BC2A6C73D3DD37" modified="2024-01-24" version="1">MNAHKDVVEPSHWPKNLRYIQSYTYHSSVSLETKNFLGRGPKFTDRRSPSRFVAIRHITDPLHPAYNQYGLFASKKIPAKTHILDYFGEIHADERLTSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR13</accession>
    <name>A0AA38JR13_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1037724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR13"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="295" mass="33620" checksum="3BCD4E0914079DBC" modified="2024-01-24" version="1">MPRKSQARTKAKVTTQRIRTSSDNESTAGYSPGADSDLTSADSSQYHEERTAFLEEEKSQMVAYLHDVLKTTITQRTVPFPLHVAFAEDVPIENRGMAPPRGPGSTVGFWEWEGERYQWGIPLSQLVEGRSKLADPNEMAFDFRELFQESVRFELVWPGYLHRRWLVSVPLHDYCGGKIRWTKKELGRFIACQYRKFAESCDHSIVCKEPAWRIGSGGIAFEDMRIVTFWNITKDIWRAEIAVDGLNNGWAGSRQEYYSLTGAEGCYSKIIPEGEDKRCPSCGTVHEPDPRLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRC3</accession>
    <name>A0AA38JRC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1129416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRC3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="117"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="273"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="839" mass="89511" checksum="63259898FF6949CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRJ6</accession>
    <name>A0AA38JRJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_261012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1327" mass="143393" checksum="62B3AD1E64AFC3C9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRK5</accession>
    <name>A0AA38JRK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1035769</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRK5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="179"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3736984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="489" mass="53347" checksum="7C255550564D147C" modified="2024-01-24" version="1">MATGDIGLIGLAVMGQNLILNMNDKGFTVVAYNRTTEKVDRFLANEAKGTKIQGAHSIQELCSKLKTPRKIVLLVKAGQAVDDFIAQLVPHLEKGDIIIDGGNSHYPDSIRRTQELEAKGLLFVGSGVSGGEEGARHGPSLMPGGSPAAWPHIKEIFQKTAAQAYGEPCCDWVGETGAGHYVKMVHNGIEYGDMQLIAEAYDILKRGLGLNEDEIADIFLKWNKGVLDSFLIEITADILKFKDDDGEPVVAKILDQAGQKGTGKWTAIAALDAGSPVTLIGEAVFARTLSALKDERTRASKVIAGPQKEPFRGDKQMFIDDLEQALYASKIISYTQGFMLMRQTAADLGWNLNYAGIASMWRGGCIIKSVFLSDITKAYNKNLKLESLLFDDFFNKAVHKAQPGWRRVIAQAVLWGIPTPAFSTALAFFDGYRSDIVPANLLQAQRDYFGAHTFRVLPGKENAKFKKGEDIHVNWTGRGGSVSASTYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTX1</accession>
    <name>A0AA38JTX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily multidrug-resistance, DHA1 sub-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1143799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTX1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="17"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="494" mass="53511" checksum="EC0EF3F90FE89BF3" modified="2024-01-24" version="1">MSSSSIIQPRTPLPKLQLSLILLIQVTEPINAEVIYPFIIGAVRDTGITCGDEKKTGYYAGVIESMFFLSECCTVSVFASSICHVNNPNQVYYWGRLSDIYGRRKILLIGPLGLTLAMLGFGLSKTFLALVIFRALQGIFNGNIGVAKTVMAEITDSTNMADAFTMIPIMWSFGTTVGPALGGILANPATQWPQLFGKFVFFRDFPYFLACAAAGFMAFIAFALAYIGLKESSPTFKSQEMENVTSSDESEPLLQDDETQSNYGSSTSSTGQIIGEHAQPLSAWELLTGDLRIVLLNYSLLSFTDMSYTVLIPLVYSSSISIGGLGLSPYQVGLILGIFAFLNGFWNLFVLTRILKKLGPRKMYIISYSSYLVIFPFLWIIRDVAHLAGGVNVLVWILLVCQLLAATFINTAFNSMSLLVVQSAPPNALGSVIGLAQMTASGTRGLAPLFASSLFALSLESRIAGGHLVDIVLIVISALGLFCSFQIPKHGSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXZ3</accession>
    <name>A0AA38JXZ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_107644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXZ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041340748" evidence="2">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="194" mass="21139" checksum="B779470816CF5D22" modified="2024-01-24" version="1">MRLASAYFMALCSGLFSAALAVPISSGVTLHPSPEDNLVALLQSRGLHYFGTDNASPPKPESPQSSQQQGEEARIEVTFRVGKEGQDGVEIGDKWNVRDVVTSFLRQEQLYTVTSAAIEWKNGYEPERTGLIQLQLKAPNGRCHTVSCRILLIKPVSNWSIGQHISGIAAYTGRAGTICTKLLIVDFQALVHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1H8</accession>
    <name>A0AA38K1H8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1048911</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1H8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="18">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="17">
        <location>
            <begin position="169"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="313"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3737018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="366" mass="40234" checksum="9242CB57FB44AA2E" modified="2024-01-24" version="1">MTPPTFWLRCEKKEFEKRAALTPTTAKKLIDAGFDIFVERDEQRIFDDSEYEAMGCKLVENNSWPSAPVDIPILGLKELPVSNDPLPHTHIQFAHCYKNQAGWVDILSRFKRGKGTLYDLEFLEDASGRRVAAFGFHAGFAGAAAGALALAAERRGEKLGQLNPYENEAAMIDGVKKALGGSGKGVKALVIGALGRCGRGAVDLFRKIGLEEDDILKWDLAETAKGGPFEEILNVDIFINCIYLSSKIPSFITSDTISAAGKDRRLSIVVDVSCDTTNPFNPIPIYNINTTFSEPTVRVDLPSEIPPLSVISIDHLPTLLPRESSEQFSADLLPSLLEFPNRDSVRLWTDAHQLFQKKLGEAEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K268</accession>
    <name>A0AA38K268_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance-associated ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1177745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1082"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1116"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1170"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1267"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="294"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="686"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1369"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="657"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1490"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="957"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1490"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3737438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1661" mass="185160" checksum="5ABC96C7D965A76E" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQY6</accession>
    <name>A0AA38MQY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1101628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000082">
        <property type="protein sequence ID" value="KAJ3715896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQY6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="111"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="850"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3715896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="916" mass="99209" checksum="CF2B8CC376E9791D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MR85</accession>
    <name>A0AA38MR85_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1099566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MR85"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001047">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="279"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="544"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3717268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1228" mass="137493" checksum="9964FE167C529A00" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRI7</accession>
    <name>A0AA38MRI7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1005326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="125"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="639" mass="71139" checksum="790E04160F9A751A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS73</accession>
    <name>A0AA38MS73_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_634558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS73"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3724185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="99" mass="11364" checksum="143F9D15CF4A7DB2" modified="2024-01-24" version="1">MLPAVAFFFSLSNSFCKFVQTPHIAFFSKLQVILLCTQPLNVFSQQTPQFQFPRVLKYVFCFSTLTCDYTNYLFSESISLLYLLPNVFLTPILEAARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSB5</accession>
    <name>A0AA38MSB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1089173</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSB5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="278"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="453"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3725571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="736" mass="81882" checksum="C8C16A091A94D30C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSC6</accession>
    <name>A0AA38MSC6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_573806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSC6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041304232" evidence="7">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3725661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="370" mass="40029" checksum="38ACDFDEBCAD047C" modified="2024-01-24" version="1">MSMYCFGLSTTFWGLVLSRSLNGALNGNIGVIKSIMAEMTDSTNIAQAYAYMPIAWSTGGVLGPMIGGALARPADQFPHLFGDNEFLKKYPYFLPCAVPATFSAIAWLVTFLFLQETVQAPTFALPKLLRSNKKLTGKISPVSEINDVTIEIPDNEKPVPFRKLLNRRVLIAAGNYATLSLVDIAFRAIQPLFFSTPVELGGLGLPPSSIGNLLSIFGLLNGVMQIFFFAKLHDYWGSKKTFIMGIASTVPIFACFPILTYIVKSNGGVTPLAWMFVALQIILSLTISFSYGAIFIYITAASPNRASIGATNGLSQMSVSICRAIGPAASNSLFSLSMRYHYMGGFLVYYVLLGISALALVTASMLPRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MT53</accession>
    <name>A0AA38MT53_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1079591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MT53"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="361" mass="40671" checksum="91F2AD94FFB193B2" modified="2024-01-24" version="1" fragment="single">KVEPASAPGLFTRKARSYPGDEHSARETISQGHTEGSIIGFYALIDIHRSISLRRILERESGASTVTAAEGIIEAEFSLPPWAKRSIFMDGHGVSSKENVYDWPSIRVPSVEQPHLTKSSDRHYAYWVAVHGTIIDHPGIFITDSGFIDLDTVAGHRLLRALDFAPSSESSSFKELFITLLTLPKFYSQLVEVHRLNITPTIQPITCPYEPKAIVDVARHMANCGITESQADSLLQYARFFCIDKLQSKLRSEDETGPWLKILRRSNLRMLVTDCVPERDPTLELPAHWNRDDLKEYRRRRAVIHGQKSRGQLPLNWHMRHEAIPMNPETGNPVEEMANLSLFETNPVVSISNGVQNSATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTF6</accession>
    <name>A0AA38MTF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1078459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTF6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="368"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="637"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3731669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="984" mass="105302" checksum="AA78EEEC8D13825C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTZ5</accession>
    <name>A0AA38MTZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1175518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000175">
        <property type="protein sequence ID" value="KAJ3709507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTZ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3709507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="215" mass="24286" checksum="29B480C1763C9294" modified="2024-01-24" version="1">MSPRRIDSGLSCQQFIPRISPWGLSGRRNLLPSVDSGVPFVPFVPAGLEAQLPRNATGSSIAFSPRALVLLTLITLWMFRLSYNTFRRGLFSLKDEDYRWAVLRKQFDERRREDRIPNCELDIHRCYLECVVGWPAYLASGLGILAVEFTADKQQFVYQTYKYAFLGQVKETNESEAHTHALRAASAVAWPCASPETDLKLKPADARRGFITSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUH1</accession>
    <name>A0AA38MUH1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000126">
        <property type="protein sequence ID" value="KAJ3711072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUH1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="112" mass="12876" checksum="4CAE1C7EC04CDCF8" modified="2024-01-24" version="1">MASEVIAGRYLVRFTSNSDLEDPAQIIGTGSIIKPPFAYNPLHDMESIRWILVYLPYFRKTMTSKISPMLISLIFVVDIARAFAAKLHAGYRKFEANFKLTLVDERHFKIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUN3</accession>
    <name>A0AA38MUN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1131412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUN3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="142" mass="16710" checksum="2923D04E84691F28" modified="2024-01-24" version="1">MSYFLPHLPSGWHVDEAIKSEEDRVVVIRFGYDWDSQCMTMDETLYSVAEKVQNFAVIYLCDITDVPDFNKMYELYDPCTVMFFYRNKHIMIDLGTGNNNKINWAMDNKQELIDIIETVYRGASKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV20</accession>
    <name>A0AA38MV20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_994043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1292" mass="143045" checksum="AA386A0A8F9E36E1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW47</accession>
    <name>A0AA38MW47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1101891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000083">
        <property type="protein sequence ID" value="KAJ3715624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW47"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="276"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="276"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="356"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="356"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3715624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="786" mass="86137" checksum="00FCBC5A95D521FA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWJ7</accession>
    <name>A0AA38MWJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1042593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWJ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF11">
        <property type="entry name" value="THIOL METHYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3720234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="236" mass="26336" checksum="47942E0B67256768" modified="2024-01-24" version="1">MSTDHPLGTRVADIRTFLTEDPQSWDILWKKKVTPWDSGEIQPPLRQVIESGDVPFARGGRALVPGCGRGYDTIYLASALGHDAIGLDASVTAVEAANELVRSESSNPELVSKIQFETADFFKYEVPEDKKFDLIYDYTFFVAIPPSKRLLWGSQINSLIKPGGYLITLMFPQVPPRDPQPYTTGPPFYSNFASYEEVLRAGGSEWEVVLDKIPDDATLLDAHKGKDRIVVWKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX00</accession>
    <name>A0AA38MX00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1098096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX00"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="230"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3718564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="373" mass="40065" checksum="846EAC57D923CF76" modified="2024-01-24" version="1">MLSLEGLEHSHDNDSVSDLLNPNIDSELEHWQKLVFSFDMDGGDNNDNSSFSGSTNPDGRNARSRSHSANQQGSNAPVLPRNDVQDAILLAQFAAGNVLPQPQTTQDPSYNALLLALLQAQNSQHGAPNLQTAINQHLYGQQSISQSNLNLASIPNQFQWPPNFGHQQQNFLFNQPGMPAHMTGYPHLPQINTNVALGASGGSAAASSSPPTAVSRASSPADPADLGITEDKRRRNTAASARFRIKKKQRNLNLERTVSDLSGRADDLEKEAADLRRENGWLKEIVMLKGSRLAGLDVSPQNLPRPPEGNASFWGPTPTNSGSSQPVASSSKKSNDRSQDSESEPESGDDSDGYNEGSIQGGGASSKGKERQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYF3</accession>
    <name>A0AA38MYF3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1189255</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041413836" evidence="7">
        <location>
            <begin position="18"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="54"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="166"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="377"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3730860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="527" mass="57406" checksum="E99F5E28817B8CA8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYJ9</accession>
    <name>A0AA38MYJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1002588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYJ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="3">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="527"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3725529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="652" mass="74095" checksum="F8DD4766AE8AD541" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZD0</accession>
    <name>A0AA38MZD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1039791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZD0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="130" mass="15272" checksum="976E8CCDB1C15E5F" modified="2024-01-24" version="1">MSRRRLTLKLRALYASRRARATSLADRPGYLYAFVDRGRYWKLGMTSDFERRKAQWDNECSRTHRRWLPPVRVMRRQRAGPNNIALIVGELISKSSYFVVIGTGRGELSFDHCFCGLQYSNQHINLKTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZH1</accession>
    <name>A0AA38MZH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1082552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZH1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46190" checksum="DB416F82324D0031" modified="2024-01-24" version="1">MASMVFPSEGMQALSFLIHILGISILTHCLSRRLAAEDWNSWSSLRDMTWARVCILLIFIDSWMFLFASGMLTFGIGLESKDLVCALAIYLCVVFYATSKLLIYSFLVEKVYLVWSPSTTSPQRFKSPIYLGCLGMIAIYGGIIASMFAGRIHYFREGDGVCIIGLKQYSSLALVAYDLLINIVLTVLFLWPVFRVNLTNPRLKAVATRTLLASAVALTTSTVNMLVLALLKGHENGWVCLGSCGADVIFNALAVFWVTKRRGQSYNYPSSIGQVINNPARESRRAPEAKLHGDTGNDLVIGSPPPTPWQTPTFNVDASRQTPSIIGSGPTSPAIRKPKYNLAFTSSPRESRFEDIEMHSTHKPSLFRSMTGLFRSERHPSEHALQVTVTTIITDDVEAGNGAKLSSNEETESQDDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZI5</accession>
    <name>A0AA38MZI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_356236</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZI5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="113"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3731701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="335" mass="36594" checksum="FDB85D24FA5FF7AA" modified="2024-01-24" version="1">MLSRFPSGALKQAASAAKKSSPSLVSSSRSASVRFASSSASSSSNAFESFMSSRLTLASATLFTAGTVAWYTHLYGTLPFIGEVHASHLSDEGLHPAAYPWPHNGFFDSFDHASIRRGYQVYREVCAACHSLDRIAWRNLVGVSHTADEARAMAEEVEYQDGPNDDGEMFQRPGKLADYMPAPYPNEEAARAGNAGALPPDLSLIVKARHGGSDYIFSLLTGYVDPPAGVEVREGMNYNPYFPGGALSMARVLFDGLVEYDDGTPATTSQMAKDVVTFLNWASEPEHDERKKTGIKAVILFSTLFVLSVYTKRYKWGPIKNRKIQYNPPTDKTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZQ4</accession>
    <name>A0AA38MZQ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1076488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZQ4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="633" mass="71015" checksum="98A6ED5FF9CE5A4D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZR5</accession>
    <name>A0AA38MZR5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1075900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZR5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="135"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="208" mass="23745" checksum="C4933ABC6CDFB0FF" modified="2024-01-24" version="1">MSDADESAKLWKVNRTIHELVKDRGFSVSDEEINMDLATFRQSFSNQSGFVDRNVLNFFSNSIANPAEQLFVFFSDEKSVGVKTMRKMLLILEEKGIQQGIIVFPGNMTPSARKVIVAMASQFRLEEFSESDLLVNITHHSLVPHHQVLSPSEKKALLEKYRLKETQLPRIQLADPVARYYGLKRGQVVKITRPSETSGRYASYRICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N027</accession>
    <name>A0AA38N027_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1081399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N027"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="391"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="515" mass="57196" checksum="A4F357E1557BA47A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N180</accession>
    <name>A0AA38N180_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_306777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N180"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="156" mass="17937" checksum="0B10E341113C334A" modified="2024-01-24" version="1">MHVQYMDIEVSTQSLERNENLCIHRCSFMLDFGQDCALITVTLFFFFVHSSLSLSFSLSLCFSLLYSFMYGSCHTRHNILISPNRIQHHHQAFVSSTDGIPYHIITSAHILRRTTLCIYCIQCILSTMTSSCPNRFLLSKQCYFLSPSAYIDLCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1H1</accession>
    <name>A0AA38N1H1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_996024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1H1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="139" mass="15960" checksum="D65C5575FC903FD5" modified="2024-01-24" version="1">MPAPISRIPVALDPTVYYLLGQLEYYLSPQNLAQDFFLRQKMDSHGWIPIPLIASFNRVRQITTDESFVRDVLGMSSVVEIQGDMVRMKEGEWERFVLPGAQTSRVDSIHDFSLTPSSESEDEEEEEEEEEEEVVFVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N254</accession>
    <name>A0AA38N254_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1061206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N254"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="360" mass="39437" checksum="F7506937FD92B892" modified="2024-01-24" version="1">MPITLNPSTADTRKFKVAAVQAEPAWLDLQGGVDKTIRIIQEAAAQGAKIIGFPECFIPGYPWTPWANTFVQAQPVLKLYQENSLALHSPEMDRIREAVKEADVNVVLGFSERDGSSLYIAQATITQDGNIANHRRKIKPTHYEKTVFGDGSAQSIYNVVQTPYGRVGSLNCWEQIQPWLKTHFYAQHPQIFVGAWWPAFPVSQGGSPYIVSGEASSRMTQNVAMEGGCFGLACCHVVSEAGAEKMKMTGFPWFTFPGGGFTTIYGPDGSPLTEPLDPGKEAIAIAEISLDKINEVKIVADIMGNYSRFDLFHTVVSGKNWAPAEYARSEEEIAARKKQAEIDNIGNSNSFIASVDINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3D1</accession>
    <name>A0AA38N3D1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Indigoidine synthase A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1061595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3D1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="376"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="696"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="772" mass="82590" checksum="FC6BDC78109A6F42" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3U4</accession>
    <name>A0AA38N3U4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_992033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3U4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="232" mass="26569" checksum="5C66088424F7FA60" modified="2024-01-24" version="1">MKPILGENTNGIANDVAEIHSIVSEACPVLPEYPDFEVRLARHRWLPLLYVCNDLMVFPADKYISLAASQSISDRAVKKAELAAALRNWRTHEIVEEAPFMWPHFTPKNSPPPEAPWAIPPDTQSIHNLSDTERSMVLQNLMTRMNFNSARHIGDLHRALCAPLNNDLEKRKALELLHIQLSKYNIDALKYVCVDLNRLPLGKLGKPVLIQALIDWVRYIVWLRLNSENDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N462</accession>
    <name>A0AA38N462_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_821896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N462"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="104"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3735677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="325" mass="36729" checksum="C8E78F5459DC151B" modified="2024-01-24" version="1">MYSHRQEHKPPIGATRRRKLLLSYAPDWIITILLGALFFLIERVHGFWRDFSLEDTSLRHPYAVHERVPTFALVLICFIAPLLIQPIMNFLTIRSWWDLHNSTLGLILSLAMAGVVTQFTKITVGRPRPDIIDRCQPRAGSVDPTFGLSTAAVCTQTDMSLLKDGFRSFPSGHSSLSFAGLGFLAFYLAGKLHLFDHKGYLGKVWLFLAPLSGATLVAISRTMDYRHHWQDVLVGSILGTVMAYFSYRQYYPSLSSELCHKPYSPRIAREPEILPMHHRHQHSETSALPPPDGTVPRSDPGSLTELWGTNARNETSEYHSESRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4M2</accession>
    <name>A0AA38N4M2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1052987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4M2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041325965" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10306" checksum="6F69BEF0DBA92CEE" modified="2024-01-24" version="1">MLLLQLFWAVPLTQHSPHFVPLMSKTFHQRMRSHRTLFSNLQCPVRLPKVVDRSLLQRLIVLNSSFLLKCVTSGHWRKVSTMYSFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N509</accession>
    <name>A0AA38N509_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1129568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N509"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="23904" checksum="65AA65FAEE41240D" modified="2024-01-24" version="1">MSTFMSWFGARRDPKQSARDAIVGLRQQLQMIEKKEEYLQKKIDEELRKAKANAVTNKAVATAALKRKKASEAELDRLAGTRLQLEMQVNTLESANLNAETMAAMKKAADALKVIHGNMTVDQVDATMNEVTQQREVAQEIADIISNPTPMADLDEDELLQELNDLEQEQLDERLQGAEHVPLHQPQIVKEPEPEAVDEEEELRQLRASMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N567</accession>
    <name>A0AA38N567_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_23028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N567"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041321270" evidence="2">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="265" mass="27990" checksum="E9460CCC928A4744" modified="2024-01-24" version="1">MKLTAFFISIALTFSVATASSSDFSAHLAARESRISRPFTKSTNATDNGPLDGSTTEDLYSTNWAGGLLESPPVGQRFIDVGGTFVVPTLRGNDGAMSVWIGIDGGPNAPQSILQTGIDCYIIGGVNYFFAWFEWYPQDGFEITNFVVAAQNTITLRVQAVNSTTGIITLTNESTGQSGSLEVTAPDVDAALQGQTAEWIVEDLEQDGALVPLPSFGQVQFTDAAAFTGVVEDFASVGVAVDMVQNGGFVATSTINQNIVTVDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5T8</accession>
    <name>A0AA38N5T8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1035608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5T8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041454579" description="Origin recognition complex subunit 2" evidence="7">
        <location>
            <begin position="19"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="8">
        <location>
            <begin position="264"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="9">
        <location>
            <begin position="517"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="589" mass="64595" checksum="26569070618890D8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5U7</accession>
    <name>A0AA38N5U7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1048034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5U7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="76" mass="9081" checksum="77655543FDB9B07C" modified="2024-01-24" version="1">MTEHFYFRNHLCIAMELLSINLYELIKANGFVGFTTALIRRFTSQMLMSLTLMRHHRIVHLSNFRMFFCATLQRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N655</accession>
    <name>A0AA38N655_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_987251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N655"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="155"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3737838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="341" mass="36346" checksum="676608EB155A4F96" modified="2024-01-24" version="1" fragment="single">QYALIFLPGLVTGRMFDIGIFRIPSAVASVILVATSILTGQCTEYWQFLLCQGIALGLACGTLFGPSMGILGHWFKKKRGLALGINACGSSLGGTVIPIATRRLLVEVGFPWTMRILGFIMLFVLAFPNLLLARRLPPKRISGGMFHFAAFKSAPYSVYCISSLIAFLGLYTVLTYIDISASAAGIDEDFSFYLVSIANAASGFGRLSSGIACDKIGGINFMAPMTLVAAALTYAWPFAKTKAGFVVVAIIYGFASGVYVSCFLMPIYEMSDVHDIGRRTGMIMTIGAVGALLGPPISGAINANTGGYTAVGYYAGSMIVVASALMVLTRQLYLKKIWGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1E0</accession>
    <name>A0AA38J1E0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154481</name>
        <name evidence="1" type="ORF">DFJ43DRAFT_1161875</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000123">
        <property type="protein sequence ID" value="KAJ3711136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1E0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53468" checksum="C35928A25DBEB0BC" modified="2024-01-24" version="1">MSSKCNGCGKTFLGASFLHHLRKTSNSDCQDYGQSIGACPVDSQTAQLLTSLLQGTSSESSNISMEEQQSTGTQMPIIVDPSGDYFGDYYNCLDLDINMGDDDPAIEVAVSSLGADSEDGSLDYDFEDDDLDSRGRSPQLIFPDGFFDEPWQLPHSRVPAVVESLYLRAPHVEQYPDNHAGAPVESQNATADENTQYYHNLKVTVMNPWAPFESEIDWNIACWAKTRGPSSTALTELLAIDGVCDKHGLSFRTASQLNAIIDHKLPSIRPKFKRREVVVQNQAFEMYFRDVLECVKVLYGDAEFAEYLKYAPERHFNDRQFEEQLFHDMHTGGWWWSTQAKLDKHAGPGRTVIPIILSSDKTQVTLFRNKSVYPVYMTIGNIPKELRRKPSYRAYVLVGYLPTTRLEHIKNAASCRQSLANLFHTCMRTIVQPLEDAGATGLVIASGDGVKRHGHPIFAAHVGDYPEQILVACCITGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2U6</accession>
    <name>A0AA38J2U6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1160738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000089">
        <property type="protein sequence ID" value="KAJ3714662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2U6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="875" mass="100328" checksum="DA2C3540E4179F02" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3H5</accession>
    <name>A0AA38J3H5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1100627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3H5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041438927" evidence="1">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="183" mass="20402" checksum="FB8C82A1442F5407" modified="2024-01-24" version="1">MSPVFLHKLAILVCLGLLSLSRAGPVKAKNNECSSRSPPFDPKMPMGYAYYNTGKGKYVSHSEKYPIRIHSVPKPPHAGHLKCLVYDKKGYFSNPDLRLLYVPEGDLFTQNTAVNYVIKQGMKPKSTIMVSVSSTTNLLDTMVIPRHMEDVVEIDCPTEEEQESSIVAHMDSSWKCLTIVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3W9</accession>
    <name>A0AA38J3W9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1134285</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="226"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="422"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="554"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="703"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1081"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1303"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="876"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1265"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1437"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="923"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1273"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1437"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3718573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1476" mass="161541" checksum="C76B506EF9B4D85E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3Y6</accession>
    <name>A0AA38J3Y6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1042890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3Y6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12830" checksum="B8C6840B7692046C" modified="2024-01-24" version="1">MAEIGALGDVWPSARVQICYWHQRKAIKERIEKVKLSTTPYNANRAHAEFLFIDKNWVPPGHADPDEHEGGREGGGRDTVIDDPPMQPKRDPNMITFHLPALKHDHATIQLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J479</accession>
    <name>A0AA38J479_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1007113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000082">
        <property type="protein sequence ID" value="KAJ3715921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J479"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="60"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3715921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="380" mass="43251" checksum="5EFF6C30A9B548B3" modified="2024-01-24" version="1">MLSSRLPSCSSGRRFRNLYPCYRSYSSPPTPQHSIYISKSTNPYFNLSFEDWFVLFRHKAPDKPLLLLYRDDSCVVIGRNQNPWKEVNLSALRAREGIPFIRRRSGGGTVYHDLGNTNFSIHLPRTSFDRHLTAQVVLRAVRSLGIDATVNDRNDICVGKEKICWSAYKIVSQRAYHHGTMLISTQLDTLGDLLHNTKDTMETKGVASVRSPVRNLQQFKPTVTHEAFVDAVIHEFREEYEVRAVNDIIGEDNCKDIEYIQDGMLELPSWDWAYGQTPEFTYTVSQAFEWGTVKAKIRSKHGLILDCDLSVSNTDSQVVSMSAVLQDCVNSTDSRLKEVERALQGRKYGFVSAMDILNGNKTGTRVKKDVAFWLESMMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4L1</accession>
    <name>A0AA38J4L1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn finger family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1203402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4L1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="412"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3721358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="662" mass="72358" checksum="034C9707122B6626" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6P7</accession>
    <name>A0AA38J6P7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1001563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6P7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="53"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3728037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="928" mass="101111" checksum="323ADCBBDF6DEC96" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J726</accession>
    <name>A0AA38J726_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1090825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J726"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3724210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="364" mass="40978" checksum="EBB532DC76DCED75" modified="2024-01-24" version="1">MFALPDYGENTVPPARYMPSSRLDAICMHRMQKLMADSYIEGRKYWAENPDAAPNEAQLEVEKFLEFTALLPKRTRPSEIEPVLIVSDEEDSSALTSTSEQGFPRPPKIRPRWMRYLSFSSNVSSFPKAPSPSRSRLMSLPLIGKIQRPSFPPKRLRRFSRAITSPVLRRTASEPSKPSTQSKSTPAPKTRRMTLDESEIALASSRTGGTDTNTSAQPISLPSSLCVARTPRFPCDYLPKASPTPTRKRRRRANTQDEKPQNFPKQSLAIILPPQPLVILERYPPFGSPNCVRKVPLPPPEWFDTPFPEEEKPAAEVPAGQQEEEEALTWYNILLAPFALAALFVIIPVFLIIYLLSSLFDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7F4</accession>
    <name>A0AA38J7F4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1083370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7F4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041460159" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="47183" checksum="62AB3DB374C47DD2" modified="2024-01-24" version="1">MVQFTDALVFALLSATARAAPLLLNKRIAQTTIDSVTPWEDACSSAGGGQQCNPIAVTAASTLLAAAGNCDQQDSADAMISLAKTLNNDANMISLAQIFAQQPRNSPNSLAVPYCDTAPQNSELNGFFQCQFQGSDQTSFVGGLSVGEAGTIPLGLSAAVSPAGSCPANPNGPVADGQQLNAITQNPGTPSSSGSTASGSTSVSSGSTASSAAPATASSSASTSDNSGAGAAAGDSASSASSSTSTAGTTTSSTTSSTSGFALSNGQAAQAQNAQFASLTAGSSCTDGQNACVNGAFAQCVGGKFETTQCGSGETCAALPLVNSAGTSITCTTTADAEARIAATGATGGLTGDGSTASDSSASSDTSASAAVSSSTAAASSTSATASDNQAATSSSSTSSFALSNGQAAQKLNAQFATLSASSTCTDGENACVNGAFAQCVSGKFETTACAGGTTCAALPLVNSAGTSITCATTADAEARIAATGATGGLTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7T1</accession>
    <name>A0AA38J7T1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1101595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000082">
        <property type="protein sequence ID" value="KAJ3715886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7T1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041268821" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31073" checksum="9A9AEA4A280D0B7A" modified="2024-01-24" version="1">MQKIHFIPFFILAMSITAAQSAPVVQLPENSVTSDPSRNIEPPHFENFVSLSRRTIGVQSLVKDGTLREFGKFNPVPTVKEVSEFFIHNLDIVLGPAVEGGTNNKAVTNLAGPDDYKGHPKNKLFVKVLFSKAIDTYDEARALEMMGLLVDTGLVQLKDHKGTLTPPYPAIIMKKKEGVLLLESQEYQAANEAEQRRMKIETVTLICEQAAKDAVQYKVYHDDNKPENAFITFAKGSVKAVDIFDYGHPDTYEVMKEVGEQKLSELCKAHWVRKYSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7Z3</accession>
    <name>A0AA38J7Z3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate esterase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1007670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7Z3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31611" checksum="04F60DA20F8DF18B" modified="2024-01-24" version="1">MQHVSQNDTAANGGVQWPWYLGLYGNYTIWNYAVGGAVCSNNLTPLYGEPDVSTGQQAWFIQDHIDAYKTSHQKLSLDPSSFVVVQFIGTNDVGIGSFLTTDEAANVSLPDVADCQLNSLKSMHALGARNFILNSLIPLQLTGLYSNSSAPTIYYPEVHDGNAWNKGMYNLVHSLNRMLSDGIDVLNVEWAGDGRIEWFNTYDFFKTMYNNPTQYFNGSIPANVTGHCHQCPDPDDYTQCGIGDCTLAERDSYMWWDELHPSEQTGRNLAAEIYKKIEGKSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J810</accession>
    <name>A0AA38J810_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1126860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000081">
        <property type="protein sequence ID" value="KAJ3715961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J810"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="100"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3715961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="821" mass="91953" checksum="1B5135F38DF3135E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9K6</accession>
    <name>A0AA38J9K6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_348724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9K6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="422"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="678" mass="73767" checksum="8B1C24D650B61EC1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA21</accession>
    <name>A0AA38JA21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_312495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA21"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="315" mass="36224" checksum="81C26F99E686D5BF" modified="2024-01-24" version="1">MSPSAWIPDISCSSPLSSESSFDEDEVNYRMKPYWPKYRIIIKNLGFRLETVRDVKAYYKLIGMPEQAEQLKGLVEDALCPDAGLPDNLFRGTRIADGSKIMVKAVHRRSRELEIIRFLSSPAMRRHPMNHCIPVHDLIEVAEDNIAFIVMEQWSSQLIINDAPCCLRLFLAAIRSCVEHCLFMHRHHIAHLDISLRNLLTDYKGHYAYIDFELSRRVDISDPRVFGRRGTEVPPEYGHDTFCDPYKVDVWALGILILRACKLAGFCIPELIEIVKPMLHEDPAQRPSIETVLHTYNLMTSSLSPERLLMLPDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA58</accession>
    <name>A0AA38JA58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_964792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA58"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3721445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21758" checksum="B686F6F147D8D667" modified="2024-01-24" version="1" fragment="single">SGRKVVLVDTPGFDDSRDGRTDTEILRKISEFMISEYDQHRKLNGSIFFHRMSDPRFGGQSRRSLRIFRELCGAATFKNVVVLTTFWDRVNEQEGLAREEELKSNSNFFKDLVDGGARFIRHDRENNGARQVLDHIFTLVPTTVQIQKEIWEEGKSLEEIAAGSAQREEINRMVAKHKKEMDDLNIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAC3</accession>
    <name>A0AA38JAC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1079569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAC3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3731304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="468" mass="51197" checksum="EF793282734BB19C" modified="2024-01-24" version="1">MNVALPCLIFSNIVPAFTPSNISAIGPLMLLAVIYILVGFVSGLIIREICFVPRNFWQGIIICAGMSNWGNLPTSVVQSVTAHAPFNGTTDVELGVSFVSIFIMVYHIFFWVFGAAASLQWDFLPDVPQGEEANKRVRWNAKPIGGLVYRVFRLHFQTEDGKGRNPTEFLGRMKRLIVNEDKSSLKKSESLDEKKCEQDVFPCPDLLEAGAAEPYREESIDPDVQLARRVSRLSSSAPFQPQLLSNSASLIHSHDSSETTLPLAHNTPKWERFFPSWFVRTFKSISVIITPVTIALAISLPVSVIQPLKALFTDATASGGPDWTGPDGSPPLNFIMDTATFIGELCVPLSLIILGASFARMSIPKRLSTLPIPAMILVMLSKEVLVPVIGIFLTQAFVAKGLIPKENLAQRFVAIFLSGTPTAVNQLVVANLYAPEGGMDTLTAFLVVQYTFMFFSSTALTAIALLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAD0</accession>
    <name>A0AA38JAD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1155555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAD0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="14">
        <location>
            <begin position="312"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="14">
        <location>
            <begin position="803"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="197"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="347"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="637"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="853"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1063"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="355"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="699"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3731319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1121" mass="119388" checksum="14BF3299BA6953F0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAE0</accession>
    <name>A0AA38JAE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1097500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAE0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3719146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="156" mass="17144" checksum="E7B840965A038CCE" modified="2024-01-24" version="1">MQLEEQNQLNCSANPESDLSQYLAFPFESDANFKKGLSDIASLTGSSSDIPEDTLRSMRVFYFNRMTGHSLSVADVQAYESNRNSTEDILTSTSNTPGNADVESSSVESFSFAQIQALIEAGKFDEIPNNKTISTALNSTSPDRSTVSPRKKPWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB02</accession>
    <name>A0AA38JB02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1101276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000080">
        <property type="protein sequence ID" value="KAJ3716232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB02"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="272" mass="29405" checksum="1060C951ACC7CCE1" modified="2024-01-24" version="1">MYAFNAVAKAAGGAHSDEEYDKLLPLPSRSASRNLKNDLCGGKSTSVPIPESGWVEYLCGELVGKAPTLVGSPTLEETAEGRGIVHLRKSFSKDGSLPFPGTINSASTCYSSSFGAGMELDSNRGNDHEFLPLPSLQPSMDRSRQTSMNSYQSTAALVVRKKNTSIRSTGTMRSSTNGLYRNFESQRRPRYAYGGVMTVGSRRGSVASKAPKLPALPSFSRSKSGSRTSSLSRLSTMRSMKSTRSIITVLTDREEMARKALIERQRKGSAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB76</accession>
    <name>A0AA38JB76_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1197298</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB76"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3725052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="285" mass="31041" checksum="45649C78F0841968" modified="2024-01-24" version="1">MPATRRKTASSARGSDGPFKCPQCDTYTTRKADLKRHEQIHSDAKHKCPHRSEGCMFSTRQKSNLKTHLAQHFARAPFEVSPPTVPDVAGSTLAPSDSHRAERSPRIDRAAVVDRSHPSSAFQTSKPSKPAHTGNFDAPAAPAIPPPPYDCSDQLPLEKLHYPLVEYPYPSEDPSRLESLWQTPHSGRLEFSQQPRNLIGSRMGMNFANFEVVAAGNFGQGMASNLVMGMGMNVNGRLTPITPVPALPTMSTHGGYSLAYGYSNPVTGSTVEAVPTSINGIQRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBH2</accession>
    <name>A0AA38JBH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1137933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBH2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="199"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="462" mass="52693" checksum="C6BF65C0DEBF945D" modified="2024-01-24" version="1">MSEPDVDLEFGYSLSFPLPFRVFALTSLGILAWATNLHGLDNFGVDAVSALDLRIGDHYSPSQRYWPDSPRKTDVTVLYKNVYRIFITYTVWCLLSWTMFRSLSQGDPALVDVFGYIPAVFALVTVLILLLPFNVLFKSERDKFLHAIRRCISSPPGSPIYFADVVFADVFTSLAKVLGDVFISLRMLLPGNSLLEPPADHGWTRWIMPTIMSIPYLVRFRQCVIEWLSADNTSRRPLANAVKYATAFPVMYLSAAQRLVVSDLINEKGKQAADEAWHGEHPLFRLWLLFAAINSLYSFWWDVTNDWGLELLKPGSKASGRPLPPRRLVLPHLHSGTALLGSHRPAEEVEERATYPFGLRPTLLYPLPVYPLLVFLNLVLRLTWSIKLSSHLHSKSEGSVAIFLIEVAEIFRRWMWVFVRVEWEVIKKARESRNTGRTSLSDTDEPDFEMITTPTMEHNIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC06</accession>
    <name>A0AA38JC06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_558461</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="11">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="92"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3726502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="367" mass="38954" checksum="4E7DEA3D129911C8" modified="2024-01-24" version="1">MTLNPVYEATSFKVIIRKLVDTPEAFTPDDLRVAFDDLLAPDLLPPEQIGALLTALHIHHIERRPELLVTAASVLRERALAVVVEGAEEDFVVDIVGTGGDGHNLFNVSTAAGIVAAGAGARVIKHGNKASTSSSGSADLLQALGCDFHRGACNGQIIPRMPFAFILASQYHPTLATIGPHRKALPFRTIFNVLGPLISPAQPKGMVLGVPQPELGLPFAKALRDSGVLRALIVCGQEGIDEISCAGPTRVWELQDGRISESTLCPETFGLKSCSLEVVAGGSPETNAATLEILLRSGENIPRSKRPFLDFVLMNASALLVVSGLADTYTNGVKMAYEAVVSGQAWHVLEGFRDSLGYLGHAHTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCK5</accession>
    <name>A0AA38JCK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IQ calmodulin-binding motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_311947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCK5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="750" mass="82560" checksum="1C3599600BA0D833" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCN9</accession>
    <name>A0AA38JCN9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1093017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCN9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="313" mass="34378" checksum="9914725A3B231B5E" modified="2024-01-24" version="1">MFNSRPPTGAQPSYVSRISAGRSLRSIVMLFAFLSALYSLFSYIGNFRSISIDRGQNESKLATFSLVLGILYITVFAFEQRHQLVRVYAMLSFATVLIATGGGLLDVIVHFTMKNDIIDECTNLVTGDDVVYYPFGFFGPVSHSVIDQADARSWCQSEWDHDSWADIVELLILIFLSMMFALFSYAYYRQLLDPTSAANVVRTPIRAPPSGFPSHYNPAYNASVPSLGYQYGPYGQQPYGQFAPPPGPPPAMEGADGKLPAYTGGPGYGYEIDDKAKENPFADFDEPAFKAGGSQEEHDVTSRPGPGGRDTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD48</accession>
    <name>A0AA38JD48_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1106381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000109">
        <property type="protein sequence ID" value="KAJ3712356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD48"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3712356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="367" mass="42864" checksum="EDD2F109D7D0011F" modified="2024-01-24" version="1">MNVSVVGRKKFLTILLSLVGAFCIRLLIPFTSSAFSSTSDQDFSYNTNAPLPTGRGTANATLVFLARNSDLSGVISSMQHLEEKFNKEYGYPWVFLNEEPFSDDFKTAVQKESSAPISFGLIPSKDWYQPDWIDEERATEGRDKMKAANIIYADNVPYRNMCRFNSGFFYKHPLLQPYRYYWRVEPDIKYFCDVTYDPFDYLRDNKKTYGFTISFYEWEKTIPTLWATVKEFMALHPEHIASENAMNYLSDNGGDTYNLCHFWSNFEIADMDFWRSEAYTSFFDFLDSKGGFYYERWGDAPVHSIAAALFLPKSQLHFFRDIGYRHEPFQHCPKGDDWVRGMCTCNSYDTLDYAPQSCISRYEKMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD62</accession>
    <name>A0AA38JD62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lish motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1222287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD62"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="245" mass="27717" checksum="648B8E11C116EFBF" modified="2024-01-24" version="1">MPTAPPKEQIYKEEWDRRLHEVQISKSDLNRLIMDYLVIEGYKSAAEEFAQEASVASEVDFESIESRMKVREALQRGDVEDAIVRVNELNPEILDNNRALFFHLQQQKLIEYIRQGQVVDALQFAQDELAQLGEHSPEFLSELERTMSLLAFVHSSSTPSAISDLLSPAQRMKTAGEVNAAILESLSQGKEVKLVQLVKLLSWGQGMLNERAAFPKMTLDDGSILGLVLLLFGYNGKFYTQERQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDP0</accession>
    <name>A0AA38JDP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_884426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000093">
        <property type="protein sequence ID" value="KAJ3714000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDP0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3714000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="141" mass="15631" checksum="B35E5B8A1B1BD4BB" modified="2024-01-24" version="1">MSQSDDKCLFCMIVKGTIPSFKVYETEHSLAFLDISPVSEGHTQVIPKYHAVTIADLPDEYLADIGPVVKKVALATGASAYNVLQNNGKIAFQHVDHVHYHVIPKTSEKDGLILDIDVSWPQKKAEKEELAATLEKMKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE30</accession>
    <name>A0AA38JE30_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1160451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE30"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3715583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="153" mass="17251" checksum="4CD5256AA2321CA4" modified="2024-01-24" version="1">MSLALIEQMNRLRLDEDGTAPLNDSNATGQLTSVGQTEIKPFLPIDLASRTTPLSCMPHVRDEHNWIICYLDEESSTPLNVDSFTSHWRPSLNGPSNLVPPDCQWIAINRGRSYDPCPQRINELNAAFKTLSRSHLRDGYITLTVSVLQFQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEH2</accession>
    <name>A0AA38JEH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_991284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEH2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="497" mass="55642" checksum="CBCC959CA242E666" modified="2024-01-24" version="1">MLDLKYLDAVVGSFAVLCVYRLMTLEKRALPLPPGPRGWPIIGNLLDVPAKEEWFTFAKWGETYVLGQPLIILNSASIAKDMLEKNSAIYSDRPVIPMGGELCGWKNTLVLTPYGERFRNYRRLAHQLFGNAATMKSFHPVEELETHRFLKRLLSRPAEFSDHIRKTAGAIILRISHGYEVGEGQDPFVTLADKATEQFALSTAPGFLVNLVPFLQYLPDWFPGASFKKTAKEWSSTLNEMVDLPYDYVKKQIVSGTAEPSYVSKLVEGQSLTAEQEFEIKWSSASLYSGGADTTVSAIYSFFKAMALYPEVQAKAQAELDAVVGNDRLPSFEDRDHLPYMQAVTLETLRWFSVVPTSVPHRVTEDNVFKGYFIPKGALVLSNLWQMNHDPEVYHDPMSFKPERFLGPNPELDPREACFGFGRRICPGRVLADASVFISCAMALAVFNISKYSENGVVIEPDRNQSSGTISHPSSFKCTISPRSDKAVALIQADERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JET9</accession>
    <name>A0AA38JET9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pex19 protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1207400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JET9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="318" mass="34554" checksum="0F1B29918F5E033A" modified="2024-01-24" version="1">MALSSFSLWEKGTIPAVHRSHTRNFVRSLRNLDRNPFRLHGLNNSQRQTIEGPEDTDDHPEGPEHEAALSDVFTTELMKNMQDLMRELADEKSTEMGSGEEANEAGTEGEAERLMKAAWEAMLIEGMNGMTETGTETAPSTSAAALISTSSATGSDFQNKIKQTMEKLKESEDNIQNLSSSTSSSNPESLQGLLNSLKDLGLDDLGASGDGEEDEAKLASFLESMMGQLMNKEVLYEPLKELNEKFPPFLTNPPSVLSPADQTRYEKQHDCVKQGGSDAAKVVDLMGELQTYGNPPESIIGSVPPELMGPDGGQCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEV2</accession>
    <name>A0AA38JEV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1161252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000102">
        <property type="protein sequence ID" value="KAJ3713039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="125"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3713039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="452" mass="49942" checksum="A504D291400EE818" modified="2024-01-24" version="1">MNASIIANPTAKRASSVHNVNSLDPPFGSRYLVDSSLTFTQNAWDHVPPPVDQGATIAASLARQRAAVVSEEEKLKINSKPAKYWDNFYKNNEGNFFKDRKWLHNEFPDLVAAAEPTAGSLKIAEFGCGAGNSIFPVLSANKNPLLELYAYDYSSHAVKLVQHNPLYNSPSCGSIHAAVWDLASDHLLPPGLVPGSVDIVILVFVLSALHPDEWASAIRNVQKVLKPGTGKVLFRDYGRYDLTQLRFKSGRMMSDNFYKRGDGTRVYFFELDELSLLFTGKRLSKEEKDIANSGADTTQMVEDEEDLGTGSTSEIPSTPSNVPTTIDEIDGSSPAATDPRNATAILRPIQQSGMLFPSDISTARIDSLSPNRGDLDIHPKLLDPLFDGTGDSNKSDGQHLMPHHPLFSTINLGIDRRLIVNRKRQLKMYRVWMQGVFQKNQGSIMKQRASEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF71</accession>
    <name>A0AA38JF71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DFJ43DRAFT_1062063</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF71"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3734891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="662" mass="72298" checksum="15DB466547CA3DC4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF76</accession>
    <name>A0AA38JF76_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1104560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000094">
        <property type="protein sequence ID" value="KAJ3713987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF76"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041404496" evidence="1">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="217" mass="24358" checksum="A52BD02875EBE2A5" modified="2024-01-24" version="1">MIISAKFCSLKIEAWLLLVLSFLSVARTMPAPLTFPYNEDFRDATNQLSNTDFVEHSTLEPKILVPRDSLMTAVVQYDKKGQKVTSEDGYHVGMAVSKLLDVFANTWKTLGGRPMKNGDMFYFHFSLSDSGSRLNRRYIGRVILKQNGQNDLFFDGHIMNGEEKTLVVSAYNIPLVRKACTTSLALILISPAGKIYQVVISTPATASRLWSDHSLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFJ7</accession>
    <name>A0AA38JFJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiamine pyrophosphate enzyme, N-terminal TPP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_558463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFJ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3726503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="672" mass="72735" checksum="DCDCD1C7958E5258" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFV0</accession>
    <name>A0AA38JFV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1081954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFV0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041480065" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="30"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3730917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="524" mass="56580" checksum="E800E2DAF04C5B62" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGP9</accession>
    <name>A0AA38JGP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1210611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGP9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3716325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="275" mass="30370" checksum="92822B1479AFB164" modified="2024-01-24" version="1">MASFLRQTYGHRIQNHSNPTARLLLETMERKKSNLAVSVDVTRSKDFLAIIDAVGPFVCLTHIDILEDFDHSLIQQLQDLSVKHDFVIFEDRKFADIGNTVALQYSSGVHKIASWSHITNAHPVPGPSIISGLSSVGLPLGRGLLLLAEMSTQGALAIGSYTEEAVRMARAHRDFVIGFIAQRNMQGVGMQADNVDKDDFLILTPGVGLDSKGDAMGQQYRTPRQVILESGCDVIIVGRGIYGKDPSLVDEIRQQAKRYMEAGWEAYEERVSTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGS4</accession>
    <name>A0AA38JGS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1049690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGS4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041339876" evidence="2">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="266" mass="29726" checksum="087B957F7D0C360D" modified="2024-01-24" version="1">MHLRSNTFFSTLFMSLLFIASTFAIPISRDSNSVSNPSAKLVDREVLPQSVDAQADASPTSKQSTQSPTQPVEAQVTIYASPLPEKDEAALKAGIENMFCSKKITSFFRTILVKFFKDTRPKADIKTLKNVNKIPVTAISYNTSVKPWRSSETPRYQFEFILTGKPAGPDSVFSSLDGWDFMGVIERASLSNGGKKPTGNFYAEDPDPRVRSFDKIAWVTKGKGKIRTGWTDRLECWQAEWVALKKMLGFAKNLPYLPRCPAHFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGZ9</accession>
    <name>A0AA38JGZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1061825</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGZ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="61"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3734829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="251" mass="28168" checksum="D38CC473D06A888A" modified="2024-01-24" version="1">MSSPAAIAAKAALTSIDLSGYDPVQSKLMDERCILVDEDDNALGAMDKKTCHLMENINKGLLHRAFSAFVFRPSDGKLLLQKRAPEKITFPNMWTNTCCSHPLDDFEAEKVEKDQLGVRVAASRKLEHELGIPQNQTPVDEFQYLTRIHYLAPSDGMWGEHEVDYILFITADVTVVPNENEICDHKYVDKAELQAMFEESGNSFTPWFKLIARDFLFGWWDELLARKGADGKVVAKSLSGIVDGSKVVKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHP3</accession>
    <name>A0AA38JHP3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1098748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHP3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3718028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="156" mass="17919" checksum="24162EC203A51914" modified="2024-01-24" version="1">MSVYFYEPSYSWDRLFDEAFRSRSSRHGQSHQSRSQALTDQPEMSRFLKPKMDLHEDQEKNLVTATFEFPGVNKEDVQLNMHNGRLTVAAETKVSQDREQDGYAVRERSFGKFSRTLQLPQGVKEEDIKASMEHGVLTVTFPKASAEQTPKTITIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHS7</accession>
    <name>A0AA38JHS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Man1-Src1p-C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1070796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHS7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HeH/LEM" evidence="9">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="400"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3733039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="825" mass="91350" checksum="3B718F37E6A2B078" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHV9</accession>
    <name>A0AA38JHV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1000291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHV9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="105"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="363" mass="41609" checksum="EF1EB6FD748E9F15" modified="2024-01-24" version="1">MEDSPKQTTTKILTEPAPGTKTGPIHEYDENQKEMMKQVKEYALSISLPSSDPYAKWERRWLDKPDTIPRYSRASKWHLNDAKKRIKNTLEWRREFKPELIVPDEVKIEDESGKIVINGFDKDGRPIIYMRPGRQNTETSPRQLRHLVWCLERAKDLMPPGQESLVIIVDYKTTTLRTNPPISVASKVLTILQHHYVETLGRAIVTNLPLLLNFFYKGISPFLDPVTRDKMRFNPNLLELVPSSQLEAEFGGEYEYEFNHEHYWQQIIETCGIAPDGTRVNEVIPELDNEEAGEPKQPISDQGRETEEEKEEGTEEEEEESNTSTPATAVDSLTPVTPVAEDVAKRVEEMSISMSTEAQMITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI23</accession>
    <name>A0AA38JI23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1128973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI23"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="319"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="437" mass="49165" checksum="DA44EF1ADE17324D" modified="2024-01-24" version="1">MSVSLVSNAYLDDASSKIRSKPVPWEGYQRAGLVTPEDLALIKRIDRQSKAKTESLLLSDGQTYALLYLRLLKKLQGLDTMQYILVLIADALADHDERIPLFSRTSGSDPELPYSPLTRALDMQDEFMQLKSAQILTVLLCAEPRPLGPSQLHHFLGTLATMVQSHSPNKHDVGVQCLEALLARPECRQAVWAIPGIIAGLVEILKHKQGPQMCYQVAFCFWLLTFEQNIAEEINKKFDIIPLLTNVAQNAVKEKVIRVIVATFRNLVSKAPSANLPAMLVAQLLPYAKNLCGRKWTDDDIVEDVQYLRDELAANFQSLTTYDEYTSELASGHLSWSPVHESDDFWKENATKLNEKDYGQLKTLLQLLGESQDPLVLAVAVHDIGQYVKHYERGKKIINDLGAKRRVMELMSHSDSDVRYRALVSVQQLVSQPWITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI94</accession>
    <name>A0AA38JI94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1159516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI94"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51982" checksum="6A4C2F7B2F0CF270" modified="2024-01-24" version="1">MDSDENLPTKIIQKLLWLRTLLKNLPSALPTPQRGEIPKYPFETFRPDAAHLQKTEDEVGTINEGFKSIFGWKTWTTGDGIIPIEERGKHRIGAVADLLERYLKKYKDSSGQPNAVLVKWVEDISTGCEKAIKKHGKELPDIPVDNQVLKRKHAKGKGDRDESRDEDTSDPMGKRRKLGSKFDDLCLVNSSRKVVAGPGRKESDIIKRLAIKYQHKITGDPYFGCVAEQCSWLQSGNASKPCVLKHATTPCKHLSDEDRNFAFSSSAGSSLGSRMSVIAASSETAAARSTDSQLSLKSGSVSLDFTQAGKEEWQTVLDFCIMKLICVQGIVPNILDSDEWREFIAVATKNKLKATPSDAFEERHISNEASHVHKATVELLKKEFNLTLTFDGGDTRGQDSVYTAHATTADRKTYFLHSYEGTDEHHDANWVKNFIFQSIDLVGPEHFAALCSDNTGEDGQAIKVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIC6</accession>
    <name>A0AA38JIC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1002710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIC6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041388212" description="Coenzyme Q-binding protein COQ10 START domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23917" checksum="2BE5FA8AF56A4602" modified="2024-01-24" version="1">MLLSPQRAFRGIILCIVSLNVYRTLAVSNSTTPPTNLPPAIPSVFTVEASIIIDAPIDTVWTILLDFPKYPDWNPFVRSQVVTDDFYIPTQDQKVAENLRLIITSQIPPLTPPVTASSLGNPLDEHITRENITHYQPEIYRVAWQDLSLDALIQAERWSALSVFVDQSGDVMTFYESREQYNGVLADTVQDLEGAGLVEGFQAQAATLKARAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIC8</accession>
    <name>A0AA38JIC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1225000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIC8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="420"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3731035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="538" mass="59468" checksum="B78CA094FB64E637" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIL3</accession>
    <name>A0AA38JIL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1154952</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIL3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3731878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="301" mass="33495" checksum="4191E37678382057" modified="2024-01-24" version="1">MQTPHRTPLRRISHGSLLRLSRSGAYPDAPHGLGFLEPAMSEFVDETEILQTNVEGLKHLSDTLATFNESFASWLYVMNMNALTVDWPQAPHDGSFMLAKRRAGTIAPYIARDLLISSIHFSEQNAIAAMEALQAKAQAKSMQPSTSEGSMNDQTTIIDAKDTFISNSNNDSGSAKATKRVVKIKKPKLTAKEKKERALELERIVAFLPLEFRGSDPVRLTNSVSQFPRRPLPQNLRRNMEAVIEGIWDAPNQTLKLPDLIKPPDLNQARANKCLIALVNRKIVQKDSSTGTVLYHWQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIX7</accession>
    <name>A0AA38JIX7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1018183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIX7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49551" checksum="72F5A33F75F1387B" modified="2024-01-24" version="1">MFSFNSYSRSKSSPSKALSLSGRTQIECMDRGLRSVNGAKHIIGLINSRRTVTKLFLGHNILSDDGCVLLFTFLSSPLGRKCPIAEISLNANSIGDRGLAAISAYLMDNTTLTELFLQDNLFTSDPKTVTQFAHAINQSHLRLLSLTTNRSLADDFCRLFLPALRSRYLHELHLSAIGLTYSSAPYIAEYITSTDRCQLHTLKCNGNHLTFRGVRMIIRAIERANFGLAAVELYANNILSGPDSEDTDDDVTGTGTTQGYNPNAWQDVEKLLKQVLGRNTHLKKETWKEALQLLVYSRAVLLSSKESLNDSSNTLAVPISGFRFNHFPIEIKLHVLSFLSPTLCSSQRARIFTYASSTSTLPPLLPPLASTSFARSAEPAVFSMCVPDPLVTMGFTTPSVWTVNNLGDRGCAPGKCMGRRSLLCHLEQRRMLWLEQVGCLAYDQTEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ34</accession>
    <name>A0AA38JJ34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1182670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ34"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="483" mass="53480" checksum="AF53AEE4908C797A" modified="2024-01-24" version="1">MAILGRMTLIFMAKPGQNILLGSITADSIVGTVVSIGFQRQQVQHHGIASPLPARRTSGVSPLQQEIHYHATGFSPSGSSFRQTLHTSPSQNLPSASLNVQTRRPFTHQNLENRPLIQPIYKQVEVGYPVDAQVLEEHQRTESHRRARSSARQTETTTVDSSFLHQSSIAVASRQGLASIQLLLNDPSPSSPDSSSAVSTTLSPIRVPNMDPTPQPKILGVTSDTIDPRNAQVDCSDSEPPTIEESPDRESNTSTSEASFSTPAIQPRMGTGERRLKRRTTDTAFVDAVRALSNHIDDEVKRMASEFKRSLLTVKKLMGLHRRFRERKAPSLYNALLHRLAQKRRACGNPLGKNFGGQHQALMEDEELQDILQNPSSPEAHEAIRELTEYQEAKFRGTRASAKANDNDIVKTWGKIANTYLLKSQSLSHRTSAATFGFVCSSKPGQNVTRQFFGNGPIEAFVSDSVAQYWARRHTEIMDQKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKS0</accession>
    <name>A0AA38JKS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Costars domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_986930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the costars family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKS0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032970">
        <property type="term" value="P:regulation of actin filament-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044302">
        <property type="entry name" value="Costars"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46334:SF1">
        <property type="entry name" value="COSTARS FAMILY PROTEIN ABRACL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Costars" evidence="2">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="81" mass="8893" checksum="0EC99DFE71EC815F" modified="2024-01-24" version="1" fragment="single">PVVNTSEEITILKDAIIEYGSVNSEGKHSVAYGTLFDKTANTLEALNGTLRAAKRQKKVAFDAELLMMPKDKDVQVVLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL70</accession>
    <name>A0AA38JL70_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1048072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL70"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="226" mass="25489" checksum="EA9BB811C8FB6A4E" modified="2024-01-24" version="1">MFFRGIRALFQFQRGISKQTLTMSQQPKVVSVTDLLPHEAKWITLKKIKYTDAEGHERLWEVAQRKTRKTSGIDAVAILAILKSRTNSFPPSTVVVEQYRPPIDRFIVELPAGLIDEGETPEQAAIRELEEETGYKADSVIESSPILVSDPGMTNANMKLVVLNVTLEDKLETPDQKLESGEFIVRRVIELRKLLEELKVYDSKGFILDARLHHLAAGYTMAINGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLB2</accession>
    <name>A0AA38JLB2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLB2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39788" checksum="FFC4B153A5D18705" modified="2024-01-24" version="1">MSSTPSRPNSPSDDEEKAEEIRLQQKREERIRREAERKAEEEEEAAAEARLAEIRRRKEEKKKREAEEKKRIEEEERKKREEEEKENKRKEEEEEARVREEERKKKEDEDRAMKESQRKAAEDRVAEETRAREEENRAKSVGALVRDSIARREEEKERGKKNCSSCDDSILVVGKKRKRIAMIPTSAGDPDDSDDGFEPEGDDDDDDDDEEPSPTPSPRKSSKCDRCTSKGVPCTLIGEGSASCHACRKAKVKCSLVGNKRIVRRSKRVKREDSKKEETPMASSSSLRIDALEESNRELSRRLLLMEDMVRFIVQTIRPIDANEESEEDRVKRTGDVKGKGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLH6</accession>
    <name>A0AA38JLH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1045830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLH6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56821" checksum="3E8E05B5232A11DA" modified="2024-01-24" version="1">MEFYLSQPDIGQELHKALHEAAPLECKPVISIPETRSRRRARLRLSNSLSPIHSLPYELLSLIFTEYCLMPIGPDKKMFPHSVITQVCSTWRQVAHSTPRLWSRFQASYGLDGLEVNGDKMFTWLSRSGEVPLDVAIRPKDHTFSPASNVLGCLGSFEHRIRILHLAIPLHALLPLCPSSSFPLLTALNIRLIRSDSTKNKVRAKDHKLLPSILHRSPRLTDLTFVGSELSEEMVPNILGLLLPVSQLKILQLIVAAEACHILMNPLAYLQILIGSCTSLVHCTLRCPQWMPGVAVPDITFPLLQTLDLLDWHDECESRFLNAITVPSLRHFRTNHTYHGGFVNDSFANDLINLQTRSSAPLRSFELVGMHELLVDDILSILSVFPTIQGLGLNHCELETVPLMRALEYREDEPLLVPELRAFSYKNAQLKPKGSDRYIADMVESRNLTGDDNEQTRPPNLHCISKLTLIFERQSLSQAVTKRLKNCGIDELVLDDKKKKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLU8</accession>
    <name>A0AA38JLU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-carboxymuconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_111122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLU8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="44653" checksum="037C14E3CAF49026" modified="2024-01-24" version="1">MIPSFGTRSAFLALLFSAGIQNVASTISISGHYKGKVKMYLNTTASSSSVGSAYFITNEPTGNYVVAADIGSDGQLTLRSAYATGGIGSHVVAAATGVTTGPDGLNSQGAISVNTASSMLATVNAGSHTVSLFKIDENDSANLTLIGEPISSGGHFPTSVAFNDAGDTLCALNGGSINGVSCFHVNQTSGLQVIPNTTRYLPLNQTTPATTGAGGTVGQVLFSADNTQLLASVKGLLPGPPALVGYIAIWDINQSDHSLSEDYMPITPPENGNNPFGFTRIAGENSAVIAADTNDGFTIFDFTDGSKSSSVDVNTLGAICWSSFSPKTGNYYMIDAGGAVFEVNIDSNLKGSVVQQYNSTNMVGLFDGEIASLQNNDFLYILAENFSTIEVMSLNGPGKAQQIQSLDVASTLMAAGIPISSSNQGMATFVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLY2</accession>
    <name>A0AA38JLY2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1059871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLY2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="500" mass="54650" checksum="7224CA2A7FEEDEC7" modified="2024-01-24" version="1">MPRSKLSKSHSVHGHDNSDNIEAIEFPSPPTSTIPSISPIHSSPLPSPSFELKQGSVPDTVIRPDAANDHETITPTIIVHGTDSELAILPAQKETTGSLSLIKSIAKKASMKRLRSISGTFHHHNHSRDSSDASLSSSNSLTSSTSSSSSYTTSATSTTSANPTNSTTSSSPTHHRTRLPSLPSFRRRTSRIRHGSEQSHDDDPSEDLAPDTYYDGYTVPPSQRSFEVLSRPRPRPSQIAVAAVTKDVKRDSHDSVTTPVPDHSVLCCRCGSEVRGDAALEGSEESLRSVDSDLDRLTTKDVHPRIGSVSKDGKPAACHDFPITPDGHGLTHDDSSSSLASSSNAIRATKVAMKDEEVLKQSVKMGMKEDTLVIEGTNQHASGNVVDSSSTTDIASIHSTPQYSKTTSIYPPSDEETLPPFLVGPYLLDEVAIPILSGNRPLSFFFCHFLWGSLWKEMWYALTRRLQIYVRRRISVFLTWWLSRVSLSFLRRTSRGPFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMB6</accession>
    <name>A0AA38JMB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_995135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMB6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="366" mass="40316" checksum="CE12E05E43068E6F" modified="2024-01-24" version="1">MSHSTTTTATYVLAKYSRSYPKSAQDTNSEWQHYTKPTLKLILDVKKSLTSGELESVFLRIIWSMEDSYAQDQSELTFENFDLLSFSSLTSRQTDRSQGGLPLKAVYRDSVVGIRYISASNGTFRRFQITFSSPTDASQFIDSISSVCPCKANSTPGAPANIPQVMHVPSMVPPNLQHPIAKPSIMNTSAHAAHTSAVPLSNMHPNVSLNQADLFSPIASTQRFSSYPTMHFQHPGAPYVAPGMPVSSSSQMLIDHRNQLPSSSPPLPPPSAQPTFQFNTSQTHSQSTSYTPTPTQSENPSEAESSEIGIQTTDRFVFALREATSLYDMPHHSLEKLVGDVVQEDGFIQLMESLSLMWKIRGYITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN13</accession>
    <name>A0AA38JN13_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1040839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN13"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="31805" checksum="4CB6114F0D2903E5" modified="2024-01-24" version="1">MQRQVLGSVLGGVGSIVSGVGSGINSAVSGVGAGVTSGLGDITSAILPSTTTTTSSSSSTITSTSTSSSLTSISSTTTSSSTSSSSVYFSSSTTSAPSSASNTSPSASIYTSTSDGVKETITAFVTSSASPSPTQSATGNSNGFLNNKPLEGFVFALCGLVAIVILVLVTTFALRRSRRKRMINEALSYEPTTTHGYVDDTERNITEKTRESYSSTGSSGSGLGPPYSVGPVATGPPGMGQQVAYGYERENPAYAPRSPNPAYDATRSYGPSYGIDRVPQAPVIFAPPAGVSQAALIQPGLLSTSARVPVPAMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNE0</accession>
    <name>A0AA38JNE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1083941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNE0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3729190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="306" mass="34300" checksum="E1FDB9445847E09B" modified="2024-01-24" version="1">MDVVITEDTFWMIENYAFISATTLWIADFIETLPTEINAIWQKKLTGASVLFLINRYLFLLSIIFGMVTGLPGNRKNEECDVITNIVGFLEILAIATTNVLFALRVYAIYNKNRIILGTCFVLIISRLVIDILQQITSQGTSSAGTQFQSFSACLTDITDTNVYFQVQFVIPFITLVYDIYIFGLTMRKTIDLGFKMKRQGQSSVAHVIVQDVVLLSAVIAAILDGAVLISEISSPIFNVLPNMLISRLMLNLRTFTTPGTGDTLTTRNIGAPLDGGSFNEEEEEEEEEEEEELNEVEIEMETIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNQ2</accession>
    <name>A0AA38JNQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mate-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1082022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNQ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3730928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="552" mass="60307" checksum="0488815E4F9C9317" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNT8</accession>
    <name>A0AA38JNT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_994792</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNT8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3733805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="323" mass="36063" checksum="723722D59A143976" modified="2024-01-24" version="1">MSSDVSAAQDKRNLHYIIRSGLAGGVAGCLAKTVVAPLDRVKILFQASNPDFQKYAGTWSGAFRAGSEIYQTSGARGLFQGHSVTLLRIFPYAAIKYMAYDQVHHYLMPTRHKETNLRRFLAGSLSGMISVFFTYPLEVFRVRLAFHTKYTGKANNSLLGSFKQIYHEQATDISRPTVNASHYFDRYPLLKFYRGFSATLIGMIPYAGVSFLSWGYLRARFIPPPNDAKIQSTPVADLAIGAVSGGIAQTASYPFEVIRRRMQVGGITQPDRWLRWGETVRAIWVPSGWRGFYVGLSIGYLKVIPMTAVSFTVWQGGKRFLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPT4</accession>
    <name>A0AA38JPT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1019524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1298" mass="146497" checksum="107DDBD44D9FCA51" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQJ6</accession>
    <name>A0AA38JQJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-dependent hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1060947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQJ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10627" checksum="8BA8E727A7709663" modified="2024-01-24" version="1">MLMLETDAPWCSMTGAHASKAHLNTLPAPLNDLYFPPSVKPEKFVLGKSVKGRNEPCSIGGVAWVIHQLHPELPYEDIVEKVWENTVAVFGLDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQR3</accession>
    <name>A0AA38JQR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_1057322</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQR3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="19">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3735403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="500" mass="56334" checksum="F7CB7C6AF8B0C3AE" modified="2024-01-24" version="1">MGCQFEMLDRPLVPAQFLFVLLLILHKAFVSALANVQLKPGELSFTHQHELLPRYGHSLSKNTPRAPVQSTIDNRINRISSQPPTKSNLDVKLKTRPTAIYRPRSLDVFHEERRIALHREKGRIRNQEQTWTLETMIDEGDVHTMEHDSDRVNVNWDIIYLDGPDVQNLQTLAQLARMSGNAYALGPTQKNWYELDRAWNVSFPFGYEDAEDGFRGHVFLSSDNSTIVLAIKGTTLQGPTSKKDKFNDNLLFSCCCARVDFSWVFRQVCDCYSGSWKCDNTCLSNALVEESLLYTVGLNLVNDLLALYPSANLWLVGHSLGGALASLLGSTFGLPAVAFESPGERLAALRLGLPIPTPPPAQQLPPESDVIPERILIPSLSPTTHIYHTADPIPQGTCTGPFSPCSQTGYALETRCHLGQSIVFDTVTELGWRVDLRKHPIREVVGLMEMWDQEEEVTNFREARRRQVPEAKEEVDCVDCFKWEFGEFKDKELEHPVCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQU9</accession>
    <name>A0AA38JQU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1017412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQU9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="212"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="450"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="519"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="602"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="988" mass="109549" checksum="C2BF4FAF14BB42BB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR39</accession>
    <name>A0AA38JR39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_961776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR39"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="74" mass="8600" checksum="671E4F8405DFAF49" modified="2024-01-24" version="1" fragment="single">LYATPGYWAQEYHTSKLSGAQWVQELLVGHPDRIYTELGMRVHVFTAFVFELRLCGLSDSRYVKLDEKAAIFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRT9</accession>
    <name>A0AA38JRT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_2989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRT9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041339226" evidence="2">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="111" mass="11783" checksum="7845E935D84FF553" modified="2024-01-24" version="1">MQFQLSAVFFLSHIIMLVAASPIPIASSVVARLPEPVDSPLAPMDVEARALGFIADSPLAPLDAEARGLSESTANVDPPLDVLFRTLEPDSIDAATTPQPQERGCGRWACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSH2</accession>
    <name>A0AA38JSH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_91717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSH2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="334" mass="37620" checksum="CAD07E72FD9BD17F" modified="2024-01-24" version="1">MEQYLRQVKRLPHTHLRQFFRIKASDDFRALVATPAHKSQLRDSKMKRISKDLRRIKLALTGRQDAFSYILDLAYGRRGKLRWELMEPLLAQANAPSLPDPMIRSVPSSRPPVYSPELSALLINTASRTNKPLELHQLKFPPTLSARADPTSDEARLLGLLSRRLELNTRRRYFAREWKKVYPPLDIAVKGNDGLLSTSVSDVENAGGRILGSQDQGLLPGVEDIVGPPTAGTPITRRERLLGIHQSTGNSSKQRHPSRWLRRRYQALLGRLPVLILNKGHKKPSYGVHLPLSSIALVGRNAAHRRPALDAPNLAWLEHANVLEKGKPKNTVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSW8</accession>
    <name>A0AA38JSW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1045773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSW8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="220"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33411" checksum="B8D71C46FA2510B8" modified="2024-01-24" version="1">MALPRTLSVIGAGQMGIGIALVASLRAKIPVVLLYDHDPSQITRGLGFMDKLLAKDVSKGKISENDAKAAKARITAIASSSASASSNDETNWARELGERGTDMVVEAASERLSIKEGIFRALARNLSKDAVLASNTSSISITKLAGAAVDGLVTSVSRASEEGKSCAGRVVGVHFFNPVPVMKLCEVIPGLQTSEATLEQAKAFAIACGKEVSTSKDVPGFVSNALLMPFLNEAIMCLESGTATRDDIDKTLRLGMGHPMGPLQLADFIGLDTCLAIQETLYEGTHDSKYRPSILLGRMVDAGWLGKKSGKGFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT01</accession>
    <name>A0AA38JT01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1058405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT01"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38344" checksum="48ACD24B7877E1ED" modified="2024-01-24" version="1">MFYTTTIPYLFALWTIGFTILVGAAPLAVRASMATGLQSSEDPQGPILTTNEGGQVRLSAPPLMTIPLSPPPPPPPPPPSPPSSNTSRPLSFVLPKWVTAPYPHSLKVGDMEVFNTILQGITLAKKHSAMGNNNAGVYSVASFDPTFAQLFPPSIAAQNIDPSRLLVKVLKHIDDDMVAEVKALKAVSQFVASGLLKLPTARSNELGKMKRGIRDGKVRRDAVNYSSSDDDSFELKPVIVMLKMPGKPLTHTPEFISEKNPETKRQMMSDTLTMMCDRVGKLALEHRFVHRDNIIGNILVINEGSKVVDVNIIDWGGKYLSSIKDDVTWDDLMGWCHNRWAVYVWEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU57</accession>
    <name>A0AA38JU57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_826272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU57"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="8">
        <location>
            <begin position="680"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3735696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="954" mass="108356" checksum="666CBE22BA8060FE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXJ5</accession>
    <name>A0AA38JXJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase III subunit Rpc25-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1047991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXJ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="7">
        <location>
            <begin position="87"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="233" mass="25888" checksum="3D099F32C04C3C86" modified="2024-01-24" version="1">MTSDMFNLAILKDTVAIHPSNFGLPPEQALIAELNKKYANRVLHDVGLCVSVFDLSEVGEGKVRYGDGFLWYKTVFRMVILRPFTSEVILGKVKSSDESSVRVSLGFFDDIYIPAIYLPQPSCFDPNERAHFWIPDSELTKPHELLDTPTAGRMYIDTGEVIRIRVEADEFYDDEPGPPKALEGVAVANEVRRAPYSIIASIAEQGLGPVSWWNGAGAEAEDAEMEDAEMEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1S7</accession>
    <name>A0AA38K1S7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1049596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1S7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.280.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="132"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3737183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="323" mass="35885" checksum="D41E7E70C1189EC0" modified="2024-01-24" version="1">MSSYEKQRLANIAKNKKLLEQLGLDRPFFEPVDEPRKPQATTKKRKAEKIEDDDSATPRKKSSRTADTSSDQENSTLRRSTRNRGKAIDYSAEIVSEDYIPDAFKAGIRKTKNTGPLGREDGKRVHNPKKFGSIPGIEVGTWWETRQGCSTDSIHAPWVAGISGSPNGAYSVALSGGYDDDVDEGYAFTYTGSGGRDLKGTKAAPKNLRTAPQSSDQSFENPFNAALKRSSETKKPVRVIRGFKSRSNYAPTEGYRYDGLYVVESAWMEKGLNPKGYLVCKYLFKRLPDQPPIPVRTSRTNKDDSKGAEPEDVTESSEVEDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MR77</accession>
    <name>A0AA38MR77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1006533</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MR77"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041408076" description="FAD/NAD(P)-binding domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3717223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61307" checksum="50D24043EDA3AEC7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRC4</accession>
    <name>A0AA38MRC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Imprinted and ancient</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1005997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRC4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11605">
        <property type="entry name" value="RWD_DRWD_ELF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF24">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="7">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3718064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="339" mass="37390" checksum="53F56499402FA999" modified="2024-01-24" version="1">MVSSRPSSPRNFESVDELIEQLLSTPDREVVGSELEVLKSIYGDEAIRSWKGFPTDDTIRFEVAIDFPAPYNDVTIRILISLLTTYPAESPPQLQLLSRYIGAFGVDSSLFGSVLRTFISTNGVEWTEGAVCVFDGLQNVLDRCVQWYEDHLSAQKAGELLREDALIAGQPTALDPALEQPELSHTSNVLETINLPSNIQIFEAESIVDRKSAFVGRACSITDPSQVPLILSYLSSDRQIARAAHPTINAWRCQVGKIVHQDNDDDGETAAGGRLSHLLQILELNNVLVVVTRYFGGIHLGPDRFKHINQAARNALEIGGFLDEADSPRKSNPRGGRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTL7</accession>
    <name>A0AA38MTL7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">DFJ43DRAFT_998100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3732014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTL7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="90"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="279"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3732014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="443" mass="50981" checksum="9C627C81B0B6A79A" modified="2024-01-24" version="1">MSSLLGRLIVNFVLLLISFIAYSSQIFVIWPWYGRVVSVELLVLLVPFNMLVGMLLWNYFFSVTVDPGRVPPGWRPDTHSDGYEVKKLTGRPRYCKMCESFKPPRTHHCRQCGHLMTITKDHHCPWINNCVGHYNYGHFVRFLFYIDLACSYHLAMMVRRVYHNLNINYWDSIPGIEFVFILLNFVACIPVLLSVGAFSIYHFNGISNNTTTIEGWEKDKVATMVRRGKIQDVKFPYNLGRRRNIESVLGPNPLLWCWPTQTPGNGLRYELTEGEGDAIQQAWPPDDPTQPYFEEPEGEFKLPQSPWTFENGGVNPDLQPYNTKLRQDSVTRRRKSRKGTGYSTLPPYHPDYQGSDVESDEDQASGSELSGDGEYISSGRIRRGSEGYEFQPTDREDMLRRYLGQIGETPGRYHRYIPQAESDSEDDNDVPLGKTKLHNDIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUA3</accession>
    <name>A0AA38MUA3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1008271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000102">
        <property type="protein sequence ID" value="KAJ3713032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUA3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3713032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="69" mass="7642" checksum="DBC876D05B879C36" modified="2024-01-24" version="1">MPSQESDRIASAQQTLDILYEMSQLLNTHLDKETLTTCVRMIESGVNPEALAAVIQELRRENAALVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUS1</accession>
    <name>A0AA38MUS1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1038400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUS1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41113" checksum="E9FB7820A04A4066" modified="2024-01-24" version="1">MSTAMQLMHSHSSCSCISQTNLQTSSEFYPNVELSPAEKAHVSHSLSDLQHLLDRHDFELARLRDVITFLSTSQEALARRMEDVKSLVAPINALPDEILAEILRMHFLTQMEEIRYRSYGRIRIPLGFTRVCKRWRGVALESPRIWADVTAFGDMHVPANEGLSEAIFVRDLMNMFLSRSRHASLKVKLGLSTSQLRTKSSSRIVAPLLLAQSMRWGEADVDVDLEGDDLIPDVLHDEGNRGVGYIVPGLHGAFPLLKRLALGGKFASSSQRWRWQESPDAIHTPPPAISVQNASLLTHLTLNLRAPLTSSEMARAIDVPWHQIRTLKCNYSFGNLESLLRLCTNVQEVEVNAVFRATSSYKSVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUY6</accession>
    <name>A0AA38MUY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1043747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUY6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="119"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="119"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3714535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="522" mass="57961" checksum="CC2FD4ED79F20DF9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWP2</accession>
    <name>A0AA38MWP2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1094831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWP2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3721366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="372" mass="41845" checksum="D06278536A1CE42E" modified="2024-01-24" version="1">MTRVPSMIISRNDLSVIEGYLVSDDDDSQSSSSNLPSCRMKPMNFSTIATPHLSLIRYSTLFSSLTHRLGPKLEIQVPDDLSSDMMSDPDLPFYRSLTMFKRIRVFANAVNDLTVPYVTAAMEEEDPFVDWEEKGLKVEYQPRYRPLITSYNLSSSTAHKSKTRHSKPLIPLPPFLVKPFPFKTPSYPSLFLLPSLVFVRFTRATGRSRLRISQLEKRFADRQSLSLMQALSDLERQVERRIEDAVVDAIDDPVGDPIATNTNSPGTSTPFDRERMSPSPSPPPPPNKESSKNAPLLTPLQRTICARLNTLPGLKKEIAFIDDSLNPTSQSTKRSRKTKAVLIPIRNSHAPIVSRDVRNFEHHRIGEGVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWX8</accession>
    <name>A0AA38MWX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1124168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWX8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3722813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="233" mass="26071" checksum="088E822190FA438D" modified="2024-01-24" version="1">MQRTLFIQSLRSFVSVRVIVQAQSASRISSLSLANGGPIRLKSTKAATQKTTPTTFSSASTTASEKPAYTPPTVSKTVEPLTWPAYLSIRRSKRRWQNFAAIPCSLLGLLGGATYFGSLDTDPMKPIFGIDPFMFYGICTTACMGVGYLVGPTLGAFLWRQLPSSKRYGSLIDKKDKEFYERIGKNRVDVTLQSPTSPVPDYYGERIGSLHEYRKWLRDQNKYRRKVIFDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXH7</accession>
    <name>A0AA38MXH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 7">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1111569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 7"/>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXH7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="145"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="210" mass="23482" checksum="B99A631DA00581FA" modified="2024-01-24" version="1">MLQALQNQKRVLRKSIHSVIHSLENIQEQSRAVTAKILLLPEFHSCTRVSCYLSMPSGELDTSEIVTTILESSDKSLFAPKISQNGTMELLKLDNQNDLDTLPSGKWGIREPSYESEAGSRLNAIDAGLDLILVPGVAFDRSMSRLGHGKGYYDRYIARYIASGKPRPLLGEHLKVGLGLRDQLLDTAVPVEEHDYKMDMIVTPDEVLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXU7</accession>
    <name>A0AA38MXU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trypsin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1129118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXU7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35774" checksum="8C6A864655577956" modified="2024-01-24" version="1">MLRTFRFTWLLPRPITRQYATVSQSPVDLGGPPVPEGAALDLTPSIPSPLDRQILKVASCSESPSLSELVHSYLSNSRHILNSSLLYESRPSALRKVNRGPSTANSPDVLLIAHCVQDGDEHKITVASGFALEAPSQREGESLILSCAHTLEEADSSNGSNFHSSSTSRRVNSGSFVISSEGNMYPVTDIVSSLPRSDLMIMTCKNPGVATLPVSPYPVHAGTPVLGHFRNLDGAWVGDSWSKWVRGTVLGYRDFAGRETQPGTYDALSHLLFSPLPTAGSSGGPIIDEETGAVIGVMLGTRMDNRVEGTRGWGIPSETIFEMFSLPGLEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY07</accession>
    <name>A0AA38MY07_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Indole-diterpene biosynthesis protein PaxU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1041491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3725695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35636" checksum="DBF3DD7E1411BFB6" modified="2024-01-24" version="1">MSMAGVSNSQMSLPATLKRAGLAPIGKGIYLSNRTSEASGSSSAASNPSKTPNIILVFGWMGANLPHIFKYTKVYQEMYPDATQIIVQSRPQFFWSSNRTRMNNLVPVAEVLEAHGCSGTKLGVAPTSEIDPPRILVHSFSNGGGIQMYTLGKLLRARSKSSSDFRGHKPRMSAMIIDSCPGNATLRGALRAFTASLPKNSPLRIPLIIFIILIYSFNSFKHRIFGVQPIFERLKRGLLRQGPEGGILPWMTEKTPRMYVCSKKDELVPFEEIEEHVKEAKGRGLNASIEIYDDTPHVAHARKYPERYWGAVKDLWAAAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYB6</accession>
    <name>A0AA38MYB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1226334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYB6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="639" mass="71164" checksum="33761D7CFF502B6A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYE2</accession>
    <name>A0AA38MYE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphoglucomutase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_987663</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYE2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="48"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="237"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="337"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3737414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="67025" checksum="F18204328F022614" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYE7</accession>
    <name>A0AA38MYE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sure-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1086048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYE7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3727294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="316" mass="32296" checksum="1BCEE5CFD602F23B" modified="2024-01-24" version="1">MLSKYPIPAISTPMNLLASGAALLIYIGIVRSTNIVLTNDDGWAVAMIRAQNSALLEAGYDVVLSAPAENESGTGSSTATPTTLTEPCEFDTCTTGSPPEGFNASDPRLNYVNAFPVDSVRFGIQTLSPTFFGGAPDFVVSGPNVGNNLGTATVDISGTVGAACEAAKEGIPSTAFSAAGLSQVSFTDLSNDNADTLAALVFSQLTVEFVNALLAAGPPFLPPGISVNVNYPSSTSSSCASPSDFSFILTRIAPSNSATDVETCGTDHLPGETAVVATTGCFASVSVMNATTKTDVDATTQAFVLNRLGDFLSCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYF7</accession>
    <name>A0AA38MYF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2OG-Fe(II) oxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1086406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYF7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="191"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3727339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="378" mass="43549" checksum="CCEE11143B6D11FC" modified="2024-01-24" version="1">MPALVNTSPPPALLSWTEPPVTSESLDWAPLTIIDLAKFDQPGRKQELANELKEAVKLWGFWTVINSGISQDQISRQLDIGYTFFKQPLAEKKKVTCNFAEGNYFGYREPYRLIGSSDVKENMEMLNLPKYTPHYESYPRHDLIQAYKDEIQPFHRLVWDNVIRKLFILFAIILELPEEYFVERHHYDKPSEDHLRYMIYHPRPAEEDAKIGGQWSAGHTDFGAMTLLFSQPVAALQIRTPSNEWKWVKHVPGGITCNAADTLSFLTKGYIKSTVHRVVRPPADQAHLERLGLFYFVRPGDDTPMVPAPSPVLIREGYLSEHEEKLGKEQDTDAVNGFEYVRARVKNVHSRNTRHVHDGRGAKEVFRVKNLEVQDFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYG0</accession>
    <name>A0AA38MYG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_985197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYG0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041460851" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="87" mass="9705" checksum="04F6AF88CC421EE0" modified="2024-01-24" version="1" fragment="single">MDNLFAIGFGLCLRLVITLISQDSPSSLKVTGTLVGLWEGIVLLHFTQKWPRSYDPYVAYGVRMFVDLMVTESVPRMVLVAIWTGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ42</accession>
    <name>A0AA38MZ42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ42"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="127" mass="14294" checksum="45B5DC39F47391E3" modified="2024-01-24" version="1">MTILEIVRLSAQDLGVGLLPLTTVALFMVLVALWIGRQGSTRASSTILCSYWLFLAAVETVKVVRLNVLDETIPNKASSPKYPASDQLLDNAVMVALYYIFFVFELFTIIKMREVNQPKPIILRDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N013</accession>
    <name>A0AA38N013_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1040150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N013"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="19190" checksum="F05B2D2676A9A22D" modified="2024-01-24" version="1">MLGPLLNGDLMPPDEEKVDGNTWGLYFARGASISERKRFPSYLRLSSHSRFIDVEDGFGFDTFGDNIYKIKVIVDDRRYFVAGTYDQSSRECNMALQSYGCSEKLKGDLVIFCLSKYQPERFLETFPRFKNAKEKQEVTCRILTSFCKTVKAHIEKKAELYHIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0F1</accession>
    <name>A0AA38N0F1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_998323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3732002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0F1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="518" mass="55987" checksum="C6DAFD47C9B5EB8D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1Q0</accession>
    <name>A0AA38N1Q0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_149895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1Q0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="348" mass="38023" checksum="C8E200D340C5D730" modified="2024-01-24" version="1">MTKILMTGVTGYIGGTVLTRFAQRPDFEDFDIRCIVRSPEKAEKIKSLFKNVAPIVGSHSDISLMTEASSKVDVVIAMADCDDVDAATGTLQGLKKRFEKTGSKPIFINTSGTGVLSDTAAGMYATDTIWDDANPEQMATLKPTQPHRPVDLKIVSADAEGYVNTYIILPPTIWGISRGHLFDSGISNKKSVQIPALIRASLDRGHAGMVGLGKNIWHNVEVHELSDLYSILFDAVLSPLPNLGHGREGYFFGANEEHTLYQVGKSISDVMFKMSKSKGGEPSTFTKEEVDKYFNGSSYLGSNSRCRSNRSKTLGWAPKKTTEDMLESIYPETELVIEIGALTASEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N214</accession>
    <name>A0AA38N214_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_133811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1392"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1399"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1440" mass="161114" checksum="82ACE77A3DEC6546" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N367</accession>
    <name>A0AA38N367_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_992742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N367"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="78" mass="8919" checksum="2481263805E61AA2" modified="2024-01-24" version="1">MLPSVLPSRPALSDTTTTREQLETSQSLAKVTTPQETAIFICALQDCHKLFPSRDRLIQHRRKEHGSDEDKDIITWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3F1</accession>
    <name>A0AA38N3F1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1061851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3F1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="134" mass="13833" checksum="CB986E2B261DD802" modified="2024-01-24" version="1">MLSFLLCKSKSNVPRIVARAASTSTSSPTTSNHIATPTSAGPTPSTPVVGTQAPNHASTWSTNQRTRPAAGSGPRFEQTAMQLQPNPLSAMAMIAEEPIRVVDGRKAVCDGGGGPLGHPKIYINLDQPGARACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4R4</accession>
    <name>A0AA38N4R4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_249902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4R4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041386563" evidence="1">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="157" mass="17670" checksum="FEDE77ADB5645CEE" modified="2024-01-24" version="1">MHVNPVYLILGVLSAAYAAPLDTGIDHLVTGQVNSYAETYIRARAPTQLEHNADRTVYVMFEGEHAVQMLDGSGPPDNVQNVIYFGLQKLFKGFRRVDWTVLFNNAFESPEDWPILELQIQGIGKCLYVWCKVEVTPQKEQLGNITIVRSASAKFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4S1</accession>
    <name>A0AA38N4S1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_990132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4S1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40552" checksum="D0B4C37C3EDD9FAA" modified="2024-01-24" version="1">MSDEPCTRIFLFSHLRTRSNLFMRLLETHPKVIAKLYPFKDAFMNGPECQNAISTKQGRATAIGKSMKEFEETFAHTTFQAGLDAMEKTIAEAESEIAVIKEHTCFMLDSNIINGNVYCDREDKPRPVIIDHRLDIQRYENKENGVPHHVQRTEFPLPNPTLLPDRIISTLQPVIIIRHPSYTFPSALRASSSYGANVFDPDFAIIASFRWQRVVFDFYREYCERGRKLSCGRGRWPVVVDGDKLMNDTKGQMTKFCQVVGLEESDIRYSWDPHYVKRNAVWDAFTKIAEESTGVIKTSVRIGFLLSVQPPNMVEARKKWESEWDTNVARKLMELVELAMDDYNFLLRHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N580</accession>
    <name>A0AA38N580_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_528076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N580"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="139" mass="15850" checksum="E401B2089841AE19" modified="2024-01-24" version="1">MASSGIGVHPGCLQDYQTLKLGKKLKYIIFKFSPDFKEIVTEKTSESDKYEDFLEDLPEDQCRFAVYDFHFQKEGAGQRNKVCFFLWNPDAATIKSRMLTASSKEALRKSFDGIHIDIQGSDLSEVSYENVLEKASKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5C7</accession>
    <name>A0AA38N5C7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1036061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5C7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="251" mass="28062" checksum="DAFF99F707B848F2" modified="2024-01-24" version="1">MSSVWGLSWAPAQPPPVVTMQLLNSLELHSGHSDTQTNQLLNSLLHGSSLPGISSHEQMQMGDAMVVDPSGDFFGDYDHLEEGDFDLGARCGNEDQDKDDLELDDEDEGYQIPSAVAAVAGVFLPRPAMLSRENYLALKKASDEFIQNQSSGARDIKEVMENARHWTELEVFDEKIRDGDKNAEKPWVILSNIFEQQIPQMPEVNCFNVDMEPEVVNELSNAVLQNTTADHERERQERMENGNDAPWVCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5I4</accession>
    <name>A0AA38N5I4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1110529</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5I4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="735"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3737313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="923" mass="99899" checksum="DE5179883DE60168" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1M6</accession>
    <name>A0AA38J1M6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_140956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000138">
        <property type="protein sequence ID" value="KAJ3710500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1M6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041255136" evidence="1">
        <location>
            <begin position="34"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="267" mass="28019" checksum="9C2CDE6EA10516D4" modified="2024-01-24" version="1">MGSSSTMISSSIFFRLLCCISYWILEVPTIARGAQNQAATTSAPPTPVTLYEVEPSLFSFDSANARPIDGTFELDVSIGGISSDSSGIVTTYSLGEYVSDNLVYTTTATSQGQVTTETVKTPDLVETMNWTIVESAGGAWATFSAFISSNTHELEAGEGEYQSCSFDSSGGPSASCSVVEFEPFITTVFSGSTAQETLTGLNTFTTTYGGFRTALTVLTEAAVVPSQTSSSSSSAATSASNAAGRIFLERYCGIILWLSAVLVMGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J214</accession>
    <name>A0AA38J214_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor, Myb superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1008813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000116">
        <property type="protein sequence ID" value="KAJ3711665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J214"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="122"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3711665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="19018" checksum="DDD1F483227B1446" modified="2024-01-24" version="1">MFQRERRSWTAAEDQLLRDAIAQGKASDPARTLNPSKWHAISRHIPNRNNKDCRKRWFAKLAKADVAKGNWSPEEDERLLKAIEKYGSRWTAIATVVETRNSDQCAKRWKDTLNPSIDRTGWTATEDAKLVEAVNTHGKVWSKIVKTHFPGRTGLAAKNRFEAHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2C4</accession>
    <name>A0AA38J2C4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1228294</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000105">
        <property type="protein sequence ID" value="KAJ3712764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2C4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="13"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="460"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="857"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3712764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1211" mass="133600" checksum="6A82015D1173E544" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J597</accession>
    <name>A0AA38J597_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1207120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J597"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="381" mass="43213" checksum="EFE3A05213091A8B" modified="2024-01-24" version="1" fragment="single">MSFVPRRSTGALLILPEGASSTDHKSRDEFRDYGIIWAKKWFQFANSPPYSRGTKNLYLVTGCDKTRAWGVACFLDAPVGSVIMHFVPTAGELPKYRFARRDYAEVQSGSDTFGNHSGCIFTRGFKIAIRQRPVIRTKTSIKVTNFPELNPDVNDIFQSQNNVRSFSSWGRMLGHRGGGTSSDLVDEDVSDRDSHPFRAQVYHPSDDINDWILRQFPQVDIAMTHDEDLSAVINEDETEVPTTKEFIRRLSNYLTFSEDGDICTAYFNVPRSPVKVIALQVSMESWKEGQDQHVISNLNDMSVDTRHSPYQNKAATLALNNLEIGRATLHREHVFLVFCENVCTLVHTVVKISDEISHGKLDPRLESDWETLCLILQEIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5H5</accession>
    <name>A0AA38J5H5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1042038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5H5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="233" mass="25957" checksum="F27E3AE71B400DFB" modified="2024-01-24" version="1">MGELGVYANEDMNAYTRLQSRLDPSWQRNWGTVFLEPNRASGLVDIEQQTEWSKVFRIGTQSSASYLDQISNELARLVEQTSLEDLPVANPKPSHIQHERVHTQSRNRNSSRHDSSHPGSRNPSDSPASRIPDRPPSTNSRARPGGSNTLTRNSQSDRRAPSRPLEVVHPLLLEAAHPLLLEVVFLLLLEVALLLLTPAAARAILFAAVIFNLVAATRMTALNQVDRTNTFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J647</accession>
    <name>A0AA38J647_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_595000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J647"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3724242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="462" mass="52424" checksum="D548ACFF3E5A8288" modified="2024-01-24" version="1">MSSNTVSESRVKLSFLRRAGSSIQQADRIHRTNLPALAGWIKKLTLEDRMEKNWGIERRNAERREIQAMHVAGLSDTEGSPVASLYSITSEEWDSVRKSPTLFQRLKEWIPARYLGWMTQMNEAEMQAKLPSQTAVANPAADRANSKLMDPIVEHVEDPTAVTEVDIPHQLHEMAKYHRYLPLPIFTDNNLLYVRNHLSKIKTEKIRLPNTTEKISILLLSDILDQLNIREVSVNEGLTYAKFEQAAANYYRFETERDPDGHAGNRSTWTKSHFLFWTNRSDAEDTFPFWKPLELEMRQARQDRNLQFDLNSYRLTWSRVLIAQDYSRLHPHPSSSSAPHSNSLSGSDLGKKRPAESDIPPRPFSKGGKSDSRESCCLGCGQAGHPAGDHQGKHGPLLWARWVNSSSGYVLGIPNGPETRICYQWNLRGSCKSKSCPNAHVCTFCGSSAHHAFAFQCRTRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8G8</accession>
    <name>A0AA38J8G8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1040155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8G8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="142" mass="17319" checksum="6D085FB46BDC4450" modified="2024-01-24" version="1">MTSDFERRKAQWDNKCPRAHRRWLPPVRVTRRRRAESLAHLLLEMRSMDRPKRYCAHCRRTHIEIFVFRGHWNRTWRIVIRPLLLRVAIQQSDYAHTADVSRHPDTSDNIDIQMLGIHNLGEIILKNLLDYMRRIQHYFELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9X5</accession>
    <name>A0AA38J9X5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ELMO/CED-12 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1031300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9X5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="353"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3721355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="765" mass="85979" checksum="EC150558AD0BBE74" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA82</accession>
    <name>A0AA38JA82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_889151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000095">
        <property type="protein sequence ID" value="KAJ3713969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA82"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="503"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3713969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="724" mass="83149" checksum="9C1FFE68F2BAEBCE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAG9</accession>
    <name>A0AA38JAG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1092831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAG9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3722712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33122" checksum="E68BAE439FF784C5" modified="2024-01-24" version="1">MSTQVDLNEQSATNLFDLRGVVAVVTGGGSGIGLMISSTLVANGATVYIIGPKQADLDRIRGIYNDASTKLKSGCGGKMYGLEGDISSKTEAKRLAEEVAKVQPYVTVLFNNAGIQAGQFTPPSQASAAAYVSAFFDKIEPQDFNNVLNTNAVGAYWMTFAFLPLLEKWKNSEEQVTKKFVPQVIMTSSMNGWTKDSATSGLSYPYMFSKSAIGHATSSLAHELLPLGIRVNGIAPGLFPTEMSLPGYSNEAGVTVAPPDKTWGFEIPTVKTGGTKRDVGALALCLITNWFINGETVLIDGGTLLKHPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAX4</accession>
    <name>A0AA38JAX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1003412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAX4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18258" checksum="613927895FD1AE43" modified="2024-01-24" version="1">MRSSFVSPSVLLDEVNGEAIPTRRERSGTIGTLSSAFSSSTTDSTNSTTNSSPERQSLAKKKRRSLGLTLGTVSIGNISGIRSPTIGTARGKKRKLVISGIEINDTRAYQAVKNWCESFGELKKFERRDNGNLVVDWRSKSVNDMVCRVQANVFIKGAGSVALSWIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB51</accession>
    <name>A0AA38JB51_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1006664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB51"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3716709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="108" mass="11826" checksum="73CBE944F5256D43" modified="2024-01-24" version="1" fragment="single">EFANRHPTITFAHAIPGAVRTNLFASAETSALTKKAMGLSMTLLGFLLTSPEDCGEYMLNGIVNVANAPGAWRINSHGEDLGKKRYYGSEEERKKLWQHTVEATSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBK1</accession>
    <name>A0AA38JBK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_998176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBK1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="405" mass="44505" checksum="362D6AD44C07EB37" modified="2024-01-24" version="1">MNTSNVVDLQTDTSAENTGNNSARKIPRVRVDVDTIPDMMAARLATSLLGHVLFLKNQIPFPIVQLSRLPGGKACTSNPRTEKLKRDLIDSFDTLSSHLDTTFTALSTAFARCSQTAQSISGAENSERKFGNPAYMAILVGPSIGTAKSKIIFAVDSLETKIWGLRDDLPPKVDVQEEESSESSPEDGEGLEEAHADSDSDDENSHSGPEDSDSESETDSCSTSSHTDSPIPPPRSQHTDPSTSSPSASYLQDHAREQQKIRVADQLLSRTLAIADAEGRGMACELAPTQTHILLRAPRRFAHPAWVPRLNFTNSLEHTLTDFLEETRLSIDVTTEEKTKNKRTQRQTVEGVWVAGRTVFSDTLSTQSSPASNFDKQETVNQIQDEADEMIWWSWDGKIVGFSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBK2</accession>
    <name>A0AA38JBK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-chitosanase</fullName>
            <ecNumber evidence="10">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1159553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBK2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF6">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041485225" description="Endo-chitosanase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3718093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="290" mass="30677" checksum="55BBD71231B50E8F" modified="2024-01-24" version="1">MPASTFATRCLFLLAVMSMVVAAPIPIRLRNTHSIIIRNDPDSGSDSDSSSGSDWDSDSGSSSDTDNTSVDSDSSTGNSTSTNNVVFATDLSIDVATILQSVKSATFNPVPGANYGTGHDDNKAQIYKLDVDGSVGGSVYAVEADMDVDCDGTDYQCEGNDDGQSETSYGALSAERVPFYVLPQSFVDQQNIRGNSLGAIICNNKMFYAIMGDTNGDSPEVIGEASWLLARTCFPDDDLNGAKGHDQSDVMYIVFGSLVPGGISEDSPTIDIDSLKELGDKTMKAFKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBL3</accession>
    <name>A0AA38JBL3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1005892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBL3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="228" mass="25423" checksum="0BF6462FDC902B55" modified="2024-01-24" version="1" fragment="single">MTKWVAVDVVFPENCKTLFIEKLLTSNRNEEDIYGAPDTIIQLSTSPQIPVANFSEQAITISKGQLLGNGHNAERWLDQTGRIPKEDQRRFESQAQVLKAIAEMNEKEEKHSALIKSQTDLNKKSRSDQEIPGEEYGEPPVEGGPKTAEVVEDLVSSKRLLEEVDICKELSADQVDALQQILIRNEEAFGLDGRLGNYPEEVEIPMLPNAKPIALPPIPLSPVNREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC14</accession>
    <name>A0AA38JC14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromatin remodelling complex Rsc7/Swp82 subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1005424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC14"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="534" mass="58278" checksum="7D8B63C69F065022" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC27</accession>
    <name>A0AA38JC27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1002062</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC27"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="598"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3726532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="805" mass="89367" checksum="4E009A9A211D54B6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC53</accession>
    <name>A0AA38JC53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_183842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC53"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="287"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="818" mass="89193" checksum="64354E23E17F5932" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC81</accession>
    <name>A0AA38JC81_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Barwin-like endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1096044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC81"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041211832" evidence="2">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3720194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="143" mass="14707" checksum="AC8B439CD5AD4AF8" modified="2024-01-24" version="1">MFSPIMKLALALALISGLALVAIPSNASPINSTLLARANTGDGTFYAPGLGACGVTNSATDLIAAMAHATFDSYPGATGNPNTNPICNKKVTANYQGKSVTVTITDRCAGCAGEFDLDFSPAAFDKLADESVGRIHGMTWDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC92</accession>
    <name>A0AA38JC92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1001598</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC92"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3727310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="391" mass="43547" checksum="A2E1D9F25D8103E3" modified="2024-01-24" version="1">MPFLNRTQRLLASSRPSFHPVSLPLPFRRLFSVSHLQHNQPRSNANAPRVIFSGIQPTGIPHLGNYLGALSNWVQLQNTAGPSDELLFSIVGWHALTLPQHPQQLSEARMDMLAVLLAIGIDPRRSIIFHQDDNPDHTELAWIFNCITPMGKLRRMTTWKSRLAASKNQGDDVDVDEAGLNVGLFAYPVLQAADILAYKATHVPVGDDQTQHLELCRVIADQFNRNFKAEQSLFPLPTQLNTPSKRILSLRDPTSKMSKSSPDSSSRILLTDSPSQISQKIRSAVTDSIPGINYDPVNRPGTANLLTILAACNNNEDVGETARRYGGKNHGALKKDLTEAVEEMLKGPRAEYEKLRMERAYLAQLAREGAEKARLKSEVTMREVRKRVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCI1</accession>
    <name>A0AA38JCI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1158543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCI1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043708">
        <property type="entry name" value="DUF5648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18885">
        <property type="entry name" value="DUF5648"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041439206" description="DUF5648 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5648" evidence="2">
        <location>
            <begin position="35"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5648" evidence="2">
        <location>
            <begin position="232"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="445" mass="48003" checksum="992E2BD7CDFB8C6B" modified="2024-01-24" version="1">MTVLSCPLSSLLLTVALVLADPTSSCADTSSLITLFRAYSGNASDHFYTTNVSELDNDALLGGTYTFEGEATFLWSTSQPSTIPLFRLYNQDFVDHFYTISSDEVLEMIDQGWAYDNTPNHTAGYVYPYSICGAAPIYRLFNPKSVDHFYTMNIAESQDAMKDGYQDQGIAGFAMLPSVDGSAVNDSAGPFFLPSTMTALPESQETATSSSSCADNANVVPLLRAHARTGTGQDHFYTTNSSEMNAALLNTYSFEGDAAFVWSTQEASTVPLYRLFNQIVNDHFYTIDANESNVVLSLGYAFDTDNHIAGYLYPYSICGASPIYRLYNPSTTDHFYTMSQTESASASGYVVEGIAGFALLPSVDGQPQMSASPLLLPVSLKPSASTLGYGFPTTIALGPTSSIVSNAGIGSPTSSPNSEEVSQSTMARRAFIISMLWSVATWIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD06</accession>
    <name>A0AA38JD06_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1040988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="232" mass="26306" checksum="B23B367BDE3306C8" modified="2024-01-24" version="1">MSFMVRLCCPSLQVLAEGVVGEFFGHSGFVPVVELYCCSCPFELEYSLPATSYLVQIHPLAKIHTFRALSKRGFIHTGLSNSPNQLPDMIMSFDIIGTCNEIQASSLPGFGWYRFGSDPAGWHIAYVGHRDDFNPALLSSRWAYTYFKFTKRTANVNKLIFVAAELSRVNHNGEFQISESDLEPGIQNPLVRFGNLNRHECTQFIFISLVVIIYHLIVQRISSQFYIMSFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDD5</accession>
    <name>A0AA38JDD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000100">
        <property type="protein sequence ID" value="KAJ3713249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="460" mass="51084" checksum="61DAD343FC635946" modified="2024-01-24" version="1">MGNGRSRYNRGLTQKKDIQANSFREKTPVYDSEDDEELDIDQLLSSSPVQLKKRRALSKPAVNPSARKKSAKIVLMIPRHDKTNERKTYNDRDVDYDTVMEDIYEAIGCKEAKAKPAIGYKIEGAPAKTGAISLMSSEDWEGLCDDVLEKQEAKSKVFKINIIVAAEYLDALNQWKGKKDGKGKERSDRKSSKKKKNAVKSFKFDSDSDSEDDSNDGMGKSTMDKETRFIGELTSTYGNCALCKPKICKIGQGIHVSLTFNMRAAWAAALAREEAGVTLSTPPKTEQFRQFHHSIELPTLVSNLSDPTTPSFGSNMSVMKEFVAPIIGAFAAVNQLSNPRQNNPETPTPHARPVQSPQCVGIPSSDGFDEQDINPYPTIVDFFTSLDVVEPQRNLSRYVATLTGLDFYNIDNIAGLTVRVLQDDVGMSLGNATHVLNMVKKKIHVVNKGRKEFRNTIGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDH3</accession>
    <name>A0AA38JDH3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1042196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDH3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="112"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3722179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="596" mass="65830" checksum="B95423E746CF4F0B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDI6</accession>
    <name>A0AA38JDI6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 69 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1059982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDI6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF2">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041454573" evidence="2">
        <location>
            <begin position="26"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="604" mass="68276" checksum="D926D447EEB87CF1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDT0</accession>
    <name>A0AA38JDT0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1107817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000120">
        <property type="protein sequence ID" value="KAJ3711430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDT0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041454399" evidence="3">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3711430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="314" mass="34536" checksum="A4AF2DBF1651307F" modified="2024-01-24" version="1">MLVVALLLCLFATLDVAFGLHHNLDAFSYYHGPGGATEELNDISYWVNVMKTADYVAQTFIGDGMLVYRCYIVYEKNWKIIIPSILFWLGGSVCGAILTYTFATLRSPALIDTSKAVPYVDTMIALSLTMNTLTTALIVGKIWSVDRQNATLMSNTTMNATHTSKLHRVMRIIIESAALYTISTLIFVITYVAGSNAIYVTCDNQKLHLQVVQIIGISFNLIIIRVDAGKSYNGRKAESISSLLFQHQPRSREQSSPLSLPSTTTDSALNSNLDSEFTGRKGITLDVDVVHKYDDLEQGTNATGESALKPLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDV3</accession>
    <name>A0AA38JDV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_659425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="75"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3722808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="324" mass="35354" checksum="B51B7F27D7DB87C1" modified="2024-01-24" version="1">MLPPRAYIFIGLNVTRALSVIAMLLVFSSSIEVMVTNIKAVNYYEAHKGDNNATMSAMNMDYIAGSTVPNQPAGIFWAIVSSLLIIFQTVILILSECSWPISFFDHFFPVLGSGFGTGALGIFQCLIGAQILSHHVDEFALVSAFFLFSLGCLNMLIGLIFRESAKSKRSITSWRSESKAVLPTIDDPRPVFVNVSPNYTGNSEKPQLISEFGSFRSADKSGYGFGRQGEKAAGLRGFILQRPEESLPRYVSPTPPASPPTRTVALGRNNSTTSSFGSPEPVRGSVQSASHYDDDERSTVAEEEDEEAIRHHSPPVFKSSRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE55</accession>
    <name>A0AA38JE55_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA splicing factor PRP21 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1133711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE55"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="139"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="676"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3723476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="761" mass="84455" checksum="5FE10400082ABB59" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEG0</accession>
    <name>A0AA38JEG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1153423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEG0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="576" mass="65455" checksum="C42FE904359740A0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFE4</accession>
    <name>A0AA38JFE4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_194894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFE4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041398992" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3733794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="146" mass="14979" checksum="A91358BE9373FA22" modified="2024-01-24" version="1">MFARFSLFAIVTALGAIGFSWAQTDPACSSSNGNIVIKVPTTSTSFPTGVTCQEIATAFKISLLELESANAGVDCQNLAAGSVLCVPGTTCSQYKVQAGDTCALIVTKNGIRSLAALQLSNPQIDDSCNNLTVGENVCVPKPASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFQ7</accession>
    <name>A0AA38JFQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1084315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="964"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1621" mass="173946" checksum="58E761B1579FFDE5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGS0</accession>
    <name>A0AA38JGS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_989471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGS0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="41"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="468" mass="53381" checksum="98A883CFC78FE067" modified="2024-01-24" version="1">MAAVKTLHFDSNPPPFGHEMRKCFSFDPEYINMNHGSYGSLPSPVAEAIKPYYAMAEANPDLFHRFTSVDLIRNVRERMAKFIGAAHTDEVVFVPNASHGLNAILRDFIWEEDDIICSCNTTYKSISKTAQYISDIPPHPENSQFTILFPTTNNEIIENWRTYLQSLNEARARSARRLGRRPKIVAVIDSIISVPGALLPWKEMVKICKEEDVWSVVDAAHSIGQELDLNLAEADPDFWVTNCHKWLYAKRSCALLYVPKRNQHIVKASFPTSHAYISPKKRTGPNFVEQYEWNGTLDFVPYISASCALDFRAWLGGEHVINAYCHRIAIEGGKRLAQILGTEIIDQGNDFQFTLNMVNVAVPFPATMSSDFEIDMAFRRKLLIKKKIYPAFFYHNGKWWTRCSAQVWSQVEDFEVLGEVILEACKEIIDEFGDGSERTMTDVEDNMEKLAVREPNVQSNQEVVCIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHE5</accession>
    <name>A0AA38JHE5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1156352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHE5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="31"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3730012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="291" mass="33366" checksum="42A8EF947D1924E8" modified="2024-01-24" version="1">MPIPGLDNHVYPIGNESKGQALYFEYGQWRTQTIRAELHELQHANMGRKSAFSSIVSVLTLDFLRYAEVDRRSLDPPPVVALRLYQLVQTGPYNFQEIEIINYEDIEITGLLCTAELIPVNEKRSEHHYDLHTDGSYEYNSDHHMSTNSDYLPSLAQHDPVPESEVARLTTKVLIGSKVVQPHIINHNGRQKMLFVFSDLAVRNLGVFRLRYKFFDLFSAAPGRHTKIQAECIGGNFRIFSTKHFPGLQVSTDLTKILSAHGISLNIRNSERRSKKRKNGRGRHQIDEERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHE7</accession>
    <name>A0AA38JHE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1159894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHE7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="166"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3717232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="609" mass="63936" checksum="ABE35D29FD4F162B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHR2</accession>
    <name>A0AA38JHR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1057305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHR2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="74"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="492" mass="53844" checksum="6D0D8AF69A70E723" modified="2024-01-24" version="1">MFTPTITVYYGSLINPTTLTSYETITGCLIAVNAHGNIDWIIHDVKDSSIQETLLQKGLFDADVTIVPLQEGQFIMPGFVDTHTHAPQVPNTGTGYQSELLDWLENFTFPMEANFQDVDFAKQVYPSIIKKFIASGTTTCCYYGTLHLESNKVLADIVHSLGQRALIGKCNMDRNCPSYYIEPSSSRSISDTQAFISYVRSLAPGPSDNPGNPLIYPVVTPRFAISCTNELLSSLKTLVHLDTRLHIQTHISENLKEVEYTKELYPDCEHYAGVYDSYGLLRNNTILAHAIWLQEKEIDLVKEREVGISHCPTSNFNLRSGIAPIGKYLDRGVKIGLGTDVSGGFSASMLVAMRNASIASTVVALQNNPTNAPIKEGKFTNRQLPLATLLYLATKGGAEVCVLDQQIGSLEPGKSFDALIVDVSNISSTSKWPGDSDVDPALRKISTTTSSVRSSSRAILEGLLEKFVFCGDDRNVFAVFVQGKLIGGTSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI67</accession>
    <name>A0AA38JI67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1000205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI67"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041401323" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3730870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="144" mass="15502" checksum="DD080627454B70FA" modified="2024-01-24" version="1">MQIVKWALFLFAATVTTYAQDSVSEPPAELVIETIYLPEACTSKAGSGDSIKVHYTGTLHATGDKFDSSHDRGSPLPLKLGVGQVIKGWDEGLQGMCVGEKRKLIIPSHKAYGSRGFGNIIPANSALVFETELVELNGKSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ24</accession>
    <name>A0AA38JJ24_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1148802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ24"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37229" checksum="F197B8778091A87A" modified="2024-01-24" version="1">MTNAKWVDQDKAALVDFVYSRKAELGDGGNLVKQLANGAAAHFVQIGPPKQGGPKTANACQTQWKSLKKIYEAIRDVKDHCYVGASGWPWNDDNGFQVKPENADAWRAFSKAHPVFSPFANRGWPLYEKMSEMCPKIPKGRHVFSAGSSQADLQLSQSGNIFQSILSESQNDEDGLSLGQDEWPESPRHREASPLEEETEAASQSLSQSVSQADKEMIQPTPVKPASAKKRAAEGDDTPATKKARVTGPDALYAISQSTLAVSSALRDMLGSHVVPSPERRKQASLLLKDDHSLTQTDKVSLHLLFSKNTAAADSYRNAEDWIRDDVAQRLLQLDDPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ28</accession>
    <name>A0AA38JJ28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1053266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ28"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="86" mass="9715" checksum="F131DFC37FAC8AB6" modified="2024-01-24" version="1">MAYLLTVTSQCSFLPLVWRIAQGFKIPSLSATKYDHEIEFNHTTHCASFPIRKQFVQLSAFPPLCVLCSKYGRVAWIEHGVTPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ65</accession>
    <name>A0AA38JJ65_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1086128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ65"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="226" mass="24171" checksum="D1772456903CA0FB" modified="2024-01-24" version="1">MPSFAELKQKAVKAKDATVSSVQNTKDRHTSVPLKKTNWNPYDGNGPPPPPAPRTNSWTKPPKPEPPKLPPPIRRDTSISSNSSGFSRSPQPPSISPSPSPSPSPALPSRAPPVINRATRPPGSAGFTAATANSPIPSLRSIVPTSTPSASSKSLPSRAPSLPPRTPSLPSRTPSSTSYQKTPLEPELDSRIDWANLSAEDKHVFFSWLDEFFERSYGIVSTGSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJX0</accession>
    <name>A0AA38JJX0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJX0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="91" mass="10405" checksum="D97157B377EE4D29" modified="2024-01-24" version="1">MSLKPSTKLSQNRRMHPYAHALRRQREHLNEVALANTLPPPRNFDAAPDRNVAEKIHRALNLVIFVLSIACLMLRLFNIILIKEIIATLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK59</accession>
    <name>A0AA38JK59_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1037863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK59"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37336" checksum="CBE76AAF93C5BCF6" modified="2024-01-24" version="1">MNWRSIFLQKHREDRLPETTAALAQPNSSLNDFQYDMVDCDQASSRAELSSTGLKATRIKRQSESHSMTCLVRILPADILAEIFSMICLGDYSLKINRPGPLSKESFLSSPTLVLTQICSYWRSLIFSLPLLWSSLSIESRHLYGRPALASLVVAYISRSGSVPLTFQLKSDDDAPEVELQVFDALLEHASRWQKATLLVSSPWLLRAKTKLDSRLVPGSICFPKLEHLVLDVQRDSRFDKDVMYLPSQIIQSSPRLNTFHGLGYDFLLRGRGFGNSYGRSLSRLLRCFPILEVFSIGGFELAENASTHVGLEEELPLYTSRGPGNLSDFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKZ6</accession>
    <name>A0AA38JKZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_171896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKZ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041419720" evidence="2">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="297" mass="33329" checksum="BB435FA1F1EA29D2" modified="2024-01-24" version="1">MVYSRSVLKAVIAVGAASSVLSVPLPPTGTSDSSAVTATFSVPSASGTAAPTSEGTSGAPPVPLGVPAPGVPVTGANGAKTLSAREFNIIVEDEEEPHSHHRHHEHSVEKHIHHHHHHHHHHGEEEFEVEVKEHRGHRHHHHHHHPHGEEEIEIELKEGHRHHHHHPHGEEEIEIELTEGGRHRHHHHPHGEEEIEIELGEGRRHRHGEDEVKIEIEEVPHRHHHGVSIFAFPAIPTFSLIINAWFLQHHMHHKHEPEVVEVVAVPMHIPGPGEHREHKVCPFSIPVFTSLTYEVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMG8</accession>
    <name>A0AA38JMG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_994697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1493"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1573"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1503"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1580"/>
            <end position="1598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3733738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1598" mass="178350" checksum="6A8C0BEED53226BA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMI0</accession>
    <name>A0AA38JMI0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_557701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMI0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3726476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="415" mass="48380" checksum="212F3740D3525959" modified="2024-01-24" version="1">MALYSPLSSAPAARWKQFLLTKKSLIASIIVIFSFLGLLELLLERGISSRILSSFSLTPNSSPSNQSPLSCSNLFEPSSFQHSTPRPTYSRKANATFLTLARNSDLAGVIHSMKQVEGRFNRDRHYPWVFLNDEPFTEEFIRCTSAVTSAKTHYGQIPRDQWVQPDFIDEERATKARKSLSKMRGVFYADSVSYRNMCRFYSGFFYRQPLLQDFKYYWRVEPDINYRCEIEYDPFLYMEDNNKAYGFTISVPEQKETTPTLWDTSMEFFNRNPQYLHPNNAMRFASKDEGKTWTRCTYWTNFEIGDLDFFRGSEGYNKYFEHLETAGGFYYERWGDAPMHGIAISLLLDRERIHHFDDIAYEHTGWEQCPDPSTPAYERGRCSCDYGNSMAVKWKRYSCQADFDAALAVPRINTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNG7</accession>
    <name>A0AA38JNG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNL zinc finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_474216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNG7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3729970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="196" mass="21267" checksum="DB8EC8DEDE53FD96" modified="2024-01-24" version="1">MLPSRLYRNVHVGIPPPLRSLLHPNPALPPSVRLQLRLRLGVFSNTAANTLKAYSTTSPPSGSNDLSTSATARNPETIHGSSPSSSSSSSSQTVTSQALPEKMERQMSITFTCTVTDCGTRSTHAFAKRSYERGIVLIECPGCHNRHLISDHLGWFKESTEGGKLNTVEDILRARGENVRRGHVDGSGGVVEYMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNK9</accession>
    <name>A0AA38JNK9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_465698</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNK9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="191"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3730090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="265" mass="29771" checksum="8F4A4271DCD701B5" modified="2024-01-24" version="1">MAEMSAPPAPDAMAISMVPPAVDAIQAAPAPPAEPEHISETLYIQNLNEKIKIDVIKASLRGLFKTYGEVLDVVAHSNLRMRGQAFVSFADAEIAKKAMKEVKGFPLYSKPMQISFARTRSDAVVKKMDNEHFDEHKAQRAEHKRKTRYTNPLKQKFKAKRLASEMDGATSAPAPKRPNVQMPDEYLPPNKILFLQNLPESVTKEQLLGLFNQYPNLHEVRLIPTKKDIAFVEYTDEASSTVAKDALHNYKLDGENKIKITFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNR7</accession>
    <name>A0AA38JNR7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1081012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNR7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="68"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3731003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="456" mass="49672" checksum="AA38E2B6C0E20D08" modified="2024-01-24" version="1">MEAMELHVINSTKATNTSTQTLSHLNRVIDTEIDTPKDIPITENAQQGGDKREEERERAQYRSREYIQLAALYWCMFLAGWNDGSTGPLLPKIQEVYNVGYIIVSLIFVFACVGFISGACLNVPLSEKLGFGKTIVLGSFLQQTAYALQAPQLPFPVFVMTYTINGIGLALQDAQSNGFVASLKDHAETKMGLLHASYGAGALCAPLVATQFSQMKHWSFYYLVSLSVATINTIVQIAVFRFKTQDDCLAQIGQEPGEKGTSEHSHFRQIMSLKTVHLLAVFILVYVGVEVTVGGWIVTFIQTVRGGGSRSGYISAGFFGGLMIGRIALLWVNQKIGERRVLYIYSALAIGLEVVIWLVPSLIGDGVAIAIVGMLLGPMYPITMNHTGRVLPRWLLTGSIGWIAGFGQAGSAVFPFMTGALASKFGIKSLQPLLVSMMVSMTILWALVPGSPRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP48</accession>
    <name>A0AA38JP48_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_433493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP48"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="327" mass="36000" checksum="6288C6EE5D4C0417" modified="2024-01-24" version="1">MPPDVYHNAQYCRFYDAGYCRNGNSCRFKHDPQHFLLVAVDPNGIHTPPAVTMHEASYMSTPYIFPYIPPSAMSSPICYQVPFGLYDSYPQYSPPLPPPSQYHPADWYPQNLPPNYVSRSSSMDSSSITSSLVTVSESSQCITEGNVPEPVAEGANHPEYVTSPDHCSNSALFRGSSGIAKAKPQEIQATTKIDTNKPKSNSSQPRVHSKPYNERKPSKTVRCKFHKPPKKLCPKGDNCTFIHSDPSLLTNAKGVSWEVESSGSQKNNSVSPKKDTDSKLPSPGHTLPAKPLTYFEAERQKGFFAVTWRVISGGVQMGVNQPDSGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPH5</accession>
    <name>A0AA38JPH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_420600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="110" mass="12191" checksum="6B9CA114BC8C0818" modified="2024-01-24" version="1">MARYSPRIACFIGLQTGRIVLDYVMRSRPKSERPTFSPGLQPYKLVHSKPRNGSAEAGSETVFYSIPSTSGKTQGYQIPDKVKLFTQLGVDLKMLKDGNLVTANLVEIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQA6</accession>
    <name>A0AA38JQA6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DFJ43DRAFT_184145</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ET3784</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 22" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="36"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="463"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="692"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="885"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3734095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1358" mass="147531" checksum="6774470AD5E62A34" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQG1</accession>
    <name>A0AA38JQG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1155521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQG1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="430" mass="47358" checksum="E3095C4A35D8EBA0" modified="2024-01-24" version="1">MEGASDIADGDSGISPDEISAITDVPIFLGYIFCYFLSGILVVQVFMYYLSFRRIDSRYLKLTVLAVFFVESLSTVFATMIVVMALIKDGYLSYSIVLWGFKAVALLSGLVCSMVHVFYCWRIHILGGRWIIIIAIMILSVTQCVMVSLSGFGAFEDGDVLGAGTQTIKEPWTLLFNVSWLAGAAICDIIIAITIIHLVRLTLNTKETDALTRSTATWYNNEALHNESFEHASGKETPPNAYGTDPKGQEAYKHRYSIQADKRYSTPTSALSNQQSTTYCFHLEVPTRRNSILDLRGIHSHDHIEDDSYILQKFKPMPSIATPSEGLYLRLGKGVDGQTLAKSKSSLSLSSTYIVQASAIHEQPADTLNFNPVLDSPNPGSKLEAVDSRENLESRVLTIGSDTVPAPSYGPFPLKMEPLRTLEASLQPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRD8</accession>
    <name>A0AA38JRD8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1149965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRD8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="158" mass="18082" checksum="EA4B756CF14DFF65" modified="2024-01-24" version="1">MGPAIVRFNSFWALFQDFSSSLRFMINDLKRQLLDFSSSGRLERMIVRLEESLVNFQIVLPCALATCTLLENAFQDIYTLLSRVSLQTTVHVIKRIACGGANSLEDQEPYSLLLASLSVQTFKITEISKTLQRQSLKRFLDIVRRDRNVIFSSRTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRW5</accession>
    <name>A0AA38JRW5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1064878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="700"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="742" mass="80706" checksum="151187E7CFED0485" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU03</accession>
    <name>A0AA38JU03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_987768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU03"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041328575" evidence="8">
        <location>
            <begin position="32"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="497" mass="53670" checksum="1798CBAC2D2926E8" modified="2024-01-24" version="1">MFSNNSSSQTPLPKLQLAIVFLIQLTEPIAATVIYPFINQFVNDTGITGGNEKKTGYYAGIIESAFFLAECFTVMLWGMASDRFGRRPILLLGPLGLCLATLCFGLSTQYRDLMIFRSIQGAFNGNIGVSKTILAELSDSTNIAQIFSLAPMIWCIGVIMGPSIGGVLANPEQQFPSTLGKIALLREHPFFLPCAVVAFLALSFFFVALIGLKESRKRSLRRTSTRILKAPTRRRPSTSTLCSIVSTTSTLDADLESDQETVLASDSEDEEDSKTDIEPPATLKSILIPDVLLPIANYSLIALLDSSYTVLIPLTYTTSVPAGGLGLTPFHVGLILSVWGAANIPFPIFCIPRLIKRFGARTVNFVGVCSFLVGFGSLSGLSMLAGAIGYANWLVWALIPLQFLLSNTVGSMAYATAQIFVVNGAPSKSALGTTNGLCQASKTMARTFGPVLATSLFSLSKEHDLFGGYLVYVVFMLITFVCMRTTMSLPREMKNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUU6</accession>
    <name>A0AA38JUU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane bound O-acyl transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_995542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUU6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="6">
        <location>
            <begin position="231"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="393" mass="45141" checksum="53028A19F5379B39" modified="2024-01-24" version="1">MPNSTTAVPAPVVPFRSSFSVVPYLILPDLLLAIVLAFGLNFRFRLLFYALFSYVCISGLLLTTGDRMQDYSIGSTLGGQFFTATHLLLFSEPLVQYRHREDKNEPQKRSFWRRALWTWCIVHSPRGIGWNYQVLSVPPRPPPCSKWAFIRSRILQAVKFYILMDIAQSYIRLNTLFTNPPPNATITSQGWLLQMFSGAAWMTTPYAGMSMQYCLFAAASVGCGFSNPEDWPDTYGTWKHAYTVRNFWGKFWHQMIRRYVTSIGKFVCRKLGFQPGTLYSSYTQLYVAFFISAVLHCFGDVMVGWEYLGASFPFFVSQAFGITFEDIAIHLFKRTGLRNRSRVNKAIGYVWVAFWMSFSLPWYIDWAVNAGLGRSEVLPFSPVRYVLRALSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JV20</accession>
    <name>A0AA38JV20_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">DFJ43DRAFT_1038338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JV20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3733433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="300" mass="33813" checksum="5298A96B32F4FB0A" modified="2024-01-24" version="1">MFPTRLLRSSTVNANEIAHFSRLSAEWWNERGEFSFLHKMNPVRMQFIREKLLETAYDEQPEEAVDAKKVGILEGLDVLDVGCGGGLLSESLARIGARTTGIDASESNISIAQHHASLDPRLASNLTYKHAPAESLLTQSKRYDVVCSMEVLEHVDNPSMFLKTCAELLKPSGHLFLSTISRTPLSYFLTIFMAEKVLREVADGTHTYSKYIKPSELLEFFQLYRSSLPYSVNGDSVQTQSRPWITRLYSGEPTRKEAEVRGMIYNPLSASWVIAPRGAWGAAECNYLFWIRKPALNDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JW46</accession>
    <name>A0AA38JW46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1050232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JW46"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="148" mass="15383" checksum="1BCC5CF83EC17B9D" modified="2024-01-24" version="1">MKLSRSVLALFALVGSSVAQGASFAYPQDGDTLVAGSNISIKIDRPTPSGPVVEAAIGLGMSTCSSDSCPSPETSFGYLFYSGAFNPQRPAEVSPGQDFNAFQNFTVIVPSINGNAILGFLHSSFGEGAGAYYPYFESVNITVNIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1S1</accession>
    <name>A0AA38K1S1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF-4F 25 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1049548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1S1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="295" mass="32584" checksum="076A93BF3CE682C2" modified="2024-01-24" version="1">MESTLTGSALAASRAALSAAMAENNVLTSDDVGSIEPGEIQEINMEAQAEGIRTVFSDPTSFNVKHPLYSPWTLWFDSPMTKHRNLPQTPISAVPQTPLPQTPGVAAAQGWMEDIKRVISFDSVEEFWGLYNNIVPPSSLPSKANYYLFKEGIIPAWEDEANKYGGKWSIQLPKDKNKPNVDKMWLYTMLAAIGETFDPSLAASDPSGSPPNSLITGVIVSTRQQFYRISIWTRLAPGQDDDGLRERIEGVGRHFKVKVLGYTENQRLAGPLATDVEFVTHKDSEKKGKTKKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K230</accession>
    <name>A0AA38K230_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_258729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K230"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041389352" evidence="2">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="220" mass="24163" checksum="BD75E0337C50990A" modified="2024-01-24" version="1">MLNSALKFCLVLIAGVLVLTTALPLVPVNVNDMDLVASKRRALSPRSSQSNVQHAKVTFIPAKDGTSAHLPQNPQKVKNAQKVKNAIHTFLKIALPGLDTTGTISSIRVQNEDWEGEINPSETAIKSDKTQKGKGRPGPTQERYHYEQGFWLTLPVIGQDHQEKEYEASISWESHNRTVSGNIRDAEDHRKVFAEVEGGILSGPQHLLTSLKKDKSASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRG8</accession>
    <name>A0AA38MRG8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Winged helix-turn helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_980572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRG8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3719075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16655" checksum="A5B4955BC48BF118" modified="2024-01-24" version="1" fragment="single">KNTAEIAVDLDMPLRVVQRILHLWKEIGEVSRRRKGRGRAQILNCSQCQMLVALLEHSPDILLDELQSELSTQYGIDVSLATMTRTLTRLGYSRKKVRLNVTAAECLQHKVTTFIMQIKDEPFECLVCADEAAVNIHTTYRENGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRR3</accession>
    <name>A0AA38MRR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_493113</name>
        <name evidence="2" type="ORF">DFJ43DRAFT_718122</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRR3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="305" mass="33839" checksum="EC339D41B5D23C46" modified="2024-01-24" version="1">MRKLESKQKHYDLESVFKSETRRKVLNSYVRLKVNNHKGALRRLVLASLKNSTRKDLAQTALKIQQSLGISFTNNDNSRFMARVALLRQYTQDNVIGKDEGDDQKKQDSFFVGFDTWLGAKVAVWGNNFDSEDWRNYLTQTLAAENNANNTTIATPPDVQDLPTSQLPSDRVGLVSGPDRPIAPLPTRRIPSSLQHSIPVPTQSRFPDPAPCYPPSSPRLASSSGHRRSVSASIEGTGGLAPFRFDSSPIMQSHHLRSNSSTPHHNNGNSRFPSTNLLGMQVPPSSSPASNFESTGRTSAFRPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS17</accession>
    <name>A0AA38MS17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_657663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS17"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001467-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3722782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="159" mass="17432" checksum="94963E889C2A7D64" modified="2024-01-24" version="1">MAESVVLETSLGDIQLELYWTHAPKTCKNFAELSRRGYYNGVIFHRIISDFMIQGGDPTGTGRGGTSIYGQKFEDEIHPELRFTGAGILAMANSGPNTNGSQFFLTLGPTPYLDGKHTIFGRVSSGMRVVQRLGAVAVDAQDRPKEDVKIHKSRTVQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSC8</accession>
    <name>A0AA38MSC8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_575362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSC8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22796" checksum="67F31018ACDA4C17" modified="2024-01-24" version="1">MSGEEPEVIDLTGPDENDSEQDDQEDSSDQDEEEDSGQSSDHSDDSVEVQINSDTRSKLYLSLAALPETQVRSILNQLIEQVPAVEYALTRELVTLKRKLDHHDYERHLERCKNCYEEFDTQLKKRNNECSFHPGSLEPDYASFPDWDEDVHGPIDNEETRRHYPENFIWSCCQADGNSEGCVHGVHQSANAQKKARVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSI6</accession>
    <name>A0AA38MSI6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_965813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSI6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3727275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21272" checksum="CC24407D0767CCC2" modified="2024-01-24" version="1" fragment="single">SGRKVVLVDTPGFDDSRDGRTDTEILRKISEFMISEYDQHRKLNGSIFFHRMSDPRFGGQSRRSLSELCGAATFKNIVVLTTFWDRVNEQEGLAREEELKSNSNFFKDLVDGGARFIRHDRENNGARQVLDHIFTLVPTTVQIQKEIREEGKSQEEIAAGSAQREEINRMVAKHKKEMDDLNIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU00</accession>
    <name>A0AA38MU00_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_309075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU00"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="192" mass="21703" checksum="0B7E1A59F5592CC8" modified="2024-01-24" version="1">MFTINHLFSRAVSNSNVSSNLTSIISFLATIFGVLYFSTLLWVINLSRMQPRAFKRESSRHLQRYAPFVYIFIVINSLAEAACAFWLLVHYIHQQSFPSSSSRTALQLVIFCSCWTMFTAGVFTILFIHPTWSTHPLASVGTQVIWVILTLCVWVAGTTVLVCKLPSQFLDQDCISLAYCGQMRALFGLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU04</accession>
    <name>A0AA38MU04_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1073956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU04"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041210548" evidence="1">
        <location>
            <begin position="25"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="230" mass="25423" checksum="ADE474A981726463" modified="2024-01-24" version="1" fragment="single">MYLRANTFFPTLFVSLLFIASTFAIPISPDSNSSPTLVDRDVVPLHARVNAPSASPPPYGSTAIATKPLEANVLFLGEQLPEEDFTALRSAIETMLKPVVWLFKSEIQASIPRDLSKYLSEINDIPVTTIDYGLRSRITAWTSDTEYEFDFTIASNVKQNLFSINGHPFHGTIARASLSNGGKLTGRIWALNQQTMKKDEIVSFTDGKAKPRSRLSHALTRYGLRRGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU14</accession>
    <name>A0AA38MU14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1008090</name>
        <name evidence="1" type="ORF">DFJ43DRAFT_1008755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000115">
        <property type="protein sequence ID" value="KAJ3711850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU14"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="162" mass="18940" checksum="D1ACE33644493A32" modified="2024-01-24" version="1" fragment="single">YLQLVTRWIELERSTAWQSPRKGLTTDRRPEALSRWQRKRYVNPEPNLSTPQFVASFSEAFWQWWILLQPKWRAIGPGEKLNPPDFQSTMCESDWQPLDKRGINGWFGLMVCLKWWGQALIFRTVAEQVVLRNEWLRAIHDVSAMLDGLLAFRAAGNIIGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU69</accession>
    <name>A0AA38MU69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1106154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000107">
        <property type="protein sequence ID" value="KAJ3712552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="15"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3712552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="526" mass="57117" checksum="2A194F588B1BC3E8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUB7</accession>
    <name>A0AA38MUB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1009055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000124">
        <property type="protein sequence ID" value="KAJ3711099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUB7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23380" checksum="DC8AFFE566BA17D2" modified="2024-01-24" version="1" fragment="single">MNLPSVSNAGPEDTEENNRNDNASAYCFDLKLKFDSVPEWDGNTDTIVRWLSKINDLAKTSPTIFKQLGSVVPKRLKGSAETWYYSLPLNYRNEAEQTWETLRLIISDYYMNRKWFDNMKKRANNARYRETGYSHETPSEYFIQKNDLLTTVYENDDSLLISEIMSGAPTIWETILTTQVYQTTVELQSAIKFHEETLMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUH2</accession>
    <name>A0AA38MUH2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_272807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUH2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="40210" checksum="EB6ED5D2D374FFFF" modified="2024-01-24" version="1">MFIEALLGTRAQRLFMATLLIQAIVVLVMVGITFRMVDEHVSFTLSGYKTLPCYLALFALAEVFELFMAADALRLRNIIQLVGILLFHLALIVSAALQVHQTRDALINGSVDCSDPTATNYLINCDVPGSLWRKIEPFLIVTPCVIAASWLIMMFWIKQLYGEFGWAIFHIVGANPKTKTMYQYYQVEICLLKFDFFFFTGVTMQLLIVVLSKNSAEFGVTIAAIPIVLGLLMGAALAVRREIKWLMSISLVMMLAAETYFYKLVRFYEPSSRDQYNTTRATLTVFTIVAFLLLFGTFTVGLRCFSDFDRGLLPSKLHGQSYKPVSTKLDFFNNGNMSQRQSSYNGGTMLAPRISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUR2</accession>
    <name>A0AA38MUR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1009110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000127">
        <property type="protein sequence ID" value="KAJ3710919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUR2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="171" mass="19072" checksum="DD623572A3C8B438" modified="2024-01-24" version="1" fragment="single">MQSQGHRVYWKERKNVTVERSVIFAKNENGGLRLEIEMEDDMGVLEREGEKEEIPTEATQFTSNPGSSVLNESSTNEQSSMESPNLLNPSAEQPTQRPIRNRIPSQRVRELLDGTGVSGSKDLLPRGINTAVNSIVDIPPEELMMEACIADVEGVEPKTVTEAKRLPDWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVV5</accession>
    <name>A0AA38MVV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1098161</name>
        <name evidence="3" type="ORF">DFJ43DRAFT_1228587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000131">
        <property type="protein sequence ID" value="KAJ3710882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVV5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041589066" evidence="2">
        <location>
            <begin position="24"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3710882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3718578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="162" mass="17898" checksum="FAC94D5995174ECD" modified="2024-01-24" version="1">MHRSWHLLSLAFIALISVSSVCTFPVELHSGGSPRNDTSTSPPVPSHGTATIRWLEPATKYVLELRQAREMIPELVKQSADVLGLDDSPNNPLKVVYDPKGPSFGNAYRFGWVKFKISGGRETEGKEVVGIIYVGDDDSTSEKWGLGKISFDQKTVFPKNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVZ9</accession>
    <name>A0AA38MVZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1096933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVZ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="109"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3719548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="312" mass="34448" checksum="03E1A0AE085953D2" modified="2024-01-24" version="1">MPTSTMKSGSNLETSTNTLLGLDANNYHEALVANCLDGLPPFEESSYNTSGEPAIKYIQPPNPAWKFGESVESTELGRKWMEGAKFEDDWEHFDAEKEENRKIYTLMISGIQPRPIAFVSSVSATGEENIAPFSFFQALCPSPPLIMISAFNAPRVKDTTANIQATKEFTVNIISLPWIVQANAASIDAPVHISEWEVAGLTKEPSTHVRAPRVKESAFSIECTLFDKYDVVHPDTGVNTSTITFGLIKCIHVRKDVLNARGLPDPAKLQSVSRLGDISYGLTTEAFRLPRPSWASDGETIEKILEERKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWJ3</accession>
    <name>A0AA38MWJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1160048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWJ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="335" mass="37632" checksum="A7FB0918444D1E78" modified="2024-01-24" version="1">MKATIRIMEPKIESRTKNIIKIPKLDLKPSTKRHIRDYENSPSVPSSTTGLVIIIPPAKPIKRGHEVESGEESTLMAVEERPSKRARKVVAFDNLKYESDDLTLTSSSPNTTRKPKTTMRPRNAGKFHPVMPATAGCSYSGLFDIYAMDHQDLCHIYRPEGSQEPQYENLYDALWSDANTDKCTARISLPTAPYGRKFGTALAPVLCDPISERPYDIELTRISHVNQVFYREHERDCFVTRYNSDVSAAGKLPGVSGKTSVSPLGGRDNGVLDSSGNFNLSRVWGKEDEDGKLMEIFEGHMSLRVRYRKNYERKGYGDGFDIGFAFWAIRTNDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWN3</accession>
    <name>A0AA38MWN3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1158351</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWN3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3722724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="223" mass="24462" checksum="42ABFFAC8EB151B4" modified="2024-01-24" version="1">MPDATGPGFDYHDTLIIAHAVFASMAALITAPAAILVARYFRSRTWWFKAHIILQIVTVAFTIIFFTISTVAVASGGHGTQFVGPKKDPHHDLGLAIAILLWVEAIFGVAAHYTHTAHAITRGAFPTIKAKKSPLRHLHAWYGIFVAGLLYAGIKTGIDEWNMVADSGTLVPRGIEIAFWVIFALELAAYVIGWFLEAFRGERKSHMISDHPTDEEKDGTPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXW7</accession>
    <name>A0AA38MXW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_399945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXW7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="609" mass="66256" checksum="3E5B0207E3587EEB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXZ1</accession>
    <name>A0AA38MXZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1085035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXZ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="168" mass="19588" checksum="DE3016FA88B02D7D" modified="2024-01-24" version="1">MIVVGISLFYGEIVSEIFGRCNIERRFHPFQECLSQRASLLIEQSRMRTEKKEPELAEVLVFVRDHHGLFLPRSACLCLYGFILAPSYSGHLDRRFYWSECCSAVRFVLSVGFCVRWLFVLAYATLRVFSSSRPHRNEKSADMEIVTGLWRLVSTRPVKFHILYWGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYC4</accession>
    <name>A0AA38MYC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1003260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYC4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3724188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="192" mass="22081" checksum="BDFC3E280317DBAE" modified="2024-01-24" version="1">MTETRRLLEAASALSRLLVASRVSHAFYGSVFTAVLANAPHCEEIYCIVEGGQHQSHPFRRVRDAIADSEDFSTTLSPWTNRLHVTYRRPIPSIEIEILPAGEAGPRRLDASTVVKIQGIPFLAISEFIRAKLKTWMIRMSDRDAQDITYVLSRYWNRVDINRIPEQDMNFFTTRNTSSQPWWLALKRKYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYH5</accession>
    <name>A0AA38MYH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VIT-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_461619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="307"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3730950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="91756" checksum="5ACC6580FB494609" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYM1</accession>
    <name>A0AA38MYM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1083155</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYM1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041250487" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="18"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="194"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3729993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="562" mass="60096" checksum="C9F8D03585D611A0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ78</accession>
    <name>A0AA38MZ78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1040987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ78"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="199" mass="23025" checksum="9C91379DD2CCD6D0" modified="2024-01-24" version="1">MFSGKSRSAAKTAIEEALHLRKAQDTLRDSIKNLENIIIDGALELYEIAEAEMELPNLQERLDKRLQARKFERDRLERTFRRQLNSLDDSEQTTYLPLWLVDEGVRMGIQGILLRDRCDEELQRLRYELKSLAEWHSEEWTIVNMAIAAIQAVQWTQALAGLPSEVVPCFAVPEGEELIDVQHEVDAELIEDEDEMDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZH6</accession>
    <name>A0AA38MZH6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_376330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZH6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="18271" checksum="EA4496F0C0C6D124" modified="2024-01-24" version="1">MLLQPVFFTLGVISAVCAAPFDPSSNLATPTLAVRAKEKLVKVVDVAFDEWGSTAPAPIETQRGIAMVVFGDESKTTAINWINGYTRGEIHWRWRRRSELQPHTNHLFGWSDKIDIPSTSASGKKLPLVDYEYEVTQILGLQQEEEDRANLTEASLKASGLNGKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZN6</accession>
    <name>A0AA38MZN6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1132827</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZN6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="31"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3730144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="344" mass="36837" checksum="696C51C6A987BC58" modified="2024-01-24" version="1">MSSYSLFCIGNPLLDMQVTNGEQLLKQYELKANDAILAEEKHAPLYEEIVKNHQVTYVAGGASQNAARGAAYVLPPNSVVYTGCVGDDKLAEQLKAANKREGLQDMYYVKKGEQTGACAVVITGHNRSLVTTLRAAEKFDKAHLSSPEISAVLESAKAYYMEGFFLTHGLESALELGQKASKDAKVFSINLSAPFISQFFGAQLQQIIPFTDIIIANESEAEAWATANGHPTPTDLPAVAKALAIQPKSNASRPRIVVLTHGAESTVVVTSDAPDAPKIHPVHALKYEDIIDTNGAGDAFAGGFLGAFVSGKSLDDCVEAGHKMGAMCVQMVGPQFKWPKINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0L5</accession>
    <name>A0AA38N0L5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1071771</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0L5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="7"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3732871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="381" mass="40324" checksum="16F8D9E331BB16A5" modified="2024-01-24" version="1">MSPRVFKIAVLPGDGIGPEVVAEATKVLQVVNSASPDFELKLEEHQFGGAAIDAVGEPLPPSTLKACQEADAILMGSIGGPKWGVDAKVRPEPGLLTLRKTLGLYANIRPANFASEGLLEYTPLRPEVARGFDTVVVRELIGGLYFGTRKEASAEPDVGTAWDNMIYSEAEIQRITRVAAQIALSTNPPMEIHSIDKANVLACSRLWRKTVTETLTKEYPQIIFDHQLVDSTAMVMVSNPRKLNGVILTENLFGDILSDQSSVIPGSLGLLPSASLAGAPSKVSSPDFKPTHGLYEPIHGSAPDIAGKGIANPIGTILSAAMLLRYSLGLDKPASAIEAAVRKVLDLSATGGYGLRTADLGGKVGTTELGDKVVEALKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0U3</accession>
    <name>A0AA38N0U3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1024255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0U3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="281" mass="30847" checksum="E10A88497A781AD9" modified="2024-01-24" version="1">MSSDPSSSLSSLARSKLHKCNLHRWVLLKNSILRSVPTISTPSIDSSDAVQPEAEDEEISTYDADSFMFPDAGKLVDSSGCDNSSEAQWLDSLLETLADDDDDDFGVESGSVLQVDDEYDQMLSPLPSPMSSSDDLTNESYLASSFSYPYLAPYPPLYPPLINSYHFDSASVSSPYIDPLPYYELDDDVADLPVPDAIEDTSDDESDSPLTSSVQSSSSLTLNVPSTSPLPADRPRIVSRAAPHIFIDSDDPSFYPFELGPDPLPFSDDFRSPYNMYQQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N153</accession>
    <name>A0AA38N153_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">DFJ43DRAFT_1068844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N153"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3733381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="295" mass="32034" checksum="B0F22052CA9AA1E7" modified="2024-01-24" version="1">MASKLPPALRETEEEIQLLLAANCHIGMKNCDKQMEPYVWKRRADGLHIINIGKTWEKLVLAARIIAAIENPNDVCVISARPYGHRAVLKFAANTGAQAIAGRFTPGSFTNYITRSFKEPRLIVVTDPRVDHQAIREAAYVNIPVIALCDTDAPLKFVDVAIPTNNKAKHSIGLIWWLLAREVLRLRGTIPRTSDGWNVMVDMFFYRDPEEVEKQQQEEAAAKLAAQAGEEPAAGLAEWDVSSGPAAGAINPALVSQEGATLDWSADANTGPTDWAAEPSGAGWGADASAGNGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1M0</accession>
    <name>A0AA38N1M0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_996559</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1M0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="198"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3732648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="583" mass="66186" checksum="05EAAA4447816ABA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2I8</accession>
    <name>A0AA38N2I8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_196601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2I8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041244921" evidence="1">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="202" mass="23136" checksum="FCE593641B08963A" modified="2024-01-24" version="1">MSQRRRLLFTFLAFLSICLYLFVFSDSDNHDSSIKFFGGFLSKNTKSSVDEIYGLISLVTRESEQSQRVLTTESVDLTQPVDMNVYAAKRGMKWDKELQRLNEEYPVVVFSKTYCPYSRKAKQLLQAYQLSPPPKIIEVDLREDAAQLKTVLTRLTRRSTFPNILLRGKTIGGSDDLHALHNANALRDMFLEAGVDVHMDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2U5</accession>
    <name>A0AA38N2U5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRO1-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1064341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2U5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="3"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="830" mass="93962" checksum="F91DA54FF66F430D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3G3</accession>
    <name>A0AA38N3G3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_130602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3G3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58758" checksum="7999A97478F5F808" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3N7</accession>
    <name>A0AA38N3N7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Glutamine synthetase</fullName>
            <ecNumber evidence="4 13">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1149989</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3N7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="14">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="15">
        <location>
            <begin position="108"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3736260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="354" mass="39274" checksum="1F3AFC3CC438F731" modified="2024-01-24" version="1">MTTSYRNDLLAPFLALPQGDKVQAEYVWIDGDGGLRSKTTTVSKKVTDIGQLRTWDFDGSSTNQAPGHDSDVYLRPAAIFKDPFRGGDNILVLAETYNNDGTPNRTNYRHHAKKVMDQAKDVEPWFGLEQEYTLFDADGTPFGWPKGGFPGPQGPYYCGAGTGKVFARDLIEAHYRACLYAGVNISGINAEVMPAQWEFQVGPCEGISMGDHLWMARYLLVRIAEQWGIKVSFHPKPLQGDWNGAGCHTNYSTKPMREPGGMKYIEAAIEKLSKRHDEHIAVYGEDNDLRLTGRHETGHIGSFSSGVANRGASIRVPRHVAAQGYGYMEDRRPASNIDPYRVTGIIVETTILTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3V2</accession>
    <name>A0AA38N3V2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1222069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3V2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="247"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="855" mass="96813" checksum="C22426F93237607F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3Y6</accession>
    <name>A0AA38N3Y6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_989514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3Y6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="9"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="381" mass="41623" checksum="05DBAE944FB67F8D" modified="2024-01-24" version="1">MASKLLVVDVHTHLYLPRYASLLRERTTLPKIITRTRDDGRKDERLVILKDEPSGGRPIGPSYVERDEKLTFMKKHGIDISIVSTANPWLDFLQPKEAHQLSLQLNDDLEEYCSTGPTVTGTSMKQLYGFGLLPIVSGISTESLLEAVRQISASSHLKGLIMGTRGVGKGLDDEALDPIWAAISEAGLAVFLHPHYGISKESWGAKNNGHVLPLALGFPMETTIATTRLILSGVFDRFPSLRLLLAHSGGALPQLSSRLASCIDHDPIVASRLKHDARFYLGKLYLDAVCYGPEELGFVSDVIARSNRYETGSKNVASGGRSSGSGRMLFGTDHPFFPPLSSSERWKSVVENLDAIENVQGWTEADKNGVKGGNAISLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4B0</accession>
    <name>A0AA38N4B0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1221518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4B0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041299187" evidence="3">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="295" mass="31800" checksum="04F8DE60F9FD0FD3" modified="2024-01-24" version="1">MRYATTSPLQISTAFLCIEAVHALSGPQTEVSCQEVGCAATLHGPEPAGCMRARFWLKSLGMYIKTNCPAGDNSNCAPPIVEASLLVKEKFARLARIQLALLTYYSSPKNTTFIMRLAAMTVFLALFSSACAAVSPTLLNKPLPGLRPPHSQLEGSGRSRSSSRHRKLGVDSIGRTTLHVSFRQGKPWGTPGLNDAADVEARSIVEGFLMSHNDLSNDLGMTLSGKKVQFEDAYPFPTVPARTMVNFDLETTPQAPECSPKCHGTAIKVKEGTFKGKISKDLTGYPLVSGLDEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4F5</accession>
    <name>A0AA38N4F5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1149943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4F5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="303"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="555" mass="61470" checksum="62E66E78CA5C0052" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4N5</accession>
    <name>A0AA38N4N5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1054262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4N5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="11">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3736233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="189" mass="20656" checksum="3B572EB73777D1D2" modified="2024-01-24" version="1">MNRKYVDSRQAAKTWRPKSGSMSPGLKRARAPFLVRNVITGIILGTFAVGVYTYSIRAVRQDDFGDIDDEAKAQREAERLAQLEKMRRESATVLTVGEEKDVMERAARAVAKEINSARLGAPVDEISSLRASQSQSSPVLTEINTRRSTRGVLVGLLDKTLPGVLDPSRKTLVWGAPDVDNVGTASSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4Z7</accession>
    <name>A0AA38N4Z7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Urea carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1199901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4Z7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="3"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="125"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1213" mass="134144" checksum="BE095EE3E3AA7229" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N575</accession>
    <name>A0AA38N575_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora-like Mg2+ transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1129669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N575"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="576" mass="65892" checksum="8AB008C9A4C2D381" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5B6</accession>
    <name>A0AA38N5B6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5B6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="242" mass="28444" checksum="A49AAB7BB31ED607" modified="2024-01-24" version="1">MPNAADTSIRWKKSKRTSIEDRLNQTAAARHVLNITVHTLPSPHLPSASLDKEHLSYEEQKENDPRDAQLEKAKTRSHHLKGQVDSLRKKAVYWEKKAERLKEDKESLEEIVRDKDRVIQGKEREVVEARKKREREVDDWRREAKKRKTEAEEVKKRNDGLHERIAGYQHQIHTLKSRLTRVPERLATVTRRIAHMFNAKTDHDRKFYLKEHGTIPDNARNVLLDLVAMDEVPANKVTHVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5F2</accession>
    <name>A0AA38N5F2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_407798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5F2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="897" mass="97215" checksum="659E311D3CAC92A5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J253</accession>
    <name>A0AA38J253_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1104707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000095">
        <property type="protein sequence ID" value="KAJ3713971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J253"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="256" mass="29053" checksum="405E3B1416082542" modified="2024-01-24" version="1">MASDIIKAVAGRFFLCTLVVPLHFIDVNHIFSMTFPVFGRFSMIFLFSCLLREMFLKASPLPQDSMRSMHAGYKPSFHERSLEHSSEFKTTIDLYLFTCEVHANTLALGATLMTGKVNERWDLLLDPNQGIGPYSPGCANFEYAVVKFSLLRQEVEIEDFTHHPSLFQQFERQDEELRAYRPGLAKISEIPSRLQQTKALLDARDVLLIPASIGKTTITKAVLLKRKAASPPVLKYLRHKTGKSPEEAWSRMSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2H4</accession>
    <name>A0AA38J2H4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_46395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000100">
        <property type="protein sequence ID" value="KAJ3713269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2H4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="232" mass="26519" checksum="079B63D4E6007418" modified="2024-01-24" version="1">MARTMICDARNRPVFSRPRKDRSGETTPATRKAWLESQPSIVNSSVKEHSVVCKDCQNVIQLHPRLCFNIENWQTHVAKECPCLPGREGESEPARKRRRLAKGSEPVMRTHMTLRSRRQSDLREVRTEVEMNRRSEQENFNDDETDVEGVEELRKHPMAVAQSAELTPTCSGDLQFRSPPFKVQGTCNGGEDYTSTSSSSFRFYEYDFTNGDGCEYSSLTSRFPISNERSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2I8</accession>
    <name>A0AA38J2I8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Acetyl CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_1034769</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000117">
        <property type="protein sequence ID" value="KAJ3711618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="38"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="190"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="673"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1471"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="1813"/>
            <end position="2127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3711618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2231" mass="247347" checksum="05A0ADADB9E44C36" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2L9</accession>
    <name>A0AA38J2L9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1107054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000113">
        <property type="protein sequence ID" value="KAJ3711888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2L9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="911" mass="102515" checksum="4B33196D44C5A2B0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3G5</accession>
    <name>A0AA38J3G5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bestrophin, RFP-TM, chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1216028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3G5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3713713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="344" mass="38789" checksum="2B73E200CD5B2430" modified="2024-01-24" version="1">MIIVLHRSSYDRFWEGRKSFATVTSNVRNLSRQIWVNVALPPSDQEDTLSKKGKAPILTASQLHRVKAEALHLCLAFPFAVKHYLRGEDGLNWSDYHDVLPKNFARFDEVGYQKSKTNLTTSYNSISTKSSGRSSPDLGRGDATKRVRPKRSKQNLPSQSTPLLSGAVTHRTVEFRPFADDTSLPLPLIIAHEISHLLFYFRREGLLETVGPAGTNAMNALVQSMVDNMTAMERIANTPIPISYGIHLKQCVTLYLFALPLTLVNDLGWMTIPIVTVVAFTFMGIEGIADEIEMPFGHDPSDLPLDRYCLDLKEEVLYDNDFCPSYSRFRNSVTNVTHPCRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3J6</accession>
    <name>A0AA38J3J6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1104379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000093">
        <property type="protein sequence ID" value="KAJ3714018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3J6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="33"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="388"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3714018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="84885" checksum="9A6B6D158702D376" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4T3</accession>
    <name>A0AA38J4T3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1134321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4T3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3718104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="531" mass="56684" checksum="86C45A2B7DFD65A3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5H8</accession>
    <name>A0AA38J5H8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1096175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5H8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041445249" evidence="3">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3720213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="300" mass="30616" checksum="281900FC17040D79" modified="2024-01-24" version="1">MFTFMIVPIVFALLSSLVAGRAIPIRKSLEGKRSVTVTDFSGGTGDGTYYDAGLGACGITNTDTDYIAAIGEDFFDQYAIHMGVTSGNPNENPICNKKVIATYQGKSVTVAITDRCGGCTNPYSLDFTPTAFSQLADQSVGRITGMTWVWADSDSSGSDSGSESSPSSSSSASDASSTSDSGSDWSSSSSSSSPTPTDASTPAATTTATDTWTSGTNTWTSTSDSSTSTSTSSTSSITAGVVANVGSINNESSSSSGFVTRSSSSVLPTGTGLGGSKPATTQASKQSSGARRSIRRIWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5K7</accession>
    <name>A0AA38J5K7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1008888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000118">
        <property type="protein sequence ID" value="KAJ3711456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5K7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="134" mass="14692" checksum="F8E53856B8019A3B" modified="2024-01-24" version="1" fragment="single">KIRDEGGYCIRCMTEGCAIVAPDDFIHSVLGDDGKETTIALIRFQELVVRGFIALSPKLKFCPYPGCTNTISCPSTPSSFVLSTLVIIASCGARGVLGSGSNKIRRRIRPQHIFCFGCQFESHRRPLRCAVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5L3</accession>
    <name>A0AA38J5L3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1161750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000118">
        <property type="protein sequence ID" value="KAJ3711471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5L3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="254" mass="28750" checksum="6774E2CCC769364A" modified="2024-01-24" version="1">MTYSSPTAMISHLAAGIKLNLRVFLSLRGNTAEDFGDISYWVNVLKMVSFVGQLFTGDTILLLSMLGDIWKNCWVIAAPAIMLVAELICGCFEIYTESTFGPGRSLVVYKQFAPYIITVIVLTVCVNISVTSLIIWRIWSIISNAKKLFPSRTRSPLRCYPYPARFWTDIYELSAGHADHVYCVQQRELPGFRLLQIIGITFNLIIIRVGRGTATRSFDKMSKTPSQLPERRLLNFEKRSLNRGLSTRVARLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5V4</accession>
    <name>A0AA38J5V4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1044652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000145">
        <property type="protein sequence ID" value="KAJ3710125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5V4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="140"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3710125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="220" mass="24416" checksum="CA3B57D5900B9632" modified="2024-01-24" version="1">MTSTGNPFTSSAPPSRGLSDSTYRIPSKIRDFTYAATDPRHQGLGEDGRGTLNIPRENRVRVIFKLLLDDAEYQAWKAAAVSADADVSDSDDVHEDENEDGVETNDEEYINRGWDGHWTMPSEEPDYDDDEEEGRADGPLSPGLYRALYPFVPEDPREMPLKEEQVVRVVGRGGGSGWAVVVVDGVDEKGKRRSSQKDKQLALVPESYLEPIALDDSEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J606</accession>
    <name>A0AA38J606_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">chitin deacetylase</fullName>
            <ecNumber evidence="12">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1173231</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="12"/>
    <dbReference type="EMBL" id="JANVFO010000154">
        <property type="protein sequence ID" value="KAJ3709880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J606"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041342024" description="chitin deacetylase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="16">
        <location>
            <begin position="111"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3709880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="423" mass="46302" checksum="7ED5736AF584A4BC" modified="2024-01-24" version="1">MRLTVLSSKFTPDAVLVFLINFSAVYARTATSEADEAQITDPVEEFTSYYYAPVTDALDGFPTIWQPATIVSNDTEAQNIWANISQSVPTNIFPHPRIPTVGGRSLCTTPKLSTLPSDVASIPEKASAYLKFLRSAPVHLAVAMFFIGSNVLDWPYEAMRAIDEGHEICALTGFSSEDAFAELYYSVRMKAIKLVLGVTPTCWRPPFGDVDDRIRAIAEGLGLQTIIWQYDSFDWEEQSGNITAAQVYTNYDNFIARAENGTFNTEGSIMLTHELNNFTMQTAVTLSQIEGYFQSYVETNYSLPTFDEYISGNVTTNSSSSSSSNSTSSSTSQSSSAGVRLIQTISSVLLASITLGILMLAALGMSEDMIQAKWALLVLVSCIDGTMLPGRARVKATLVSAITRRKSLRNALPGERKAPRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J697</accession>
    <name>A0AA38J697_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1167177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000112">
        <property type="protein sequence ID" value="KAJ3712094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J697"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="86" mass="9500" checksum="95550CD662A617A4" modified="2024-01-24" version="1">MTVLSGLRLCRTTYGIDVNFVDIDSDDEQEDGSPEALAEFNSQIAKLTAGIKCIAPNFTKAMERLNGVEQKLAETEAETEKARKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7Z7</accession>
    <name>A0AA38J7Z7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1133279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7Z7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="396"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3726492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="486" mass="54486" checksum="037E56A969CC1AEF" modified="2024-01-24" version="1">MWKRKIEEPRRKVKAVCTSSRVPIVLTIIFQCFLRAELLKPPDSPNGVSVLQHDLSAHTATRPGDPTPVSRNLNPLMHPFSRARERTRALNAAKMDRMFAKPFVGALEGHIDAVEVLAKQGDSLSTVASGSWDGGVMVHNLSQRTHIARLPQAHKGKVTGLCFAGDSRLLSCGVDRNVKLWKIASDEPLNVFPGKYAFNSIDHQRSSSLFATASTLVQIWDETKSAPISNLTFPTSTETISSVRFNLSESSILASVGSDRTFTLYDIRTGKAERRVVMQMRANALSWSPTFPTNILLASEDHNLYAFDIRRLNAPSLIYKGHVAAVMSCDWSPTGTEFVSGGWDRTVRIWQTGQGHSPEVYHTKRMQRVTSTLFTNDARFVLSGSDDGNVRIWKGKASERLGIVTARERAAIEYRSSLVDRWKMDREVGKVVRTRHLPKPVYAANKLKNTMLESRRVKEERRRKHTRAGESKPKSERKKVILAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8J5</accession>
    <name>A0AA38J8J5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1139908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8J5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3728981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="52518" checksum="CC29A43D2139A80B" modified="2024-01-24" version="1">MVATISPPLTSSSQFISSEKLNEWTLLGGEPLKDTPLCATMEIHELKNAPIMTRDAFSRCESSTTQYGVLGRVLGCYSKKEISTFQDSRVYLNTNTPMSALVCGVQGSGKSHTVSVILENMFISSSLLGTLAKPLSGLVLHFGEGGPGSGPCEAAWIGVSNHSSIKAPPVKIYVSNSSLNTMKGVYAPLTQKGNVTVAPLLFNESELDAEAFLSLMAVGSSDNAPLYIQTILSILRELGESFSYQAFMTALELKKKTFNPAQLAGVEQRLSLLNSFMAGKKTKKLRWEASTERKCRFSPGELTIIDLSDPFIDPASACGLFEVLTRLFVRADVGTGKVLVVDEAHKYLSSSQHPSGFTKALLSLTRQQRHLAMRVIISTQEPTVVNPVLLDLCTVTILHRFSSPAWWSHLEKHVSAEFSDNDAFDKVVRLQTGEAIILAPSGLATFTSNTNEHNVGQIGRRYLIVKTRKRVTVDGGASIRVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9B2</accession>
    <name>A0AA38J9B2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1005296</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9B2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="36"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="258"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="709"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3719596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="758" mass="84019" checksum="3892137150DCE9EA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9E6</accession>
    <name>A0AA38J9E6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_998543</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9E6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="290" mass="32171" checksum="18A441B0A2A3C5DA" modified="2024-01-24" version="1">MARLSPFASLLLLAWLTTTIEVVQAHVAAWHYAMYCLNGTSRYDNPNTNDAIQPLYQMTKDDWWFHHNNKCDQFPPEEGDFLDLPVNGSFTVELALNRAFTTLSYNGEDIGEFGDGEDHPGMGEDGDCITAINIHTQNESMAAGTAFAISYQSNMSLVTFENLVVFTTLYHTPWKRIATYSVPNLPACPPEGCICAWGWVRNSLWPCGTANMYHLGYRCKVVGQTGDAAVAPGQAPVWCEDDPDRCVKGAKQMLYWHQQDGNNIEVEGLDLAGDHKSPAYNSKCGFKNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9F0</accession>
    <name>A0AA38J9F0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1008704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000114">
        <property type="protein sequence ID" value="KAJ3711854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9F0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3711854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="224" mass="25338" checksum="2AC021F60C41E1D7" modified="2024-01-24" version="1" fragment="single">EKAYYNTSAHFLWIGDRTRQLDGGHVEYFRGIKNPIGIKVGPSMKDDELVRFLDTVNPDKVSGKVTLITRYGAGKVENYLPVHIKAVKLSQHPVVWICDPMHGNTLTSSTGLKTRHFHTIIDELTSCIRIHSECDSRLGGVSLEFTGELNDEGFSVTECLGGSMELSEEQLGLRYQTFCDPRLNFEQSLDVAFLISKHYKDERRGKQKRTCAERSRVESQSTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA70</accession>
    <name>A0AA38JA70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_787314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA70"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3717607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="231" mass="25470" checksum="F80884BEC4CAE57B" modified="2024-01-24" version="1">MSIAQNFVKHGKKIIAIGRNYDAHIKELGNPPNAEPWFFLKPTTSYLKNGGTVLIPEGVQMHHEIELGVVIGKDGKDIKREDWEQYVAGYALGIDMTARNFQQFVKAKSLPWTSSKGFDTFCPISEFIPKEGIKDPMNLVLSIKVNGEERQRGNTADMIYDIPELIRHCSSIMTLQEGDLILTGTPAGALGLIVHGDKISGRLETPEGELLANWDGDAANRAGGYVFTQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA98</accession>
    <name>A0AA38JA98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1154178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA98"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="759"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="980" mass="109335" checksum="3060F8550B01B589" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAC4</accession>
    <name>A0AA38JAC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear protein 96-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1104493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000093">
        <property type="protein sequence ID" value="KAJ3714029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAC4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore complex protein NUP96 C-terminal" evidence="2">
        <location>
            <begin position="365"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3714029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="858" mass="95300" checksum="3A38CE63BCCEFC1A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB25</accession>
    <name>A0AA38JB25_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_739237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB25"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3719559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="614" mass="65407" checksum="0FA15A29F1A8E326" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBT6</accession>
    <name>A0AA38JBT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_714569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBT6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3720809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="354" mass="40470" checksum="0B2D51BB4A88BAE4" modified="2024-01-24" version="1">MSSSSKGSHLIRYYSRLIETYIQLSLYEEAEATATRVLTVDPSNLTVRLKRGHSRRRIGHFVGALVDFETVLSIPPKLDTAQVLHHDEALRQRDIVVNTLGCSYAELTRTHPIKIEDYNQPALSRVSLTSNEEKPITQVFLDEPLPTNCRFYNHLGCRRGKKCLFSHAPDARSIRDDLGKNVCLYHLIGKCKWDSFSCIYSHSKDNLPSEYIIDEDTSKPSWWTDSARVRAVRELVEQRDARRKKIHEQSERARQQNTDKNKSKKKKKKKKDSDDKPPPNANPDTVPPPDSFSSTNSNCDETLVIDWESESDSDEELEFEDVESTGSDILSYGNKPWEHEEAKALVVALDDLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCE0</accession>
    <name>A0AA38JCE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_997417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCE0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000583">
        <property type="entry name" value="MAP3K epsilon protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052441">
        <property type="entry name" value="Armadillo-Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="735" mass="81289" checksum="863A42749C886425" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCR9</accession>
    <name>A0AA38JCR9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1044394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000121">
        <property type="protein sequence ID" value="KAJ3711278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCR9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="106"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="362" mass="40524" checksum="DE6079AD07CA0DD5" modified="2024-01-24" version="1">MMSAGDDDEQEEPAHRTVPNIKKASKAHDAKYAAELPAMVAPSMERNIQKSKGKSAAHSGGSNGNDGWPASTSLVYPQQQRVISLTAQSQTTRDLIHEAILLAIGLAIFQNGFAASDQQLVDSRNSLITAAMKRQLPEIVDRYERDSVYARHLTNYVTGRVGHMRGKVKDAAQELVPAMYGIHLIPVENNARKNFIASLLSKMNYIFPRTNLVESSTVRTNEPYRHPAIVAVMRKYFFTGNRSLGRRFQDTFSSSIDSDNSKEIPRALLGIVVVAIFAALKEWHEGLDQRQNQDFVSADFSDEYELHMALLQTKIYRNDGTGKVKYHVLMSRLYREVTMDSGHNVLASSEKMPDVDFDGMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCX4</accession>
    <name>A0AA38JCX4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1152230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCX4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="586" mass="66172" checksum="AE8C04B22491F9B0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDP7</accession>
    <name>A0AA38JDP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1135150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000123">
        <property type="protein sequence ID" value="KAJ3711122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDP7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="9"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3711122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="347" mass="37690" checksum="30662EDE596F1235" modified="2024-01-24" version="1">MSFMNKAWGATSPEKTEPITITRRAPDDQDVGIDIKFAGICHSDIHTVRSEWGKTTYPLVVGHEIAGIVSAVGKNVTKFKIGDHVGVGCMVNSCRQCENCHDGEEQYCFSGTVFTYNSKDPKDGTITQGGYSQHVVVDQAFVLKVPESIPLDKAAPLMCAGITLYSPLNHWKAGPGKRVGIIGFGGLGHMGVKLAKALGSEVTVFSQTNSKKELGLRLGADDYVATSDPDVFSKLSRKFDLIINTVSASIPLEMYLSCLRRDGSLVQVGAPEKPLLISPFSLDAQRVGLHGSMIGGIAETQKMLDLCGEKLIFPEIEIIPASYIDEAYERVLKSQVKFRFVIDISTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JES4</accession>
    <name>A0AA38JES4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_536976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JES4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="437" mass="47835" checksum="682AE7082F7639FE" modified="2024-01-24" version="1">MRVNAPSAPVRNLMRKRPSSESEDKSLSAKRAKQTDIGGLKANWKPLVYGNKTPSTSAFHEVSTEIEFEEIAGGEFEQDVAKEVVDAERAGKSHKKEAHTSKEVVEVKLEPADVNVIANEERETGKPAQPKPRATVKVSDLPFGLASDRNIWNSAVQSSLIEWSGSRAQQFSLGSDPEFRPTLRNLWNEHLAILPHLLPNTTDAKGQTILRCDHPAINSQAQTQIRNYRSKVGQRGLQAVIGYLQANAKGAEAEKQLVVQLRHKDSFIYEKPGSMPASSTGAFRGALIMRTFAFYLTWALDAPTIGEKLPAGALALATTAVYRALDVCKNGIPASDQKTMPVSTRPGRNTPDSFNEEWAPSCQRFYNLIIKLKDDKWDLIFAASEGYIPDLPNAGAGPALKRIRAEAAAQLGHWQGSLGGGRTARTEDEGETIILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF41</accession>
    <name>A0AA38JF41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycosyltransferase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_105822</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF41"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3734816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="753" mass="85506" checksum="D6BF20414E03C815" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFB6</accession>
    <name>A0AA38JFB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1059781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFB6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="51"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="843" mass="89672" checksum="99225B361F46B7CD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFZ5</accession>
    <name>A0AA38JFZ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1081259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFZ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="324" mass="36633" checksum="206F8F6BCD07538B" modified="2024-01-24" version="1">MAIIDGSHGGDEISQLWAVITELSEQLNQNRNASVSLHAQAGGVKNQALHSQTGFVLRRFNLDKPKEIYDSELERMNTTITAENQSLQHDNKQLNTLIKEYEQTLDTLMSTFRNRAQTVQENELSLIRHYESHLLQLEEGNSSRELEASTKISESISRLSEVLRNCLREVGGERTRVARRDDDEDDSGSEEDPDLFEREPWQSTDATHAEWALEREIELARLERENEELRTLIIAGQAIPLRVSHEAHPALSQTQPRTEEPSQTGERVDSAAEPETKVEEDKDSSIQDQSPPQTHVAEDLDTVPEGDLSNEDPYATVKRSKMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG34</accession>
    <name>A0AA38JG34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1000738</name>
        <name evidence="3" type="ORF">DFJ43DRAFT_1000895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG34"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3729195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="168" mass="19452" checksum="91A7931E20A3CB15" modified="2024-01-24" version="1" fragment="single">LIVPWLLTAWYGIRYENRTITISFISVASLFILASSFMFISPIYRWTFYAWPCLGCFITASLILLIATVVLGSVCLRNFGKGLAQYLYASSNLSSSNFTRGVFERDVERDVERDGDDDDKDEDEEGKKQRKERKEKEFESRLGREEQGEGEDFTTRYLHYLPTLARVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGH8</accession>
    <name>A0AA38JGH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mechanosensitive ion channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_127754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGH8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="770"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="686"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117126" checksum="28D011C0EDB97ABA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGS1</accession>
    <name>A0AA38JGS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-glucan synthesis-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_992941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGS1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="204"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3734664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="630" mass="68866" checksum="18A70741FEE4AE72" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH78</accession>
    <name>A0AA38JH78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1154128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH78"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="547" mass="59121" checksum="110DD6F3EF0C3312" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHA9</accession>
    <name>A0AA38JHA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1000509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="101"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3729937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="547" mass="61133" checksum="87BAEC8AEC963CCF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHY2</accession>
    <name>A0AA38JHY2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_609427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHY2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="130" mass="14794" checksum="A489ACBC58BF4CF3" modified="2024-01-24" version="1">MPYLFPYIEANFNVSQNPDRRGSVGLSEGSNLVYEMYINSTEITLLTLGMFQEQLVLPAGALQYEYINASLRQILFWQRRALSCSSDYMTSRLMTPGIYNMRWICSTSDTLSNLFYTVAITGKIRFGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI27</accession>
    <name>A0AA38JI27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1199568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI27"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="262" mass="29521" checksum="58F03E61CF75F20C" modified="2024-01-24" version="1">MSSPAVSLYLDPQIRDWVLFPITLILVGILRHYVVLLLQSPPKKLPKAAIREQRALSRSQILRATSANSPIPPSYYRSISSRLHTAFEAGTYLKDGPPQGDAPSTPANPMTDPAAMDGMMAGMKTQMVMMVPQMVIMGWINFFFQGFVLIKLPFPLTLGFKSMLQRGIETQDMDVRWVSSLSWYFLNFFGLNGLYRLILGNDNYTSQAMMSSPFAGTNQPGQPQDYVKLFKAEKDNLAFSEGLYSWLGDDVETRLLRKYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI92</accession>
    <name>A0AA38JI92_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1089877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI92"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3724934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="416" mass="45194" checksum="99193E18D2B3BBA0" modified="2024-01-24" version="1">MTQTTLLQYEAPWPVYAMDWCKTPSPKEQMRPRSSFRLGIGSFLENFSNRIAIVGLEDEHILVEDDYTDYPDFVTLCDAPHGYPVTSLQWQPASAISYQWSQKSPSTEFLATTGDALRLWEYSGDASPAMSNFVGRTPSSSGHSLNLKSALSGQSKVQNNSNGAPLTNFSWNEKAPSLIVTSSIDTTCTVWNIDTSAAVTQLIAHDREVYDVAWLPTSTDIFVSVGADGSLRAFDLRSLEHSTILYETPAPKNVPPPSVSPSTSARPPTSPLLRIAFNPSDSNYMSTFHMDGSEIQILDMRSPGQPVLELKGHHGQINAVGWATAALIMDLANHTAASASMNANSPRSASSRLNSPRPDVKKKYVNEPAFAYTASSQITNLAWSPVIQGLNLSTGQSTAGEWVAIACGKTMKALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ22</accession>
    <name>A0AA38JJ22_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1129703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ22"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041442280" evidence="2">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="261" mass="27217" checksum="FF7419F6A8538E29" modified="2024-01-24" version="1">MKLSTFFVSSALLFSVVVARPSRLAERVAARESRRSRPFTASTSNTVLAGNVSHAEFSENWSGVVIESPPSGQTFNKVVGTFVVPTPTGNSGAASAWVGIDGDTASQSILQSGVDFTVSGGRVSYDAWFEWFPNFATDFSNFAISSGNTITVTVQSTSSTRGTVTLTNESTGKTVTQALSAPDSAAALRGLNAEWIVEDFEEGNSLVPFANFGTVEFTGAAASTSSETLTPASGVILDIEQNGEVLTSVTSSGSTVTVKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJY2</accession>
    <name>A0AA38JJY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1069041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="852"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1284" mass="136802" checksum="FFD9AD0F7865504F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKB1</accession>
    <name>A0AA38JKB1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1132892</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKB1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="35"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3730028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="434" mass="48175" checksum="5616BEED6B4BD10B" modified="2024-01-24" version="1">MTTTTENLTTFKPTTRKLAGYQFYREVLGSPKYVVAPMVDQSELAWRRLSRRYGAQLIYTPMINAKIWADSTNKVIRNAFFDLETGEEGDPTADRPLIVQFCGNDPEKLLKSAKALEEHCDAVDLNLGCPQEIAKKGKYGAFLQDDWDLIYKLVNILHVNLSIPVTAKFRVFSTVEKTVEYAKMLERAGAQILTCHGRIREQRGQNAGLADWAKIRAVKEAVSVPVFANGNILFQSDIEVCLRETGCDGVMSAEGQLYNVALFSGLTSDPSSTSLPFTSTVPEHSSTTSSAPLSETDKPTALPPLNLSQHPRHADLALEYLDIVKSLKTRTSVSAIKGHLFKIMRPALSRETDLRERLGKVTIKKTGNFAEGALQPYVDVCLEMKERMDRDAKGAEGKSLDELVTIDEATGLRILPHWLTQPYWRSPKPAPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKP4</accession>
    <name>A0AA38JKP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1152833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKP4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="834" mass="93941" checksum="AC09D8C19E892F1A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL82</accession>
    <name>A0AA38JL82_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_181094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL82"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041282774" evidence="1">
        <location>
            <begin position="30"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="228" mass="25983" checksum="1AB3856A82B326E0" modified="2024-01-24" version="1">MRPFSSITNLFSAVLPFLLLDVLDYKANASIMRSLSETATSSSASQLNGRGQPLVPRMTIGYAYWHEAQCQDYDIKALWDLSRAYVVLSPVPKYDAEVYANVQDGSCEVRNMSGTVSKLVIYLSPQCIFEADKDQVLDSKMQYAFPPRGKTLESSTITFLRHRYRIPGMVLKRGNTKNLNIRLELRAVEIIEWNKWPITDWPLGDDSKNKTIDAFKSEWEARNPNPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLF7</accession>
    <name>A0AA38JLF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1064210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLF7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="170" mass="19292" checksum="0D2764A9F94D9A17" modified="2024-01-24" version="1">MTSSLAKTELVIRLFLIFFGFFSVIANNWHLMSCTGTVPATSPCTTPTCELSPAINCSPFDPHIEISMFALMMQELHVPKEPRYGSDANRQNHDSKDARVLMDRGFFVFFRECTVEHPKCDCIAQNLLTHPCPPRVTKVGETPWPYGTHECDLRRNNRSGLLSHMTPFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLK2</accession>
    <name>A0AA38JLK2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_369092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLK2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="226" mass="25333" checksum="D0A84E8D69FE005D" modified="2024-01-24" version="1">MHSKYFYKFSQSWRYPGFDYGMFRRAHSHRCGPSRLLWFSIGAASATWYIMHKEAERSSRATYWKNCYRPPIQQPQSQDNRDLSQVLADPLPTVPGSGSGASPTPSSYPYSHPHHHSHWSWGFAKERSFQYPPPSAVPPSNGLVNDNNANSSTNGQVLSDSARPIASTESLSASTPIPVVAPPHSAASAVQAQAVPWGFESRFEQQKKEWEQEREKLLAKAQDTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLM2</accession>
    <name>A0AA38JLM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_29786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLM2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="671" mass="71441" checksum="28E764A488211881" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLX9</accession>
    <name>A0AA38JLX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1295-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1075703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLX9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="287" mass="32277" checksum="F4BF313616C6AAA6" modified="2024-01-24" version="1">MAVFSRILPPLATSYAVQAIFALIFVPQRNEKYYDLGGAVGFISTTFASLYYPALKENFIQGKLLPLPPLSSFAPRQLMLSAALGVWITRLGSFLVQAFKAGGDSRFDEVKHKPAQFTFYWLMQASWVFIVGLPVYLANTIPAKAHPPLGSRDYISFGLFLSSFCFEAIADHQKTVWRRKKDAKEHDGKFITSGLWSISRHPNYVGEVGIWAAIWSLSTTALQTPYFPRGTVAIAAISPIFTYFLLRKLSGVPPLEKAGDQKFGADPKWHEYKRNVPVFWPWSSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM09</accession>
    <name>A0AA38JM09_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1071808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM09"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="603" mass="68396" checksum="0CBB9CB70369DC5C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMT4</accession>
    <name>A0AA38JMT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_174143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMT4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="192" mass="21522" checksum="89D0F1F09634FCF0" modified="2024-01-24" version="1">MTMLINVNNCGAHETGIYSPSAHQINIKLSEFDLFIYSSSLLLDIMDSDENLPTEIIQKLLWLRTLLKNLPSALPTPQRGEIPKYPFETFRPDAAHLQKTEDEVGAINEGFKSIFGWKTRTTGDGIIPIEERGKHGIGAVADLLERYLKKYKDSSGQPNAVLVKWVEDISTGCEKAIKKHGKEVSSMSEYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMV2</accession>
    <name>A0AA38JMV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PPPDE putative peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_995645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="207"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="351"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="668" mass="71785" checksum="B5C44C73B351E07E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNN2</accession>
    <name>A0AA38JNN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1223390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="937"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="887"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1300" mass="146160" checksum="0AC67DB9D63D6D15" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPT9</accession>
    <name>A0AA38JPT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspergillopepsin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1055636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPT9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="241" mass="25694" checksum="2EC9390A3259649D" modified="2024-01-24" version="1">MKLLTTTSTIILLVSAALARPGSSINERVAGRRRKSQPKITSQSPAIETNSTFHEEYSENWAGVFFESPPSGETYSAVSGTFTVPSISGNGGASAWVGIDGVTYTDAILQAGVDFTISDGSISYDAWYEWYPDAAYDFTSFDISEGDSITVSVEATSDSEGTITLENITTGQSVTQAVSAPDSSTVISGQNVEWIVEDLRRMARSSTVDLTNGDIVDITQDSEVLTATTIESSTSITVTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPX1</accession>
    <name>A0AA38JPX1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein BRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1136292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPX1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="59"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="316" mass="36013" checksum="DD113EEDB84DE688" modified="2024-01-24" version="1">MGSILKAQKANASKAARAVDRKGKRKADDMMALDDSDSEFEEKQELEAVPATKRRKNKQRVLLLSSRGVTHRMRHLMNDLEVLLPHVKKDSKLDSKSQLHLLPELADLHNCNNTLYFEARRHEDLYLWAAKMPNGPSIKMHVQNVHTMDELKMTGNCLKGSRGLLSFDKSFDDTEWGKLTKELFTQIFGIPPTARKAKPFVDHILTFSVVDEKIWFRNFQIIEKDPLSLNGPPQMTLVEIGPRFVLTPIRIFEGAFGGATVYSNPEFITPAAIRTAIRKEQGKKYNIRKDAEQASSVRKEKRRRAEDELAVSKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ69</accession>
    <name>A0AA38JQ69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1052154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37320" checksum="35C9D6D6DD02576E" modified="2024-01-24" version="1">MEITNWDSVLQFASGNMDLNLQEHDFSEYSTSSSTPNLQVPTPPHSTDGGGSPVCDDPSDHNVLVSISTTFYPGANLHSLPPDLALLSSDSVFFYVHSHIILAVSDNSFLSLIPTSSSKEHSNNMVIHVPELSPVLNIILHIIYDKSCSHYSPSLETLSAAVNRLPSYGIDSKSRITPSTPIHTLLLSHAPLSPLEVYTLAAKHDLYDLAVPTSSHLLSFQLSTITDDIAEAIGPKYLRRMFFLHIGRSEALKRILLQPPHPHAPTPWCDFTNQKTLTRAWALASAYLAWDARPDISTGFLEAALAPLAEHLSCDLCKQGLNDRIKNLIVQWSVVKRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQP8</accession>
    <name>A0AA38JQP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase phosphorylation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1064383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQP8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="280" mass="32417" checksum="AEA074DDD98A366D" modified="2024-01-24" version="1">MFEPIRGGTRGGQAEFKWTDVSADKDRENYLGHSINAPTGRWQKNKDVHWYSRDSNDSELQRQEEIKKIKEAEADALAVALGFTPEPKSSKIESGTATTSTNTTTPATGTSTTDEVSPSGNIPVDPQRLIEKEEKRKRKEDRRARKEEKRARKEEKAKRKVRDRDYSSDYQRDRGHDYADFNRYPDDRLHRSERRKDKDRGMDRHRDRDSRSRSPTPRRTSRLPPRRSPTPTPTPRDHPRVSGRQGGGGGGGGERSRSRTPSRWDRDHERTGRRENESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR08</accession>
    <name>A0AA38JR08_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shr3 amino acid permease chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1077263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR08"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="176" mass="19229" checksum="D9D886E8A952858A" modified="2024-01-24" version="1">MTFKQAAVLAPVSFFLGILFICFHVDYKLLWGELNEAVVADGFSFYATFFNSPPAIKALLHGMIGVGVLGLVAKLHKWDDSAMFFDGSSLGVYVFAIAVYTAVICPTMKTVVIPLEEDTYSDRIEAVRVLAAANVIIMICLGLLLTLQAGQVYAKRLEVQAAEEGTKAVEKEKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRE2</accession>
    <name>A0AA38JRE2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_381799</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRE2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3736864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="522" mass="58120" checksum="B738900B76DEE82C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRU4</accession>
    <name>A0AA38JRU4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1136654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21366" checksum="B6251177CA9FAE03" modified="2024-01-24" version="1">MSSNIDAIAGPSTTLVTPPAAVIHESTSSSTDSPISPFNAFFGYTLSQTATRESQHDRPLSSSSFSSESELLPPAYVEPPAYETRQREPTTLAMFLFKFGFLFPPFWIMGALILLTPLRAPEDSYSSSSSSTSSLPAAWLPEKTPAEKQQIISTMRSVEVKWAWRCLIALCILIFSVAAIVSLAWGILKVTRGLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRW2</accession>
    <name>A0AA38JRW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1035236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRW2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="301" mass="33329" checksum="55F64994D75C9F71" modified="2024-01-24" version="1">MGATSKNPDLDSGLHLSLSDCRNVANNTGTSTLDPHSKFGAIYAFAVNFVFSRRRFLSVILKTGSTDSWTGVALWIQLNYHQETYFHQNEFLASISFFLVIMAANINVDAIALDAKLACGVPWNIRHEEGTPCKFWGKDESGTHVHDGTCKKRDGFHLIHSLECTTTSVDLEEVVTIQREIKGKEQLGIHQCGSMGVEAKAWIPGPGQLFLNLSSSSTSDTSSYVELEVTGTSEVESREQEENAEDEEDSVNVLERFKLLVTVPGSFFKMSEGVFPERSRQEGGPEEGYKNLERIAESPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSI7</accession>
    <name>A0AA38JSI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1148605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="33539" checksum="881553BF1DDEE7AD" modified="2024-01-24" version="1">MFIDSVRFARADTTTSSASSLTTSVSTSNSTPTSTTVTSSGSSSSSSSPSSSASSSTASTSTSSSSSTSSSTQSTSITSSASSTSATASATSSQSSSISNGKEIGAIVGGVIGGLVVLTLLSVVFTALRRKRRNAKKRPRGSVYLGNMDQNQLDTFLKQKPRTNVDSLHSSSSMPLLSLPQMDTTLQHDIATEYTDVPAPNSYRDHQPNTTQGNDQNGTGGESESGHSLFLPSPYSQHGHDGNDDDVPPELPQPRLMTPSLRPESQFYEPIPVQVGDFSMKALEESASGSRSSTPVSLSMMHGKNGVNITSSPPVHEENASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTX6</accession>
    <name>A0AA38JTX6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1053589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTX6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="179" mass="20492" checksum="941C0321DFA9DA09" modified="2024-01-24" version="1">MGSNQICAAYIALLHRRDQEGSVPTSFHWVLCYLPRSDDDTTQGFYIYHVLDESEAWEQSKHVNPVHIEQNDRFHIVIKLGYVLADINTVTDFTASQPATQDDTPLLSTHRNWSCALWIIRVLADFQEAGLFSAIPLQTEDDKMKFYRRIYSAGALASGYPNSDFPVVYHGEVKMTQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU39</accession>
    <name>A0AA38JU39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_707969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU39"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="519" mass="58986" checksum="B863173D4784BA0C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU91</accession>
    <name>A0AA38JU91_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1128664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU91"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25500" checksum="A110CA39F88D6C40" modified="2024-01-24" version="1">MSSHMLSSRLANLKVREAFLVTDTEDQTSFEGVPFANVTLLSSKRFAFDLASQVERGDKFMLGPISRVELPSKYGRCAFSVDIIPPSIPSIPAAAYRLVNVHLDSLGHTLPYRTKQLEILANLLREPGCAGGLIAGDFNAISSDDHALLNKNGLVDAWVALHGEEGPDEATWGVEVKREDGLGAGRLDKVAMLGIEAKGMEIMRPPLIEVTKPAEDSDYMPCSDHYGLRLCFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVV7</accession>
    <name>A0AA38JVV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_255774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVV7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="81377" checksum="1DB19B11CC34BD86" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JX14</accession>
    <name>A0AA38JX14_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DFJ43DRAFT_1049140</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="498"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="775"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1350"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="261"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1551"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="580"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1577"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1595"/>
            <end position="1604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3737090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1611" mass="181573" checksum="7F9B9F312FBD79FE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JY02</accession>
    <name>A0AA38JY02_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_346</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JY02"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="14">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="15">
        <location>
            <begin position="210"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3737480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="420" mass="46436" checksum="AFA7AC33B82EC474" modified="2024-01-24" version="1">MVAEDPPQVQDSNALSDSDVLDVTQELEELAIDFITQLCRATNTSKNAVDATSSESEGSSSNKPSIHLEMADRTRTSPVTGSYSSRFITFPKRSSNASVKLAQLFKVVDSMHEAVIERVPVTKRDIYYRDVPLFKDQRIVDTIVDDVAASLKLERSDLNVRATSKGIFCGSTLSIYLSSGDIVCGNDSEASLIPVGEEVKTFNVDEDLAWVLIVEKDAVFQTLRHLNASNHPSLPGRGLLITGKGYPDMATRHLVKSLSDSLPQTIPIMALVDGDPYGLDILSVYKYGSSRLRHENNKLAARRIEWMGLLSSELAGFGIDKDALIPISQHDEKKALSMIQRSQDVMPAKWRKELVHMLHTRRKAEIEILSSPVSSTPVSSRGCALLPSSVAEDDTFQRAPLLKYLHIKITQFVNSARKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JY74</accession>
    <name>A0AA38JY74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1135477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JY74"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="303" mass="34388" checksum="08354D19A0B68FDC" modified="2024-01-24" version="1">MRCFFSILPYLCRFTFISPHRWPVSVKTRSLPKRYSAPAMQLLLRPVLFMGLLFIVKTFATPVCTRALPSSDSNSGFCNVGKVPANSPSIHSRALDGTKKVIETRLTLYAPFWPDESDISEEFAVKIYNATQIILPLLVPVHPISDSLNIPVNSENLAFKVNEFLYFGTSEDNDFSLVVDLSHNGQKIDTEIRFQQRTFQSQSLKAGDLFGYATYRRHHFLRETCFKFRNGFYQQPGDEYMTRFPELEITKVRAVKARKYDDLVFTFEENPDQDKKSGQSVPDLLKKAWGKMGGRGGAGPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1T6</accession>
    <name>A0AA38K1T6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_408642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1T6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="236" mass="26664" checksum="E8F05564DA57B5B1" modified="2024-01-24" version="1">MIQTLYIARHGFRSSWSTGDRTDRNDPLSELGLTQAQDLATYLASLAEDKRPTAIFSSPFKRCLQTSRPTSNALGVPIYVDHWISEWYSDLTAGKGVKQPEPPNPSANILKEDFPEIDADAWSNLWYPPSTGENIAQITDRMSTFLSRFIPQVETTLSPEKHERILIVTHAAPVIALVRNLLRETESRVKPGCCSISEFERNSNSDSKEVEWSPKRVGDCAHVSGDIREWGFEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQV5</accession>
    <name>A0AA38MQV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1134797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000089">
        <property type="protein sequence ID" value="KAJ3714639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQV5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="59"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3714639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="449" mass="47160" checksum="70BCD0AA2647F4AE" modified="2024-01-24" version="1">MLSFLPSALLALTLPQFIFGQPKCGLVPPRDATASSKSTSTGTGTGTSSSSGDDDIADVLANGWYPGWLADDNPPSNISWNKYNTLTFAFATTTSDVNTVALDSISQQALPQFVTEAQAHNVTAILSIGGWSGSMYFSNAMATAQNRSAFVKTVLGLVEKYDVNGIEFDWEYPAKQGIGCNTVSTSDSENFLSFLQELRKDPTGAQLVLAAAVSITPWVGSSGEPMTDVSAFAKVLDHISIMNYDIWGSWSPTVGPNAPLNDSCAPIQDGSAVSAVKAWTSAGFPADQISLGLAAYGHSFDVSNSNAISSSNSKELKLYPAFNAGDQPHGDSQDGQAGTDECGNSTPVGGIFNFWGLVDGGFLTTAGTAANGIDYIFDNCSQTPFVYNPTSDVMVSFDDATSYAAKGKFINSMGLKGFSVWHILGDYDDILLDAVSAAMGIETVCTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRM1</accession>
    <name>A0AA38MRM1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_728695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRM1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3720218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="523" mass="56243" checksum="BEC2BE1B3ACA66D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRM8</accession>
    <name>A0AA38MRM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1095808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRM8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="4">
        <location>
            <begin position="73"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3720263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="644" mass="70545" checksum="C661CACF0C112B79" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRX9</accession>
    <name>A0AA38MRX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_674247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRX9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041349483" evidence="1">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="203" mass="21772" checksum="85B498F87068BF7F" modified="2024-01-24" version="1">MFAKINFSSLFALSALAGSAFAAPFNPQTQSLDRRYISFNNWHGLSSLSGFDNFYGSENFSGEISTQVVEQEQEVVCHSLSVEIIQQKLLVLQEMAKQIITEQICDVETQTIVFQQYISVSSHFTADIMHTSGVSAGYDSSIVSHHSSLYNSDGSLSTSDLGFSGSDVGQSVIVPTGTNWNDATSPSSVQAAYAAAQSAISGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSA9</accession>
    <name>A0AA38MSA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic integral membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1089102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3725556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="39676" checksum="384DEDB0B1EF7B91" modified="2024-01-24" version="1">MAVLQSPITFIASIPTVTRYFTLATVTVSLVYAWLQWNSEGAKLFPYLVLVPGSSLFYPWTFVTSALVETTIWELAITIITIPPTLRYLERLWGSLETFKFIVATIFVSNIIAFGFNWIEFIATSDADLFLYGMSYHGQMSLQIGVLVAFTQLIPEHQVQFLGFLKMRVKSLPMTYLTVSTVMTILGFQCPWIIIQFGWFVSWIYLRFYKKNSSDTVGGVESYGDRSETFSLVSWFPPFTHVVLGPGGNLVYKWANKLHLIPSHGGDIENGFNTIPGSARAEAERRRAMALQALDQRLAHTSSPSPQSAAPVSAHTPRPPPAVASPRPEKVVPPADYVAKASFDSESGDLGATEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MT12</accession>
    <name>A0AA38MT12_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1080663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MT12"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3731264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="317" mass="34415" checksum="1C2C56D1A63428A7" modified="2024-01-24" version="1">MLSLFQKSIHQNFIRTMSNSTQTHNAKFTAQNLFDVSNWACVVTGGGTGIGLMIAQAFANNGARVYITSRRKSVLDNAVNTWGKSLAHPRGQLIAIECDITDKKSIQKLVEEVKGREKNIDVLVNNAGVSLGSSEVEKGDESAVQLGEELFGEDLVKWEDVYRTNVIGHFFTTAAFIPLLAATSTVNPGRTAAVINNTSMSGITRTTQHHFKYNVSKGAAIHLTTLLAQELRREGANIRVNSVAPGIFPSEMTAKESDETNKSTIPTGDDYGEEKGIPAGRPGRDEDMAQTVLMLACNQYAYGQTIAIDGGYLLHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTM7</accession>
    <name>A0AA38MTM7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="15">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1075589</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Microsome membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTM7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="17">
        <location>
            <begin position="131"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3732104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="306" mass="33961" checksum="F015CCE770E7BDFD" modified="2024-01-24" version="1">MSETEGQETATSPASSEPQDTTAQEVQESAEGATVEEPQNALTEKFTPKEWDALKAFRNEIPDALASAYPDKSDAKTAAINLWGVTIDPSNLLDARVSVVLMKFLRARNLSVSEGKVMFIATLRWRDEFNVEAACKEEFPQDVFGQLGHIYGKDKAGRPVVYNVYGGNQDLKAIFGDVQRFLRWRVAFMEKSIELLDLESTDQMIQVHDYAGVSMTSRDANSKNAASEASSIFSSHYPELLYKKYFINVPSYMTWIFWLFKPLIPSATLAKMSVVGSGASTIGKALLPEIDAKQLPKRYGGEAEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV02</accession>
    <name>A0AA38MV02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1007311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV02"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041372805" evidence="4">
        <location>
            <begin position="20"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="56"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3715293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="588" mass="67053" checksum="B88256C9B2CFE588" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVB8</accession>
    <name>A0AA38MVB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1215501</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVB8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3714307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="508" mass="56830" checksum="EA96FEFC9E64951C" modified="2024-01-24" version="1">MSVENTAFSASGEEVITRTIDVEVDDTADQLRSSAEFDAFYEIERTAREIEEGDFKRVALQFPDELLHDSVQIFRRLKRMIRPDKELYVLADTSYGSCCVDEVAAQHVDANALVHYGHACMSQTYRLPVIYVFGKKPIDVEDCVSRLVESFSSSESELKSSRSEQIVFRHDVAYTYQAGSIVDRLQVALANFERQLIYTTIPNKLLPPDPEESSRNSSEEGAQDCTIFYVGDESLGFTNLLITHASCNIYQYSPSLKTCHLESGRTNRLLMRRYATMQKGRDADVFGILVGTLGVASYLPLIKHIRTLLAASHKKSYTISVGKLNPAKLANFMEIECFVLVACPENSLIDAKDFYRPIITPYELEVGLQAEQNWTGKYILDFEKLLAEYDHGDRSKVVSSADNDDGDKDEDSPIFSLITGKYRHAKRFGYTAEESNTRSSSSPESALVQRSQDNALSLLRNSAAGQFLQSRTYQGLDPRLGQDAPSALEQGRSGIARGYEESADDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVJ2</accession>
    <name>A0AA38MVJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginase deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_47420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000101">
        <property type="protein sequence ID" value="KAJ3713230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041213498" evidence="5">
        <location>
            <begin position="18"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3713230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="413" mass="45019" checksum="04D307CF79693DD2" modified="2024-01-24" version="1">MLHLWVTLFSLCIYAIAQRHHHSSEQHQEALISVPGDFTFDTNSQIPLSEEPWTSKYGAQNDLGYSGPLSFSHFKYRKCLEDASAPFDIGIIGFPFDTTTSYRPGARFGPYAIRSGSRRQSLGAGRGYTLAWGSSPSDFGSSLLDCGDVPISAYDNAKAIDQMEAAYSTLLSRPVLGGTSEVYKEKTRAFSLDGKEHPRIVTLGGDHTIVLPILRSLHKVYGPVSVIHFDAHLDTWPPRGTTAQEGITHGSFFAVAAEEGLLTNTSIHAGIRCKMLGIEDMQHDDTVGFQVISAEDIDDYGIKKVIEKIRERIRDKPVYLSLDIDVVDPGQAPATGTPEVGGWTTREVKRILRGLSGLNFVGADIVEVAPAYDNAEITGIAAADIVHDFLSMMLVDGPPQPHNGPFSNIDLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVV3</accession>
    <name>A0AA38MVV3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_992414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3734999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="342" mass="37781" checksum="3808E7774A4CD421" modified="2024-01-24" version="1">MNPPAVLQTPGFAHYSLAWSPFFNSRLALASSANFGLVGNGRLHIVSLVPGPGGLPTLKLDKFFESQDGLYDLAWSEAHENHVVTASGDGSIRLWDVTLDNLAIGVWQEHTKEVFSIDWSNIQKDTFVSSSWDGTVKIWKPDRPRSILTLQAHQSCVYQALFSPHQPELISTCSTDGTLKIFDLRSPAYATGPSTNTFTNPLSAAVLTVPASASEVLTLDWNKYRPLVLASGSVDRMVKVWDCRMVKMGDSQVGGTCECSLPGHEYAVRKLQWSPHQADLLATASYDMTCRIWNTIPMGPQPPLRYIHDAHTEFVVGCAWSLYDEGLLATCSWDSRLNVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWG5</accession>
    <name>A0AA38MWG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1159432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWG5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="559" mass="61691" checksum="382311CD84FA5A72" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWS7</accession>
    <name>A0AA38MWS7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="10">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1158099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWS7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="11">
        <location>
            <begin position="16"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3723602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="396" mass="43231" checksum="A95B8DBBADB6CA7E" modified="2024-01-24" version="1">MSTTNSNSQEPLKNVLVTGGAGYIGSHVIYTLLRTHKYKVISIDNYHNSFPAALTRVSELALTELKAASDSQPSTQDIDSTAIDVHECDLNAASAVRSIFSSYSSKGGIWGVIHIAAYKAVGESSEIPLTYYANNVAATISLLQTMQEFGCMRLIYSSSATVYGVPPDIPIKEETRREGDSVYGRTKVMCELIIQDFCDSVMNDSGKLEDFISSYFPPVFQPAGAHPSGYIGEHPRGRPENLLPLLAHMAVGTVTDPVLKVFGNDYPTPDGTCIRDYLHILDLAAGHVVALQALEEGSELNAKVFASSIQSQGRFKAYNLGKGHGMSVMQIVDAMRKATGHDYKTEVIGRRRGDVPELIADPALARAELGFDAPRDLETMCRDLWNWQVKNPTGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXV3</accession>
    <name>A0AA38MXV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1048834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="8">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3737009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="615" mass="70622" checksum="A0D8EE915921D1D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYA1</accession>
    <name>A0AA38MYA1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_962783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYA1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3729197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="220" mass="25615" checksum="F6203B23F8874686" modified="2024-01-24" version="1" fragment="single">IELPVVREKLLKVQSTLRTCELRLGVEGMRDYWRLASSQFFRERMNACALKTRICQRLRARKFECDRIERSFRRQMNSKCMAIYCTVKRRDGGIEVLVRKYNQLCKSMSDMIASQRAPANAQAPKPLVMKELFTLDIDDAVWDDTGLTEKTDVEHLPLWLSNEQVQTGIRGILLQDRADEELKRLKHELSALGDWFNEEFTVIQTALTESHGMIIQFSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYW2</accession>
    <name>A0AA38MYW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome activator pa28 REG alpha/beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_505168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYW2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.180:FF:000002">
        <property type="entry name" value="Proteasome activator complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3728123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="260" mass="29978" checksum="B2786E4610BC18FC" modified="2024-01-24" version="1">MDRDLSVQTEQFRSDIKQAGEEVVFGTFPKKAVLTDLYRELQQLILSTENLDSPFHQATLAKVDTTVYPPPSEYSETDSLSKKRKISEDACSPNETLYPQMAEHDTQHARLSNIVLENKHVKRLHSIIKKECEELVASIDKVRLWVTLAIPKIEDGDNFGVGVQEEILNELHRAQECVYNLRDSPRQHHLARAKICSKLIKYPYVEDYTSALIEHDEKQIFNARHYLLDIRDLYAALTDITQKNIIKIRTPRSNNNSGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZD4</accession>
    <name>A0AA38MZD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_370956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZD4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041316730" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="179" mass="20086" checksum="DE5D02D6053183BF" modified="2024-01-24" version="1">MRFGFASTMFTLATAIYAAPLDVGSSNEGGRLSRLSELESYSTWHNARADADPQVLLVTIRFNDANDEVAPSYRNMNLSIDRNSDPIRFRYNVPNPVQQRASTLIDSFARAKNLGPANVCPMNDFPFSHPDAKFSFTFRMNYVDCLTNFCWAEVRSDGSAVIKVGGRHGRQIYEYTPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZJ2</accession>
    <name>A0AA38MZJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_358476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="372" mass="40075" checksum="68425436ED63DD46" modified="2024-01-24" version="1">MDTKIVRPNVREANSNPPNGNTSNGTHSGSHSPPQSNGTSPNHDSSASNRVDDTVGTSKATIGGSIAGGVIGIALMLGLLWLWKTRKNPNARRIPSQRLRGWVRRLQKGHHVEYTVYAQDLKERPPIDADDGYSDSSQILRTLPTPATHLSLALPLLPPDVYFPVNVPTPLPNYSVPVEGPFSDGGETPTLPPRYWQIHNSSSAASLHRDLSSHKLIGSMATPAPASNNADHGHVFDSSPALPESLPNLPFSTEPTSESPLSPLSLVSLSQTELNSYTSHDFHSRSVLTPTTTSHLAILADNPAGHPQEAESNGQAESPTSSNESELTIRNLRYQVDVLAEENARLSRQNHILTTREGTGRLIEAAAYIGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0D1</accession>
    <name>A0AA38N0D1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1076267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0D1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="205" mass="22816" checksum="D10020CF510FC267" modified="2024-01-24" version="1">MICLSSRRYTTSIFDSIAMIVFLLFAFFPIATLAVAVPRQLIPVSHSYSLIDARSPRIAQARVTFEIGTPIQAQFFKEAQYLISQAKLGNVEIDVKHIQYTNTPMYDEQKVVRFAVRFPGKERSPVWGKISCSGAECNGELVKLDGGVVANRKWVADATYQPLPADPQCSRKPGTKSVTWADAESDKPKGYSKKAEEKHQACVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0J3</accession>
    <name>A0AA38N0J3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1118277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0J3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="94" mass="10686" checksum="E7D72BF3BC9C4E3C" modified="2024-01-24" version="1">METISMDMNGNANTNTRWNGNTNTNTSWNGNGSRTTNRGMYENTAVFFTDYSLLYSFVVRASFPRFGFRYHSLSDTYLCISVAVIIQIAAIWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N148</accession>
    <name>A0AA38N148_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_995167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N148"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="996"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="772"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3733635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1270" mass="139256" checksum="E73F5FDE40A46AE3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1G5</accession>
    <name>A0AA38N1G5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1172499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF119">
        <property type="entry name" value="ROA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1257"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="64"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="693"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3733906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1296" mass="143490" checksum="E7606D6A4CFC3939" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2A1</accession>
    <name>A0AA38N2A1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1061764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2A1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44324" checksum="A57E73C1A23167CD" modified="2024-01-24" version="1">MFCTSVWTQSSRDNRLAIFVFTVTLFAFVVESQLTQYIQTTLNYRHPFLLFWIVHSSFIISLPCHLLYLTFTTPNSISALWRGLFLTITQHLNGLDESSSVDSTRFPVKKFIYLMLTLTAAITMPALLWFAAIEMASVTDVTAIWNTNAFFAYLFSVKVFGLKWEAQKLGAVMLATVGVLAVVYGGSTVSSPSNTVEEAAITFPRSTGPLVGNILTLIASVGYAGYQVYYKKYVSLPSALEFAEDYRPLSASEDPESDTMHASAHLDRSGQFTDSNETVYPPPFGLYSNCWTSAIGACTLAVLWIPLPILHWLGIETFSLPHNPTTAGAIAGVALTGSIFNAGLMITLALWGPIITSVGGLLTIVLVFFSDIILGATETLTIWGIAGSATIVVAFGVLAYDMFQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N392</accession>
    <name>A0AA38N392_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1150302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N392"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041433552" evidence="1">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="170" mass="18670" checksum="B44B9EEC26AB4D1C" modified="2024-01-24" version="1">MRLLNAIFFILGLSLFSKASPLISPPAHVNVTVNNNNKFDCFASGSKRASYIHDYIKDGLVYAGLATDVSQVSISDTPGISAFPPVVFEVESHSPRCIPRKCTGKLDWYFGSRGRSSMTVRDGDGIVIVEIGPGPKENDYLPSWVSRRVHFAGTVDKPEGVSKEPFSFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3C1</accession>
    <name>A0AA38N3C1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1064865</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3C1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001201">
        <property type="entry name" value="ATP-dependent DNA helicase UvrD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="15">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="16">
        <location>
            <begin position="321"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="768"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="861"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3734343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="893" mass="98448" checksum="BEA53F7087A582D4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4D3</accession>
    <name>A0AA38N4D3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1193436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4D3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="78935" checksum="1B4D6C6E49441D9A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4M0</accession>
    <name>A0AA38N4M0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1185316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4M0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041222199" evidence="2">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="316" mass="36438" checksum="844AAEEB2757BF01" modified="2024-01-24" version="1">MIFRDVFLQLVLGACLCIAATTPYNRSEIVTLRRSPSKDRNPESLERNRAPCVVPDQYDKKWYLGLITIRNNVGLHVLDTVTQFSQFVTAKNLTEKLTARDRFSLKGRNNKGIYTLRSEYKVSGADARTYSKETVIVKFIDKADEPQGACEVRALKQFGFFIEAGRVTVEKDEYAVIVKVKQSGAPLRFIDAWINAPVAQKRAVVQDMKKLVHDEIDFGYNNVLAKIVKDETTNDIRLEHIEIVDYGHPGIWPTTLKGFDKEIFTTWFEARWNFLWENLIEDLDNEEKGKEELDNEEKGKEKRMQKRRLSLNQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4Y1</accession>
    <name>A0AA38N4Y1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1220078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="646"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1385"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1669"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1750"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1806"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1883"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1967"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1385"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1395"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1425"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1466"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1669"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1753"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1810"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1825"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1896"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1976"/>
            <end position="1992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2128" mass="229736" checksum="7751E4BA019BB6A2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4Z1</accession>
    <name>A0AA38N4Z1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sec63-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1150210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="280"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="502"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1151"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1615" mass="181145" checksum="9180B19BB0988360" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N510</accession>
    <name>A0AA38N510_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_988893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N510"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="92"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="589" mass="64952" checksum="E45FDA1A5D471CED" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N583</accession>
    <name>A0AA38N583_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_512928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N583"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="23"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="390"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="666" mass="74554" checksum="04A91DCAC0585064" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2H3</accession>
    <name>A0AA38J2H3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">QDE2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1160857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2H3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="325"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="614"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3714311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="975" mass="108109" checksum="0058DB0DFD93E4D9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2Z0</accession>
    <name>A0AA38J2Z0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1213290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2Z0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="112"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3715243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="403" mass="46379" checksum="A263251944D659B7" modified="2024-01-24" version="1">MHDLIELYFTNVDPYFPMLHRPTLERSLLDGVHTTDRRFGALILMICSLASQHSNDPRTLSEGTESEYSKGWKYFRQIQLMHRFEDAPSIHEFQIYPLASLYIHTTNVSSLAFFLVAIGIRSAHQKGVHARHFVVSDNTIETELWRRAFWCLIIFDIYASVTLGRPRVTLPENVDADYPQEFQMGLREKAKDSHTGTVPQSEPSLLSFWTYYIKLFEIVGLANQAFYSVNDSVKTSALWNRLGIPSTEWGQKALIELDAALNKWVDSIPSHLRWDPQRQSEILLRQSSMLYATYYWAQFQVHKPFLSRSSQSEVGPMFPSVTICANSARSLIGLLETHHRQLPFVALPLLIGPLFDSAIVLLINLWRGLRNLVALDPSKELGDVRRCISLLGMYENRYSFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3J9</accession>
    <name>A0AA38J3J9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1159877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3J9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="116" mass="12452" checksum="49E0D66A64EF7A4F" modified="2024-01-24" version="1">MGIRIQQALIHIPLPVVIRMGVSPTPSRATRKHLLLAPPKVAGLLSVLASAQARIQDWPAEGEESVNEQSPNKRDEESIEGEREGGGGEVDRKRPGPIYNSPFTISSSAAEGITSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4C9</accession>
    <name>A0AA38J4C9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1096561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4C9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3719633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="231" mass="26865" checksum="C2F74C5E24197C89" modified="2024-01-24" version="1">MVILSLSASQLLSVVFSILLSMKVMGRPLLTSQLERRRESKLVTRYLSGAVHGLRGKIEYEAHPEDNPNWPWVVEKLEETKRLRNFPQLVDVSLQDRQASSGRILRGPLAVKLDLLDHVVSKLAFQGHFHFISEAVHFMHEQQYIQNLPQDFDSHMESLLVQEKNNWASEYRKVVLDIYTDTHTDKELVRWELHRLLENNCDAYRNQRHPDLPPPTVDFLLSFSRAQCVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5E2</accession>
    <name>A0AA38J5E2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatases II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1042704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5E2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041410937" description="Phosphatases II" evidence="1">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16077" checksum="7B261A0F9270C213" modified="2024-01-24" version="1">MHLEQICKSSFWLAILLRPVGCMVEHSARKGCVKSYTLHATGGRRRSFYKSDICLTITIEYIHVVQILSPNLNSPDNAYVLVIHCQRGGKRAGLFGDILEKSYPPQISAPRQLHHQAITYGHHYEKITLGSSSTQATQINCPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J670</accession>
    <name>A0AA38J670_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Delta-12 fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1087726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J670"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fatty acid desaturase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="421" mass="48309" checksum="156F781803C962CA" modified="2024-01-24" version="1">MLSLFKDSPEYEARKARPFSPTKVTISEVHAVVPKHLFQKSFFTASLYIARDVLSAVALYKLGWQIEPLAASLVTDYGAPAYVGTIAKWVGWSVYWVSQSVVLAGWWCMAHEAGHGNVSNKKWLNNLTGFLLHSFVLAPYFAWRSTHHSHHKATVSIERDENYVPRTRSDFKLPSESVARAVDYHELFEETPIYTAARMLLMQLLGWQIYLCLDTMGSPRHPKGTNHFNPSSSLFKPHERNGIIASNIGLTVMSCFLYMWTQTVGVSAFLKLYFVPYILLNHWIVMLTYLHHSDPTIPMYRNRQWSYLRGALSTVDRPLLGWAGRVYFHNVSHDHIAHHLFSNIAWYNQPYVTEELKKLLGEEYNSDSTNTFRALYRTFTQCCFVEDEGDIVFYKNQDGKAARELAPDALDRPTVVAKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6W7</accession>
    <name>A0AA38J6W7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_491763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6W7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="67815" checksum="D2DE8D5C4F834FDF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6W8</accession>
    <name>A0AA38J6W8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_221826</name>
        <name evidence="2" type="ORF">DFJ43DRAFT_221946</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000170">
        <property type="protein sequence ID" value="KAJ3709553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000170">
        <property type="protein sequence ID" value="KAJ3709557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6W8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00034">
        <property type="entry name" value="Antisense to 5.8S rRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3709553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="53" mass="5831" checksum="05C146AA8744AC49" modified="2024-01-24" version="1">MPSGIPEGARCVQRFDDSLNSAIHITYRISLRSSSMGEPRDPLLKVVLSLMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J715</accession>
    <name>A0AA38J715_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1009261</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000139">
        <property type="protein sequence ID" value="KAJ3710357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J715"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3710357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="662" mass="74119" checksum="A144CE34663501C6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7K6</accession>
    <name>A0AA38J7K6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_854611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000087">
        <property type="protein sequence ID" value="KAJ3714949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7K6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="204"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3714949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="377" mass="40273" checksum="C4A7745AFC23CE61" modified="2024-01-24" version="1">MANYMPLPETHRVLQLTSIAEPLQLKTAPTPQSGPGSVVVKVLAASVLSYSGDIYNGQRQYPFPQPLVPGASAIGRIVTVGPDATTLVPSQLVFLDCTIRGRDNPTGAMILSGIIEGFTEASRKLMHGEWRDSTYAEYTKFPLENCIPLDEQRLLGPVDAGGLGYCVEDLLHISRLLVPYGGLDDVGLKPGETIVIAPATGPFGSAAVRVALAMGAGRVIAMGRSETALKRLCALDNRIVTVQITGNEQSETEALKRHGPIDVFFDISPPMAVDSTHLKSVIAVLKHGGRISLMGGVRGDLSFPYAAFMQRNLSMKGTFMFSREQILSFVKLIQSGLLPLGEKGGLSVGGKFGLEKWEEAFEKARVAGTGEVVAIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7P7</accession>
    <name>A0AA38J7P7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1002546</name>
        <name evidence="3" type="ORF">DFJ43DRAFT_1002562</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7P7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="402" mass="46622" checksum="989933B369F9C9A5" modified="2024-01-24" version="1" fragment="single">ICESGRTQEFLQLQWEAQVKAQTKPMPRNCDASRACVAQLDAILTDTNAPLYEVAEAELELERLRPKFKKALAEVSQQERLLGVEGMAQYRHLVSSPFLQARMNALAVKTRLCEKLRARKFEFDRIERSFRRQQFNKRKIVTHTEDSIKRRDPGIQRLARSYNELHKKMVDLVRTKRAPRNAVIPSEIDMKHLFKLDVDDNIWQDIGLDEMTDLEELPLWLCNEGVCKGIQAKLELDWCNEELCRLTHERKTLQEWMAEEWDVLCTTIKDLDGGSGKPYNEDLLYQLTESKQNLLRLCVRWDSALELLPVIRGLNTWGPTTEELEEEAKKMHVEVLVNMVISDEDKETGDEAEMQEYETNESDVDDEFDEDDLDVGLVERLDALRLADSRTSDCDSDGEMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7S0</accession>
    <name>A0AA38J7S0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_979533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000120">
        <property type="protein sequence ID" value="KAJ3711435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7S0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="58" mass="6676" checksum="3BFFBFE6B43F70A0" modified="2024-01-24" version="1" fragment="single">MPISNGKKYFVHGRCHVTSWMEGRALRKETGKAIGNWIYEEILCRWGCLAIIYTDNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J856</accession>
    <name>A0AA38J856_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_542496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J856"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3727300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="96" mass="11007" checksum="F5F071E9A0D16E2C" modified="2024-01-24" version="1">MSNQPSRRAILSLYHSTLRTSKSFSSYNFRNYFIRRSKDTFRVIQSESDPARVKSLYAEATRELAALRRSAIVNQLYGGSRLAVEGQKPEMTRADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8E3</accession>
    <name>A0AA38J8E3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1043167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8E3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3717318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="312" mass="34117" checksum="620F6213A11FDF8C" modified="2024-01-24" version="1">MLLPHSNRPLSQSTATGVQSPVSLLLLSPSQPSACSTSLSPISGFPHLKSFGPPTIISRTNIEAPLPQLDLCLHQSTADGVCGNPLIATENSPSPLLLLFPRQTPSSPSLSPLPGFLSLKSLSPPTIIDNVLGASTNSRRQEHSPPPPPLLLFPFQSSVSSSSLSPISEMPTLKSFSPPTTPDVVSPITEEIEFPDNLQTVNSKPQEDVYFIHCKDKNRKIKYQMLESKDPVNPLSPSPVPDILSCWQTDGDVSFHEYGCPVQELCHSHIQWRINEAPKPTRPLQQELKEVEELEQMVERSEISAFLKNADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8N7</accession>
    <name>A0AA38J8N7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kama family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1008671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000113">
        <property type="protein sequence ID" value="KAJ3711892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8N7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00238">
        <property type="entry name" value="KamA family radical SAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538:SF0">
        <property type="entry name" value="L-LYSINE 2,3-AMINOMUTASE AQ_1632-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="LYSINE 2,3-AMINOMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3711892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53952" checksum="0AE072449A5250B5" modified="2024-01-24" version="1">MHGGHRLSSQYLGFRTLTPSRLPSKISQNSRRPAWYRTYSTTHSLFCETSRVNFREPYWYKIPVWKDVTEKEFLDYSWQVANTVQGKYKLAKYLYAVLPEHIPYDEDAPETSRHIQTRDMFVQDVLGGISLAPMSIRITPHVMSVIDWTKPLSDPIRRQFIPLRSSFIEDHPMLQLDSLNETGSSPTPGLVHRYHDKALFLAVSVCPVYCRFCTRSYSVGGPTEEVSKKNIFPPTRRRWEPMFKYIEETPQLSDIVVSGGDGYYIPPEHLTSITERLLAIPHIRRIRIASKGLAVCPSRILTPGDEWTQAIIKASAAARQMGKSVALHTHFNHPAEMTWITRLATQKLYEEGVTVRNQTVMLRGVNDNVTTMKTLIRMLADNNIIPYYVYQGDMVSGVEELRTPLSTILEIERHIRGSIAGFATPNFVIDLPGGGGKRLAVSYDTYDRSTGVSTYVVPDMNGGKDKVYEHHDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9M8</accession>
    <name>A0AA38J9M8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ctg1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_711296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9M8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18018" checksum="20613317185754EA" modified="2024-01-24" version="1">MTTALASNSRFMLKAAARAPIFRSAGRAASRYGNTTMSLRFSSTMHDNDPNVLDTEKKRNLSKTQHGTSTPHKHAPGWNEHLASASEAHVKADRSTGSPSELADQTIKYIHERHSPENAVQPTEASFSRDEVGGPLGQAQGSDREVIEEEIVEKKSTKKMSVSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9U7</accession>
    <name>A0AA38J9U7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_807882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9U7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041438806" evidence="1">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="204" mass="21526" checksum="04354949FC838AD5" modified="2024-01-24" version="1">MFAKITLPFLALSTLAGSALAAPFNPKTQSLARRYPSFDNWGGISSFSGFDNFYGVDNFSGVVSDQVVVEQQEVVCQAVSIEVVQQKLLVLQEMAKQIITEQVCDVETQTVVFQQFLSSCSHFSSDLLRTSGVQVGYDSDIVSHYGSFYNADGSLSTSDLGFSGSDVGKSVVVPSGSNWNSATSPASVGNAFNAALSAANGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA06</accession>
    <name>A0AA38JA06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1120965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="291"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="637" mass="69776" checksum="A3813AD161FA9F24" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA57</accession>
    <name>A0AA38JA57_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_996731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA57"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="241" mass="27926" checksum="299C46418C6492D0" modified="2024-01-24" version="1">MALLLVYTDKGAEISETEFNEWYDEEHIPRLLLFPGCTRASRYQAIDSKPPPWTALYHLDSPEIPESREWYQLNEQASDNEKTILGSIPIITRSIYTMFHGSHAKDIPHHSAGKVACIVHLQIKSRDFDVLLDSSREQADLEAKFKLWHRNFITRGVSTTPGWVRSTMYTRYSGSDMRTTPELKIAMDCQLLVIHEWDENGDAMEISKLEANVAAQVQIWEKENLCDVTRETRIFSLHKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB83</accession>
    <name>A0AA38JB83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1006567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB83"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3716814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="74" mass="8678" checksum="928A47E6E5FBD6A6" modified="2024-01-24" version="1" fragment="single">QIIPVRCFSCGKVIGDKWNAYLEFLAKDMSEGDALDALQLKRYCCRRMVLTHVDLIEKLLHYNPMERTKDKAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBA4</accession>
    <name>A0AA38JBA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1070284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBA4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36558" checksum="44C6FD17C95FD98C" modified="2024-01-24" version="1">MSVGTRSLRRLRMASLPTRSFHLATILEDLEQCDFPALNLGTESFPSTPRETLIFEPAMSSLVPSSRTRSWSTLSAEGRRLKQSNTSKADVDRECMICFHLPQRPSRTKCCGKLFCEAHLNDWLAGSSNRCPSCSAYCHPKTDVLSLASPPSPTALSPQSSPGFFRHREHLNGDKLTGRRTGQSSRSRCHSPSPSSSSSSSIDPNTDHDDEDKSVQAKTVDSSFLQSFFVKLIRHFLDDSSLGVPEVSPVDNLQIELKVKSSSHVESPNSELPPSFSGYSSSQLQELQTYSVSSPSNSEVSSDPEMTTVALVGKVIGKVLSIVALMLVFWILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBE6</accession>
    <name>A0AA38JBE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1159044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3720246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="295" mass="32397" checksum="103C768A39F2476C" modified="2024-01-24" version="1">MATCIIDMYPTNRMFSWKLFATELSKVAQDDNGPELMLGLQKISQEAKDRKRLVTYMNYGVSQARWDIAYQAQTRTGQYFGIPGNKSEEDIIKAVNWLLQGQRYSHEEVDIQAKTSNELPFLSPLFALQKVPIPLIAMVGALIAHSLGEYATGSKTKSDIPLTGKNIGPIYRNLMETIKLLEKDTPKYVSLVQTRLYDEMMSTGQATLPVQVYSASKFNAYALAQKKSKDSKNNAPQDSEAAAAQGSRDMAEVLCNDGENPKLSKASTSCHGSTDSGADGSQEKAVESTQEGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBV3</accession>
    <name>A0AA38JBV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1137603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041280513" evidence="1">
        <location>
            <begin position="28"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="204" mass="23395" checksum="9A9AB1B7C4BA3755" modified="2024-01-24" version="1">MFLLKPSSLRQLLLALAIALFSLMVVASPVGTTPPPEGAPPTDKFDIQYGRKQTGSEEWLPNTVNFAKDQEIILFIGKHLLRFQALPKPHIIHEEQITLPDMDHLIQLGPKRRTQLSITIRPDEAKDFWALMVDLPELKKKVGWTIKDDLSYHRAVRDVLTIDPKWGRITIQWLLDLVNIDMIQTNLRNNRPMNPTLLRATPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCY0</accession>
    <name>A0AA38JCY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_134848</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCY0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3734572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="507" mass="57156" checksum="C4E438158C8C3093" modified="2024-01-24" version="1">MPSATVDILFALFACFYLYKLLFTRKYPLPPGPKGWPLIGNAFDMPKTHAWRTFAEWGKKWGPILSIQVLGTPFIIISDPEIADDLLGKTGSLYADRPTVQMALLTGWDRALSGARYNARFREYRKLIGKVIGTKGSMTKFYPVEDYQANMSLKRIFQKPENPASAIRKTAGAMVLHLTYGYKILEDQPDPFIAKAELAMEQFSDTHRTGAYIVEIFPILKYLPTWFPFAEFKRKAVECIGPCNEMADVPFAYVKEQLDKGEENNSFAADLLKDKSNSSEKLVDLKWSVASFYGAGSDTTVAVVYSYLLAAILNPEIQRKAQAEVDSVVGKDRLPSFQDRDSLPYIEALVKELYRWLPIVPLAVPHRAMKDNLFRGYYIPKNSLVFVNVWYFLHDPTVYKDPSTFNPDRFLGSNPEPSPIDRGLFGYGRRVCPGAHLADVSVWINIVKVVAGIEVSPAVDEKGQVKMPVPETTDGIIVRPIPFECVVKPRSEYLLHVLEEALKDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDX2</accession>
    <name>A0AA38JDX2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_580088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDX2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="70474" checksum="5C6A16A107E41950" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEE8</accession>
    <name>A0AA38JEE8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_561780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEE8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="309" mass="34548" checksum="35F757CEB519889E" modified="2024-01-24" version="1">MQGMATREEQEPYYVVFDILQFTALALISATYLSALFSQKLQRMKTWFALMISCLLYCISFVLLVGHQTGPSPSLDLCLFQAGLIYAAPPSVAAAGLAFVVELYLRLTTTLTQRRLDNRIITGLLFMPPVVHQIIFWIAMFTGLPKPDIVHRNQQQMFCDIGDDIPTTVTGITVIVLIAMMILLELYTIYYLWSVRSVFRDLRKRCECGPIFPFALFVRVGIFTFAGGLGMILVDILLNKRSALSGGAGTIDLMAVIPLTIALVFGTQEDIVQIYKFWKKKGPLEDTSPADIDIEVRGKIDDVDRSSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFL0</accession>
    <name>A0AA38JFL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_174925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFL0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38277" checksum="90A4EA0D3710A9B8" modified="2024-01-24" version="1">MSVPATETHATLSRTFPPPSLAGVPFEYILDQLRNLAPSYWGNSESSDCTLVIPVPYPRVRSTSSSPSITPFRPSYDPSGLGRRATEPSTLAILPRITLKLHSEYLSAHSNFLRSLFSGASPLGLITDGPSTHPTPNTPFRTPSGRFTIPADRLPRLLNSSPTHPVLFVPVPDPSSIDLVFHWMYFGDFRHIRDSLHEGYIQWEGIARNVEYLGLSDEIKVFLGDWYARWLHSDRRRSCENLTSPHSISDSESDSDSLSDDGELFNLNGEFSSDETLVLDMDDDMDCLNIKVVDANREQPTRGRDRATRGLSWTSGYENKFPDASSNPSNARREGSPIPPHCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFT8</accession>
    <name>A0AA38JFT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_358537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFT8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3731734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="204" mass="23165" checksum="135CE0ADF124464A" modified="2024-01-24" version="1">MLCGSSKHTSFGRRALQRKVVVCGDGACGKTSLLNVFTRGFFTQVYEPTVFENYVHDIYVDDQLVELSLWDTAGQEEFDRLRSLSYAETHVVMICFSVDNPISLENVETKWLDEILEFCPGVKLVLVALKCDLRDDYSIKERLQRFGSHPVQYEEGLAVARRIRASRYLECSSKHNRGVSEVFYEAARVSLSSRNRGSSGCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFU4</accession>
    <name>A0AA38JFU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1000054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="68" mass="7485" checksum="85B396FDA14FA645" modified="2024-01-24" version="1">MDPALHAPLNLRPLSVRPISAKNVAKQLGNFVEDFQARTTAAQGGNTAVTVQLQKLKDAMQEELERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG42</accession>
    <name>A0AA38JG42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_349306</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG42"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3731959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="445" mass="49833" checksum="56B57F1CECC70A04" modified="2024-01-24" version="1">MSDQELTILTLNCWGLKFVSKNRRERVVAIADELSHTEEYDIITLQELWVYTDFEYVRESVAKYLPYAKFFYSGALGAGLAIFSRFPIVATEIQPYSLNGAPIDVAGGDWFVGKAAASVIIVHPILKEVQVFNTHLYAKGGEDGPEHNRAHRLVNAWEFAKLARRAAELGRYVIAAGDFNSIPTTLPMTVIREHADLKDSWLVTHPFSNTPSDVTPSPQEAIDDFGVTADSPINSYSAGKGLDATARRFCGKRLDYIFYRQPHSYNPAELPVLHCKESRVMFTHEVPGTPFSYSDHFGLKSVLQIQTPGALPSSSDAVFPSESQTAAWSTQSSEPSEISQACITKMTQALSSCYRFSKSRAQKELALFVLCLMLLITIAVASTWFPYPWLNPIFIVFAVFLTWLGTTMLYEGYVYGQWECNALMNVVEELEVYAQGLELQSSRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG72</accession>
    <name>A0AA38JG72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG72"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="123" mass="14463" checksum="2550F61C9E3E381C" modified="2024-01-24" version="1">MIKSYKPTQLVSSEAESKNSEICTDDDDPDDRTWEHVEAQEQHVEKHVEAQEKHVEAQEKHVEAQEQHVEAQESHMVSQDQGSGNHVHSFSTRIEKQKDQKSDSLYNKERLYYNSERKKRKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG83</accession>
    <name>A0AA38JG83_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1062357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG83"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="11">
        <location>
            <begin position="36"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3734394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="169" mass="18058" checksum="75043B46441FDDAB" modified="2024-01-24" version="1">MSSADALQVKKRRMSTEPEMPIAPISQLLIKRHSETAKIPSRGSALSAGYDLYSAEKKTVPAHGKALVDTQISLAVPAGHYGRVAPRSGLASKFMIDTGAGVIDADYRGIVFVLLFNLSDNDFEVEKGDRIAQLIIEKIHTPEILEVQDLDETLRGAGGFGSTGGHGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGZ0</accession>
    <name>A0AA38JGZ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTLH/CRA C-terminal to lish motif domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_523053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGZ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="161"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="409" mass="46781" checksum="10BA38DABB87FEF1" modified="2024-01-24" version="1">MTSKVDVEGAFLFEQPFARVPYENYRKVFRSSQKHLEREYGAIQSAAEDVSTSVKTGTVKRDEIASAINEMISRMEMLKRKLSDLHDSAGKPTQDVIRERLQHMATLENFNSTTQVEYTEWADQRLDRWLVDWCLRHGKEKTARRIAREKDIEVLVDLDLFSDIRRIEGALSEHSCTEALAWCSENKASLRKVKNTLEFELRLQEYIELCRSNKKLEAISYLRKHFISWWDTHLVHIQQASGLLAFSSETTCRPYMRLYDPLRWNTLIESFRRSIYTLNTLPSEPLLNLALYAGLASLKLPACYEHSTKNVDCPVCDGETGSGFAVQGMGLGKLAEEVPSSYHANSTIVCYITKKIMDADNMPMAFPSNGYVYSREAMEEMAARNNGIVTCPRTGVSCSFTELRKVFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHK9</accession>
    <name>A0AA38JHK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1143244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHK9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="390" mass="42873" checksum="55767A2720C54ED2" modified="2024-01-24" version="1">MVLATELPQISISLAPPEDPIVEPISPFSWVKATVNDDGFRSTHLTPPPTHLKFSTNLPSPLGPAESKAKGLERDHFEALLRATRERNAYTGGKKDGDLRKEIALKAHKNKQVERRALFLSKVLAPPSPTAVSQPVTPPDSPSVFHFRFPSPGLVSPLALFESLNEDSPTGPLSYPIDPWVEQVDYRLPHQKSPSKVKEPKYTNHKKLPSLEQITARLGPNHVLISSSESNGRTTRLPNFLTQRQASAPADERPRLSLSVGRLQLPIKAPQPTKVESAAVLLPPKSPSSPLTPQLQVTTIVVPRSSSLSPTELSESNLNALQSRDRKAKDMLSTLRRRVTPSDDGAVQGRGSVQHLCLDRRWKRHSAPADITPRPRVGFEHPVLSMKGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIE5</accession>
    <name>A0AA38JIE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_996743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIE5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="625"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="861" mass="96743" checksum="891DA938AA1C22C1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIQ8</accession>
    <name>A0AA38JIQ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ASST-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1157308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIQ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041423876" evidence="2">
        <location>
            <begin position="29"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="549" mass="59830" checksum="F819709B4AFD05FD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIZ1</accession>
    <name>A0AA38JIZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TAFII55 protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1070990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIZ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="131"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3733077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="500" mass="55484" checksum="1065DAC66E16012E" modified="2024-01-24" version="1">MYDDLIIIDDEEPQAGPSYINGSSDADPPTTLIASTSNPSALSGSRTSSRLRASSHAQQHAPRESSFASPAPKNESKNSNISTRSGAQRPKTQPKLKLKLSEKLAAQAPGMSFLGQYDRELDSDDNEDLAFEEQFILRLPPGEDCDRLRKSVAAREVPGDVWFKFKDSRRGVFHIGNNTYASKLVDMPCIIESQKTLDNKQMFKVADICQMLVVEDRIDNEDVVTREKSLNIDDFIWPHGITPPLAHVRKRRFRKRINKRTIETVEQEVERLLEQDNLAKEIKYDILENVNPDLSDSEFIEREEPIDAPTPAISDTGDPATPGGILGDEGEDEDEGDDEPDGDIDEELAAELDLALGDEDDDGDDDDDDDDSDDDDDDDDDDDEVSQARKLLNEEIRDLQAAVAKKGSEIASSANPLIRKRFEDALKKLTSDLEMKLAQRDEMQEKQRMEDEGIVVDNIRGGGDSDSEVEVDGVGSAQLRGDEDLFGGEDAVMDLNQIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ35</accession>
    <name>A0AA38JJ35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clasp N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1131097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ35"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF60">
        <property type="entry name" value="CLASP N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="196" mass="21834" checksum="AE6FA24DF2062FC0" modified="2024-01-24" version="1">MQAITCNSHDVQLHNNSDIISIARELHRPINSAMKSERTRLSGPATDLIATMASELGTDFEPLLHLFFPTLLLLCARTSKVVVGRARSCIMSIIETTQLVVVMSYLIQSIRDKSVSLRTVAAEGTLACLNSLNPPDLAKEERTKEIEGLIRMSIRDANAEVRKIGKQIYQAYELLLPIRAESTFDANKQEISRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJF5</accession>
    <name>A0AA38JJF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glycosyltransferase family 24 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1085879</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041280692" description="Glycosyltransferase family 24 protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="34"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="296"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="424"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="706"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1188"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1454"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1469"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3728096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1486" mass="166974" checksum="588CAA9C0953B4DB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJW1</accession>
    <name>A0AA38JJW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribophorin II</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_518649</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SWP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJW1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041467144" description="Ribophorin II" evidence="13">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II third" evidence="14">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="15">
        <location>
            <begin position="172"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3736689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="275" mass="29809" checksum="43BDD5AE4C4EFE82" modified="2024-01-24" version="1">MKAAFLLFLATAAHAAKLSADSVKYSIISAKGEPSTKSFVPTEKPSSEVVTLSEDQTLKLSLQVVDQATGKGVQPEQAFLRFYDEQSGEEGIQPIRVTSSGKAKFDLSMAKPPASLPPTSTAPLKVTLLLGSSSHSPQKLELFNLHVPASHPAPVHPDEVKFHLLPELAHTFRPDPKLPPRAVSAFFTGIILVVPWSILLGLWFSVSPQVPRLFSPNILPFTASLGAFEFLLYRYWVDLKLGDVLTYGAVLGVVTVFTGRHALASIADRRLGSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKQ2</accession>
    <name>A0AA38JKQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1163942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKQ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3737756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="993" mass="110403" checksum="F4DC88715B3CD586" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL04</accession>
    <name>A0AA38JL04_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_134232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL04"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="215"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="408" mass="45475" checksum="B6E09B8BE9F1086D" modified="2024-01-24" version="1">MYKSVQICSFSVCWSPIFFIFFEFSSFHIFVIFLDPIPHQVMPPLPDFNSPKLLGALEIGAFISIFMFGIVTMQGYIYYQNCKALGDSRRFTFFVALILLLELGHTIATAHTVWWATITIADMAIKPGNGYLIVACTLYSAIITFLVKIYYIKRIRILSSKLWLAIVGWLLSGIDLCASLMVSYVALRDVPHEPNNFDVQREWGWLITSSFSLGALVDVFITAALVYHLYVPLPAFPMKSGSSAKLVKELLIWTIETGLITSLASVACVVCFHTMEYNCLLSKSDHRSKTDKHLSLVIWFAVYLPLAKLYSNSLLASLNARPARRQRQHQDCGSSNISQTSLGSTNSPASVSWASGVSKIMRRSTIGSVSITRVNPLSPAISGLRRLTVGSPLNANIRKVRFLSDICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL50</accession>
    <name>A0AA38JL50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1078691</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL50"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041259443" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="333"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="437" mass="47982" checksum="D74E9C20335CAE9F" modified="2024-01-24" version="1">MLRPTGVFVLGAAVLFTASLSSTLINALDNGVGKLPALGYNTWNAYGCNINEDLVLESAQLMVSLGLQAAGYEYVNIDDCYAEKNRSASGDIVADSVRFAQGMKNLTDQIHALGFKTGIYSDSGWFTCGGYPGSFQNELRDATTFQDWGFDYLKFDNCAIPFDDIIREGMIGKYTRMADALAQLSKSSGQPPFLFSLCQWGWEQVWLWGSTLGHSWRVTGDIAPDWDSLAYIINFNSFITQATSFYGHNDMDMLQLGNGGLTFDEAKSHFTAWALMKSPLLIGTNLSAITPDILQILTNTEILSINQDPVVGNSISPFRWGINPDWTSNSTFPAQYYSGPSENGTVFMLLNTLNETSDMFFNLTESPWIRAGRQYSVRDLWAHTDNGTAVRNFTAANVPPHGVVALLLEDAGDEPAGIFPPCAVWFNCAYENGTAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL98</accession>
    <name>A0AA38JL98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1077820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL98"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="10">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3731571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="335" mass="37066" checksum="853C9E6C6CF9FAD1" modified="2024-01-24" version="1">MTTKPPKTKNTGPAAKGTRTSLSHPGRAFRGKGKKDADALPSADRIKRLYTSLVAQIDGGHWKGAEKTCDKILRIDPADADARQTKLFIYLQKDEYRKALELIDEDMPENTDLKLKLFEKVYALYRLKREAEAEVILEEIKNKEVTEMNEEEERGVLHLEAQLKYRQGKYQAAYDLYQQLLDTADPSSEEYHDIQTNLLAAQTYLDFMNSGYLQAIDEAANDAGLKDIEDLPPPTIPSNIVTLSATPSTSVPAKEKKKVRVKRVPKDVVPGVTPPPDPERWIKKSQRSNRPVHGKKSKGRTTGATQGFTTEMSTPSVAGGASGGTGSGGKGRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM03</accession>
    <name>A0AA38JM03_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Anaphase-promoting complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1071211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="60"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="9">
        <location>
            <begin position="1584"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1714"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3732785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1950" mass="217868" checksum="F3BC2774E13EC935" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM07</accession>
    <name>A0AA38JM07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_992148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF44">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09754)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="18419" checksum="187289FDA89F9280" modified="2024-01-24" version="1">MPVKLKGSCHCGAVRFTLESSTAVPYQLCFCSICRKVGGEGGSINLGGHSNTLNILQGKEYISVYNAVLNRDTPNEKIASSERNFCSKCSSMLWLYDEHWPELIHPFASAIDSPELEPPVTMVCIKLDSKPEYVRLPEGKKEIYDGYGKYSLEDWHKEHNLFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM96</accession>
    <name>A0AA38JM96_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_991697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM96"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="1">
        <location>
            <begin position="11"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="216" mass="24868" checksum="E221A499C09CD43B" modified="2024-01-24" version="1">MLCIGPYSAWVVVDGVGLETHCAEASHSICTASTSGWISSEAGKKFSVYWHNADRDITLEAVVSIDGVECNRHVMLAAKDFPDRPDTVRVSYTRTSESTRRDFIFSVIELTDDDEWLPLVDYTKFGVITLELWRLRVNRVVRQQLQHDCYKPLILQPQVLHEQTKRSGIHHVRFGEEYNVSRPTVDMVDGQKMDRVPYASFLFRYRPRGLLNLYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMA4</accession>
    <name>A0AA38JMA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAPP trafficking subunit Trs65-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1061943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="1288"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1350" mass="141704" checksum="EFACEDD4B4060771" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN16</accession>
    <name>A0AA38JN16_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_492961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN16"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3729010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="93303" checksum="3054035B317402D1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN29</accession>
    <name>A0AA38JN29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_177969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN29"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="178"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="373" mass="40966" checksum="E547DA6CF0B52F57" modified="2024-01-24" version="1">MNFSSGNESDSLTGLSEISPDDTVGAAFVGYSFACVVLGVLTSQVSNYYQKYVADPKPVRILVGIVWTLELLHVILISHALYHYTISLFGSVLAIITEHVIWSLVTQVLIAAISGIIAKICFVLRIWKFSRRNIFITATISMIIVAQFGLIIGSYKLQSLFYLSKLRIIGSAALATGALGDVLTAVASSFYLRRLRTGFTESDCLVNHLTRYAINTGALTSTMSLLTLILYDARPNTFQFMGVYFVLSKTFAVSLMCTLNARKEIAGRALEEEEISHDSGSAIIPVTSNDTSTVSTAFRMESDYIRSGNHIQPYLIRENIASPSKMDVKLSVSTRNRRTSSSASSASWQVRNTDSQMTWTASEGINPSKLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN93</accession>
    <name>A0AA38JN93_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1058909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN93"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="553" mass="59990" checksum="8B6EAF985EB77651" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNB7</accession>
    <name>A0AA38JNB7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1037220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNB7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="280"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="540" mass="59452" checksum="8E591C211FB18D85" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP03</accession>
    <name>A0AA38JP03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_990573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP03"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="231" mass="26856" checksum="95406250AA6B8694" modified="2024-01-24" version="1">MSNRLASFKGPSTPSSSPVQQRQASITPSSPARVTESTYHRSLRTLLQEIRSTTETWDDLVLIDGLKAIKSLVDLRTELDNAITRAPNRLPRRYLVGPQLEVMDQRISELDAVLAKLQKQFRKLNNLVENLETLVFEAHKNKGWRWVENEPLWTTWSLEKFASSIPEILIHYHRSLNEHIMLANILRSHSVSFDESREAISKWAEQPWLEENGWDAKWEDLCSVEIDRWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP46</accession>
    <name>A0AA38JP46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_173482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP46"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041403913" evidence="1">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="420" mass="45884" checksum="8AD53D9A6EC8B371" modified="2024-01-24" version="1">MKLVNFGLLVLPLALSIAGAPLPMTRDSEVVPADEDVADCHSLNNHPQYGIFYTGPGCPSSRPCQLTSAHWDNDLNPFNVWDSVTMDHNSDGESMGYDSVPSTELAIRLGSDLVLVSRDATKLQKTGKTLTKTGSALGKAAKGVDAVPEIGEIVGTAIQVVATFLKLLGHIFSGIAEAERKSAHARGEFTQKVTDQTVKEHPGWLVVTVHPKHTIFFQGNEHTDWSHSTTSIKTVCHFLGSVRGHHLNFTTQVTGTYKFDVYAARAGIFSNDGDGGYQNWAWSAPSQHIKLAGYENRRLVFTGGTPQNHPTSGKCMVHAYQYQKNHKKVNELDHYTIVAVMKDAKGVIVGFEGNGDGSKPLPVSSQLHDSLTIITGPNDKAPLSFSFDKDKWDSNSKSRCTVGKFEHGVRQMDCNFQCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPP0</accession>
    <name>A0AA38JPP0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1061346</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPP0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3734728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="526" mass="58258" checksum="EB67C9A33D502FB0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQE5</accession>
    <name>A0AA38JQE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1130857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQE5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="468"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="886" mass="98107" checksum="B434563810E1098C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQS1</accession>
    <name>A0AA38JQS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1064685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQS1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3734320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="40305" checksum="30B3BECACB30CE63" modified="2024-01-24" version="1">MSGEELNPYELLNVKVESTDQEIRTAYRQRSLKVHPDRNPNNPDAARKFHELNQAYELLLDPLRRLALDAKLRLKQAQKERYKNYDLKRKTMVDELEERERALKKTKSDKQKEEAARSQETERIKDQGRRLREEKLKEFEKKEQEAMSAAKEEQETDAPALQSTDTTVRVKYSLSEHPSLTTASSLASLFAPFGVTDVDTIVVSLKSPKKAPHKPPKYGTALVPFKRIGDAFAAVCATGLPERGLSGIEVGWIGGSEPEILGWLRKKGHLGPLGSGLSNEPQVQQPEEKALPPQAQSRASGSDVFSSFPSTFPDFSTPDEAPKVKDFDYESLTLMRMRQAERARLEREILEKEGTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQT7</accession>
    <name>A0AA38JQT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="9" type="ORF">DFJ43DRAFT_1130638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQT7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="203" mass="23299" checksum="C5B3DCC07B42A623" modified="2024-01-24" version="1">MTSQGNAYEVALFGEFFARDLKAILNRITLHSEYSELMHTCEVTFEPIDAQHQRDTGNEPVVLRAKKELTRKDEGWILYSYLKPESVRAHPEATVRPWATCHVVGDALSFAQALGHTRRSQIYKRGYLFRRGTLVIQMFQQEQVDPSTQEHIPAHPDTLWEVEVKTATPIRNTQETPLSQSIDAVLEVQLLMKGLLDLRRQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRK3</accession>
    <name>A0AA38JRK3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="6">EF-Ts</shortName>
            <shortName evidence="6">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSF1</name>
        <name evidence="8" type="ORF">DFJ43DRAFT_355631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3732008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRK3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000001">
        <property type="entry name" value="Elongation factor Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="7">
        <location>
            <begin position="111"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="320" mass="35469" checksum="BE3B919A39D00A95" modified="2024-01-24" version="1">MLRFTQAVRCGRPLTRNRLYSSIPNKSRVQLVAELRKLSNAPIIKARQALDENNGDFDAAVQWLEEDMRKSGAAKAEKVKDRATSEGLISISVLEGGVGSRIRSGSGRVKASIIELNCESDFVSRTEEFARLANDISEIVAHSQTHQENTSSPFTTLSVEDLLHLSHKSGTVGSLITDLIARIGENISLRRAMLLTSPTSSNTAYRVASYLHQGRVGALDLISLRPSQSSLFNDDSFIGDLEKLERALAKQTAGFMTLGISEKRNSEDEQETVLYEQPFMMLGGENASIPVRKVLDQWQEKWGLEELAVSNFARWEVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSZ8</accession>
    <name>A0AA38JSZ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1049760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSZ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041372044" description="mannan endo-1,4-beta-mannosidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="12">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3736603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="449" mass="47389" checksum="6D27FF0BE3AB43C1" modified="2024-01-24" version="1">MARVYGLLALLPFIAKLVTAQSVPEYGQCGGIGFTGATTCAAGNICVVVNPYYSQCLAGTSTGSSVSSTSVTSTTASGTTTTTTSSSPTATVSGFVKTSGTHFTLNDKPFTVVGANSYWVGLMNYDTADMNTAFADIAAAGATTVRTWGFNEVTTPDGVAYYQSWSGSTPTVNTGANGLENFDNVVAIAKAHGLRLIVTLTNNWSDYGGMDVYVNQLLGQGSPHDYFYTNATVIAAYKNYVKTFVSRYVNEPGILGWELANEPRCLGSTSATSGTCTISTISTWAAELSAFIKSIDSNHLVAIGDEGFFNDPGNPIYVYQGSLGIDFDANLNISTLDFGTFHLYPDSWGESDNPFGTQWIEDHATAMLASNKPVIMEEFGTTSNQSGVYATWYSTVLSTGLTGDLIWQAGSDLTNGPTPNDGYAVYPGSDVYVLDTQHAAALKARDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUC5</accession>
    <name>A0AA38JUC5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_987035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUC5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="231" mass="26688" checksum="4CE8FE82C21E6A70" modified="2024-01-24" version="1" fragment="single">IRSGFLPFNPLLNHSLVSLQTVELYHHLFMRCPRLGVQPFLRGLCDLQGVRFKNNFGVQFSSAYDLYIRLTESVRLRVLISLDRTTPNWRLLNTCPPCQYEVEGEEPQPIRMMLAVDGNNSLKRFERRERRDDGTLLGPSRERPDVRIGGGDYFLQPSQVDLWDEPNWGKWVDWSPLEKADRNPCTDRWSNLNEAKTAKSFGSFDVNGIFAGFCRHSFVLAFSDMIKTGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVM6</accession>
    <name>A0AA38JVM6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1049120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVM6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="787" mass="86409" checksum="7DE0BC9AD8B31F15" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVR1</accession>
    <name>A0AA38JVR1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_630485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVR1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="538" mass="60287" checksum="DF692C532CB47768" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWD6</accession>
    <name>A0AA38JWD6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1066092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWD6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="216" mass="24006" checksum="822A8650C06C3448" modified="2024-01-24" version="1">MAMFLLSYLPRAPRNGLLDEHSSEPRKTYISNPIKIDPHQQAALAAELAASELLMRQFLGGGSVQKNHNYLMEEQQRSAFVPSSPTDMQHRSRKSKALVSAQHSLPPPPTTHVIYPSAMPSMPVDTGYHTHHHHHQYAHHHGYMRSEPRRRQTSDSSSSSSSSLTPSPTSSTFDANESPSPMPYYQPQYGSDVGGHRMTAKGVNLKGRAMALFRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXF3</accession>
    <name>A0AA38JXF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1047766</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="369"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="585"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="825"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="842"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3737376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="859" mass="96516" checksum="50AED0F9C52B25B4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXQ2</accession>
    <name>A0AA38JXQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UreD urease accessory protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1114789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXQ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="316" mass="34654" checksum="C1E980DDB5B29259" modified="2024-01-24" version="1">MPGSSTSISKIQAGGGRITLSSHGGKAWISEFSATYPLKLLSPRLSDNTVAIVYVLTYGGGLVGGDCIELTVNVESDTKLLLLSQGSTKVFKDRPQQRLASVQRSDYASRSTPGQAPATLQIMNFTVSSQAALFLLPDPVTCFRSASYSQIQTFRASKDATLVILDWITSGRKSLGEDWVLSRYYSVNEVLIAGKRVAKDVMLLENNEFNSDSRLNRSLAEKLSPFACYATVILRGPLVEETIAQLTTRYGGISIMQRKAPEDLLWSLSSIGSDKENGVVVRVAGKETEMVKDWLKNTLRSLEQHIGVDVYRRAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JY06</accession>
    <name>A0AA38JY06_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1045935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JY06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="401" mass="43859" checksum="E2AFC1BB1A717295" modified="2024-01-24" version="1">MLAEWLTTVSFVFGGCCSNAITLEQLTSQFPRAGSLITFCQFAIISIQGLHRHVEWTSYGPRLKPRRIPLMPYLIQVVLFYLVSLLNNAAFAYRIPMAVHIIFRSGGLVVSMILGWIFAGKAYTAAQVMSVSIVTLGVVLTTLSASESSSNMMHESSTPMYLTGIGILTLALVFSGFLGLVQDYTYTTYGRQSNSTHGSDKASHAPAWQESMFYLHFLALPMFITVRKDLISQFHTLSKGPVASYTITVPPSISATIRPSLSIPPPSSILLHPKSSSFLSFTNVETSSTSSFIDTDNLFLRLQLPAACFPLLLNTITQLLCAVGVHRLTTQVSSLTVTLILVVRKAVSLIFSVLVGWGRKTGHPENVNMNMMWSGAALVMLGTLGYSLATNARNSKKRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1P8</accession>
    <name>A0AA38K1P8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF423-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1129233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1P8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="12871" checksum="BE88E11871EE535D" modified="2024-01-24" version="1">MSSAPLLPRAVTGTPSLWRAGALITAAAIGFGAFGAHGLKQCKDITPDRINAWNTAAYYAMFNGLGLLLISLHPRFAVHRFAGPAIITGTLCFSGSIFALTLNHDLKFLGPVTPMGGLMMIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRG6</accession>
    <name>A0AA38MRG6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1032192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRG6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041304660" description="Vacuolar sorting protein Vps3844 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="243"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3719060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="351" mass="37879" checksum="63B26EE7C3D470F3" modified="2024-01-24" version="1">MMNLLRLGILLSIVQLSLAVDIYLNPAPVSLRNSLSPEDASLALSQHLGLELFEFLQDQSRPMYNGDSVDFVAAGQKNALIVTMEQFDASVILPSYLPPSFQLSVPEYAHIPSLSSVISTYLHRARYVYSAIYEADLSFWNPSELLSLKAFLTDAASSAFATLDFTSLADLRNKYGADSIEYERAAESTRAFFKDALENGEQLQLAILTYPSPTRILRRAAPSQVPLPGHASPQEPIGSISTCFASADSCNNATSSCTGRGQCVEASKSGRTCFVCTCSATKTGQGNKVKTEVWVGESCERKDVSGPFVLFVGSTLVLLILVFGSVSLLYGIGEKMLPPTLTGTAVNAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS83</accession>
    <name>A0AA38MS83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mago nashi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1090571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS83"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3724320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="158" mass="18468" checksum="1388DDAF19E0288D" modified="2024-01-24" version="1">MSSSQTAFVSNSPDNDPFYLRYYTGHSGKHGHEFLEFEYSHGRLRYANNSNYRNDSLIRKEMWISPLAVKEFKRIIEASEVTKEDDTNWPKKNIVGKQELEIRIGNDHIAFETAKIGSLVDIQDSEDPEGLRVFYYLIQDLRCFVFSLITLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MT00</accession>
    <name>A0AA38MT00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1080293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MT00"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="295"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="366" mass="43391" checksum="8F89CA7BD46998CB" modified="2024-01-24" version="1">MAQKRSFYSPTRPPTLAMTELVKMTLDHHHTADLITKWLEHPNDIYLDWFYSRREQKYDRDQRQMLLWNKGDFLLENIFCRTVDTGRLIPLRTWTTHVYCHCSIHDRKRTMMRVVFTMLPELMLLRAMHDRGCDEIFIIVTDLQRQEMDEVTEYFKLVCRHAFGSCKPGMEKRIQLEHMRITHAMHRQRRTPCFPQIDLALRAILYEKRPRFVILFSPPPTSYSQILFTHHSYVPDEEIFFEYPSGCPNPCCTDNCEMLRFPRRGLETAHVLEIKRGGKFGKRVKQKTMCNWIECDVCFSEETLPKSTSGSSEGTESSENGTDPSVQRVVPGQLCSQCRLVRYCSLDHQRRDWPEHKKVCAKMQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU31</accession>
    <name>A0AA38MU31_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000173">
        <property type="protein sequence ID" value="KAJ3709526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU31"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="843" mass="94710" checksum="D07DAF2B56DCFF15" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU87</accession>
    <name>A0AA38MU87_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000144">
        <property type="protein sequence ID" value="KAJ3710133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU87"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="120" mass="12794" checksum="BDC711C8CFFC5028" modified="2024-01-24" version="1">MSTTTEVPASRARARLPSQPTRYTPEEGEIAEEGPQQGPSDRHSIVGFGEAGNSSTQNRSRTPTPSGGAGKGKNRSDSNQRGELNPRDSISNVGSSDEGPANCSARQHLSWDILIEVKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUI5</accession>
    <name>A0AA38MUI5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1106428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000110">
        <property type="protein sequence ID" value="KAJ3712320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUI5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="18893" checksum="7F91CBC7B4483015" modified="2024-01-24" version="1">MPDHAARNAKRIKGEESLLYSPSQPIFIRSVFHRLNASNSQKCTGLPSPLSNPHLAFPITRNSPCLQRRYRSRRCTLSRPRTCQIATADLRSAVTAVGAGIMLLTALSGREWNQILYVRIFVSVEWSSSCSLFRTHSLYYFTIPIMLCRFEILAFSVYYALDLVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUL9</accession>
    <name>A0AA38MUL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_995452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUL9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF5">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="98" mass="11129" checksum="CEC715F737C27FF9" modified="2024-01-24" version="1" fragment="single">VMKAILNGVVLAESEETKVIEGNHYFPPESVKKDYFTDSDTSSVCPWKGTCSYYDATISGKKVPDVAWYYPSTISDRAKPIENYVAFYKVQMFFSYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUY8</accession>
    <name>A0AA38MUY8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1228052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUY8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3714550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="244" mass="27970" checksum="FF662C8728FBE370" modified="2024-01-24" version="1">MVIYPLSSLRLIIILLFSTSAILDVMSIPLAGRADASSSSRRKKPSTTRDPMRLFLVRTRKSGQDTRRLEPNEADEFADDWSIYFGYASGFTVVCDNANVPVASPNWPWKVSPLKREYDTSGTFTSIAETLAEISHGIWRSKAINIKDHLEKNLPVEGRFSYLDAVMQYLWAREIITEADIGKWNTRVQAMLNIERSEEYVTKMKEIKYDTVEGQQLKLQEEEQGQCPNFDFNHFLNLDHHESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV54</accession>
    <name>A0AA38MV54_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1101984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV54"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="14978" checksum="EF5D4BE9D6398E18" modified="2024-01-24" version="1">MPRQSRGRSSVSRPAAAPAQSRGAHTTTVPSGYASPARPPAPVTHANPAPATATSSGQPGMLAQMAATAGSVAVGSTIGHGISSMLFGGSSAPAPAVEAAQASSAPQSRTGINCDVQAKDFTQCLEKADLPSCTWYLEQLKACQAAAAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV61</accession>
    <name>A0AA38MV61_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1006878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV61"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3716333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="540" mass="58860" checksum="AD8825D7D0E99536" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV90</accession>
    <name>A0AA38MV90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW/HypB/UreG, nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1063733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV90"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="261"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="350" mass="38589" checksum="9E63DAFF55FD3019" modified="2024-01-24" version="1">MTKATIPITVFTGFLGAGKTTVILSLLPKLPKDYKVVLLKNEYGDVEVDSKLAKESSLTAVSEILNGCMCCVLVGQMQNALFEIRDQYHPDRIIIECSGSAFPATLAFQIREMEINTGGDFKLDSIITVVDAENFAGYEDTSPTAKMQASYTDIILINKWESVSDRQLDTVLDHLHTLNDLTPKLRCDGRNGVDPNLIFGIESKLFLDKNAHNQDPSHIEEVETLTLYRGSAAGLGHKHDDDHVHADGHNGILGNRSPDSHQSIPLEKLKESLSELSKESVWRVKGFVRVQGANVETFILNWAFGRYDLTQSDPSALTEDSSVRLTAMGERGELRRAIGSLCKTLGLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV93</accession>
    <name>A0AA38MV93_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Flap endonuclease 1</fullName>
            <shortName evidence="13">FEN-1</shortName>
            <ecNumber evidence="13">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1063835</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
            <location evidence="13">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
            <location evidence="13">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="13">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV93"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 13 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="271"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="405"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3734159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="447" mass="49417" checksum="5235E7433BE3649C" modified="2024-01-24" version="1">MGIKGLTGLISEHAPQAIKEHDIKTLFGRKVAIDASMSIYQFLIAVRQRDGEMLMNDAGETTSHLMGFFYRTIRIVENGLKPAYVFDGKPPELKKGVLSKRFARREEAKEEGAEAKEVGTAEDVDRFSRRTVKVTKQHNEECIRLLQLMGIPVIVAPSEAEAQCAELARGGKVYAAGSEDMDTLTFNAPILFRHLTFSEAKKQPISEIDLKAALDGLNMNMSQFIDLCILLGCDYLEPIKGVGPKSALKLIREHNGLKGVVKHLRAKTAEKEKAAAAVEEEEEEEEEPAPTSDVEQPDGSDAEEASSSKTKSKAKKRGGKGKGKGGVSMPEEWPWEEAKELFMKPNVTPADELELEWKNPDVDGLIQFLVTEKGFNEDRVRKGAEKLQKFLNTKQQGRLDGFFTVTAKPKEAAKGKGKEDKGKKGTKRKGEDQERGASKGKKSKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW27</accession>
    <name>A0AA38MW27_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1160499</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW27"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="172"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3715294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="353" mass="39075" checksum="59AF12EA45E1C085" modified="2024-01-24" version="1">MSFPESYRLVDSRGEPVNHENNDSFNGQELYDNNPYRPPQYEGYKPPELNESYAPQTYVPMHVNLQDPRAQIARTPSPTPSEAHALEEIGNHSGIINWKRITSRKFWFSKEGLKYGITAAVIITLVVLFAIYHEDIVIYLTPATQWCHDHKFGWLIPVGILFILSFPPLFGHEIIGMLCGIGWNIGIGFLIVALGTLLGELANFFTFKYCCTARAQKYEKKKLSYAALARVVRSGGFKIALAARLSLIPPHLTTTVFASAGMPIGTFLAAAVCSLPKQLVTVFIGVLLEDSINGTSKKDKIASITVAIVCGVITSLALKYVNKKMDEVMPAIIYERRKARQSAHLKALSGGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW61</accession>
    <name>A0AA38MW61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1098157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW61"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="456"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3718577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="515" mass="55807" checksum="66CCA8A33839CB16" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWD2</accession>
    <name>A0AA38MWD2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1159199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWD2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="387" mass="42537" checksum="238B0DD91746E07F" modified="2024-01-24" version="1">MTLGSEYPHADFINSSFAPENNNIGLPSLDHSLPHSTNSASFPINVGFPSSNHSLPHSANSTLPFPEDYGMFYATATVPQHLYDPSLINDHSQQAMYSVPIALPYPIVSDVGLGFGHMPFPRRRLSCSSTLTSVEGRVFKPNTTFAQSSAMGHHSNDLTGDPQAQPSGSRPTTNNHDGQSSSSPSASTPSISASGDRIASRIPHDATNNSSAGSLMPERNGRTTSQRNSTPYTTQNRASKRTRRAPEPEFVDVRKYNRELCRWRMSSGFECQHDFGHDNRKSVSAHALSHRADAKEEEELNGRIPQKGNFVCRWTGCGSGAKGMAEDAFARHFVHHHSPIRTLCLRCGQVLARVDCQKRHRETCCLDNSLKKPELKKQAYATHAVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXE6</accession>
    <name>A0AA38MXE6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="573" mass="64746" checksum="AA0C08FD96A2651A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXV0</accession>
    <name>A0AA38MXV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_988229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXV0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3736994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="368" mass="41642" checksum="8B85593295F38B51" modified="2024-01-24" version="1" fragment="single">FDAGDDYELTHTLGAGAYGQVVAAVHKPSGRRVAIKKIMPFDHVVCALRTLRELIFLKYFRETSCNDNIVTILDIIKPKSIESFDTIYFIQELMQTDLHRVIRTQCLTDDHCKYFVYQTLRGLKTIHGANIVHRDIKPANLLVNDNCDLKVCDFGFARSMSTCERTGKGLGLDAPGVMTEYVATRWYRAPENMLSNKTYTKAIDIWAVGCILAELLSGRPLFPGRDYVHQVDLILDVLGSPSTEEFSTITSRRAREYIRMLPLKRPKSFSALFPNASEDAIDFLNRTLTFDPKKRMNVAEALEHPYVAPYHYPEDEPCGSPLAAENFEFDLQKEQLSKSELKRLLYEEISSFQSDPFASTEATAVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXW8</accession>
    <name>A0AA38MXW8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1157612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXW8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="259" mass="27871" checksum="8A3F4F41C3B879D0" modified="2024-01-24" version="1">MDSKALSSKPSTLASFTNYFRPHRGEAVVRLRSNAFGLVSVFISTWLLPVPSVVSAMRMILSGNNTRTEFLAGNGSEWNVRKAVCLLELTIVAMLIYNVLEAFYALQYPRKPLPPSGLSPAKKSNPLGVFSPESTKKPFRILSPNSTPTSASKFQFFSPSQSLALSESRSSQYPPSPVSSPSRVIRYSMPPKGGSSEGGVNASILSSTSTIPPTPSPSSTLASAYRGKHSSSFHGGRPMDGLFLSQITLSGDDDDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYB2</accession>
    <name>A0AA38MYB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1133626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYB2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3724113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="408" mass="46606" checksum="F4F2662626334F8D" modified="2024-01-24" version="1">MTWASSGGQTKSEAETTRLVNDALLQDDFDPADLNGFNAHTENIRLDRSQISLSTLPKFQESAVTIEVPSGDREIGSQDFRIPGLQYRSILSVIKSIFAEPLAEKFHFIPFKLFRALPGSDLLEQHDVVQRLAAPLEQLDCKLERVVLGLMFWSDSTHLASFRNANLWPIYMMFGNLSKYIRSRPNSGACQHIAYIPSLPASFHDFASSFFTKWSIAKQRKSLLTHCRRGLMHAVWKFLLDDEFVHAYNYGIVIQCPDEIEHRFYPQIFTYSVDYPEKDKGKCPCPRCLVEKSALDQMGLYHDLRNRITKFRELLTDAVTRARDFIYRLGFPINGTAVDNLLKDTSSIPTINSFVACLGTRFNVPQMLAVDLLHEIELGVWQTLFTHLIRMLYAAPHGPILVARLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYH0</accession>
    <name>A0AA38MYH0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1193968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYH0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="3"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3728003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="395" mass="42820" checksum="AF95C8BDFE90B1D8" modified="2024-01-24" version="1">MIQFAALCWCFILEGWNDGSIGPLLPVIQAYYSVGFAVVSLLFVVNCCGFVFGAGMNIWLNERLGFGKVMVLGSLFQLSTYAIQSPAPPFPAMVLSFFLAGLGMSLQNAQANGFVGSLKKNKHAKLMMLHASYGLGAFCSPLLATHFSQTRHWSFHYIISCGIAVSNTAVLCVVFRFKRQEDLLRQIGQEPNEESPSNALPSHNLYRQIFNIQAVHFLAIFAFIYVGVEVTIGGWIVTFIIRERDGGPSAGYISSGFFGGLTIGRLALMYVNKKVGEQKVVFIYVLLSIGLEITIWFVPSIIENAVAVSFIGALLGPLFPILVGLGARILPPYLFTGGMGWITGVGTAGSAALPFVTGMLASKYGIKSLQPFLVVMMCTLAGIWAVIPKARRTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYK3</accession>
    <name>A0AA38MYK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1089042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYK3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="344" mass="37830" checksum="64C0BE15AAB360E3" modified="2024-01-24" version="1">MISLLSISESGLLSRSSGLDNYQRWTKGCSPKFGSVVDDIDIIDGRIEGREASSIGCQLLWVGPKRTDKVILHFPGGAYIFPVSEMVFKFWKYAQLEWEKQGLEVGIAILSYTVGPGKDAAFPIQLIQAIHALKHLLSMGCNLSDIQLIGDSAGGNLVAQLLLHMVHPLPLPSNLVPTLDLPPGARLRGVYMMSPWVSLSDPDQWGSSMHTKDNDIIIDKTGRRWGDIYVNNIGNGILSNVSPAQLLPYAEPILAPNNWYSYLPQIVDRILVSAGKEERLLNQVQALFDNKIKPYFGDVDGTLVLQDGGVHDDPMLDFAVSDVPLGNPLTAVVVEWIKEGFIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYN7</accession>
    <name>A0AA38MYN7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1139710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYN7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="160" mass="17801" checksum="ADC3291C20D3274A" modified="2024-01-24" version="1" fragment="single">MKMETIRTLPIYYMITTTKTALTGLLIGYIHQYMAVVGIQIRHLCFGKYGGCTFQSYVGLSVAGGIWQLIVLQGIVRKAEKILGSKKIPENGDSLVQVSSMPWYSRKCEPRASKAPVSSLTPVSNWVSATWNLNTNKEEYLRSRKTSTGAFKRISGWASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZR1</accession>
    <name>A0AA38MZR1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_997863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZR1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="243" mass="26968" checksum="0A7D17E97B02DA3A" modified="2024-01-24" version="1">MSAYNRLVKLTVISDVICPNCNIGQHELIGAISYCQDTLHLPITFEIEFLPFRLIPTRILPDENTPKVSKDEFFNSTVGKEPWAAMQASIMKWSQEKNIPIAFKGLVSQSTRAHRLSRKAYQIGGQNKQLPFLCAVFRAYLEEEKDVADLDVLSEISEQTGVMSKQEALDFLHSDELLEEVNTMCEKVRSKVTGVPMTIIDGKWCVQGGQSSDVFIQIFKKLADTGVSAAPSPFAAPVVALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0B2</accession>
    <name>A0AA38N0B2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_293106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0B2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="223" mass="23126" checksum="428E8EEB94E01D30" modified="2024-01-24" version="1">MPRKAASTTERSADAPAPRRSTRIKEMPKPEPPVTKAPAKPRAKKSDKDKEIKPEGEEKPKAARGTKRKVEVDEDAKAEEDGAAKAPASKKAKPPSKAKPESKTAATKPASKAAASKPPSKVKPSSKASAKPASKSSVKPPSNANSRAGSKKPSSKVCAGSDFPLSSSNRKLSPIPLTSSTPSMTDPFQAETTVPPTAANASVDETIAEDPAAEAAAEQEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0E4</accession>
    <name>A0AA38N0E4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_284286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0E4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="379" mass="42458" checksum="FD2F375C781B2E63" modified="2024-01-24" version="1">MYNNHTSLPYHSFINHASVYDGIPGAVLLDGILQSFLLGFVLGQATKYFSVFKDDRWQKRLFVGVVVLLSLTQTIIEDFKLWQISVNKSSWAHSQFVWTGVAINGCISWLCEIFYIRRCWKMTDHNPWVLYPLGTLSITVIIANFIQAVCLPLVLSKTDPHSGNYFGGDTLMESLQFVFSYWVFGSLVLDLIVASILITTLWRAKTGLEDSDRVVWSVITLTCESAALPCISMIAAGSLFHSNKEGNLVLFFLLLSGKLYSYGLLRTLNSRDGFRLRLNSNNLGRATLGDCHWDRTNGSHTHLSTAVATISEPPKSLDTTSLPHFYEAVHETRRSDEVPHNEMETLSPTLSSNPRTSSSSFGSRSHPTRRSSSHSYGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N114</accession>
    <name>A0AA38N114_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1067460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N114"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3733515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="524" mass="58001" checksum="835E4DD3B85E094F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2L1</accession>
    <name>A0AA38N2L1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1151451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2L1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="57792" checksum="ACDA972BA3942AE1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2S5</accession>
    <name>A0AA38N2S5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1151502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2S5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="402" mass="46078" checksum="B3D10BF0AE449850" modified="2024-01-24" version="1">MSKRIRSSSPSSQLDQEQEHQKVPKMSASYDNPSGDALRLFGENQQLHATIAALTSQVAVLEETATELHTQTLHNEIEEMSNYIEHLESSLDHRINANAPDSDLLGFELELKAVKEQAFLKQKMFEKQLSSLKTELHNSQIANRALARRILKISRCDASVQTDPNFQSAGKKEGLANNTLVAQLHSTVPEVMPIKKPQAELPVNQEYQLNLMAVFHSHSTDEAFPNWFEKGFEYVSDDFGQQYAELLHQYILFEASHHWVNATHGLKKTKPQQLINWTTQGKRKPAAALPIIAALSSIETIQKFAEALWTWWCELQPDWRIISRNRPEPFDKFVDNFLLLDKRGQNGWLGLIVCTKWWRLGLDSLDDNIRQELEADWFRVVEDMTNMLKGMVEMRNCRITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3G6</accession>
    <name>A0AA38N3G6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High mobility group box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1063130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3G6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22012">
        <property type="entry name" value="HMG-box_ABF2_IXR1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="149" mass="16634" checksum="E517DB41143485A0" modified="2024-01-24" version="1">MAPTVDDLRSQYENSLLAVAQSMRDAAEAAELFANAIVNTPIINGHAKEKGTAREEDAVDGKRKRAKKDPLAPKRPASSFFLFQNQIRPKVKEQHPNLPSHELRKLLAEQWNTLPEEQKNVSVFAVFSVSCDVLLFASSNSTSNKWRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N404</accession>
    <name>A0AA38N404_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_514039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N404"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="174" mass="19880" checksum="E2273792B7BB5448" modified="2024-01-24" version="1">MADFYTTAKSTKNNSILHRRDNLIAYIIETPSRILHHERSTLYKGPNREPIGFIEFHGLHDNIVEINGRSFLPHRAHESNHLSDSKEFMASDGRTYKWKHHSHGVWELLTQDGSHTLVARYDRNNISVYPQAILVQDEVILTLIYMRQCKEKEDDAAMITATTSIGPVAGTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4B6</accession>
    <name>A0AA38N4B6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-Aspartase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1211319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4B6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="728" mass="78631" checksum="7FE2DDFF8CBE3804" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4B7</accession>
    <name>A0AA38N4B7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1056173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4B7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="616" mass="69697" checksum="4DFAADF8E741FFA6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3T4</accession>
    <name>A0AA38J3T4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_783379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3T4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="874" mass="94619" checksum="A77A0236134F5A7A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5B0</accession>
    <name>A0AA38J5B0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">X-domain of DnaJ-containing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1228577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000130">
        <property type="protein sequence ID" value="KAJ3710891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5B0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3710891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="371" mass="41393" checksum="DC1F7E9C37E77C29" modified="2024-01-24" version="1">MNLDKGTTIRNRILGVSVTTTTDKIEKAYRRLAIKHHPNENPDDPLAEERFKSIVVAYQTLSDRQLRSKYNEFGPKESTPEGGFVDPEEVSAAIFGGERFVGIIGQISLARDMKAALQEVEDAEETEGGEASRIQDGKGRPVLSEEEKAKKEEQKRKKAAERAAARAERVEKLVENLERKLGIFTESATGINDEDVTRSWKEICKLEAQELSHESYGSELLQAIGFAYVSKSKNFLATNQTFLGVGGWLHNVQGKYHVFSETAAIEIKALEEQAAEKGSQVLFKAAKLKIDSILRELCDRVFEDPNIEREGRAEGSGIADTGRSVWELGDWSECASTLAIRVVLPAEDLVTLHTIIRERLHSNPHERIPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6Q6</accession>
    <name>A0AA38J6Q6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1135102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000116">
        <property type="protein sequence ID" value="KAJ3711649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6Q6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="851"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="980"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3711649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1119" mass="121060" checksum="BA82DE022000F3DC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7H1</accession>
    <name>A0AA38J7H1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1007841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7H1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3714314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="373" mass="42686" checksum="4D75BC6B28F98A08" modified="2024-01-24" version="1">MQQAAPSRKPITKPLPVFDVGKDYELLYPLGEGAYGQVVAALHKPTRRRVAIKKVLPFEHTIFCLRTLREVKLLKYFSESCVNGNIISILDMIKPESLDSFKELYFVQELMQTDLHKVIRTQQLSDDHAQYFIYQTLRALKTIHSADLVHRDLKPANLLVNANCDLKVCDFGLARSVHPTTCEASTGGRVMTEYVATRWYRAPENMLSYNMYTKAIDMWAVGCILGELISGRPLFPGRDYRHQLELVLHVIGTPTLEEFHAITARRAREYLRSMPIRKKQNFKALFPLASADAIDFLQKTLTFDPKSRMTAEEALAHPYVAAYHDVEDEPLAPPLDPNYFEFDVGKEQLSRQQLKEMLYEEVVSFESGIKTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8C5</accession>
    <name>A0AA38J8C5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1081618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8C5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="443"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3731126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="569" mass="64438" checksum="53172FD4E20B5724" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8E9</accession>
    <name>A0AA38J8E9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1134697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8E9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7729" evidence="1">
        <location>
            <begin position="72"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="314" mass="33031" checksum="6FFAD12B4E96055E" modified="2024-01-24" version="1">MTSEKVFRRQETTDVSVSIATGTATATELATPTSTAAASASGSATATATTTVPATAQTLPTIPTSTPVLPIPFPQPWDSSITQNFSSQSCYNFFLNMTNSQDFRSCRPFGLLQNTSDDFADFQTNLTALNAVIWGTCNPTPGIDQCALNMAKFASSLQSACAEDLTDNNLFAVSTQQALNAYSLTQNTGCLNDPSTDSYCYVKAVHNTNPSDLYFYSLISGVAISNSTTLTCSSCTKSLMSLYVNALNANGSQLTELASVYGAAQALAASACGTSYAEVSTSTQADSSNGASSIRRKVYGICLTSLMLTFLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8V1</accession>
    <name>A0AA38J8V1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1134707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8V1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3715274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="260" mass="29998" checksum="3146A0F20409B3CA" modified="2024-01-24" version="1">MTTVLFQQKIRSRTWLFKSGKSPVIDSRMWHRFLHKYKAQRPTCSVKNHKVLKTGHYTRFWCSQDEARKKKPKKSQDPNVKQRDNVGMKRYPCKSLLVISYAERHGGPPTLNIHFEHHQPHVHYYDVRMPEGAAAIIRQNADTLTPVQIAQKVRHVYPSVTSQQVSSAWSELSKMFWKRSDDQITSLKTLLAEYKDDIDVFDVGRLPDGVEMVCWGLKKINDELKGKVVEIGIDATFGVGSNMTSCIIFIHRVSTCLHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8W3</accession>
    <name>A0AA38J8W3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_846821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8W3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3715289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="162" mass="18147" checksum="100AB399226380F6" modified="2024-01-24" version="1">MWIGSKWRGDPVKALVRWACDWGWWKILVGEAQRVESGSWDNIDLPFQVFGVVVVVVVVADVKVEIGVEGRCLSPVLPLSFSPSSSSSFSLFTSCSSYPSTALSFDPYHPCPLIFRSFIVLFPFPPTLRDQDRMRRTTPARASSTLSLASEAPMFRRRVSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J980</accession>
    <name>A0AA38J980_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1099203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J980"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="9">
        <location>
            <begin position="367"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="471"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3717665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68753" checksum="56FAEC48BDD38CBD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9N7</accession>
    <name>A0AA38J9N7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1135031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000109">
        <property type="protein sequence ID" value="KAJ3712355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9N7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3712355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="502" mass="56382" checksum="B340465CE9CE2217" modified="2024-01-24" version="1">MTPTSVKDEKGSSKSDVSELELFASDNGDGALDPVESLHLLRTAWLIRAILSIQYLDKSTLGSSSILGILTATHLDANELSTVFYLSYLVFEYPQNLALQRFPVGRWLSVNIFIWSVALCCHAACRNFRELVVVRIILGMCEGSITAGFLLVSSMFYTRNEQMLRVGYWYLMNGTAQIATGFISFGVLHIQTKRFQPWQWLMIITGILSFMTATAFWFLFPDSPTTAWFLTPEERATAIQRVKVNQTGVGNKHFKKEQFYEAIRDPKTWGFALFSGISNVTNSISAQAPLITASFGFTYLQTSLLGIVSGLIEIFTIWTGVNICARIPNSRAYIGAIYILPNIAGLLMVNLINWNDRIALLAGQYLNGLGTTSFVLMLSWLNAVTAGQTKKITVNAIMLCAYCIGNAVGPFMWKQKYKPRNHVPWAVIGACYVSCITLLLLLRLYMSRENRKRDAEPQDEDADTEVYVKQETADGEMIKMLKVDKGFLDMTDVQNRSFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAB1</accession>
    <name>A0AA38JAB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1104318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000093">
        <property type="protein sequence ID" value="KAJ3713999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAB1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3713999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="603" mass="66050" checksum="D4824DE9AD88EF71" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB65</accession>
    <name>A0AA38JB65_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP synthase regulation protein NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_582949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB65"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3725007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="652" mass="73817" checksum="5F80F9264C387F89" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBS7</accession>
    <name>A0AA38JBS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="17">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1137897</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBS7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="13">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="460"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="808"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="931"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="280"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="973"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3733451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1186" mass="132131" checksum="4CCCB65EDB022841" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC90</accession>
    <name>A0AA38JC90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sure-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_541609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC90"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041419133" evidence="4">
        <location>
            <begin position="23"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3727295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="310" mass="31977" checksum="394AA63F859B6F46" modified="2024-01-24" version="1">MSLLISLFALLTVLQISSLAHGEKILIGNDDGWAVAAIRAQFNILSETGYDVILSCPAINLSGTGSLSAPPTIVIIPCEFDTCPILSPAEGFNASDPRLNYVNSFPVDAVNFGINTLAPELLGGPPDFVVSGPNVGNNLEALILSGTIGAASAAAKAGIPSAAFSGSSDSLSQVSYTTLDSDPTSTNSIASNIYSILTLKFLDALLSDLHPGPILPAGISLNVNYPSITNCANEADFDFVLTRIVADPSATDVETCGTTHLPAESDVVALEGCFVSVSVFDASTLSDVDAATQEAVLNRLIDLLKCVPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCN1</accession>
    <name>A0AA38JCN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1062585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCN1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3734422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="271" mass="30268" checksum="769E5A85922F7DE4" modified="2024-01-24" version="1">MTLRSAATVSIIGLTCKAFLNSGLCKISVNGLQHLAQALENAHREHDRGIVTISNHISTLDDPVTWGILPVKYYLRSSRFTRWTLGASDIMFTNRVFSSFFRHGQVLETFRGKGIYQPAVENAIEKLNQGCWVHLFGEGKVNQPDTYQKDENGLATLPRFKWGVGRILSSTAHPPIVIPMWITGFDKLMPEGRAFPFKYFPRIGARLSVTFGGPLPLDHIQSIQNRVSSGRQPEETQIELDARMRTEITTAVHQAILDLGRRVSGPSLANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCP1</accession>
    <name>A0AA38JCP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_302285</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCP1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041289435" description="tripeptidyl-peptidase II" evidence="12">
        <location>
            <begin position="20"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="13">
        <location>
            <begin position="215"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3732594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="568" mass="59173" checksum="83DEFF131ACA87BE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD80</accession>
    <name>A0AA38JD80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1161267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000103">
        <property type="protein sequence ID" value="KAJ3712992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD80"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041361692" evidence="1">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="126" mass="13735" checksum="EC92F4DD097CBAA6" modified="2024-01-24" version="1">MKLSAVTILTVLCKLTYTTSSPVQTSDIVYVPRAHDPSPPFIEFGARDGDEPAAPFIEFGARAENEPAAPFIEFGARAENEPAAPFMEFGERDGKYIVEPTLLEIGQSHKVLKAVPTVDINSWVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDN7</accession>
    <name>A0AA38JDN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1000160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDN7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="72484" checksum="0623BB5820FE550B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE02</accession>
    <name>A0AA38JE02_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1002427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE02"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="187" mass="21138" checksum="1C7C352D4233398C" modified="2024-01-24" version="1">MTTYGLPYFLEDKTGRLSGSEFVDIHDRLRLTYRLSTDRSSSHTAFMIYNTSSHISHPSFLQALVALDFGPGHALGTVSFSSKICLPMKKYLVKVSSKGRFVSVFYLFIASDSQEYFWSWRSQANQEWTCTNTSGYLTAYYSLKTPGEPQYEGSSGCSLTIEESFGHLAPEILASLMILRHMSEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEG6</accession>
    <name>A0AA38JEG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1079905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEG6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041396473" evidence="1">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="180" mass="19330" checksum="388A908A3151598B" modified="2024-01-24" version="1">MKLLTTLIASTLLLFVAASPTTRDTVICAGEEVLSETYIGEEKNVKLQHITCPATPVKRALAPRQTDVCGNTCTTNCFTPSGGGPDPNDCHVIADALRFDSQNVGALFEIGTGSNNTIALTYSSCESFYVNQDAVTQIYCRTDWAAVIDYVAPNCQATQNAHGGNCVATDQQFFIQVQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEJ2</accession>
    <name>A0AA38JEJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_809619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3716755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="325" mass="35546" checksum="D729F2C2EFF05F09" modified="2024-01-24" version="1">MSDAQIPPFDRMFMTGIWIESVLYGVNTVIFAAAIFVLTRMHKAGKSSAGFLLVTSIFLFSLSTAYVSVCLRQLLEAFIWGPPGGASIYFANIQDRLSITKLALYEVNVFTQDAILIWRMWVVYNNRWMVVILPIAMELGHVAAGIYTIRRGAYPNISVFDPFVHRGAIANWTLDLAVNIGVTLCIAYRLWSAGRFLEEFGIRRSKHPYIGIILTIIESGGIFATATLITVSLYLSGNVAAVAAIDSVVQLATITPLLIVVRVGLGLQHGISANVMTFEAATRDTLASRSESLHIDITKSQNTSGDDTLYPGNNSSIRDMKGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEM7</accession>
    <name>A0AA38JEM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1159985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEM7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="63"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3716815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="355" mass="38599" checksum="8F665CFB12D39374" modified="2024-01-24" version="1">MTSAQDEKHTQLAKVEDVAAPGFSPEQHQLVREDLEIDDSEEASMLPSPVVAQTPRQKPKLTAAIIIPIWIVLSSSVIIYNNYLYNTLHFRYPVFVVTWHLTFAAIGTRILQRTTPLLDGVKDVSMSKDMFLKSILPIGFLFSGSLILSNTAYLYLSVSYIQMLKAFNAVAVLLVSWTFRISEPNRKLALIVLMISSGVAVASGGELKFNMFGFIVQAASVGFEAARLVMIEILLHGLKMDPLVSLHYYAPVCAFLNLAALPFTEGLAPFFELARIGPFILITNAAVAFLLNVAAVFLVGAASGLVLTLTGVFKDILLITGSTLIFGSTVTAIQVFGYSVALGGLVMFKLTGNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFB9</accession>
    <name>A0AA38JFB9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1066390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFB9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="165" mass="17558" checksum="5BA8BD634BA7A0BD" modified="2024-01-24" version="1">MAPKLDPNEVKIIYLRATGGEVGASSALAPKIGPLGLSPKKVGEDIAKATGQWKGLRVTVQLTIQNRQAAVSVVPSASSLVIKALKEPPRDRKKEKNIKHSGNIPLDEIYDIARTMKSKSLAKDLSGCVKEILGTAQSVGCTVEGMPPHDVIDQINSGEIEVPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFE2</accession>
    <name>A0AA38JFE2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1131139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFE2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="448" mass="48259" checksum="C8DAED384A2EAC11" modified="2024-01-24" version="1">MSEQTALLSTTADANNYGGGAPTNQSLPTFNITVRSVVWGVLTTLTAAALVVLLFFQDNLPDNVKTLPWVGGEPKDSMIAALAILEKAPVIDGHIDLPILVRYGGYANNVSAVDLNSRMPAHVDIPRLREGRVGGFFWSVYVQCADPDAEGANFLKATWRVRDTLEQIDVAKLLIEKYPDTFQFAQNAADIRSSIADGKIASLLGVEGAHQLGNSISVLRQYQALGVSYVTLTHTCHNAFADSCGLAPGKEPLHDGLSPLGFSLIDEMNRLGVLVDLSHTSDATAIQALNYSKAPVIWSHSSARAVHNVPRNVPDEVLRLIGTESGRDAVVMVNFAPYFVAPEGLATVKTVADHVDHIAKIAGKDHVGIGSDFDGIEIVPAGLEDVSKYPALIAELYSRGWTKYELAGFTGGNLLRIFEGAEKVSRELKAAGVQPVYDLYSKRTDIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGA7</accession>
    <name>A0AA38JGA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1124788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGA7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000061">
        <property type="entry name" value="TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="8">
        <location>
            <begin position="213"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3721327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="320" mass="33426" checksum="14CF03320EA11C67" modified="2024-01-24" version="1">MSAPQVPDAPYAFNSPSPEPSAVPTVTTHAGPGRPRGSGAKRGRKPRGAILAGVASPRVTTTEMTSSTSPAFSSSTYTPHVHWNLANTTGTSSPGASGSSSVLPATGIAQSRLGSSITSGISAYGQNLQTSSTSALGTSSGATTGIGASLNLTNLFRMSEGVGASGTGSYPRATGLGGDDEGEGDDELLPAMADDDYSAQLSWQSQSKDNLKVLMENFSPDQYDRFEAYRRHALPKQAVRKVIQQVTGQQASQPVAQIVAGFSKVFVGEIVEKARQVQARRGEAGPLSPDHLREAYRLYQQETGNVGAAKPVRAKKLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGF5</accession>
    <name>A0AA38JGF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1158496</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGF5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041358174" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3722055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="346" mass="36842" checksum="2AACC016494B68EB" modified="2024-01-24" version="1">MTILQAISSLVLCLLALPSVAAHGYLAYLGIVDGQSYTNYTGNVPNADPSPSVIRQVSDISPVKGASNPDLNCGLNAQFAQKVASANPGDLLVFDWRGGDNTNWPHNTGPMLTYMTSCGRNRDRHERNFKRFSRLGPTERDERCLHQRYSTIYDFPGNYLIRHEIIALHLATELGGAEFYPACSQVKVGGSQTGMATDSEMVLLPGAYTDTDPGIYDPDVYSSNSYTFPGPPIAAFVSAAASSSGSSSSSSTSSATSPASTGSTSGSSSSSGVQSVCKLQRRTQSSAESVARRSLKHSSHLPLGIQESRQQKGLRLHSLWGDLVTTFSALRLGGLEIAKGGQSAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGH7</accession>
    <name>A0AA38JGH7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1156688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGH7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3728125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15982" checksum="6850F713081F4951" modified="2024-01-24" version="1">MSSVIEVPQGSSYVAGALLSTVFLLAGQSHVVSVHRKAAGIKYPQTYAEQRETEASVSALKFNCAQRAHQNTLENLPIVYATTLISALKFPKAAAAACVFWSLGRVLYTRGYVTGDPAQRLKKGGALHSLAILVLLGTSLYTAGSLMLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGR7</accession>
    <name>A0AA38JGR7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_872818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGR7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="160" mass="18642" checksum="0B16B90BF2CD9E1E" modified="2024-01-24" version="1">MLSKHGPMKAIFSSGQQGILREHSNYDFIKEKKNALYDPLNATKMVNSSRMFEYDELISYFIVSCAALLAYDYCLTLDLERKFVWSKPCKWSNILYLFQRYLPLVDTVILFTISTFSSNTGYCDSIFNASLCKYGSLLADLPEMIFDYRVTLRRNELVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGY3</accession>
    <name>A0AA38JGY3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGY3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="596" mass="66338" checksum="6C8EA1BCE3288A7F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH85</accession>
    <name>A0AA38JH85_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1083739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH85"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="263" mass="28736" checksum="EEF444C8E8620A3C" modified="2024-01-24" version="1">MKPSNISPRPILKRSPSTCHENDSELPFYGIQAVHFPPSPSLSRFYHAHPSSIYDRSPIVVSANACALPERGCPGRTYTLDERNLSASQQPTISAPPSRGGHLHPRALSQWPVQYLPNGSPQCPSLIPDLSSESEESDGFISPPPETSFASFGPNSYPRRADKHPSQLSLDNAVYFTAKLDNIQHPSPVESREKSRPDRDRIRSPAGPGEVAADDPGYDDDRDVPASSPRSISPRKNRSRKHLSSRAKVSFDDKSDGGCLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHH9</accession>
    <name>A0AA38JHH9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_997741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHH9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="342" mass="37760" checksum="79960A5D67D1AC3F" modified="2024-01-24" version="1">MSLNTNIELPHPPSDSISSLSFAQNADYLAVGSWDNSVRVYEVSLQGHTQCKATYTHRAPVLSVCWNEASNRIFSGSIDNTGLMFDATTGQTTQVAQHDGPVKAVKWVNMPHAGVLVTGSWDKTIKYWDIRTPSPIATVQLPERCYTLDAIYPLMVVGTAGRRILTFDLAKSPVVFGNNVSSLMMQTRVVTCCPDKTGFAVGGVEGRVSFNYIEEKNKRHNYSFKCHRQNSSPQKVDQSLVYSVNDINFHPVHGTFSTCGSDGTAQFWDGAARMRLKSAYCCFSRASGPIACSAFNRTGSMFACAVSYDWHKGFSGMTSEQPNKVTIYAVKEEDVRKKVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHI9</accession>
    <name>A0AA38JHI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1177953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHI9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="355" mass="41553" checksum="91047766A13959E2" modified="2024-01-24" version="1">MSISFETRRYVVFSILSLLGLLYATILLRGGLRQSSSSGTPILAELGSTIRRENATLVILARNSNLKGVISSMRNLESRFNHRYQYPWVFLNDEEFTNEFKGLVLLETNAPVHFGLIPKEQWVQPAWIDEGKAEESRHRLKEQNIIYGDSSSYRNMCRFNSGYFFHHPLLQQFKFYWRVEPDVKYFCDMSYDPFQYMIQSNQTYGFTITLLETPETVTTLWDSVKEFMTKYPQYIANDNALEFISSDGGKTYNMCHFWSNFEIADMDFWRSDAYQTFFEFLDAKGGFYYERWGDAPVHSIAAALFLPKHRLHFFQDIGYQHASYQHCPSSDESLGNSCSCHRWNTIGKFLYLCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHR8</accession>
    <name>A0AA38JHR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_863122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHR8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="337" mass="37326" checksum="507B7B23BB5B46E8" modified="2024-01-24" version="1">MARDRLAALRAQQQGGASQMSSNSYPTQASEGGGGGYQPRRANPYAQQDGAYEMADVKDSTANLSGGSDDMSSFYAEISSLQDSIRTFNENVTRIGELHSRSLNNTDDVASQRNAAQLDELVADTSALSATLKRRIKALERQAGSGRDGQIRKQQTALVKSKFVEAIQSYQNVEQQYRTRYKQRMERQFKIVKPDASPEEVKAVVNDDSGGQIFSQALLNSNRYGESRAAYREVQERHEDIKRIEKTLGELAQLFNDMSVLVEQQDETIQNIETTAATVEKDTEAGLNYTEKAVVSARAARKKRWICFIITLIILAIIGIVVGIEVARNVNNNKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JII6</accession>
    <name>A0AA38JII6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1080460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JII6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="335" mass="35726" checksum="4EFB744347784F05" modified="2024-01-24" version="1">MASIFASSSSAASSSDTVSTEEPWPQAGPLPVKRGEIGFRDDLVKGEADEGDSSSPLPERHPADRDSPSSSNPAPANAPVSASTSSPASPSSISDDSSLKKPKGLLSFLNRKKFGGIQLGTLIVFAIQVFIILGTIGAWTVAGIFLSGSAQSSSNNGPSMSAASATIFVHVIFAVAFLSQCLFLERRIYVMRAQRYAFLHPGEILPFSRRGQAVDASVAFSPWNRPPLPTYAAALAQSGVGTGDVEDHLIAAPPPPAYGNTRGSTLLLSGFLNASLRAQRPVSVRTEMSQQRQDRPASYVSNDEEWEVIQNADRARRLEETLTTLERPGSRNLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIN7</accession>
    <name>A0AA38JIN7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_999382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIN7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="510" mass="55908" checksum="3616C3456C3E3F5B" modified="2024-01-24" version="1">MANSDLDPESGRSSPILTSLNSSSALILVHDDEEETLDADYVQEPEDTDDDDDSPYLGITRPYVQPLSPTTVLLYLLAPYLKLGAMLLPNADLPLKLSIPLLLAFAVLAAFARQIWYLLSRYLQKGPGEEDVLVDAFSISRGSRITRQRIRGTIRSGTRAVTGISRLFLATTYLRASHTLLLSLPSDIYISNWAFTLILALFIYPFVIAQSLGSKRIIYSTWISIASYVLWLFCVIYAHANGAPTGHSSWLRMGSLWEGVTTIAFTFTSSSTLTLYASLKASAHAAKSAATKTPLSRSFKILSIVSVALAVCLTFPSLIFAASPNKPQSQDTPSYRLGPFILALSAITLLLGIPLVLTTTPSLPIPERLRRRTTIPLSKTIIFIIVVALSLVPMNVFRVYSDMLIICALAGTYFLPALVHITTHFFKRPLSIIVPALPLPPLPDSSFSLVSPTSTTPNSANDPLLQRKELMLRRKQFGRRIIWDIGVWTLLLPVGGGGFLWAAARIAGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIV3</accession>
    <name>A0AA38JIV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1140274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="608" mass="67092" checksum="B37D9F8184BC350B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ55</accession>
    <name>A0AA38JJ55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1145714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ55"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="175" mass="20455" checksum="5BFEC6C7E05DD277" modified="2024-01-24" version="1">MRIEKCYFCSTNVYPGHGSAFVRNDSKVFRFCTSKCHKNFKMKRNPRKVRWTKAFRKAAGKEMTIDATIDFEKRRNVPVRYDRELMQTTIKAMKRVGEIKQKREHAFWKNRMAMSREKQRAHRKKAIEAAKASSTKLVKPMTAESSSKREKIKVLAKSRSALVQGEGRSMTMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJE8</accession>
    <name>A0AA38JJE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mnn4-regulates the mannosylphosphorylation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_223594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJE8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40624" checksum="019E08E457F04C6D" modified="2024-01-24" version="1">MISILSRFTRGPTKAAFARASLIRPATMHTPTSIATLSTLSSSLNHPSANPRSLTQYQALRRSILVRTVASTVSNRPASQTFDHAAVNIREEASNSAADIAKTIAGGNISASDHSFVAITSSLASSVPKPVLAFGLLGTVPYVGAGATTVYLASVAGAAAAGHPTSIDPGVALTMLDQALNIQVTYGAVMLSFLGALHWGMEFAKPRPVQSESIRRLLLGAAPIFFAWPTLALQPMTALLVQWVGFTGLWWADATVSGMGWTPAWYSQYRFYLSILVGTCIIGSLAGTSYYGPVAGHGFLSHDLELTREMRKNLKDEREGTVSGVVEALPADQSSGAYVMLKKRDLTKEKQEQQEKQRQQAAKQEAEEIKKSQNDAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJM2</accession>
    <name>A0AA38JJM2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1036344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJM2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3736539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="508" mass="57453" checksum="6E009728BDD0FC78" modified="2024-01-24" version="1">MVSPLVILIASLGVAALALVLSLRIRRNRLDTAKLSYPPGPKVAAMPILDAWVEYRDWGNIYGDLIYLPEWNTLITNNAEVAVDLLEKRARIYSDRSMTPIMKLCGGENLLSVECYSEKWRRDRRVFQQTFRQAAVSQFYPSQYNKVHEFLRNLVSAPDSFLEHIQRLSQGLVFKSLYGLEIGPEDPLAKKAISIVGTFARALLSGGFPTYELFPWLIYLPSWFPGCEFKRVAAQCGKIVEEVDTVPFNIAMNNLKDGICTSPIAELAVQKPEDLQEIKAMGTMSFIAASDTTMSSISSFLLAMCMHPDVQAKAQEEIDRVIGRDRLPTFEDRRSLPYVEAVYREVMRLDPPIPLGFPHVSTEDDFYRGYYIPKGRFALWISFGCSVVANIWAINRDPNVYSEPDKFMPERYTNSPMGPFENIDNIYAYGFGRRVCAGRYMADNTVWLTVASVLAAFTLEKTKDENGNEIPITGEMTDLFFRHPRPYKSSITPRSHLAGELVLATADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJN9</accession>
    <name>A0AA38JJN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1146003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJN9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="162"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="274" mass="31732" checksum="943B680E2C34C02C" modified="2024-01-24" version="1">MKDEEILELRTKAPKLHKDYNVRMLTPGTVAKASQDMDEDMSDASEANALNLVFAKTTIPVPRVRRVIKREWGYLIVSDYIKGPLLADVWCTYSIWKKVCVAFTLRCYVRQLRQLKASPTTPPGPIGADGPRQCISPIFGQVQPFRGPFSSYAELTTFFNKRAKMGYDADNLPEDHPSRKQRFDDSEALVFSHQDINPRNIIAGEDGRLWMIDWGWAGYYPPWFEYVAMQRQLQNEEVMGSHHKYWDLLIPFVCGPYSEQHKWLDFMSMGLYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK38</accession>
    <name>A0AA38JK38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_333253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK38"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="163"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="403" mass="44704" checksum="264BFC530E5D5502" modified="2024-01-24" version="1">MASLVQRLYRIFVPPEPPKVKAEVEGSSNQPIKFGILGAANIAPPALIIPAKSHSEVIVYAVAARDLQKAQKFAKKHGISKVYGGSDGYQQLLDDPEIDAIYNPLPNGLHFEWTMKALLAGKHVLCEKPFANTAEEVRQLFDLAEKKELVLLEAFHYRFHPAIQRVKSILDSGELGKIKSVDAKLTAPAGAIKPSDIRFDLALGGGSMMDMGCYTMNCIRYLTSSNPTSVVSATALPLKSANVNETKIDRAMTATLALPNDVIASLEVDLAMPWEFFPPKLFKVWVEIKCEGGEVELLNFVLPTLYHSIKVSNKAGGTTTKRVEKIYKFADAHLDDPSKALGEDWWLTYRYQLEAFVDKLKGRTPQTWVTREDSIANLQWIENVYEKAGLGSRPKSNYVLPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKA9</accession>
    <name>A0AA38JKA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_993883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="349" mass="39332" checksum="0D205E5354C6A286" modified="2024-01-24" version="1">MSNPQLFPGENSTDPTVLDVEGYALCVFSAEGQNPDMQGYAVRLSNFIVNVCLALLIRYSEEDVAESVSVLLLQVYTLLVCAFVSLIRKQLSIADAHFALTSTVSPLALYLLYASVRKALRKSSYLFRRLDDHGTYSTLSLLMIPMWIIMNLLIYFTDLFSNTCPPITFASWMLFEGGAKAQHWKRFTWLQWLPLALKSFILAQWDVITKSHPWILTLSICTTYVIWGSSLILYVTDLGEFYYDLISGIQSENGIAVSPYTPPPGYDPLGYGQVKYSIHSIDFATNYESKVARRRCCLPTSLASLGHDLGKPEETASLDQRISRFTLEWYCVHFHRSSKSLGKGACKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL61</accession>
    <name>A0AA38JL61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1155486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL61"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41448" checksum="13E363B0551D4F5C" modified="2024-01-24" version="1">MDFMVAVVSAAVPALLASYYYYPRWKDSRIRAQLPLDIETWRYPGRSHEAEERIWNVLSPILARHGLASWPWGGASSTKTPDDEYPRPNGYNELFDQSQSKKLANLKRWLYWNPLNRAIRTKEGQDVVCRVIVVKGEGINALKSVRRISTGLNSLASCNHTLPMLREFTFKDIVFGIFPMSGSSFGMIFGPNSHDWCKASALAFIHEKRVAHRDAFIHNYLVQWDPESLKHQLVRLTRPRLYLIDFETALCFPEDSLYDDCTCTGLPFGDINDYALPTPPGVAEGKSYNAFYLDFWQLCYHLAFLQTGIPELDELLLGLVDMGTAAAALDALSERLGQIPPVQLHTRPMYREVVNGHTFYPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLN4</accession>
    <name>A0AA38JLN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1072166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLN4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3732670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="223" mass="24806" checksum="01263FD527FC1AC1" modified="2024-01-24" version="1">MSLIHALVAQGSTILAEHKGGSRDFSQATQTILSKIPPNNSKLTYVWEQYLFHYISEGGFTYLVMADDSAGRRMPFAFLSELQRKFLEAPSSSSLNDPELPAYGFQGTFASTIANLMNTYNTAPPVDEIARAQAELNQVKDIMVQNVEQILSRGERIELLVDKTDVMAGQAAAFRRGARSVRRQMWWRNKKILCLSILVALVLVWILLAQFCGAGLRCGSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM19</accession>
    <name>A0AA38JM19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1138726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM19"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="139"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="430" mass="47944" checksum="AC74049B8D2020FA" modified="2024-01-24" version="1">MDIFDDDNDVEVISRPSTSTPAASSTSSQPLFLPDHDEDEDLNEKENEKVPPAQQEVEDIFNSVVGDDLNFDYVPLARNQETDYDNFEREAQKKAKVKVPRHQILSSSPPPPDIDDDAKTKKGKRNDDGEKERRKPMRLDEARLVGPTGFPQLIEDTKHFKIKGKGHEATDLNRLLQIYQYWTHRMYPKSQFKDTVDRVEKLCHSKLMHNKLSMWRDEAHGKAHPETEDEVVDDNADDGSITHNIPKEVGVRSSVAPESDAAAYASSSSPPTRPPSSAAPSNAGDGLDDQDMEELWKEMEKEQANEARQATAPTRNSANGNENGNTQSFPKGGVDFMDVDDDIEGWLALEETMDSRSLTSTAASTGLSTSSKGASNTVAVAVDNDDEMWEMRHEIETENAKKQAGSKETSSEVPSRLVSTTEEDFDDMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPP8</accession>
    <name>A0AA38JPP8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_198007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPP8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="356" mass="39260" checksum="F5809AF0D8B38C1E" modified="2024-01-24" version="1">MSPSLSQPKAYFVSLFCEAIFAGLYTFLFCAAMYLLLHRRKRHPNGAKNVMIVMTVIMYCLSMLHLAFSLKINLVALFDQEASTPTDSIPKSAENTENVFACTPIAAEALNCILGDSIVIWRTWTLWNSSWKVIYLPCILLLGGLVAAGFLVHAMFISLVGQSLFNPQTIGAIVAFGVLTSMINFYAIVLIGYRAWTHTQHMKVFSGSESLASGFGGHYLSIFLIFVESGFIYCTVPVLMMILFGVSNNGVYVVIGILAQMTGIYPTAIIVLVCLQLTQHDTIAQAEFAISTGSHQLQRMDPEYTLTIPESVSSASSTSFVPQAIRVHTVKDSMDDSMDNFRSSPKRMEFEKDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPU2</accession>
    <name>A0AA38JPU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_162499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPU2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="846" mass="93038" checksum="29EAFD2CACF1F149" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPY1</accession>
    <name>A0AA38JPY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_697506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPY1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="40347" checksum="C01D3F103C6F8C0E" modified="2024-01-24" version="1">MWQSSRSLHFSRAHTSFASPVLTLRRITLGGLPTHFLMPTEHDSFGCNNNRRIQSLVQLCQRVAGNHIESISSVGELPFTLVQPILERCSAEQLLRLEDASPHLKNDTEELWRSLCRRTYSAMMERLEDGTDAVPDSWRTHFFILREAEARRLEEVGFRIRSQRLEADERKKEREVKFTERLPPPKRQRTGWNMPTQPRSLFQKTRSEASRLQKNMYNTRMIPPMLKGKDYRPTGSIASPPLLAQTSYSNRVTVKTVTRRPSSTAAGSSEPDTLPSKTPSPLKPTTSTSSTWKAETRSLLSSSNGTLTIPKKDTPKNAQISSSEKVASPSKSFPVAKRDPMASLFVPKHRAYSQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ22</accession>
    <name>A0AA38JQ22_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1053909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ22"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="148" mass="17150" checksum="FDEC3888DB933FB4" modified="2024-01-24" version="1">MPKIRTTRTKQPPEGYEEIESILDDYARKMRDAENESHEGKRKAESLWPIMQISHARSRYVYELYYKREAISKPLYDWLLKEGFADANLIAKWKKPGYEKLCCLRCIQTKDMNYQGSTCICRVPKAQVRSGTVVNCVHCGCRGCSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQY4</accession>
    <name>A0AA38JQY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1049040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQY4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3737052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="111" mass="12849" checksum="0837CB48C95953E5" modified="2024-01-24" version="1">MSQYALVPKSELDEAQLRQLEEHEISQGPLSVLQQAVRNHAQVLISLRNDKKLLARVKAFDRHCNMVLENVKEMWTEIPKGKNKKPVNKDRFISKMFLRGDSVILVLRNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR11</accession>
    <name>A0AA38JR11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_988389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR11"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="103"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="271"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="448"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="575" mass="63916" checksum="6A6516EBE21AC679" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRY2</accession>
    <name>A0AA38JRY2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_993419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRY2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22538" checksum="A1CD33A50AD04D5D" modified="2024-01-24" version="1">MPGSTSIFDVNKQLTFYGAYHNNKINILIHVICVPLIMWSAMVLLASAPRPSFLPEYHREFNKGMVLELNYPTLLLVVYETYYLILEPVAALLYAPQFILSLLTATAFAQRADHLTVAIAMQTCSWIAQFLGHGVAEKRAPALLDNLIGAIVLAPFFVHLEILFAIGYRPDMHKRLVNDIGTEIARIKKIEGDKRRAKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT21</accession>
    <name>A0AA38JT21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1073371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT21"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="176" mass="18337" checksum="CC65ED0733DD63AB" modified="2024-01-24" version="1">MKCTVGFSILAVFATAAFGNIIPRDFTTLQNDVQIVTKYCFVLKNTIEQVKAPLSSTILLNLIADSNNLSAALNVFASDAKIAGVITSAQALTLIASTGESIDDCINPALNVLISDAALLIAFKAEIEANLKKLQISYLSCANNLISACPSAQKAEASQVAAKPNAALAASLKAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT74</accession>
    <name>A0AA38JT74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_532135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT74"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="363" mass="38848" checksum="89EF1CA67867024A" modified="2024-01-24" version="1">MDTSLNLNTLASSLPSPYQNAEKDLLNNFKGFVVAAALSITTLYRSSRSASKRAYNSGYVSACNDLLLMIQQGVSAEGFEHTQSHDSSGSCSDAPSSQGKGMTIGKVMDWIEARMEAIKSREEEEDEEEERERERERASTANTAVPTAAANSSYKTLAGSKASTHIKLTREQPISNHASGLTIQSHSPSPPPTALRQSQRIQSKSSRMQPQNKGDSSVPSSPQVPSVDQSFLPNNTTFNLTSDNCAPFPSSPSPPLVSTLSPYSDHVPAVTAGAKRRHAVMMMLDSSSTSSSPASVGSSASTPSGSPSLMHGHHSVGSRRRTRSTRSSTHSLGLNINLGLAQEAMDVEEEGQGGRERKRVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JV44</accession>
    <name>A0AA38JV44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycopeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1150395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JV44"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041404722" description="Glycopeptide" evidence="1">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="15548" checksum="04AA77FB2493C4DA" modified="2024-01-24" version="1">MNLAALVAVALVAGAQAETHTVVFNNLCGRGVPVLKRNGATLSTGGPFTSNGPLVAAIAYLDIGCGADGEGCTMVETTLVNPTTPGSGSSTDITLIPPHSFSVTTGFGYFNGCDGAGADCTNANCPTAFHQPDDTHVQVACQVNNVNLAITFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JW89</accession>
    <name>A0AA38JW89_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_987156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JW89"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40284" checksum="8A18B6535001FD4E" modified="2024-01-24" version="1">MDQVIANLFALLRQLKPLPHVLQADLTGKVVVVTGANTGLGFEAAKHFAQMNPKKVILACRSEEKGEQAVQKIVRTGYMRAEVWPLDLSSFDSVQAFADRFEKEGGGRLDILVENAAVAPLESYQKTKDGYMTTVQVNALASSFHSLLMLPHMIRTAEEHPETSPRIVFVSSGLHESSTLSTDISKEILAQSNFIDALSSLEYFNQMWVFHNDPDPAVHTDNSSVLNIFFARALQTRLSKFCPIVVNSVDPGYCISDLRRSIVSGPRGWLFWLMDRLVAYSSEEGSRSLIHAALAGNKATIGASENETKYKGVYLSTQKIATVSKFARSEAGLRLQETFWNDMVQIASERDERVARFVKTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWH0</accession>
    <name>A0AA38JWH0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_147287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWH0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000002">
        <property type="entry name" value="Pre-mRNA processing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3734168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="349" mass="39805" checksum="D2BCF1A3EC4F425F" modified="2024-01-24" version="1">MDGLLAEVAAKRKAISDDQLNPKPSKYMRRGELELLREEQERKQKAETDAKKAAAVKQRKQEEISREASKAPSRPTSNSPLPEPREGASPIPESSFNISNEETIRRLRSKGQPIRLFAESDKDRRLRLRALELIEEKGHDRQAGQNDFKKALEDVESVERELKNKNSKGKKKGEEFAGEGVLDLGLIKTDPDKLYPIIYYALKRALNEWGEAMDERPEHVKRTTQGKLAAATQVQSAEYLKPLFKTLRSRSLPPDMLARMAEIVHHMQKRQYQRANDSYLRLSIGNAPWPIGVTMVGIHERSAREKISSDQVAHVLNDEVSRKYIQSLKRLLTFSQTKYPPEDVSQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXV9</accession>
    <name>A0AA38JXV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1045596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXV9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041230202" evidence="1">
        <location>
            <begin position="17"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="384"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="624" mass="69870" checksum="DA4DCAD14CDF47EC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZ10</accession>
    <name>A0AA38JZ10_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1045817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZ10"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="361" mass="39825" checksum="EBBE353F87F9B8E6" modified="2024-01-24" version="1">MRSFMHEIEVIIEEEIVPQSKEGTRLNDVKGKAKANNTPPTSPSFRGGASTTKSKSDNEPPTRADSTLSASSSTKLNPVAVPPSSDDQAHPLDLFNDNFNVEYASPTKKNTIKEQTSKAISQHVYDVDADEDESPPTPQPTSFMRKLKPKPADHLKRTSREWEELVPQSKHLEDKEDNLGRNHGSKPSPKRTASKADEEISVKKEKTSKPSSTSARSKDTQTGAGTDNHPTSISSQNPDTSPQNHIQSQTQTQMGTSADSEPRFKIKIWGPRNQNGEFMTRKKHIVRKVLAGACKNFGIDPSQAKLQQVFELDDEITGQVVSHYCDCDNDDTVGKAGIGPESTLRVYVEGEEDEIEEGHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K0T2</accession>
    <name>A0AA38K0T2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1050359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K0T2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="334"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="172"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="516" mass="58298" checksum="D8C081616D2D1A53" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K2B4</accession>
    <name>A0AA38K2B4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophobic surface binding protein A-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1035256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K2B4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041389223" evidence="1">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="184" mass="19286" checksum="E663C459FE20E47D" modified="2024-01-24" version="1">MVRFQFFSSLTLTSALLIPLLPAASIPVKRTLAKIESDITRVDALISTWDNSVNAFKGTLTQANAIHSAAIQLVAALNQATADTKATSPLTTDMDALVLLSQIENSSPTLVGGLTQIADKTQSFAEIRGGTSVVEQDVRTLQSSTAALLSAIAAITPAEVVPQATQFAITLNDAYSDALTNLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRB3</accession>
    <name>A0AA38MRB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1006205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRB3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="193" mass="21769" checksum="51ACA92EBEEA2680" modified="2024-01-24" version="1">MFLSIPIRRPTVFKFQRWLSSTPWFVEREEHIENPHASLASRAVPVPEDAPKILQDLHSQLIQSPHLEQSKLLVSRATSRELGPLPPLRAPQGRRRRGGTFPGESAFDIPGSLWNWTVFAEVKEGTEDKGAIEAVVRLVRKSLLAAQPPLPLPPNSKRRMQNGWALIDGGDFAVHVLSKVVRERYFSGSTTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MST2</accession>
    <name>A0AA38MST2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1000476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MST2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3730021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="318" mass="35272" checksum="3B4B06BBCA61134E" modified="2024-01-24" version="1" fragment="single">DYALTFPMEVEYLWTTKFRLSTFLYILCRYALLANTLYLVDIAGKLTENCNTWYQFIGALSVLGRAAVIVVFTGRTWAVWGKNRIVLVYMSILGATCVALDITHVPGLRCTGGSSIPITVSASDLLSILMVVFEYSSAILNSIRCIQAFKAHGKSMKEQKEGFQYLLFEQGSIVSLFTTAAVILNFSGFFQRLLNAFTLPLSGLLTARLLLHLRQWEYMHSQAAMTIHNGGQDQFGTEFSFRAASVVISTMITSDFGSDPVARGPNRKNARGDDFTPFSPSHISTRPDIESQSTPELVKSEGSTESVKEGKKPVRVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSY4</accession>
    <name>A0AA38MSY4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_999880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSY4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="287" mass="32566" checksum="92C7FE747B332770" modified="2024-01-24" version="1">MASVAFAPLTPLRYALKFALISFLCDVWTQICDRFKIKSTGIRWRLSSFIELRRAFFAHLWRVFGRGSDQHIHNYKQALLSPAQGVVLDLGAGLGGTASYLSRDKVFCYIAVEPNIHMHSELRDAAHEAGFHESDGTFVLLSCGAEDVRAISDCASTVNTPTNTQGSVDSIICILTLCSIPNAERIVTQLVKEVLRPGGTLFMFEHVRHPIISVAWWQWLWSPLWSVFFDGCRLDCVTDQWVEEMRDIEESGRNIAMWKERELKSDKGDGWEDNIIYHVIGTFVKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTY0</accession>
    <name>A0AA38MTY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1075080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTY0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="451" mass="52356" checksum="0E04A79E5D522C22" modified="2024-01-24" version="1" fragment="single">MSSRASKGTLSDPDQYGRTWLQLDDICKVRLSATETRKYREWRESIARNSQNTTSTAQSTIEDPTDSFFRTLNTSPPTSIDGSDFSAPIVQRKLSRKICQERIQLFEDQYVLDRAPPRLRVGQLDEPDSSGWRWYQCTEDVRVLLPPDAGVQYSTFSMLEEAHLRNATTSKTVAKFNKARMQFNELCIQAKCKHPVRGITSSQRRYALPVGFRCHSIDKLVGRAQDDCMLLIPEEIPTSTEMLSQPDEYWRRWLYMENETRILLPADIAAQLIFLRRNGVSHASHPLMRHISADFQCLSSEIITEQLLHYRHTGQNLFMLDPESRSQTLDEAVAHIEVNICRSTRKQIKHTTLKPQWHAVVRELEEYIDFPPSRDSSRDEQDVLYQPEWSPGVRRVAKRRRGVINLKAPNMDKELPPLPPESLSEQYSSTMDKRTLHDGQKERLWIRRKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTY9</accession>
    <name>A0AA38MTY9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_88502</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000117">
        <property type="protein sequence ID" value="KAJ3711625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTY9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041367039" evidence="14">
        <location>
            <begin position="21"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3711625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="303" mass="34445" checksum="0E3274B6E8C105EE" modified="2024-01-24" version="1">MLNTVFVALAILFTLQVFKALHLRSRLPPGPSGLPILGNLLQLPTSQTWLTFDKWSKQYGPIFYLNIAGQNTIVLGTHKAAADLLDRRANIYSDRPEFVVLNLLTGGMHWAWTHADDLWKRQRRGAHEALSAQTAKEYFAYQETESIIMVDQLLTDPKNFLAHFQRVSTSLSLSIIYGWAPVLDSDHPTIQQIDHFNRHLLVSAVPGSFWVEFEYFKWMKYLPKWMCSWRQDAEKRYSRDSVILEGLSANVQKQIDAGDEITSVAGKLLQNTGSLFEAAWNSTSIYSAGSETVSLMAHDYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU56</accession>
    <name>A0AA38MU56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1228590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000133">
        <property type="protein sequence ID" value="KAJ3710760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU56"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="8"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="306"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="566"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="833"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="952"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3710760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119421" checksum="2F051FA0A08FAD3F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUJ4</accession>
    <name>A0AA38MUJ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1142608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000118">
        <property type="protein sequence ID" value="KAJ3711455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1464" mass="165957" checksum="8CE0FB4F27EFC9C4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUL2</accession>
    <name>A0AA38MUL2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1008473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000107">
        <property type="protein sequence ID" value="KAJ3712551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUL2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23422">
        <property type="entry name" value="beta-trefoil_Ricin_MPL_CNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="244" mass="26830" checksum="2DF6F95EC9C4174E" modified="2024-01-24" version="1">MLFMKLTSCLASLFALTACTVAVVLPSRSELESRVYPRATEPIQSGLVFTIHNVKADTVVDLSAGDNKTITGWSLNGGKNQQWTTIWTGESWNFQSVETGLYLGFTGTAGNGTNLTVASTPTAWDIWHDTVNETNYRIFAPNTTVNWDLWGYGDGVSGDPITLWGAWSGIHQTWRFVQSMHRSTCSCYTISSNDVSSALFFLLSYLYFPRIYSSHLNTAVIISFPLSSSSSRLTGLAEHGVITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUT2</accession>
    <name>A0AA38MUT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1106353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000109">
        <property type="protein sequence ID" value="KAJ3712353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUT2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041241676" evidence="1">
        <location>
            <begin position="29"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="194" mass="20846" checksum="DF7B50158F706057" modified="2024-01-24" version="1">MFFSRRLFGKICAAFGASVLAFHHGAHAILPSGVSIPTPTFEPVYDATLLLVPNVSQDLVAGPFGERAFIGFLGGNLTDYATGALEGQIIAGFGGEFGIVSSNGMFYTDVALAVQWTDDDKYGFFRVQGIGELGNSTYATSYTRLETDSTTRQNLVDDVLLISIAVDTENASSNETIAYFRLFMKNSTNPSITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUW0</accession>
    <name>A0AA38MUW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1066367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="5">
        <location>
            <begin position="1208"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="867"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3733709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1399" mass="154313" checksum="885098E61F102111" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV40</accession>
    <name>A0AA38MV40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1160287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000081">
        <property type="protein sequence ID" value="KAJ3715973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV40"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="200" mass="22312" checksum="040852854597EB6F" modified="2024-01-24" version="1">MSFGSDPQDFVQYALSLPDNISDDSSHESESFEPYTDSNSGIDSDASDMESNASNDASDTSEVASWDEIIRRADPRYRHRFLRHMMDYYTNPDPDVGPFDYSDSEFNYSHDSLVNSAHSSDSFHSAHSSIAGSESGESSHDNGSESSPEPPDYMGPDGRLLESERERRRNLSLCFYCGGDHFRSHCLKLRAKYSGDSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVI2</accession>
    <name>A0AA38MVI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1165545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000103">
        <property type="protein sequence ID" value="KAJ3712988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVI2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="169" mass="18340" checksum="CDF741FD68A58E32" modified="2024-01-24" version="1" fragment="single">SSNQHQLALAYWSISISFNVLVTILICWRLLAMRRKLAKSMAQKESISPYTTVSAMLIESASLYSITGLAFLISYGVNSPVQNLWLPLLGQVQSIAPLLIILRVAEGKAWSAETGNSIVSTTINFASDNVISSKSFTPRSRTINDTSSTRSMGSDILAGEISGIPMKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVN0</accession>
    <name>A0AA38MVN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_796314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVN0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="100" mass="11160" checksum="FB111104E92F8CC7" modified="2024-01-24" version="1">MLHPEFLAFAKAMWRSKVLWTIMLFERAMAGTYLRSMADQPISTMAVLGILTAKEAPVRLASSGAQFITITLPSKRRNVPGSRTSMIRQSTKTKTTRVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVS0</accession>
    <name>A0AA38MVS0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-xylanase</fullName>
            <ecNumber evidence="13">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1062074</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVS0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041307033" description="Beta-xylanase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="16">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="17">
        <location>
            <begin position="81"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3734894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="398" mass="42231" checksum="89963708EF674446" modified="2024-01-24" version="1">MIHITSSFVSLLAFVSIAAAQSAVWGQCGGIGWTGPTTCVAGSTCVESNAYYSQCLPSTSTSSGTGSTGTSTAALPTSTSTAKSNTVAQAAGKKYFGSATDNPEFTDAAYLAILSDNTYFGQITPGNSMKWDATEPEQGTFTFSGGDAVVSLAQGNSQLVRGHNCVWYNQLPSWVTSGSWTNATLTAAVQNHCSTLVSHYKGDIYSWDIINEPFNDDGTWRSDVFYNTMGTYFVDVALIAARAADPNAKLYINDYNIEGTGAKATAMMNLVSNLKSRGIPIDGIGLQGHFIVGEVPTTIQTVMEQFVALGVEVAITELDIRMTLPETDALLEQQKTDYQNVITACNAVAGCVGVTIWDYTDKYSWVPSTFSGQGAACPWDANLIKKPAYDGIIAGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW29</accession>
    <name>A0AA38MW29_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1037222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW29"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="224" mass="24695" checksum="74E31AD09153B957" modified="2024-01-24" version="1">MQLYTSAGIGYKTCLIVILGTFSFVFPALIPSLSSSSPPPVDGSPARRNGAYPHVWVKLSFKDRPSNGGMEQEKNEEFAAATRAVQAFLNRAAPDLGFSMLTIDKPVQGYPVADERGNLHFTMSIVPTYEESEVRYEGLINISSSAINGQLSRSDKVVVKVVDDKVKEDIPARTQNGNGKNVKFHVHPDRVTYRPDDPPKELLSPPRRPSLTSLKSWTGWLLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW90</accession>
    <name>A0AA38MW90_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1005607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW90"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041324501" evidence="2">
        <location>
            <begin position="27"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3719046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="653" mass="67597" checksum="9E9F38B39B6BC4F7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWC8</accession>
    <name>A0AA38MWC8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1099171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWC8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="131" mass="14361" checksum="DB22E3595A0686C4" modified="2024-01-24" version="1">MSTNLDASHNEHDAPAGNLVGANQAGSSEPSAAPLNTQEATNESTLGDISPLLPKISPDNDFSLDLHSIISAGDPEMDKVNKRASNVQKLAQENEKLKEELRAMSQRLEAAERRRQELDRKKRNMKEPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWG8</accession>
    <name>A0AA38MWG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1207157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWG8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="530" mass="57060" checksum="9E2F05B99F270503" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWT8</accession>
    <name>A0AA38MWT8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1093891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWT8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="265" mass="29564" checksum="58C244DC5B0FFE16" modified="2024-01-24" version="1">MVSSADVKDSDRNIPVPPSRSLNSHSSTATHNKPTKNDWFIQKVLASDTSTQLGRTSSPSLADMLARNPLPAPNEERFKPPVFLAIGPSNKGFTMLQNSGWNEGEALGQDVVRRQRIQQNDPSPWVKEEIVEVQIGDGDITEIKKIPLIDLTASDSEPEPRSEDEGDIDISVDRQETGRKALLTPLPTVLKSDRLGIGLKAKTAGPYKESVKRVTHNAAALAAHHQRVEEARMRKEKWGRGRRGFARRDKEEQINRRNMISYMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX32</accession>
    <name>A0AA38MX32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1091671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX32"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3723586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="242" mass="26834" checksum="CE77EB94656FC275" modified="2024-01-24" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTTVGVRTDEGVILGVEKRVQSPLIESSSIEKIMEIDAHLGCAMSGLTADARTMIDHARVTAQNHSFTYDERIKVESVTQAVCDLALRFGESVHDEDAMMSRPFGVALLIAGIDELGPQLYHTDPSGTFVRYQAKAIGSGSEAAQAELQDKWHSKMTLQEAQTLTLRILKQVMEEKLDRHNVQLAQVTKAKGFEILDETSLKAIIDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXV6</accession>
    <name>A0AA38MXV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1085600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXV6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="208" mass="24306" checksum="0371F44EC2200797" modified="2024-01-24" version="1">MASTSTSVMARSESKPYQPSLKGTGDEYQTLYCSLCDVYLYSKNLLRQHMEASSRHPRCDSCHKRFLNLNSLRRHYLLSNRHNYCASCDKSFATPLALKIHFEYATFHRDARNEDEDALYVEQRRHKGWENRVAADIERRENVEDDVVVPERDALSRIEVTKKILQLKQRMSDRQHLSPKILKQTCAICLCVPKKMCVTRCGHMFCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY20</accession>
    <name>A0AA38MY20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_533513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="807" mass="87884" checksum="AF0666F20BBB3B63" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY49</accession>
    <name>A0AA38MY49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High-temperature-induced dauer-formation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1092025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY49"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3723483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="914" mass="101980" checksum="72BAA6E0C488943D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY61</accession>
    <name>A0AA38MY61_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1122817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY61"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3726366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="705" mass="79367" checksum="D636772D55156F62" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY78</accession>
    <name>A0AA38MY78_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_569288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY78"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="2">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="276" mass="30093" checksum="DD79A320B78EA7BA" modified="2024-01-24" version="1">MESTVHLKHVFRQKDSTLISALNALRLGAPSNEAIELFNSLSRPLPPSPILPTELYPLRAQVAQSNASRLNALPSPKVPYVARDSGTKPKLLENMLAEERLELKIDAQVMLIKNVDEVLVNGVVGRVLGFYFPSQLSGGTPPASSASGLKSGSAAVLSASTSNKISTSTSSIKSPTETKKNGALLRYVQLMDDGRTPVNASHPRNKENNFGVKLEVKPNKKQKESKEGEESEKYPLVLFEYPLQDGGYGSEAVLIKRDEFRAEDAEGKLLARRIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYX4</accession>
    <name>A0AA38MYX4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_999784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYX4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001070">
        <property type="entry name" value="Dynein intermediate chain, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="487"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="667" mass="73598" checksum="2CF846A174826E94" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZS0</accession>
    <name>A0AA38MZS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3732016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZS0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="229" mass="25125" checksum="59A28F80DB20A3C1" modified="2024-01-24" version="1">MYTTICYGTTARGLDLNNSDSEDNDNDDENQHEEGDEGVPALKSGKAPTEEGSSDSEDSDTNDENQHSGEEDEGVRTSKSGKPCPKQDRRKGGSGSHVRQIAPLRTTKALDARIHASETRGGEGRASGLSAEEERVLRIALTKLNQSAEGEEGEGEQRVGRNQSRKRRHSSDSEVDSGFDDAHRRHALDQLDRLSNGGGTEKERWERQSNGKGKGAGRELQRCRGRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZU2</accession>
    <name>A0AA38MZU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_997861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZU2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041270321" evidence="7">
        <location>
            <begin position="23"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="8">
        <location>
            <begin position="11"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="459" mass="49893" checksum="125657E46B3FDC9C" modified="2024-01-24" version="1">MAGISSNITFILLCSLWYMTSALSSNTGKAILNEFRYPITLTFVQFGFVAFYCLLFMSPVLRFSKLRAPTRSILRDTLPMGLFQVGGHVCSSMAISRIPVSTVHTIKALSPLFTVAAYALLFGVSYSAKTYTSLLPLTLGVMLACSSEFSLSNAVGLLCAFGSAIVFVSSNIFFKKIMPTNNGGALSQPSQKLDKINLLFYSSSMAFILMVPIWLYYDLPIFLSSSDHVSHPSHGHSNPHSVTYYFIMNGTVHFAQNIIAFVILSSTSPVTYSIASLMKRVAVICSAILWFNQSVHSIQAFGICLTFAGLYMYNNAKGDVEKGEKKMMRVEAARELKLPTTNADARMMSGIDTPPEAYSMPQNDTAMTSATGLGSGSIHGRPRAPSAVSHLNSHNLSVKITPPSFNTKKSPKDRTASPTDSYPSPPPSLDSPPSQPAHLSSQTGHFDLPEHSHRTTTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZY6</accession>
    <name>A0AA38MZY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1074042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZY6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="424" mass="47662" checksum="A884D655D4B4E7D5" modified="2024-01-24" version="1">MTPSKVRVAIIGGGIGGLTFAVALKECSDLQVDLYEQAHQITEIGAGITLWHRGYEILKSLGMKDDLVKLLNEESKDLDKQKLSFQYRFSDRKDGVEYFGLYSKGGARLFHRQEIQQMLLKHVPEFVTIHLSHQLERCEEGQDSVRLIFKDGFEATCDIVVAADGIKSVVRDSIPNDGVLPMGTNVFRGLIPREKLEKLYPDHSCLEHPTFLCGKSQYIVSFPISQGRTINVGACVTKLENEGKPLNGSGVRRSTTQEVLDLFVGWEDQAVQLIENMENPVCYALQELHPLKTYISRRIALVGDAAHGMTPYLAAGAGQAIEDAFILGRLFSEAGPENWARVFEAYNLARQPLGNKVQLDSRSQGFYLQLNAPEFENVRESRDLTHEQIEILRKSFTKHWSWLNGDVDQELTRASEFLNSAKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0G7</accession>
    <name>A0AA38N0G7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1118518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0G7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="243"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3732616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1222" mass="130720" checksum="66A7ED7B687B06DB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0Q6</accession>
    <name>A0AA38N0Q6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1070780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0Q6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027951">
        <property type="entry name" value="Nepro_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14780">
        <property type="entry name" value="NEPRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolus and neural progenitor protein-like N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="211" mass="24495" checksum="19A2D749E25CFB98" modified="2024-01-24" version="1">MNARRTSLTPSLTERGFLPKNCHATVDSVLKDLKLYSRRLSTTTTALAEETQILDRLHYKNKNQHRSSLFIRRLNELRRYSHRTEEFQICSFVNDLRQCFFGKADGSQQKQMKGAWSHHPDEEYVSKVKEQSSCFLSLLRKMHAVSSEVFRSLSLAMQTGAFIHLFLTLIAITSKIANLVAEMIEILQLVIPVMDRLLAIFKVRFSRRLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N132</accession>
    <name>A0AA38N132_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1068324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N132"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="770"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="867"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="949"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="788"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="949"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="973"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3733291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1252" mass="138491" checksum="511E8AF280069547" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N193</accession>
    <name>A0AA38N193_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1180625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N193"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="906"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="944" mass="103990" checksum="3626950BF05E27CA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2B5</accession>
    <name>A0AA38N2B5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1130621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2B5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="501" mass="56660" checksum="0090674D67579863" modified="2024-01-24" version="1">MECQTIALVASFGLSLFAFGFSASFSVYYTTLIFCTTAYRLSWWHPLAAYPGPLACKLSKLYMAYISQKEKQHLYLYNLHQKYGDIVRIGPNEVIIRSTDAITPFWDGRFPANGAGRSLISVRNNKEHAVRRRPWNCAFSSTAIKNYEPLIEARTNELVDTLGRQTGTVDLLKWMKYFSYDIMTDFVFGGGTHMMRDGDVDNIWHQIESSQKVSLFLSHVPWLGQMMFRIPNLAKSRKAIMAYAIQVAEARNLRPSTNKDLYYYLFNEAESALRPLTKQEALSDSLLAIGAGADTTAASVSNIFYFLLTNPSAYNRLRDEIDAYADHALNYNTQAGMPYLNAVINENLRLLPAVPSGSVRGTTQETGGQYLGSYYIPPNTTVSIHFYSMHRDPRNFSLPDLFLPERWLSMEERTVLEPALFAEPDSFIHNPSAFIPFSYGPASCVGKNYAYLEMRMVVCKILVSFDICRAKEFNSSVYEDSIKDLFTLAVGNLPVVLTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4I7</accession>
    <name>A0AA38N4I7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1049636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4I7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="261" mass="29050" checksum="406955ED57FB475B" modified="2024-01-24" version="1">MAAQISKKRKFVADGVFRAELNEFFTRELAEEGYSGCDVRVTHARTEIIIRATHTQEVLGEKGRRIRELTALVQKRFKFPENSLELYAEKVQYRGLSAIAQCESLRYKLLGGLAVRRACYGVLRFVMESNAKGCEVIVSGKIRAARAKSMKFTDGFMIHSGQPAVDFVDSAVRHVLLKQGVLGIKVKIMKGWDPEGNIGPRKPLPDSVQILEPPVDKIVSEPSSESREPAIPVAPPVQQEEAYAAPEAATYQAQQPEYEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4W6</accession>
    <name>A0AA38N4W6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1220983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4W6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="109128" checksum="E6581C5BA101AA77" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5B9</accession>
    <name>A0AA38N5B9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1149500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5B9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="133"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="446" mass="50378" checksum="EB4BA9414E47086F" modified="2024-01-24" version="1">MAPELPPDILQLRPGLPSPPRTPLWHDNPDIPYTLSTHIIDASPLRTFPQIKLLDEVSLPAYARMQTSNLDTKGRQKVAQEQVGLMLNWRREQEETRRSQRTSGHERRLWLCLNRYVKKDLDKAPRKTKGLTLIFAHALGVNKETWEPLIMRLVKSRAGRDVEEIWVWESVDTGDSALLNSGKLNQLPDWYDGAKDILHFLLHYMPSRITSDRLPVHLPRVSVAEFEERERLGFSERQIIAIGHSYGGNNCGRACYSYPQCFSALVLVDPGIVKLNDPTLRPTLRYMAQGSYARRDSWKSREEALALHKKSSFFGAWHPEALRMFIECGLYSPISSDSDSTVYLKTHPVLEALAYTNGVEASEDMYAKVPSLDQKVYIKWVMPDRKKGGGLAGPESSDRLVKLRPGNTSNVNIAGASHMIPLEKPDEVAREIADTIEIVGATSAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5D9</accession>
    <name>A0AA38N5D9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_402826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5D9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="505" mass="54708" checksum="2C0CF84B096E521C" modified="2024-01-24" version="1">MAATAVSSSSTLWATASKDWVIQPKPKPGRKPKKEVVVEPVEDPDGKGRRVQNRAAQRAFRERKQSQLSELQARIQLYEQGEIERNVALQNIAKRLKEENEVLRRENAVLKGKLDAAEQHLRVNNKGHWRDDSPTSSINCVAPTRKRQRLDDGVQDAILSHMTTTFSSASPPSMASSPGSNDTSDSPFSPIPLDNHLSHSSLLSLSTVDKYDNYGEHSVFMSCGFCSEHLPCVCREAFPSSTDMVPKTEVFETPAPGIIRIGSPAPHTTPSILDELPAYQPAVPLRRRQAAASAPVKPVVPVVAPTCSGDPRNCLACADDSFGKAFCDALGKSVAAQASSSSNSSENLSINPAEVSLSAGGSHQSISLQPEGESIPTNDAWEQLKSHPNIAFSDLALLADVVARRSKCSGPRVVISPAPGSITPERIASPDPPVNFTHEKTGDSEAVVLTDPHALFREQKKARSSPPRLVPQEVLMQRGQERLRQVQAAGVREALRLLDAKYTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5P9</accession>
    <name>A0AA38N5P9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5P9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="254" mass="29128" checksum="33D21340B384D491" modified="2024-01-24" version="1">MSLLRISRSDESKSPTSSLSEGVLSNTLPQLLEPHRMDITSETKIQKLHAGDSSPSPSRKRKRLNDSNASATEKVQLWQSRQDQVDVEESEQSLAGEQSPNKRIRSMAPPPASPKTIEYRQSTLGTPPSKDFRLSQKKVRVILRQLKDFPNARIRMKHQLMETEEILAVAETVHRKNEGMLTEMQWTRYIIEEDVLRRQKADRTLVDGTEKLGSASTQARDWRKWLQQNTMARHSNLNRTWSEKNGNASSKLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J155</accession>
    <name>A0AA38J155_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1173215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000154">
        <property type="protein sequence ID" value="KAJ3709875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J155"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="347" mass="36863" checksum="A8C292320F4D3A32" modified="2024-01-24" version="1">MYLRGSCSHKERREQPLIDSEGIVYEKTKSKPTLRVKVPPNPDSNPSVSSTSTSLTLSTAIDSPATVTSPTSATINITHGIFAISDSPPIPLILTTPSNTSHPSEVNEDKNSPRRKDKGNARASGVLLLNGDIEAESEVKSESGEEENDGGGEVEREDGDASSGNVWDGEVEAGVRWVAEEGEVFREGNVLLGPEEMEGEYDGEELRRELLEATVERPAPRSLHIDDPDEYGSILTPSPLSPTSTPISSTPLSAPLTPMIPPPASSLTPSSSLSAPPTTPLVSLPEHVVVTAHSGTTPTQDYSFTFRETPSLTSLSAVVELPAVRPYIPRTRSTSSTTANAVQNTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1K2</accession>
    <name>A0AA38J1K2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1107192</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="JANVFO010000115">
        <property type="protein sequence ID" value="KAJ3711826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1K2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3711826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="694" mass="77342" checksum="B1AA2967E983C3EF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1X3</accession>
    <name>A0AA38J1X3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000144">
        <property type="protein sequence ID" value="KAJ3710139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1X3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="267" mass="28892" checksum="D836C1D76BC9C5CC" modified="2024-01-24" version="1">MTPQSVRLNLSFGLEYALRSGKFGDAEGFLDTNILSCLDAARILYSDWTMLKGRKSTGVFRESRCLSADKMPLSNITNVRNKAQSSIKSCSRSADIPTLMKKRKRGPSPSGSRLALSLKRNSSAKRISSIKADADKNATSQSTGIMDEKEIQRLMKILGETVEHVDDSKVLTSTIEFQAQALHNVVSLDLESCFSNSPPMVYSAPSLSRCSSSSVTSSTIFSEFIGTSSSRCSSASSLSSSPTESTVNANNRVNNPSDGVRAISEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2F9</accession>
    <name>A0AA38J2F9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Prenylcysteine lyase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1127550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000093">
        <property type="protein sequence ID" value="KAJ3714001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2F9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="8">
        <location>
            <begin position="149"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3714001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="513" mass="57355" checksum="8891FF31F5C454EC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3W7</accession>
    <name>A0AA38J3W7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1159590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3W7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="277" mass="30893" checksum="0C0B22001AFE4C87" modified="2024-01-24" version="1">MNSSLIALDSFPTAVTLSEMPNPSPEEQEVLDRLNLYGVDPLFRVLKEDDLVPTGINPFTEEITVSLDGVVSACLWKALIDLVKLVFRAGNTAPGGVIRPEYLNVVGMTLPPSFSNIVRFHDSHNPLGYSIPRLQAEWNFYTAQRMLRELVNWISTCQYRCYKFAEAGIDPLWAWTQALTTGVVPPPDTFVFTFGSSYPGTTRTYDPRLPGFDPRLLEYVLPSQEVVLHPIASHYAQHYPGFNAFTRDVLVSVPDSCTGDVSCLGLFGDDLNKIQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4B2</accession>
    <name>A0AA38J4B2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1006962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000080">
        <property type="protein sequence ID" value="KAJ3716236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4B2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3716236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="153" mass="18213" checksum="1E6CFFBBD5106A63" modified="2024-01-24" version="1">MLRPLNSLLRRWHRMLGLQRQSPPSWYKDRLREELRERRSAKTSLHKLSETSDVFFAIIRANYDGFIVRKIPPFVASRHSLVYAYMLGKYTLRWGFYRTAAILCKAPRCDSVREVVNPGKDSKLHEVALRHQIDPEKFKRVGRKLRRVWPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4T1</accession>
    <name>A0AA38J4T1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1098322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4T1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129:SF1">
        <property type="entry name" value="ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="611" mass="68477" checksum="CC997CA809319DCD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4Z6</accession>
    <name>A0AA38J4Z6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000183">
        <property type="protein sequence ID" value="KAJ3709455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1307" mass="143342" checksum="428E1B4CF9E548C9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J574</accession>
    <name>A0AA38J574_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_981542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J574"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="180" mass="19808" checksum="355CDA632FF696A8" modified="2024-01-24" version="1" fragment="single">NNISISHPFGTINCVYTIDPTLKLFPSSSKRTRIQSNIKLRTNIGSINADLTLVSGVEENIRTLPTAIMDISSKMGSVDVKLRRSSTNVPTIRLYASSRTGSLSILIPTNFHGFIVAYMKIGRLMLAPSVQSCAVVVREEMKVKRIFIGDPGVLRDGRWKGDEIVLRTPVGSIEVGYVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5J5</accession>
    <name>A0AA38J5J5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_112159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000121">
        <property type="protein sequence ID" value="KAJ3711261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5J5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3711261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="459" mass="49407" checksum="4ABCA0C1DB35C289" modified="2024-01-24" version="1">MYPLYRFLRCSLRNAEWLELDFHLRMVVCNYFLRGQCRFGDKCRNEHPQSGNQSWVNSASGSNTGNKDSAGLFSQESLLSDITLGKEKPLWPLSSYGPAKYEPDIVVGLDTCPEELRVKAWEAKVQNNVNGYIQYEADKIAQADRSFNNARGNIQMLYDQAIQQSSVISSSLGAPSSAFPSSSSAFVSSSNGAFGSNNAFPSSSSAPSIFGSTSGSKPAFSSSTSSPAFASGNNGAFSSLVNKNPTTSAFGTPSTSNATSAFGQPSVLGANNSLPFGKPSSSVFGQPSALGATGSTFGQTPSTTNPTSAFGFPSTTTTSAFGQPSTFGSAPAASTTPAHLQGLPVVALVRSVPVSLFPLRLVQILEVSLPLLARSRLPSLLLALTPRQIQVGRYSVNRLQLEEAHLRALLGVILQHLRQRQHLHLVLWHLHLLHLHLERSVNLRQLRLLRHSDNLRHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5X5</accession>
    <name>A0AA38J5X5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1093703</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5X5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="66"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="404"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3722043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="599" mass="64340" checksum="D8CA346B02C21822" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J634</accession>
    <name>A0AA38J634_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J634"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="18282" checksum="8DA313A78384B7EE" modified="2024-01-24" version="1">MYNPVFTESSLFVCDGTDPTSDLFCQDATMGIVFVAIVTVFLLGVVVIIMALFEGVCFIAAQAYTYLAKYDLCDKENVLKRREQAVVLRELAVNRQERTLQMDVEIKVCERLTQILRRSSASAQERAHELEIEKELLSEIAGCGGDTSGDGSLIHRLTKSPIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J659</accession>
    <name>A0AA38J659_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1087561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J659"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="237"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="771" mass="84634" checksum="31D6F4FC979F2404" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J677</accession>
    <name>A0AA38J677_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J677"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041440064" evidence="1">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="22780" checksum="DB9B22FD6617BE82" modified="2024-01-24" version="1">MYIVNLCSALLVNLCCGTDCLSALLFRKHFHHSNLLKADFLSALPLNAGSPQLFLLDSPQDSVLMRSDQNGNAIHAGHEVGVNEIWALKVGGLEFRAVEEPKGSGTWKGLPVSVTSRANDGAITVGHATFSSLEVWQGVQNYLLSMTDSSNLEYIHHGLGYLQHGNYLDSNLLIWLQPNTGNGFVGLYHQMQALGGSAGGGPLTKKIIPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6D2</accession>
    <name>A0AA38J6D2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_57491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000109">
        <property type="protein sequence ID" value="KAJ3712354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6D2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3712354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="247" mass="28457" checksum="8CCA0758F3CA3CD2" modified="2024-01-24" version="1">MPVDIFLDYLINSTSSMPIHLDENILTELEDSWLWRHMTPHFSQNDDKDDFILNWTRETLAEPDVLGVTDAEFDEKLALAIKSETFLANVRAANRHHDPQSVLPNLSFGLEYALRSGKFGDAEGFLDTNILPCLDAARILFNDWIMLKERKSTSIFRESRCLSPDKTSMPLSNITNVRNKAQTSIKSCSRSADSPTLMKKRKRVPRPSGVFMSNYQSFSEHLHRFTFRALFEAEFRSKKNSVNQSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J702</accession>
    <name>A0AA38J702_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar complex-associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1172088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000143">
        <property type="protein sequence ID" value="KAJ3710234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J702"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="2">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3710234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="458" mass="52156" checksum="37FD4B020E250B22" modified="2024-01-24" version="1">MNEDEGSWDSEVSDDDESLDSFEDPGSMSDSAQDVAADLDSDVEMPYEVVPRKLREHSQTGMEGPERLPIKLKDESEGDSGDEMKNEKRSVRDDAATGARFGRLAIIDILENKSRKARIQIAKDQIASICQKILSDPENSCQQPHILNPFLTIPSSKNSRSCHNWLYDKDIIPGYRIRSLTDQEKSEKVSQAVARTREYEQGLVSIYQNYLRVMEVELKARNSLSETALQCICSLLTELLHFNFRINLMSCVVAQLSGKSWSELCLDTLIRVFRNDLTGTASLELVRLLNRMIKEKRFQKSKADKTDKGAQTRSKGKDAARRAKGISSDQPHLSKKPRKALKEKKEIVREFRDAEAVIDQEERASTHMENFEIAIRSLFRNSNPTPLLPAALEGIIKYAHLVNIDFFQDLMKVLRARVHMHWPTAVVVPTLQFVQGLVVKDPRLQLQALHDDLRDHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7I8</accession>
    <name>A0AA38J7I8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1134783</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000088">
        <property type="protein sequence ID" value="KAJ3714889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7I8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="38"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3714889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="201" mass="22948" checksum="3FCE7874D3A78594" modified="2024-01-24" version="1">MSYTSTGNASIDRLAFFHILEALKTQKRTGWVNNNISNPESISDHMYRMAILSMCTSDTKLDVAKCVMLSVVHDLAEAQVGDIAPSHGIPKEEKSRLESEAIHTFVHEMLHNSPAAQRIEALWKEYEDRETPEARFVKDLDRFEMATQALEYERALNESALQPFYDTSIPYIEHPEVQEWGKDLLEERQRLFGTGSSANSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7Q4</accession>
    <name>A0AA38J7Q4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1008979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000122">
        <property type="protein sequence ID" value="KAJ3711240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7Q4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="65"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3711240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="319" mass="36415" checksum="FB13A7316E275965" modified="2024-01-24" version="1">MQLLRNLPSANKLPVYQRPACLARQLPQLYSRCYASYAETPSDSVPVDLDFLEQIPENGNNTDGALVILHGLFGSKRNWSSLSKAFSRDLDTPVYALDLRNHGSSPHALPMTYTSMATDVLNFIRKKNLSKISLLGHSMGGKVAMALALNPSLPPSMLQNLIVADIAPVRTQLSPEFISYIKAMKRIENMRLRTRKEAQSVLTEYEKDPDVVLFLMTNILMPHSESNRENYIRFRVPLKYMEDAMPEIGSFPYVPNETKWDGRTLFIKGRRSKFINHHYHQIMEDFFPNMTIETLDAGHWGISFRPNEFMQLVKSFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7U6</accession>
    <name>A0AA38J7U6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1080259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7U6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34270" checksum="F9998F72B866C796" modified="2024-01-24" version="1">MKSLPNEVLDLVLQDVCVIDDDEFEFAHRFGSKPAFVTTRDAALLVCRNWNQIACMSFYHTIILSTAEQARCLARTLSSKPHLGVRVRKLLFNGGFGATASKIMKCTSNITHISLSLAVSSWDSTKGLCSSLRSIQPCSLSLNDFNNTYNNIQTRTLVAAICSCVTVHWSRLVKLRFPYETDWEWKEKTENQSLLLRAMYDTPLLKFVHMPAPYNPHLLLPLLSKPTLHAIYSETPFGFMRGHHIKGTCDGLPVLQLPHALCEKIRFPLPGPWVLSGRPYGILQAESNNSNLNLMFRIEPPHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J831</accession>
    <name>A0AA38J831_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1127275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000088">
        <property type="protein sequence ID" value="KAJ3714880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J831"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000002">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871:SF1">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3714880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="476" mass="53063" checksum="D524C0A0FFF209BA" modified="2024-01-24" version="1">MGRPTPSSSQNSLTVHDNRTGKSIEIVIEDNSIPATSFKALSAALEKGEREENETGKGLRVSDKGFLNTAVMRSEITYIDGDAGGVLHCCYPIEELALHSSHLETAYLLIYGSLPSSSQLKVWESEVMHHSVVHADAEQFFRSFRYDAHPMAILTSAFAYLGSYYSEANPSLQGQTLFTKGNPESLAVMDRQIYRLIGKATTLAAMAYRVRQGRSFVTPPTGLSYTGSFLYQMDHLGEENYKPNPILEKALDVLFLLHADHELNASATTVLQTASSLVDPYSAIARVSKVFFRSHLSGGANEAVIRMLISIGSPANVPAFIEAVKKREKVLSGFGHRVYKTSDPRSFIVRKTADEVFKVTGKDELLETAMALHEAAMKDEYFIKRKLAPNVDFWYVGLIYRAMGFPLDFFPVLFAVPRVVGWLAHWRQMMLQPGGVKIWRPRQIYVGASKREYVPVERRIPEEGSRKTPSQISHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8S3</accession>
    <name>A0AA38J8S3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1008464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000107">
        <property type="protein sequence ID" value="KAJ3712549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8S3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3712549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="84" mass="9648" checksum="A3869464B5D74005" modified="2024-01-24" version="1" fragment="single">IRILDSLGELHRCGLHHGDFAERNVLINDNDIRIIDFDQPVYHDCDSKTTFEFRSGVGQRIPDVTEFGCPALWEICRSDMAIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8U9</accession>
    <name>A0AA38J8U9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_777726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8U9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="157" mass="17492" checksum="A121CFD09D3A919D" modified="2024-01-24" version="1">MTTTNMREDKSPYAAAAHVPLIKSPSLRVPPRIELPEDIHPLPDSVTPYFVYPFTLEPHVLTLESSRRSTVSSHQARHEAFLLSRENEKEQRKREALRKIAPGFEPRGSVLVPTRATSVPLSATPNNVNADTLPSSTGHRYTKSVMEDLVDQLAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J922</accession>
    <name>A0AA38J922_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_142068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000138">
        <property type="protein sequence ID" value="KAJ3710509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J922"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="150" mass="16912" checksum="4EE53E8D8BFBCF40" modified="2024-01-24" version="1">MFSLCYLAILGWQMKRRLGSVCLTESSPSISILGCHLESIIPVLGHSHAYEVFAQFLEASNLLANKHRASFNFRRARSKQRGPNEGVWTIGQINLDLEAVELETYTTSARIAEGSFKKHRSSDCLSFLIGLSLPSSYFHFDSEVFPPRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAJ8</accession>
    <name>A0AA38JAJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1092245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAJ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3722772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71279" checksum="39BB825EEF542515" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAK5</accession>
    <name>A0AA38JAK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_270655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAK5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119">
        <property type="entry name" value="ABC TRANSPORT PROTEIN ATP-BINDING COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43119:SF1">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="254" mass="27704" checksum="E10D6DC3CD9AF98E" modified="2024-01-24" version="1">MDLLAVHDLGCTTEDGSQIFSGVELTLHEGDVVVVQGKSGCGKTTFLKCLAHLNLYSGHILFCGKTPKSYGTFLRLLLNLNRGIESVTIGAPIYRTKVAYVPQRPPLLPGSPRDFLATASSFKARRKGKGRKDARSSEDFEHPLKIASSWGIDSQLWDREWTNLSGGETQRIALAIGLGLDTAEVLLLDEPTSALDQDSCLIVERHILDALNSSENPLKAIVWITHSPEQASRVGTRFLQFTGGSSYEEPSPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAV7</accession>
    <name>A0AA38JAV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acetolactate synthase</fullName>
            <ecNumber evidence="13">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1024312</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="13">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAV7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="17">
        <location>
            <begin position="63"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="15">
        <location>
            <begin position="262"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="16">
        <location>
            <begin position="468"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3733087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="650" mass="70582" checksum="B79324572D25F061" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB32</accession>
    <name>A0AA38JB32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1157838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB32"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041374716" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="25"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="312"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="549"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="779"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3724310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="844" mass="90215" checksum="0FB5E4DC3D0B7119" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBU0</accession>
    <name>A0AA38JBU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1067375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBU0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="468" mass="52097" checksum="9F9977668FDAF04F" modified="2024-01-24" version="1">MSRSSYRLEKPKRQPPAPLQFEHSSYHPKTGLSTHPSPTLLYDLPSAISLSPPTSPTSVTRLASPPTSPGRSRPHRSGRPTPPPGGRKRSVTPMGVATSDLEDFSTYCRNWYFKQDEEAGRLMTQTMANLPPAQRAPYSRLQASIRSAYHRSVNARRTAEFRAHLSATQPGVSLTPYARANPRGSDAQKERYQSFERFVRSWCSMGMPGPQPFFQALWAVMRLQVVPENIGGAGRHRIEWEFDDAVLKEAAGKDFMLEAIDILKGVLAFEEVPSSRMSSPPSGEENPDVTLAHSRSRSSFLPERKVSDTLLPKRARAPSDPFLDTPMLSRSVGSSSSNMTSLLVSDNSEEPLVPASTLNEDVTPMLETPGDDSEEECMRTWTSPDLTNPEYLNLLKVFPSHITRRTLPYFPVSPKKSSDLEAGLDDAADGKQVRCGTGTLGISSMQRGDGWEGGWWTRFILWWRRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC21</accession>
    <name>A0AA38JC21_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrpF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_560415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC21"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3726517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="381" mass="40825" checksum="9FEA1CCF11600672" modified="2024-01-24" version="1">MNSSTSTVRRLARIIPATFLRGGTSKGIFLQQSHLPRDKSKWDEIFLGLMGSPDAEYGRQLNGMGGGISSLSKICVVQPASSKQREALGIDVEYTFVQVGIRDSSIDYSGNCGNLSSMIGVFALDEGMVDSTSHGSDHFTVRAFNTNTQKIVDTTFPIDHESGLADLSLPETCIAGVAGEASQIQLDFHRPSGARTGKLLPSGAPMVQLEIAEGTFRASLVDATNPTVFVDQLEIIEASGIDPSDDKRLQLLEALRREGAIRMGLDPNAQAQPKIAMLNSPKASDDAADIEILALSMGVPHKAVPMTVGLCLGVAANTRGTLPYTLRRITPVLDTSKLKLVKLRHPGGIVEVGATFDMQGEVESASVIRTGRRLMTGQVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCS3</accession>
    <name>A0AA38JCS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1063614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCS3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041221759" evidence="1">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="124" mass="13692" checksum="8C1873A31070BB13" modified="2024-01-24" version="1" fragment="single">MYASLPALRPLLISTLFAVFTSVLTAEYEVSAFYDSQCSVNDVGHLTGSWNGTVTEISEWEETPHGRCLKFDKALPEGCTVTVSGPRILHDLVVDGERYFSGPIARNQRKTGLSFTKMKIECAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE71</accession>
    <name>A0AA38JE71_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP/chorismate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1133653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE71"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3723546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="128" mass="13354" checksum="286907DEFC80E8E0" modified="2024-01-24" version="1">MSTHPSLTVVSTSDAPGAIGPYSQAIKVGDLLFVSGCIPLDPKTGQIVEGIEEQTAQALKNLTAVVNAGGSEIGKVVKTTVFLKDMNDFVTVNGIYAAAFGSHKPARSAVEVSRLPKDVLVEVECIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFF0</accession>
    <name>A0AA38JFF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1194241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFF0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3728058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="930" mass="106149" checksum="7404F8689D58376D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFJ3</accession>
    <name>A0AA38JFJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1084979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFJ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF319">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="50"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3728148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="441" mass="47398" checksum="E119873C5E2274DF" modified="2024-01-24" version="1">MSSTQSYTLKKLDQVPVASSEVAVDFDATPESESKPEPPSPPSFPDGGREAWAVVTGAWLAVFVSFGFLNAFGTYYKENQLSHKSESDIAWIGAFQTFCIYFMGSVFGSIFDKYGAGPLLFIGGIGFSLSCMMQSICKEFWQFFLAQGLLQGLCLSALFSPSFASVNHWFFKRRGLALGIVTSGSSVGGVIWPIAINRLIGEVGFGWALRTCGFIALVLTTIAAFMVKGRLPKRTGSEFFAFGLFRSPAYTTFCNSIVQLATHLTYIGIFFLLFFLPSYGAANGFDSNMIFYSVSVLNAASFFGRILPGMAADSWGRYNIMIITGFISALLAFVSIATRNTASILVVGALYGFTSGNVLSLQGACVPPLLDDPRKIGIGIGQMLSVSAFGALLGPPISGWLIASSGFKSAQIFSGVMLAFGSILLCVTRSLLPMKDSKWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFM6</accession>
    <name>A0AA38JFM6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1225860</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFM6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3726493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="433" mass="46900" checksum="B9ECE115DD7401A8" modified="2024-01-24" version="1">MKPNNFVSTLAAVLFLLFRVAVAHGSGTHKINECTVSPLGDGRDDTDQVLAAISQCGTNGTITLTEGSFNITRKMNWELNSARVHLFGYLNFFPDVEYWLNMSNTYQVVFIQSQSSWFVVTGSDFEIDAHNSGGIQGNGQIWWDFFSNRTREDGDGRPVALTLFNVTRGTVRNFLIESQPFWCNCVAESEDVLYDGMLCNATNTNPEFAGTNLVPNTDGIDTYRSNNVTLLNWDITCGDDCLAIKGNSTNLLVRNVTCNGGNGIAFGSLGQYANLSDIVENVYMEDLKMVRLPASVQPNMGTGVYFKTWTGEVNGVPPTGGGGGTGHVRNVTIQNVNVDQVDIPVHVYQTNGGSASETPSTLMFSGLHFDDWTGNATGNTIVEFVCSPAVNCTDLTFESFIVTPAANEAPRFICQNVTSISGLQAPCNATGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGI4</accession>
    <name>A0AA38JGI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1078316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGI4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052527">
        <property type="entry name" value="Metal_cation-efflux_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847:SF1">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3731637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25384" checksum="621B90FEE6F6BA6A" modified="2024-01-24" version="1">MYYLAGIHISHTQTVEAIVAASTVVTLSRLVKKQSKWFKKAENEGGKTTDRSNTFMGRFVTRVHSYAIMAAPLSYLVAVVSNKFVQPEWYTKASLNIPAIEADTRLGIRIAAAVGFLGSVWCHEIILRELGKQFHFIAVRQNANVVSTGPYAVVRHPLYTTLLGQLAILSVAYWSWIPLASFGICIGAFGYKMALEERLIEEDPTMRDAYTAYKTKVPYKIIPYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGP7</accession>
    <name>A0AA38JGP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1082244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGP7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041335108" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="93" mass="10119" checksum="8080645C698513FF" modified="2024-01-24" version="1">MRFTIASFMFVVVAALLTMFSVEAAAVPRPQARAPEQPVEVVTRAAAEPGPNVAARMHARDFHARAPVPVDVNNGAASVEKRGRVHARDFRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGR1</accession>
    <name>A0AA38JGR1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_992882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGR1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3734649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="293" mass="32191" checksum="C7B18FF7E46AE267" modified="2024-01-24" version="1">MTSPVLEKLSSNKSFEGELIKYKFKSAALGGLPANFNLFLPTNASDSDKVPVLIYLAGLTCTEDNGSAQKGSFLGPASSQGIAILFPDTSPRGAGIDGEDDHWDFGTGAGFYLNATNPKFAAHYNMYTHITLELPEVIEAAGIPIDWKRQSIFGHSMGGHGALTMYLTSPQKQYRSASAFSPVSNPTKCPWGEKAFKGYLQGGIEEAKDKYDATELISKNKEPVHILIDFGTADNFYKQGQLLPENFLKAARDAGYDEFQVRVRSQEGYDHSYYFISTFASDHVHFHANFLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGU2</accession>
    <name>A0AA38JGU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1000991</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGU2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF3">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3729027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="346" mass="38921" checksum="4B18E820CF8A5F78" modified="2024-01-24" version="1">MLRPSSAGPSGLSQNQSFCRSPSQVSSQPTFLHTPRNQSSQSYTRRLRLANLIRPWLPIILYAMTSFVFLIAIAFYKAELFSALDELSRWLQADTTYGQAVLFFLIFLTTFPPIPLYSTLIILSGYTFGPWTGAVISYFAALSGALVVFLLSRTLLRESISRWLSSTCTLKRVVRAIEKRPKLLFLIRLAPYPYNVMNCLLAASPTLTLRTYTLCTALSLFKVIIHSSLGASIHSFKDYHMVLSHEKEESHADTMARMWTIFGIALCVAIFVYLSYVARKAVDEELEDGDDEESVAFLSPEGNGDLEQCDTDDHPAMSETHPHQFISPRPSMTLENHPHPSPVRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGU4</accession>
    <name>A0AA38JGU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_445290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="353" mass="40414" checksum="1AAAEDE0DBF36B94" modified="2024-01-24" version="1">MELFPPQSQSYILAFQFSSWYPVFHSNSIKSTIIRPLSQDFLNYLNADQVFVPKGSEDVSVESSLSDDEDEDEGSADSDENIYEFLELDEKIRAVVKEYGAVFPKLNFSSPKDASWILPASSPLKCTSPADVYLLLKSSDFVSHDLSRSTVFDGCEEVASESYELELVLRKWYSVDRSRELRCFVRDNALLGISQRDTNYYDFLNDPNTHSKVMNTTMEFWKTKIQPKWKAETSYVFDLLLTRDLSRAHIIDFNPYAPRTDPLLFSYEELKDILSAHRSTDASNDSTLLPQFRVIDSPLHPAASCKAPANQHNMVPFEALSLSNGRDIEDFKEIWEKSIKESLQEEQNDNEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH18</accession>
    <name>A0AA38JH18_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carnitine acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1062010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH18"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000147">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="727" mass="81343" checksum="8BC230F22EB1B146" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH34</accession>
    <name>A0AA38JH34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAMM1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1062060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH34"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="365" mass="41161" checksum="AA0624524F1CC277" modified="2024-01-24" version="1">MFIALFRQPYLKTNRGVIRLFSNNIRMASDTPLTKKARTEKIIGTHNGTFHCDEALAVFLLRHTAAYRDSEVKRSRDPAVLDTCDIVVDVGAVYDESKQRFDHHQRGFEEVFGWGFNTKLSSAGLVYKHFGKEIVSNHTQLPVEHPSIQTLWLKIYKELIESIDANDNGISQYTTDLKPRYRVRTDLSSRVAHLNPPWNKSLNAQGMDAQFEKASSLTGAEFLDRLEYYANAWLPARDLLISAIQSSKQKVDSLGKIILLESFLPWKEHLFDLESEDTSSTPPAATYIVYPDEFGGNWRVQAVPISSESFESRKALPEKWRGLRDDVFSETSGIPGGIFVHASGFIGGNKTKEGALQMAKVALEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH98</accession>
    <name>A0AA38JH98_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TKL/TKL-ccin protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1083482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH98"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="700"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115911" checksum="919FDAD6F5F8D93E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHQ6</accession>
    <name>A0AA38JHQ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_861109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHQ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="549" mass="59659" checksum="3F8322F580731B90" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHW7</accession>
    <name>A0AA38JHW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1051433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHW7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3736301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="830" mass="91715" checksum="233C72ADCF503891" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHX6</accession>
    <name>A0AA38JHX6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_987767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHX6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="197"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="408" mass="46682" checksum="E063FE974BE8BEF2" modified="2024-01-24" version="1">MDDQRQQDDWENNRNDRLPSFTEVLSRRTRPPVDLFMFYLFLQREGAEDILDFWLDVQQHENLCRAYFKDVRKSGRTIKEDWPQYWDYARRRGSIYGTVVGLNTDGMHTKRSTASTGELLSEQDKRNLAATDEKAAGRSTSPRLTPGISEHTHVASMSPTNDRPTTPFSLSGRTPTLFNLKRASRAPTVIPRSSAITRQDLIASAERIYFRYLSPAANTVNSQENHEIYLPPSLRIHSFPLSSSAEPRSQSEMAIMAQIPDMFHAQKEYCFRAMEQDAFPRFLRAKAFGNLTPISALVRLILGLVMLWIGLAAAFSLVFLDVRPKSKRFFLFIPFTFAILFLVSHQYELDPILVFLGQSETTPFRTLRIKEPYVKKLLLGRAIWVSVLVAAFVAALTLIFWAVPGHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIN2</accession>
    <name>A0AA38JIN2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1129288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIN2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="10">
        <location>
            <begin position="34"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3736586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="299" mass="33354" checksum="72E4D6D407CDFDF7" modified="2024-01-24" version="1">MVHKQKPRLLTWVPPPSSRPRISLGNGTRGGRGGKSMFGLVLGTLNKAKTESKEREASDAAKRRQLLEARLQAKLRNETAEVRKQEEAKRDKTLAVRKEEELGVKLSVYRLRRTRTPYLANFLCTSDVIPDELTMEDEVEQSDSQFHAKILEKAKPPRSHPPPLYYLPKKLLPSQEAFLKKRKEQIEAASAAEWSAFVTERDAGVKDIRELREKVLNATTAQADEKEEKNVTNGGVKGHGDDVNMDMDNSNKVESTEPTSIEVTSGEKDKEGSGAAAMDVDAKPTSTQPENDNDDAVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJJ4</accession>
    <name>A0AA38JJJ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1038094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJJ4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34653" checksum="4ED40C599A4469FD" modified="2024-01-24" version="1">MPDIRFIRFRATGRSHSNLQKADEKLDLLPSSTILFMTDPEKRGSMSSDDAGTVLSSPSKAQSFWNYLNTEVEPKECTGPLAAFCFMTGFIDAISFSSVFVWCGFQTGNFVQLSLALARLFSVGPGGAVDRTFHKADQQALTSLLAFNVGAFVGRLGDRIGSHKRIWLVFGTFLQTLFTMAAALTIWKAGQPSVADDRGDPSWTNVLSFVCLAFMSMSLGTQGIIGKRLNTQFTTTIVLTTVWVELMADPGLFHRKKVITRDHKLIAASSLFIGGFVSRAILDKVGSAGALGVGTGVRLLITLSWLLVPGKKAPVSKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKI4</accession>
    <name>A0AA38JKI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1129262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKI4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="144"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="241"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3737169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="334" mass="36076" checksum="F4F241AAFFD146DB" modified="2024-01-24" version="1">MHESYAKLVGAATGSTMTALTMTPFDVVKTRLQTQRPVERPLIFPQPPPNTCCQPSGKPCVRNMSSMARPLVEEELVCVWENGVYRAERVNGFSDAIRHVWRAEGIRGLWKGAGTTLLIGVPSSTSYMLTYDHLQKVILPPFLPAPVVPLMAGVIARGAISSLASPLEMIRTNLQSTPPSPSNPHTLRSVLSSIRGLVRAQGIPVLYRGLGATLWRDIPFSGLYWATYESLKKSFARQGHQGAWVAFVSGALSGSAAALMTSPMDVIKTRRQALVMTGSTSEITATFPLVKHIIHSEGVSALFAGLAPRIVKIAPACGIMIACFEGVGRFLSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKM7</accession>
    <name>A0AA38JKM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1035505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKM7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="896" mass="99803" checksum="4BE4C3D4B56904F4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLD4</accession>
    <name>A0AA38JLD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1072815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLD4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="66"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="487" mass="55404" checksum="87EA9242B7AB2840" modified="2024-01-24" version="1">MSKRKISSAQELTEGTPSKSKRRLDAYSDSPTTSHIAKQTMVAQAGFLPYSSVTPQTFLSKSIPFQQPMPLTSFSYTPDHIQEFNDSALRYFRPPPPNAHLGYGYERWVRRPEGRSRIDSLLRAVDRVTDGQRKKMNLEDVGVVAWRGVITRILTAPYEDREGWEMNVMLIKGTLYLEEHRSESLITEKNNIKPQHRKRMYYGYAFESYCTTDTDMPSYSKTASTRSNEPSHVAHVGDTLGWGGDVNTNIQWCSIVRTKLGDTRFIIGGEVDCSDGQYKGTTDTFVELKTSMSIRGAADEENFERKLLKFYFQSFLLGVPKIVVGFRTPSGQLTSTQSFQTMQIPRMVREKAENKRISTPWDPSLCLAWCHHFLAYLKRTLAACESDDIPNHQNPAEDPEEKVQHDYSPIPTQVWRVSFLPGEGARLVKLDRSDVEKVVNGEDRVGFIPRWYWDKIKSSSAYASHSDPIRSTTTEQPVQGAVGGWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLS4</accession>
    <name>A0AA38JLS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1072443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLS4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="197" mass="22348" checksum="2A55C1B634AA29E5" modified="2024-01-24" version="1">MYTSSSAERTSVPQSRHQVLYIAFAEFLFSITFLVVGIFLLYTLGEQILDADAVALNLHIFAYFFLGLSTTLGISGSLHRSRSLVAMFCSMTLAQLVFGLGSGIYCLAILFNDPGDIISRLLHNKCSHLDHFSQAFCDRTPMMKYLTLALFMQMWLIEILGVYYAQGYVQELLDEETDGVKEVDYEFDYDYAYYGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM69</accession>
    <name>A0AA38JM69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1151918</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3734772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="538" mass="60687" checksum="DD95F6075BE4E822" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMM9</accession>
    <name>A0AA38JMM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1133227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMM9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3727209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="895" mass="102384" checksum="3DFDD38A2E81DC40" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMR6</accession>
    <name>A0AA38JMR6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_311855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMR6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3732486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="415" mass="46907" checksum="68B40D1DC459AC68" modified="2024-01-24" version="1">MVATPCAVPRLSSGSRLEIAGVVIAIIVAYFYLHRRRVHHLHHVRRLPNPPGPKPAPIIGNLFDIPREKESAAYNKMANDYGELTYLNVLGKSILVVNNYTTVQELFDKRSANYSDRYQAPMMELMGWSWNFGLMSYGSRWKMHRAMFHRQFQSSTVSVFWPTQLKEAHKLLRRILHNPKDLANHLRFNSAGIIMNVAYGIEIEDKDDHYITVAETALDGMAKAANPGAFLVDIFPILKYVPSWIPGADFQRKAAFWRKSVLEMRDAPFETVTKARKFGISTSSFASNLLADLELRRDLDEVALSKELETIRNCAGLAYAGTESIASSLSSFMLAMMLYPEVQEKARQELDAVVGLERLPDFSDRGTLPYIDAVVKEVFRWNPVAPLGLPHMTTKDDEFKGYHIPAGTLVLGNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMS5</accession>
    <name>A0AA38JMS5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_542072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMS5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041446541" evidence="5">
        <location>
            <begin position="17"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3727299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="384" mass="40372" checksum="8171941728E53A2F" modified="2024-01-24" version="1">MLRALCILGFALFVIADNPIESGPQKITLASRIAPLGKSLKRRALSPSNIPLADFFKGTDLQWFGNITVGTPPQDVTVVFDTGSSTLEFASTLCSTCTSQIQFDPSQSSTFVDGGRTSTITFATGVGVDPVVGDNYQLNLRSATDTVSVGGLTSPNVSLFLITEQTPTFDIDPFSGIQGMGARAQGFFASLIARGLPSLFGLFLTPLSVGNAELTIGGIDETKFSSNLTFASQAGTGAAWELRSPGISVNGKTTSLLNTPRTIIFDSGTSNVLFDTATAEAMYALISPDIQPNPAEPGTYGIACDRIPTLPAVIDVTFTSQQGTPFNLTIPSSELSVGPFASNSSLCQTLINAFDGLELVGGSLLKHYYSVWDVGNQRMGFAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMV7</accession>
    <name>A0AA38JMV7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Receptor-activated Ca2+-permeable cation channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_991286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMV7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="246"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="700"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="84825" checksum="488EAA991F60A687" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNX2</accession>
    <name>A0AA38JNX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate esterase family 9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1056906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNX2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="388"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="927" mass="101311" checksum="5AABFD476A777449" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP20</accession>
    <name>A0AA38JP20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1065237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="220" mass="24995" checksum="750B181F151D7EC3" modified="2024-01-24" version="1">MIAAYRRQRLADEKALDKKSRFGRVYPIGRDDYTREVTEASKIDEEGDDAEQGTAVVCFIGSSSIPRSDRAFEHVKTLAARYPRSKFVSIVGDKCIPNLPESRVPMFIVYKKGEIRNQVVAWGADRERRIEGKEHRFISYILADVEAELEALLLVTGALYPPERRAPEDRRKEGSSGEEDEEDLDRSSRMRSAATSVNGRTKKNVRGKEKDSDSDFDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP40</accession>
    <name>A0AA38JP40_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1036597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP40"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="132" mass="15310" checksum="39EA3ABE6274F6A8" modified="2024-01-24" version="1">MKTSIGLYFLGRTQLPVQESPHTEELSYRKIQKNLNLTNAVCVYDLYEDSLTAYREAVTKVTDALKSMEVPEADWPRNLRTSERNKDVTLTVFEQMELERDLAAEARQVGYQFWLGSLNTFITGQDLNYLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQI8</accession>
    <name>A0AA38JQI8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_374877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQI8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="264"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="363"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="576" mass="62732" checksum="A8F44061030F39D4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQP7</accession>
    <name>A0AA38JQP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_991777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQP7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="499" mass="54778" checksum="E3606F202377810C" modified="2024-01-24" version="1">MHSTNEAQALEDMDDNVPRDKFAKLWAVVMFLDKYGVEARGIERVLPDQRTQTSPLAPFWMWLAANMTISTFAIGVLAQSIFFLGLKEAALTIIFFNLLCTLPVAYFSTWGAKLGLRQLTLSRFSFGYATAQLPIVLNCIACVGWSIVNSIVGAQTLRAVSTSHQIPTAAGIVVIAILTIVVSFMGYRVVHLYEQYSWIPVVIIFFIYLGQIARFTESDFGGSGSVEAGNVLSFGATVAGFALGWTSLAADYTVRMPEDMSAYKIFFWTYLGLNTPLILVEILGAAAMTTFAQKPTWEDAFNNNSVGGLLGAGLAGPMGGFGSFLLVLLALSIVANNIPNMYSLALTFQNLHPYAQAIPRIVIVIIGSVIYIVLAIVGASHFEEWLDTLLVILSYWLAIFSTILIEEHLIFRKGKWSNYVPDDFNNWRKLPLGIASFLALGCGVAGAVLGMAQVWYVGVIGRMIGDPEFGGDIGFELAFAFTAVTYPPLRYLEKKWWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR22</accession>
    <name>A0AA38JR22_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1036988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR22"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="490" mass="53429" checksum="D27DE78DF9CB7AE1" modified="2024-01-24" version="1">MSMPVPSTAEDPPLTGTSSGVQLARDANLLIRTYIPSSLSLHQPYIGPPIPLPFCIPQVSVNPNDQSTFARGYNDALNDIGIPQDVFLNFIDGLNMAIIASPPLRVVDMAGKIIGFIPYHWAMIAGALISTAAGVAMHVLSKTLTDRYLRAANLNLFKPRGLSVRLCTTPAMFALLASSESKARSKLNKFGRGVGSVLLKLPIPVINPIASTIIHAIADKPPVISPSGREGDPINDPVLRRRVAMTEGLSLPLNMDGLPPPSKPDGVIDTMASWGVRFDTAREKFSEKNIERRRRALESIKQAGIEPPSRSMGLLGAATSSRSGLQPLSSTSVRSTSSSSSSGFKSMASTALNTVNDLRLQKEIRDERIEQQRNASLRNSGLGNVGLGAILGSKKTRMEQKVADADLLEHWGTDKILWVVIMASDKDEEIADIAIAEDPADEERIDDTTWRERMAIERNEMELEDMQVFEQQQRQSQEVFTDAEPSRNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR36</accession>
    <name>A0AA38JR36_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_66989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR36"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="335" mass="36607" checksum="3A5664048424A30F" modified="2024-01-24" version="1">MPRASSKRIDESSRMCSECGIILAHQYSMPRHMKTHGVGKNQTKHKCSWAGCSFETLQRSNLNAHYRTHSNDKSQVCPECDFKACYPSSLTRHRRWIHNYVPQPRKARATQKTQSSRTTSPPSEFILDFSSSSTSSNPASASTAFTSPDSTHTADCTAGSQHSIEHETDWRCENGGFLEDIVRLPIPRPLLPAIDTAPALEGPSDIFSRSSYELPLLLGGPSFLPSPIDGQTFTSSSNGWQPQYPSQDYDACPALQHSPCELLFEPATGFEALLLPTSTPEEGFRFGYEESFLQASGSVSAWSGSTGGAGSVTNLPSLPLNGGSSWDELNVPLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRC4</accession>
    <name>A0AA38JRC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_990926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRC4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="278" mass="29619" checksum="D414C21D7819F60F" modified="2024-01-24" version="1">MPSFTSTIEDYSPVIIYSPDWQQGSSQSDTLASSYSTSSFFATSTSGGTASFTFNGTGVELFGSKRGNHGLYQVTIDGTVFPAASGEATDPGIFQTSLFSKTDLEQGLHTVILENQGSSGQFVDLDFITWHGSIGESNEQLSVTTVQDDNDSFVYSPGNAWSDTPDNLGFFSGSSGHVTSTPGAFLTYIYLLQCLGDGVSLYGPVGPAYAPFSIQLNGDSLSFSAQKNFNMTQTLLYHTDGLGSGSHTLKLLFQPSATGQIFAIDYAEVYTTPSIAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT60</accession>
    <name>A0AA38JT60_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1057178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT60"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="123" mass="13984" checksum="17BA2B106B1B9125" modified="2024-01-24" version="1" fragment="single">MFPITPIIKFRFGHAIGFFHSISKPQFISDPFGNSVTSDSFGTSVTYESFGIPSCLLFSVLSSLIYPDLFAFASRWDVWIKRGISNKFHPTSFRSFGTFSLAILPDFLLPSFLYPFRFILANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUK1</accession>
    <name>A0AA38JUK1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1054857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUK1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000432">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.10, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3735891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="326" mass="36158" checksum="F54F48E182594E87" modified="2024-01-24" version="1">MGKRSNFSGLARFVQEANIPSESSHTLVENVRITTKRSMEPLDCERPPKKTKSEATKDNTIVKLVQKYDMSGSVPVFSTMNEVPDNLKKYYAQRERFFSLYSTPPGCLLDEEGWYSVTPERIADQIAERCRCDTILDAFCGVGGNAIAFAKTCQRVIALDISPTRLALARHNAQIYGVAHHIEFILADYISFAKTLISSPKTTASRKIDVVFLSPPWGGPSYLSGSSLPSDSDSSSTADSVPFGLSDIQPIHGADLFDLSRRISTNIAYYLPRNVNLNEVSALIKHDFAKDSAQEFIEVEEEWMGRKLKALTCYFGGLANGQSELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVG0</accession>
    <name>A0AA38JVG0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_988593</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVG0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="64"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3736915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="375" mass="41854" checksum="919B32275B134605" modified="2024-01-24" version="1">MLRLLAHQKSVPFRRYLAIHAASIPSTVTRHDWTRQEIQEIFDAPLMDLVFRAASVHRKYQDANKIQLCTLMNIKTGGCTEDCSYCSQSSRYSTPTKASRLLDIEPVIEAARKAKENGSTRFCMGAAWRDLAGRKRGFERILQMVREVRGMGMEVCTTLGMLSPDQARQLKEAGLTAYNHNLDTSREFYPQVITSRSYDERLSTIDAVRDAGISVCSGGILGLGEKDEDRVGLIWEVSNMPEHPESFPVNALVPIAGTPLEKNEPVSYHTLVRTIAAARVVLPTTIIRLAAGRNTMPESEQAMCFMAGANAIFTGEQMLTTPCSPWDEDKAMMDRWGLEGMRSFEQVNVARKEQPAATLFDESRNKERASVVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZ65</accession>
    <name>A0AA38JZ65_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_821351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZ65"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="173" mass="19202" checksum="C3D6846DD2E912AE" modified="2024-01-24" version="1">MIPPPIQQMEMQALPSSIPLLIFSSLGVSTAGSALAVTGLILSASPLLWIIPVTFVATFTHHITMLTIARVEPHGSERLYSRSRIICGFMIAVSWTLSVCVVVTAIVLKAMNVFPKYKMHVGIWLMASCAALAFVEAVISWIVAIFNQKERKRITYAAKWRPLNMDRSWSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZL0</accession>
    <name>A0AA38JZL0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_990546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZL0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="25"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="543" mass="58130" checksum="07A18B058F4BDD4E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQU4</accession>
    <name>A0AA38MQU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1228006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041283187" evidence="2">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3714594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="282" mass="29926" checksum="C967869A60D7DD72" modified="2024-01-24" version="1">MRFELLQVAQAIALFSTSVLASGTSSSNFTTPGSLGILRFNPGAEDMHTILARAERETPQWQGFVRGKRLPLGVPSTSESRSTPSNLTPRAGPPPGPSEATIGYLHIRSALDGTSLGYAASAFNSFGEYGPTTSSQRLKVTIDTSMVNQTISIATTNGQDADLLFMVGITGFSNDASGLNPGKYNYVYVGAGGQTAVNVSPRSGDNSFSRATGNPEGIESAIFVLQSNFDIVPFWINGDGSKPNTSLGLHENVLFLTGDQDIFVKTFGSVTWVILSFEPELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MT64</accession>
    <name>A0AA38MT64_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1079979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MT64"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="121" mass="13915" checksum="96C369F169C51D17" modified="2024-01-24" version="1" fragment="single">MVGSLNPSENIVETFHFVSIVVETIFAVIAQNFGRSIRVIPMLPNPMLPIHVPLVPVLYRATYEFRPLSFRFPAEVFGFLNFELSFIMFYILFTIFLLCFRIPRSSESPSSLTLVILMLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTP4</accession>
    <name>A0AA38MTP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1074209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTP4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="261"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="526" mass="59735" checksum="0D4F1355FFA9C340" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTT4</accession>
    <name>A0AA38MTT4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1172324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000149">
        <property type="protein sequence ID" value="KAJ3709989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTT4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="450" mass="48890" checksum="69A3A9EFCF6EED54" modified="2024-01-24" version="1">MSENLTLNQLVQARKQQQQLQSQLAPQTPLSQRHVFSDSLGNMTPLPGPNSMPFSIGSNNFEGGSSTPFATGSWQSQSFSESMYGSGGSAAGNSARSANGEMAGFIGSAQAVSMDVTRAFIDKLKSVSNLSDDGNEALETYFQAPTLAERLGIQYASTLSIKLMLSRMVEEKEMNWAVSSDLKKIVIKYVKAYLLSSMTKSYIHCAPERLIISALRAGRVRELPSEDDITANATLKSHIQRAFVTARSQIKNHILATTQYAPKSRVPEDEQDLGTVVETLIGGSSDIPISLALMHRVAVMRAVIDTQSQVIGNAEKFWPLVDAQMASLLGVSETVMIMHGSDFHIVYEMDVEKYGKPRTKPIDVSDPKYSWTSYVKKINELASKIPLIDNGGKASWGKKRKRGCADMGLVRNKPGTGSEGNDDDINDNDIDEVANGVGSVDNESDPQPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTU3</accession>
    <name>A0AA38MTU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1035039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000139">
        <property type="protein sequence ID" value="KAJ3710360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTU3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF152">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3710360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="533" mass="60947" checksum="F3EC5F645DE30F4D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV51</accession>
    <name>A0AA38MV51_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1165572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000103">
        <property type="protein sequence ID" value="KAJ3713004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV51"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="426" mass="47706" checksum="CCE1864BFFDA1D14" modified="2024-01-24" version="1">MASNSNGSSNPHVFVLHSPHCGYEYAEIRTVLRNQVMLYDNAPHGYYITQDHQENQYLFPFASGADATKAFHEALIAQDLPKTKSTDDTARFNPLPMRTGQQPPRSSDNSLTSNYPSRIQSSRMAMPKNSTRTRSTPRLPSQYIQESDINSLLPLHGIDFGSKLPSGGQEVFYYLRADVNDTTPGLNELEFKLHIDTGDIHSWLFLHNFEYIKNVTVSKRDALIAHTSTQWPASCNPKALGVTWPFTVKHPESVRNMPENVIKYGSNGYVVKHDGPVKSNIVVTLHGWDWEKQDKSEDGFSIQDGFDFVIAANEEIILQGFDGNIGLGPRQGYAQLGTSRNFLAALNANRRINNSDTSVFIIRLVHPYDLFHAPMDCDLRNILSFGSGFPLRAPVNPDAHFSLPIPTVNIYADNSARPTSWDVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVE9</accession>
    <name>A0AA38MVE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_118130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVE9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="6"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="783"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="916"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3734369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1026" mass="111833" checksum="FB46C039F128BB5D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW53</accession>
    <name>A0AA38MW53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_805135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000076">
        <property type="protein sequence ID" value="KAJ3716797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW53"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3716797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="361" mass="40128" checksum="E6F5052E93B7A9DC" modified="2024-01-24" version="1">MVVSLHQSDIKQLSATALLFASWVNMGLYGVELVLCAYCLGWHCCMDNLPAGPTNTSGSPILQSNGDLRWVRKQSRLKRVGSKWFIIGALVNDTICTVALCLDTYFIVQFSNSSESMSSNNRLWPTALWILTTSLATTFEQTYFLHRYWTISKNWIITTTLAGLILCNFIFILIIDAAFIPTSNNSLVLEKLDAPFVSAIIITVVDISLAVILVWKLKSVKTTRLPTQRLIRKICIFVVGYGCITAVSSALMLVMWVVNVNGYMSIVYCLGRVYSLTVLCNFLFVSGWRNEAATADFHGELDSNLTVKASELDQIPWFKITAPSGLPTRNSSPLHQMQPPSNQTVIAQKDMLAPSFSVDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWC6</accession>
    <name>A0AA38MWC6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1129985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWC6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="433"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="485"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3735659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="605" mass="65955" checksum="5A03571BE0E141F3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWI1</accession>
    <name>A0AA38MWI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 11">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1113420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 11"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWI1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="12">
        <location>
            <begin position="406"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3735734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="477" mass="53220" checksum="0AC1575F892BBEF8" modified="2024-01-24" version="1">MGFSLEAWCQFSRHLGRAVRSNRHVPPIRSFSNILHDLSSRGFIQQVTSPTELENALCSRQVVYCGVDPSASSLHVGNLVPLMCLLHFQLGGHTIIPLIGGATGLVGDPSGRKTEREPVNVAQVERNVDLLTENIRAFFRRGLLYAKSRLLSVSGITSDPEVKSNLEWHKNFTMLEFLREVGVHARINTMLSKESVKTRLESSAGISFTEFTYQLLQAYDFYHLHRAFGCTVQIGGSDQWGNIVAGLEFINRLNSSKSPEDQKAFGITTPLLTTSSGEKFGKSTGNAIWLDSQLTSIFDFYQYFLKVEDFDVERYLKIFTLLPLSEIELIMEAHQSEPDQRIPQRRLAAEVTELIHGAQGVQRAETMTKVVFRHPNSKDHTFDAQSLIDAFTGDPRMSLCEENELTSVPLVKLASKYGLVPSTSAARHLVQSKGLYFNGHVVPDVHFTLKRNNLLDDRAVMVRAGKDKVIILAAAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXA4</accession>
    <name>A0AA38MXA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1092242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXA4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3722771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="97" mass="11362" checksum="0ED0A636B51A38C4" modified="2024-01-24" version="1">MHSVCLVYIPTQFLPLSHPIPLVSQFFYFLNRIKTPQIRVVAFHCLSSETSSAEPSLHDTYDWYDGINEIPNYIIDVCLARTYMTQCMQTIVFYHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXY4</accession>
    <name>A0AA38MXY4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1042166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXY4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="234"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="832" mass="93860" checksum="221D53D1BEFD8180" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYL5</accession>
    <name>A0AA38MYL5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1081539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYL5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3731115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="228" mass="26085" checksum="1CB2D16712AF0C88" modified="2024-01-24" version="1">MDPQNLENLNQMLDHESNIREKIREQVNEFDKKTRTVVGILSKIHSTHSESIPSLIETARPILHSCSETIADLVSLIPPNQFWRWKDMWCNSLRTAVFAAALSEYLTKGSLISLESTSNILGMQEKWKDRVDLAVEDYLHGLITMVNELSRLAVNAVILGDFEQPLKISAFVKELYSGFSVLNLKNDTLRRRFDSLKYDMKKIEEVVYDVSLRKLVSKDSPVKPTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYN0</accession>
    <name>A0AA38MYN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1157401</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYN0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="309"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3725664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="596" mass="65669" checksum="429CFEA0A24D5479" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZR2</accession>
    <name>A0AA38MZR2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1027673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZR2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="33"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3730952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="146" mass="16726" checksum="4D62407A72E48300" modified="2024-01-24" version="1">MSIYFYEPFYNFNRAFDRFFETTFPQNGERSDGVARSIHPKMDLHEDASKNTITATFELPGLRKEDVNVDVHDGRLTISGETKPSSEHREEGYAVRERKSGKFSRMLRLPRGVNEEDIKASMKDGVLTVIFPKVVPEAQPKKITIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N130</accession>
    <name>A0AA38N130_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1132096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N130"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29253" checksum="B71B85714966D6A4" modified="2024-01-24" version="1">MSSLKHENKLIQRGSSSSPTPFSRSVFVFFRALDLPLQYSIISSRALAAPLIRELGGAAIPPTGRPLYLLGTNTGLSPQRAILFGMAIGSVVKQSHWAMSISRDPMPTGASAAVGVFNAFSNAINMILFTNAATSALAYPSVDGDETKLSVPTLVGLGMYALGMVLEWGSEMQRLRFKKDPINKGRVYSGGLFGLARHINYGGYVLWRGGFALAAAGWTWGAIVAGFHIWNFVSSSIPELDEYCSNRYNEQWAQYKRAVPYKLFPFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N174</accession>
    <name>A0AA38N174_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_997548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N174"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="327" mass="38169" checksum="04F99A65F2AC0A2E" modified="2024-01-24" version="1">MVALTFASSGDRSNDFQQCLLRCDNTECTENSLPLILKMTRWTCADNCKYLCMHEITAQDVASDTPIQQYYGKWPFHRFVAQEPASVAFSVLNFYTHVKGAQRLRMELDDPHPMKIYYMGWSFVSINTWIWSCLFHTRDTAFTEKMDYFSAALTILVALYFTVVRLFHLYAPSHPRNTLIMHGHQPENRVRLKSWSAACVLIYVGHISYLNHLERFDYSYNVKFNLVIGLAHNALWLCYSLPSSISFLRRFLGRSKRYRPHFVYKPALLVSLLVAAMALELLDFPPWALIIDAHSLWHLSTAPLAYMWYQFLIEDASDDCWKEQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N185</accession>
    <name>A0AA38N185_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_994953</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 12">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N185"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="295"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3733561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="348" mass="36794" checksum="316C951A448D186D" modified="2024-01-24" version="1">MLPRRSFVVFRSFLSRNYASAPPPHALIFLEHRQGDVDSGSLSALTAASLLGGKVTGLVVGSPEYVPAVVDKVKKLKGLTSLLHSTSDLYAQQLPETLSPLLEKLLSDSEYTHVISTPSSLAKSLLPRVAAKLDVPSVSEITSLEHDSSSNSTTFTRPIYAGNAISTVRLSSSVPIKFFTVRATNFDPAPSEESQEIEVKAVDPVDVPECPVEHISTQLSKSDRPDLSVAGRVVSGGRPLKNAETFAATLNPLADVLGAAVGASRAAVDAGYADNSLQVGQTGKVVAPELYMAIGISGAIQHLAGMKDSKMIVAVNKDPDAPIFQVADVGLVADLYEAVPQIIEKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1V1</accession>
    <name>A0AA38N1V1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RanBP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_118422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1V1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000018">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="24196" checksum="5D95FE0C46AACC91" modified="2024-01-24" version="1">MENTDPLAPREEEADVHFEPVIKLTEQVDTKTHEEDEDVLFKMRAKLFRFDAASSEWKERGTGDVRLLAHKETKKVRLVMRRDKTLKVCANHSISANMSLQPNIGSDRSWVWKVAADYSESPPTSETLAIRFANSDNANEFREERGIQGRGEEVDCPRCCISSLLLPWKFISRTLASSLVFHISGEYCMIIILETHSKVDTVSTVRWQIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1V2</accession>
    <name>A0AA38N1V2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome oxidase complex assembly protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_996173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1V2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="208" mass="23275" checksum="6453D3C08F2CC644" modified="2024-01-24" version="1">MNIYPTVFKSLIARRSPFVATALPRQHLQYLSTTSRPGPAAAEAPNVTTYSGTSRPRPYHLKHPPPALKRDLPRLQKTWPTIIAFAIIGVAGWTAFLTYVTNQEKISSSVVKQIMRELREDEEMRAVLGDAIRMQGEWWLNGDPRIIGSISTMQGNIDVSFRIKGSKGSGTVYFTSIRREKGVPFEILRFKVIADDGTIISKAKDTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N239</accession>
    <name>A0AA38N239_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1153225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N239"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000192">
        <property type="entry name" value="CTD small phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="10">
        <location>
            <begin position="343"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3733622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="515" mass="56509" checksum="DB1AD6CCA4EB2EC4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N266</accession>
    <name>A0AA38N266_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1037525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N266"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="339" mass="37921" checksum="01AD612F58B680CD" modified="2024-01-24" version="1">MASPEDVHRLRQLKESELLQEAWDHWTSTLKALENIQPLLSDPDPAMMSLAAEEAVELDQKLTTILKHTFPSLLVPPSTTANLSALVELKSGVGGTESSLFLETLLRMYMRFSQSHSWKASIVANNDNEGGGVKDAIVEIKGLGAYDTLRWESGVHRVQRVPATESGGRVHTSTVAVIVLPLIEEQDAQKEALYSMDDIRLEVMRARGAGGQHVNKTESAVRITHIPTGITVSMQDERSQHQNKRRAFQVLSARLMDRKITREIAERRATKNSLIKSADRSEKIRTYNYAQERVTDHRIGLSIMNLSSVIEGNALQDFTDALKQDFEETTMEDMLESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N280</accession>
    <name>A0AA38N280_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1151922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N280"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52278" checksum="C43F4584376129AB" modified="2024-01-24" version="1">MEVRNSFSSRSIELNPSYQQQNPFDILPDELVINIFTTLRNGCSFPSKWILLVVQLSGVCSRWRNLVIGAPLFWNFCVISSYDSLVLAPLFFERSRLLPLDLIVSYFSSEEIFTLLSSVSGRIQSLEFWFISPDELIDCLPIISADSATGLHQLRILCDPKHDWDCNSPEEHFSILRSAETLRSVVLKGVCSQFSPPLVNLTHLEIHEFSPTFAEFSLLFASNSALTTLCLPGVPRTEWLNEEYSPIDASSLRSLSVGLAEHWGPRTCGCMLTFLKLDNLEYLEITGNCTFSISNHFCSMNGLSRVHTLRLRDLKMDAPDVPLCSALKAVTRVELYNVTKSSVLVARNGAGDSEIYFPKLKSLRCDESNLMQDEGLAELVCSRSGMGLFCIELPSFLKAWPHNKVLAKLDAANIKLLFIEENEAAKGLSFYGSESGEVLHLRPEWIDYDEYDEEDSELDFFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2K8</accession>
    <name>A0AA38N2K8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_37055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2K8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="183"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="414" mass="46083" checksum="889F120C2E91218D" modified="2024-01-24" version="1">MSVTDSVSVFAEGTFEEQVQELVNYLVRTQSDEERAASIRPFQEALTTAEGQKSLSEDEERRKKIFSMIISAIKGLGRGQEKEIEGFFNLIYAHLFSLFSPSSPEAKQLTDTLLKVISSAPSDQTSIKYRILSNLFNALPRNSSLRLSVYNTILDIAVADNSINALHLSRSNVETWLEEWEVSSEDKSAFLQHIVDAYAKSSQPIKSYDYSILYVRSLPPTSEAAKDASIRVIASALRIPSIFEFDALFKLDAIVANKDHELFALLQVFLNDGLSEFKAWETSHPGALGQHDLDRAQLERKIRLLTLASLGFKNIGTNLSYTKIAEAIQVDVSEVEKWVIDVIRAGLLSGKLSQNTQTLHIIRSTARSFEREQWQALEQRLLAWKSGLSSVLDVVASAKRQGGHVSQTVTAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2R2</accession>
    <name>A0AA38N2R2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin synthase</fullName>
            <ecNumber evidence="8">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1038456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2R2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3733608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="687" mass="77053" checksum="32554E621FCE706E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2R5</accession>
    <name>A0AA38N2R5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1068063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2R5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="252" mass="27541" checksum="2B93F91DC43C653F" modified="2024-01-24" version="1">MLSYPQPALNVPQMQDSHHQPSPAPTEAQIVTQTGQGQPSNSVPAARTSRKRKTPPAPEQQPLPPPPPHLQHVLPPPHALMHPLPPGFAYAHPPPGEYTVTGMPPPGPPQPQSAEAAASQNASRPLSNSKRAEQNRKAQRAFRERRDQHVKALESRSQLLDAALASADEANRRWEECRALVDQLRVENAALRAHLAQHLQTLPPPTGIPGLPPPLPQGLQQPPPAQPQHLHSQPAEEKQSEEGREQNTDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N397</accession>
    <name>A0AA38N397_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1053096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N397"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46780" checksum="FC5D8D22FE8975F8" modified="2024-01-24" version="1">MAVFSVRRMGLKRELPLELLYNVIDICAQNSSLNDLKALSLVSRSFNRQARKHIWGHIELPTKGAVRLDRDGRDFSFLVDALSTLPDISSHTKSLHLASHPPTVLYPFLRKLKFGRLQRISIHGYDPRVPFAPSPASLAKLARTNCDIRTLKLSNFRMNPIAFLDLVSQSKLHELRHCTLDVINTTFDDSWDDYLKHPSSEVLDDFIEQRTQTQNVARPSLTSLSLNRITNLPNAAFCSALFRHTHSLFNISSLQRLTLTISSYPPVPLRHFIEVIELCCLSVTSLTIHNWQDVIRSDSTLIATFVNAIDVTFNVYDGASLDIVKYSMELLLEHLAALKSLKRVKFAVESFKEVNFLSQQIADVLAILCREVPGIEEFEVSIRSSDAEYYKCEQRFVWDRERCAMVCMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3S1</accession>
    <name>A0AA38N3S1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_610444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3S1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="719" mass="77933" checksum="24CED4DF610993B1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3U9</accession>
    <name>A0AA38N3U9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Adenylate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1037256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="9">
        <location>
            <begin position="1521"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="1857"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1205"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1423"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1241"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3734928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2221" mass="244702" checksum="C466693BCC5E87B8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N588</accession>
    <name>A0AA38N588_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N588"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38848" checksum="65E7B3EA1D2B3997" modified="2024-01-24" version="1">MSPVNSRANSPSDEEEKAELLLIQKKKEERARREAERKAEEEAEAAAKARLAEIRRKKEEKKREAEEKKKKEELEHRKAEEEAKAAKAVKKAAEKAKKEEERRRVKEESRTAEAARKAAEENRKKAEMDRRMEMAVLVQGQIVRKKKEKQLNSPVSESSTVVVGKKRKRVAMVVVPSGDPKGGDPNPGDNDNYIESDTDDNENPEDPPASPLKQSRCSRCILKALKCELVGPGSASCKGCRKAKVRCLLVPDDYPRRSKRVKVESPVASTSNQVIDNLRTNVRDLNTRINLQEEMLRYLILRVRKLEEANREEDDEEEEEESEEDRVKRTGDRKGKGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5T9</accession>
    <name>A0AA38N5T9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1128744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5T9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="554"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="685" mass="75416" checksum="76AD6A473E74AFC6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1Z5</accession>
    <name>A0AA38J1Z5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_47257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000101">
        <property type="protein sequence ID" value="KAJ3713235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1Z5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="171" mass="19055" checksum="8ABA77C044FA4A2C" modified="2024-01-24" version="1">MRFNPAYLFVLGSIPATLCLTLNVRSDMRTRSYVGLVETPETRAFHQDHGIHLLAARADRNAVHLKFMSGVEGNEKPPPKVLLLVTKLFTAWLGVPLITPEFFNQLSEVPQNGYLILNFWGSGLEHCKESLDGCSVIIGAVTERNQWITIHKGARFLYSTTTESLAVETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3K0</accession>
    <name>A0AA38J3K0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1160928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000093">
        <property type="protein sequence ID" value="KAJ3714033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3K0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3714033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="234" mass="26471" checksum="B10F901EF84B5480" modified="2024-01-24" version="1">MYDSNPSLSTAFDRSIEDNQITIIVDIDFSQLNSAHPNLRDAISLALVSGILGPSPSVEQLNLAFVHAHAFFSYDTSTYNSFIHCAAISSECQPKISNLNRNSSHTYTNIANTTANTTFAASKKKYKPVHRRVRPIQTTLPENFCVVRSFPTNPLANLPLLNPNPPDFVPTGRYTQERKDFINTVHDSAFIWPEEMKAIHHLMMLHERAFAWSEEEKGQFNPKYFPPVEFPVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J474</accession>
    <name>A0AA38J474_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_739151</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J474"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3719558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="530" mass="61089" checksum="3F6088B8A088577A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4R5</accession>
    <name>A0AA38J4R5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine carboxypeptidase S28-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1006069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4R5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3718059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="487" mass="54255" checksum="1CA85A0C7D468378" modified="2024-01-24" version="1">MQKPVISRNGTQLPPYNTTYYFVQLIDHSDPSKGTFEQRFWHTYEFYEAGILTVLHTGPVIFFTPGEENAFQYIGYLTNVTFNGLLSQAQNGTTIVLEHRFFGLSNPLPSLTGENLRYLTLQQSIDDIEYFVKNVNLPMPGGNHLDAPWIMVGGSYSGALTSYTMDNKPGLFYAGYASSAPVQAMYDYWGYFEPIRENMPANCSADVEAVIEHITEVFEGGNMTAIQEIKDTFGMGNVQHLDDVAGVRSNLWDWQDMQPTTGPGAAFYNFCDALEVKNGTVASAGGWGLDYALAAWGAYWRSSYLETMCGGEDRRECLDSYDSTATYFTNTTIDNPYRSWNWILCNELSFSQSSPPTGIPALVSRIVQPEYDIRQCYYWYSDVFNAQNAPPMANGAAALSDQRYGGWNVSVDHLFFANGKRDPWREGTVSADGLNIPSTASQPILVSDGFHASDLIVDFGEADPSVGAVQKRALEVFATWLSEWKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J591</accession>
    <name>A0AA38J591_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1162025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000131">
        <property type="protein sequence ID" value="KAJ3710876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J591"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3710876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="481" mass="53694" checksum="75E5CB4808767FC3" modified="2024-01-24" version="1">MKGMRRDLRRAGYRSEHLVRQVETEILEWLDAGGVTINPDLVDSINYSAATGRPVADTGSIFEVFRTPQQLIWRIPDDAFARYVVHCCARYHTVVSFSKEAAGSRFTYLLRPNVTRPDRQAASSLDTPPTTDLDASSRFDSDTDFGSSVFADSDVESQPTAASHDDDNLSDIDEVSLSNGEISEAEHALTSPFNSLSLREGVDDPDRTLEAIPTRILRQTGASNRWQFQRSSSSPSRSPNPTSSLCCIQSPPLPTTSKNIIFPARFLKMLYQVFPLGRSSSLSLILIIALFSIAAVVATPIAPYDHHWLQPRSPKTVTNLKVWLGRYNIQEDKWDSKAAGYQPFGIQTLSVCFSLDPCFAVTPTGTSNDLVTFSVEVPNPSSRKQKIFWNLRGTASFYHDRKHDPENRKRPEKESVYDVLKDVSKLQASLQELGVHVTITDDVTYVTGVLKYAAVQPDRRQMSEGQEGDEGDECEKDNEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5X8</accession>
    <name>A0AA38J5X8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_142177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000139">
        <property type="protein sequence ID" value="KAJ3710354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5X8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="170"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3710354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="345" mass="38614" checksum="9BBE8AE4879C2D74" modified="2024-01-24" version="1">MAVEITIDNSLGALFIGLIIASVLNGVTYSQAWFYFSAQSREHSDPQWLKLTVVTVVSIDLLHQLFTSQWLYYYCVTNFSNEAALNTIPWSYYGMGVPMGVNTIIVQTFYIWRVWKLSKSLILPGVLWSVCLAQFGLLLYYVYRVSGLTSAAEFSTVMGPYAIATNGTGTAADILIAAAMVYLLQQARSSIKRTNNVLRSVTIFTVTTGILTSVCAIFVLAMAAAYPGTNIEVTFYFILARLYSNSFLATLNVRDHMRDRSHSGGVITTSDFQVHPRTNHSAVLTTASHELDNFPRQKTQMDDRSGDLETVISVKVDRITDRDYKHLQSLRTLPSYPPLKDSRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6C5</accession>
    <name>A0AA38J6C5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1004006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6C5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="99"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="473" mass="50230" checksum="A2F63430E4C513EC" modified="2024-01-24" version="1">MTTKALYPGAPAETRPSLLPKLAIKPWIPGPPPSIRLINALVVDPASGSLLGSNSNQTVLKHTVVMNNGKFVEVRPTVKEDENPSDKEEVMVVDLKGAYICPGLIDCHVHVTAVAGVKTMSELMRVSAQEVHLRTTYNLKEMLQRGFTTVRDTGGATKVLANAIQEGLIVGPRLFQCGKALSQTGGHGDFAPALSGGHELGCCGGGDVGLFARVADGVPAVLSAVRGELKGGADFIKIMIGGGVASETDAIESVQYTAEEIRAITTTCKQMGGKRTTAHAYTVESIRHAIENGVQGIEHGNLIDEPTANLMATNGIYLTPTLSCYSIMTRPPFENFLPPSGQAKNEEVMKQGLKALKIASKAGVTICYGSDLLTSMQALQTEEFTVRATVLSSPEILRHATTNAAKMLNKADLLGTIAPEAYADLLILNANPLEDVTVLDRPEEHLIAVIQEGRVVATSDPSGLLESFEGLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8B8</accession>
    <name>A0AA38J8B8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1099986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8B8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="331" mass="37220" checksum="E0729C2A7857C8BA" modified="2024-01-24" version="1">MPVDVEEDEPDVQLGVEDTELNELGDSEFPLYFTERNNRLYQADTATSPYPLPVDTPENQRVNALHKALYQLIGRANYIGPVTEVLAPQEGPRKIAIDLGCGTGQWVMEMAREFPHVFFFGLDVVPIATRYPEDNVQFELHDIGEPMRWPNGSVDLIHARSIFMTVRDYSVIISEAARLLKSGGMFLSGEWGPFPAFHPTFPQAMGDPRDYVPGLDRFYRLLHSVLATRGIIHAVASTVHQRLDASGAFTDIHEHIFYMPIGTWSPDPGTQILGKRNRAALTKFMNSIRPIFVAAGESEADLEQLYNECWTEMYGASGLVSVYYLVPARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8I0</accession>
    <name>A0AA38J8I0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1161698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000116">
        <property type="protein sequence ID" value="KAJ3711667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8I0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3711667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="102" mass="11637" checksum="87C45F0BAB2AFD20" modified="2024-01-24" version="1">MRPSIIRASEMPGPKRAWGSWWGDPLIKQKGIIQYTLAPNQTKAGPHWIRSYIFNFYRRVSAEAVYFVIPFGLGYGIYTWAKRRDAYQNSKAGHIASGAAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8N4</accession>
    <name>A0AA38J8N4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1187166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="211"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="927"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="964"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1312" mass="140939" checksum="EAFD55CFDD6FD2CD" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9U8</accession>
    <name>A0AA38J9U8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_877412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9U8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="287" mass="30033" checksum="9A0420945F78EFE8" modified="2024-01-24" version="1">MGSVSMQQFGPSPSPFGSSLNMGSVNSMGAFSTPPHQVGEGLCMSPPPSSYNGRASTITGITRYDSPSPSVQFMARSQSPDSSFGHEMSVQPFLLPLTQPSLVAVTKSGSAGAGAAGAGAGAVYEGPSSQRNSQDSLLSPRPRRMNPPAYDDAIANSGLSELPDSRDVAAQRRETYGTGHNAVRLPVNEKSQHMQVQSSQDSSIVGPDLAAIDAYVSRMATNAPRAGDQGGSDTVPMFHTTAVTPPRTEQTRPEVPQRRFTVKTMNTTMDDGANASVVGDRESLTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA42</accession>
    <name>A0AA38JA42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1072384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA42"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="296" mass="31896" checksum="3CC38AA7C227E3E3" modified="2024-01-24" version="1">MPWSPVKLNSGHEMPTIAFGTWKLGNGDGPINQVDQAISVGFSHVDTAQAYRNEPEAGKAIRDSGLKRSEIFITTKYSGLNGLDIKTSIKNSLENLGVSYVDLYLIHHPRLAVPDIPSAWKEMEKLVEQGVVKSIGVSNFGVNDLAVLLASSKIPPAVNQILLHPYVYATQAPIIEYAKKHKIIIEAYSALIPLTQRPGGPVDVPVKELSKKLNVAPEQVLLAWVKAKGAVAVTTSSKKDRLERYLDAGDIFLADEEIIAIDAAGAAGSMNAARKLQAGILIFAVCVALTIVGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAH7</accession>
    <name>A0AA38JAH7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1070270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAH7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="966" mass="105241" checksum="590B54DE874E6A5D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAX9</accession>
    <name>A0AA38JAX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_640393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAX9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="281" mass="31423" checksum="38DD62000FF645AF" modified="2024-01-24" version="1">MDLLFSSSPVQYPYSPSTPSSNRIKSYSLSRSNHKPLNSSPLAGNSSPMSSPVAEAQARRQSQYKSRVSSGPQRSRPGFAPNSGLMSRVAGSSSAGGTDSQNAMLRDRFKQRCLERAEKARAKAHAAKRRSGPDSDVFDAMDDDIEEDDEDVIQGEFYQRIMMNQARQQRHAYLRSYYAEVGSSFDPDLEDAAAWERELHAPEPSQAGQFSDQDIQETVEMTPEELEQAELEAYAEECERRAALADFEDIPFDELFDDEEVNESLAEGEQSHNGDDDMDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB97</accession>
    <name>A0AA38JB97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1006508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3717214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="546" mass="62551" checksum="A8D3B234C31586EE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBE1</accession>
    <name>A0AA38JBE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1126249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000073">
        <property type="protein sequence ID" value="KAJ3717593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBE1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3717593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="272" mass="30602" checksum="E7AC81F66A966966" modified="2024-01-24" version="1">MGQSVSSSTGGAQFPVDHASLKSASCPVDHDSLKSSSQSPAQCPVDHKALHSSSSSQAPAECPVDHSSLNQMPTLSQGRTPNQVLDLPTARTESSILRDSSTKWDYPSPQQFYNALVRKGWETPEEHIETMVEIHNFLNEQAWQEVLKWEKRVTDNPSGIQLARFKGRPGEISPKARFWLLAGWLLPSRFNTEPPFDRHDWIVRRPNTGEEVRYVIDYYSAPPEPNGSPVFSLDVRPALDSFASVKERIAFATEEAWAEFRENRSTEIPKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBU4</accession>
    <name>A0AA38JBU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_563509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3726367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="214" mass="23919" checksum="3FF08F3300FFFF3B" modified="2024-01-24" version="1">MLIDISTVSECAYHDGMHQFDTDLFCVQMLVVKQARKHVGSLLATQTFNSELYTDSFRRGCIRSNSSNSASFTKTYVREPILNTGARRSLTHVFSIHWQPGPRRLPPVLAIDPVDDRQGIVSLSKHRISGAATHFRNTGAHVINPGAPLQCTVCRRKRRAPPTSIPVHSPESFGRKHCNPDICYIWVHNFAYILSALELPFLSTVANPCVILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBV4</accession>
    <name>A0AA38JBV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_349984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBV4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="291" mass="32117" checksum="2A2643163EC0A759" modified="2024-01-24" version="1">MRNYTFLILAIFAFRSQDAISYPLNQSFALLKTRRFEFSPLFGQVTYGNTQTNLLPSITTGTGKLNPTASSGTSLSAGGTASHRSGSSMSTISEDDGTHSIIGTLPPIPTNSSISPVATTTNQVSLSTFSPYSEPTVSPTNNINSLSSISIHEEKQWKVIGIGLIVIAFIASMILLTVFFEAWWGFLRDLCGGKEYRGGVEEMIPDSEDKKWQLNLSNEDGHRYPSASSMESIINQTHKPKSSYPYISTPKPLFQPPSYFRPHYDPHPLEPLFRRPSVKTAVIKSPIQLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC48</accession>
    <name>A0AA38JC48_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1182551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC48"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041323994" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="30"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="555"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1045" mass="113226" checksum="1B1554B147D2C39C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC94</accession>
    <name>A0AA38JC94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1152396</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC94"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="81"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3734197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="490" mass="52821" checksum="4B1E41043B5CD07A" modified="2024-01-24" version="1">MDIGAGITTGTAELREATKMERIGVHSHITGLGLDDRLEPRPNSQGMVGQMRARKAAGVILRMLSPSSFSSSTVSAAPGLSGRAILLAGPPSTGKTAIARGMAATLGPDVPFTSITASEVYSLSMSKTEALTQALRRSIGVRIREEEEVVEGEVVEIVVERGITGSGKSGRVILKTTDMETVYEMGGKMIDEMTKEKVLAGDIISITKSSGRITKLGRSFSHSRDFSLLSPSTTFIPTPSGEILTRRTITHTVSLHEIDIINSRTQGFLALFAGDTGEVAAPLRAQIDVKVGEWREEGKAELVTGVLFIDEVHMLDMECFSFLNRALEGELAPLVVMASNRGVARIRGTEMRGPHGLPPDLLDRLLIVATSKYDAEEVRQIIKIRCQEEDVEVGPDAEDLLVEIAGDAGMRYALGLIAVSQIVARKRVKSSGGGSEAVEVEDLRRAYGCFMDPGRSVQWLKEQQGSLLVEEITVSENVRQGQSSDKMDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCP8</accession>
    <name>A0AA38JCP8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1093928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCP8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="99392" checksum="3E1BF42B4274139B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDE1</accession>
    <name>A0AA38JDE1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1092895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDE1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="732"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3722721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="818" mass="90035" checksum="0630AFB442B7BB0F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDN0</accession>
    <name>A0AA38JDN0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">THO complex subunit 1 transcription elongation factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1091763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDN0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3723599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="951" mass="104802" checksum="FC073AC40A8050A0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDZ6</accession>
    <name>A0AA38JDZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1029657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDZ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3725001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="581" mass="61881" checksum="401461DF8B0E5310" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE15</accession>
    <name>A0AA38JE15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1160504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE15"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="489"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3715298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="750" mass="82075" checksum="5EF84F20EE3E8564" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE62</accession>
    <name>A0AA38JE62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNF2 family DNA-dependent ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_992801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="722"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1281"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1322"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1454"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1322"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1456"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1630" mass="184981" checksum="37C6A960CB6C47E8" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEI2</accession>
    <name>A0AA38JEI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1141834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEI2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="388" mass="42899" checksum="3BE0979DE894384A" modified="2024-01-24" version="1">MTLIVHYVLAISRSVRFCAPASYCWLPLYLDWIRLHSRQSATRTRRCIIPTTFPNSIPTKRPPLTIPLNIEMAVGLAKLDLVSVFVECVLYGFFALLAIIAFSIVLQRRRIKHQKPRGTLRILFAVLVMFLLATVHLSVHFHRTLYAFFGPGSSNTTTEKINSIGKVDGILVSIGSVGYTLKTTSYYLQTYIYRVYVVWSGNTKVMVPLIVSFLASIGLSIYVLQEMGQAAHGDTIFESRLYDSILSFFVVTLFTNLGSTILIAGRIHWLHSQVKDASRVFVSCPLFGTSARAGCSAIFVATVISESAAIYSATLVVILILYALKIHIVYVLIDAATQLIGIVFAFVVIRVAIGVSTEATPPVRPVDEPDSSVSLSEIEDKSIILEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEW9</accession>
    <name>A0AA38JEW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_796370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEW9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="73229" checksum="CB57633299676BBD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF19</accession>
    <name>A0AA38JF19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_785192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF19"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3718056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="728" mass="81032" checksum="864B9F8397FF9D62" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFA8</accession>
    <name>A0AA38JFA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1130336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFA8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="2">
        <location>
            <begin position="173"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="3">
        <location>
            <begin position="635"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123454" checksum="A3725CDC0EBEAE91" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFC9</accession>
    <name>A0AA38JFC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1066600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFC9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045379">
        <property type="entry name" value="Crinkler_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20147">
        <property type="entry name" value="Crinkler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Crinkler effector protein N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3733749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="133" mass="14955" checksum="1D191B1338E92C6F" modified="2024-01-24" version="1">MTFEFNCLVLDSHPSIFAVQISETDTVATLKEKIKEKTRPTFDHIAAHTLDLWNVSVPIEGLSDTHLHDLQPVQAPLLPVKRLSRLFPNTPPEEYLHIIVRPPAVAGASSTFFVSFNISYSLQHLQIHSPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGD1</accession>
    <name>A0AA38JGD1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1158568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGD1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3721387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="220" mass="25652" checksum="700A0DB884ECC7E7" modified="2024-01-24" version="1">MSWTTHQLATSDDTNGSDFHAVIDTDVFTCLSCRPHDFPRVPSRSDTVNPSPNAATLPNFYTPRWVTSSLPFLGFAPSSNPFKFYFLKCLDYDFHTLPIEQISENRYALKQSLQTDWDSLERNMRAFLRGCMKVNRLNIPEDFWLWPYPNFYMYHAVWRTEVDARRAAMRSRQAFIPLIACISFYLRLLYHLESKWVDIVAASSCYDHARVVGDKLDRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGV2</accession>
    <name>A0AA38JGV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="358" mass="40314" checksum="BF8083F706DA262F" modified="2024-01-24" version="1">MALQDARLRLYEDQFILYTSPPKLALGELGEPDDLGWQWFQCTDILQILLPPDISIRYNIFLKMERKSSKLASSHTAVRRFNCTRKAFVDQCLHSKPEYPVRGISPSMYRYALEPGFRCSAIDDTIAREEFLADSRCLSTFDTHLVARSQLGLLGPTNEWGCSWVRLREDTQVLLTADTTSQYHAFLRWSILSDTRHTGWEATIDNFTGACLDHAYYLGTYKRDKLYVLERDMSGPVLASITGASRAHYNGIAEKARLYAQFAPTNPSFGGHYPRRSNFPVLGRHPKRKSRGKYRPVLGPLAETQEDAVAPDSDANPNESGWKSSSQFSASTTVLCTSTSTESESVKDCKVLIVQNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH60</accession>
    <name>A0AA38JH60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1054958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH60"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="288"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="821" mass="87983" checksum="0944FF0EF952CB31" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHH5</accession>
    <name>A0AA38JHH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1099683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3717292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="552" mass="58814" checksum="AA070AB94A676414" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHP9</accession>
    <name>A0AA38JHP9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_321253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHP9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="197" mass="22459" checksum="3E6070F26F80789B" modified="2024-01-24" version="1">MVHILGINLPDDQLARFALTSIYGVGPHLSHRLCARFQIHDKCRVRDLTPFQTTALSSFLQSPKTALPVAQYPLAPINFIPRPPSKSIQELQAELNAERAAQKQKRDEKLQKMGKLPVEDVKAKVGGRKAPEKKSRDPLTELRIESELRREIRENIAHQRLIGSYVGRRHAMHLPVRGQRTQTNAKTARKLNSLDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHZ7</accession>
    <name>A0AA38JHZ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1081104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHZ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3731015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="160" mass="17914" checksum="570AF98D5C4C9D9A" modified="2024-01-24" version="1">MVRFKNRWLLVEFLPIPSTPQSGAVAQTIQLNLDGRQIHSVLKQSILSNYGDIGWGAVALSLSVKYFSPTTNICIIRVGREQHKIVWGALTLLDGLEYMRLIPHVVHVSGTIKHVQLAAIAHNRTVIARYRAMANAPVAYQDSYDAYLESSNRDIESLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI71</accession>
    <name>A0AA38JI71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1058403</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI71"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041340218" description="laccase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="161"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="362"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3735579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="523" mass="55526" checksum="B3D915B38EB9C535" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIS2</accession>
    <name>A0AA38JIS2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_517727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIS2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="179" mass="19280" checksum="7E46C174296C9FA5" modified="2024-01-24" version="1">MASFLRKFTTAASSISTGSNVFFDVAIQGQPAGRIVFKLYDDIVPRTARNFRELATGQNGFGYAGSSFHRVIPSFMLQGGDFTNHNGTGGKSIYGPKFNDENFTIKHTRPGLLSMANAGPNTNGSQFFITTVVTSWLDGRHVVFGEVVEGMDLVKKIEGEGSQSGRVNSKVTITESGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ42</accession>
    <name>A0AA38JJ42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1078478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ42"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041216424" evidence="1">
        <location>
            <begin position="18"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="549" mass="62507" checksum="84AD811D06C1AB6E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJP0</accession>
    <name>A0AA38JJP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1199929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJP0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59124" checksum="468FC042615AAF16" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK61</accession>
    <name>A0AA38JK61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_988791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK61"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18175" checksum="29C76EBC392EA439" modified="2024-01-24" version="1" fragment="single">SVVDYRGSILLDTFVRPTHHVHSLRFLETNIQLSDVANAPVFDEVRNRVASLVQSKIIVGHSLWVFLSIMGLSHSTLETRDLALFRPLRRKLHSSRIVDLPTLVHIYMGRKIGLGTEDSLENARACIDLFRSCEVQFEDVVHVGAWPCDLPPTSYSQYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK84</accession>
    <name>A0AA38JK84_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_997313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK84"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22753" checksum="E712B15A140BF6BD" modified="2024-01-24" version="1">MSSIEMDDLSIRSNKKEIPNDEGNEETQDLPEVEKNEAISAWTMMAASLLTVLAAIFSLFPQLLLFLSTDTPSALTSLERFLSLHFGIWLFTIAVALVLNIPSTSPLPLGLSQPDHPLLKPFSFACLLSSFISYNTRSVGSLATIHCFLTAIVGLWGLWAMVFGSSVRVSRKTGADKHTSAFIFGNKSAASKQKKEWLRQQKDGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKB8</accession>
    <name>A0AA38JKB8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA polymerase mu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1220035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKB8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="7">
        <location>
            <begin position="210"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="610" mass="69150" checksum="DF2A67E7E93F9188" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMJ0</accession>
    <name>A0AA38JMJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_558530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMJ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3726506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="479" mass="51837" checksum="8293F930837AD3CE" modified="2024-01-24" version="1">MLPKLIHRSGRPLGHTLVRHGNRYVSGSSLRSPAALNDFGKHHVTKGLARISEGVMARGQGSYVEYLDGKKLLDFTCGIGVTNLGHSHPKVSKAAADQCMSIVHVQCSIAFHEPYLRLIEKLLPAMPHPSLDSFFFWNSGSEAVEGAIKMARILTGRQNIITMQGAYHGRTFGAMAVTKSKTVYSDGVAPLMPGVFSIPYPFWHQHRLPPSTPPSVLTEECLYQLHLLLSQQTSPKDTAAIIVEPVLGEGGYVPAPKEFLEGLRAVCDQHGILLIVDEVQSGFGRTGNWFFIEESGVKPDILLMAKGLANGFPLSGVVSRKELTDKLVPGSMGGTYAGNAVSCAAACAVADAFQEENIMANVEARSQQLFASLNALKDDQTLAQYILDVRGRGLMVAMEFASSEAPGAAFDPATPKGLTVKKGIASRVAKKCIEKGMLLLTTSVYEVVRFIPPLNISQEDMKKGCEIFAESLREVVRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMU7</accession>
    <name>A0AA38JMU7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_996819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMU7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="360"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="917" mass="101920" checksum="D9019E623B2511E6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNA4</accession>
    <name>A0AA38JNA4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_39538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNA4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="461"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="364"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="601" mass="66768" checksum="1A1C2E5CCB733EAD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNH4</accession>
    <name>A0AA38JNH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_290194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNH4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="235"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="486"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="879"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="900"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="962"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="972" mass="108459" checksum="DA0B2672CDAE0906" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNM7</accession>
    <name>A0AA38JNM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1153389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNM7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3733360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="507" mass="57508" checksum="58F6BCF7B987B8D5" modified="2024-01-24" version="1">MPTHSLSALSQALALGAIFLTTLLIPKILQWRTRMMKLNAIPTVGSPGFFTSYISARAFKTDARKIILEGYHKYPGQAFKVPLPDRWEIIVSGKEMMEDIKKANPLDLSFIEAITETMQSDHTLGKPARVDTYQIDVVRTPSREIWESNSKICEMKSKMRLQMKFLPKVPMLYTVMKIVSRTSNRYFVGLPLCRDPDYIRLNIEFTIDAFNGAKTLQHYPNILKPIVRQFLTDVPTCLKRATKHLEPLIRERLRKEEEYGSSDWPDKPNDLISWLLDEAQGERRKDIIYNIVSRVLLINFAAIHTTSMTFTNAIFCLAANPHLAQPLREEIELVVSEFGWTKAAMGKMWKLDSFLKETQRLTGIGGLTMTRLALRDFTFSNGTVVPAGTIVSVASYGMHHDNVLYEEPDTLNAFRFSELREKEGESLKHQMVGIDSSFVLFGGGRHMCPGRFFAVNELKALIGEVLVTYDIKFENDGGFPAPDWNGASASPNRLAQVMFRKRIPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNW1</accession>
    <name>A0AA38JNW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1113415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNW1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="12"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="251"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="275"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3735732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="414" mass="45423" checksum="11DEB871FCC2636B" modified="2024-01-24" version="1">MEFKVTHRCHTTRARVSRMVLAHGETVLPTFMPVATQAAIKGLTPEQVESLGITLILNNTYHLNLRPGVDVLKAAGGAHLFEGWRHNMLTDSGGFQLVSLSKFTTITEKGALFSSPFTGESTILTPEESISIQHAIGADIIMQLDDVVPSLLQGPRVEEAMERSIRWLDRCIQQHESSGQKHTQNLFAIVQGGLNPSLRDKCLDGMLERKDRVSGYAIGGLSGGEEKDVFWRIIKQCADKLPEDRPRYAMGIGFAEDLLVCVALGIDMADCVFPTRTARFGVALTHTGPMNLKLGKYAKDFDTIDSMCPCLTCRDGTSRALLHHIVTHETAAAHALTIHNIVFQAQVMGRARDAIIAGTFPDYLRSFFANYFGDRGYPEWCVAALRSVGVDLLENSDIPMVSGGGAKWEYSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPW0</accession>
    <name>A0AA38JPW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="12" type="ORF">DFJ43DRAFT_693359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPW0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="137"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="373"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="140"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3736009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="494" mass="53428" checksum="1DEF9A1B0E5C6145" modified="2024-01-24" version="1">MSEENTAKEWILDAETEYRFELDAGTSLAITLVRGRAEIFGAELVERKPYLFGSECKAAVFTWVGCTIEVTGSPSTEYVSDETPMSAYGNLHIAFEQMRVKALAKLHGSPVPEYAHPTQSKTQSDFSAEPPRVLILGPENSGKTTICKILVNYAVRAGQGWSPILANVDPNEGGWACPGALSAAAIHGPIPTCSPANPLGSAATSAPATLSSNAILPLVYWYGHAEMKRNSLLMDRLIRNLGINVQEKFDQDPEGYTAGIIVDTPSSFASSSGLGVNDHRQKLIRACIDAFRINIILVVGHEKLNVEMQRSYGSLLTVLKIPKSGGVVELDHGYRERIHKYQMHAYMYGEMIPSPPGIKGGTQGGDTLTDFILTPSSNVINFSDLTIYRIGAETMAPSSALPIGATRVVSEMQPVLVDPAQPGSGLLNAVLAVLAPYHPDENERYDEELLDLTVLGFIVVTNLDIPHKKMTVLSPTQGSLVGKTAIVGSYEWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQA3</accession>
    <name>A0AA38JQA3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1067929</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQA3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3733596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="160" mass="16405" checksum="C6F13DBCDCBA0C78" modified="2024-01-24" version="1">MASADHTRDPCPWVILNDFGGAFSMGAVGGGIWYSIKGARNSPRGERFVGAMSSMKARAPVTGGNFGIWGGMFSTFDCAIKGIRQKEDAFNAIASGFLTGGCLAARSGPRSALGSAVACGILLGVFEGVGVLLSRVFAEGQRPPLPAPMSAQPTSSAPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQE8</accession>
    <name>A0AA38JQE8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_511951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQE8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="102" mass="11033" checksum="D6873A6BCA5FEC2C" modified="2024-01-24" version="1">MKVPTFTLQAQEICITSAAVAPSLLSATYLSTHKLFYDGPTPPDGIFDDFLAIPFFTKDVSTRDFVSLVQSSPSNATAGTRAIFDSAPLLELTPTVLECHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQF9</accession>
    <name>A0AA38JQF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_186816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQF9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1093" mass="119905" checksum="6A6F895E796E5020" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQK1</accession>
    <name>A0AA38JQK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Triose-phosphate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1131146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQK1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="58"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="442" mass="49755" checksum="AFBE2BF0F7F9504B" modified="2024-01-24" version="1">MARPHQDDRSLDDTLINSMQPREDYYDQEAARSSPYGHILSVDEKRKLWIQNATVNMMFIGSWFFFAILLSMYNKWMFSDSHFNFPYPLFVTSLHMVVQFLLAGLVLNIWPHKFKPERYPTMEEYGKKAFPTGATTSLDIGFSNLSLKTVTLSFYTMVKSSSLIFVLLFAFLFHLERFSWRLVGVILLICSGVLLMVATETHFVLGGFILVISASALGGLRWALTQTLFQSKKMGFSNPASTIFLLSPVMAVTLIVLSFFVESWSSLFGSEFFSSGLTRTIQTILLLLAPGVLAFCMVLSEFYIIQRAGMVPMSIAGIAKEVATISISAWFFGDELTPLNITGVAITICGICLFTYHKYLKSIQSTVPLDGHGNPILSEEEAALHSGDDFVELDETSRLASQSRDDLQIHQIDQSRSQMLFSAEDEEDDERERHPGLSQGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQU8</accession>
    <name>A0AA38JQU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_989281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQU8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF67">
        <property type="entry name" value="SCF E3 UBIQUITIN LIGASE COMPLEX F-BOX PROTEIN POF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="211"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="387"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="875"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="99549" checksum="8341AD349E534A34" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR34</accession>
    <name>A0AA38JR34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide exchange factor Vps9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1060114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR34"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="394"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="843"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="96880" checksum="244E42FD59287D2D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSV3</accession>
    <name>A0AA38JSV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1154509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="531" mass="60448" checksum="930B8127DBCAA245" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT33</accession>
    <name>A0AA38JT33_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_306270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT33"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="334" mass="36883" checksum="4705032E429AF011" modified="2024-01-24" version="1">MSDAIDNSLVTQLQENIITCSIGGIFFGIYVVLAIVAAYILLQQGLRQSLARSVLFALNVVIFIGQTGNLVAIIVSELKIMQSLGEILYDPTQALEHWEVAIVVFSRMNYLISDAIVIWRAWVLYDDRLYLRILLILCGLGSTIGVALDSAFVLKQAFSNGTGEATALTRIRVLMPVMLLITNIIATAIIALKVWEYRRSIKINLGKQTRKTSVERVLVLLLESGVVYCVCWIVSIISLTPGTLSFIGENVFATMLPNLTAIYPTLIIIFVAARRSYSELSINVSQTLQFAIPTSPYIVSQTSEPEARRPSFVAPKAAGIRQVELERHVSDESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTW4</accession>
    <name>A0AA38JTW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophobic surface binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_281141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTW4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041286164" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="185" mass="18348" checksum="29779667157F60D8" modified="2024-01-24" version="1">MTRIASFTTLLTFVTACLAAIPLKRDVSTVEQDIANIASQVTALDSAINAFPPSGGSLLSALAIHTEATSLASALGTAATDVAATAPFSDADAATILASVEGFEPTILDALTGIVAKKPAFDALPLGGVSALVAADLATLSTNTKNFENALIADTPADLLAQATPITSTIDVALATASAAYAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU42</accession>
    <name>A0AA38JU42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_990332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU42"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="578" mass="63436" checksum="E6108DC44AF350E2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JX52</accession>
    <name>A0AA38JX52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Electron transfer protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_993048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JX52"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3734408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="502" mass="55024" checksum="EEAE23E7C11DD7BB" modified="2024-01-24" version="1">MLPSCLRAKFSLQTTYKWSRTLWSHDGVKAFTNSSPSFRTNTLSALPRSPFSNTFKSSFSSSSTRFSARNTKNDTLAAEKRFFSTNNSQSGGSATLPILPPKSVGIWLMASSTLVLAIIVVGGITRLTESGLSITEWKPVTGIIPPISQAQWEEEFEKYRATPEFKLLNHSFQIEDFKRIFYMEWGHRVLGRLIGVAFVGPLLYFAVKKRISKPLATRLGGLALLIGAQGGLGWYMVKSGLDDALMETPGAVPRVSQYRLAAHLGLALLLYAGMFSSGLAIVKEWKYATGAKWMGLTTSAFNEALNSPAVMKFKARSWVLTGLIFLTALSGAFVAGLDAGLLYNEFPLMGGRLAPPRDELMSPAYAKRADGSDKWWRNIFENPTTVQFDHRVLAMTSYLGTTFLFLRARSMRAILPPLTRTAVTAAFAVVNVQLLLGITTLLHLVPVPLAAAHQAGSVMVLSAMIHILLTLRKPGAAARAWRALHMQRLNGGTKTQTKSTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYP1</accession>
    <name>A0AA38JYP1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_991655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYP1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="906"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="941"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="706"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121278" checksum="8A32690724A6856E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS92</accession>
    <name>A0AA38MS92_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1002708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS92"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3725002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="90" mass="10019" checksum="615062C660D72C7E" modified="2024-01-24" version="1">MSSFNAISLFWSGSHSIYVLLMAYGASTATTTLPCIFYILKEHSNMTTSQQLILLSSYIPFFVVPLLMAIDMGLRLYSIVLSADSKQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MT66</accession>
    <name>A0AA38MT66_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_999357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MT66"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="257" mass="28335" checksum="5BC00D2CC7F68D15" modified="2024-01-24" version="1">MLYLVWNKELLNIGGAVARAAYELEMDIIKQMSDSAGSTKTAEMQSWLMDRAIHVLKFFTFHQSTPSADVSSLMEQAFFTSSAGFRIISTNGIHDVADIRLPDGQFSSFLKDLPVLPEELLTAARPMVTAMQNRKLIKAITFSDVLKELSNRPLTEEESIACLTWWTSLNKDGESAARLNSIRQQLLDAAVFTTGAAGSDTERIVPLNTIQSILNPRGMAGNIPSDAPFPATMLPPSISKSFKPDQLTFAFRRGPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTH3</accession>
    <name>A0AA38MTH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1077387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTH3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="204" mass="22983" checksum="B3C376814E37DA45" modified="2024-01-24" version="1">MSHLPEFLRPLILSGPSGVGKSTLLQRLFAEFPDKFGFSVSHTTRAPRPGEQDGKQYHFVTREKFLALRQEGAFIESAEFSGNFYGTSFQTVREVQDKGRRCILDIEAQGVRQIKATDLNPIYCFISPPSLTSLRERLRARGTETEASIQKRLATALNEIQYAKEPHVHNFVIVNDDLDRAYQLFKQIALGEAVSGDKLPPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTS7</accession>
    <name>A0AA38MTS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_976910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTS7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="158" mass="18473" checksum="97545BC7B0F36A24" modified="2024-01-24" version="1" fragment="single">RLLHVSFKTQRHLVGPPDPISHLRPIIYDDVPPPPVPAVVNHPYSLQEFDPEPARNLNAYEMQWRLQRQQLDDLSQNFWLDSNARSESAKEAVLASLPAASTPMDRENALSEFYKQWLLQESERVDEYSKIWRSRNWANIILAARVTYSRFPSRITDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUL0</accession>
    <name>A0AA38MUL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1135030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000108">
        <property type="protein sequence ID" value="KAJ3712536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUL0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="579"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3712536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="958" mass="106466" checksum="04A360E332D641F3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUP4</accession>
    <name>A0AA38MUP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_45278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000100">
        <property type="protein sequence ID" value="KAJ3713258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUP4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3713258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="288" mass="32523" checksum="77E7E3E3AA195BEF" modified="2024-01-24" version="1">MIPETYTRTIEADGVHVFYREAGRTNTPVVLLLHGFPSSSFQYRNLITILAGRYRVVAPDLPGFGFTKVPESRKYRYTFDNIAKTIEAFVDVLGLEKYAIYIFDYGAPTGLRLALSRPSAITAIISQNGNAFEAGLGKFWEGIRKYWKEPTPANRQSLVWLTEFNTTKSQYEAGETHPETLPPETYHLDQALMDRPGNADIQLDLCLDYQANVALYPSFHDYFRKYQPPLLAIWGKNDSIFIPDGAEAFKTVLPKAKVHFVNGGHFALENHLDEIASEMIGFLETNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUS0</accession>
    <name>A0AA38MUS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1131246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUS0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="7">
        <location>
            <begin position="230"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="604" mass="66158" checksum="772D700BACFF7FE6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUW6</accession>
    <name>A0AA38MUW6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1007991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000094">
        <property type="protein sequence ID" value="KAJ3713994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUW6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3713994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="355" mass="37962" checksum="864190B6636ED3A9" modified="2024-01-24" version="1">MSLAYTTEKQFTISAVRRACLVTSSVFNKLVKNETLVKGDKSPVTVGDYSAQAVISSMLHRAFPNDSIVGEEDAADLRAENGALLRNRIVELANEALSAELGIGDVPEWGIGPGSKQTADELLDAIDRGNYEGGRSGRMWTIDPIDGTKGFLRGEQYAVCLALIVDAQVQVGVLGCPNLPLDLSKPDGDKGCLFIAVKGQGAQQMKLNGADPIPLTMPPYSPSTFTFLESVEAAHSSHSTTSRISAILGLRQPPIRMDSQAKYGCLARGDGGAYLRMPTGVGYKEKIWDHATGSLLVTESGGIITDSRGHPLDFGLGRTLGENYGVIATEKDAHERLLSAVQEVVKQEQEEAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVL0</accession>
    <name>A0AA38MVL0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000098">
        <property type="protein sequence ID" value="KAJ3713500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVL0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="739" mass="84211" checksum="23ABF9835D5B0B83" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVU3</accession>
    <name>A0AA38MVU3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1151586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVU3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="271" mass="29445" checksum="FDCD9C60D0E0470F" modified="2024-01-24" version="1">MNGFPFDVNNSPLPYPGSVNVSLGSGLDSQIFTANDEFDFTSINYDEFDFSSINFDDPMLADAFNSLDYGNGMSGSNLGNSDTTAGSRVDTGVSALGHQDPPASTSNTPSNSILAPVLVPKTGFTSLEPTTHAQRNPLLPTQSICPHLKRTLDPVQARTMNEAKAEKQRLAMLARDDVLKLATEFEQNVAGLAEKHSVSVEYLKSLMSMASKFKCMRAPGRMQALVHLKAKEVNASLPVGGKLKAPALRKLHRIPGLTSERRRSWIILMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWA5</accession>
    <name>A0AA38MWA5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fruit-body specific protein a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_872976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWA5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041404497" description="Fruit-body specific protein a" evidence="1">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23464" checksum="B4B94A9A0DA9A31F" modified="2024-01-24" version="1">MLYIPLFVASLASTSAAIYLPPSNMVDSTELIVASLSASNHHGAPNPPDHAGSIPGWYYGNDPASADGLPWLKDSDLCATLASTHHTLRCPTIQKQPTKTYGKRSAEIAAPTQHSNFVAYDPTPSYYTVFSGLTGAINGPGYLTYGLVDTVDDCEAMCNSVSGCVFVNAYHDVNGKNGSPLLTCSLYSEVNGADQATNYGGQLQPDGSYDYVTDSDGYALNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX57</accession>
    <name>A0AA38MX57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_964365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX57"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6333" checksum="611A4519DDB80131" modified="2024-01-24" version="1" fragment="single">RYSILPALSLDGILHLDIQDWSFTTAFFNTFVDGLLNVMNPIPGKNSIVVMDNASIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX62</accession>
    <name>A0AA38MX62_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1093284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX62"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041416467" evidence="2">
        <location>
            <begin position="18"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="370" mass="37429" checksum="45161BAF9B380176" modified="2024-01-24" version="1">MLSIIATALAVLPAALATSWDVSVGPNGQLIYYPEYVLAEVGDTVNMIFHPKNHTVTQSSFDAPCVPLSGGVSSGFLPVASDSDPELPNFVITVNDTNPIWIHCEQKGHCGSGMVFAINPPDASSNHSFAAFQALAIELNGTQTSAISISTPPAQSWATATATVSDASSTWVSTYTSYSGTPEPTYAAGGPVTHNITVGINGQLAFGPANISAAIGDIVEFTFLAKNHSAVQSSFSEPCTPLADGFNLGFHPVDANTTGPTLSITVNNTSPIWGYCAQTNPVSHCGSGMVFSINAVESGANNFAAFLALAEATLANSTSEAASGGGTASASSPSSSSGSNGALSAVNLGGSIGVMGTVLAMIATVVVGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXJ8</accession>
    <name>A0AA38MXJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1088143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXJ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="459" mass="50253" checksum="C9C6E7B360DBBD58" modified="2024-01-24" version="1">MPSLTEQLASARQKDQQISASASPAPTNFQREPLGNSEQLNQLTPCPRSSLFSDGPHDGTFGLGSSGLVPTLDHASSPINPIPFPTWSSEGNNLISGLANDQSHDFDSQSQGNPFHLPGSQVVNMDLSPSFAAQLKSSANDLPLEMKEGLEQYIQSRTLAERLAMHYLSSLNTQSMIQQLIREKDTHWAVSGSLKKLIAKYAKAYMLSSTAKFYIKCNPEDIIVSALRANRVKDLPNEDDLTATDTLKSAVSRAVVQSRSTVKDHIMSTVRDTSKTSQLPADERDLGTVAQSLLGGLKDVPLSLALMYRLALMRNVADNNPDMNTRDFWPTVDSEMAALLGVSQEGIKTQQQVIADFQLTYELDVKKYGKHRVSPTNIGSSTYQWKTFVKTVNTLAGNATIIDSTEKKAERKRKRRINDTDARRTRSSAAADEGSDGEEDTTEDGVPGASGDNENEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXP6</accession>
    <name>A0AA38MXP6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXP6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="861" mass="91755" checksum="D6C60F6F786D57FE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXQ8</accession>
    <name>A0AA38MXQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_1086388</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXQ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="19">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="156"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="18">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="478"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="574"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="706"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="756"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="774"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3727337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="839" mass="94393" checksum="80726FBD994B5E40" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYI4</accession>
    <name>A0AA38MYI4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1190941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYI4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="279" mass="29807" checksum="CB5A1CB89ABB9251" modified="2024-01-24" version="1">MDGTLIDSSPAVAAAWKLLKETGYEFLDLDHILRSAHGYRTIDALRKWCKIKDEELLKREVVRFENAILSNAQAKAGSGGGIIALPGVSQFLDDIEASIDSQHATHFYASQALPAAGLRIPKVFVTAESVTQGKPAPDPYLLGAKLNNVSPFDCIVVEDAPTGIRSGKASGALVLATCTSHTRESLERESPDFLVPNLSYVKASRNPDGSVTLAIAQPADRKETAPTPDDTPLHTPALSRVPSATDIFKKIHSGVATPRESGTEIDDYGARGIKAMSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYK6</accession>
    <name>A0AA38MYK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1040632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYK6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3729933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="265" mass="27620" checksum="8B0CD8C4116EBC3D" modified="2024-01-24" version="1">MHAATYAAHVLNSAAGITAITTSPAPSGTYQQTNTIPTSQGYNNHRISPPTSRDRMDSNTHSSHNHTLASDNSPPLSASTTGSLKRRHTNEYPENSQQSPSLGGSSSGLPPGPGSQVLTQQPPLPPSSLPQQPGQQQQSFSHPQPPSQLQPGGVAASNLPLVQTEGQTCLGCNATSTPEWRRGPMGPRTLCNACGLVYAKLIKKRDRERARANGNGKNNGSSRPTSGEGHRSGSGGGDSGSGESDEDEPEDDYGSGTSGRRSEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYM8</accession>
    <name>A0AA38MYM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1002387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYM8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3725649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="329" mass="35250" checksum="D21CD83BBE9E72D3" modified="2024-01-24" version="1">MTAQSTTSKPPPPGVYVPAVLFFKPGSEDIDEEAYRKHILRLAEGGVTGILVQGSNGEAQHLSHEERSHNIVFVRKTLDEAGFKHVLIIAGTGAQSARETKELCVQAKESGAGWVLVLTPSTWAPAMGPDSISKFHREVADASPLPYMVYNFPTVTAGIDLDSDLLSSLATHPNIVGTKLSCGNMGKIQRLSSSFDYQSSFATFAGKSDVFLHTLISGGAGTIAALVNLVPKIHAKVYKLFLEYQKTKDAKVLEEAFALQAKLSAADWAVSKIGGVGGVKAIVAQEFGYGNLTVRGPLREANLGVLVQSEQGGKWWSAVEEVVRIEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYP3</accession>
    <name>A0AA38MYP3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1088116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYP3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3726410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="156" mass="17244" checksum="5EE0553B50620D27" modified="2024-01-24" version="1">MDVAFRKIDIDVYDEDALQESELYDADNRDPTQALEEVRARQVSVRSLLAKNDTAGALTTILDNPPYGPNVEDAKTISLQTLLTILNSTKSTEIPTAINSLSIDSQDTLMKYLYKGMAMSGWADSNASVLLSWHEKLTEIAGTGCIVRTMTDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYX2</accession>
    <name>A0AA38MYX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1225017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYX2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="49" mass="5356" checksum="87D4D3DE3D6E972F" modified="2024-01-24" version="1" fragment="single">RKPCGNSLSGIIIFCLILRTLYILTFDTHCVSLPAPIDNSIRSACTTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ46</accession>
    <name>A0AA38MZ46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IID, 31kD subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1000912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ46"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3729020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="256" mass="27649" checksum="AEC684E8FBA6C736" modified="2024-01-24" version="1">MSTTFRPADNLPPTARAIALILSSTPSVQDAQPGVLHQLLEFSTRYTQQVLTDAKVYADHAGRQDKLDVDDVVLAVQARVGWEFGGRVPSEYILSLATQTNATPLPPVPEVFGVRLPQSSDCLTSLDFDLIPNKPPPGVKIYDEEIEEIEESESEDEEMEPATIPDYAGSSANQSAPPESAQEAPFPISAIHMPSEADGDTRMGGENGSDAGEEEDGLFAGGDEDDSDGMEEVQTSLNEGAHNEIKRQLVETDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ52</accession>
    <name>A0AA38MZ52_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_503968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ52"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3728107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="70" mass="7786" checksum="E52AB6246389D190" modified="2024-01-24" version="1">MTRPAHAQAGRRFIKIMSTSRVYLWAILTARLVNTFSIVSRSILQTKAELGLCSVKPASRAPFPCQHTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZB2</accession>
    <name>A0AA38MZB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1039957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZB2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="194" mass="22240" checksum="61545E1319B1A75F" modified="2024-01-24" version="1">MTTHTSAPISNKVAPPNYLGQFLQLFIIQVSKLFVRCKNPKPAKCISEKMRDLKYLPSRQRTITGLPVEWLLRTIRKQHHPIIGPDGRTTTEESGRRAAFGNPLIDKSDEEEKPGISKQAKRLQKMLRTRGGNDVYESEEEDNPYTSSSRIFIQRGEDEEEEFNTHIGLAVPIEKTSSFKYSLLMKIHWSVQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZH9</accession>
    <name>A0AA38MZH9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_377202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZH9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="342" mass="35937" checksum="91E8E0F9F467747A" modified="2024-01-24" version="1">MSEQKALLLETVNGPFVVSTVPILKPGPDQLSIKVVAAALNPVDWKVQAWDILIKEYPAILGSDIAGDVEEVGEGVAGFSKGDKVFCQGYFVSEMGGFQQHALIPADIVGKIPPNVDYAQASTIPLGFNTAAIGLLRAQPEGAGLNPTFDPNVNFSGQPALVVGGSTSVGQFAIQLFKLLGYSTVIAYASARHADYLKSLGATHVIDRGEVPVGSLAEAAKKIANAPIKIAYNAVGDNDSRAACIDAIVEGGQVADVSPEAKDPGNGKRVISIIGTSHHPPHREFGRILWKTLPRLVQEGTIVPNRVEKIPNGLAGIDEGLQKLKANKVSGVKLVAFPQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1F7</accession>
    <name>A0AA38N1F7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1118668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1F7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000097">
        <property type="entry name" value="Potassium voltage-gated channel subfamily G member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="74"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3732483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="402" mass="46067" checksum="873531B40A9995B4" modified="2024-01-24" version="1">MPQSIELPRIRTSYPNHSLFLTEDRLSPVSRDISGLFVQTESYDQSELENIHPLWKRDLYALLEQPNSSVGAFLVHFLMTFFILVSAVVTVLETVPAFHSINPQIWFGIETTLVALFTVEYLARCTAWSSSWSSLLQWVISFYGVIDLLSVLPYYIEVIMQQDTAVFFRFSILRMFRLLRVFRPFRYNHTILLTIEVMYLSVRRSQHALLAISFFVVMMLTIFSTLLYFAERGTWDTTLETFINSDGDPTQFASIPAAAWFVLVTITTVGYGEITPRSFLGRLVTVPLLVFGLLLIALPSFVLGREFSIVWEKMTTQVNTFSGSQFFFSYFSLYHSNHINKTTTCSPVRSDREISTRKLALNQAELSKQISELRNTVDAQAELIQKLLTILEAKSKGKQRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1F9</accession>
    <name>A0AA38N1F9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_182387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1F9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="224" mass="25378" checksum="6E0BA3A0EB9CDF22" modified="2024-01-24" version="1">MSQPSTPTSPSAPQAEIIQLCSRHFTAIPLSLSRFQRQWFLTFPRTYRLPDPDSQRIVCALNSPDYSASNEHARTHFWLNPSCRSQRYNPSDNTTKYSAVSPIHLLLDSDHPVARLTGRIRSEPSNDPHDEGKRIACYEVEVMTPDDGLLRQCYYCLSWEASGKANTRFCPGGNDVYWCSSCEAAGWVFSTIRKLRLQNILPWSNTDGNSKDNLYSPTRLLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1M5</accession>
    <name>A0AA38N1M5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1070871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1M5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3733052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="184" mass="20365" checksum="3206B08B090D972E" modified="2024-01-24" version="1">MFKKFQSSTDISGQTPVKSSVQRSIRSAVLEQWKIEPETLEAVWPKKEGLVLVKCREHISIYTIHGEPIFFQHFDGPIYPTLRLLHKYPYILPMVRVDRGAIRFLLAGAHMMCPGFTSKGGYLPPAEEGLAAGVPVAIHAEGKEHAVGVGITKLGTEEIKRVNKGVGVEIVTYVGDDLWAIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1Z8</accession>
    <name>A0AA38N1Z8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">40S ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_993006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1Z8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21377">
        <property type="entry name" value="CTWD_Cns1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="8">
        <location>
            <begin position="231"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="544" mass="61530" checksum="9BA36B682ABBF361" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2I6</accession>
    <name>A0AA38N2I6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial chaperone BCS1-like ATPase lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_73528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2I6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial chaperone BCS1-like ATPase lid" evidence="4">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="233" mass="25840" checksum="F6D6A35A27E0640C" modified="2024-01-24" version="1">MYLNSNPTLKTLSPIESNLRLRRLKSTANQNTRSPKYSTPRLIVAERLVHCSDELSVAALQGYLLKNKTRPRECVEEVAEWVVQERQTREKLKKEKAEKEAKEKKEAEEREQKEKEEKEAKEKEEQETKEKLEKETRSKAKQTATVAKESLSVEPSTSPSTNTASSLSESSSSESENSSGVDADTEESVTSEEESDKDGSVAAKDTTKEKWIAVANPASASPPATSDTPNGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2W5</accession>
    <name>A0AA38N2W5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0057-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1151070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2W5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="52" mass="5661" checksum="C9914AFA57C11158" modified="2024-01-24" version="1">MAFTTSDICKILIAIFIPPLGVFLERGCNADFLINILLTILGYIPGIIHGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3D3</accession>
    <name>A0AA38N3D3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1130026</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3D3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3735736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="584" mass="64803" checksum="C813ABB4D58DCF75" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3E3</accession>
    <name>A0AA38N3E3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_992923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3E3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689:SF1">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="169" mass="19772" checksum="A6F05CAF6CEFDDEC" modified="2024-01-24" version="1">MGEIWYHFRSRVCIIFFSCKLSSTYASIFSKTSEFQTWLVEERKINPETISKDQNKKEFARFIEDFNTATLPHEKYYNMEAYEKRMSALRSGEFLPPTDDYYDPSADMKALSNAHKKKGTDSSMYLSKEHLMELRKVQNERAEAGKMKLLGMDIKQNLGVRMDGTVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3H3</accession>
    <name>A0AA38N3H3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1037775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3H3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="328" mass="36279" checksum="3423BF758680BA03" modified="2024-01-24" version="1">MSTMEKRNSRSLNPVYKTIALTPSSFISNPTANRKLLVLDLNGTLVFRPKKYVNTTLAHDGPSSAKVRVIHPRSYMTPFREYLFHPQTKKWLDTMVWSSAQPHSVNDMIQHSFGDHQGELKAVWARDTLDLDPVAYNKKSVTIKDLTKLWKAFPSHSAKSTLLVDDSTQKARLQPWNHIFVKEYGQAERRSDLDYLRKQNVSQGSPGDKGNDHHDLDVSDLLGNMTLTPSFAKTSLASQSSSTGFDSILLAVIGILDVLKHQDNVSGWLRSGGIVLCGAEGVTGGGGGGTIGDRWFDTAHIVEWWANRGRAALAELNIEVVAGALTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4E1</accession>
    <name>A0AA38N4E1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_830850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4E1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="387" mass="42343" checksum="8F332F31E6BC6441" modified="2024-01-24" version="1">MYDVLGCQEFMFCTNTPRTFIPIKLPTSPNQMSTETTIKRKKGSSDKSKPQPTLDGDHRKRSRNRCIRSCINCHASKRMCDRKRPACARCTQLGLTGLCVYEVDDPNQRSNTQDESSRLLERVAELEGVIRELKNKPHPRWISSACSEHSDDAPNLAHSSGRPTKGSCIQGASPSHAHREESCLPLTPAFSTSSPSSPSSAVTPPNDSPASPHAVIHDDSARLMDLDLDIFAQSPTFAGYSEDSIDIHQQFPGLGILKSYSAAQPCSCILEASNYHTMLELSLRLRKAATILARSPHHQPGAHCLLNQRLSELDALTTDTLSSVDSPHLSYSAVHPSTMLSSNLPSTIYASGNSASRLDNWLSGAITDTKNAGTDSFMSWDPPRRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N505</accession>
    <name>A0AA38N505_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_987232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N505"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="186"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="544" mass="58410" checksum="312A1200305964CF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N520</accession>
    <name>A0AA38N520_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_986982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N520"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60815" checksum="195AC8876C644611" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J180</accession>
    <name>A0AA38J180_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1109037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000141">
        <property type="protein sequence ID" value="KAJ3710336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="231"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3710336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1492" mass="168195" checksum="79E6DE31729985D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1D5</accession>
    <name>A0AA38J1D5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADP-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_114657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000123">
        <property type="protein sequence ID" value="KAJ3711121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1D5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3711121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="190" mass="20777" checksum="0D21DC53FD1BA2DF" modified="2024-01-24" version="1">MCASITLYSPLNHWNAGPGKTVGIIGFGGLGHMGVKLAKALGSEVTVFSQTNSKKELGFRLGADDYNATSDPDVFSRLSQKFDIIINTVSAEIPLDLYLSCLRRDGTLVQVGAPKDQLRISPHSLYARRIGVNGSMIGGIAETQKMLDLCGEKLIFPEIETIPASYIDEAYERVMKSQVQFRFVIDISTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1M8</accession>
    <name>A0AA38J1M8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1008640</name>
        <name evidence="2" type="ORF">DFJ43DRAFT_1009311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000143">
        <property type="protein sequence ID" value="KAJ3710248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000112">
        <property type="protein sequence ID" value="KAJ3712097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1M8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3712097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="94" mass="10730" checksum="6F45F9BED47B6E01" modified="2024-01-24" version="1" fragment="single">MLRDRFYPTSQSLEDPQRAHRTHGNPVLVEALKKLSLEGRLKFNRDIEVKNEARRLKSIDHAMGNASRPGSPTTSFVTVDSEEIDLIRKEPAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3T9</accession>
    <name>A0AA38J3T9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1134336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3T9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000005">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3718132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="292" mass="33132" checksum="1109D40265772F7F" modified="2024-01-24" version="1">MESLVLISSSVFQFLQWILAQLRITRLAQRSLLRVLAAGPIPQHVGFVMDGNRRYARGKGKLVQEGHGDGYLALRRVLEICLRLNIRCVSVYAFAIDNFKRPQQEVDALMQLAESKLLELCSHGDLLQEYGVKLNVIGRRTLFPDSVQAAVCKAEDLTKGNNRSILNVCMPYSSRDEMTTAVEDCIREALAKDVDYFTADDPIEGITEDTIDSHLMSVKRGSPPLDILIRTSGVKRLSDFMLWQCCENTQLHFSNTYWPDFGLFDFVPIIFEWQKSVWFRRQDVLFGGSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4H5</accession>
    <name>A0AA38J4H5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ctf8-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1134027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4H5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3720819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="153" mass="16732" checksum="D82E22F509A86B1C" modified="2024-01-24" version="1">MIIPVTFDAHSSSSSNAQKLPPSLAKISHDEVVLLDLQGALELESTHPNERDGKLVGTLSIDNDLKRPILRIGHHLIEGNLVNLPKPLAVLHRSPVSARISNSQVDEDVAMDSREESSESIINSPTIQWNALAIVKRKILFSKRPMPVVGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J523</accession>
    <name>A0AA38J523_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1044726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000162">
        <property type="protein sequence ID" value="KAJ3709694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J523"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="56"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3709694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="348" mass="38989" checksum="11A958870580D2BA" modified="2024-01-24" version="1">MIFVGVVISAVKCFLDYRNVPMITGNLCMVLDEGFNSEDGVFGDNGTNGEFEMTTDSENNSFVANVTSTFPDDVLQHYQGLSYTDSSSNTCHKLNETAIGSNTLTLKLTISVFCGQQCYRGNNHQPVQSARLSTRKTASMKFGRVDVVAKIPTGDWLPQCANVACDLDATVDDAYGAWPLSGEIDIMEAREEPIMSAVVKLGPLTWLNEVWRTYGWWQMKRGSFDKGFHTYSLEWTEKFMYLPLYVDSRLHHMLELNINEAFWDREWSEVVALQDPWINGTKAAPFDQRFYLILDVGVGGTNGWFPDGPEKPWLDGSLNTEPSGYARFLGSSGSMVPNWPTNQTNVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J542</accession>
    <name>A0AA38J542_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1092685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J542"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3722689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="235" mass="26269" checksum="E84CFE629DCCED79" modified="2024-01-24" version="1">MAIDSTWYKYEMRFRSSSFSNKLEGFDTLRPDYPYYPVLIQPLGAPAMSNITKLVTITPLHKPHVPSSPVYNVPLAPRNVPEDLVDDSLEFMSTLEPPKSDIWSRFSSPGGFFDESGYYFPPIDPPMDPEEMKEFAEKYFSPESGFSSADQAVFFLDDSESTRRDGTLPDFLSAGFDSPQSSEELEQFLLALTSSEWPDVMSALNIDTEVFGEVSAVVESIPENTTTSEMMGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5N6</accession>
    <name>A0AA38J5N6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SIT4 phosphatase-associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1158747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5N6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="979"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3720791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123259" checksum="942A364B9FD81585" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5U0</accession>
    <name>A0AA38J5U0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1158717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5U0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041350397" evidence="1">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3721375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="129" mass="13194" checksum="5D853FC08960A09B" modified="2024-01-24" version="1">MFSTKSFFVAFVAFVGAQVVSAAALAPATITACSGAGNPPQGCVTIPVVSDDCTDLTGGLSFLNKEITVVTVPDGFVCSFYSEFGCLGSQNAHNVVVLTGGTWDMSSVPGIASTQDFNDMTSSFTCSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6H3</accession>
    <name>A0AA38J6H3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_654597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="198"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="1071"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1485"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="750"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="829"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1548"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="625"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="942"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="958"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1551"/>
            <end position="1563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3723505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1604" mass="178572" checksum="512BA046B5FFFAE1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6U5</accession>
    <name>A0AA38J6U5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1088595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6U5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12372">
        <property type="entry name" value="RRM_CFIm68_CFIm59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3725658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="294" mass="31232" checksum="C8F3A8F1B930C089" modified="2024-01-24" version="1">MQQDDFDIYGEDLQQQVQNEDPEPQKVPTEVNKVEPSVGEKRERENSEEPVGHQEEQSIAVMAGATQMPGNTGLMNTQSSTNSDSLYIGDLQWWTTDEDLRQVGLMLGVNLDHKDVTFSEHKVNGKSKGIAYVECGNYDNATALKNWFDNNDFQNRKVTATLTSSSQGNPFRTLPKEPPAREGRVQPSQNGVMQPQVNNTRGGGTFRGRGGMRGGVPSSGAGPGNMGMGNMGLNMGNMMGMMGGVGVGNMGMNNLGMGGFMGGGGTFGRGGGMMPRGGGMMARGGGMMGMGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J824</accession>
    <name>A0AA38J824_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J824"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="60357" checksum="C8E4AC298C8FBDDC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J893</accession>
    <name>A0AA38J893_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_857735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000089">
        <property type="protein sequence ID" value="KAJ3714637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J893"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="423" mass="47436" checksum="E70C64F43E4E2C61" modified="2024-01-24" version="1">MTSYFRSTTPLSEELTDLIPHEIHEYIISFLDHTPTLKSCSLTCRAWLQASWRHLLAGRTLVVHRENIEDLLEIVKRNLHSLTIIRFVEGLYVEQGGSLRLPFLLSPWIEGENQQTFQFDDYLPLLVGFKSVKRLRLGWVRGDTGSPTVLSLQNNFGAGVTSLELNSVILCSPLQFFEILHALPQLTSLMLVGLKLDSGRQDDEEAPGTTLVHTPKPPQLQEFYCNISKDVAEFIFSWIVFHGSIPTRTLAVGLFNSSTNSKISRFLSESGSTIETVKIWDAYAATDFDLTPCTKIRSLKMGWIHLSSSSPPGSETFVTDVLSTVSSTCLEEVLVVLQILVSNSPGVESDLDAFDWRGLVSVLQQPRFKNLRKVCFSVSSHTDVVSQALMKHIKPVVSSGKLPFNRDAFHVVSWTRAEYGGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8Z9</accession>
    <name>A0AA38J8Z9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1042919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8Z9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="264" mass="29429" checksum="0EED9C8649698EF3" modified="2024-01-24" version="1">MPITPAAAFFAPDDFPELSLNWGDREFEIVRGPDETPFRVTVDELITTIQTSLALGRGWKICVIPCYPEIARVMNHTIPGDCDAYLSYIKEGHLYRSKTIITYSCYFNASQLATLRDEKKISDSLNRDTTTRFPKPPRREVNTKVAESITGATLANFTKTDMDQSILFAGLMAHARETQRKNLWKLKKQTTLPKATRGAERYAISESGSQSTTMGLNAKISKWRLTSTKNTAARRDEEDMDTASCDVETNDQEGGPSGEGPSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J966</accession>
    <name>A0AA38J966_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1159245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J966"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="192" mass="20775" checksum="8A08E9B0288DEFB9" modified="2024-01-24" version="1">MASRRPLLSMLRRKPFTGISSQYHAFSANVGDVEPFALPHIEDIFDAPARLLDRTGGRRHLSERGSSAPVTAFSSPAMTPTSLPAPLLFQGPAHPRSSFSSLLTKPPRQMVKPSSSTSSRKRSNKSPGMYRSSTSTPTSIDNASMHTYDGPSNITRYRYSGQKKKNDDGRKPLLALVSLATLAAGATVCLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAN4</accession>
    <name>A0AA38JAN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1132426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAN4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3731499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="466" mass="50895" checksum="EBCE4263A63F1ADD" modified="2024-01-24" version="1">MYPRLSPRVISEESNLMDDLDPRPEDDRKLMRRLGLSFFLFGLINNVLYVIILSAALDLVPSSTPKGIIAFCNIAPALVAKVCWPYVLKGRIRYVKRIFGCCILSSLGMLVVAFFDSLFARLLGISLASFSSGLGELTFLQLSTTYAPPSVAGHGLGYFASGTGAAGLVGAFLWWEVRGLGVRVGVGLSSILPFIIPATYFFLLPSNSAFLYTSLPPSGYESPSGQGHTLPYTPLAATEEELGEEEGILRAGPRKNVSLTFSDKVKLVRPLLGKYMLPLCKCNSNGVAPTLLYPVPSPDKHWLLSKIIHSIRDYYPLWQLVYQTTVFFSRASISIGIPALPPNLLPLPSVLQGFILLLLVFESSIGFYAEDAEGLSITTVLLLISLEGFCGGLAYVNAFYRINQERPDPSSVHNMERAKQEKEFKIGSIGFADSSGILFASLLAVPTELALCKAQTRRGKMLCKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAT5</accession>
    <name>A0AA38JAT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAT5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="1">
        <location>
            <begin position="183"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="435" mass="49132" checksum="E1E11CD1855C3ABD" modified="2024-01-24" version="1">MKMKKLTRMLEMTRFYPTIVKMHVKVVGKKGGYANRGLLIQTVHDDDVDFIPPPSQPFNHNYHSESEASSRVDLSMIPEEDDSEEDEAALIPKQKISKARDAKYIAELPAIVPPPMEPRTIQKPIRKQLARSRISHTSHATAATVADLNDDWPNLTALIYPRQQRVISLTAQTQTIQRVLHEAINLAIGLAIFQNGFAPTAQQLADSKNSIVLAATKFELPDIVYRFERDDLYARHLITYVTGRVGHMRGKVKDAAQELVPSMYGIHQIPVENNARKSFVANLLSRMNFIFPRTNMAESSSICTIMRKYFFSGHKSLGRRFHETFSSSVNSDDSKEIPRAMLGIVVVAIFAALKEWSEGCDQRMTQDFVSAEFSDEYDLHMSLIQSKIHKEDGSGKLKYHALMSWLYREARIGEGSNVKATADKMPELDFDGMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAT8</accession>
    <name>A0AA38JAT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1005758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAT8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="150" mass="16718" checksum="8D26C341A090A706" modified="2024-01-24" version="1" fragment="single">RLMKQCKTFLLQRQMIAEGSPFFCTTPHPQAAVYLVAWIMHSCDSINLNGSPINTNVEQSTYTHAQKMRAAATFGFGRIHSLGMQAWHQSEISGQMLGNPSVSETVSSYMLSLRRRKASFIYIYISFISDHILQTHAGETSTSARAVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBC2</accession>
    <name>A0AA38JBC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_727976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBC2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="178" mass="20337" checksum="07287CCEF9F01B13" modified="2024-01-24" version="1">MRLFPSSKDLSLTTSFVLTLGLVSVMYTTAMPTPHSDSALSKNPENSDKKLKVSFPESNKLTEIKITEDRMKGFVELVQDSILEGYTGTHFTQDKAFDHHRLECGEATPRLYKVNPEQYQIPFSLATEQGNIKGWISFWRDSYGHIPGPYANVKWQGRNDKVKLDVHYCYDLWGLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBM3</accession>
    <name>A0AA38JBM3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1138014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBM3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="283" mass="33211" checksum="DCCF9A0F7BFE9DCC" modified="2024-01-24" version="1">MDVEISESTLTQESLVSYMNDRTLLMKVLISSTVILFYDWILLLPEEIEFIWSAKLLRPFNALYNIQRYMPFIDTVALLYIVSFAEQIDVEKCRVLYNISGWMYIIGITLTEVVLTMRIWALWGKDTRLSIGLPLFFLSCWVPNFYIFHKFLQTETYIPSPLPQIIGCAILGGQPILYLCWVILVVYEAVLLILMLIQYRRQFSLTRVVYRDGITYYIILFSTILLLPHDLQNLFTPPQRVIHTILTSRVVLHMRKQSGNQLQYNNDEAYYRQSLQPLEIDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBW0</accession>
    <name>A0AA38JBW0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1098546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBW0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="294" mass="33031" checksum="D9DE22374C009A73" modified="2024-01-24" version="1">MSCLYPKPRIPIHDNGKQATCLAELCERLNTSSETIMHRLNGVGLAALDRHTTTSRSYDLLSNSLSQNQITHLQSQLVSFRSALTTFAIKHREDILHDPAFRHRFTQMCSSIGVDPLAGPRKGGWWAELLPSVGDWQYELGVQIVDRNGGMIELSELVRLVRKLRGLSADQDGKGKGTINEEDIIRSVKTLSPLGAGYTIVTLNDGRKMVRSVPKELDEDQAIILALARAPGKYGRITIDELVLERERGGRGWTRERARGALDNMLLQDGLCWVDEQDNIHDRVYWVTSAMKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC50</accession>
    <name>A0AA38JC50_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1225779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC50"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="389"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3727205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="501" mass="55720" checksum="D7BB9CF30DDA099B" modified="2024-01-24" version="1">MIDTPLDEIPKINASLHATFATRKTFPLAWRQHQLLQIARMLQENHKAFADAIYADLGKPAFEVYMTELNLMIDRAIISAKRLPEWAAVKNLENHPDLPAHQKAWKPRVAPTPKGAALVISPWNYPLILSIQGTIGAIAAGCTLCLKLSEVTFNYAGLLQDLIPKYLDQDAVKVVCGSVPEITKVLEQKWDHIFYTGNGTVARIIAAAAAKHLTPLTLELGGKSPVIIDPEFDMELAARRVLWGKINNCGQVCVSPDYALVTPSSTAAFAENLKKACASFYPNGSLKSDSYTRMINMQHFNRIKSLLERTQGKVLMGGGMDEKERRIEPTVVLVKPGDVLLESETFGPILTLLEVEDMRAACEYISAQFVLCLPFRQSDLDPSRSDHPLVLYLFTQNEQLQQDVRKLTMSGNLIFNDTFMQMDVKVLPFGGVGESGYGRQVLENTFNCFTYERTTLEIPVDVEDKIHLRYPPYTAHAFEVECAPTLNVQIPESSPEGGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC96</accession>
    <name>A0AA38JC96_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1094884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC96"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="57"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3721378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="507" mass="55048" checksum="90C6111527278319" modified="2024-01-24" version="1">MNGASSGDKLSNTVIESNPESKPPSSEKTNITSPKDFGFLPVPKRLRYDPDNPFHFGMFLNILFGVTSTFSVANLYWCQPILIELSSSFDVSYNEISKLPTLIQAGYATGLLFISPLGDLVRRRQLLLILIIVSASLTIGLSLTPNLPAFQILSFLVGVSSVTPQVLLPLTADLAPPSRRATAMSIVFSGLLFGILIARVFSGLIAQFANWRITYYMAIGIQWVLVLVLFWNVPDYPPKNAGKDGEDGKLGYGKIMWTMVKFSVTEPVLIQGCLCNMGSAAAFSSFWVTLTFLLGGEPYNYSTLIIGLFGLIGMVGVALAPLVGRFIDFLVPWQASLVACIGLLLFQIVQVVGNGLNIAAVIIATVGLDVFRQMLETSLAISIFSIAPHARARLNAIYILSLFIGQVLGSSAGTKVFLTYGWRATAAMTLGFTLWALIILLMRGPECERYTWFGFGSGLRGIRDIVCGVQDLHRSTGRSKAQLEKSVNGRSDAGGQRDIGEGETEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCB2</accession>
    <name>A0AA38JCB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1152619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCB2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="106" mass="11478" checksum="FE8593A252662A92" modified="2024-01-24" version="1">MEGVVFRPNPQNLLDANNNDDANNTGGNGDTTTKGIYRPPRVAPMPYVPQTSAKTNRQQRTPIPSSLVAVLHTDSSMPHVESTLGLGNTPSLNHTSSRAKYLQHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCF0</accession>
    <name>A0AA38JCF0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_676110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCF0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="121"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3722046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="599" mass="66091" checksum="B539D2D4D465D1FA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCG7</accession>
    <name>A0AA38JCG7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1133907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCG7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="8">
        <location>
            <begin position="141"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3722076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="191" mass="22007" checksum="F3A8D451E5B21840" modified="2024-01-24" version="1">MANTRQFGDLATQLVMESRRSTQTDALLKYNDSLVRSLLREQRRNERISGSPPALLIIQTAVSRNKRCLLAYHSHRIDRLRDLYWAVGGALPHILNNQDTRSKLSPHEVDYLRQYNGSVMEFRSEFSHELDITANITNPPKDLHVLVHVVRDCGVIQTELGSINFQKGQRFMVRRADIEHLIVQGYLEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDC5</accession>
    <name>A0AA38JDC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_488298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDC5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3729171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="534" mass="58771" checksum="930353B17FF70F47" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDE3</accession>
    <name>A0AA38JDE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_680535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDE3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3722099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27202" checksum="7738011F0482B10E" modified="2024-01-24" version="1">MNMSGAGKTAIVTGASSGIGRYSAIALLNEGWNVVITARRYEALQETQKMSSNPDNCLCLTGEITDEDFVMKLFDQTISKFGRLDLLFNNAGISSAQVPIENLSLDDFQKVLNTNLVGPFICTREAVRQFKTQSPPGGRIINNGSLSAHVPRPYSYAYTISKHAMNGLTKCTSLDGRAFNITCTQIDIGNAATEMGGRHGVGALQPDGRTIQEGVLDVQHVASTIVHISSLPPDVTVLNVNIMPTNIPYIGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDJ5</accession>
    <name>A0AA38JDJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1104939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDJ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="302" mass="33253" checksum="B12563735AA86415" modified="2024-01-24" version="1">MYFQSASNGKFMNTKHYGLLLSMDSSLSISSGLLLLSPLPGLMTLKGFEDSHVFPTLISSSPPSPLLGLNLRNLDEDRLASSSLNSSGRLSPLYELTSLSNFGPALTSSDIISSSSEVGALGDGHDRSGIHKAGPATSNMANQYTVTSGAQFTSHNDRNAYLGHFIHRNAMDKKKHNRDHAEDQARAPPAHLHSPEPDVLSCWETGPFSFIACGLPSDVDRDQELSRSRIGSCRIPDRKDDPIISNSHRYRWHGQRSICAPMPLCPLQQVLREMEELEKMVEDLLVCEVCVLSIEVFVYLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDR0</accession>
    <name>A0AA38JDR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1040507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDR0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="457" mass="50224" checksum="A703FC14DE696622" modified="2024-01-24" version="1">MSRRMEASQDDTFPSQRYLRRQWKLFKPPLPTRPRIKQETLLQAPRPIAIRSPLSVSANPVYSEADAYHSARSTEVKALDTSINALGIKSPSFEENVNIPDDTVLQRPDNIVANLGCGVVTPHPEAQSFATSSMLTPLHSVDPDASCHQSYLGVNSVRDGLTTLHGKTFGNHSSSNRSTAGCTPAYVSVDITPTPPLRRKKSYLILHMSTPPSKSANTWTVPSGQQRPQSQPAASGLTASASPAVTQSLWLPVTSLDHHMRVRARTQPDLPQLHLGHPSRPYYTALRKKMSPPSLSISPQSVQGSSSPFLSFPRVSSPVLQPPYPASFYDDSFELSGAEHSQFLPLGVRTNSIPPFIPFGIVPPSPSANFYFPGEMSPGFQFRSIKDKFRRNSDTTTFSKSDEMKLRLALARKVGGAADVGSDEGFVNESRVMANVKLHVRRLSRGLKDFVNIKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDT2</accession>
    <name>A0AA38JDT2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 69 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1030795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDT2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF1">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041225902" evidence="1">
        <location>
            <begin position="33"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="524" mass="60243" checksum="2752D057B385C393" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE68</accession>
    <name>A0AA38JE68_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1057501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3735442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="412" mass="46599" checksum="56A741EAFED7F6BF" modified="2024-01-24" version="1">MDEIGIEIQKHEPTFESVVTEKTALYQELQEEDLYTKYKKLSRHLELLEIQEEYIKDEQANLKRELIRAQEEVKRIQSVPLVIGQFLEAIDQHTGIVGSTTGSNYVVRILSTLDRELLKPSSSVALHRHSNALVDILPPEADSSISMLGASEKPDVTYQDVGGMDTQKQEIREAVELPLTHFDLYKKIGIDPPRGVLLYGPPGTGKTMLVKAVAHHTTASFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILIELLTQMDGFDQGSTVKVIMATNRADTLDPALMRPGRLDRKIEFPLPSRREKRLIFQTTTAKMNLGPDVDLEDYVSRPDRLSSADIASIVQAAGLQAVRKNRYVILPVDFEEAWKQTVKKSNETHEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF70</accession>
    <name>A0AA38JF70_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1002537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF70"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="562" mass="63857" checksum="EC0BFAD959F17F7F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFL9</accession>
    <name>A0AA38JFL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_992112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFL9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="173"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="686" mass="75093" checksum="6338D7E1F1AF61AC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG69</accession>
    <name>A0AA38JG69_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_328775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12573">
        <property type="entry name" value="AT09986P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12573:SF4">
        <property type="entry name" value="AT09986P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="244"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="479"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="587"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="74918" checksum="E6C185087CCF953B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGC2</accession>
    <name>A0AA38JGC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_333951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGC2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="331" mass="37100" checksum="7259A52B048CC1FE" modified="2024-01-24" version="1">MRLTPVRLTNQAGLMKANTIRAFDDHTVAAMSSQPRFQSPLVNGHIFRVATNDGSNPFPFGRVGGQDDHENETKPDISATSCTASEDESKPLLSNAVVHQDDHENETKPDISATFCAESHDETKPVVDQDDHKDGIKSESNSDLDQDDDKVAASPTSDLPPAASDTVHPDEGSNTYMEDVPSISFTPFTPPTTAELTNRLRQAKRTGRTIHELIHELQNEFYPLLPPRGYVPLPALYSATVEELQALKRLLDLWGDDDDPNSPLTPRVVSQPAFVRKVTRQPWTLYLTDHLKSMALRAVKRRKRDEMHVDEEEGWVDENSSDSRSRKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGF7</accession>
    <name>A0AA38JGF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1132464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGF7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041277501" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="41"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="262" mass="29087" checksum="6FE7214B08AC9B48" modified="2024-01-24" version="1">MAFKNAAFAAILLASLFAKSFAAPIPRAKPLVRRTANAKRGIAFSDTTTTDLSYAANTAISWEYNWAISPPANLPSEIEHVPMQWGKASIENLQDAVEKTGFKYVLGFNEPEQTGQSNISATDAASMWQQYMNPLSTSGIKIGGPAVSSAPEGKTWLENFLSACDKKCKIDFLPLHWYGQGSQYFLQYLSDMHTAFPDYNLWVTEFADTTMNNEAAVQTFLTDSIQKMDALSYVERYSWFDYSVNLLDSSGNLNNLGKAYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGR9</accession>
    <name>A0AA38JGR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1081056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0390 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGR9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967:SF1">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="88" mass="9394" checksum="B6EE0222C216F3AA" modified="2024-01-24" version="1">MAQGKTKGLQAKAPSQRHAQKAASSTKKGKRHIPPKKTALVKQATMHKTLTAKINQSIEQQMVSAASAGKLTIMKNSAPEFSSKPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGT8</accession>
    <name>A0AA38JGT8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1225466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGT8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3729012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="476" mass="52775" checksum="C78DE0AEF52781B7" modified="2024-01-24" version="1">MSFASIMGITTDTHLVGQQYAWLTTCVMLQVYIAILIWEFPTNRLIQRLPIGKYLAFSISTWGAVLACSAACTNFTGLVIVRTLLGIFECVCQPAFVFLSTMWYTRDEQALVIGSFYSMNGFQQCVGGLIAYGIAHIQHAKLHNWQILFTLLGCITFVWGIFVAWWLPDSPMRARCFSPEDRILMAEQVRKNQTGLQNREFKMYQAVEALGDPIVWSVTLISFTNGLPTGSLGAFSNLIITAFGYSQLQTYLLAIAQGAIIMAALFSGAYLSKRYGQKLVLAFVYTLPNIAGTIVFLSVPTTSEMKIGLLIAFYCTQVFGAVAVLNLAVMSGNVAGRTKQVVASSLVFMYVHVFTLTVSPSPASEERGPIVQCCPALDKAKSTDSATWATGNAAGPQGEANDSPRYVKAFIAHIVIYGIQLAVIVFLRLHLMRRNQVKRRAQSLQETSEDLNVNLYDKRGFEDLTDKENPDFRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGW1</accession>
    <name>A0AA38JGW1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-xylulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1049955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGW1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="581"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="771"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="864" mass="91790" checksum="EC35686490C9CD70" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH72</accession>
    <name>A0AA38JH72_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1055545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH72"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="192"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3735971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="629" mass="70852" checksum="05CFA22C25E871E6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHD2</accession>
    <name>A0AA38JHD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_704076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHD2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041485987" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="33"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3736136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="608" mass="64498" checksum="B3C1B77BC152C837" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHK6</accession>
    <name>A0AA38JHK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CBD9-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_652094</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHK6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041241138" description="CBD9-like protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="186"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3723472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51399" checksum="174437BD5BE50C61" modified="2024-01-24" version="1">MWLPFVLTFLLLQLYQVAALKGDSQCGYLVCVNATVHHDTITYQMTARQERMGWLALGFGRHMAGSDMVVMWRNEDESLTISHRHGYDHTEPQVVEEPLRTAFLPMLQPTVWDSKLNPANTLAFSIPLDKSQWVHKPEKNGTFEPLIWAYGMTRPASPDPHTTIYGHYAAGMLLLNLEKDLPGTPPEDSINDTTMPRPSQDTQTASEERLPYTTHELIVLGHGFLVAIGMLVLLPAGALVARWTRTCTDRWFKLHKLLNYMIALPVILVGWLLGPFAVFEARASHFTDAHQISGVLILVIYLLQLSLGRYIHARRGRPNRATHAPSNIFHVCLGLVVIGAGFLQVRSGMNKWEAHTAKELSHWCHILWKVWIIALPVLYLLGLSLLKRQFYQESHGLNPSSAPKHYVALSPDEGHRSMLFNADIDLDSLPDYGYPNNTTNGLTKEAETAVPLLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHX8</accession>
    <name>A0AA38JHX8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1051586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHX8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="8">
        <location>
            <begin position="48"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="431" mass="48936" checksum="A60A2D393B17D447" modified="2024-01-24" version="1">MSRLSTRLIISRTQLHNPFGCSKRQESTALHFYQNKQLEIYASKEPKPLTLRQLIFFGRSMDEERLVKSANYVRTELPVRIAHRLRDLQKLPYIVVTQEGIAKVYELYWSAFEKFRKYPPITNIKENDAFCEFLAGLLDEHATVIPNLSLGMSLSSLYLAPDDLDSFMRRMLVSRISRRVLAQHHIALSEIYAGKHKPWDSSEPNVGIITTGLNLKSSIEKCANLLRHQSFETEDIDGNAEIPVEVQIEGDAEMKFSYIREHLEYIVFELLKNSIRATRSKHVGSTKLPPIIATIAAGDNAIGMRITDQGGGLLTLQNSVQNPADLFSFSHIRNSARMEHSRLLSLRTASSYHRGIWATVNEQVENWKRLPDPEKEDGVERHVRMGIGLPMSNIFATYFGGSLELKSLDGYGTDAYVRLPKLGTNLEAVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI45</accession>
    <name>A0AA38JI45_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reactive mitochondrial oxygen species modulator 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1090394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI45"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3724267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="118" mass="13030" checksum="BAB58388261E238F" modified="2024-01-24" version="1">MQAHQPSTVDKLKMGAMMGGTAGMAMGFLFGSWTIIRYGPGPNGALATLSKYMLNQAAFFGFFFSIGSVIRNDAELSQLQAPQMTRYAAAMAIRSRAEGAQMMKARWEEEKRRLLRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIM5</accession>
    <name>A0AA38JIM5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Halogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1143716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>melleolide F + FADH2 + chloride + O2 = 6'-chloromelleolide F + FAD + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:167712"/>
            <dbReference type="ChEBI" id="CHEBI:167713"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:67161"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIM5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140907">
        <property type="term" value="F:flavin-dependent halogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="528" mass="58117" checksum="826EE76FE5D78A0B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIR1</accession>
    <name>A0AA38JIR1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1054681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIR1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="11"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="444" mass="50933" checksum="C8E2F16352E02B25" modified="2024-01-24" version="1">MFEDTTSPKVRTHILCFDGTASEYDSENTNVVKFFSLLKKDDFDDQLCYYQAGIGTFFAPGVVSPLFQWCAKILDEAFAWYLNAHVMDGYRFLMQNYRAGDKICLFGFSRGAYTARALAGMLYKVGLLPRDNQEQIPFAYKLYTRTDHVGIKLSAGFKQTYCQNVEIEFLGVWDTVASVGVITSKTLPFTSDNSSIKIFRQALSLDEHRARFKPNLFHREPMTASGFSEIKDRRVETDSKISANLENQRKPLTRTLTDYFRKNKTVSPDITKLVCTTDEESTSGTDVLEVWFAGCHSDIGGGSVSNSTKESLSDISLRWMVRQVVESQCGIQFNEDALVQQFKIIGDGDASWKRLDILDSVQPLHDQLVLQPAWWLLEILPMQSRYQDVMRQWHTSYGWNLGRGRRIYIPKPYFHATVKHRCEDKALAYKPKARWEEGTEIYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIS6</accession>
    <name>A0AA38JIS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1186721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIS6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43600" checksum="EA93C052ED7E5DF3" modified="2024-01-24" version="1">MMSTDPYQPPLQLKGEIMDLEFTVDTDHRKRRRNRTTASCLNCHTSKTGLCVYEVDDPALRDDPNIDETTRLRNRIAELESLVRELRGKPHPRWADSNFRNGDPSEKWHSRATKTLPTSKRRAPSPELVEDQIISRSDVRGSNGLHSTLLSPLTPIKTESSSESSQLFRFSPSPAPSMRYHTFQTDVHAPATASAYEGSTRSSYRGPPPGGSYHTTVPTPSSPYSSAGHPGSGPSSYSDGGNTYHLSGSDDGRSFAGDHYSRNSPPDPPFCPCRTNPALGHTYISLSQQLENTVHHIRQFSHHPPSSQCQLYRLITDLNQLMQGIDPGEVSRAAYDSNTPTDSEILTPLSASSGPAAYHPASPGGVSPQEWTALNNTGYNSYFPVSAGDHGIYAHIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJH5</accession>
    <name>A0AA38JJH5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_322712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041426959" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="408" mass="46112" checksum="AE0489D48AD98819" modified="2024-01-24" version="1">MQGNMLTSTIWTLLLQLPQDLTEWRTHTRYITSWNHLRRFLAGYGYKLWAFDPLVDLSKPGVLAPPGLEYGNPSGFLYTPSQVTIIRPTVTQDEKSPSDLVTSLVHGPDLGLGGLAIPRRISWPARHEHGDVVIRVLSIDGDGLRALKILRQVATAPEALNRSNHTLPLFREIVLEDIILGVFPRVTASLAEVFVPNNMSFVAEMDILQIFTQCLEALDFLHQNLIAHLNVTFENLLIDFPPFSRPQTYPLTGRPRVYITNFDRAVSFPPSTPVTERFCLGEYFFLHHPQEGQEQKQEPAKDTFLARKRALENAQEDKEQSKKKVLKLKPPEIVDLRHRFSPFPVDCWQFASGVLALEPDSTEDSGDIGFKTIEPIHEIFRTMASDDPTCRPLASDALISLHNILHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJU1</accession>
    <name>A0AA38JJU1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_668590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="406"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="776"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="731"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1262"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1262"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3722132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1315" mass="148674" checksum="0D003598EC791D80" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJU2</accession>
    <name>A0AA38JJU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_144417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJU2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="145"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="420" mass="45478" checksum="AD04F98FD59FD282" modified="2024-01-24" version="1">MTPSSLNLNLNRTANASVYTLATVNDLNNGESSVHAPLLTPLTPSYGSTMPRSPGTTRSSKKLILNATLKMAAIFTISTAILGTTLWLALPTLEEDDRPMLRIPKSFEQLQDLNGLLKKYRDIYPYRIVVCYITVYLFLQAFSLPGSMYLSILGGAVWGVARALPLACCCVASGATLCYLISSALGPALLTIPRIKSHLDSMAARVQRNKENLISFLIVLRIAPLPPHWVVNVVAPHVGISIPTFWISTALGIFGVSVIHTTIGGGLDEMTSADDFHLISWKNFLGLSAIVLGVMIPVGLRYWFKRGGVTADIEGQDEDAPVSAITATPRSAANGAIYLYDEEEDEEDEILTVGATRMANKSKDADSRTQLLTTEEYIDEDGYSSEDDDSDIILEAGSSLNDSDLKSFKPLDAPSSSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK49</accession>
    <name>A0AA38JK49_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_293008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK49"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041442120" evidence="1">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="303" mass="28561" checksum="933E2621CBA03C12" modified="2024-01-24" version="1">MYSSSALITLLSIALALSSADAAPLGQRDASASVSVASSAATASATVGLVGGLTDTATGILDGAVSTVGNVVNGVGSTVDGLTGLKRDGLLGGVTSTATGIVDGSVDTVGNVVNGAGSTVDGLTGLKRDGLVGGVTSTATGIVDGAVDTSGNVVDGVGSTVDGLTDLKIRDDTNTTTNSASSTGLVGGLTSTATGVVDGVVTTVGDVVNSVGSTVDGLTGLKRDGLVEDSTSTATGIVDGTVETVGNVVNGVGSTVDGLTGLKRDGLVDGVTSTATGVVDGVVTTVGNVVDGVGSTVDGLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKE3</accession>
    <name>A0AA38JKE3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1016311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKE3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="195" mass="21210" checksum="3F517CAAD9A7F3AE" modified="2024-01-24" version="1">MEPPIYYSRAEFIETDTGNKVSRRATIAGPQNIILGGKTIISSGAIIRGDLRRSGPGHAVVISLGRYCVVGEGCVMRPPYKTYRGAFNYYPMKVGDFVHIGAGSVVEAATIGNHVVIGRNCIIGKFTIIKDCAKIADNTVIPPNTVIPALSLFAGSPGHFVEDLPESTQDIVEIQTKQYYSRFQPLDRDLNMSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL97</accession>
    <name>A0AA38JL97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1045026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="207" mass="22416" checksum="6E839513796C2682" modified="2024-01-24" version="1">MSNHDLRRQSLPPATTGSPLRPTSPLAVSSTPPPTTRTVNTPSPTRPLSKAPPTPPARTSTRARDLLRKHYGLGMGTPGSSGRNTPDERDPMNMDSPSFDAKAYYSQLITTANLSTLLKKENELIGEIRLLDSERQNLVYNHHHELIAASDTIGAMKSHAESLDADLDLLKAAFSEISRLSSELASLDQINGRENTPPVDSGNRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLN2</accession>
    <name>A0AA38JLN2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase of plants and bacteria-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_345767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLN2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="327" mass="37038" checksum="2E2A6BD7588D2C0A" modified="2024-01-24" version="1">MGPILSKTVMAPVNNHENTDPWVLPQLDFRVEDLSHPGAKLFFRQIPNPYDAIKRAVEASWKWLYGWNESSDIQHGKNSQMPVVTPPLALIDSVRRVKRITLTIRPMDGVAYTFGSDDGSEKEVHFSLNHIVNSHKGDTEIKKDIRVREEILGVLVHEIVHCYQYNGQGTAPGGLIEGIADCVRLHEKLSPPHWKRAPPKGKHVPEPDGKWVWDWNWDAGYERTAYFLDWIDTTSETWPNSPYTRQKNPEPNAMSSTRSAPPPSASSIPIQISPATLSPSRPLGKGLFFRALNARLKDAKWSSEMDLFLELTNWPRDALWEAYCAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLU2</accession>
    <name>A0AA38JLU2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1072590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLU2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46037" checksum="9B69F70997DB1BC1" modified="2024-01-24" version="1">MFPAITSNLLWAVTSAVGAGLCFLVLLAISAVWWHPTSRPHLDRVSFRIVMIALFANMIFGIASAVGGTMTHGGFLCGFSIFVLQWTLQISSFLLFSIALNLQLVVVNGFNGQNMEKFYIIVSFVFATVLTVPPYAANQYGWDPLEQDCWYKNDNLGQRLAWQISTQMAWTAITALGEIIASTSVMLFMVKHHVRTRRVFLSTQSISRSSSNSPQVIHANSYKRIILRIALYPLASCFVNLLSIFTALHSTIADGIHNQTDYNILLLSDFLYGGRAIVYALLAASDPALIRGVKTLYRVIRGTHAPDTDSGKQYSTADNQGRSDGLVVHVELTAINEAYAHDLEERTPKQTELGFLGTTKDPQPHEESRPVNLTRASPNLPELHRTSRNFTTLDIQRREEALRKEEAAFNKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMK7</accession>
    <name>A0AA38JMK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-binding Rossmann fold oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1086710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMK7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="3">
        <location>
            <begin position="154"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3727179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="376" mass="40471" checksum="2AAAA58713DB3AC0" modified="2024-01-24" version="1">MSQESKVPIRLGFIGLSTTGWASIALAPPLFEDPISSRYSLVAVSTSKPETAEASAAKYSELASKARGTSITVKPYHGSAKHIVSDKEVDMIAVSVKVLDHKGAAIQAIEAGKDLFIEWPVGRGLEETKELYEAAKNKGIKTLVGFQTRFTAYALKAKQIIDNGDLGKILSSTFIISTNGFWGPFTSSIHKYILSSSNGATLLDIPGGHALDLFTHILGPISSLSATIKNQVPYSTLLDSNGKPTGETVPNDGPNQICISGTLANGALFTVHLQSSMTEADFNWIIHGDKGVLRIVDDSDRTTKQGFFDASPDVYLNGEKVGIDVDVVTKRTGLNWEAFAVGDTSKFADLEHALKMKEVLQAIRKSSEDGRRIDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP39</accession>
    <name>A0AA38JP39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1138273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP39"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="94"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3732936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="203" mass="22440" checksum="5DBB2A9F4D4C0F9C" modified="2024-01-24" version="1">MSHTLPPLPYEYDALEPYISVEIMKLHHTKHHQTYVNSLNLAEAAYAKASTPKERIALQAALKFNGGGHINHSLFWQNMAASSEKGGIGGVLKDGPLKEAIIASFGSLDNLQKEFNTTTAGIQGSGWGWLGVNPSTKRLEIVTTANQDPLLTHAPVIGVDIWEHAFYLQYKNVKADYLNAIWHVINFEEAQKRFVEATTGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ94</accession>
    <name>A0AA38JQ94_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1131284</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ94"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="13">
        <location>
            <begin position="55"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="14">
        <location>
            <begin position="394"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3733566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="577" mass="62352" checksum="622BC3EE7C209DC9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQC9</accession>
    <name>A0AA38JQC9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1152214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQC9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="577" mass="62141" checksum="6EB6B7DF638077B4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQS5</accession>
    <name>A0AA38JQS5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1151925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQS5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15554" checksum="739F57B7114992EE" modified="2024-01-24" version="1">MPDDFEPKSAIKNASMLGLQTGALGLVYSTLQNALGQHSSGALGVFTRTGSTITFFAAMGAAFAFTEATVANQRQKNDPYNGAAAGCAAGFLAGIRARSLPIALGGCAFLGTTVGIFDKAGAFTGTESVLSDEQRSKFFKKPLDLKSSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQU5</accession>
    <name>A0AA38JQU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_994036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQU5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="478" mass="53975" checksum="11D9CC05A838ACE1" modified="2024-01-24" version="1">MDFTHLIPSPSDIQYALLSTLGTLLNRRSATNDVLRPQEDFDIDPITGFVPPQPLPRLPAEYEIWEDALSEAPEVLRLVDDLSGEALALRAEGEAWRAKIRARPTLDVSLLKDQPRLLQRAHLVLTWLVQYYVSSLPTTHPPTPKRIPESLAVPLVEVSRTLGMAPILTFADTITWNWDLIHPDQPVTIDNMKLAHSFSGRDDERHFYQVQAAVELHGTQLLRIIEDYNQLPNLDDFTSIFKVIKDLTRLTAIIGEISDLIQSMRSGCDPHIFYWEMRPWVEGSDSKGPSHPGWIYEGVDPKAPELQYLSGPSGGQSTVMHALDLFLDIDHKLQTKRHPAPSAENRKADRGFMDRMRQYMLGRHRAYLEQLEKSPHSIRELAQRTPILREPYNNAVKALKTLRTLHMRIACLYVINMSKTENPRSVCPAAAMMERQASAMEAGARAEKREPIRGTGGTDLVTLLKAGRDATTRAGLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR43</accession>
    <name>A0AA38JR43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1077664</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR43"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="403"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3731828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="717" mass="78851" checksum="837F07CC25222568" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRD3</accession>
    <name>A0AA38JRD3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRD3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="226" mass="25266" checksum="B2BF41D602406452" modified="2024-01-24" version="1">MSSRTIQLYFLFQIWTYRSEFGKRALKAVGRAVSDAAENILGRIEFVAGELAEDAWAYEKPGATRDASTGAMRSPLILETFAHHFEHAKSFKVKSEFGFLAGALALSAAAAVLRAFRAYENGANSIEDTRKEQEVKRKKEGKSRLSKNTETSFGEEPWADYSAEYYKTIYQANNTKRMVIFNGAEPLINIKKFEKQQVVDLTGESRAEASGETKGNDDMTIIFSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRG1</accession>
    <name>A0AA38JRG1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_992074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRG1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="181" mass="19857" checksum="A8A97010B8B69171" modified="2024-01-24" version="1">MTQYLFAHNTIRALHGASPLTWSEDLAAGAQTWADACNFKHSDGVLSEVPYGENLAAATGGEFDIDAAVESFMGDEESYDPSSPTFSDFTQIVWKNTTIVGCAYNTQCGNIFPTSSGMATLHVCLYNPPGNVVGEAEYVSFSFYVLKANLAFHHNFLNTMWCSTSFLLVQASVFFDLRFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRL9</accession>
    <name>A0AA38JRL9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1075314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRL9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="415" mass="44562" checksum="37DB8BDF6AC57D0C" modified="2024-01-24" version="1">MSTSNTEAAKIGSPAPDIPPENAIEHAKRAFALKKYEQAVDYYATALEHLSQTLGEDSPEIADLYFAYGKALLENAISQNAVLGKEQPEEEGVEDKKASGSSSDGPILSFSGDAEEEEDNAVDIFAEAAKEVAEADAAAEEEEDDDDENAEPEDDFNAAWEVLDLARAIYDKQHDEDPSNDDVALKLADCYITLGDVSLETEKFDQAITDYEVGLTLKSRLLSVSSRQIAEAHYKLSIVLDLTPGRLSDSIKHAEQALRSIENRLEELQLAKAKPSSPASKTEEVKPNPKGKGKAPAVVLSKGDAIQDMSASQIEGEIKELSELKEELALKIEELKVAPNETLAGSAPALVAQALDKELGSKSSASTSTALVNDLTNMVRKKKAPIIEVASSKRKADDGDDSGSEKKPKLDMGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS78</accession>
    <name>A0AA38JS78_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carnitine/acyl carnitine carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1151707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS78"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="102"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="212"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="336" mass="36806" checksum="A1B57819EF7D9048" modified="2024-01-24" version="1">MSENQELNPAVDFIAGTMGGAASLVVGFPFDTVKVRFQNPEFAQRYSSTMNAFTTIVRKEKFVGLYKGITSPLAAVALMNGLVFASHRFLLKIQLDANNDIPTMSQIALAGAGCGAISSIITTPTELIKIRQQSLTTPTSAKQIAWDIFRRFGVRGLYRGGTSTILRDSGYGAYFWAYEATCRYLNSRVPSTTRSSETSLVVHEFDHQPNQSSWTTLLTAGAVAGIAGWIFTFPFDVVKTRIQGTESSHTTQPLSTRLANTVSPPASYPVLSQMYSTKAMHSPVNPYRSTWPTIVNSYRSEGIRVFFRGLSPTLIRAIPVNMATFATFEAIVHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSF2</accession>
    <name>A0AA38JSF2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1037800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSF2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="263" mass="29717" checksum="CA7EA1CF6712401B" modified="2024-01-24" version="1">MNAKARNAGLDIDMFRPELDNRGIPTVPVEGDTTLSGYKPLMPRQAGQDAPLKKKKKKGEKKEKKKGKEKEKKKGKEKEKKKGEEKEKEKEKGEEKKVRIQEPPSAVTVQGDPDIANITLIPLGTPFNDIERIQFRIDLMGKFFKFIKKQKIDRYRLQPSNIPILYTLEGNSGAGGQLHKIVKFKLTHPKTCGAQPCRGFLNFSTGKFRIEDPSGKAIYCVGPSSSKIANLKMTNPSIPHPPAGYHRKPSTTVYDKKYWYEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSM1</accession>
    <name>A0AA38JSM1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_41095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSM1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="985" mass="105465" checksum="996730145F4858CB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU56</accession>
    <name>A0AA38JU56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_260406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU56"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="312" mass="34444" checksum="83D8294B323DCD04" modified="2024-01-24" version="1">MFGFFEGKSWDASDIPDLTGRIAIVTGGNTGLGLVTVRELARHGARVYMLSRNESKAITAIDEIKNEIPEANVEFIHFDLQSLKSAKQAAESFLAKEDRLDILVNNAAIMAVPYQLSEDGIELQACNGTGHVALTLPLLPVLKRTASEPNSRVRIVNITSIAARVAHKPDFTNLDTLNRPFWITGVRYANSKLFNMLFTNELQKRLEGTRIYCLSVHPGVISTDIWLGLNQSWPWLSPLHAIRRRLMLTPYQGALTQLYAATSPEVEAKDLKAAYLVPVGKVGNKPSLGEDKKGELGKGFMDLCEKLIAKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JV96</accession>
    <name>A0AA38JV96_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoacetate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_519467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JV96"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34910" checksum="B64FEDF7E490B46E" modified="2024-01-24" version="1">MTAAGQPSQNETDFNGILLAPAPWKLKARMWHFLVSPLKANTINGKSNAVFPAGWAAPFQAEPLAEGEFVTGHPGVIMLVQYTESPVGPYDELIYIAGKFSMHKEPDSNETNKAETGFRITRIYVSTKETAANGRRNWNIAKELAEFKYTRHSDGSWDLAVFPSNPLISETLETPAEVRRPNIPFFHISIHPIPILGSLCIPINFNILGSYFRLLNPPIPNGPPGSSPALVKSNTNSDGSIKEPKWASLVPGIKGKMRLVTYKPKVDVGSDLEGEDGRKRKAHLAIADGVNFPAVVPWKMGAYLEDVDIHFDAPEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JX44</accession>
    <name>A0AA38JX44_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_406472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JX44"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="186" mass="20249" checksum="DFD3A91C85C99B02" modified="2024-01-24" version="1">MSNTPIPPSCSQVKTEVSQICLCDASSQRVASLVASANPPPLSYDIGRSSQPDPGPRGGSSSSSSASTSSSRSGITHPYARLYAKKEEGKRRKIWNHALEKSLFNPFELSSLGAPHRRTIYMASLEAHVDQLHAQLLSLGYWPVSFESLEPFKGLNSKTAKSMVAGLQYDSSQTKLRLLELQRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JY68</accession>
    <name>A0AA38JY68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_987213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JY68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="87"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="199"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="439" mass="49129" checksum="673C41A78AA2F384" modified="2024-01-24" version="1">MTGPSEVQHLLKIIAQAANDALNEYARHGEEVPSIYETKTHPLDIAETAFTLKKAIRTLEGACNQLCSTLAPPLHTVINNAHDYYWSCLRVAAKQGLADILYDHQGGLHIEVLSQRLGINQDKLATIMRTLASRHCFREVAKDVYANNRLSLALRSQTPGAAFLDLQTCEGQQAAFYFQRYLDDPTYGPSTDLKHTAFTYSISGFQGTFYDWIKQNVMTRGMSGMNQVMGTLSILEVFPWEKYSTICDVGGGNGSFTWPLIQKYPALKVTMFDLPETIAAAEKVATQKINVNHVEFSSGNFFEKSPPHNLDIYYLRNIIHNWPDKSAVSILESVGKAMGNNSRLLIPYSLDKVGTNSSEMEELSYHIVQAPLPMLPDFGYGNMRLHNQDLTMLFMYNSKERTVVELMSLSQDAGLELSNVWDLGETAVLEFTKSNNRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYQ5</accession>
    <name>A0AA38JYQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_38821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYQ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="355" mass="39727" checksum="4998A4778F618306" modified="2024-01-24" version="1">MSNLSASSLLAGSWVNMMLYGTELALGGFYLINSRHNVFFRWSLAISLCIDTVCTGVVCYNVYLYLILEPKALTSESQPWTLPATILCTYHAALVEQVFFTYRYWQITHNKFVTLSISTLTAVHVAFAWVLGIELILNPVVSQSGLNLTIIAATLCAATDLLIAITTFHTMRTIKTTFSATQSLLRRISIQSVACGSTTSIFTIIMVSLLVTHNLEPFTVIFDILGRLYTLTILMNYICLRKSIAHATTAVAGSTQRHSRSHSLAFGTAHVPRSFTVPVGLSTIDETHSIHDLRSPPLQKSTTIQSQILLAFPAHRSPIPSLSSDILLRLNIFLRLKFFLHWAFDFQPWDYRRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZQ8</accession>
    <name>A0AA38JZQ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1150295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZQ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="422"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3736013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="459" mass="51073" checksum="022B4A8EF393B055" modified="2024-01-24" version="1">MPTVKATSHMPDFASQDILDGRFRLLDLLGAGSYGKVYKAFDNQPKSFTSARYYAVKVLLKADAQSRDYEMQLRELKLHKKVSSHPNIVTFCGALEENDYLFVLLEYCEGNDLFTAIVDKGIFERNDQLIKSSYVKLVDAVYYCHQQGVFHRDLKPENILCSVDGSDIWLADFGLSTNRRVCHDFGCGSKAYMSPECIGKETNNVIYSAPLNDIWSLGVILVNLVTQHNPWNYAHSSDPCFDAFLANRDSLRDALPISDSLNSVLKRIFDFNPVSRINLPTLRNEVLSLETFYAPNDQIDNPNTNTVPAYLPDDPIDSVTLELHPAVDGIKVEVEVEVDVDVVAGSLQRSSTSSKGSTSWSNIEWNELKKHLSLLQGVLPPRPKLFVVGSHSISRSHSSNSQDDLLVTPPYGPVDLAIDIPEINEDSSDPASPSGNRPLRFQPRFTVKPPVAFQAGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU77</accession>
    <name>A0AA38MU77_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU77"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="212" mass="23276" checksum="8A758AC8FD003AA9" modified="2024-01-24" version="1">MVLTIQTSLALGRGWNVTVSPRYPDIASTINLIIPIDSEAYLSFIDNGKLHRSNAIVTYEHFFTPSQIGILQEENKLSNSLNRDTAATFPKPPRSQRKMSPPGSITGAMIADLTKSDLDQSILFAGLMAHARETQRKNLWRLKKNNKMPRSIRGSQRYNSSEAGSLSTTTGLNARISKWRLGSTKATASIHRDADDMDTASNIAGPSRTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUC1</accession>
    <name>A0AA38MUC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_976193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000124">
        <property type="protein sequence ID" value="KAJ3711114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUC1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="85" mass="9181" checksum="345A66C06CE6AC47" modified="2024-01-24" version="1" fragment="single">ISPYHDKFSNFESIPPKSFRAANKQKFDATGTGSITVDVPNGVSVSALHLTEVLYSPEVGYTLISMGKLDDHGFLATFTNGKCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUV9</accession>
    <name>A0AA38MUV9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1169275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000126">
        <property type="protein sequence ID" value="KAJ3711086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUV9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="397" mass="44192" checksum="C76BAE989BFFED3E" modified="2024-01-24" version="1">MVIVQVFVELSIPEIWCSNDIQILIQPSVTARSIRVLQYINLTHYTRLALFRSKGSPLHVHITILPANPVAAAADRWQSAYIAIGSTSPSAAPCLSARQFLKGLRYPILEELTSECDSTGSTEQDEYCLPSFVRSPKLHTLRVVKMRWWPVCDSQSESSNAVLSDVVDGINGDLDHGEVLEGEIERRPLPHLPYSQIRILTGSASLPTLYTLLKFCSNLERVEVEQERFPALALPAPAALDLETAVERVILGASPTSQLHHNYSHIYDWNSTFTTSPTASSDNGFPKNIAIDAPRLHTLSISLATDQPPLTNWMRRTPSLKTLSLTGGKLTSKVVHEQVVNDIIGFLHRQRFFSCGGLENLSRPESFSGLEHFTLSTVEITSRQLIELFTHMPERDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV46</accession>
    <name>A0AA38MV46_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1100875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV46"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="625" mass="69356" checksum="1C055007FDFE26A4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWK0</accession>
    <name>A0AA38MWK0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1112973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWK0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="65"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="269"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="776" mass="86846" checksum="7031706C354EE8B7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWW6</accession>
    <name>A0AA38MWW6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_789979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWW6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="327" mass="37086" checksum="490B0D661460B932" modified="2024-01-24" version="1">MLTVDRSNVKIPESKINQAEPEHTKTHGHATSASFLEHQLGPTKWNIFTGKLGKRRKASKQQESPSGIIDLLVKTEIIKEVLCKFLPPAYSEVDYAVHTWTDGRVLLTRAAVFALSGWSKVFFSYWSRRVERLALFSFHDHRLRIISSELERRLAEDLTDSFNHGTSAHFEPNCHYAHSCCSTDTVVQSFTQMTTRRLDAVLKETKERTGFDTTKLRGKRSILDPYLVMKDRFFAISAPRSAHSQAHFGAFEGANDVRRDTISSAGKPITPSQSNYVESTLVHSFNNPRLKTNSHPGQSMFKLQHAVDPTADAAKDQSEFEFEWQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX60</accession>
    <name>A0AA38MX60_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1002802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX60"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="3">
        <location>
            <begin position="234"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="4">
        <location>
            <begin position="398"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3725019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="74056" checksum="87301CCFEE26CA1D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXF7</accession>
    <name>A0AA38MXF7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_730042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXF7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041486720" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="24"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3720221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="527" mass="57344" checksum="1ABB01DD7F6A3CBC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYF6</accession>
    <name>A0AA38MYF6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CEF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cef1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1048151</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYF6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="231"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="779"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3737459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="842" mass="93866" checksum="82A2EE9BB67D84FB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYI9</accession>
    <name>A0AA38MYI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_587273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYI9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3725065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="277" mass="29337" checksum="FCA18358BDD12BF8" modified="2024-01-24" version="1">MAAHALLNAFKANKPAFGTWLTTGGFVHARSLARALIGLPQKQSWIMLDCEHGLIPLNPAGVIEVIAAIHGVRDGPSALVRIPATGHGTGNGSEGVNWQIKYALDAGARGVLVPMVSTPSQAQEVVISSRFPPQGRRGFGSPYTQENWDIQTAGEYLNVANENIVVLVQIETREGVQNVKAIAEVDGIDGLFIGPYDLSNALGYPPPSPDPHPKVEQVIQDILRVAHEAGKKCAMYCTSGTQAAQRATEGFDMINVTSDVGAMQSGLAAEFKFAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYS3</accession>
    <name>A0AA38MYS3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_554045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYS3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3727248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="219" mass="25051" checksum="818E1B5774998D73" modified="2024-01-24" version="1">MTYTVFGYGSLIFKPPPHVISEVHGFLKGYVRRFAQKSHDHRGTPEKPGRVVTLIHKEDWAAFSASDAFPDEDIVWDPAFEKEVRGYLDYREKDGYTLETVDVWGVESNGQETIVLHGVHCYVGRKDNPSFIGSEPLDALAHKIWESVGPSGPNKEYLYNLVEAVRKLAPESHDSHLYALETESIRLLERLGVLSLNLYFAINSKGIYLFQQFLYLRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYZ9</accession>
    <name>A0AA38MYZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1155710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYZ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="4">
        <location>
            <begin position="41"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="581" mass="64706" checksum="CAF51C5AB72CAB3A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ68</accession>
    <name>A0AA38MZ68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1084572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="482" mass="50822" checksum="186B0FE7B350F6AF" modified="2024-01-24" version="1">MTTAPTSNSRASLLSGLRTGGVRSTSASIPHTAAPGGTFNIPRIVSHANPGAYNEEQDYLPEMSSYANNIGGNRIPLTAAVDGPNNRFSQQQRGMNPNVTPFSPAFTPNAMSQANQAQQALQMQMLQLEILKIQAAQAQQYQAEILAQAQRQQQAQNRRSSVGFNPPATAGPLSTGFDIRAATLNAQMRRAHQIEQQAQLGVGSDEHLPMTAALGGKFGSRTTSLNVPNSMMARYDDGGEATLPPTPSSTTVISGGTPLGNPSSNNINGGITQSKSDSATSWRRGGGKGNSVLANRSVTSPAVKVTPPPPERSSPPAGVALPATATSKFRPQPLRFSVVAQQPLPSVTIDTSEVNDNDDSSSTSSDKSGSHSSPTTPHSSSSNEMSLSPREEASKKLYEGLGIGRPASAVSNKEAPLQQYADSLQALASHRMASQPSRQPRGPPSGMDELEPKNFATRIRRQAIGGLGVLMDARERRDVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZA9</accession>
    <name>A0AA38MZA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DFJ43DRAFT_1084527</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ET3784</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="538"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ3729049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="760" mass="82488" checksum="C4BEF86671778059" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZC9</accession>
    <name>A0AA38MZC9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_418346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZC9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="439" mass="49216" checksum="D831A5D7E6334EE3" modified="2024-01-24" version="1">MSQRLIHLVYIHGFRGDETTFQTFPTHVQQYLTTHIPSHLNIKVQSSLYPTYKSIKPISSATKNFIEWLRTQPPGPVILLAHSMGGLLAAEAANDPSTTNDVHRRIVGLIAFDCPYLGMHPHVVVTGIASLFPKKTDNKMKTEAELNPSPDIRIVDRTKETENWEDKQDMPSPSHSSTSLPAKNEHSPKSDSLINRTMKFISSHSDDPLVRWTRKHSDEPFSAGKRWVMEHFQFGSCMFDPSGLRDRYVNLVSPKGLFWVNYWTITTPKEKRNASHNSEDLDPQQLLDDNNQALIRTGIANPSDKPSSSVDMGQLVSNSSTLSLENAHEESALLDPQSDVHAKNKPRMQQKQKQNAHDTHSKAGTKAKKKEKGGRHFVVLPTGLGAILGGGDHWEPVVIEGVDDEVAAHCGLFIPEQNLEYAKLVERVGHRIIEWCDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZE1</accession>
    <name>A0AA38MZE1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1000755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZE1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="80092" checksum="55DD0F996E70AA65" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZG6</accession>
    <name>A0AA38MZG6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1082292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZG6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="2">
        <location>
            <begin position="130"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="198" mass="22085" checksum="638C7656AD72CF09" modified="2024-01-24" version="1">MPEKVLETPYTVLDIDPHFSRVVRYFRASDYATWAATTVAVPGALLAWEMADPNGLKVNRITLAPGEKLPSGRIAVGNAIQIVTRRMATGMKVAAFLGFCGGFMLAYQNSSMRFYGWAENKREEEMDFAELSQRAKEGKPLYGESPQSPWVQGAAHRNSVFSQLKFSVFPMFNFVNHPHHGVDTSKYGVKEEAKSEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N190</accession>
    <name>A0AA38N190_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1154298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N190"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="106"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="588" mass="64552" checksum="169D621197FE2AE5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1Y9</accession>
    <name>A0AA38N1Y9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1153430</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1Y9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="609"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="430"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3733397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="681" mass="75792" checksum="601F6C1F5EF6463A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N282</accession>
    <name>A0AA38N282_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1138159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N282"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="576" mass="63730" checksum="E247852ACAF2951D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N463</accession>
    <name>A0AA38N463_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pantothenate transporter liz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1143139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N463"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3736875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="502" mass="55874" checksum="ACFBE8BC35B43B6C" modified="2024-01-24" version="1">MLAGNPEETGSLTVWQKLKSYIWDSDAHLKSDFERRLLKKLDVGILVIGCLGFSMRYLDSANLANAYVSGMKEDLAMNGNQYTYMGTFYTIGYALFQIPGTLAVTRVRPSVFLFVNEIGWGIFTFAQAGARTYNQMYAFRFMVGAFEASFFPSILYLMGSWYNRHELAKRIAIFHLSGSLGTSFGGYLQAAVYTTLDGVHGIAGWRWLFIVCGCMTAPCAIGLLVALPDLPSNTRAWYLSQDERKFALERAITLGKSQPGEKSLDWTLVKRMFSSWKWYGLVLGYVVYGSSCQNTSYFAIWMKSAGYSVVERNVIPSCSYLISALCIFLWGFGSDLTGSRFAFVFGPLFYGLLPTGILAFWPKNEKLILFAFMTGGVQLMTAVFFTWANELLVDDNELRALTISSMNGLQYSVSAWLPIVIFPQTMAPTFRRGFPGTFGLVIAGLIAIVGIKLLADRDKRQATQRAILQNSSGESSIRKESSIDGDITAAEGREEDSEAEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4X2</accession>
    <name>A0AA38N4X2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catenin-beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1129480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4X2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="8">
        <location>
            <begin position="96"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="626" mass="69968" checksum="F65B25629A77F69D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4Z0</accession>
    <name>A0AA38N4Z0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1052436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4Z0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3736488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="534" mass="60514" checksum="4638FB37C2DD4B8A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N559</accession>
    <name>A0AA38N559_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DFJ43DRAFT_18694</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N559"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="704"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="155"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="662"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="817"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3737700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1127" mass="123887" checksum="138643F2A221983E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5X8</accession>
    <name>A0AA38N5X8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_13337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5X8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd24007">
        <property type="entry name" value="ASKHA_NBD_eukNAGK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052519">
        <property type="entry name" value="Euk-type_GlcNAc_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43190:SF3">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="359" mass="38134" checksum="D8C812FD11AACDA4" modified="2024-01-24" version="1">MSLYLCVDCGGSKTSAVICDAFGDIIGRASGGPSNIAYLTIASFIETIQMTVGDALKTCTSPASVDTVGLPPPAGLEFAAAWFGISGADSPSIIEAIMNPLSSLLGVPRGPRLSVANDAHLLAAPIRMHADVSYAVTVIGGTGSIVVSFKEKEDGELQELGRVGGWGWILGDEGGGYSIGKESVRQILAEQDQHSVMESPPPEGALRASLRKYFNIKDVMELLTEVYVLDPTPSTVIDTNQGSPRYMSREKRLSSLSPLVFIAAFEDKDPLALKVLHICAKDLADQICIVVGDVKEGFPRLVKASESVICFGGSVVGLEVYREMVLNELAARGHVFKHVEFVDDCAAVGAAGLRLKYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J199</accession>
    <name>A0AA38J199_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000135">
        <property type="protein sequence ID" value="KAJ3710617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J199"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="18185" checksum="5D6FDAF219F51679" modified="2024-01-24" version="1">MYNPEFTASSLFVCDGTDPTSGPFCQDATMGIVFVAIVTVFLLGVVVIIMALIEGVCFIAAQAYTYLAKYNLCNRGNMLKRREQAVVLRELAVNRQERTLQMDVEIKVCERLTQILRRSSASAQERAYELEIEKDLLSEIAGCGGDISGEGSLIHRMPKIANRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1H3</accession>
    <name>A0AA38J1H3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1044369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000119">
        <property type="protein sequence ID" value="KAJ3711444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1H3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="136" mass="15658" checksum="2424887C0281272E" modified="2024-01-24" version="1">MRDVEGAINKAKNDLGLARSLANCQKRTSTDLELKGNAKRHRHLFKHSPKPTLCVAKLNVAVIVRVPVFRTGIRSVMIRVNLPYPRFRYEELDQYDRKNLQRNAAIMSSDETKDTNEAHMSSYEILLINSIHKSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1L1</accession>
    <name>A0AA38J1L1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1009286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000141">
        <property type="protein sequence ID" value="KAJ3710340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1L1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="483" mass="52947" checksum="59FA5343830E1C1D" modified="2024-01-24" version="1">MLLSDLPSDIIIIVLRNLPVSDLGALSRTSRLFYHLVNTYGWQIHIRCNPRPSFSLTKAREMWHPRIRLQYDTLSDKSWSTSHFVARPLSHPWPRKQQSTLAINNTRLIVAAGNTIYSYAFGTSRASGSPPLLFEGSFSLHEERNSQWDITALTFVHDNGEGKTLLCGFRNGTLARVVLVKEDASNKLALQIDMEVDLYSHTPDVVESISASGSLCLSLSSRGQARMRNIQPTSYTSISEVDLATRSWTTYMSDESSPYVAFGSSSKIAPLSVYSILEGSFSSTPTAILGIKSSQPMSHSAVYGICRSPLSSPWGASPQILISGWFDGVVRVHDLRSSSLTEHLSDNSNSSGIPTSAAPLRPVMSLNDPWSIEPVYSVSSGGGACSHLAAGSARHSVVSFWDIRYPKSGWSVYAPGNDPSPVYSVVLESSRVFGATDSRPFVYDFGPNVTHDTYPQLSPSPGLKPRRSVPGYYVTRYSHGHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2I9</accession>
    <name>A0AA38J2I9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1105115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000098">
        <property type="protein sequence ID" value="KAJ3713494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2I9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041397311" description="ABC1 atypical kinase-like domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3713494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="279" mass="32268" checksum="717DF545C77AEFA4" modified="2024-01-24" version="1">MTRSFLILPLIASLCITFPAFTHAAPTASQNVTNFQLEARNVPGIYSKADILKEHDRSWILGVYGEDLDYKRNIFTKTLPIHTRISNSDIPPRLDDNGGVLERYSRTKIAYVLDDQDQTIGVAKGYLKNEELDKWEAHAEVKALQATAKSSHEFDYGKKYGWPVAYDFRPVIVMNYVEGVDIVDSEQYQNAPRKEQKEMEKRYMKLLQNEVYYYVKKKGILHADFHSGNVRVTFNGGKIKKVKLIDWGYPGVFTVKKSVSEKDFKTWFVERFAFCNRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2P4</accession>
    <name>A0AA38J2P4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1103817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2P4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3714542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="412" mass="45604" checksum="F83FAFED88A51784" modified="2024-01-24" version="1">MPTGVAVKATKSNKVDVLIIGAGPAGLMCAFALARAGVDSVRIVDQRPTKVAAGQADGIQPRTAEIFKSYGLSDRLLSEGTQLHVAAFYNPSKSGGIELTDRVPDVTATDSTNFPFEVTLHQGAIESIFIDNMRDMGVEVSRPVVPTSIEVDEALVEDDEAYPVRVVLEHTESEPEDEEHNEIVHAKYVLGADGAHSWVRKHMNISMQGEQTNYIWGVVDLVPETNLPDVRNKCAIHSNNGSCMIIPREGDKIRLYIQLDGKDVIDDGGRVDKSRAGPEMILNVARKTLHPFTIETPQSYDWWTIYIIGQRVAERYSVHDRVFIAGDACHTHSPKAGQGMNASMQDSYNLAWKLAHVLKGTGHRTLLQTYELERRKYAQDLINFDKKFAKLFSGKPHSELNSDGVSHAEFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2Y8</accession>
    <name>A0AA38J2Y8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1102507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2Y8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3715228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="187" mass="20337" checksum="EA3AD3E68E862A5F" modified="2024-01-24" version="1">MTVDKRVLLLLDVQVCNLCDPPKGAPSAAVLRTNIFRVLTIARSAKPPPRIIHVRNCGEPGEPDEMKAPGWQLFFPPLVHEHVVDKLKNNAFAGTRLAELISPEAEIVVVGLGSDFSVRATCSVALDRGNEVILIRGAHGTYDRVEVLHGGGITPAFRIEAEVEAELEEAGVLILDMKDVQGIFTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3E0</accession>
    <name>A0AA38J3E0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_799768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3E0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3717216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="99" mass="11073" checksum="D7D978B0344A574D" modified="2024-01-24" version="1">MLTSTHHYLHLKLQPKITSELSIRQSIRQALLDFFGITGGSIHLDILWISDDGSEIVVRVDPRDARNVLAAATSLSSPKIQLVKESHFLPSLLSRNPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3U9</accession>
    <name>A0AA38J3U9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1160563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3U9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="505"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3715271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="762" mass="85964" checksum="4E167741E8CBBE4E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4X9</accession>
    <name>A0AA38J4X9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1042913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4X9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="312"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3718586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="451" mass="50026" checksum="1DA97DB6695740F9" modified="2024-01-24" version="1">MTSANTKRLQVAICGAGIGGLTFALALSRYPDIDIEIYESARALTEVGAGIGIFPRPWKVIKMLGLEEDLLQVTETAIVDGSVSGFRYRKSDQYEGKAFFTLVTQGSLMLFHRADYQQTLLSHLPKRCRTHCSKRLRSYTQRQSGPIELSFEDGTMASCDVLVGADGVKSAVRAGVLGEKARWAKGEGKWKEAAEILQHVDPIWSGATAYRALIPAQKLQAIAPNHQVLHTPGVQYLGKQGYIIAYRISGGKFINLVAFVVQHHLENTTFNGPWMSTVDVSAFSSTFTHWEPDVQILLSCVEKPMQWAIHTVRPMQSFVSGRVALLGDAAHSMTPHQGSGAGQAIEDACILAAVLGHPSTDRTNVAHRALRVYDSIRCPYAYRVMEASRINGRYFTLRLDEDGAIDIDKLPPKQQWEYLQRLGHAIVKNWEWAWTTSIDTALQEALRLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4Y0</accession>
    <name>A0AA38J4Y0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1158614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4Y0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041469733" evidence="2">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3721422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="161" mass="16702" checksum="7AE8C7A385831CCE" modified="2024-01-24" version="1">MRASFFIAGAIVIILSIFSVCSQAAPIENLLSRAGTGESSAADWKRSGTGESSAADWKRSGTGESSAADWRRSGTGEASAADWRRSGTGEASAADWRRSGTGEASAADWRRSGTGEASAADWRRSGTGEASAADWRRSGTGESSAADWKRSGTNEASAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J553</accession>
    <name>A0AA38J553_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prion-inhibition and propagation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1003941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J553"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="264"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="608" mass="69328" checksum="6DA8E144EA989EFF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5D7</accession>
    <name>A0AA38J5D7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_738081</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5D7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000608">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3719541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112027" checksum="674D1A9F57E63B56" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5M2</accession>
    <name>A0AA38J5M2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3724995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5M2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="175" mass="19922" checksum="9AB07F24295F1A76" modified="2024-01-24" version="1">MTSKNTLSSGKDGTPTQKRLNFPAKANTSERTSSPSHTETEREEFQTLIDKAVAWKLMSKSDNLSAILPTKLVQLAAAAKENGRTRTTQGELLDKIILIAKILQEWSWKDKTDEWRHELLEHLEEEINEKVNGINTKIEGSMEENGRSYEQSDGSVYKDSNDKQLHDRKDDLHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J646</accession>
    <name>A0AA38J646_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_557805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J646"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="216" mass="23927" checksum="C98F86615584C118" modified="2024-01-24" version="1">MTVTIREARETDADAVSRICLLTAQGGQSADDLHDFKELPGLTYAVPYVKLPTTLGFVMVDDKNAGSGDGSGEVVGYILASRNSRDFDRYAAEHWWPALAEKYPPSLAKKPADKEFMELFRNMHGKSDARVSYGAANMHINMLEPYQKQGWGSKLIGKMVEALRKEDPDGGVTLGMDPRNLGVREFYEKFGFESFEGGKFNELGLKFSKAKVTSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6M0</accession>
    <name>A0AA38J6M0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZSWIM1/3 RNaseH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_973541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000110">
        <property type="protein sequence ID" value="KAJ3712347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6M0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM1/3 RNaseH-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="100" mass="11110" checksum="F8D1BE2C41850262" modified="2024-01-24" version="1" fragment="single">GVTAIAFTFKEILDGLGNEIEEVLMDSTWKTNALGYELFSIVGEVNGQAIPLAFMFITLNKEASEGTKELVLRDFVRWISGHCPNIKFTLTDKDVIEINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J729</accession>
    <name>A0AA38J729_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_637875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J729"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3724225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31253" checksum="019B598A08595290" modified="2024-01-24" version="1">MGQFFDEIPNFLITWLEQQQMFWTATAPLSGSGHVNLSPKCTRGTFHIVNPQKVWYEDMSGSGVETISHLKEPGNGRITVLFHAFGGPPRICRLFGTGTVHEYGTPEYNEFIPKNRLPGSRAVIVVDVHKVGTVIFGFLLFTNYHLLTSYQSCGYAIPFYEFKSHRNQLLQWAQKKESTDNEFLEEYNEVSSKGLYSYWKENNARSIDGIPGLDSKTFNAAINPFKTGVFSYTSDDKSMATSRGTGSLANLLGTNGILDSKFLTGVVLGVLATSMLVRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J809</accession>
    <name>A0AA38J809_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1157016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J809"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3727180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="554" mass="63074" checksum="C294837653B34463" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J872</accession>
    <name>A0AA38J872_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1155767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J872"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="1">
        <location>
            <begin position="14"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="278" mass="30891" checksum="75BB090A80723DBB" modified="2024-01-24" version="1">MAQGQSIKDVLCEAILLATGLAVFQNAFALSDRQLVNSRNSILSTATSLKYPQIAHRFEQDRGFAKHLTNYVTGRIGNMRGQVKEVVQKLVPSLYGIHQVPIEDGQHKRFVSDLLLRLNYIFPRAMVTDSTTACTSEPYLHPAIITVLHKFFFHGRKLLGRCFQDTFSSMVDSDNAKEIPQAMLALVSVAIFAALKEWEQGLNESTSCEFVSANFSEQYDLHIMFLGMRILKTDGSGKGKYHALMAHLYREAVGANVSDADLAGAAKLPNLDFNGMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J908</accession>
    <name>A0AA38J908_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1139897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J908"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3729206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="278" mass="30504" checksum="915A08E00D66AFB3" modified="2024-01-24" version="1">MDVVITEDTLWMISNYASISGTTLWIADFIETLPTEINAIWQKKLTGASVLFLINRYSFLLSLIFGIPSSLPGNDDNKQLVIDILEQITSTGSSSAGTQFQSFSACVINVPDSNSHCGLDSLYMEFLSTPAIVQFVIPFIALVYDIYIFGLTMRKTIDLGFEMKRQGQSSVAHVIVQDVIDAILSGITLKTLTETAALFSTISSPIFNVLPNILISRLMLNLRTFHTSGTGNTLTTSQRAHFSSLHFASNQMLGNIGAPLDGGSFNEEEEELNEVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9Y1</accession>
    <name>A0AA38J9Y1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1155833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9Y1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="377"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="622" mass="67933" checksum="B51A8329BFADD772" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAQ1</accession>
    <name>A0AA38JAQ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1124092</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="464"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="693"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="1336"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2151"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="2166"/>
            <end position="2175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3723530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2175" mass="244542" checksum="953861436078BAC1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBW8</accession>
    <name>A0AA38JBW8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_171377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBW8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="910"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1272" mass="141201" checksum="6049B0C4A6D41DC0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC74</accession>
    <name>A0AA38JC74_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1063808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC74"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3734152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="210" mass="23139" checksum="FF24F5242009B22C" modified="2024-01-24" version="1">MSAPVATPVNVATGTIQPAPEDLNSPFILTNDKRPPILPWPNISGQAKWSVSSYKFGFGTECLLDGDPETFWHSDGPQPHFITIEFPRKVAIQKLSIFLCHPLDDSYTPSTLAIRAGTGPNDLQDVRIITLEKPDGWLTFDISSEPNEGGEGLKPVHAYILQLIILTNHMSGKDTHVRGLSVLGPIEEAVGEEDPFPWASTEFKMHETIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCF2</accession>
    <name>A0AA38JCF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1064508</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCF2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="802"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="826"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="141"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="602"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3734287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="848" mass="93804" checksum="6234498318CF54DF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCM0</accession>
    <name>A0AA38JCM0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1158485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCM0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="494" mass="55891" checksum="E6134C3052E4C008" modified="2024-01-24" version="1">MDNNSGGNDGQQRSALPRSLIPHLYSAPQTSRDSSTRTTLPEQEEEEDPESQAQQRSASPFALRSLPSEYPSQSPPLASRRYPPSYPVYDHLVQPSSEPEMRLPPTVPIRNHPSYYTSRAAHAYNFPQLENQQSYMTPPAWRQGEPGPSTIAQRGQFNVYRERQHSSRLPQDYRYADQYQQPQHRESYSRQDEQYPNYGAYTQGHPFPQHGMDTLLSSSQAHRQSSEHHIYVEDPTRSGHQHLYTLPPSGQQSGSVARGWDPPIASSSSTPVDYSSSSYLPLPPLPQSSRYSTEPEDDDGEYLPPGRRNQKRKLESSEQESGSRPKKTLIACDFCRGRKLRCDGTRPSCSNCRSRDNQPCMYQSHPRRRGPGKAPRGQRKKKAAATTSASERSRASNEGSQRYSTSGDDIEVDRLVPDFRSQQQQHLPPISILPYPGPTQGGMILASSSQVPQGETAYMTENQDQDRYQQRHFGREPRDPGVRLQPPYPDDAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCM3</accession>
    <name>A0AA38JCM3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_120328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCM3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="106" mass="11925" checksum="88CBA206A91CD796" modified="2024-01-24" version="1">MFSLSRRCLQRTVQIRRFAATSYVLNADATSTRGEQHIRAKLTEKFNPTSLQVQDISGGCGDFYAITIASDAFKGLPMVKQHRLVTETLKKEIEGIHGLQIQTRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD82</accession>
    <name>A0AA38JD82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1161221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000102">
        <property type="protein sequence ID" value="KAJ3713007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD82"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3713007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="227" mass="25063" checksum="9B7644DAE0CE3FD5" modified="2024-01-24" version="1">MPEPVREGSGPASTTGVAAAPAPTDPAQISPPKAIVVDRGGTILDIQLAESEEMNWIIWGGNLILEGLDFAVEHIRIVIKLADWERDSEKEGNISDAGTALLAEAKIYEYLAKVAPDFDITPHYYGVFNDSGSIALVLEDGGERLRRNSLKTLDDSEKHELFEKAQQLHRLGILHGDLTERNILMDEDKNFRLIDFHVSQLDHKCSWNGANGCGELEQFAEDLGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDJ8</accession>
    <name>A0AA38JDJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatase activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1146485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDJ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35823" checksum="52142B248764F52F" modified="2024-01-24" version="1">MATSSSPITQVSQTPAHVNLHQPQLLTRLLLDLRGKRYEVDRETIMNLPESVLLCLFPNGLVLSRQSAALDGGDEDEEDVYAVDFDPDCFQFVLSFFRNASEAFYGTATSPGLFSAQQHLLEAPPNDFSNPPPSQNPLISKQAIIVLREELEYFSIPPKDGSVKIDQNGIAGEALANIKRRCGDYLMEKKSIFTALQRNVNKENNVAEQHLIDMLCMSGFDREDEWGFRALEPSRCCISSIALVLLKTGITHHSGGDKAAEVDYPQMATAQKLLLFWRKPARKCWWDGLDIELPPSDDDGNRTIKLWARRVWTLELSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDK4</accession>
    <name>A0AA38JDK4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1104830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000096">
        <property type="protein sequence ID" value="KAJ3713770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDK4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3713770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="509" mass="57555" checksum="8B3925F3751218E6" modified="2024-01-24" version="1">MSNPASSLSEKKSVSDADETVLPHVGFDEVHEADYSEEQYRKLLKKIDWFLLPLMWVAYGVQQADKTGISTQALFNFRQDNHLVGQQYSWLSTIFYLSYLVFEFPMSYLMQRVSVGKTLSVLMFFWGIIVLCTAFAHNWAGLMVLRTLQGLFECTISPSFLLIIGTWYKTSEHASRSIIWGTANSGFGVIVSLCMYGIGDSATKHDSGLAAWKGISFFLGGTTILLSFFCWFLLGTPREVAWVSKEERRIAQARIVTNKTGTDHHNRREWKNDQILEAFLDPSTWFLFCSVVLAGLPNGGITSFGSLVYMSFGFTSLETILYDIPRQAMSIVWFLLVGYFCRFPNMRFWLMLFSIIPGFIGLLALALLPSSDSYRWIKFGMYFMTMTTNINGLLLWMHVPSNVGGRTKKSAVSSIMFIAYCVGNAGGSQFFRAADAPGYIPALVACSICLGLEFVFVLTWRIYLSYQNHMRDKAAEAQGLTPEQVKELGAENGEKDITDRKNPHFRYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDN5</accession>
    <name>A0AA38JDN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_115496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000125">
        <property type="protein sequence ID" value="KAJ3711092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDN5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3711092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="345" mass="36372" checksum="E6F02A4403DD7C0C" modified="2024-01-24" version="1">MPLEATMMVIDNSEYMRNGDYQPNRFDAQADAVNVVFQTKIDSNPENTVGIMSMAGKGPEVLVTHSKDIGQILKAIHTTSSKVGGAIDIPTAIAVAQLALKHRENKNLRQRIIVFVGSPLEGPAADEKGMVKLAKKLKKNNVAVDVVCFGDGIEEPVSGQEDQSVLKSFVENANSADNSHLVVVPPGPRLISDALISSPILSDDRSASIPTELGGTGGDGPGASSGGDFEFGVDPSLDPELAMALRISMQEAQAREAASSAEASSSNASQPTTSTVPAQSTEDEEEALLAQAIKMSSGEDVDMESSGTTKPSETDAAINEDDEDEEEAIARAIAMSMQQDEQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEK1</accession>
    <name>A0AA38JEK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1003162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEK1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="757" mass="80709" checksum="D3017F565F507887" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEP4</accession>
    <name>A0AA38JEP4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1067685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEP4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="246"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="248"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="397" mass="43463" checksum="BD450D7CEF018230" modified="2024-01-24" version="1">MSNSREDHYYPSLGKTGKNSSLSGDQGFFQTGQGGRTVLPPISSTFPSSHLPASSYTHQYTQPRSMPTRYDYNHALYNQWPGNNQSSAPMNYTYYDNNTSQNYYSTYPPSRTSPAVPEHGAESRKLPPLTTSSGLGRDDRWTSNTASYSVGPAENPSYSGIRSPTASYPLSFNAYPSTSATNHYGSVPLTDAPNQSHLVQTANHASMILPETHRPISPSYAPAGMQIPPSYTPPPVSPTTGTVNEPTIKKKRKRADAAQLKVLNETYARTAFPSTEERQALAKLLDMSARSVQIWFQNKRQSMRQTQTRQSSSSGASLHQSFGVSGSGEYDGHSTSGYETSASLHMPSSAYSVPRSSQESHSSSVLSPTVPHRRPRSQDPALTDTIGTKSQQWSPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEY6</accession>
    <name>A0AA38JEY6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_792760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000073">
        <property type="protein sequence ID" value="KAJ3717571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEY6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3717571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="464" mass="50479" checksum="8BEBE7EDD872AAF2" modified="2024-01-24" version="1">MSSPENTIVVPLSGIDQNGVHTSSITFGYVVAKVDVAALETAAKRAAEEWRLLAGRVEWNATKKSFQVKVPVSGPLPSNYPTVKFTTSKLPSTKLPVTPFDDHSATFLEKPPIKFFRHSSTLNSLADYASKKAPILSLHVSVLANCACVGLTLPHGIFDATGMGQVVKALNSCLNNLPWTPPKISSSNILAEELKRLRESESIGDPCPPGLVNLQRDFTSVNVKNVLTLGASCATELLWHRVKPAAIYLGSRVVEEMVANVKKQAADEGKGWVSTGDVLVAFLLKAAYLDEGPASPNALTLSTAVSLRGILAHENRDFETYSHNALLPLAFPPLTVQQVSSMSLYEFSLIHRNAIEDMRNIPYIQGYEKWVPSIGGAAIPARRKGTDSWLLSNQVIGGVDKLDLGSEPLGFWHWMLPFMPDHVFTVNKLRGGYILDGFSGVRPPRLRAIEKALDGIRKGQPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFN7</accession>
    <name>A0AA38JFN7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plus-3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1002078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFN7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="217"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3726508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="553" mass="62281" checksum="64BC3574927AEC88" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGB5</accession>
    <name>A0AA38JGB5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1154797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGB5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="97" mass="10517" checksum="2506CE60B21BB313" modified="2024-01-24" version="1">MSSFVVLAIAIGDEPLYNDDAGSPAALASYFTERTYGRALETLLLWADAVNNFPYFAFEATTGGNASTSWNSFIQGIDYLESIANGRPILVTQLQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGG2</accession>
    <name>A0AA38JGG2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_417236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="373"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1380"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1542" mass="170067" checksum="5B02F7D62EA73DB8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGN4</accession>
    <name>A0AA38JGN4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1074233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGN4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="580" mass="62658" checksum="EDA7009F0EE58B2C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGU0</accession>
    <name>A0AA38JGU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1058411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGU0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="172" mass="18826" checksum="B077E82C664A2F66" modified="2024-01-24" version="1" fragment="single">LHDPTMTGRNLGTSHTPSPPSNSYAMDVDATHTSGNSRESFVVQMRGRCYGCGAQNHEKKNCSYKDTVCRYCGRRGHLESVCQDKFMGLERGRGKRSQPRRQQVSASSSIPFTLFPNESVQIATSARSCSCSRSCSADSAQPRSLYPDRSTAGTPEQSKRHGLSVWIAGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGU6</accession>
    <name>A0AA38JGU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LIM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1077703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="166"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="229"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1258"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="801"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1294"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1312"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1350"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1375"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1394" mass="153206" checksum="9532E85E71A5C574" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGV5</accession>
    <name>A0AA38JGV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_448948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGV5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041444347" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="192" mass="21211" checksum="7691216AE87FCFDA" modified="2024-01-24" version="1">MRSFLWLTFLLLNLTQNTLCILINVTVDDNDHSILYSPAGAWNARNAASSCPACTAQPDPTKMVSGTWHDSTFYPIDEGTHDIPNINTPRFANLTFNGSAVYVFCALAESVKSPDGNSDMAFYVDGQLMGHFFRPALGNDNIYEYQFPVFSNNSLAPGEHTLVLQNGRVNGTQSLVLLDYIVYTYVLIDTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI38</accession>
    <name>A0AA38JI38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_374122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI38"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967:SF2">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041264566" description="Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="395"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="49872" checksum="0886FFADA3808CFF" modified="2024-01-24" version="1">MLNLLALPISLLFIAHGARATSCSTAQLSNGYYNVNDSCIQCPAGSYCRNNEKFDCSPGTYNPDIGSSSSITCSSCPLGTSNPKPGSSSPSDCTPCTPGSFSSSLGAMQCTSCPAGTSNPNSGSISSSSCSTCGAGYYSDIGAGKCSVCPAGHYCSGGDKFACPAGTFNAFTGSMNSFACTICPVGSVSSPGASQCHECPSGTFEIGDNKQCKTCSAGTFSNSGSSSCSECTQGTYQPNPGQSHCISASPGHFVPSPKSTTQTACEAGSAQPLSGQTSCDLCAPGFFQSQSGQVSCCQCCAGFYSSNFGSKTCNQCGAQGTQSRGTSQPGSTSANACMAGSNPQPVKTCIQPSADACPVVIAKAPSKRSPSQLHADFCSISVPRRHWCKVLNGGMECVDTMNDLEMCGGCLEPGHLEDPTTGARDCSAIDGVGDVRCRQGQCEIQSCHKGYEISRDGRNCVRVKIADIHRHLSHASSKGRGWEVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI55</accession>
    <name>A0AA38JI55_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1003095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI55"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3724297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="247" mass="27747" checksum="777F2EA80DAC35EC" modified="2024-01-24" version="1">MPINQPSNQIKLTNVSIVRLKKGGKRFEIACYKNKVQEWRNGVETNIDDVLQISNVFMNVSKGEVAKHGELKKAFGTTETSEIVSEILKKGEVQVGEKEREHDQSALRKEIATLVAEKCVDPATQRPYPVGMIEKAMTEAGYSLKPNKNAKSQVSDCIKILQSDSTLPIQRARMRVRVTMPIADGKRLREEVLEGAEKVEEDEMGQNEWEVIMLIDPGQFRVINELLQKECKGKGRIETMTFAATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIJ9</accession>
    <name>A0AA38JIJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_438565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIJ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29448" checksum="EC792F787AF3524C" modified="2024-01-24" version="1">MNVLAIGASRNIGYYASLRLLDAGCNVVFMLRSPSIFDSDNAIQTYVQSGKAHLLKGDALVQSDVKHAWEETLTHGAVDLVLFSVGGTPSFSVTKGFVISPANLVTHSLMNVLCTISTQSPQPKLVTISSAGLTPSSHAQIPLLLKPIYLLLNIPHKDKMGAERAISHIAGWPWPESNGEPELDIMGEGWMEKEGLPAAGTYQNVLVIRPALLTDGECKADKAREGKVGYRVKDGDFVAWTVSRKDVAHFVADAVLNRWTEYQNKCVSIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIT1</accession>
    <name>A0AA38JIT1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp70 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1187414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIT1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="625" mass="65867" checksum="25777762203330A3" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ71</accession>
    <name>A0AA38JJ71_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1132240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ71"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26536" checksum="C11622127BF0EA99" modified="2024-01-24" version="1">MFARFPSRLAHTSTRLSANASRTSGLIIRNSRSFSVLANSAVKTSSIRKRYASSTTPHSTASDPAEIEAINCLEQGTRLLEEGDVEGAKRLYARSAEINRNASSLYNLGVTYYHLKDFDAAITSWQESIALQPSSPDAHTNLANAYILSPLPRPDLALHHLRFVHCVDTLLVSLTPEDPEIAFNLAAVLEATENLEESLEYYKKCEAYGIERAKMHIRNVTAKLLARRVQSVQSSGQSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKJ9</accession>
    <name>A0AA38JKJ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_270716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKJ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="259" mass="28472" checksum="CA4222F171B40BBF" modified="2024-01-24" version="1">MSSAYARQLFRSCSASLSSRTLARPLTSNFSSRPASFNLRRGYSETKSTSEPAEEQKQDESSEESVKESHPDTEKLKAKEAEVVDLTGRLRYLQADFLNLQRNAAREKEQTRDFAITRFASDLLETVDVLALALKSVPTSALSAETTSASAETSSGSSSSSLSSSTDTSPPKSAHAYLQELHTGVEMTQRQLLQTLFKYHVKPFDPTGDKFDPNRHEALYQAPIPGKEPGTVLDCQKPGYMIKDRVLRAAQVGVVQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKQ5</accession>
    <name>A0AA38JKQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1152185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKQ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="238" mass="26282" checksum="E6DE16C617890D8D" modified="2024-01-24" version="1">MSSSKGRDFTNRAKTHTVNPMTKWVSRLALGIVLIATCFLLDAVKHRWYVLDPASLHELAQAAIASSPNNTAGMVEHIVSNLTATYPSSVIALNTNSKEWVFNNAGGAMGAMYIIHASITEYLIIFGTPLGTEGHTGLHTADDYFNILVGEQWAFSPGQLEMERYPPGSVHHLPRGTAKQYKMHEGCFALEYARGWIPLMLPFGFADTLTSTLDIPTLYRTIIVTGREILRNLFIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKR0</accession>
    <name>A0AA38JKR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1046337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKR0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="527" mass="57537" checksum="08C2580C45964779" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLW3</accession>
    <name>A0AA38JLW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1059686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLW3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="242" mass="27863" checksum="5D30CB7EECBC03EF" modified="2024-01-24" version="1">MDNAWQPQDNDPSNSADGISIPTRDVGPADYSNGNGAPPRSSRSRSPGDRGRTGGEGGVESDNPGNNLHVSGLHSKVDSRDLESAFAKIGRVAKASVVYDPHTRESRLFGFVTMETLEEADAAITAMNATELMGKVITVIRARRGRARTPTPGKYHGPSKRRDRERPYDPRPYDSRYARDYDDRRSSRSSRYDDYRGSSRREYRDDRDRDRDRYRDRDHDRYDRDRYDRGSRHDDRDRDRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JME8</accession>
    <name>A0AA38JME8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1138019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JME8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="100378" checksum="69352792C7F72467" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNG9</accession>
    <name>A0AA38JNG9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1057855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNG9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041211548" evidence="2">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="143" mass="15829" checksum="55BA9B8E9200DE19" modified="2024-01-24" version="1">MGNLLWFFLGAGAATMYAKRRNHLEHEGRCSHPHSARNISSSPEIDQPASTQKNTFIPSAPWNSHSASVASPASGHDSILSSDPWAVEKERIREIGSQVGDNVLDFSESTLDTLLSNIAGMKAKIVQQRLDRERHEQNPLRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JP42</accession>
    <name>A0AA38JP42_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_431203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JP42"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="56"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="410" mass="45376" checksum="B6F1D49E02F89CE6" modified="2024-01-24" version="1">MPAEPGTSMSKVQRRTYVYKTLHSPGDEHIPVLLDIYLPPLVSDVATGDSLTLGALVYFHGGGLTVGNRMSWFPTWLQKRITDAGHIFISPDYRLIPSGSTTGHDILEDVEDVFKFVAKLSNDVTPEQSELNPRPVQFRVDPERIAVSGSSAGGLCAYLAAMHATPKPKAVLSMYGMGGNFLISNYYTLKHSVFFRGREILDPTLFSDFLYPACLSLSSQVITGSPNTYFPPDAPTDVIAKPGLETNSGPPGFPSNRRMFLARLYLQLGEFLDYYTGEFEPSVSASLRTKAEDMQSTSSLSDRGLEDNLAEVIPEKHRSLFPSLCSPHAYASWPPVYFFHGSLDSAVHIRESQRLHDLLTEAGVQSVLNIAQGMEHSFDYQPDADAIHGQEFNKIGRWLDEFLTDTKIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPM0</accession>
    <name>A0AA38JPM0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_709507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPM0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="50337" checksum="BC3E5FA875AE29EC" modified="2024-01-24" version="1">MGGSRFVESHSSSRHTPRASNCFAADPIDTLTDRMNVALNSSGQGYVLSLCPNTEYSIQAPILFAFSDQEISTQGYPTDASRALIIVNGTVNNGTGQTTAIDGTCAQCDGVRLRNVQINGSRNGGSPVNGGGNVEMGGSNSNQLVEYVKSYNPRGWTCLHIVEGALSCNNITVQNNDVGPCGTDAFQQWADGLSISCQNAVVRNNMVQNPTDGGIVLFGSPGTQVYNNTIWVVNQTLLGGINMVDYNPWSGDYTNTVVYNNTILGGFSNENEEANETDGTNSDDVIIKIGIAIGPRTWFGTEYGNNVSLSGRVYNNRLSGAFSYAIGMTSAKNFTVENNVLFGNTSFIGARGPNCSSSDTTPTPAAFVIDLNTVIQSTTQSNFTTISDGNSLTCVQPPDGGDYWPFGGNPSTSTPSSPSSGHSSSSTAGIVVGVIVGILLVAVIAFFIRRWVLKRAEAQRLYKDSRRSRYIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRI8</accession>
    <name>A0AA38JRI8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_183467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRI8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="77" mass="9070" checksum="4030F28636217C12" modified="2024-01-24" version="1">MSLLLFIISPLCSLYIPVLDFLTVSKTVASHCSRVSEAPYRDKEVRLRFTYTFCINIRIFITTCIRNRINTFIHFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSA8</accession>
    <name>A0AA38JSA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1112572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSA8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="375" mass="44037" checksum="57B8A255BC92CC65" modified="2024-01-24" version="1">MNDNYRYFEEVIGPLRQNRRFDPGALSENEEWWSGHYEFLKERGYMLRPRYRPGWKPSYDPKGPFRGTRAEDGQTMLHAAIMDALRTSDSLVVAMKRIEISTDEDQIATIFSDDSHNSDPRNHCVRIVEVLLVPEGDEKILVMEWMRRVMNPRFRTVGEAVQFLKEMVEGLQYMHQHNVAHRDCSINNMAMEANAMYTRPYHPIRPKKRYDWSGRALHHSRTRCPPRYYLIDFDQSRMYDPSQPRPKEYALKSGGYTPPEGSEGTPCDPFATDVFLLGNLIRTSFLDVFHGFEFLRPLVEDMIMDDPSERPSMDEVALRFFDIIDKLPWWKLRARAVKKDEFPLAKPFRALYHVFWTASMMLLLKPAIPSPKPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTH0</accession>
    <name>A0AA38JTH0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein L23/L15e core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1054929</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTH0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_uL23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3735905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="163" mass="18173" checksum="C5A7B56F4F42D6EA" modified="2024-01-24" version="1">MSTTKTSKGKAAAPKASKSTANTKDSKAKAAKKAALQGVHSHSSRKTRFSVSFHRPKTLRLPRDPKYPRKSVPHVPRMDQFRTIVSPLNTESAMKKIEEHNTLVFIVDIKSNKRQIKDAVKKLYDVQAAKVNTLIRPDGKKKAYVRLTADHDALDVANKIGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTR4</accession>
    <name>A0AA38JTR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prephenate dehydratase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1049348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTR4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="279" mass="31115" checksum="D152772F1BCB4E4A" modified="2024-01-24" version="1">MKVRVGFLGPLGTYTHQAAHEYFQDSVIYNERKTIAETLESLETLDYAVVPRENSIFGSVIETFDGLKVLKRGSIQDEVVLKIQHCLVVKKGARLSDIDCVISHEQALGQCQKFLAERLPSATTTGMISTAAAAQKVSKSQTLNVAAICSEICVTTFENLEILVRGIQDQNSNYTRFFVLGRNPDINPSFTHALLRVTPQRGCTDSDTTFDLTELLKTIDLSVIHIDRRPAPVSEPFLDTYFLEVVSSSKKASEWPEQLSQSISRVRGKGYLVEIIGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUI7</accession>
    <name>A0AA38JUI7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1046147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24409" checksum="AE8AAE39F43CD58A" modified="2024-01-24" version="1">MTRGRKKDLSIPPTRALTQQRDYRARKAYYLAELEERCHRVEEENARLKQEIQTLRAGLPIENTPVDPRLLAASSDLMRDLSAVSNALESFQQLAYPQTSIMHSHLTPRASPSPSMSSSSSLSSSSRLRPAFFPSPPSSEESLPLQDVLVGQEKCDIWLEEGSHRPAPESHSLRKILCLPPSDATTQPNGDLNRTPIPTLPTDSNIAAHHTVTPSEMLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZD4</accession>
    <name>A0AA38JZD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1057038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZD4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="34"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3735788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="156" mass="18135" checksum="C2E1ECE7C1853E64" modified="2024-01-24" version="1">MTTVSPFARANTFDDVRMSGREQTIEEMYSVPESFLEIEVRNPQTHGFGRKMYTDYEIVCKTNIPAFKLRHSAVRRRYSDFEAFRDILERESTRVNIPPLPGKVFTNRFSDEVIESRREGLERFLSIVAGHPLLQTGSKVLCAFLQDPAWDKAQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZR6</accession>
    <name>A0AA38JZR6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1150342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZR6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="204"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3736043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="550" mass="61680" checksum="96984BFBE079F349" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZV2</accession>
    <name>A0AA38JZV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1221266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041255307" evidence="2">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="208" mass="23428" checksum="F2BC9C45904562F3" modified="2024-01-24" version="1">MRFNALIWAYLVLQLVSAVYAAPRFDPRAPAGEEASSSKRKGSEDDGSAKRIKIENPSVKEESPGVRVKKESHSPDIGEDRSRVEFSYVEEGKFKGRVHKVSLGEYSKHWMETLVKQTAREKWGWTEGRVESLLFDYPESNPEHWGATIKWFFFKGPFQDCGLKENGCLGEVNVITHSGSVYKRGGRNGNGKGDLVHYVDKLDISFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSK5</accession>
    <name>A0AA38MSK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1001558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3727999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSK5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3727999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="159" mass="16923" checksum="F54508F9C5BAA108" modified="2024-01-24" version="1">MWLSSKSLAFFASLPILISATTPRINEPANGTVITPGAAFNFSYLSIADYGTTAYNYTVWLLTSLPSSTAPSIQFASGYDLGKYAEPNYPGNPSPSNPPPAQLRMPDFSQPLGGFGDGYSLSNATFYIAVVEEYGVTNPTGPGRLLSVVMNSVLYNVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTU0</accession>
    <name>A0AA38MTU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000142">
        <property type="protein sequence ID" value="KAJ3710252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTU0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="490" mass="54950" checksum="E15455889995193D" modified="2024-01-24" version="1">MSTDAYVELPSAMAKESPQRQQPPNKNPRLNGSQSAHRTPDISSPNKANRKIPIQRNAPLSESDDEMGQPVTGEITPDTRYNPHTDPENASMHEQTNEEDVFSVRTQALGTTIHTRGDAEPGPTPTQTGEENGDEVGLRAQKTTLLTNSDEENPRPNTRILRSIARTPMPILTIVTVGTFEEEQNREVFGDGENPHGHIAEPEIIASEGMAKILRYCSPDEGQFIRDTFYPSYIFQGITEDRVTMYCAPENKFLALVFFNGGNALHTKYTKMVFELIDFLKKIDCKEDEIQVNAPFYQRPAIEPPHDNAKRGGRSRGGRSDKPSRKVIRGGVSPAGYSNDDDRYKGPNTAFILLESSNIRKRLMRLQTIAVSKTLTFHAFAPSTTQRPWTVCLLFATTTKTDTYIRAGIRWAIRKAIRDDHAILDKITEYSGTMGTAQQRAQHFINTIELYYAGYQATKEGQKCGVWVLYAAPFATGDTYTEIDLREQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTV1</accession>
    <name>A0AA38MTV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000133">
        <property type="protein sequence ID" value="KAJ3710761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTV1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38239" checksum="F8DB222FB4AE4F3C" modified="2024-01-24" version="1">MPAFRYSPEAGSMNFPTSSTTSRKSRRAKKKAEGYIPRPPNAFILFRQNFVRNVYQAGTLNTTISLWVKSSAINGHLLIKFLFCPKHKKRRASSDSTSMSTDDASSTTASSRCDRPQSVIKMVRQGGVKRQKHPSDISKRPSSRPYARPPWYSSIRHSDRSDWDSAQGSIAGSCKGHPSNLASTSNLAAPVQDSPREGCNPSSSSPPRFGVDSNLPPNQDLYCPLENNLNTGSESSFNDLLYAIYRDHDLQQPFDSPYLLGSLDSRQSSATSFDVSDGPGHSSLANVDSEVSSQSFVSAMEDYSTHTPQSQAHRQRNDQSWQSLLDIGKDSSFPTPSSRLFGQWSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUD9</accession>
    <name>A0AA38MUD9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_284284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUD9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="520" mass="57389" checksum="F825B38F71A90FFF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUT9</accession>
    <name>A0AA38MUT9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1175332</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUT9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="291"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="956"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="965"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3733634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="993" mass="108466" checksum="6D7167430A73E0F9" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUU0</accession>
    <name>A0AA38MUU0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1104117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUU0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="80"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="248" mass="28182" checksum="E6543AE1069E754B" modified="2024-01-24" version="1">MSGQNMKTFESPEVLKYVESIRAAATPERPALASDRGRWAMAWLHLVIWNSWKSSYFYADKFPEDDLQNYLEYALLSATFLAEHHDAEESALFPALEKKIPGSMEQNEAQHQSFLKPLEELIEYINLAKAEGKIDVATYRGKVDPIVAPIMQHLAEELDSLEGSKLLEHFSESELDAINKATHKAQQGDTHKMLPFVLQNLPPGSPFPPAPGFVKTLLGPWVFYWKYSQLWKYTTYPMKPVLTAAPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV98</accession>
    <name>A0AA38MV98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_993764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 8"/>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV98"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00570">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003704">
        <property type="entry name" value="PRK05321.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="170"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3734189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="406" mass="45878" checksum="FAE6330732FCF5B3" modified="2024-01-24" version="1">MALPILKSILDTDLYKFTMQNAVFQNFPDVHAIYRFTNRNKDTTLFSRECFERFQTAVSQFGQAKLTSTERAWLAQTCPFFPSQYLDYLENYRFKPEQVHAEFVLVDGDKGHIEITAEGLWVETILWEVPLMACLSEIYFATVDKDWSYDGQEELAYQKGKALLEAGCVFSEFGTRRRRSFHTQDYVVRALLKATQDVPDSGKLTGTSNVLLAQKYGISPIGTVAHEWFMGIGALRGYEHVHDLALEIWETAYPNATLLALTDTFSSAAFFQSFSKNPARAKKWHGLRQDSGDPLEFAPRAKEVYEKMGIDHKEKMIIYSDALNLDKALKLKKQADEIASFGIGTFLSNDFVKASDSSSKSPALNMVIKLAAVNGKSCVKISDDLTKNTGDKEVVKEVKELFRLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVB6</accession>
    <name>A0AA38MVB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSF1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1228130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000093">
        <property type="protein sequence ID" value="KAJ3714027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVB6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="214" mass="24164" checksum="C0DE622E4F74E274" modified="2024-01-24" version="1">MKYHSQSFFYDDPWSIVSLAYFLRYPNPYASHIISCDVISRNVTASGTLQTTRLILKRGSLPRWAPKGIISRAESWVLEESEVDPLGKTLRCTTKNLEYTKVMKMEESVFIRQTEDGQTAQTTEARVLSGFGWGLTKRIESHGLNKFKAHVQRSREGVSLILSLLRESRLQPMTLGGEPSQLNVDPTIQESETISKAQNGTWARLKGWVSTPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVP9</accession>
    <name>A0AA38MVP9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase family group 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_849449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVP9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="916"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="47"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="685"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3715235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1071" mass="119882" checksum="318D02CC2C274C86" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWI8</accession>
    <name>A0AA38MWI8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1096034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWI8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="124"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3720189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="39906" checksum="AC35F11539424B93" modified="2024-01-24" version="1">MNEGYKSDISSTVDASMLFESEDEGPNSEMAPPKIVSRGQSTKRQKLAQDIKYNAERPSMVNLSAAGVEVSSSSRNDLEESSNAGWPAVTHLVYPIHSRCISVNSQSQMIKDLLKEAILLAVGLAIFQDGFATSDVQVTHSRTSITSAGAKQELPEILHRFEQDRRYAKFLTDYVTGRVGTMRKKLKETAADLVPSLYGIHQASFEDGSRKQLVETLLSQLNYIFPRTKITDASTARYNEPYRHPALVAVIHRYFFAGKKPLGHRFRATFTSSIKTDDAKEIPKAMLGLAAVAIYDSLKEWVKGEGNRVKKDFDSESISGEYDRHMKLINEKIIKADGSGQRKYHTLMSRLYQDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWS1</accession>
    <name>A0AA38MWS1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1097136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWS1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041307167" evidence="2">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3719595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="349" mass="37309" checksum="077EA1A1D446B8D9" modified="2024-01-24" version="1">MMRRAITFAFVAILALQTSAAVISNARAVSLSLDGRQSVDPNTMLEVRGFMDKLKGLKEKIKPKKAKLPVPEQGKSENIRPADTPNESKHSLNDGDNPPKPKHGKQRKMGPLAVEGENPPENPDMSPPNDTSKAVDSSDEPASPPKTATSKGPSHHHHHRPHRESTSNANPGKDSEVTLKPSRQRGSTVTGTGNPKPNMQRVNSGDSDYAVTISSEQSGTAGTKNDVLSPPHTHRHGHHRGPSVSSQQSIDSNKLGRTASSASRGRGRPGSMHSQKPVDKSRSRADEEQKAKDRAEQRLSALYVQQTAQQAAQTAQTDAARQANAANVYAVTGNTAATNPGMMKPPGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX75</accession>
    <name>A0AA38MX75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CTD kinase subunit gamma CTK3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1003350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="271" mass="30914" checksum="1A098D538BE597EC" modified="2024-01-24" version="1">MDPFEVRMQFVALLRRLDASQQSIRKVVSYAVKFFPPCGEDLWDCIVEETQKGSINSRINILYFLDSLCETCLLVKTHANAIGNTQKASSNMYVDLVARDLGKIVGNVVPPGVEGSPNLVSTKQILETWRSKRVIDPQILDSVITSFAHRNDAGESDNDAPTVRKTFAPLPRSEVFKRIEEDRERHKRLRERRWVQPITHNNITQMQAPPLASFMPLTEKEDGDRELSIDIEFDNEWETLSDWNEDDDEACTEENALCFPDPPGEMAMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXK6</accession>
    <name>A0AA38MXK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_578066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXK6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="282" mass="32249" checksum="4A59A63E0FF7DF0F" modified="2024-01-24" version="1">MSASELFDTDLSLPSILTQLAEQTLTSQQPQSGSNLAWSPTTSFLVGVLVLTICARRAWRYYLRASNTFPSSPQDVHCYHLHEGGPWPWICITMRELSERAEEVNTELVRLRMLTISDAESSLGIQVARTRPTSSSAGFSLGQGSRSGYLDMVERWKIIMEYEERMMRIQETILDLSLEMHHIQGSTPTTTPLVPSIQGKTTIDAAQPIFGFSPNPLASIRRVLLNCNNNHVGRLRRIIKCYRKMMELRKEIHITEQKSRREQIRWSLQILKLRRASTVELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXL2</accession>
    <name>A0AA38MXL2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXL2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="64798" checksum="1F22DC7ABDBBC6E2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXX2</accession>
    <name>A0AA38MXX2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1001997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXX2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="211" mass="23414" checksum="935A7D36865C7E8E" modified="2024-01-24" version="1" fragment="single">MYVERYIQTNGNFDEPFGIADTFISRLRPVLHVANFSKAPITIAQGQLLGHARNPSKWLTKSSEMSPNQNNAVQAHCSFVRKLIQQGSHKHLTSSHTVRSESEITSKAHRNIIEPDDPLAEDPIEGGPKTAETGIDFVSSEKLLSEVHISTDLTQEQQQKIEEVMIQNQRAFGLDGRLGNYEAKVDISMKPGTKPISLPPYSASPANREVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXX4</accession>
    <name>A0AA38MXX4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1192132</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXX4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="14">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="13">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="415"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3728106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="729" mass="79329" checksum="FE39057E64802A8B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYU8</accession>
    <name>A0AA38MYU8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GRASP55/65 PDZ-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_439992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3730981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYU8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="127"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3730981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="358" mass="39706" checksum="9155722484821277" modified="2024-01-24" version="1">MGASQSTSEVHPPSQALHVLRVTPSSPASQTNIEPFFDFIVGFEGDSLSSHSNIDVNELETFVESHEGRVLNLLVWNSKSEDTRVVSIIPSRKWSQLSPEELQTDIHAQPSLLGLSMRMCAPEYANNVWHVLDVSEGSPAEDAGLVPYGDYIIGWSGGVLSAENDFYDLVEAHIDKPLRVYVYSHDFDALREVVLIPNRHWGGEGLLGCVFGFGLLHRIPPPNPDHIPGSTPPELAEEDDYHTGELFVPADVHMESKISRVTKWRDQENPNRETVSSLPVHVKPSSSTELEPWLESSGPETAVPDFATSDRYQVDKEDEDYISPSQETPRRLSPLSHVTDVPPTNLKRSLNSTLTNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYV4</accession>
    <name>A0AA38MYV4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fcf2 pre-rRNA processing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_442379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYV4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="165"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="293" mass="32827" checksum="15AF9023C9AB98F1" modified="2024-01-24" version="1">MITQEYLDSLLEKARQNAALLEEKEKEEARTQQDKEDVLTLEKIDSQPPLPPLNPGILPRSYFNFTSGSSSQAEIKTQDDSEPSSSGILNSLSRDPLAEIAESALAKAASTASSPLEFHDGKDLTKKQRKEVGSITCSQDFSYLALSSFLLCSTYSTPSITQLKPKTAGPDWFDLPAPSESDLPRLYREVEALRLRNQLDPKRFYRKEEGEGKGIKGLPKHFAIGKIITTDTPFGGASGDNLTRAERKRTLVDELVDDAEMKRYAKRKFEDFQKVRGARGKNTKNVRKQKPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ41</accession>
    <name>A0AA38MZ41_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1155773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ41"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="370" mass="40456" checksum="E50A09CA5A6BED6D" modified="2024-01-24" version="1">MAPPRPPFGTDEPESIYETPNHPQRRIRQPAPVDPNSRTSAYNVYNTYLHDDTNRQSGIDALGAGFMNGSMDDDDDELEEKYNPFTSAKEKEASKQAMLAAAISPRKTPTPPPQYIASPRPGYAAPIEALSRPEPAAVPAIRQSPNGLSINTSNNPFATPMDRQAFPGGPHIPQPIAVPSTPHPLQPPMTPITPVFARPRQQDVHFDEKPIMRGAGEGTSIPSRGEKGDDFWRRFSVVVKEQNSKPAQLKQSSWLKTTQGRTNSMFRWVFFIGMILAVCALGAIGLWWYASHNSTAHDQPQALGGSEKESGSSSTVGVASSAATLQASLHVSPTNTVARRILDEVYEPQPTGLSSSNKRHKRVLHLNRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ51</accession>
    <name>A0AA38MZ51_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1040301</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1146"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="597"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="671"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="762"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="871"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="949"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="981"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3731296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1304" mass="144726" checksum="4A7D3DC7F119B00C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZI7</accession>
    <name>A0AA38MZI7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1190239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1089" mass="122878" checksum="676DD554EEC46742" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZS3</accession>
    <name>A0AA38MZS3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_997810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZS3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="51"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="269" mass="29749" checksum="56CF6D1C36E256A2" modified="2024-01-24" version="1">MRYYNVAPHSFGFSPYFHLNRPLTRRSLRAIRDGLNSAQRLDDQIPTETATGKAAVLIPFANVIDVPGILLEVRGTAMRSHSGEVSFPGGRVDDTDETYVDAALRETREELGIGAHNIEVLGQIGPPEVNLRGNMVVYPFVGFVHANSSLSDHNLADDEPLPSCDLNTIRKNVSQAEVATVFHLPLSALASPDRLRASLFRGHRPYWTVGVQDLVPDMAPSPTFEHPSQSGSDNVDDSEIGAGKYGNLEVWGLTGWYLYLLMKRLKLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZZ6</accession>
    <name>A0AA38MZZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1080814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZZ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="139" mass="14863" checksum="D45A1D067456B0C5" modified="2024-01-24" version="1">MSVIGVSSQAASSNTAFNSQPNGVTSSTSSASVGMTPELEQTLALLSSHRSVLGYMLLSRGHPVSIIRHTGGVFDGEHGKKYAGVIARIVETVQSGLEEINGSENEGDDVKFLRIRTKRHELMISPDGRYLLAVLHEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0C5</accession>
    <name>A0AA38N0C5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_996676</name>
        <name evidence="9" type="ORF">DFJ43DRAFT_998500</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0C5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3731852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3732737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="103" mass="11217" checksum="8B8499DE66DFAB41" modified="2024-01-24" version="1" fragment="single">VAGLIFYATFSYLWTSQVIANVALATLAGGPYGAWYYFGPKEMGEMPNHPTLSAFGRASTLSLGSIAFGSSIVTLLELFVGCIESAVEYFNRLVFMFVFVSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0R8</accession>
    <name>A0AA38N0R8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1153560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3733200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1627" mass="179755" checksum="389AEE34905701A3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1C9</accession>
    <name>A0AA38N1C9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1774-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_190535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1C9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30436" checksum="0B5C3AB766E9B896" modified="2024-01-24" version="1">MADSWTDGILLKIINVIVYVLFLGSNIYTVAAPSDIYWTGKETYITPAPWAFLIWTVIHILLLGTVIYQFFPTGKRVIIDGISWRLPLLGVLNAIYVNLWARHSYIAAFVFALFVSSAVTHIYYVVKKHHASQSVADELFVHLPFSLYHGWTTVLVILTVFEAFGNNALHEKAGVWTKVLVFLSLFFLEATSATYAFSTPEGDLPASIAICWSLFAIFAHQRSTGFIHWSALAFSILSLVWVLKGSYGLFVRSRGSGGIRLEDPERAPLVGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1U5</accession>
    <name>A0AA38N1U5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1068664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1U5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="939" mass="104821" checksum="76D1190D3CA7480E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N217</accession>
    <name>A0AA38N217_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">DFJ43DRAFT_993353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N217"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="339" mass="37367" checksum="DE3FA7069DE1CF74" modified="2024-01-24" version="1">MICTGHEDRAWHIAWNPTKSLLASCSADKSVKLFTYNHDGEGNLNFTLATSIPTGHLKTVRAVAWSPSGRTLATASFDSNIGIWEQELDDDGNPGEWECASLLEGHETECKSVAYSSSGNLLASCSRDKTVWVWEVQPDSDFECMGVLMEHTQDVKCVAWHPTEEILASGSYDDTIKLYVDDPMDDWFCCATLTGHASTVWSISWSPNGKYLASASDDKTVRIWRRIGEHEFKCVLVLEGHERSVYSVSWGIGKSNQEIDSSLGWIASASGDGVIRVWDLSNSSTEPMIPSAKLIARLPTAHGVHDINSVVWCPRKGHEDLLATSGDDGMVKVWRIQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2I4</accession>
    <name>A0AA38N2I4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_994523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2I4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="161" mass="18300" checksum="D45B7C92844E2F3D" modified="2024-01-24" version="1">MEEIPGVQLKEVIDTFTPLQLEDVASQIKGLLTEMRSIAAPHIGSVSGGPFRNNYFFPYAIKPQHAWTKLLASFPQDCPIYFSHGDLVPRNILVEGSTITGIVDWSMAGFYPEFWEYCRMYDESEESKGWTQVLSMIFPGPRHDIQIASLHRLMGTLLYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3L0</accession>
    <name>A0AA38N3L0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_990200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3L0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="420" mass="44701" checksum="394885064195F690" modified="2024-01-24" version="1">MQALRESQAAQAGSNFTTVVGGSDFDEEYLTNVTFGEQDFLLIVDTGSSDTWAPQIGFACFDLDNNPVPQSQCAFGTSGYDTNASTTFVADPDTNFNIEYGDGEFLTGTVGFDTVTVANMVVTNQEIGVVTNAAWEGDGFDTGLMGLASPNLTSVFKGTNPDDDEFPQTQIPYNPVFYSAVQQGVVSNPFFSVALDRGSFAAQNSSDLDQNLGFIAFGGIAPVDVTDTAVTVPVQGYNAASFLPENGSSVTYFYYTVDVESMSFTGNDKVFGTTNNIILDTGTTLDYVPTQVADAFAAAFDPPAVKNEDFGVYEVVCSATVPEFTVDIGGVTFTVDPADNLLPLGIQDDEGNDLCASGTFDGGPAEEGNIFILGDTFLHNVVVTFNIETDEVTLTQRTPYTNGGTGARRRSPESLRRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3S5</accession>
    <name>A0AA38N3S5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_989932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3S5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="212"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3736321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="530" mass="58881" checksum="6D8506255B59E8A2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3Z5</accession>
    <name>A0AA38N3Z5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_966361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3Z5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12254" checksum="3F153E5766CC13FB" modified="2024-01-24" version="1" fragment="single">LRLRHQGLLNYTEKLSALLSPIRRLADNILSLIFVLCCEDNMLTHNWRYAHTLTISSVCPRWRQLAISNPALRSNLTIDSQDDNDHTESVLALYLTRSKTYSLSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3Z8</accession>
    <name>A0AA38N3Z8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3Z8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="175" mass="19080" checksum="114B3F2CE7F497C9" modified="2024-01-24" version="1">MAFSTLSTSETPTLPPLRPVATPMPIRLPGIEHIHSLPKSRPSCTIPLYAPRASVPIPRKFSTSSSITNESRSPSPSPSNSSFISPSCTSQTSTQRGQPFMRLVPTDMAHAEAVVVVPPPGPEPQKPLLLIGPALKMVNHPQRRIARGARVYPYRREMNHHSRKASWASTNCSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4C0</accession>
    <name>A0AA38N4C0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 76 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1211423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4C0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="381" mass="40670" checksum="6DECAE5097F77DA0" modified="2024-01-24" version="1">MFASTTCLVMLTSILSVHAASVSHQHQKRAQCAAILTTAESVASTLQAHYYDTGTGMYNGGSLWTDANALEDLHNLMLGADVDTWSTVADGSYIGKAALSSSTNWASLLGGANDDAGWVLMALWKIADYKGARGLSNTAYLNAAATIYNLIAGQWDDTCGGGVWWNTAHTYKNAITNELFLYVSADGYLRGGGQTYLDNANKVWDWLSASGMRNAQGLWNDGLTDTCVNNGQTTWTYNQGVIASGLAALYAATKNTTLLDQAEITLDATISLLTEDDILKESCDDALSGGSVCDADQQLFKGLWTKHVQYYLDMANDSTRTAKYSPFLGSQTSAVFHYGTDASNDVGSVWYAPDQGGSIFTPKTSTSGLEAHVAAAKYGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4C4</accession>
    <name>A0AA38N4C4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1207588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4C4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="348" mass="38131" checksum="B19532CAF148142C" modified="2024-01-24" version="1">MYSILTNSLSKWRFDLNTRTTGMLCGSSSETLARARELLYIATVRTAPGTGFQLKDPLGRPAACALIASEQLKNTVVDPTYGDRFVSWCQRAEFAFFDLGKGNNIARDSPKIKLGIFFWVCGILEPDRLDLASFVKNNGAHTDNTGGITKITDVHGSKIRALILAESKRPKETVATRSSTRVSPGKRPMREAPSKDSPKKRKLSAEDDTVGTTAGKQFSVPNHASGPPKALFPPSTSPRKSPSKQVLRELPTKSTTKKTRFTVVGQEDSDVEMSLPDTPSKRRLLGTSSDQVSMISPSRPRAPSPSPTRRSIRLNSAIESPSQTVVNIKTLYIDNPPERANMFATTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4D1</accession>
    <name>A0AA38N4D1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_522003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4D1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="740"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="928" mass="103139" checksum="0EE166239E4337F3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4X3</accession>
    <name>A0AA38N4X3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1048113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4X3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="61"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="631"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="844"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="592"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="652"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="873"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3737446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="893" mass="100890" checksum="E2F0B3005588F05A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5V3</accession>
    <name>A0AA38N5V3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1148795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5V3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="297" mass="33406" checksum="1ADFA7515852A9E2" modified="2024-01-24" version="1">MPLDLLILGAGWTSSFLLPVCRTRRISFAATTRSGIDNTIKFLFDQDSDDSEPFKVLPDAKTVLITFPITALGGSQRLVQLYKNTRTEKDLNPAFIQLGATSIWGEQGSRQHKDPALKVITPAENKWYDRHSLYNPNERSNAEDELLALSPVTPTTVLDLAGLYGEDRTMRRWVGKVAPTKEVLRNKGSIHMIHGLDVARAIVAVHNDFSRAVGQRWLLTDGRVYDWWDLASAWGSGPLDSTDSEDRGPQAVWVRELMRETGVRALPRSSEILGRALDSREFWETFNITPLKGRMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5Z0</accession>
    <name>A0AA38N5Z0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_987236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5Z0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041276925" evidence="1">
        <location>
            <begin position="19"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="384" mass="42076" checksum="4839007ECE326A7D" modified="2024-01-24" version="1">MLILLAVSWISLYLNDRAKVTKLSPKDCLALHNLNDLISCLDAFTVSPSFYDSVSYAAAQPTEEENTAWTSVVSSMLDVNANDCSSIKLPSVLEHFYVVTTFSDADSTRSFCILSETTTSINQNYTKGWGSMIVPASAKQISRRLHLSAPHPQADINTPQQAGAIFVLSGAHSLLVSGRFRSAYAMETDCIVPTQPRKGYFKTDPTHDINEPFSIANRAIRDWQNANDGCPSETCAYVQFHGKAAASCAADTMFISSGLGNSNSSLSWYRDPSLDIPARRLRDVARTVFPTWNVTIPPDDPDCALTATSNVFGRLINGVPESNVCMTEANTLTATGEFIHIEQAIVSRQSNVYDQWGEVFKRTFRTSCTEGTVEDSETGICKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J112</accession>
    <name>A0AA38J112_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1173308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000158">
        <property type="protein sequence ID" value="KAJ3709749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J112"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041331873" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22188" checksum="9742F772E7B35514" modified="2024-01-24" version="1">MLVVALLLMALSTFDVSLGLMHSIEAFIFYTGPGGSAARFTGLTDWVNILKTCNVVFGKVISDGILIYRCWTICNRSIVIINISNTLVDGISRNYCLSYLARRQNQCLYGIQTQNHPYKGPTVSLAARSVEERIANVIRIIIESGLCTPPLLSSHSSPLWWEVTLSIQLQMRELSQCKRTTCGTTDIPIAQIQLCNEEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1X7</accession>
    <name>A0AA38J1X7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1008820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000117">
        <property type="protein sequence ID" value="KAJ3711620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1X7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="127" mass="14221" checksum="85D199F367969A5F" modified="2024-01-24" version="1" fragment="single">GGFSLLNHLDLDDDDDLDLNMVPFPTPARATMDSQPDDLSLHPSNQPSLPAPSTSRSHQGISTQPIALDPKKPLFFPRSIALSTSSATSPPFYTHPTPEEIQKRWEENKLELTRGWKKRYREAGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J351</accession>
    <name>A0AA38J351_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DFJ43DRAFT_1212460</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ET3784</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000081">
        <property type="protein sequence ID" value="KAJ3715934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J351"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="181"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="719"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="984"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ3715934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1137" mass="124616" checksum="A4EA0DAB303EF4E5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4Q3</accession>
    <name>A0AA38J4Q3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_789407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4Q3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF11">
        <property type="entry name" value="SHIKIMATE O-HYDROXYCINNAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3717649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="500" mass="55840" checksum="4A981884FD6CCD9B" modified="2024-01-24" version="1">MKTNTVTFTHPSVNVLENRTLHCYRNASYSNVPTTIKVGPFDQLVAPFIPVAVVFIYEQSGSLEPIPVRRLQRALELLLDYYSHLTGRLNIATDGTYEITRIGTGAELLVAKCTDRLDSFSLDTPGRISLMDLPGASNALFGPFDASLEGICRDPLFTVQHTRFACGSVALGIRLRHNNCDGNGYFQLIRDLAELYRGLKSDYIPTLARPPHFLSYMSDLDMTSDEKQEALAFKPSLLVIDPLPEAIKAPSQPPPHVVGRILRFTGAELEALKVYATDPSTPNNWVSTFEAISALLYQSIYQARLRYFSEDPSAVSPPDFLTPFDFRGKRFPELPPAYFPNALLCLYTSLSHDMLSHAPLWQIAKHLHDLMRNKVPDAGHLKSTLRWIAAQPDKTRIRSGFRYGNGSIMVSQWVKFDMYAGTEFDDDEKPKLVSTPFTSISLVDGLAYTLPTEMQGKAGGDKQAIDVNLALSEPIWEILERDEQLKQFSTSWSPIGVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J572</accession>
    <name>A0AA38J572_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GH16 beta-1,3-glucan recognition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1044588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000138">
        <property type="protein sequence ID" value="KAJ3710508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J572"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="269"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3710508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="585" mass="64632" checksum="58DA67A0DBE6535C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J580</accession>
    <name>A0AA38J580_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1090603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J580"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="43"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3724178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="561" mass="61333" checksum="313961515EDEB062" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5N7</accession>
    <name>A0AA38J5N7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000176">
        <property type="protein sequence ID" value="KAJ3709490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5N7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3709490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38242" checksum="173ED2FFFF992657" modified="2024-01-24" version="1">MSPANSRANSPSDEEEKAELLLIQKRKEERARIDAERKAEEEAAEARLAEIHRKKEEKKREAEEKKKKEELERRKAEEEAKAAEAAKKAAEKAKKEEEKRKVEEESRLAEAAKRTAEENRKKLEMDRRMETAALIRAQIEKKKKEKLINSLVSETSTVVVGKKRKRVAVVVPSGDPEGGDPNPGDDNDYIESDTDDDENPEDPPASPPKQSRCSRCILKAFKCELVGPGSASCKGCRKAKVRCSLVPDDYPCRSKRMKVESPVASTNHQIIDDLRTNVRDLNTRINLQEEMLRYLILRVRKLKEANREEEEEEEESEEDRVRRTGDRKGKGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6F0</accession>
    <name>A0AA38J6F0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1228335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000107">
        <property type="protein sequence ID" value="KAJ3712555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6F0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="102"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3712555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="647" mass="72350" checksum="10B42B16504E2B6D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6I6</accession>
    <name>A0AA38J6I6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3724999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6I6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="318" mass="35042" checksum="663238D69371E7C1" modified="2024-01-24" version="1">MNMLAQSRAFRAEDRDFPILTKPLVNAFGTEIVKTDPKDSWFSQHVETVMMSDNTLDSNLELLPQADIHIKRLLQNKARKLLGESRNRMQLSQTVQVRYEPCSNQVPSYSSYSNFNNNNVVDSERKSGTPDDRFNDAHARFPVLQLAQLRINPPGLSHWESPSPPRTRHTTSLGAGKALPKQPPIDQDVPEGADGDKASDVPSPSLGSSPLVQAKSRSPKASPTRNMFSQVGTDRIGDRDLGRMVAQNVQEDVGFGRTSPALQLQLSAVQAPGCNDPIILNVQVHNTNSTVYNFNNAQGDVNHTTNNDGFSHASFNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6M3</accession>
    <name>A0AA38J6M3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1161806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000121">
        <property type="protein sequence ID" value="KAJ3711267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6M3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="60"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="284" mass="31022" checksum="0440F05CB15F0665" modified="2024-01-24" version="1">MSLPKCTLTWQQRRAVCQDTIARSATITTEYAAQGATLDSTFISEQLPPLPTLSGADAHSPKPLSIINSDSFTLARNLIEEDPDNATGRIAVLNLASDQRPGGGWDITLSKTQEEALCYSSTLFSTLSPSYYPWPNLGPGSIAGVFSPGVVIFKHDLDHDCVDLPTEERRVVSVLTVAAPCSPKLTEDQQSFAKKSDLADLRGKIRLVYRMAGWNNKDFLVLGAMGCGAYLCPPLLVATEMRDILLEPEFKGRFTKVVFAIYSAPGNGARNFEVFEKVFRGVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6V3</accession>
    <name>A0AA38J6V3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PQ loop repeat-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_983733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6V3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3725673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="243" mass="26911" checksum="70B56FB9A9C994D8" modified="2024-01-24" version="1" fragment="single">MPVNAVAENVFGTLGTVCWMVQLFPQIYKSYQEKNTVGLSDLMILSWALGGVFLGIYAVVQNLNIPLIMQPQIFGTLSVICWAQCQYYRRHWSPLKTIIVGISLWFVFGGFEAGMVYALRSPYDHGNKHAESAISFFGIMSTVVITGALVPQYYQIYKYKEVVGLSIPCMTIDLLGGVFSDLSLIFRPGSFNVLAGITYSLVVVTDGAVILAAVILNPRARQARRRTMVEMEQNTGQPTAMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7T3</accession>
    <name>A0AA38J7T3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_448922</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7T3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3731092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="529" mass="57228" checksum="962D70AAD516993D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8B7</accession>
    <name>A0AA38J8B7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_449280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8B7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09998">
        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="629" mass="68165" checksum="A4D4E23F81BD98FE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8E6</accession>
    <name>A0AA38J8E6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1102027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8E6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3715572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="62629" checksum="7396781131CEC260" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8E8</accession>
    <name>A0AA38J8E8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carnitine acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1006276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000073">
        <property type="protein sequence ID" value="KAJ3717584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8E8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="54"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3717584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="644" mass="72428" checksum="7AAEF7CB60F5E358" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8G4</accession>
    <name>A0AA38J8G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_425718</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8G4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040221">
        <property type="entry name" value="CDCA7/CDA7L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169">
        <property type="entry name" value="OS05G0300700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169:SF8">
        <property type="entry name" value="ZINC-FINGER DOMAIN OF MONOAMINE-OXIDASE A REPRESSOR R1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Zinc-finger" evidence="11">
        <location>
            <begin position="350"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc-finger" evidence="11">
        <location>
            <begin position="538"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="899"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111341" checksum="A3FEFD52D1C98323" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9H8</accession>
    <name>A0AA38J9H8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1161094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000097">
        <property type="protein sequence ID" value="KAJ3713747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9H8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="627" mass="66778" checksum="A7B26F5D6EADC71A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9S7</accession>
    <name>A0AA38J9S7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1215409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="73"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="638"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="681"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="724"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="767"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="810"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="853"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="896"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="939"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1111"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1154"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1197"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1238"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3714302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1417" mass="157004" checksum="873EC33C94601343" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9V7</accession>
    <name>A0AA38J9V7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1228288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000105">
        <property type="protein sequence ID" value="KAJ3712758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9V7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3712758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="39052" checksum="6B6D66BCD6BF6F3D" modified="2024-01-24" version="1">MGQYWKIRNIDYEETTGDLGKLGEFFWYGDDDVISLLITPVIPPHFKSKPVLSKTSVSEVKDDSTISPPTLLTLPVELLVVIAEELMDDYLNLICFSLTCVSMWELTHPVRYRVLESELRYKSWAGCRIILLGDYAQNLPKGILTAEEIGQLTMKNEDDKDSDEDEEDLDKKMDKTLGRRLYKADFRRVSLHLNISVLEDRRLWGRSSLYKELSKFDRRFRPWLSFDWNRFLPREAEGDSWMVRNFSKREFVAMSSSHHLAQVVFSLIGCSDDPSISMIDGDWLIEGPWAGNRIDITLASLHEQEHRDETDWKDITAEVKQRLEALAIAESRNFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9Y6</accession>
    <name>A0AA38J9Y6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1103984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9Y6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041384428" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3714563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="902" mass="96798" checksum="10EC5A5CC80ACA46" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB16</accession>
    <name>A0AA38JB16_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1138235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB16"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="197" mass="21465" checksum="414B7F5FD954890F" modified="2024-01-24" version="1">MLNPQVQVSNFLSAGQKRTTLLIPNSLRSSEISSFRLSYSLSIQIMRSVYVMAFVLGLLPLSYAVPVSGLVTPPHSPTPVIASFMGGSAAPASNEDTQSAINILEGYVKPLYPGREIQIFGSFYHFVDKDKTTVQFTLTDTSRDVIPSLRISCIYCRGVARRAQTAVDSVSGSSNFQSPALYEGKLTTDVNKWPSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBS0</accession>
    <name>A0AA38JBS0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_572833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBS0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="136" mass="14887" checksum="50D27157123B41D0" modified="2024-01-24" version="1">MSVTLEKNGATYFRTQNPFEKNFGFSRAVRKGPFIFVGGTTSFDPESGEMMHADSAYGQAKVIFETIIKSVEALGGKKSDILKLKLFTTTMECGMEVGKAFKEIFEEIHPAAILILGVTLASPEMKLEVEAEAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC28</accession>
    <name>A0AA38JC28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_994520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC28"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42072" checksum="5EA71339B2C02EB2" modified="2024-01-24" version="1" fragment="single">FPDEAERRAALIDILQEENIIPPDADLNPSAVCPYTTDEDLRTTALGCYGDFLYFLKVIRNEIHTGNAEPYMEAIHYWWAHVRDQIDKQKPEVRDRLNYPAILLVHPGSHFSVAVAAFTDVMNVETLATIPLHVHSTNVSEVLAGERFIYALRTTFQRLHDFYGAANNLPPRQIEYPFRNYIVQNEAKLAFEYIRQVPDKRVFHASLEDGTPLFIKFSRRYGEVTHHAAHDAGLAPRLLSVENVHGWYVVAMEDLSKDYVTLAEIPDDSYLSLLPEVHEAVCKLHALGHVHGDIRPVNILVKKPDVETVKPRIVFVDWDWSGESGKVCYPHSMNPEIQRSESAFAGAEIKPSHDLDMVSFCYNRDQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC38</accession>
    <name>A0AA38JC38_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1096945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC38"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041265344" evidence="3">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="60"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3719552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="39740" checksum="B66926DE84CFE443" modified="2024-01-24" version="1">MLYQALTAVFCILSAFSPLAAAQTASNASLLDPSLYKNVNVSRGLVYHYYYSPPSQVGRPTLLLLHGFPSTSYDWRHQVAFFQDEGYGLVVPDMLGYGGTAKPVDPHLYKSSLISRDMVDLLDAENVNEAIVIGHDWGSKIVGRLANYFPERFSAFAFFSLGYFPPAVLERSYAELNNITEQVFGYGIFGYWGFFSTEGADNIIESHLDSFFDVTFPADNIFWITDFAPLGALQAWLEANRSTAAGSYITPEERALQIDAMRDEGMTAALCWYEIMTSTIERDDDQGIPQENLTIKKPVFLGAALEDYVAVAATQIAAILQVSENTTTIQQYDSGHWVILEAKDQVNSDLLSWIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCQ3</accession>
    <name>A0AA38JCQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1094010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="282"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3722104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="431" mass="48114" checksum="8A8794714B8C664D" modified="2024-01-24" version="1">MPFRFTQEIMQGYHDFFRLLIPEPQNRIPITPSVVPYTLSWSIPFFFLAYLARRPETHLIRLLLLPTVIATTLASAFRYCWTIPALNVYNWGQGLAAEVVIAKALEYALTPEGMLRIGESQPNQPKGKAKAESNGDASIIDEDDPTPLAKSHSSSLIAAFGDSLNLAHEMRGAGWKFGVGTHIPKLIRPLERDQFLKVTLWSFIKYFLLLDLLESIIKLFPGVGTPAGGSMFYQNLPILQRYIVSTTIHILTGSALLSGFHMVYDLMAFIAVYSCNDSPSSWPPVMDNPWTADSMHVFWAKRWHQLLKRTFVVYGGIPGYWIAGNTGALLGTFIASGLYHEFAIYAMGRGFDPVVPAFFALQGPVLVLERGRGWVGRIWVYSIMFCLAQPMIDSWHKRGLGGGMVIPPFISPAKFVLPLLVRAFNATVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCV1</accession>
    <name>A0AA38JCV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Elongator complex protein 3</fullName>
            <ecNumber evidence="14">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1092303</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14 15">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="14"/>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCV1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 14" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="16">
        <location>
            <begin position="83"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3722780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="540" mass="60687" checksum="715629EEF2A8E0AE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCX3</accession>
    <name>A0AA38JCX3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1024365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCX3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="40903" checksum="E72B9E1DFB5B68BC" modified="2024-01-24" version="1">MHHSKISGIAILGAGIFVGEAYLPALATLGHTSPPLKAVYSRSEKSSTETAQNATRILGLPSSPDVYFDGDHPNNLDALLGRSDIAAVIIALPITLQPDIVLKCLSAGKHVLSEKPVAPDVARGLRLLRDAEPICQRHGLVWHVAENYETEPVYRAAGEVIKSGKIGNIIFFKVAVVNYIDKTSKWYKTPWRTVPDYQGGFLLDGGVHTIAALRTMLPQTFTHLSGFASLNKEYLPPHDTIHCVVQAGSHYHGIVEMTFASPTKSVPAAENIVITGSKGWLACNATSEGFKMVIRIAEQKDSEATEEKEEIMNFPRKGVETELEAFFDDIVKQQAGEHTSSIGDPKAALEDVAFIQAALTSKGNLMPLPSSFKLLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD05</accession>
    <name>A0AA38JD05_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1179346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD05"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29388" checksum="1ED9DC0345361849" modified="2024-01-24" version="1">MDDETFLLLLLSDSNLPTGSFVASSGFESYIKHGFGGDQNNRTIMFMRDSINAYARSALAFVSDTHRIVQDVHRDVEQGSEQKSDFDKYLQKIKEVDDLYDAMTLNDVTKRASKSQGVALLTLYSKGLTPPLAFTGVKNRKEIEIEVNSYMASLVAQYKSLVRAESAPGHLPICWGILTGALGLTLGESHLRSQYLHIFLHARSLLSASVRLNEIDLRTGIPSSTGTESDQPDGVDDKSRGPANTWPLGEILAARHDLQHSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD32</accession>
    <name>A0AA38JD32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_95235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD32"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="282" mass="32187" checksum="3AE6D8770B1BC985" modified="2024-01-24" version="1">MSLDEGSTSHPVFINPSYFQHIRRSNKWACTLCIDANKKRKPMSYREAIQHERNSSDHAFLVKAQLFQQPQQQQNTQPSAWDQSFNPWEAQGASVEAWFPPATEDATLMSKEQLRGKDHQYFADQVDDMVPFWIRGIEAAERGEVLKLEEFLNSLDNETWPPRGPNPWAHIDRHSTFGGRAAREPTTCNHDVAKWIVESVSSVSAESGRSTRRADGDALPTASHDIRSKSTSVRNPNPLVEIIARQNAADEKQKQRMYTFFELPTNEKVKKIDDLIRSLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDE8</accession>
    <name>A0AA38JDE8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1139791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDE8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041366638" evidence="2">
        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="337" mass="33112" checksum="63E53B68782BD3A4" modified="2024-01-24" version="1">MIKSNGLARLALSILLVMTLLTACNSMPIGMSKLSGSDEDSALTSSAEGGAPISSTSAINPTDPTATDGASPTTTTDSSSESTGSFSSTAADLSSPTSSASTSGDSSSATASANISSASSSPVAFSSLSADVSSATASAGVSSGAGTSFASASASSSSDTDSVSTTASSSSGSDTPSILGTSSGSASASASSFSSADTSSNSSSSTTGDVSSDSSSSSSASSSSSGFSSSASPAEQNHDGVPNLMHPLAKVGQSENKTISDHQRWPSAVAAATIDGAIFPETSKHPRVRAGRLSFKIGQKCKEMKEKGYWSNVGEGLKKSITILPLIFEAMVKTARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDL1</accession>
    <name>A0AA38JDL1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_71286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDL1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF732">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="526"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="556"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="598"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="638"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="744"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="855" mass="94991" checksum="F4C640B3E833C115" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDQ3</accession>
    <name>A0AA38JDQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_882187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="698"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="871"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="915"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="947"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3714310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1217" mass="134171" checksum="97E82C2193B5FD5F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFA1</accession>
    <name>A0AA38JFA1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1207162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFA1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="309" mass="33612" checksum="B1C5153FEBCA7EC3" modified="2024-01-24" version="1">MLPPRAYIFIGLNAARVLSVIAMLLVFSSSIEVMVTNIKAVNYYEAHKGDNNATMSAMNMDYIAGSTVPSQPAGIFWAIVSSLLIIFQTVTLILSECSWPISFFDHFFPVLSSGFGTELVLKSCPTMSTNLLSFQPSSSSLSAASICSLAKSKRSITSWRSESKAVLPTIGNPRPVFVNVSPNYTGNSEKTQLISEFGSFRSTDKSGYGFGRQGEKTAGLRGFILQRPEESLPRYVSPTPPAWPPTRTVALGRNNSTTSSFGTPEPVRASVRSASHYDDDERSTVAEEEDEEAIRHHSPPVFKSSCTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFC3</accession>
    <name>A0AA38JFC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1055573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFC3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="503" mass="56192" checksum="1D1048467582123C" modified="2024-01-24" version="1">MSIPNTTVYFSDFVPTGSIIELRDNDPSCGRPSQFVLEDICRISMYTSTSTRSGLNLEVWLPRNWTGQFLSTGNGGLSGCIQYEDMAYASALGIATVGANNGHNGTSGKAFLQNPDVVEDYVYRSAHTGVVVGKAITKEFYGKSHTKSYYLGCSTGGRQGLKSVQDFPEDFDGVIAGAPANDFSGLLSWSGRHFGILGPPGSPSFITEEQWTNLIHTDIIEQCDTVDGVADGVIEDPNLCDYKPERLICSSDTNDRPNCLSGEQAKAIRTIFSPLYNPEGELWFPRQHPGSEDAVTRAMMYSGKPFPYTADWFRYTLYNDPNLDVTKLNRSDWAYSQAVNPFNIDTWKGDLSRFKSRNGKLITWHGQSDGLISPANSERYYDHVSHTMNIPPSELDHFYRFFRISGLGHCRGGDGAWAIGQTLRNIEEIQLDKEFLDPDRNVLTSMIRWVEEGKAPDTLFGRKYVNDSMALGIQSSRRHCRYPLRNQYHGNGNSSLPESWTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFI4</accession>
    <name>A0AA38JFI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1007667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFI4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3714588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26000" checksum="0F7F480CFFCFC1F4" modified="2024-01-24" version="1">MPVGFLIVYSEPGELVTLEEFQDWYNNEHVPLRMKHLQSFLAGARYFSLDSQIPSWVALYDVDDTATFSHNSYVRLRANRSPREANLVKRLSILDRQTCELVMDSGASILTTSLASKNPSRGIITHGLGMHEEESREWLGKAVELLKNSQGWARTRLFKCIDNLKTGVSVPSGPEVQIVPVFFVVHEFTTSEIASDPTTATNILSISTITPLSELRKWGLYRAYPGIAQGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFM7</accession>
    <name>A0AA38JFM7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1040982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFM7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="265" mass="28867" checksum="74F86443FF6083CC" modified="2024-01-24" version="1">MSNTQPRPLQWLHRIDEKKLAVASSIGRILFATTTDELRTALKFDTYLRTYEGNLNQLHVPLSYHAFAERINSDPGITGGFVTIDILNETFTVPPTPVHRAIFSEFLRPLGSQGESALVNALGLSGVSAHKQRVYGKLLIEQVEKNLDKRPRKARKGNGKDKQTGKVNKQFLADSPTDVLSSSSQYASHSTITNTPTTAYLVGPSNPLDSTSGTYDPPSPTLSNLFAGPSHTNPDDYALFNADPATLPTSSNQDSNETPPMDTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFP9</accession>
    <name>A0AA38JFP9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1133309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFP9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3726538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="145" mass="16386" checksum="4648C9390B1B4E5F" modified="2024-01-24" version="1">MGRVRTKTTKRASRVLIEKYYPRLTLDFHTNKRIIDEVAVVPSKRLRNKISGFTTHLMKRIQKGPVPGISFKLQEEERERKDNYVPEVSALDTSVAGLEIDPDTKALLTALNFDSIPVNVVAPIVLAPERGPRRERRNVPGAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG28</accession>
    <name>A0AA38JG28_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HLH transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_345537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG28"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="167"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3731914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="270" mass="29232" checksum="FF8E4542D472812A" modified="2024-01-24" version="1">MQSPLTPPAPYADFQLSFDPQSSNLFPQPPQLPPSAELFSQSETNELFNFLDGFDDSIWDAEHDLLDQNSLVNLPESPRLLPHSPYLNLHSKTVPKPNAAPSSSRARRTTRNRPGRAAARSNSKSSSHTSSSTTPPAQSFNEPSSPILDRPSTPTQSRAKTLLSTPQKRLNHIMSEQKRRNAIRDGYAQLIALLAPSGNAPALGMPTRGRPKGSGSRGKAGKKTGSDGDGAKGKSGVLFRAVEYCRWLEEGREALQKEVARVEAAGRSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG32</accession>
    <name>A0AA38JG32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Diadenosine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1076434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG32"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="9">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 7">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="6">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="18677" checksum="3C256E41BEE71A7C" modified="2024-01-24" version="1">MTSLFFSSFEVTRQCFYRTSLSYAIVNLKPIVPGHVLVIPTRKVPRLSDLQEAELASLMGSVQRVGNVVERAYGADALTVACQDGKAAGQSVPHVHFHILPRKAIGDHFSNNDEIYPALEQSEDSLNADLRQTTNKPLKVDADEKRQPRTEEEMEEEAAWLKMFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG57</accession>
    <name>A0AA38JG57_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1064682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG57"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="211"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="817" mass="86342" checksum="20559924CB919EE1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGG7</accession>
    <name>A0AA38JGG7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1079393</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGG7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="695"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="640"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="792"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="912" mass="97910" checksum="54B837CB038166C0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGL4</accession>
    <name>A0AA38JGL4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1037757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGL4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="214" mass="24944" checksum="4A9CED15EC019805" modified="2024-01-24" version="1">MYKIKYNLAQLQFQMSTKKLLESGPIENVTEGPSRTVRTRRRLSPCYTMLGPLLNGDLMPPEEEKVDGNTWGLYFARGASISERKRFPSYLRLRSHSRFIDVEDGFGFDTFGDHIYKIKVIVDDRRYFVAGTYDQSSRECNMALQFYGCSEKLKGDLVIFSLSKYQPERFLETFPRFKNAEEKQEVICRILTSFCKTVKAHIEKKAELHHIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH79</accession>
    <name>A0AA38JH79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_483941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH79"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="330"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3729142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="554" mass="61023" checksum="28E871DDCB65C9F8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHH6</accession>
    <name>A0AA38JHH6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fruit-body specific protein a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_659221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHH6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041241265" description="Fruit-body specific protein a" evidence="1">
        <location>
            <begin position="19"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="53316" checksum="5756B437B233AF20" modified="2024-01-24" version="1">MLSLARLLTFASVAVSLAECSGLVAPAYQGVPATVNDPPDFNGTSTDSSSIASTALQVDQKAGATGDALPDQPVPDTTVTAVDGNLVNATIPNPSRRGLAEDASESSLMRRNNSNYELVFWGTGTGSNDRDAAIEGTAYLTYTVVSNATYDIDDCLAFCDSVDGCVFANLYYEFFNPLLDFVFSQKSNLKCALYADVHSAAEKTNFGGQALYPSPGPLNFIQQSSGWAAKSLVDPTTPPGYTQTFGPTNGANNAPGYMGFAFIDKYDVQACADLCDTRGADPVGGVCEYFNIWRATVNGIPTTYTCSMYFIPSDNSTAVNFGQGDLLVTESRGYKRNSLIIDGGFEGYTCGSSSSAESPFCFTPGYSAWQGTSSPNGNLDASIFNYQPYAHTGNAVALLGSAYGTDNLPGTLAPTVPLVTEAGQSYTLQFYHSSFYSGEQAEAEATLEIIWNGQSVDTIHPGFSQWTVHQYTVTAQGNDLLQFKGGASPAYVFIDDVSLFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHR5</accession>
    <name>A0AA38JHR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_710986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHR5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="485" mass="53723" checksum="484C3A4D595C317D" modified="2024-01-24" version="1">MMTADRARPPVDLGAVSVNENSAPLYPPGLPHPPSRINGQTEAANQPHMVYSSYLPEIIYQTPKTPPLNAGPNQSPIPQPLLEIIREHERALNLVQPYGYGDLLARQALEISTSPAVPVLDARNDPQMGSFERVTNWNRNLPDDRHGFEDAHDTPAGHDPTNEAVRIPEEWRNPIKQTIRIPVLHGTRPGHNLTGGVRPVIETVEIPVLHDFHVRTRRNNEEEEDVYDFRSVSDYALADRVDGDNQNFANNLPRVNQQPVAVQSHHHPNGEPAVKTSHLGPSNMHYAPLRTQQYHPGPSDTNRAQLPTQQLAPGPDDMDRTRLHSEQSAAPDDERLHTPGQPLMRQVGPALDEGESGTYATAISHEQSNEQGRVLTRLPTPAQASDGHEDRSAANRPKDPDAQAREVMRQPESPHSFAQSTPTPKAYLRPDVAQASYPINKSAALHEASQPIDHNYYVRPPLFNPERVSSPNFDASSAKENVSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHW2</accession>
    <name>A0AA38JHW2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1189691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHW2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="291" mass="31543" checksum="6F8156AE1E1130FC" modified="2024-01-24" version="1">MTVSALPFDQPRDAALPSPLYPKFPLADGERGGHLDPRRDPAAPICHILSEDDLKKRYEQLVKEAKEEHGSGGYHLKTYDKDLPGKATTICVNGPAQVTYDSGTANKKLYCNEVVADAKGELTGTNGTVALMVLQGVQTTAQLTISSAASMGLSNMYQTQVAFPGVADLFDFFTTSVSITNTQTQSFTTTYTDQTTLSLTMSSVEGKTCHAKEVVEQCTIPGTGRVELIVKGDALFEYESPTGEKDDKKAGKHYKWAVAIDNLPPQARTGYIEFRVGLEVTTRGKFKGVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHY9</accession>
    <name>A0AA38JHY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_238732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHY9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="5">
        <location>
            <begin position="121"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22893" checksum="E7A6739C0D5532B2" modified="2024-01-24" version="1">MSVDLSKLDQHLSTRSYIEGYTPSQADVHVFKALSSAPNTSFVNVTRWYKHIASYAPEHASLSGSSTAGEAFLGSAAAEEDDEIDLFGEDEDEDAEAERIKAERVAAYNAKKANKPKTIAKSVVTLEVKPWDDETDMEALEKSVRSIEKDGLVWGSSKLVPIGYGIRKLQITLVIEDEKISTDELQEEIAEFEDYVQSTDIAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIJ2</accession>
    <name>A0AA38JIJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1052631</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="13">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="256"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="567"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="15">
        <location>
            <begin position="679"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3736526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="824" mass="91824" checksum="634D62D1227086F5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIL7</accession>
    <name>A0AA38JIL7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_998121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIL7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041315655" description="FAD/NAD(P)-binding domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56284" checksum="7892009004AF8B0E" modified="2024-01-24" version="1">MTRNPILLAYQFLQYLLARLLSPSPPSPNAKLNRPRIAIIGAGLTGVSSAAHCVGHGFDVVIFEAGDRSHLGGIWARVNSTSGLQIHSLMYRFFPNIEWKSGYPNRREILDNIDNIWHQYSLEEKTKFNVTVEKVWQDGAGRWTVNDEQYGKFDGIIAAIGTCGEPKVPHIPGQEKFQGNIYHSSELDGKDAKGKKVAIIGGGASAVEALEFTSTAQAEKTFVLSRSDKWIIPRNALVDTVLAMNIFGQEILLSWIPEKLLRIFFYRDLADLAPPSNKGVFTETPMVNSDVLDKIREGSASWLRGDIVGFVENGIRFTQRAQGVPPGGPGKEVTVECDIAIMATGFTRPKLSFLPDDCFAEPYAPPNWYLQTFPPGYMSVCANNCTYVNAIGTVGNYHIGIYTRILLMFLVDPLTRPREGLMKAWIDMTRLFKKRSPTPAFDFFTYTELLWWYFFCVAINPFRWKWALFVFFGIGKSLPMRFVKEEDALREKLDRYESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIV1</accession>
    <name>A0AA38JIV1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1040145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIV1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="134" mass="16079" checksum="07497F7EDE5491F6" modified="2024-01-24" version="1">MPARRPTHKLRALYASRRARATSLADGPGYLYAFVDCGHYWKLGMTSNFERRKAQWDNECPCAHRRWLSPIRVTRRRRAESLGHLQLEIKCLDRPKRYCVHCRRTHIEIFVFRGHWNRTWRIVIRPLLLQVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJC3</accession>
    <name>A0AA38JJC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_416944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJC3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="339" mass="37724" checksum="48F0FF270BDE3991" modified="2024-01-24" version="1">MSTTKLILVIGATGIQGRPCVSALLAPQDDGTPSPYSVRVLTRDPTSKQAQGLASLGAELFKGSFDDLETVVLAFEGCYGVFVNTDTFSVGQQKEIYLAIKMFEQAHRVPQMRHFIWSGLDYGSKFGNFDPKYLTVHLDGKGIVSDFLRSQQSSPSGDSLTWSIITTGPYIENLGGVLLGPLAERENGSVVFALPVGDGHVPSISVEDIGWWVRYTFDHRSETSGQELKIATEMMTIDQLVETFTRVTGIPAIRKRMSVEEYLDRYPQTAQSIVKGEKGPSIKETFAGMFRVWGDDLLTRDMEWIRRVHPTGYTLESWIKEKGYDGTLAPDLRFFISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJG4</accession>
    <name>A0AA38JJG4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1068562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1529" mass="168510" checksum="765EBB03BEF8E7FF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJM8</accession>
    <name>A0AA38JJM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_184559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJM8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="390"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="641"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="493"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="944" mass="105618" checksum="C65A01137146F2F6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKI1</accession>
    <name>A0AA38JKI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1045436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKI1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045564">
        <property type="entry name" value="DUF5910"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19287">
        <property type="entry name" value="DUF5910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041274674" description="HNH nuclease domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24966" checksum="593BA423F302406B" modified="2024-01-24" version="1">MITFSSIAFRLTLIITVMVEVNALPTAPSTGAPVSSFRARGSLDSDRIVLGYLWVSNKEALALNQAHEFVLSTNANGSSNDHFLPTIYSRSENRNFGQKGLWKCTVTINDKIVEKLAKDGDMLFMPKHLENPSEAARLKYVNDKRRDLEKTLLFYYTDANESYHDAMNFPIGRLKSDPEKPQVSCVDHTEAKASALVRWDKWAMTDLRFALVPPDDMESFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLD1</accession>
    <name>A0AA38JLD1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1073747</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLD1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="242"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3732400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="346" mass="38927" checksum="2912AC0EE6F0AE8C" modified="2024-01-24" version="1">MNEVEDEKKPFSVNAQEDDLLPDPDETLMLNQGHGKVWMVKIPKFLLERWAAVNAEDVHLASLRIYTDPGPGQKTRIVLFLPQQNDPTIPPNPSWPMFGPNALQSLSDAEPDCYELDMVNDNVENHIVVAERPKDASFGLSSNPSAPPNPRARTTILTGRIKHDCSLRPAFSARYRKQMRERHKKYNTPQRQIQMIENAGVAGGRGGINRLSSGVGMGAGGAFRDLVATNKKPAKGTFERMARMPRNQLFDALFALFRDTPRWSIKILREKTQQPEAYLKEVLSEIAYLHRSGEHNGLWEVKDTFKTDGIKGENIAGPSILGDDVKMEDTNNFEDDDEDEDMEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNA2</accession>
    <name>A0AA38JNA2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1151429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNA2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041244485" evidence="3">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="276" mass="29063" checksum="2411152F1E07C119" modified="2024-01-24" version="1">MFTLTAVITVLSVIPSIFAQTVWLAGDSTMAEGGDGAGTNTDGWGQYLSQYLNLPVTNKAVAGTSARSFTSLGLFASLIDDVESGDYVGERKSCDPRTPFGIISATVIEFGHNDGSAGAIDNGDEDAVGDAYNLTATVTEADGSTEVIHTFNFYITNAALSLTAKGAIPIISSQTPDNIWDGNVLAAPSRFVPYAQEVAGNNSLVYIDHYDYVAQAYEALGETTVDTFYPVDHLHTSPTGANVVAEAFVRGLLCSESPLKNFVNSAGEAVPSECFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSU4</accession>
    <name>A0AA38JSU4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_997237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSU4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="68" mass="8026" checksum="F5A3CB038E60BED7" modified="2024-01-24" version="1">MNIIENVWNFVETHIRRRSPLPNSVDQLWVALQEEWSRIPIEYINKLYDSLPRRVSDIIAANGGATRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT00</accession>
    <name>A0AA38JT00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1128822</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT00"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 13" id="KW-0288">FMN</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="14">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3737764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="491" mass="53518" checksum="BABA9F690A02DC75" modified="2024-01-24" version="1">MFKASVRGLPRPLRIKVQQSRRFATVTDTPVRRYGGLKDQDRIFTNAYCKHDHGLKGAKSRGDWHRTKDILNKGDAWIIQTIKDSGLRGRGGAGFPSGLKWSFMNKPNWQDDKRPRYLVVNADEGEPGTCKDREIMRGDPHKLVEGCLVAGRGMNANAAYIYIRGEFYQEASHVQQAINEAYADGLLGPNACGTGYAFDVYLHRGAGAYICGEETALIESLEGKQGKPRLKPPFPADVGLFGCPTTVANVETVAVAPTICRRGGAWFASFGRERNQGTKLFCISGHVNNPSVVEEEMSIPLRELIDKHCGGVIGGWDNLLGIIPGGCSVPVLNQQKSGEVLMDYDSLKDAGSGLGTGAVIVMDKSTDIVSAIARFSQFYKHESCGQCTPCREGTTWMMNMMNRMVTGRAHVREIDMLLELTKQVEGRTICALGDAAAWPIQGLMKNFRPEVEARIAAFRASEGAVGFGGHLGSQIDPSLALPDNLGLRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT66</accession>
    <name>A0AA38JT66_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1056786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT66"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38384" checksum="E2D3043CE4407BBD" modified="2024-01-24" version="1">MATAFKYVRQKLGLILFHDNRSLTCGVVWSNILLTFHFKRLSLVSFQMGKFTESSALVPFPDLPIELIREILDFAAFSSSKTSLSLTLVSSTFRIWTVPILYSTVVLRTASDVKSFLHALSSPYAFDSPLVLPVPLSQHVKHLAIFALGPLQHIEKIISRCSNVQSLACGFSLASYASINLKLPTATVVEIPSQTQIIERHLLGLSCRDSIPFSLLSQDTTHLHAQISSLQVLLSLLQMHKQLPILSHLALRIPSTLLATRQSASLFFKSLEEYNGNISTILVLITDRSEASFNEWEVAKSMSDGKVVIERASASAVSQWENTSIIGKGSLWASADAEVERRIRNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTP3</accession>
    <name>A0AA38JTP3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">DFJ43DRAFT_1049127</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">ET3784</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTP3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 22" id="KW-0408">Iron</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="24">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="25">
        <location>
            <begin position="108"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAJ3737083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="484" mass="53651" checksum="43889DB1F487C034" modified="2024-01-24" version="1">MSWSLQEVSKHNNAKSCWVIINKKVYDVTDFLQEHPGGSSIILKYAGRDATGAYEPIHPSDALEKNLSPSQHLGPVDNDAVGSLEKAEASKKKTKDELRVEQFMKKRPPLNRIINLADMEDVAKQVLSYRAWAYYCSASDDEISLQENARAFQRFFFRARVMRPVSKCDPSTKILGFETSLPIFVSGSALAKLGHPLGEVNITKGCAPSKIIQMVSSNASLSYAEIAAARSPSQTLFFQLYKHKNDAIALNRIREIEQLGYKAIFLTVDAVVPSNRERDVRSPWVLDDQETGIKVYNDGEGAADTDPGLGVAGALIVNDDRDMTWEKTIPWLRSVTKLPIVIKGIQCVEDAILAAEAKVDGILLSNHGGRQLEYSLPPLEVLYRLQTQQPHIFDKVEVYIDGGVRRGTDVVKAVCLGAKAVGLGRPFLYAQSAYGEVGVRKIISILEREIVTTMRLMGVAKIDELTPDLVERVDWQPVARLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVE0</accession>
    <name>A0AA38JVE0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1149926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVE0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="170" mass="18971" checksum="C33C11C68DA90EBB" modified="2024-01-24" version="1">MRFNPAYLFVLGSIPATLCLTLNVRSDMRSYVGLVETPETRAFHQDHGMHFLAARADHNAVHVQFMPGVEGNEKPPPKVLRLITKLFETWTGVPLITPEFVNQLSEVPPNGYLIFHFWGSSLQRCSVSFNGCSVIIGEVTAEREQWITIHEGAEILHSTTTKSLAVEPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVI9</accession>
    <name>A0AA38JVI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urb2/Npa2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1149418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1350" mass="152283" checksum="3FB2260B73FA2B1A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JW23</accession>
    <name>A0AA38JW23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 3'-terminal-phosphate cyclase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_260663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JW23"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, RPTC, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="9">
        <location>
            <begin position="189"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="6">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005378-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="375" mass="39571" checksum="41A6E1164FC7D518" modified="2024-01-24" version="1">MNISINGSVLEGGGQILRNSVTLSALSGKAIHIHQIRNGRKPPGLKNQHRTGLQLAAVIASAKLTGATNGSTEIEFTPGALKTPGDFVADSVTAGSTTLLLQIALPLLLFTSQPSKTPSRLTLKGGTNATHAPQIDYTENVFLPFVRRFFGITTELQVKRRGYYPKGGGEVLFSVTPLSQCLKSFSLLKRGNVRCIKGIAHLAKLPGHIGPSMVDGAQKLLSARLAGDSGSSIPIEIQSRRERNDNTVGAGSGVVLWAELEGGGIIGGSAVGTKGIDASLLGEKAAQDLLRGLDAGGCVDEWLEDQIIIFMALAEGDSAILCGKGELQLHTRTAIWVAEQLTEARFNTEQLESGHTIIRCKGIGYRPSASSDMPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JX10</accession>
    <name>A0AA38JX10_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_399545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JX10"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="264" mass="29131" checksum="FA06D299A4A96AB7" modified="2024-01-24" version="1">MEAPTRQSPIQEESFSLPSSRLRPRRTIQAEDENSLRPLSGPAASLAPSTFSRISHYMPRLFRTVMKDELCYTTMITICCAILAVIAVVGVTSEGLLWFMDWACLYWAFTSILATHSLGRAVSRHERESMLQAAALHTRRWENERDRTTSADRNFPSSNRIRRTANAASNADSENPFDDARALTSSYNDSMTPSPSDTPSSPQSLSLTSSPPLYPSPTLQFPTSGRTTPLVPLDTTAMMHGTGFVIDRNSSNSGSSYRLTRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JY75</accession>
    <name>A0AA38JY75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1128725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JY75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="236"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3737585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="559" mass="62649" checksum="5C5F55561EB30422" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQC1</accession>
    <name>A0AA38MQC1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000141">
        <property type="protein sequence ID" value="KAJ3710343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQC1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="258" mass="29066" checksum="8F00B82214D641DB" modified="2024-01-24" version="1">MDGAVFNPFSEEVEEAEEMVKEIEQERGRGGTEIHHLQNLRLEMVGCEDSQETDNEASHMSACLGGKKQVVPVELIPKTHVGQRAQRQQHKTQKTHEKATAEKKKSSSKTWIVLRSCASTASDQPHYRSSSAYCRNYSTRTAQRSEGIVNSSTKGPLDLHAPNRLLHSLMHRPKKMFMRQYDVDESELWSSGGNGNDDKYGDHNEDGKGIDKGDDVNESKVDDGDPDSEIERLEEEIKLCKEKKKARKTSIRDEIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSS4</accession>
    <name>A0AA38MSS4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1040643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSS4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF83">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="390" mass="43667" checksum="74244C21AE4EEE34" modified="2024-01-24" version="1">MPLLSHVSSKPEERSRAKLRNHRSLPPLVPYTILLQEDIPPVEALGGCGLLIASGEADMVMRGDQGGSVRIPASWCGLFELKPTFGLVPYTGIAPLEPTIDHTGPMTRSCLDNAISLNSIAGRDNLDDRCAGAPLPSELPDYLRTLFAMKDADMPLKGFKIGMVKEGFEICKNGPLNDLRVGVKVQEAAEKWRELGAVVEDVSIPMHDLGATLWVCISRMGSLPVLWGEMGGRSGYQMTELTKKMYNIRTEEGCDNTPWSPKNMILNGTYLWDKHVRPSQLSLLIRENSTERLSTIRRLRATYNEVLSRYNVLVMPTIRYLPTTHAPPEASVLAESWADLQHISLQRYRASFIVDDKNFRFPVGLQITGRHMDEMSIYKAAFAWVDWKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTT3</accession>
    <name>A0AA38MTT3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1131929</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="248"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="739"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1513"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1440"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1519"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3732239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1969" mass="215773" checksum="07F51A60BD504B85" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUK1</accession>
    <name>A0AA38MUK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1223474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUK1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="304" mass="33713" checksum="04C204BCFAC14AE7" modified="2024-01-24" version="1">MKFSTFSFIIAGAGLLQTNASPLRVVFVSHETSVGPQAGSNNETVAQIQVHPLKPHPLQTLNKEQGSSRHGCAGSRALSVSNALRQALGLPLIETDVVHPHREGGKIEGAVRFLPFAFGGPVLEHDDDDNENVGARVYHKHHSHHQDEELNTEEEGGGGEGRVHHSHHHHHHHDQPTSMEEGKGEEGPIHHHHHHMHHKFHGKGARIHHRSSFMRRLHFAIMTLGPWEGRTVAFVLGCGLGVLLRMLWVLTVVTYRTIRGDSSTQQSLYVAIPNQYDAEEVFVPPPVYVVDEKIPDQEESSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUL3</accession>
    <name>A0AA38MUL3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1153281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUL3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="183" mass="20790" checksum="9B8B59F1EB2C6410" modified="2024-01-24" version="1">MADPIKKIPLLFTPTSLRRKMLKSEHRRGRQDSSGINRQEKLKLAEHHQKVAEARTKKDQTNAAKRLAAEQEIDVIIPILTLTELESCLLKGVDRYLTINDLTRHLKWHKKNGIAGAVTVLGGKRDEKIQLLRAAIERYLEARTSGDFVDAEVEGEEDHPEVTVEDLGGNSDGYDSEEEYYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUR3</accession>
    <name>A0AA38MUR3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1161598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000113">
        <property type="protein sequence ID" value="KAJ3711882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUR3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="191" mass="20876" checksum="92C9638A263576A7" modified="2024-01-24" version="1">MFGLMNPTLGVPVRSPEPPKLDYNLPTQVRESLFVETAMVLFRATDKVAAAAAAAGRESLDLNDNISHAARLLVDFVFRSTWRELHILPKIRPSTNEIYGIRTPKITIRPDGSLAGWTPSKKLSFMLDTMKGNGAQSPCSGCEVSVNPVLGHEGSYGIKIRGGVGLGKVAEMDSETLKKLKQLVPFEWPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUV5</accession>
    <name>A0AA38MUV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1103523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUV5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041336382" evidence="2">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3714596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="510" mass="50685" checksum="6EA4E8C0A4DDD3A8" modified="2024-01-24" version="1">MPSFTKSLPVALLVGASALASPIAPQPIDGKDLCIAPCTLINGAQLCSVPYNNINLEDPATYEDFRPSQIPSTDFDAYLRTCQSALDGVPVGDGKKHCSPDNNICVMLARPYGSASSNSTSNFTSSSNSSSTSDVQGTVLITTTTSRNNTVPNPDAMENSRFGVQAKGPVPTLAPGDNENGLVDFAQTNGLARISESGSESASNTVSPSSSHFSNSLSPSGSIPTVTSSVISSAASSIATRLANAFGVASSAGNLGSDNLFGTLNRFADASSNANPGSVASSGLSVLSADGSSVNGPSNRLGVSNSANGQSGSAEPIALTNDLARLQATDSTERPSPPSPPSAGVVPLNGEAPIPTSGQIVSGPSGSVTVPGSVNRNSTRPSGRVGIIESAQPSTPAGSSSVDVAGSANGQSETGSSNGLEVSESANPSASTGSYGLFGVSGSAQQQSGSGFPSNRVKASESADSGASNSLEVSSTGSNANQTSVHDFEASVEGDCACEQGAREGAAVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWV0</accession>
    <name>A0AA38MWV0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase activating protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_670080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1845"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="1935"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1760"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2132"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1125"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1760"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2132"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2162"/>
            <end position="2171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3722154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2187" mass="242290" checksum="716CB6C3EE42518A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX61</accession>
    <name>A0AA38MX61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1150489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX61"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="219"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="500"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="794"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="902"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="818"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3736169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="931" mass="98702" checksum="6451039D951408FA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY22</accession>
    <name>A0AA38MY22_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1149613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY22"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="56"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="150" mass="16121" checksum="C1D4ED326EB52F6C" modified="2024-01-24" version="1">MQSILRRTLASSNPLLRCRASLSPRAISKPFGFRTIVTKRYTAEHECVAFDDTTGLGVISITDHAQSSLGDVVFVELPQVGTEVSQHDQIGAVESVKAASDIYAPVSGKVEEINETLADQPGLLNKSPEEAGWLCKIKLSDPSEASIPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYF0</accession>
    <name>A0AA38MYF0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha/beta knot methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_264011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYF0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3737444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="393" mass="43139" checksum="FE4974837ACFB276" modified="2024-01-24" version="1">MAQLSSPIPTVPRRRRHSGTTSDSDDLRSALQSARKENGNSRIDPPPRPKSTPGERPALRRRQRSPSGSETEEYEDVEMTVEVEEEEENLNINQNTLLTTTTMDRPTKPLPTKSLNPRAQAFNITVNPNLPNLSNPHLLPATAHVPRGPAVNGAGIASSSAPRRLFVVLEQACLEAYRISSSSKTNGKKFKEGEVKYTLLNCDDHQGILAKTGRDIADARPDITHQCLLTLLDSPLNKSGLLQVYIHTAKGVLIEVNPHVRIPRTFKRFSGLMVQLLHKLSIRGVQGSEKLLKVVKNPVVDHFPPDTYKITLSGDAPLQKLSTYLPTLFDPPKGSDRKPAKNLAVFVGAMARGKDDFADAYVDEKIGVSQYALSASVACGKFCCALEDLWDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYF8</accession>
    <name>A0AA38MYF8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">DFJ43DRAFT_1089866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYF8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3724930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="180" mass="19690" checksum="E03EE427FF4BAEC6" modified="2024-01-24" version="1">MVSPETPGPAPDSPRSSQSPVPEGHQGNLELELLGLANALYNLGTTVINDSTKERDKPGGGKQVGLRVNQVVQHLSTVDNMALDTRTMIPMQILTDIDNARNPMQLTRERLERTATENQFMNGKIAAIASYRDYLNEALCQNFPELEELLHPSPSDAPMAETPVQAAHDIELTETIPNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYG5</accession>
    <name>A0AA38MYG5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1044868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYG5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="323" mass="35681" checksum="57366BA5C4A173E2" modified="2024-01-24" version="1">MAAMHNVDASKKAAARNRNFQSIPPSSVPPQSHVKDPFYGYEYIARLCARFITHLFACPEYPPTSTQSQAKLPHFIAYAFHRTKLHESVTFAALALLQRLKARFPTARGSSGHRLFISAFMIASKVICDDTYSNKSWSIVAQGMFTLREINQMEREMCNYLDWELTVDNPILANFTTMVKEDFRTSQGPYPTYPLKLVSKRAAKAAATTSTSTTPIPEHNSTTSPIPIGHPTSPTKPPQSPQTLAPVRKSSPSFDMSPDTPSSSHSDTTSPATTSSPQTPIGDEDFSAKIRENDYPMGFSIIEKHMGAALKSKTFAFAIPAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYK9</accession>
    <name>A0AA38MYK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1162996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYK9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="442" mass="52059" checksum="70A58659724388CC" modified="2024-01-24" version="1" fragment="single">GYDIACGMVDKIARSPLRQLAKDERLQMLIGLLHGYAHNRLCQLTFLMLYIYGAGIEDLEVCERFFSHSNALASVTRYMSKFRRRQTISSYAYHRDNFETYANLSKFIHSNYRQALRIISRSQETARTLRELGLLDAGKVIGFIDEERSYLESRNSVPEPDVLASSYYRALVKLSDCREKPRRARRTFKLYEMGESCMEGEESLYLSERQMVNELELEAKLLVDVQCLEERLGIRVDQRWCKGSEDWRKAEELVAMSIYQKSLDKLEGLIVARIFELSRMNISGTGYKMRQHIGHAMQKRSTTIRSALEKYNEAAAKLTPPRKLLHWDDVMNYTYLSEFDFLRDTRSDVCDKTWAKPAVREAMSELFKLIRAEEEIHRLNMEIKRLITYMKEEEEYVSLVATSVQETNPSLAYQIRRYRDERRRYNVTHRRRLDSIRKLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYN9</accession>
    <name>A0AA38MYN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1002291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYN9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="24"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3726380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="549" mass="59921" checksum="7DF9492F1058F242" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYT9</accession>
    <name>A0AA38MYT9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1120733</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYT9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="213"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="624" mass="68035" checksum="54FFB19F05553681" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYZ6</accession>
    <name>A0AA38MYZ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_999564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYZ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="174" mass="19630" checksum="40E0D88E08696A03" modified="2024-01-24" version="1">MSQDFDLESLVNLEQSFYDAGHSDGFAHGQIHGLIEGRALGREKGFEMWEELGFYEGFALMWQAVYASQGKEDDRALNHIKHLLELISRFPRINPSSSDSSSDLDIPKLFRQIRSRYKALCSSLGVRPSLRASSDTQSKEQSMKDDFDDTANSKPEKSVWNIERGESGSEGLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ03</accession>
    <name>A0AA38MZ03_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1224900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ03"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="477" mass="53158" checksum="026E5E324247658A" modified="2024-01-24" version="1">MSSPCVPCSPSSFQPSSAKLQTKTTLLANTRTVNTTEASPLLNTGEFVGSKRARTTSTSSVDTIRISSGKKKTTSSKKRARASEPSLSRYDHKLLEDSRRTQQRKSSSCSTDTVRVLEISAVAFPTSSDIPEPSSSLGTENDSGLSKKKDERKITPPKLNPGKTAPSVAVTSVRHAPPPPIISSLVRSRVSSIKRPESRPTSPAVAPHHYPSTGFEPLPKHLQEWQPSSTHYMLSDDEGSAYDDRASSPVPAWKDKWDKVHPGMSDLDISVCFHKKQPFFDVWDLPDDIYIAVPARLHLTVKNPRQWKELPSEPDLRYIDIRCNTFDYRPLSEYYPPEYSVSYTGTSSTEYADPAIVPADLSRGIIVNKRWNKTFPGNKMLFRESLITNFGRLPDDSVDTHSEDDDDFISMRGWFFKFMIPIPSWVLRHGNTRAFTIEASVWVGGLDDGGLLRGDTELVISHLRSEREMVKGVGQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ99</accession>
    <name>A0AA38MZ99_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1083633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ99"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1155"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1174" mass="129556" checksum="F7AA916DB74C6059" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZC1</accession>
    <name>A0AA38MZC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1156292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZC1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="104"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="358"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3729950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="498" mass="54594" checksum="56586A2D3D88B9C7" modified="2024-01-24" version="1">MEAQIKELLPFLRDKNPQVRQIALANLLPQTPQDAPNRNIFFDSQSSGLKKQEEPPVVRDLKLLCRDQLAIAHDAFKALVNLSDSPLLVASLSEPSFLNFLVSYIINPQSTLADLASMLLSNLTASANACSTVVSMKVKIIVSPKLLNGFFATESRSGTCPAPVPYPEGEVQEVLALPHLIDAFVQGANVEDIDDLAKRPRKGSLHFLASVLANLTSSLAGREFFSTPGPSNPLQPESDLEYPLSKIVSFTEHRNTIRRGGVASSIKNIAFNARAHRALLTSSTILVSVPSQSSSNSKFSKTSAPGIDALPYLLLPLAGPEELDLDVQEKLPEALQFLPPDKTREPDEVIRLIFVEVLLLLCHTRWGRDYLRGAGVYEIVRAAHEVETVDKISSHIERLVQLIKGEEPHLSEVLNEEEEYDALPRDDELPPETRLIQGLGKFGNMQISADGTSGTTNSAIDKIQGTKDEEEEEEEEELAIEPLGADSDSDDDDKIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZD9</accession>
    <name>A0AA38MZD9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_361868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZD9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3731775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="424" mass="48392" checksum="76F05F9386C99997" modified="2024-01-24" version="1">MGAVCCRPTPVDFDGDVSLFHFVLLRCVGKGAFGKVRVVQHKQTRDLYALKYINKTKCVKMKAVANVIQERRLLEEVDHPFIVNLRYAFQDDENCFFVLDLMLGGDLRFHLERLGSLQEDVVKFYIAQLSSAVEFLHQIGIMHRDIKPDNILLDERGNAHLTDFNIAVHFSERKLTGVAGSMAYMAPEILTKRGYTCHIDWWSLGVCAYELIFGRRPFRGRTNSALTTSISKDPLKWPEDAEKKCSRPGMLVIKGFLDRDPTRRLGCKPNGEGFQELQRSAWLQTIDWDTLESKEQTPPFIPDSKKANFDASHELEELLLEDNPLKAKQRKANRDNLSAEMRQMEEQFTSYDFKKMQRRSYYPHNQQLISTATGTSSGLASSRPATPATDLRPDNEIAIVNGSMELQGTDAGEMTKEVIEKEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZL8</accession>
    <name>A0AA38MZL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1000404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZL8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3730054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="181" mass="19955" checksum="539FFB469DF44E02" modified="2024-01-24" version="1">MPEPTTEKPLPPGMVLGPDGKPCKVCTSFRHWKPALATREQARSKTVATGAATTVAASPTSAFLQNKRANCPPDSEELGRATWTFLHTTAAYYPERPTPTQRANMLTLLRSLPLLYPCSHCAEDFGEDIKVNPPNVSGRAELSRWLCERHNEVNQKLGKETFNCAKTDERWKDGPADGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZQ8</accession>
    <name>A0AA38MZQ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hst3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_980256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZQ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="395" mass="43424" checksum="F639A07B0F65BD5E" modified="2024-01-24" version="1" fragment="single">MTLFLPLEESTVPTSIPPFVIKSSEPTAQVAKVIKAILKAKRIVVICAGISVQAGIPDFRSSEGLFQTLKRDNPKDVLSSGKDLFDASVFNTEHKTALFCQMISQLSDLSKAAEPTAFHHLLRALDSNGRLLRIYTQNIDAIESKSGLSFGIPEFKDKRSKPRNTTFLEVGDPGPSTAANRTPRCIPLHGTLQRVHCQICTHSFPLSDYLPSLAAGVPPECPECTSLERTRQLVGKRARGIGKLRPSVVLYNEAHKDGEGVGEVVQKDLIGSKGRSGADLLLVVGTSLRVPGTKRMVREFSKAVHSRGSSSKESTPGSDEQVPQQQQQQPFKTVYMNLDFPVPTREWEGVFDAWVQGDAQAFAQMLQEELDKELHAKEIAIEKRKKKEEELALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZS8</accession>
    <name>A0AA38MZS8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1074215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="596"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3732195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="2291" mass="257715" checksum="CACB7FE1B8DD38CF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0H9</accession>
    <name>A0AA38N0H9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prolyl endopeptidase</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_996596</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0H9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="10">
        <location>
            <begin position="539"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3732676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="726" mass="82309" checksum="1144F662A7C3E5D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1C1</accession>
    <name>A0AA38N1C1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1066373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1C1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="348"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3733711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="708" mass="78444" checksum="FEA68262EE309BB5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1G3</accession>
    <name>A0AA38N1G3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1066058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1G3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="112"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="719" mass="83576" checksum="2B15BCA84999984E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N242</accession>
    <name>A0AA38N242_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_995239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N242"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="174"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="276" mass="30948" checksum="E8ED029DE2DFDCC7" modified="2024-01-24" version="1">MFFIIKGIRSLIKAFCSGSAPQESGEQQQQQQQQQQQQQWRPQQQQAQHAPIMQQPAPVYPPSQPPAQQPYEHHHQTAHPQQHPSPHPQSPQSHRLDPNQDNQHNPHYIDLRKRANEEGDAMAKCFQESHEAYARGDGAGAKELSNEGKEHKQKMEQLNKQASDWIYDSKPGEIDLHGLYVKEAIERSDSAIEDAKRRGDTEMHLIVGKGLHSSGGVAKIKPAIEALMQKHQLVAELDSNNAGVLIVQLGGHSDRAVGPDEIARRLNRDDEGCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2X7</accession>
    <name>A0AA38N2X7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hamartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1214262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2X7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="744"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="100014" checksum="B0EDA87CF61E8DA9" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2Z0</accession>
    <name>A0AA38N2Z0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SecY subunit domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_187354</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2Z0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3733713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="477" mass="52132" checksum="A8D7EF2FCB5483C4" modified="2024-01-24" version="1">MSGFRFLNLVRPFLPILPEVSSPDRKVPFNQKVLWTAVTLLIFLVCSQVPLYGIMSSDSSDPLYWMRVILASNRGTLMELGISPIVTSGMIMQLLAGANLIEVDFSLKEDRALFSGAQKLFALIISLGQATVYVLTGLYGLPSELGAGVCLLLIIQLVSAALIVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTINTGRGPEFEGAIVALFHLLFTWNDKGRALREAFWRDRLPNVMNLIATVIIFAIVIYLQGFRIEIPVKSNRFRGQRGSYPVKLFYTSNMPIMLESALTSNVFIVSQMLATRFPSNILVKLLGVWEPMEDSPQLVATSGIAYYMSPPHTLREAIVDPIHTAIYITFMLSACALFSKTWIEVSGSGPRDVAKQLKDQQMVMAGHREGSMYKELKRVIPTAAAFGGAILGLLSVAADLMGAIGSGTGILMAVTIIYSYWEIGMRESGGPEIAALGDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N364</accession>
    <name>A0AA38N364_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1130437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N364"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="170" mass="19289" checksum="9FFDCBB988FF91C7" modified="2024-01-24" version="1">MNYAGKMSDVVDFGGEADYEHMEWFKEAPPEHLRPRPPPTEPAGAPYMPDSVVIDQNEAFEFALGAAPNVLYARYKQYGQLGVLAWCAEFGELIDNLKELGFAGNMFVSTRTQALKTCEEILKLHLDIGMQIIMLYLSSQVARLRRFLDGDRVWDDYPMPSFPLDPSSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3N6</accession>
    <name>A0AA38N3N6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Composite domain of metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1053960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3N6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="159"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="956" mass="102988" checksum="14A6AB98A172C083" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3Y8</accession>
    <name>A0AA38N3Y8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1058527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3Y8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="123" mass="13793" checksum="7E98EA9B4B73D4E6" modified="2024-01-24" version="1">MASSKKKVATLSDQEIQSKYSQFQSELQAVASKIGELESEADEHSLVLTTLDEALQEEPDRKCFRLIGGVLVERTVKDVVPALQTNRDGIRTAVKGLADQYASKEKEFETFKEDYQIRVVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4Y5</accession>
    <name>A0AA38N4Y5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Caffeine-induced death protein 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1051947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4Y5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="188" mass="21462" checksum="20800C80B67926F4" modified="2024-01-24" version="1">MTSSKPPLGSLAIQAPSLTPQIVHVSPETCMDLSIFKAVLRSYRALDDTINMRLNRTTAFVHDQERQKASRGKMSAEEQACARLWQELVANWSRRRELIEYCVGVVDQSSKTKQEIFDSQTSSPSAIRKARAEMYSQDVKRDQIHKELAVETIVKQRSIDAFRSRCMYFVPPLTDVEARKLWDAASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N563</accession>
    <name>A0AA38N563_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-keto sterol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1045967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N563"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46456" checksum="0099E65010659979" modified="2024-01-24" version="1">MTWPTVVITGANSGVGFGICQRLLCQLSEKTPPDTLIKPQELPGSQEKDDIEGDRFVLPCEGITLIMACRSVQRAEVARQKLLQILDKHVEKLTSSPNYDGHAEIFRKNVRIVIHPVDLSSLDTIPKFVQELEKNYPYVSHLICNAGIAPFTAIDWPSCIHQLLTNPLAALTTPRYYRQSWGEVSQDGYGYVWQCNVFGHYTLYKGLYPLLSSSKYGHHSRVIWTSSLESKKSYDAKDWQLKETRDPYGSSKYQTELISLELDRRALHDIDASKRVRHFTAHPGVTHTNIDLNLISPLLHYLKHFVFYLARWIGSPNHPIALEKGAVSVVWLSIISLSTLTVFCASNKGFKSNSSSNGHGSVRPALKFAAQTDWRGNSCVGVTEIEGGEAHSEEAKELVDHCESLYQSIETART</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J167</accession>
    <name>A0AA38J167_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1162269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000145">
        <property type="protein sequence ID" value="KAJ3710122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J167"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041350945" evidence="1">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="197" mass="21639" checksum="6F4069CE7E3A528D" modified="2024-01-24" version="1">MLVTNICSLAAWSLVLSSVMAIPTPRSSDYDIDSIGMRYQMLSKKSGESTLYYGTCTQNATPIESSGLEEHSDPKPGQLSYKVPHPVTAACAPDARYLTFLPQYSLDIPQAPEYCQDGFSILTRRFEVSTTSVAWVKSFSPHPPPSLWIKFTNGNDRLRKFPNEPSAAGTKNIVDNNDIIIGPGQLSPGEAGRIFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1M7</accession>
    <name>A0AA38J1M7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1044729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000165">
        <property type="protein sequence ID" value="KAJ3709640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1M7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="634"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3709640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1215" mass="137852" checksum="4BB5B0914DF29531" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1R9</accession>
    <name>A0AA38J1R9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_115760</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="JANVFO010000125">
        <property type="protein sequence ID" value="KAJ3711095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1R9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="79"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3711095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="469" mass="50366" checksum="90D1F1E89A11F11A" modified="2024-01-24" version="1">MKASTSTTPSSIPVAHKAPLPPSSSRSSRIAPHSHIKGLGLNAEGRAITDTAAGGFVGQENAREACGIIVDLVKSRRFSGRALLLVGAPGTGKTALACAVSHELGSKVPFCPMVGSEVYSTEVKKTEVLAESFRRAIGLRIKETKEVYEGEVTEMTPSESENPLSGYGKTISHVIVGLKSVKGTKQLRLDPSIYEAMLKEKIVVGDVIYIEHSGAVKRVGRSDAYASSYDLESETYVPLPKGDVHKRKELVQDVTLGDLDAANARPQGGQDIMSVMGSLVKTGRTEVTEKLRKEVNKVVKGYVDQGVAEIVPGVVFIDEVHMLDIECFTYLNALLESPMAPTVIFATNRGNALVRGTQDLVSPHGIPVDLLDRCMIVKTEPYTKEQVAKVLQLRANIEGLKLAEGVLDKLATEGERSSLRYALQLLAPASIIASINDRAEISLEDVGEMNELFLDAKTSAAMISASENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4E3</accession>
    <name>A0AA38J4E3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1205542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4E3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3720200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="67067" checksum="65E9A0E1833C6F45" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4N4</accession>
    <name>A0AA38J4N4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1099766</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000074">
        <property type="protein sequence ID" value="KAJ3717308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4N4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="17">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3717308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="504" mass="55111" checksum="FE49BC51D664C816" modified="2024-01-24" version="1">MFFCAISGEPPQEPVVSTKSNKVYERRLIVKYINENGTDPTTGDKLEESDLIDIKASPETVAPRPPNLTSIPALLQTLQNEYDALVLESFALKQQYNSTRQELSYALYAQDAASRVVARLIRERDAAREALANVQATMGITPSASAPEDVEMEEDTTTEGLPQEIVARIDENHLTLSAARKKRKTPEGYATAAELKTYTAKHTIPSLHSASPAGITSLAVSRSNPNHFLTGGNDKIVQLYDRSTDKVLASLKGHTKKVNQVAFRQKEGEPTLLLSAGADKIAKVWAHDEASNEYIPKLTIRNHKGDVTGLAVHPTSTLLALSSMDKTYSVHDLTTFQQIHRSVPSDEPFTSLSFHPDGTLLALGTSMSTIQIYDVRIGAIAASLAPPDAVPFNINTLSFSENGYHLAAPSSHSTVAVWDLRKQTASTKIELGDDFQINKVVYDVSAQFLGVAGSSGGRLFMYKSWEELVRFEEGGEMSDFVFGDMGKELWGVTGREVRIWGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5R9</accession>
    <name>A0AA38J5R9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pyranose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1158058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5R9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041422326" evidence="10">
        <location>
            <begin position="21"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="12">
        <location>
            <begin position="441"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3723567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="594" mass="63562" checksum="CCB441908AD7746A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5S2</accession>
    <name>A0AA38J5S2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_579915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5S2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="321" mass="34532" checksum="BFBECC7684D579AB" modified="2024-01-24" version="1">MLSSLFSKKNQPETRSESLGHTEATEPKATQIPKGPPQFLAAGIHTLHDDALAELYAKSFEPTDHVAKDSTKAPGSASHSSPGAVPASNPVTREVVRDPFSGHALGTLGLPDLNLNPEAHVPLSDVATRNEEIWSRLSTVLDLQSQIAALHLEIEGIGGKGDQGKGKGKGNMALITSKRPPVRTVSGTADLLDLEHDEGVGVGDDEDEEQRKDREREEDFARLADQFEGRKEGVNSIMLKLDELSKALAEFHALQAPNIQFSSSRHSSLPVTTPTSSIQAIKSPVPLPPVISIPNDRPPTNILSPSRMLDSPDSAESHEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5Y4</accession>
    <name>A0AA38J5Y4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1041470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5Y4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054000">
        <property type="entry name" value="MLKL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22215">
        <property type="entry name" value="MLKL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="1">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Mixed lineage kinase" evidence="2">
        <location>
            <begin position="278"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3725669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121650" checksum="07C24F1F314310C7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J674</accession>
    <name>A0AA38J674_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1086707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3727178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1363" mass="147090" checksum="FD2CFD2AB2BEE781" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6B9</accession>
    <name>A0AA38J6B9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1001946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6B9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000018">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3727253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="290" mass="31644" checksum="C64DF0A570711EAC" modified="2024-01-24" version="1">MSTSTNIEIQKATAERTAEIRESLADIRARVASAAQALAVNSESRKIVAVSKYKPSADILVCYEYGQRDFGENYVQELVDKAKELPSEIQWHFIGTLQSNKAKLLASVPNLHTVQTISSEKIANALNKALPTNRNTPLNVLLQINTSGEDSKSGLSPLSPSSFDSSQLSDVQKLAKHIVTLCPNLHLQGLMTIGALDLSLSANEMERNADFERLKQTRDILVRWLQDGLGSSHDGVNVSKRWRWGDESTGKLLLSMGMSSDFEAALKAGSDIVRVGTGIFGSRKTKLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6L9</accession>
    <name>A0AA38J6L9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000122">
        <property type="protein sequence ID" value="KAJ3711252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6L9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="132" mass="15048" checksum="544E6E221EAB1704" modified="2024-01-24" version="1">MDPKNSQSSHEELQPDQGKSVAHKNRFQIARDLFFACKDYVLKDDRLRNILVDAVSRMQAAVDVTILAALTSDEEIYPTILPFMVIYLSLKYTGQSLATVSRMLLIYNDNARAYATDLYVLTLIFECRSYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6W1</accession>
    <name>A0AA38J6W1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_47340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000101">
        <property type="protein sequence ID" value="KAJ3713232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6W1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041208848" description="Glycoside hydrolase family 16 protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24575" checksum="5B1334AE4CDD5024" modified="2024-01-24" version="1">MIILISLLARLLSVAATTAPTLTQFDQQRFHDRLWQTNLRGPRWTGNDNQNTLTSLVSQSMQLAGLDVQILNYTLDRWDPQWWSLSLALKNGTILGLPTTGYWPYSGDSGVAGVTGPVHDAGTFSVSDVTEKAVNSSLNLDNLPPGGSVLFFDNPSPTHNYSLPGYKLLGTSRDIDAATEIPEVTLFLEHCVCETHRSTPLLVFRLVISRTLTGSLPKHSTSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6Z6</accession>
    <name>A0AA38J6Z6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1172235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000147">
        <property type="protein sequence ID" value="KAJ3710055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6Z6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="12">
        <location>
            <begin position="190"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="12">
        <location>
            <begin position="340"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="902"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="857"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3710055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121598" checksum="9307CB4CC04C706B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J704</accession>
    <name>A0AA38J704_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_58000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000109">
        <property type="protein sequence ID" value="KAJ3712360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J704"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3712360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="539" mass="61096" checksum="9C8EA897D3F4BE0D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7R6</accession>
    <name>A0AA38J7R6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SWI/SNF complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1188779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7R6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIRM" evidence="11">
        <location>
            <begin position="106"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="353"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="358"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3731032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="687" mass="74539" checksum="BA7E0AC229989132" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J803</accession>
    <name>A0AA38J803_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1104339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000093">
        <property type="protein sequence ID" value="KAJ3714006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J803"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3714006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="538" mass="59334" checksum="F6AE24B2721A9C10" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J839</accession>
    <name>A0AA38J839_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1160577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000087">
        <property type="protein sequence ID" value="KAJ3714910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J839"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="150"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3714910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="436" mass="47706" checksum="C3F9738443B08FD1" modified="2024-01-24" version="1">MKYAFVPSPLANSHGLTVAVETVLYDLLGITPNASEDEIKKAYRKKARDIHPDKNRDDPNAATKFQEMAAAYEILSDPDTRVLYDEGGMEGLQGGRSGGPSMDDIFAQFFTGGSGGFSFGFDMGGGPSRFGRQNDSVLPHEVTLEDLYNGKTVKMNMEKQVLCSSCKGSGAKGHAKPKQCSTCEGSGRAYIKTQLPGGQMAVSPQRCEACKGKGENLREKDRCKKCKGSGTVKEKTRQEIFIEKGMADQQRIVLAGAGDEEPGVSAGDVVFVLKVLPHDSFERNGNDLLVKVKITLSEALLGFSRILLTHLDGRGIKVTSPPGKIFQPDSTIVIRGEGMPIYKRPDTKGDLFVLFEIEMPSEDWLRSVDQQALANLLPPKKPEIQPEPKIVDEANFEEIDRDAINDEDWEDEDDDEGDTFDDYAGGGPAEPECRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8I9</accession>
    <name>A0AA38J8I9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1155770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8I9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041452664" evidence="2">
        <location>
            <begin position="35"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="302" mass="34466" checksum="E03AC84D19C19613" modified="2024-01-24" version="1">MLPKSLKSPPSPAYTCLFNLILFWFLNTPIHVRAAPMPSSLRGDPPPYSHDPPAISRVPSSEASSGLRPGSPPPSYSEDMIFRVLNKQNFTRPWMSSVFEHDPAVRVTSEDMAYFSRPLTSYKCKSPPTRGSRNSAICTAQNPNNKKTEVTMKVLQQLDRSALSEVQALAHFYYLFDSGLLKGKPLIVSRQFPGVPLQKTNAWVNHPDQRDSLKEQVRAKVRAQVILWATGDKLFDLHWSNFLVEMTKDDKVKDVHIVNFEYPLLTVNLLSPYTTRGDLEAWFNVYWDYRVDLGHWEIDNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8M5</accession>
    <name>A0AA38J8M5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1079323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8M5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="320" mass="35223" checksum="E23CCDBA93BD1681" modified="2024-01-24" version="1">MDALPIDTTHPAVRDYLSLIRLQVLTPLSLLINIATVVVCAVVVTPSIGEISKQFPTSISPKPIIIAIYVAAIYAGQLGYCVLIVLARKAETKRTITKGVGLSLVIANWVMALWAVAWVFQWFLLSTILQGILLLTLLYSNIVLLIYHQPTSARPFDTMLIHAPLRLFLVLQFGLMFALSLFINLGLTYTPTTPGPPRDYAEHPWPGFGVVLGTNLVGLAVVIIRRDIVWCVSATWICISIWVLRPKPGPVYIAAILFTVLHPLALIGTYIYSRFYTRRTIALPPGDEALYGRTESGRAIAGSQSVSDNGPREVDEDTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8X4</accession>
    <name>A0AA38J8X4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1005911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8X4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041379017" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="24610" checksum="14CEC8934311619D" modified="2024-01-24" version="1">MYLLATAPCVLLSLGLNLVLVRANPIVQRQRTSQQCGQGGPYFDPRDNGGSMLDASAGLGEPLNVIISGQSSPNVLDATGKFLNYANAIGFLCLGFHIGNPQQANLGDGRGWVNQTAVVRQDYGNSVFGTCEESVIGGNHFRIYQQQGSCALFLAVSIEEKASTNHRIEPNGYDAGRDALVAGAIGKREFDGVKYTTTAQTLEGLLPVGSQGIDQDIAIDGRVVLLTVTVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J930</accession>
    <name>A0AA38J930_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1077741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J930"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="422"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="478" mass="51518" checksum="FB020283CCA6058A" modified="2024-01-24" version="1">MVIDYFLSTLMSTTQQFRTERDTFGELQVPSDRYWGAQTQRSLQNFDIGGPTERLPPPLIKAFGVLKKAASIVNVGYGLDPKIGEAIQQAADDVISGKLNDHFPLVVFQTGSGTQSNMNVNEVISNRAIESLGGELGSKKPVHPNDHVNMSQSSNDTFPTAMHIAAVTEIHRSLVPALSELRDALDAKSQAFEHIIKIGRTHLQDATPLTLGQEFSGYVQQISNCIERVKAVIPRLSLLAQGGTAVGTGLNTKKGFDVKVAEEISKLTGLEFKTAPNKFEALAAHDALVEAHGALNVLACSFMKIANDIRYLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEALTMVAAQVMGNQTTVSIAGSNGQFELNVFKPVIIKNVLQSIRLLADGARSFTKNCVVGIQANESRIKSLLNESLMLATILNSHLGYDNVAKCAKKAHKEGTTLKEATVSLGLLSPEEFDAKVRPELMLYPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J965</accession>
    <name>A0AA38J965_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_344711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J965"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="182" mass="19502" checksum="577063A452A9CECC" modified="2024-01-24" version="1">MSNVGNKVKGAFNTVHGIGENVRATALGAVDTIAHDKEGEVKNDQIAQQGRMETQRGMEQMSGRQQNANTMANNYNTTTADPALANNTIANTTANVSASDYPRHHRDNEVYDDSQAQRVYDHGDNMPSQAGYTNAVGGVPEPSGNTEYGAGYGAGYGIGNNNVLDPRHDVGNSQNNNGNRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9G1</accession>
    <name>A0AA38J9G1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1075705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9G1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="510" mass="55057" checksum="D577CB0B62CAD511" modified="2024-01-24" version="1">MDNPQYYQPLSHALINPPRSSSQSQFYKTPSMDQQAPSGEQQKVVESDDDDEGMVEEQLSRTSAPPSPKPRAALHEPEPRRRGRPKGSKNRRGRISSQTVKSSPPSHQQLHATGQGTNPPQLPEVTAQNQQYYEFQWRVLNLCAEFYGAAEELVKGTPALVIAQCYQMGPSSKVDPLSMLSEAKQNCDTLLANPSRLITSPPPPMYPVVPTFYSASVPPGPMTSSGIPAGAPTMISQPQTFVVPMGNHAYYGPPPSQYPTTSYYSYPYGHPGAYYTPAVAPPPAPPPATPTAPPPTPTVSITTSVTGNSGAWSDEEIERLKSLAEEKRTNSGEIDWDDITSHWGSTRTRHQILIRATQLGLKESSTVRGVKRRRETDSNGDPTSTTPTPTPTASASAARNPSSTPSSTPVASPSLQNQQQPSNPNSKAPAPISTTPSTSANQPWPMPVVAANTSSPVIGSSASDHRVTSYYRPRLTDPSSRPSSSTGTSQLPTLHRYMYQPNGHHSENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAC8</accession>
    <name>A0AA38JAC8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1159267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAC8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="304" mass="34691" checksum="77F2D6B463250568" modified="2024-01-24" version="1">MDSYSPNLRKRQPAAAGSAARRPTRGLPTLHSDSSASLLTCLPSVAPVGGDKALPARPVSNLRDYMPPCASRSSWSGMPFAQFERRLLHNDQPGDEPDVSELQAFLSSRIKEMNRQRAMLSLPAWKVPKSDLLLMRHVCKLWWGEDVKIPEVKKIGIGHDVKYEIDYESMATAQELEEILLNKPLIDISTKDEQEEARKAEERSWAQTDALIKLYNKRYGPYGVEKPVKTKRRDRNKPSAFVKFWGNVGHVFGISTRRSRRNSNRASVGRRRTRLGVRVLRRLRQNSHYSVTTLRPLDDDRSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAS8</accession>
    <name>A0AA38JAS8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1079511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAS8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="191" mass="21013" checksum="3880D5A99B1677C3" modified="2024-01-24" version="1">MHLPIPCSSPVEISSFLGFSPKFTNSSPTCSLYLLTFIGLAILAVAVSFKHFLARKSRTKQGQLANHQLEKERTQTFQRRTWITFINGWDGIHWPVTLTVPPTSTSVGRGVGLNGAVLGKQMSQPIRNNSSIDPLPTIYQSKEPISMAKMIMSRHTFRRPSSPVQTTSQATTRHSAALPLSPAPSKPQSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBT9</accession>
    <name>A0AA38JBT9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1124769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBT9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041318875" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="36"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3721316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="207" mass="22698" checksum="E8D509BFE53F0896" modified="2024-01-24" version="1">MQFLSFSIILSLASHFLSAIADQTPFHQPITDNNNMPSLADLLTIESSASIFYSYARELALSEFLSEPASFSETSGRARNGLTLLVPTNKAVMALARKPHQGPSPKDNDEDITISEEEFYKKSKDNVQRWVEAHIIPTSPLTYPAPTTTYDTLLHGKSVTLTSSSGDGQGNEDWQRVTIDDGIRILSMKQASNGVLYLIDGTISVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC52</accession>
    <name>A0AA38JC52_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_732502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC52"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3719612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="480" mass="55992" checksum="3F0A2AA7BA6F4CBD" modified="2024-01-24" version="1">MGYARDMLSYGLPRSHVVNFLVDSQFARCIYYDRSLILESKVIFAKMVKHMGNLPLEDLGFSPSLEANFIRDPASLMKLEKPAAEEFPSSRILTSLEGSSFTFPYQNNQTRTVRLKRVIFRSNGVIGRGTMVIRVTCACRHCPRDACDWQAKKLVLKLSFPSATRVSELIFMDRCKQLAQGEHAWVMNHLPDIIWSFDIPFRTDSPQDALSNEFGATYEKRVMRGVIQEELKPLSYLQTAKQCAQVFYDVFQCHHWVWKYPKILHRDISQGNIMVREKNGTIYGVLNDWDLATWLDNKRDGPTSLFRTGTKPYMAHEQQTIHWRGPHRYRHDMESLFYVMVLFACLYSSPKEKVPNFEDKDFRLEEWHRKDDEFLRRAKTTVVHAASFMPPVSPFFIDFLLWLTELQERLALGFVHLMIHIKQAAKQKARQPNTLPTFDMETLGDHFSCEQIAMILHMFDNEQLTTRGLEWQNILEGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCF8</accession>
    <name>A0AA38JCF8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1064579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCF8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="332"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="414" mass="43936" checksum="93747BB3C060CF3E" modified="2024-01-24" version="1">MANPEQEEQIEEQFITEDDVLAEVPDDGDQLMDEDEENEGEDIVGELVPGSSRSAEDNSLQAFTNHHSSVFSVAVHPTQPLAVSGGEDDLGYIWDITDGEVIVKLSGHTDSVVCVGWSFDGQIVSTGGMDGKIRLWRRVGQESYRTWEFLTELQGPDEVMFLKWHPKGNVLLAGSNDTTLWLWQLPSGNTMQVFAGHTGPVQCGAFTPDGKRIVSACGDGTLILWDPRSPSPVFKLTAEDARFDLDGITSLGINSSSTLAVVGGAAGGVRVVSLTKGEIVSALGGHTEGESIEAVEFIDLTGTVSGPGIVATGATDGKICLWDLSTMRLRSTLEHSDAVTTLLAVPAPNNHLLVSGSADKTLRTWDARTGALIKEHKGHQGPVLGASLGLDGSVIVSAGDDGVSLVFTTELEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCS9</accession>
    <name>A0AA38JCS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1004929</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCS9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3720284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="534" mass="58933" checksum="ECBCF0B4AB046E8C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD36</accession>
    <name>A0AA38JD36_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1121842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD36"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="441"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="801" mass="90850" checksum="8D62755EC1920883" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD84</accession>
    <name>A0AA38JD84_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1084533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD84"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3729051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="517" mass="57231" checksum="22D5DD22CB802086" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDA9</accession>
    <name>A0AA38JDA9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_238673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="100" mass="11391" checksum="18EF0FE1927FFE6D" modified="2024-01-24" version="1">MLIRCSTSIRFHSGRGRYLVSWALLESVTASGTGAMESNKYTQLSTPTLVNLRPSRTAESPLQQSWRSTEYDSSSSAHRFCDHCRATKFRSHHVQRRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDR8</accession>
    <name>A0AA38JDR8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-methylcitrate dehydratase PrpD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1093161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDR8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="269"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3722758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="51857" checksum="68C1EAA2C1E2A07F" modified="2024-01-24" version="1">MATQQLATWAVDLQYANFTAPVIAAAVTSLYNWAGCAIGGYQQTAPGIALNATSPHFGGPPTSSILALANDSTQTDAQIAAFINGIAGHVDDYDDTHLATIIHPTGTVASALLAVAEWKGGVNGSDFLTAFIAGVEAELKLGLSVWPQHYDVGWHDTSTTGSIGAAVAVSKLLGLDVPTMQQAIGIACTQVIGMQEFFGSDTKSFHIGRAAQGGMIGALLAQSGFTSSLQGLEAQFGWVHVVSTRENVTAEFDTLGKSWEILSNTFKPYPCGIVMHPSIEGAIEVQSTALGKGLNMSDITSVQARVNPETLVLTGQTDPETGLEGKFSVYHGIAIGLLFGEATPSQFTDAIVTNSTVVALRKLVNVTTDASVREDEAYVSALFKDGTNVTQHIDHVIGSLDNPLSEAQLKTKFIGQASLVLGEARAEKAYEAFTNIGNMSDVSTIAQLFAGANGTSNSTNSTTSASGSSGASTLYFVGPNGVASFTVIAMILGIVALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE31</accession>
    <name>A0AA38JE31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1002418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE31"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3725659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18137" checksum="0B02B14140775A13" modified="2024-01-24" version="1">MSPQVDEETPLLQVQQHKPERTPLPWFQFTIVLFLQLAEPLTSQVIYPFLPQLIRDIGITQGDETRVGHYVGLLQSLFFLTQAMTVHWSRISDRIGRKPVILFFFFFFFFFFFCILFIHRCAVAYSSVKSSVNVLFVFRILCGCIPPTNVVPLEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE84</accession>
    <name>A0AA38JE84_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_647456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE84"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3723576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47358" checksum="7CC08602094B44E7" modified="2024-01-24" version="1">MTFFRFFDLFQHHHNSKLDVSFHPIIPQTQLLNPILSVTEQCLPSRIPLEVIMIIMEAAYDQEDVESNRGLLRSLALVCRDWSFPAQRLLFRHVSLDSQAHYLSFASATNQSTERGRLLGDAVYSMRASLDPNQPGRLSQLNFAQAVTRCPNLHELGISLYGCVPPGDDIVGSPDSSRMRRPAPSFDEDALALLRSGPSINTLRFSNWSENRQSITQLLNVWTSLKILVISGTPPELPSPVSEPFPCALEKLRMNFQTSPSVDFLRWLLLNSGDTLRALEFEREPSTTVLHYLIHTHHAMLTSLSLPSCSRATARVLDKCTSLRNFFVEDAISFPVALKKLSPRFEHVGFGLNKETSLQTILEAVKVNQSLQTVSVNIWNGGKLHRQLPSLKMACASRGIHLRITHDIQVFRGIVRGEHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEH5</accession>
    <name>A0AA38JEH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_806688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041422328" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3716710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="94" mass="9855" checksum="0449A7070E7E2C30" modified="2024-01-24" version="1">MKFVAIAGLAIYLSISSVSSVDLRREIYTLSVFCDAWNKECAALANGTGDGFSYCESGYDGAGTASADCYSYDGSTTTDYTESVISSLNAVAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEJ6</accession>
    <name>A0AA38JEJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1214896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEJ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="20723" checksum="93523EC2D6FE6BB0" modified="2024-01-24" version="1">MSLCVLSLVAAQSSSSTTSSSSGVGSSSTLGSASSGSTIASTTSSGSGPGSSLSASSTSSAALPSLSGYDTCVVTCFETAIAQSSILFSKILIRTHISTDYQNALVSCMRSNCPSELVTAEGLTNKFCALASTSTSISFSITSLPSSSSTSSAAPSAGSTSASGTSSLSSTSLSSSVSSTGSSNAALGVIIGGGLSQAAVPSIVAAAIGVVAGAFLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEL9</accession>
    <name>A0AA38JEL9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEL9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="349" mass="38853" checksum="05C2DB41624F39DB" modified="2024-01-24" version="1">MTTRNTVNPGKDGTPTQTKIAFQTKTNPNSSTRPPSPTHTENETEEFQVLIDKAVAWKLMSRGDDCNVALPARLLQLVATVKESGRSRTALNETLDKIALAAKILQEWSWKDKTEGRRTELMENLEEELTQKTNTIGKKVKGIAAEAQETWKKLEEVTNAMTEISTKIATLGNTLPDNHHQNETEDGELTIRPTNTSYAQAARAHTFPSLTNHHTHQHNTAVREAEMKDRRIVITSQTPSDWALGEQELVMKANMAIETIVADEGAETIKPEVVAAMKIASKGAFLLLRNTEEVNWMKREGRMQSFEAAWGSSATLRPNYAEVVVEALPMETPINSPIEQRKIEMASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEP1</accession>
    <name>A0AA38JEP1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1056189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEP1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="192"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3735652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="330" mass="34874" checksum="5AA4B56EAA109BE0" modified="2024-01-24" version="1">MSTPVDDLPRRFGWVGVGAMGFPMASQLLQKLPSSHQLFIYDVDTAVLQKFIQTNADPNRPTITILSSPKEVVEHSDCFISIVPEGSHVKDVYLAPQRGALAADTAGKIFIDCSTIDPGTSLEVGRAVAASQSTNAPRFFDAPVSGGTRGAEKGILTFMVGAAEDDPQFPLLRRIFSCMGTSIYPIGGQSLGLAAKLSNNYLSGMIALATSEAMNLGMRLGIDPKVLSDCFKTSSGGSWVNSTVNPVPGVCPDAVTSKGYEGGFKVQLMKKDISLAIQAAQGIGAKLVLADAGLSAYASAADDPNCRDKDSRVVYRWLGGIEPDVHRASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEU6</accession>
    <name>A0AA38JEU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1156716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEU6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="95"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="280"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3728147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="467" mass="51103" checksum="2C430717C93D9D19" modified="2024-01-24" version="1">METPAPLQPDEKATTLTTLSQLLVSIEESTAVLRESIEKQLSSSSDNLDFSEIAASTLHLQFHADASVALHASKLRVACERLAQVVTPPRHLVFEAAGSFYLTAALDITVKSDIATIIHTHSSQSGAEGVPVDVLAQESKLDSDLLARLMRHLAVFGIFKEISLNTFANTAASSTLINNPEFRAHLDLVMHEGRAAIPFFPEIVSKRYSDAVPPPSAFFLYSNGQLFYDWLHSPSQTDRNANFNIAMRGMAHTEGLAFLPAGKSVPPFSDYPFHALPADKVIVDVGGGIGSLPTILLPSLPDHSFIIQDLEPVVNQAVEGASLSMKRWMDQGRIRFLVQDCFTPQPPELDGAVFILKNMIHNYPDSRALAILSNLRKTNPYKLLVIDRLVIPQLKSDNNQSLTVPHGGTGSQRAATFYDLVMASLHGGKNRTLEDWRKLLEQGGFKLEKIYPLRASTGQAVIEASCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF67</accession>
    <name>A0AA38JF67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1078008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF67"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="356" mass="37786" checksum="447BEBB8396D9A3C" modified="2024-01-24" version="1">MSSPFQSPDIKGIFLLGATGYVGGQLLLSLAHDFPTFPVRALVRNVSPSKVVQLQSLHSKLEVVEGSLSDVDVLEAEARKADVVIDVAAAGDTLSVNAIIRGLQQRTQSATPTPSPIYIHMSGTGITGDNARGELLAPERLWVDTEFSLDYVKSKLLASACEAIIDAGESGEIQTMIVFPGLIYGVGPGLQKISLPHRIYLDLAAQAGHSGSFGSGRNISGFVHLNDVTSAVSAVLKGALHGGKTGEKIGQGKEGIYFVLSKHMVSMGEFNSIIGDTLFKQGLIAKPGFSPFSASIADKAGAFGYTIFGSSTFCRAERLTKELGWSAEHTEAEGLYESLPKEIELAVKEMQLVFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFB2</accession>
    <name>A0AA38JFB2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1097676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFB2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3719037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="109" mass="11927" checksum="AD07422E7B814046" modified="2024-01-24" version="1">MYSSKSWVNLGCAGWVSFPSELRAVYLIILLPMSRANCCSHAVGLVGGTRSYVLPSNLSVLTTSSCSNHGGTQHIFCKQVIILTCINQVRDDWLYGFRCISRNGAADHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFU2</accession>
    <name>A0AA38JFU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1227008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFU2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="711" mass="79935" checksum="4577F2A39B314B00" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGJ8</accession>
    <name>A0AA38JGJ8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1182515</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGJ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3732139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="491" mass="55428" checksum="214CE7A4EEB184EB" modified="2024-01-24" version="1">MYLDSSMVLQLYLCAVFGLASLFLVRWKASGRFRKVASSPPGPPGLPFLGSVSLLWERKPWLRFTEWKDVYGPVVQLRIFGKTIVVLNTHEAAVDLLCRRGRDYDGRPRSILISEMMTGGLAFPLIHGDLWKRHRRAAQSVLNPRAVEQYHGNQERHSKQLVQDLLQDPEEWPEHIKRSLYSLYCSVGYGDANKDRASYRIRNFIGRIVHAAIPGSSATDFFPVLARLPTWLSPPKRHYLAQFRADNREFVGMVSSLGSDVTTGDSMVTSLHGTNEMSTSECAWLIAVLCAIGGEVTSSVLPTFLLAMALYPDVQRRAQSEIDNIVGKDRFPTFEDRHKLPYVQAIVREVLRWRPIGPIGFPRSCLQDNYYGGHLIEAGSIVVPNIWAMNRDPLLYPDYDEFRPERFLNFEHDVPGALGQGHVSYGFGDRICSGMHIANDALFINIAVILHACDITKRLHCPLTKDVFEDFGIVTRPGIFPCQITARNNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGZ5</accession>
    <name>A0AA38JGZ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1154989</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGZ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="277"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3731922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="352" mass="36820" checksum="875968BC639A3120" modified="2024-01-24" version="1">MPPRGNEGLDFTPIVTHYLFLFTSLLAVLAWFIAFIGQIIATAARGNGDVGVLWFAIFLQLALILGVLYTLASDSIAMHRFQISVFGAVSIVFAVNGVQAGIFTGIGSLDAMSVGWLILAMVDIVWVLYFTSEEDSLALHIFNSMGTGGLTPPSRRRRTRAQSVHNVTNGYGSYASGGGIGPHDMPYNGKMASGMGSGTLASPIGTGNAAVRSQNSFGPSADAANRSLGGGSINNALSGDGPGSSGGGENGPSSPLMASAGANLTQDSPADPAGPETYTYKAKALYAYTQSPDDANEISFTKGELLDIMDKQGKWWQARKSDGTVGSELFLIHSSTVVKMFAVAPSNYLQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHW9</accession>
    <name>A0AA38JHW9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1079398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHW9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="136" mass="15719" checksum="81F5E2C31362C00E" modified="2024-01-24" version="1">MVKVYKPGKVAIVLQGRQAGKKVVVIKQLDEGTKDRPYPHAIVAGIERCPRKVTRRMGQKKLATRSKVKPFIKVVNYSHLFPTRYQLELESLKGSVSAETFKEPSQREDSKKAIKKQLEERYTAGKNRWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI43</accession>
    <name>A0AA38JI43_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1155332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI43"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40407" checksum="03D40ADCF9C6DAB5" modified="2024-01-24" version="1">MTTVIKSLAKIALAKPKAELPKLPEELWLDIFRHACGLSDFCDAPRLLSFPVALPKKLLLRRMKFQRRIILVCKAWYRIALPCLYEEIAVLDNAGLHAIVDCLLKHLLGHSTKRLDFFAEEDVDEETFFALLDRLDNLKIVTIASSVSASISKRIFALPNLTVFCNTWNGSLQFPEPTFQKYVFRAMSFPGYNGEFPSVLSELSQIYFPHSVYIVDPEELSILCRNLQSATSILFGYGHGQCSPLMTWIFDFLPNLHYIGIQTTFQDFFAAEDSINAFPPSVHTFGLIFQNPKAKTRTYRRLCEILKQIQGDGLKVIRLGEETVHDLRSRPSAAALVEETFMAKGWRMEVGDQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JII3</accession>
    <name>A0AA38JII3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_367100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JII3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="87" mass="9206" checksum="301A41230463765D" modified="2024-01-24" version="1">MSYVIFGRAIKNEYISLGVLGSVFGGAFLATRGGSKQEAKSATPSVIERVKEAIPLNAGSSEEEELMNSIRKYIAEAEKEAGGSGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ67</accession>
    <name>A0AA38JJ67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_994630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ67"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="113" mass="12691" checksum="49B8CC2F86107DDB" modified="2024-01-24" version="1">MSNPVRSKFFVYAPDKTEEGTFAKRLSVRTEHLTRMKTILTEGTIRVGGVLLSPESLTAPPENQKMIGSTFICEAESLDDVKKMVEEDIYYKEGVWDKEKIVVLPMIAATPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJE6</accession>
    <name>A0AA38JJE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1048589</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20341">
        <property type="entry name" value="BRcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23134">
        <property type="entry name" value="RING-HC_ITT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000051">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="17">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="186"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="190"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3736961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="462" mass="52008" checksum="0EB3616E4607C823" modified="2024-01-24" version="1">MPETGDSGLVQECLDLQKEELEVLESIYPDYVSGGISKRSVKLEIPVELASPHQIFIEEATQTGSSTSSIESLTLSLLPPLLVHVILPETYPLRVSPQLLLIHATHSWLHDTSRLQDLIVQMWNKQIGEGVLCDMVELIRSGTFLNELEMVTDHDAILLQHNTPESLAPLLTSFEISARSDEFNQNSYSCSICLTSLKGSKCSQLSCEHIFCRCCLEDFWSLCITEGDVARVGCPDPECVKAGRQANEEEVRRVVSEEAVARWQWLQEKLMMERDPSISICPMVFCQKPVPKPLITEDEDSGWHRLRTCPSCSYSFCSFCKRTWHGPVSACPISAYETCVLDYLALPEDSPGRRLIERRFGRSIVAKMIAAYQEEQAFKQWLADSSTPCPGCNVHIEKSLGCNHMTCSKCKQHFCYRCGTKLSATSPYQHFSIPGSKCFNKLFDFINENDGWQPIEGFDAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK65</accession>
    <name>A0AA38JK65_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1182590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK65"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041431275" evidence="6">
        <location>
            <begin position="19"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="89"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="479" mass="50736" checksum="55A6CBC19DCAF08F" modified="2024-01-24" version="1">MLFSSAISLAAALSLVSATPAIRRYVSSAAPRKPTSPLPAADYSVPIVASVPRSKAKQSLLQSLRESQAAKAGSNFTTVLAGSDFDEEYLTNVKFGAQEFMLIIDTGSSDTWAPQVGYACFNLENKPVSQSQCAFGTAGFDTNASTTFRTDPGTNFNIEYADGEFLSGTVGFETVTVGNMAVANQEIGVVNKAAWDGDGFNSGLIGFASPNLTFVFNGTNPNDDDTQLPYNPFFYSAVQQGLVSHPFFSVALNRGSFAAENSSDLDPNLGFIAFGGIAPVEVTDAAVTVPIQGYNAATFTPENGTDVTYFYYAVDVERMSFTGNDLVFGTTNNIILDSGTTLDYVPTDVADAFAAAFDPPAIKDDDFGVYTVVCSATVPEFTVTIGGVSFTVDPADNLFPLGIQDDEGNDLCASGTFDGGPSTGAEGNVFILGDTFLHNVVATFNIETDEITISQRAPYTSESNNARRRAPASVRRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKV5</accession>
    <name>A0AA38JKV5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1154728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKV5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="440" mass="51349" checksum="2C4FEDC21F3E46DC" modified="2024-01-24" version="1">MIFWPIEEIGGTVELSRRPPEPPTWARLRQWEDDLPQHDFSLPFPEGRTGRYVKFDNQIRMLGWNNVLNEVLMNAHLSYVSGRSYVFLDYYWKADYYSWPKHQFRTDPPRTPLNALISGPAAGGPWDEGDEAPRAISERWYEVVCPYKERRFINTREFKPAVWNSPGIDMLNHWAQVLRNAPERCIEIQGDDEHDMFPQVFDLWMWGSTRVLSLWEEFSKSPVSRLLQTSPVVKSAVDANEYLFYPRGSRLPLSNLGPRDPYDRMMAIHIRRGDFKEACMRLAYFNSTFYSWNLLPQLPDSFEVPPSMIWNSTEYNQYYVERCFPEQQAIANKVGEARKAYITAGKHGKRTLDVMYLLTNAKGAWLETMITYLKQDGWHTIVTSQDLELNAEQTDVNMAVDMDIARKAAVFIGNGWSSFTSNIVHRRLVDGKEPLSTRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMF4</accession>
    <name>A0AA38JMF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1117855</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMF4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016216">
        <property type="entry name" value="Monophenol_mOase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000340">
        <property type="entry name" value="MPO_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3733060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="616" mass="68040" checksum="F62E20914722D0E1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMM4</accession>
    <name>A0AA38JMM4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1067052</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMM4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000021">
        <property type="entry name" value="DIS3-like exonuclease 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="16">
        <location>
            <begin position="68"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="17">
        <location>
            <begin position="512"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="324"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3733858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="993" mass="110924" checksum="39AD7854F941A5D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMV0</accession>
    <name>A0AA38JMV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1131013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMV0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3733993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="393" mass="44622" checksum="2ACC97B9E7A4930E" modified="2024-01-24" version="1">MRIPEYLPQTNQTGEIISITTAAADVDPNHSLTIYSDSKTTIDGLTRNRQRWEDNGFAGVANAKELRTTIATLRRRNTPTTLKWVKGHSGLEGNDKADALAKKGSEKAEQDEVDLLIPPNLCVTGAKLNSTTQTRAYKTIRQIKMSKKQYQKAIDRRNTKINTGRAKSVVKEIMGSEPSNKILWRSLRHKDFSRKFRYFIWMVAHEGYKTGNYWQNISNFENRANCHPCGVPESMDHILTECQCPGQQQIWELTKEICTKKGIEWNEPSLGMILGAGVIKPNKREGKPSDGDARFLRIVTSESTHLIWKLRCERVIQGRNSPSPEEVTRKWKKSIEARIGLDRLMVTAQFRKRSLSKGLVERTWRSVISDEDNLPEDWTGEAGVLVGRRSGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNC3</accession>
    <name>A0AA38JNC3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1059447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNC3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="298"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="343" mass="39421" checksum="8542594E94595C3E" modified="2024-01-24" version="1">MLDTHQEREILDLYEIALLLNYERTSSEPRFRYTKLREVASHELDFQTLLINTPIWTAHKGPKDGFVFQRMEPAVIADSGSREVPDLPSNMLPQIVYPFARDITQLAPDRLETIYWQARGHDSCFKSVAILQHFFDLYTTDPFIRIRLADGKEYFSSPSTRSIIEYELLTVQRLTIAVVLPENKAYATGSADQPRFKHAVVVFESHSYNGGVQTVLDLASMQFGDTGRGPGHSGKGTLALESLDDYHNRLSSIAAGFRTTKISYHITPDPNEVNEAWMKKVAERAKERWENRDDHHWCGHCARPLANGPELKRCSACRDAYYCHREHQIKAWFSHHKRWCGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNJ8</accession>
    <name>A0AA38JNJ8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_990902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNJ8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56841" checksum="B189201EDD60A26C" modified="2024-01-24" version="1">MLKLNSLFRGRNVYHGWWKRVLHKPQSYPITTTSHIIPISSIKVPSRAQKNDGAILDFFSTLDPNVSHDLPARFADLKAQIWHKGLLQAWKEVLAELETETERIASLGAKVIPRISYEELRAGLSKDVIAKVKQTGVVLVTGAVSKEEALAWKESIRQYIRSNDNLVRGLPYDDPQIYELYNTQAQTLARTHPAILETQRTLLSLWHTSDPSTQINLHTPISYFDRLRIRKPGDTSFTLGPHIDGGSIERWEDPNFRECWNKILEGNSSWREHDSFDASPRVRANQDLYNAANQCSIFRPWQGWTSMSTTKENEGTLRVLPMLSLATAYLILRPFFQPRQSESYSLRFEDWKVDLSNPLFPGSGMGKGQELNESTHPHLKLEKTMTAIPMVEPGDQIYWHCDVVHAVEYQHKGMSDSSVMYIPAVPLTIHNAGYLRDQRIHFEKGLPAPDFPGGEGESKFVGRATKEDIRTISGRQAYGFEPFEEISPFMERVNTIITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPR4</accession>
    <name>A0AA38JPR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_154920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPR4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="960" mass="106551" checksum="D1B2568D7E50D20D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRH8</accession>
    <name>A0AA38JRH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1145952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="575"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="813"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1338" mass="149216" checksum="88F9A7A4238D8ED5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRJ2</accession>
    <name>A0AA38JRJ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1035629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="289" mass="32948" checksum="73E2ECF83DAE3BFB" modified="2024-01-24" version="1">MSSNNSRSNSPSDEEEKAELLLIQKKKEERTRREAEQKAEEEAEAAAEARLAEIQAKAAEAAKKAAEKAKKEEEERKVEEESRLAKAAKRTADENRKKLEMDRRMETAALVRAQIERKKKEKQMSSLASETSTVVVGKKRKRVVMVAVPSGDPEGGDPNPGDDDDYVESDSDDDKGPEDPLLHLQNNRGCRKAKVRCSLVPGDYPRRSKRTKVESPVASTSSQTIDDLRTNVRDLNTRINLQEEMLRYLILRVRKLEEEKREEDEEEEEESEEDRVKRTGDRKGKGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS87</accession>
    <name>A0AA38JS87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1060633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS87"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37954" checksum="477E097D92FD5536" modified="2024-01-24" version="1">MHDHDENNVPLEYPHNLAALYPNKRCKTPPESAEKSEQGMPVAEDSVEKNDDRAAATSEVTIKEAGDSLEEPTGERQRRASEEPAFSRSLHEPLLPVTSETEKKDAPASKPPAVKTTPTSQAFAFEGFATATPASFSFNNGTLASGADMRPTWSSTNSFRKRHSFVERLDDDLSSSKSREPHALGLNSPRDAPTYTHVTGEEDEDVQCELKGVKLFVKRGSNDYSSGILGQVKYLLDKRTLVQRLLFRREPLWKISMNTRLQPTVRCTFDPQECILRLLLAESVGSKASGATEIVVYALKPGRFCSRKDFQKFAESVIGSSNLKTTEMPRASDEGSSNGKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUD4</accession>
    <name>A0AA38JUD4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1128734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUD4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="501" mass="55895" checksum="12DE5885F6C2CA4B" modified="2024-01-24" version="1">MAFAQDLPFDLIQPILEHLTDRTDWNSCCLVSKSFNKVAIPLLYQTLDSRIITQSKSRNSHIDSNNSKPILYHPATTLLSRPSLANHVRHVTETGAVHRETLPRYATITDDALKALALCTNLRSFTWMDDTMNDIVRGNPIGGHSGLPLRSLTIRTHSDLGSSVWDSLNSLSGLTRVSVWSMDGGWSLALGSTLEELELGRCAGVPPTILVTVISHLPLLRSLRLKGVASNSILDLLTYLPLLDNLDVEYLPSRTRLHPRDQARLFMLPSLKTLTVRSNSRIDAFDPLKLYDWIRLLASKEGLQAFKLHAFSLSLPPTSPAPSFSAPKSYLFLPNASSYKTFSFRDLGQTLVPRGFILDLARLHSASLRRWEAAEAGVMMISDVECLCVSFPRLKVLDCAVGLEDVDSIYHAIRSAHNLTTLKLHIQWLPSSSTVKWRSPHFADVASRKHRSLDVDWSEDEDEDKSLLRTIGVGGILYQGLWVVSNHEDVEFVVTSNVKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVX0</accession>
    <name>A0AA38JVX0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_994538</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVX0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3733838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="509" mass="57309" checksum="E75FA167C027E384" modified="2024-01-24" version="1">MLASVSVLGKRKKSASKSKGYILHLNSSPEPQTGLSESEHEPVSSSKKPVLVNGQSVEGNAKKRYYCTVEGCGKAYSKPSRLEEHSRSHTGIRPYTCTTCQKSYLRENHLQAHARTHLPASERPFICSLPKCEKRFWTQQHLRAHADWHKGLKTFPCPEPDCNEDFAKHHQLRSHICSVHSPSGTKPYPCSHEGCTKSFDTSQHLRTHLRVHNDKRYTCVNKACLPTDVHPIIFYPTWTALQHHTRTAHPPTCTHATCNGREFASQKSLRAHQKIHEQRDEEAQLDAIIAESDGEDEPPSKKRRGGEHGRDWKCEIAGCEKDFKSSKALRVHHAVCHLGRRDFKCPRETCGATFGYKHLLQRHVARLHSKNPDNSSTDKDDVNQNAGFGSDVTASESELDSDPIATKPIMGIGAITGSAYSNRAQELLDATKAIRCPYPHLQELTLVRSEVPDGNVIGPDMMEKATTSLQCDYIFRRAYDLRRHLRAVHEMEVEKESADAWVSKIKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K049</accession>
    <name>A0AA38K049_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_990170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K049"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="421" mass="46169" checksum="A2F1866310F7388E" modified="2024-01-24" version="1">MSNVKAPAPIHLLRSHTSSIAVLFISRDNERVYSGDASGYAVSTSTRTLRAIASWKAHEDGFLGIEEWENTIITHGRDNKLHVWNRPDDTSITSGIGSSAALPGLSTPVLWFSMDVNALNYCRFSLLPASFIGSTSLPESLPSASTSKVDSASECTALIALPNLIESSEADVWSIPSCKRLHAAIGKHAKTTIFYGDGRAGENPTGIIMSLHLFETASSSKSTPELRILMSYENGNVALRRYANPEKSMSVEGKGWEVIWETALHREAIMAMQVSSNNQFALTVSADHIIGRYDLTVSKDASTPDGSTIHRTKHPGNACIAIRDDGRVCAVGGWDGKIRLYSTSSLKPLGTLKYHKDGCQALSFATMIRLDPGSRYKEQDRDADEDEDMLDEEKLQRGRWLMSGGKDKRIAIWELISFEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQH5</accession>
    <name>A0AA38MQH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1008938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000121">
        <property type="protein sequence ID" value="KAJ3711271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="54" mass="5793" checksum="0C52B697B5367491" modified="2024-01-24" version="1">MCYRSINCTQFACGHLIPIDGGVKVDCNQSNCVNSRVHAAKGACANCANTCSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MQP0</accession>
    <name>A0AA38MQP0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nonribosomal peptide synthetase 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_47166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000101">
        <property type="protein sequence ID" value="KAJ3713227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MQP0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3713227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56123" checksum="0EA8C21E2A9135C1" modified="2024-01-24" version="1">MSTNEKHTENVLTLPNLSSDDNDITPSSTSPPNSVHSVDIEKKASEDHVDLEQVNLSLPAKLGHSSFTRWLYLIAFSYYRKTFTVIFVANLIAFIAFVAQNQGTPSAENVGSAASANLMVTLLFRQENFVNLVYELATDIIPLSAPLWIRRRLAKVFHYGGAHSGAGVAAVVWYIMYTALTTKDHIAHPTKWSLANVVTSYILVLMFCFILGGAHPRFRRRFHDYFEAIHRYSGWVAVCTFWMHQCFAGNQYRLLQPNPPSLGRYLISTSGFWTFVISSCCTALSWGRLRRVDVLPEPLSNHVIRLHFKYRNIKPFYGLKVSTKPLLEWHAFATVPDDDAKGKPDGFSIVISNAGDWTNDVIQNPPKKLWIRGYPLHGLLYTSKLFRKIVVVATGSGIGPPLSLFYADFTPRRIFWSTPAPETTYGSKIIDMVKKADPDAWIWDTRKQGRPDMVAVTYKLVVESGAEAVFIISNPKLTRKVVYGMESRGIPAYGAIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS62</accession>
    <name>A0AA38MS62_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="7">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1091668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS62"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3723585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="327" mass="35682" checksum="5F03E006B33237DE" modified="2024-01-24" version="1">MPANELSANDLKLILDFTVNLARKAGQLILEGSEAIQLAGSNVDEKKNSVDLVTEYDVRVEELVKKEITATYPDFKFIGEESYAAGSRSPLTDDPTYCVDPIDGTTNFVHGFPWVCISLGLIYKKVPVLGVIYNPFLDLLYTGIKGEGSYLSKHGGSPMRLPLAKSLKPLATLNHALIAVEWGNDRTIDPLTKRSESFHKLAGDPDKGVEGGRMAHSLRSLGSSAMNFATVAQGGLDIYWEIGCWPWDVCAGMVIAQEAGGVVTGSHAYYEATKDSPSFGVLNEEILTGRKYLVIRAVGDSETENGRDTQKRIMGEFYNTVTDYNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSQ5</accession>
    <name>A0AA38MSQ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1084327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSQ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19101">
        <property type="entry name" value="AKR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="346" mass="38931" checksum="C14FF61D488E2BC2" modified="2024-01-24" version="1">MSRKTHTSRFASSDMESFQLGPSILPRMWSGLWQLSSNAWGTAPLPRIREAMTRYVDTGYTAFADHYGSAEIIFGQFRRSLPPDQPVFGATKWCVFTDIESSQELVEAAVKERMERMQMDRIDLLQFHWQNYSQKGYLSTLKILQGLKTDGWISALGLCNFDSIRTDEICTQLGPGVISSNQVQFSLIDTRPLHGMADVCEKHGIKLLCYGTLCGGFLSEVWLNKPMPDRYSNHLTPSQRKYLDIIVGVWGGWQLFQELLLVLYDIGNGHGLSISNIATRWVLDHPFVGAVIIGTRLGISEHLDENLRVNGFRLTESDKAALDVVLNRSNGCRIITSIGDCGAEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU45</accession>
    <name>A0AA38MU45_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1154308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU45"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="397" mass="44043" checksum="5E84375C6CCB670E" modified="2024-01-24" version="1">MIPAGASLIAYLVASSAILLTYFFFFPPNSSSKYQYTTTPTYLRPTFSVLVLCHTLFILYELLLDPPTNLFTALDVPLSYPADSIRSLLLMFSDDPASGLPSGIERVLTRLESATMRLLYVRFGHEAIATCEYCTSWDDFSLYVLPSALWDYLREAMIIGALTLTGTRLTQYRSLSIGALVAAAMFEAYLTLTAKISIPNEFESSSNVWRRIEGLYGGYGVVMWHDALLLARRALFLVLPIVVHFVLKPSPIPLSAITLSNSLPQGDTTRIPPEALALHTLQALTTKLQLLRLTRGAIPRNPTLRAASESYWMMERQEGDWIRSDENVQDMARRLGSGFDEAKGRDTEEAKDNFSDGPLLKQAKAAVQNLIDKGYVPSPFWRPSPPSPQVVSAVGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU75</accession>
    <name>A0AA38MU75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1162344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000151">
        <property type="protein sequence ID" value="KAJ3709933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3709933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37335" checksum="D9ED413F2E42A458" modified="2024-01-24" version="1">MSPTPSRSSSPSDDEEKAEELRLQKKKEERIRREAARKAEEEEEAAAEARLAEIRRKKEEKKKREAEERKKKEEEERKKREEEEERLKEEERRRKDEERLAKEKEEKEEKNRAKSVGALVQASIARRGKKNHPIDVDSPTVVGKKRKRTRMIASNGDPESDDPNPGDDGEDSDTESDEYKDQKDEDEEEPEKTPTPTPTLTPRKTSKCDRCTSKDIACSMIGNGSASCIACRKARVKCSLVGNERRIRRSKRLRREDSVVASSSNERIDALEESNRELSRRLSLMEDMVRFIVQTIRPIDANEETEEDRVKRTGDVKGKGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUK5</accession>
    <name>A0AA38MUK5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1161497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000110">
        <property type="protein sequence ID" value="KAJ3712335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUK5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3712335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="339" mass="37182" checksum="603EDEC218693FB2" modified="2024-01-24" version="1">MALSFAQAELIGLILHSCLFGLYLFLFFSSLPFDIDIEFNIRPKAYNTVLLISNALLFMLISAHWVVQIIRSQRAFIYSDGEAGDAASAYYAFPADYMNLLKESLYLAQTFIGDCTMIYRLWIVYNKKAYVTVVPALMMAVYATSAIAVVIALGKTTVGENIFISTAGVWAIMVFSTTVATNVLTTSLITARIWSIKRKVRGVALQSGGLASVLHIIIESAALYTTTALLTLIGYSTEQAWQFITIDMISPIIGISFTLISVRVSRSTPSQGIYSTHDTPSSNVVRIRGVESRREAIGLDTISVNVTQHVSKHTDLEDGLNGSGVGDESLSDSDQKRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUT0</accession>
    <name>A0AA38MUT0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_888386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000094">
        <property type="protein sequence ID" value="KAJ3713995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUT0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3713995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="139" mass="14674" checksum="6C6DF4CD5A05CC7D" modified="2024-01-24" version="1">MADLSDFIALIATIAIFAGIIYIIYTVTGTVSEGVKSTKDRLKEKGYEISDQGMSVKTSKRMNREDYVDATQRGLIRAMGASSFGSNINGTAQTPASTSPSATSANLSAPTLKHQSSSSSTKSASSGQKISLFGKKKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVK6</accession>
    <name>A0AA38MVK6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_894844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000099">
        <property type="protein sequence ID" value="KAJ3713470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVK6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="626" mass="66844" checksum="D60D337F2D44A248" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVW3</accession>
    <name>A0AA38MVW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_840205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000082">
        <property type="protein sequence ID" value="KAJ3715900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVW3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042859">
        <property type="entry name" value="NOL11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633:SF2">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3715900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="785" mass="86536" checksum="2AB7121DB23D10B5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW00</accession>
    <name>A0AA38MW00_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_961402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000079">
        <property type="protein sequence ID" value="KAJ3716260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW00"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3716260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="222" mass="25472" checksum="67CE477A7FD078AF" modified="2024-01-24" version="1" fragment="single">ASTCTDPSVRKEWRTLTKDERAEWIGAVKCLSELPHDSALTPFVHPDDIAPLNTSSSYYDDIVYMHMDLNHLVAFPIHFTGLFLPFHRWYVQVYEYALKEKCGFKGASPYWNWAEGEARIDAPNFFNSTFFQDFDPISGLGGWGNLLDDAQVPNGAFSDFKLSYPSYHTLRRNFTLQPYIGQDPTLFTEPYLYANTSFTQSEVDKMVSGFVGDYKGFQTYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWQ6</accession>
    <name>A0AA38MWQ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bestrophin, RFP-TM, chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_650544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWQ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3723452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="428" mass="47993" checksum="8043F2FCF48C5C05" modified="2024-01-24" version="1">MSDTGTKGSAKRTLTSVFPSLRPKRKHLRKYSWLPDVFRIKGSIIRRIFWPVTTNTLFATIIAYAWHNGRRIALTNSIVPLLSVVVGLILVFRNGSSYDRFWEGRKSFATVTSNVRNLSRQIWVNVALPPSDQEDTPSKKGKAPILTASQLHRVKSEALHLCLAFPFAVKHYLRGEDGLNWSDYHDVLPKNFARFDEVGYQKSKTDLTTSYNSISTKSSGRSSPDLGRGDATKRVRPKRSKQNLPSQSTPLLSGAVTHRTVEFRPFADDTSLPLPLIIAHEISRLLFYFRREGLLETVGPAGTNAMNALVQSMVDNMTAMERIANTPIPISYGIHLKQCVTLYLFALPLTLVNDLGWMTIPIVTVVAFTFMGIEGIADEIEMPFGHDPSDLPLDRYCLDLKEEVLYIIERLPESGEGIYGYDDGEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWR4</accession>
    <name>A0AA38MWR4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_674249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWR4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041282350" evidence="2">
        <location>
            <begin position="22"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="577" mass="63632" checksum="82EE3AD264E6E765" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX01</accession>
    <name>A0AA38MX01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1004534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX01"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3721339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="264" mass="30806" checksum="90BB06CE34AB4DDD" modified="2024-01-24" version="1">MKSDDIARLDPGRMLNDSLIEFGLRFWHHGLTISHPRLAEDVFVFNPFFYSVLEANSPEEAYKRVKTWTLRGKIEVDIFSKRYLVLPIHDRSQHHWYLAIVYRPEFVLPYYQASLTSPNLHAYGESESMPVEVNVKDSDVAPRTRVFILDSLGGSHPQVTSRLSAYLRLEADAKHQLRPTADAVECYVKVPLQPNQTDCGMYLLYFAEIFVEYLESSMSAPESQEDLENLWDICRLQHYHRLKHYRMNMTQNLLKTKYSNLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX38</accession>
    <name>A0AA38MX38_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Utp21 specific WD40 associated putative domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_697766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX38"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="4">
        <location>
            <begin position="66"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="618"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="3">
        <location>
            <begin position="748"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="949" mass="105018" checksum="D91B18051697ABEC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX47</accession>
    <name>A0AA38MX47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1090019</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX47"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3724959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="204" mass="22954" checksum="68F6DE88E61A9B52" modified="2024-01-24" version="1">MASNITFHDGTVSSEERFHSIQQKGATIWLTGLSASGKSTIACALEQHLLHLHKFTYRLDGDNIRFGLNKDLGFDEKSRNENIRRIGEVSRLFADACCLTITAFISPYRVDREFARQIHEKSGLPFVEVFVDAPLSVVEQRDPKGLYKKARAGEIKDFTGISAPYEVPEKPEIHLKTAETDVAESVRIITQYLVSHGYIPETTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXF1</accession>
    <name>A0AA38MXF1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_725790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXF1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1026" mass="115841" checksum="56B452719642B17E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYD4</accession>
    <name>A0AA38MYD4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1122595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYD4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="128"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3727249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="235" mass="26430" checksum="699952CEB5D9747F" modified="2024-01-24" version="1">MSNYSAGIKSSTTRSDQRADQRLLAKMSPLDRPYPLNAVCPRPIPNSYWATPLLLACEYPWSPKNPYKPKLDALLKAGVRTFIDLTECGELKPYSNILCGRATLLGIDPSTIEYYNFPIRDRSLPQSVEYMNSVLDVLRDNQVRGRISAVHCRGGIGRTGMVIGCWLVQSGIAKDGDEALHIIAKEWSTVEKCKRFPHSPETGPQFEFVQRWIRRDRCGKLDLGDVSLSQAQIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYG3</accession>
    <name>A0AA38MYG3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1041170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYG3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="48"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3727369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="543" mass="60364" checksum="C00FB32FD1A004EA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYK5</accession>
    <name>A0AA38MYK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1081310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYK5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3731070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="443" mass="48165" checksum="CE4A57AAEEC97FA8" modified="2024-01-24" version="1">MLQDFRSPFDATVVKLLKKAGAQISGKTNCDEFGMGSLNIHSLHGPVINPFRVDSRRAAGGSSGGSSAAVAAGLCDAALGTDTGGSIRLPASYCGVVGLKPSYGLVSRYGVVSYADSLDTVGVLAQDVERVEKVFECINKRDCNDPTSVDERLREKAHLLATKSIQRWSGESLKGLRIGIPQEYFPSELTSSSYHILASIRHLLSQLHSLGASIVPVSLPSTAYALSAYYVIASAEGSSCLSRYDGIQYGLRVPPSPESNFTSTSRTYSPSRSQGFGREVRKRILLGTYALSADAFDNYFLQAQRVRKMVRDDFDHVFSIPNVLYSKLSFEEKDANDHGEDGVDILIHPSAIRTAPRLDDVLDVSCDRDTLQDYVQDVLTVPASLSGLPAMSVPMRPDAGLNQPRDNQQSDENWPIGVSIVGQWGTDELVLKVGRVIERLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ39</accession>
    <name>A0AA38MZ39_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_491345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ39"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3728990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="635" mass="69475" checksum="9E19596623B11164" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N026</accession>
    <name>A0AA38N026_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1155435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N026"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="69321" checksum="299A9999BAE86EC4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N038</accession>
    <name>A0AA38N038_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1081638</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000066">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="868"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="979"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="79"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="423"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="754"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3731133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1324" mass="144317" checksum="E13BED451EB1EC8F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N070</accession>
    <name>A0AA38N070_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_998794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N070"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3731687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="629" mass="69428" checksum="144CCE1D75006B26" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0X4</accession>
    <name>A0AA38N0X4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_995511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0X4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041236580" evidence="1">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="255" mass="27425" checksum="FEE22E3A8536A6DD" modified="2024-01-24" version="1">MFLTFLLLILNALQTAQAAFIPVSRSSSSSSSNSSEITLSQLDAIINGTTCPLKGSESLDECRTAAQALPFVNKGFSDYNITSVGEKAALLSLMSFESGGFQFNINHFPGNPGQGTRNLMEFPAVYQYALSTPFLSNQTLALLPNLKKHKGRTSYASLSSLPNTLSNQTKNAIRAVVLGDGLSFASAMWFYTQSGATQIGQPGQGCTQIAGLVQGLQAQTEAGWEHYITDCVGTTVTDERREDYLRTLKILNGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1A0</accession>
    <name>A0AA38N1A0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin associated protein KTI12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1068111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1A0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="296" mass="32981" checksum="A1BC010D533A28E2" modified="2024-01-24" version="1">MSLITITGYPASGKSSRASQLQAFLQEKVDASKEVILLSEKSHSLDIKRSSYDNSAAEKLARGALLTAIIRLLSPNTILIIDAPNYIKGFRYQIYCAAREVKVRVVTVYVLAPQEQCRQWNKLREGDDRYSDETLENLFLRYEEPSSMVRWDSPLFTLLWSDESIPQTTLDAIWGAVEKGKVSNPNSGTVATVKAPTDALATLERTTLLIMQQIMSAQDGSGGVMTLSPAPGFSPLELTIPPRNVTLPELSRLKRQFVTVQKKVITLGTIERGSVDWSEKGVGERFVVFLEEQLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1B3</accession>
    <name>A0AA38N1B3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1179605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1B3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3732677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="506" mass="57032" checksum="6C48829B2AD327BF" modified="2024-01-24" version="1">MASSSTWLALGIALVALYAVRCVADDRLTKSKYKDVAFVGPTGTFGTVIGFFQLLLGFRDFIQEGFEQHYGKLFAIPTLFQMTFVVSGHELIEDVRKASDDQLSLYGSIKEGMQTDYTMEPHILENPYHFKFVHLALTSNLGGRFPELREEVITAFSELVPPTDSWTSFPAWLTGKHVVLRVINRLFVGPSLCNNAAYNEINDIYSDALVKTALIMGFTPGPSNRDLVSIVSKLLDSYIPKTLRQAMEHIGPLIEERLDQERMFGKDWPGKSNDLLTWLMEKAPESEKSLKAITIRLLATVFAAYRPASMALTQALFDLATFSSYIPELRDEIEPIVKEEGITKESINKMYKLDSFIKESLRLRAAGKSSMPRKVLKDFTFSDGTTVLAGNTIIAPGYAIHHDARHYPNPNEFDGLRFARLREKHDDPVRYQIISVGPTFMMFGNGRHACPGRFLVSALLKTMIVHVLMTYDIKLEQDGVRPVDKWYTFTPAPNQTAGLMFRKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2P8</accession>
    <name>A0AA38N2P8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1066063</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2P8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3734072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="505" mass="56251" checksum="A2CB64FD689DF1E7" modified="2024-01-24" version="1">MQPILKIFVPVLASIVAYYLFRTIRWGLSRIPSPLSLPGPPNPGWFFGHQKEIWSKSTPLGEPTLMDEWHEMYGPTFKAGGFFGGYRIYSMDIKVVQHIMRNDDIYLKPPVMRNLLNMILGEGTGVIVAEGAQHRLQMRDIWKAQIANEGVGEIDPVEWLSKVTVDIIGLTGFNYHLNALNDGQTNALNEAFKTMFHSSGWDSPWMPLIAALPKSIQSIIKTLALACGVDTAMKSSVDCIQRSCRQLLIENKAQLVATGEKDIGSGSRNLLSLLLKSNMSPDTPAHARMSDADVMAQIPTFLIAGHDTTSLATNWALLELSLHQDIQAKLQEELLSVPTATPSMDELNGLPLLDGFVRETLRLHSPITTLGRIAVQDDIIPLAHPFTDSDGTVHDKLPVRKGQLIHLTLHQVNTDKSLPDRWLNLPDSARTIPGAYSNTLSFWGGSHGCMGWRFTSIEMKVLIFVLLRSFHFELAVQKDELMVLKMASIWQRPSLPLVVKLLKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N390</accession>
    <name>A0AA38N390_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1152430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N390"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29181" checksum="8218012290D9F999" modified="2024-01-24" version="1">MQANEFLLEAALTESFTPPPSRRQSKITPAPASSSLRTNSDPTPAEAFGDSEPTTTDAWKNEYEEQVKAWRLQSAEAREKAEKERAKWETLREVEKTSGTPPPLPPSYELLSQKPQLPTSDSPSPADARDLVTGETPKATSHSRQFTGEDSQKWENLPSEVTSSLPSMSFPEDSGHEESRAAPSRSPPTAPASATLSVFDASLSTTTRFRAFASALAINLLLPFVNGVMLGFGEIFAKNVILGWFGWKTDVPGSTAASLGLRKTRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3J3</accession>
    <name>A0AA38N3J3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase component PIG-T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1167880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3J3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="544" mass="61329" checksum="C0B745F15209E24D" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3V1</accession>
    <name>A0AA38N3V1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_62544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3V1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="135" mass="14989" checksum="63EFB7BAFC75F403" modified="2024-01-24" version="1">MGKDGKQVSIEELMKELTSYDGVGPKTASCVLMFCLGRDSFAVDTHIFRLSKLLGWVPSSADRILTQAHLDRMLPAKLKYGLHVLMIQHGRTCKGCKKSGSSTPCILKDFVKETMSSGPALNKSEYRYQFSKTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3W4</accession>
    <name>A0AA38N3W4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1199044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3W4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="617" mass="69087" checksum="545891B407C4BD2A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4M8</accession>
    <name>A0AA38N4M8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1017420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4M8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041351659" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3736966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="191" mass="20220" checksum="F754D11DE240B250" modified="2024-01-24" version="1">MRFFTAFTLTALFAVVSAHFQLQFPPPRGAFVEDQEPNFCDGYDSVASNRTSFPLNNGIISLNSEHPQWTAAVFITNVSNPTSFDNFTQITPFFQENIEGSFCMAFDLSQTNATGLTNGENVTIQFLFDGGDGQLFQCADLTLDTSANVSSQSCTNATSSSSSGAIGTPVPAVGSLLGLTAGLVGVAFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4P1</accession>
    <name>A0AA38N4P1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1017721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4P1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="534" mass="59745" checksum="9E61DBBF9DD295B4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4Y2</accession>
    <name>A0AA38N4Y2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1045244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4Y2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24684" checksum="108A0D56D9A1A137" modified="2024-01-24" version="1">MKPEHKPLNAYRKISLICVFLLLAAFVLLLLVGISLPIVHPVYIIRVYATPTGPATSLGTELRFGVWGVCAYSQLNPPSVLNDDGLCYGPRLGYQDVIPSVILAQIGLSQGLIDAALKGLLVVLIIHIVAAGFSLAGLFTSLFLASHSMTILSLLLSVITAILSTVVFVIDIVVAAVARVKIPEFSNDLSVGVGNAVWMVLGALVASWLGVIFLSARACFCCGVRRRDHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5B4</accession>
    <name>A0AA38N5B4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1050462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5B4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="136" mass="14387" checksum="875229522D2F1BA9" modified="2024-01-24" version="1">MANKKSGNTAKGKSDETKGKSGSASAGDEKSSKVKGGLKAATAVNVRHILCEKHSKATEALQKIQEGQSFNKVAQEYSEDKAKAGGSLGWMVRGSMVGAFQDAAFSLTPSSIDKPIISPLVKTNFGYHIIMVEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J296</accession>
    <name>A0AA38J296_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1108574</name>
        <name evidence="2" type="ORF">DFJ43DRAFT_138036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000131">
        <property type="protein sequence ID" value="KAJ3710878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000131">
        <property type="protein sequence ID" value="KAJ3710881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J296"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="91" mass="10219" checksum="CBADEED048BC933B" modified="2024-01-24" version="1">MSIVIKWTVTALQDIAQFVAADFGNVDPKEYHEAKVLEYLYTHQLPVGTNIARIRRGAHKGGSDPRRPDHITLSLQRGGHKLQTAHVYTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J367</accession>
    <name>A0AA38J367_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_836016</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000080">
        <property type="protein sequence ID" value="KAJ3716249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J367"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="174"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="550"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3716249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="652" mass="71912" checksum="15A52110C2F852A2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3J8</accession>
    <name>A0AA38J3J8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1043100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000073">
        <property type="protein sequence ID" value="KAJ3717572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3J8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="173"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3717572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="344" mass="38441" checksum="F10F3EB280922867" modified="2024-01-24" version="1">MSASAGATGTAIMDVSLTTGAILVGSLFSFFTMGVVAVCLWIYFTNYPKDPIYFKLLVTFMAILSILDTVTTGCWAYLWAVTHWGDPTIFAYLPGVFVIETFCFGTACLTNQCFFAWRLWTITKRKNWYLPLFIISNGLIQEEILKSPRLAVVFWLMNLFRTDPLLVDLGAAFLGDASVTVGMVYYLRIKSSREMVVNANSRSVLNGIIVRTLQCNALALLSQVAMFVMFFLKSNPHVGAYFFFNDFLVVKIYAFSLLLTLNARKTMASKFDSSRGGGTSDNIALSNVQSAIASRNRTRVQLPTEPGVVSIQVHQQVDVDETWKQDTATSQYSSERKVDYEDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J583</accession>
    <name>A0AA38J583_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1108725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000134">
        <property type="protein sequence ID" value="KAJ3710629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J583"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041357376" evidence="1">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="183" mass="19782" checksum="E04061809B738C46" modified="2024-01-24" version="1">MHRSWPLLSLAFIVLISLSSVCTIPVETNLNPQLHSRGLSLNGIDTSSLSSSAIKIEWISSQNKLASPTPEQLVSITTSEKLAKTKMHTLMKNAQDVLGLILGESSTIQYGSNPSFASALDYAYKLVKFQITVTGGTKCEGKVLTGLLYLGSKPEEAPYLKRGQIKCGVEQVFPMPEPHHGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5R2</accession>
    <name>A0AA38J5R2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1158643</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000003">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="692"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="785"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="877"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="969"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1061"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1153"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1246"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="1320"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1720"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3721300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1862" mass="200404" checksum="6835D9F640C6C577" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5R7</accession>
    <name>A0AA38J5R7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1089123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5R7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000039">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF874">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="218"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3725564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="373" mass="41906" checksum="1DDF6FA4B312CDF0" modified="2024-01-24" version="1">MDLPIIDLDLFLSQPQDSPAVQDECKKAADALITFGALILRDSRVSESDNSIFLDLLEDYFAQPPSDIKKDERPELSYQVGVTLENTEKPKCAADEPCLRIIERLELSERPLDISAHSPDPKCRFFWKMGEKPTYETQFPGLNAPNVVPQAEHIKARWTPIMESWGESMKQAVESLADMACIGLGLPSNLFRDAGRYGPHLLAPTASDLVKYGQKDTILAGFHTDLNFLTIHGRSRYPGLNIWARNTGKRLPVKIPPGNHLLVQAGRQLEHLSGGLIKAGYHEVVVNDQTLQVIERRNVENPDRPLIRISSTFFWHLSSDYDLIPIPSLVERAEALDVAQIQLRGYLTDKPVYQPMKVGQQVQNELKHIALMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J603</accession>
    <name>A0AA38J603_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1109442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000157">
        <property type="protein sequence ID" value="KAJ3709805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J603"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="80"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3709805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="231" mass="25265" checksum="43C8BF8595563185" modified="2024-01-24" version="1">MVEEEYRPSIILKVDSGFTAVFVQSFLAHRVWQLSNGNMWISIPALLLVAAEFGILIRVHTFVELAEILKGLSITVNVLAAVGDTYIAGLLTLLLHTSRTGLRRSDSIINKLIICSINTGALTSLCAIASMLSILLAPETFIYISFFFCMGRLYANSLLATLNVRSLIRKEGSSNVQASGDTGSIPLGAYNTSVFNPPSAISVKIDTRREYVSDEEEQKHSESVRSQMDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6H8</accession>
    <name>A0AA38J6H8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bestrophin, RFP-TM, chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1167604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000115">
        <property type="protein sequence ID" value="KAJ3711846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6H8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3711846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="356" mass="39501" checksum="FCFF43F2D5F14642" modified="2024-01-24" version="1">MIIVLHRSSYDRFWEGRKSFATVTSNVRNLSRQIWVNVALPPSDQEDTLSKKGKAPILTASQLHRVKAEALHLCLAFPFAVKHYLRGEDGLNWSDYHDVLPKNFARFDEVGYQKSKTNLTTSYNSISTKSSGRSSPDLGRGDATKRVRPKRSKQNLPSQSTPLLSGAVTHRTVEFRPFADDTSLPLPLIIAHEISRLLFYFRREGLLETVGPAGTNAMNALVQSMVDNMTAMERIANTPIPISYGIHLKQCVTLYLFALPLTLVNDLGWMTIPIVTVVAFTFMGIEGIADEIEMPFGHDPSDLPLDANGDETAPVCPSYGLEPFILASLTKLSILHLKRSATLDLDTGAAVRQFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J838</accession>
    <name>A0AA38J838_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1160097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J838"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3716321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="509" mass="55620" checksum="CF0A2FFDF0E7E4AE" modified="2024-01-24" version="1">MHLHEIIFCATASPSTASGSGSVTLHDINTGASLASFKQTNAAPHCTTFSNSKNAQGGFFLAAQPDKSLLHAYNFQKVDQISLKIVLPEKLTCVALDPSGDLFAGGTAQGRIYLWEVSSGILFNSWDAHYRQINVLRFTPDGAALLSGSDDSGINVWSVSRLLDEESQNTLALPYFTLTDHTLPVTDIFCGMGSFPECRVLSSSIDHSVKLWDLSSRSLLTTFMFPEAISYLACEPTERLFFAASTSSEGAIYQMNLFRQPEDKGAIARAIGGGGVNDIIRITDAGSHNKRLITVGQPITCLSLSLTSNLIVGTSSGLIHIYDTPTHQLLRTISTHKGLSISYLATLLKPIDLTGHVSFNFNSSVTTVDTIPVKPVVPFQRMRDAKAREIHEVSMMLPPQRDNYEDESEFYSKESLLHDHAYFTAPSSSGTRPGDISVPHSRVSELEAEVVLLRGQLGQAKGVNDLMWETIVQKVVHTHTKSTSNVNSESTDERRTKRGRIDSDLDVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8X2</accession>
    <name>A0AA38J8X2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="14" type="ORF">DFJ43DRAFT_1079526</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8X2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="13">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3731561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="442" mass="49001" checksum="45C5DF06D9A30F7A" modified="2024-01-24" version="1">MSSILSERQQDDLHKAMLDYLHTNGFHKTYDQFKAELPNQADFQPDPSAKTSGLLAKKWTSVIRMQKKIMELETRLAQALEDNSHMALPNGTGGKQSNTDWLPTASSAKHTLTGHRGTVNAAAFHPIYSVVATASDDFTVKVWDWDSGELERTLKSHTKRVSDCQFNSTGTTLVTCGYDLFIKLWNVENDYQNFATLRGHEHSISSARFLPGDDKIVSSSRDHTLRIWDIASTHCIKVINPHDAWIRCAVPSEDGRLIITASGDHTSKVVELSSGDVKAEFRGHENDVEAAEFCPPHAVAAIRELVAVKAPQGAQALANHGPVFAITASRDKTIKIWDVNSGQCLHTLHGHDDWVHAIVFHPNGQYMLTAADDHTIRIWDLKTGRCTRKIEAHVQFVTSMSWGRQVVGTQSSDKDPSTGPRLVNVLATTGSDQSVKIWVPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J973</accession>
    <name>A0AA38J973_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine incorporator/TMS membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1134406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J973"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3717650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="500" mass="54905" checksum="B5B7F9E1B421F5CC" modified="2024-01-24" version="1">MGLLFSIPLAGVFGTVGSSCLAGLAFCFTSTAASMFCKSCNCNSSIATRVGFAIIFCINCMLAWLMRTDFAIKQIEKWSYDYIKMDCAGDKCYGVLAVHRICFALTLFHAILSLALIGVKDTKDKRAAIQNGWWGPKILLWLVLLVISWFIPNPFFMFWGNYVTLIGATLFILLGLVLLVDFAHSWSETCLDNWENASNGSNLWQWILIGSTGLMYIFTITLTGILYGFFAGSGCTLNRFFISFNLALCIIITIMCVHPLVQEYNPRSGLAQSGMVAAYCTYLIVSAISNHAHENSTCNPLRNGSTTATGTRTTTVILGGLFTFLAIAYSTTRAATNSRALVGKRKKVGAVHLDGPDALDGHAEMGVVNTQPGRTESPRYQALLAAVEAGAIPESALHEEEDSEDDDEDVGDNRDDERSGTRYNYSWFHVIFVMAAMYVAALLTDANIVSKKPINGTTDPNSDVYIGQSEVAMWMRVVSSWICILLYTWSLIAPVIMPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J986</accession>
    <name>A0AA38J986_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1005529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J986"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051667">
        <property type="entry name" value="Archaeal_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096">
        <property type="entry name" value="YALI0E33429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3719125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="81801" checksum="657C72D47BC9DB0F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9T6</accession>
    <name>A0AA38J9T6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-induced vulval development antagonist-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1081866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9T6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="322"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3730899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="435" mass="50305" checksum="5942D4B7C62AD881" modified="2024-01-24" version="1">MATVHPSRLGLVPQDSSTHRRSPSPRPSRRSSSPKRSSKTDSRNYRARHDDDRDRDRYSGRESEYNRGRSHGQSKDRDRAENRRASPQYEDYRRPSPPRDDPTPQRQGENMYPNRKDRDLDRDPPPHNAYSSSRSGGGADFLESRRLQRETLSVDIWPPSPKAPARQLSPKRSSKKSKRQLSISSDTDSEEEGRRRRERKERRRRKEQRKEEKREKKRRRSRSRRRSEDEDYQSRKKSYSKSKSPDRRASSARRTRSPLPNDDDDEWVVKGTGSEIMLPPAAPLSENAPRTNPIPDFGSDDDDESVGPQLAARANVKRVDERSYGGALLRGEGSAMAAFLQEGTENRIPRRGEIGLTSNEIAQYEDVGYVMSGSRHRRMNAVRIRKENQVISAEEKRGILKLQKEERERRETILREEFSELVHESLKGAERPKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9Y5</accession>
    <name>A0AA38J9Y5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dipeptidyl-peptidase V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1099964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9Y5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="10">
        <location>
            <begin position="150"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="472"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3717221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="710" mass="77567" checksum="A35B27CE4B1D6E9C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAC5</accession>
    <name>A0AA38JAC5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_323634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAC5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="315" mass="35036" checksum="0D0ACC9FCC9D3378" modified="2024-01-24" version="1">MTASQLPSSDLVYDTTSVYTKIFIGLQLAGLIGNIVTLIIAYFSPVTRQATWYNCIIMWCIYSIAFLLLFFSGHYHDPSPPFDLCLIQSALIHAASPSATAATLALVIQLYFSVYSALNLHPIPYQSLWLKIILAFPYATGSILVALFLVLSLIDPSTTTFNITAYCAVNQIIPGRITAGLTIALVIPMMIIDGLIYARLRKHWSEFRASQLGRYTSMIIRASLFSICAFVALCAGFGFFLVVFAQDPTEPIDQVVPRLLLAYNILNIFLSIFPVAVMLIFGTHEDILRRLFFCERHEMNSVSEHAVPIKDTNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAF6</accession>
    <name>A0AA38JAF6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1224811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAF6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="246" mass="28032" checksum="FCD1CD07223E4AFD" modified="2024-01-24" version="1">MRLRPSITSHCILSVYLLSAAFLSIVVVANPIPIPRRTTDGKDIRIRLAWRILGVRDFEHVSNGFEAVDRFTLFMTGTGFSAGFEFQDSKDPSHARLVQVALPLAPSQTITEAVLKDFATDGKRLMARFIDGDFFFGNYAVIRNVDRLRTETNTLLKKKKVEEYKDFTIGDPEFQDEIDIIRDDLDWINTVLLYLTLINQPERKVPVLAPQDLVGWTVIFEEMTKETQTHRKVTRICSAEIAAEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAI7</accession>
    <name>A0AA38JAI7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1040183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAI7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="112" mass="12625" checksum="DD7EC41134CF49B6" modified="2024-01-24" version="1">MTSTKIEIFWAMTGSNAQLSRPCNATIVKTVRKALSNRGSWNCPRGIPPVWVIACGPRGNHPHYTIRLFYPGSPFAAFTIHQRRSRHEFFASASHSFTFTAYNPMLIAEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAQ3</accession>
    <name>A0AA38JAQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_999128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23197" checksum="B4298C0A922A7AEF" modified="2024-01-24" version="1" fragment="single">MGISHHPQNSENTFPTSPSAATNCSGLPSGAKKARSNSKLSDPSTLANLSASRTARESRFTLYEAEIRRRAWWTIMYYDLFVSDIMNQPPLIADNSFNTKRPVANVDEKAFGPTSIRIPPPADGGEDGTGYSKDGMRYFEIRSRLTMLVRNIKRRMNTPEFGHAQQVRTSYYGTSPNGHCYSIDQAASMEAEVRAWLNDLPSYYQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAU6</accession>
    <name>A0AA38JAU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_372512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAU6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="293" mass="32269" checksum="0FF1AB1A39EDED6A" modified="2024-01-24" version="1">MEHLFSLGLESADTNIKPDTQFIPKSRIQEHSISEKSDSMLGLSEEQKIDALPTKPVSKIHSKDSPKIHVEQLISRQSEEKPQDTMASNESDASSQSLSTASEHGAGKELMSGLMGVFHEVQHHLDTTDVRKLVGVLDSHRVSQPVQHPPPPQSQFPGLMNKLGEMFEGDEAQKRRQEEQAEKHRLEVEVEKAKHHHLPADMFEKLGLGSRSDVESSPASQSESFMEKLSLKVHSAASGNTVVALKDQSLAGRLDSVMHHKKDGSSSRLGGGYLTQSRVPWAAGVQLRGKKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB29</accession>
    <name>A0AA38JB29_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_739937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB29"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="349"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3719574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="909" mass="95623" checksum="F62660BDF2F92C0A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB77</accession>
    <name>A0AA38JB77_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_358285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB77"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3731724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="230" mass="26762" checksum="3315808621AF9328" modified="2024-01-24" version="1">MSGLPDLRNQFFFPRFSSLPLDAGFLTLYDDSDDDFIAFDKSKPRFQNRSPRKHWCIFAEIVQENRWPIRPVYQVKDLSGRQSLVSFNFDDRSLFADVARKCKVGYTLCIMYAERHQFADGNEGVRVEQPDAVKVLPVSLRELLATSDVFRASIKANHASTDTAACSNCYKPAAHRCSRCSLSEYCSKECQTQHWAKKHKKDCQVLRQLKLWNAFDWHRYDVRRGMNDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBK6</accession>
    <name>A0AA38JBK6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_779356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBK6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3718108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23413" checksum="FB01C4DED842AA63" modified="2024-01-24" version="1">MSGIAFVTGASQGIGKGIATRLASDGFEIAINDIAAKSSALEAVKKEIQELTGKHALICVGDVSVEENVKAMIDEVVKTFGSLDVMVANAGVCPCGPLNDGKKIYLRITHGLRDFLSVTLDEWERAFAINVRGTFLCYKYASLQMIAQGKGGRLIGASSGAGKQGQQMMGLYASTKFAIRGLTQSAAMEYGKHQITVNAYCPGPIDTEMGRPCVIATALATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC47</accession>
    <name>A0AA38JC47_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1158646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC47"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3721303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="162" mass="16613" checksum="DFC47C0465151951" modified="2024-01-24" version="1">MNSLSLISPWTMRLAFIIEPALRVIQQNVLSHLDHRLLRVLRFCHPCCRHPGGVKPTTTLPPVTTTVTVTAPATTTTITSGSCTTGPIQCCDSTESAGSAAGSLLLGLLGVVLQDLSVLLGIGCSPITVIGASGSSCSAQTVCCEDNAVGGLISIGCIPITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCU5</accession>
    <name>A0AA38JCU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Creatinase/Prolidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1161752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000118">
        <property type="protein sequence ID" value="KAJ3711473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCU5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="6">
        <location>
            <begin position="277"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="5">
        <location>
            <begin position="602"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3711473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="688" mass="77362" checksum="40C2BA0E4E4406CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD63</accession>
    <name>A0AA38JD63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TRAPP II complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1070512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD63"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="366"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="569"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="925"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129728" checksum="EF1A7B1EB7E334F1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD94</accession>
    <name>A0AA38JD94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1083449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD94"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="324" mass="36636" checksum="4F0DD0DE10AE7E0E" modified="2024-01-24" version="1">MPSPHASLSSPLLYPSLDYSPEDPPDSICTSKGSRSNRMAVDVAVVRNDLSRTDANSNVLAVSSSLNLRGSRFQSLSWRLGHFDYLLDALNELRSEFFTTSQHLLPDNEFRLSASRIMDLIQIAKDTLEEAGVDLWPHSLCVIGLRRHKKAYFVLLKLLRSRADSLDDQLQARSRRFTCRLSTNFSIRVNPAYDLYLPPRPRNSRDQNSNRQRLQQNKLCRNMPPPDAFPPSDFLPVYSQSFLDPQRCRRRMRFELSSDEWESLGLELPSRSAAPSIAVHNTHSSLGSRRPGSFGTMKRRFGIFCMGKSGAMASNMSRVPVSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDG5</accession>
    <name>A0AA38JDG5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000099">
        <property type="protein sequence ID" value="KAJ3713474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDG5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="924" mass="104306" checksum="B157DFC02BC228AF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE25</accession>
    <name>A0AA38JE25_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1102008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000084">
        <property type="protein sequence ID" value="KAJ3715568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE25"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="261" mass="29190" checksum="6A9C17A387F4B7C6" modified="2024-01-24" version="1">MGDTAPESTLPYPPIHQDKKFVVLSDWDGTITTYDSNDYMTDNLGFGRDKRRDLNIEVLHEKTTFRDAFREMLASVVANGHSFEECKEILRKNIKLDPGFNDFYAWCKANDIPVIIVSSGMTPTIRAVLTNLVGEESANEIEIISNDVDLKPDGTWGIKFRHPTSGFGHDKSQAILPYRNLENPPTLFFFGDGVSDMSAAKHADVLFVKEKEYGENDLAAYCTRLGIKHILFTDFSNALPVLQSVVRGEKTVQEALSIGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE42</accession>
    <name>A0AA38JE42_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_967176</name>
        <name evidence="2" type="ORF">DFJ43DRAFT_977439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000192">
        <property type="protein sequence ID" value="KAJ3709408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE42"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3709408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8816" checksum="4CE6A2D5B7146180" modified="2024-01-24" version="1" fragment="single">VNLLTTYRQNGWTLAVDGIIYSHIKLSGYNGDEFLLWLRGLLAVMNPYPGPHSVLILDNCRIHHVEGVEEMCETRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEE7</accession>
    <name>A0AA38JEE7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1225980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEE7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="572" mass="64478" checksum="11062412D5638CA8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEH8</accession>
    <name>A0AA38JEH8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1165926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000108">
        <property type="protein sequence ID" value="KAJ3712544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEH8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="565" mass="61761" checksum="8CC035F09E9DC2FE" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF45</accession>
    <name>A0AA38JF45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_495801</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF45"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="316"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3729029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="716" mass="77716" checksum="8F7FE2FBDC04BCDF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF68</accession>
    <name>A0AA38JF68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1088552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF319">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="247"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3725652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="437" mass="46175" checksum="02DBA099CCBDAF1A" modified="2024-01-24" version="1">MSKQASFEKAHHAEAGSHDATDPSTDGSEKGLAVTPPRHPVGATKAWLTVLGCFFIQFCTVASVNSFGVFEDYYVSEFLPSSSASRVSWIIGLEILLQLGLGVIGGKLCDLGHTRAVFATGSIVYLVSFFMLSLAKEDQYYQVILAQGVGMGIGVGLCYVPALVTAALHFPGRQAIAMGIVISAGSFGGGIFSIMINQLIPKHGFPSAIRATAYLSLGLLAVGNLLITVPPRPPKAVAGETPLLYTPYLLTLFSGFLGQLGGLFPLFYIQLFADSHHMAEGFIFYSVAAMSFSTAFGRVVPSYFADRYGVVGTYIVCAIINAGCAFIMFGASHPAGLIVFCIFYGFFFGSSTSLFSPVITALMPSEADRGKVVGVAMAPVAISSLIGSPVGGAIIGSSLDWWKGIVWTGVLMGTSATIQVVAREIHNRNLRSRKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFK5</accession>
    <name>A0AA38JFK5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucanase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_858864</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000089">
        <property type="protein sequence ID" value="KAJ3714648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFK5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041245339" description="Glucanase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="482"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3714648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="518" mass="53900" checksum="AA6CC9BE657237DF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGJ3</accession>
    <name>A0AA38JGJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_456690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGJ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041451222" evidence="1">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="203" mass="21101" checksum="2F16C5712746EF22" modified="2024-01-24" version="1">MFLSVRLLAALLVAASSSTTFITAFPVHLTVRSSETTFAQNFTLAALNTTLPNANSTGAPLVIGAAGGIDGGSMEVTSTYASYPYNDFLSLGLVNGTLHAYSKQQSLHTSASVPLLHGSLDWFTSSIYSTDPSTAFTAVSGTGNFSVLAFNGTADLWYLCPSDMPGSPQNSVYHNTSTIPSQSGAPGASPVQCYSVILNMVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGM4</accession>
    <name>A0AA38JGM4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_993439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGM4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40475" checksum="C23F4542D27E0B59" modified="2024-01-24" version="1">MATKEATLPQENAEYRWHHNLEPALFTHSPDNAFPNHIGHFLHPTRVTLALKDPNRDEEFLWKSRDHRKNRHVKYTPNQDKSRHGRNFFVGIAHMVRLEYWNVSWWVAIAFTIGSVIWVVNGFYSFLPFVDTSFAQSIAGIGWTAWVGATVFELGSILGVLEAWNRGETANFGWGVRRALGQENASDSNGYPVNSSSEGKAGDLKHQRKWIWFSFDSKYWHELGFLAAFAQFWAATIFWISGFTALPSIQDAISTRTGVLDGVFWTPQVIGGMGFVISSSLLLLETQKKWYMPNPASLGWQVAIWNFIGAIGFTLCGALGYAAQTSTKAAYQSSLSTFWGGWAFLIGSILQWYESVNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGV6</accession>
    <name>A0AA38JGV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">X-box-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1056018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGV6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052470">
        <property type="entry name" value="ER_Stress-Reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542:SF1">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3735626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="326" mass="35514" checksum="6291D1B8C4838B0A" modified="2024-01-24" version="1">MPKAPTNKTSFVNPATLSLPESTFDDMSSSPSPEPQPGPSRKRPRTEQSSEDRKEARAHRNRIAAQNSRDRRKAQFSYLERRVAELEEENRQLRAGMGMSPVAPSSAPVLVPSVSVKSSADEARDLENEELKERIRTLEKGWDAVVKALAAQGLPTGIAPSSNTDSVSSTASAPAPTTTPLSPSPSSSTTFSSTSASTSPIPSTVALSSSPSVVSESNEAPQSTRHLARVATGRTPLPSLQRVNWPSMTHTATISQPPLLSRSLMTLKMHRQLTTLPWNPSSVRSSLTANLHPSRRRIQNLSRFPQRVIRLVVSLNRKRPPPSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH02</accession>
    <name>A0AA38JH02_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_524959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH02"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="448" mass="49622" checksum="F4CCF5EE36268D80" modified="2024-01-24" version="1">MTDSSTTTLKFIITGGGIAGLTCAYLLREIGHDVVVLEKSSRKEQVTTDHGGVRIPPNMMRLLQALPRTQELLEAKASKCAGILFHQCKEGEPAELVGKMDFAQEVMNDLGCDFYFIPHKDLHEHLYTLCIECGVNLIHEFEVVEVQTSKPPNGNGPRVMNRSGDFVTGDIIIGADGKNSVVRKILLTEEDETEEVDSNTSDSGKSSLSTIKAIVGATLSIPISLLKSDPELEPLLRGENHWMVYMGNGTSIAMARYGPDLYLLDLTYGQQPLPGDEDSEWLARGTPAQTVLDRAQEYDGRVQKLINLGKRSHWNIQTVHALPRYVSKFNQVVVVGDAAHSMYINGTHNTYQQIQQKRTRAMETSEMNTMLLLGIPPGIEREGRNSGFKLTLHLDGADDATLERVWAGYVAQFDYDARDAVDEWWMTWARPGNRDSSIIGGVSVISTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH56</accession>
    <name>A0AA38JH56_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_63226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3734964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH56"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041318038" evidence="2">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="95" mass="10046" checksum="B738FB7FBF6BB52C" modified="2024-01-24" version="1">MRSQIVHAFIGLGYALEVGCRAGTAGTKEKTSSVCSSSKGLTTNPAQPPPFSQANLSSTAPMIQTNIVSRLSRLTRRVLKGNSENAGLETLVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHG8</accession>
    <name>A0AA38JHG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1083133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHG8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041434738" evidence="3">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3729987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="128" mass="14415" checksum="D5E407C5D0DA9864" modified="2024-01-24" version="1">MLFYISLFALVALLVLIVHRYRSSIAPHIPHRVKSMFPSFNHYVPLSTFADQAGAGMSSSNFDIEANIRDGDSRTGLDERGTQEVMEIMRQERVNFDQARLIRQNRILANNGIDPSGMPLDSKAVTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHZ5</accession>
    <name>A0AA38JHZ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1120786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHZ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="302" mass="33414" checksum="AF6C616C3D36C303" modified="2024-01-24" version="1">MRFRAGVENVTTFFRIMQSVEKLQKKCIIKFTEDNMHIICNNDANEGGIQVWSQIKIGSIFSNYRIQSNSNNEITVNLSCEALMGALRSVSTSSGASNSASGSSYETDEVIVKLAKKNDQAVLNFEITGTTRAGRKVKIEHDVKIEVMKPADVAKLREPMCPEPDIHVLLPSLQKMRTIVERLRSMSDILAIRASHNGCLQLSINTESVKVDTEWKNCNIPQMMKEGASQDSANESPDPEQLFSVLVSVKSFLKFLSSHVVSTTTIACVCQNHCLILYVYIGDVADAGGVLTFYIPAIIDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIF0</accession>
    <name>A0AA38JIF0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_996530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIF0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="79"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="605" mass="69070" checksum="7484CA155A3B2124" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIJ4</accession>
    <name>A0AA38JIJ4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000045">
        <property type="protein sequence ID" value="KAJ3725623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIJ4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="234" mass="26170" checksum="345ABFB239B3651C" modified="2024-01-24" version="1">MVPYHRQKCSKIDEQVFVPKDQSFFVQISDQLLDLRRILAHGQKTIYGWARDRNGESQELQGKRRRCKVELDVTRSNLKMIEKNNEMLEGAVRSLSDKHGTNPRDVGSSYGTAFFTSLPSAGSLAPQIQLHLLLHPFSLHRTFIEVLPQVWLQLVLLFYIVHAGYEPKHQQPSTDSCGRERQSDITGAGISNRDTNTNTSIAGSDASDTPTPKSKTSNAISSLSDLSSRMTVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJH2</accession>
    <name>A0AA38JJH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1129536</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
            <location evidence="1 15">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 15"/>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJH2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="186"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3736389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="976" mass="111072" checksum="4115B87211230CD3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJJ6</accession>
    <name>A0AA38JJJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_376288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJJ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="601" mass="66866" checksum="934C1F274FE797EF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJQ3</accession>
    <name>A0AA38JJQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1181095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="52"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3732478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="466" mass="53080" checksum="1FEA77FDE8D7EC25" modified="2024-01-24" version="1">MLNDDEDVFDSVTWESPTAPVYADHIPPTSLGYRQSIDSNEGGPHDPKWEGHLITAVTDPQKELAETKDAYVSYLVSAKTNLPMFSTPNPSARRRFQDFVFLREHLVKDFPACVVPPLPGKHRLEYITGDRFSPEFMERRRLDLHRFLQRLARHPTLQRATLVRAFFESSEWNVHMHQHLAHPPGPEPSPGIVDNITDTLLNAFSRVRKPDERFLDMRESVDKFEDGLVLSERLWTRVRNRTTDGNPESGEDLTADYHDLAVAVQGLGFLESGITDPLNHFSNTLLEFSALFRHTTQTTTDPFLIQLHSLLTYSHANRAVLKLRDQKQLDFEELSDYLSGVSAERDRLAAIISGHAGSSGLGLGSYLKDRMDAIRGADDDRSRVEKMKKLDVKIKELQDAVTTAHETSDAFSDETLREQHVFQHAKEAEMKEMLGNLADGQIEFYKAAMEEWDRIIPVIQRIHVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKS9</accession>
    <name>A0AA38JKS9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dopey, N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1003483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="319"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3723564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1774" mass="199035" checksum="6E9072BAC5CBF471" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL10</accession>
    <name>A0AA38JL10_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_175157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL10"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3733977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="332" mass="37157" checksum="5731439B69BAEAAF" modified="2024-01-24" version="1">MKKKVLLMGASGSGKTSMRSLIFSNNPASSTARLGATIDVEQNHVRFLGDLILNLWDCGGQDAFMDSYLTTQRSTIFQHVGVMIYVFDAETREMNKDLEYYRDCLDSLTQYSPEAAVFLLVHKMDLVQEPKTTMFEKKREEVQKASGDVIITVFGTSIYDESLYRAWSSIVHTLIPNAAVLNKHLNIVAAACSATEVILFERTTFLVIATSTASSSLPASASTTSSPSSISSPTYTSSPPSPLDPHQMHPKRYERTSELIKAFKWSCSRVREEFHSLELDMYDFTAVLDEMTRNTYVMVVVHDPTIETAAIRLNIRMARKKFEELQGDSIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL30</accession>
    <name>A0AA38JL30_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1040089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL30"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="605" mass="68128" checksum="F84AF3DE87FCCE15" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLE8</accession>
    <name>A0AA38JLE8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1078585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLE8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="336"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="165"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="271"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="342"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="470" mass="51612" checksum="689F032DDFF765F5" modified="2024-01-24" version="1">MSPVKVQKIVCIGAGYVGGPTCAVIAQKCPDIVVTIVDLNEARINAWNDEEYRLPIYEPGLVDVVRSCRGKNLFFSTDVDKGIQEADLIFVSVNTPTKKSGVGAGFAADLNYVELATRRIAAVATSNKIVVEKSTVPCRTAESMRTILEANAKPNCRFDILSNPEFLAEGTAINDLHKPDRVLIGSLQSAEGLDACQALSSVYAHWVPRERILTVGLWSSELSKLAANAMLAQRISSINALSAICEATGANIDEVANAVGYDSRIGPKFLKASVGFGGSCFQKDILNLVYLSESLHLPEIATYWRQVVEMNEHQKSRFAKRVVDTLFNTITNKRITVLGFAFKADTGDTRESAAITLIRDFMKEKANISLYDPQVEEAQIWQDLAEASPNLSLENIKKQVKICSSSLEACKDAEAVVIATEWKEFKEIDWETVYQGMNKPAFVFDGRLLVDEDKLTKIGFKVITIGRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNV7</accession>
    <name>A0AA38JNV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1153017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNV7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="306" mass="33572" checksum="666F4D5321338C8D" modified="2024-01-24" version="1">MEAKIPRADSEFICQFIRGNFHVYINRLQISTYFSGVEMSLSYSKSCLIGAIMETMAYGMYFLLLCRCSRILWKRHIKGAISIYLITATIILFVLITMRMVLDNYAAVTAFTYAPLTPNAAEVYFGSFGNGAMFRTGTYVALTVVADIFIVFRVYAVWGNSIYAAIVPALLAVADIVAGALTIQTIHQLTAGESPDGSSLATHLLIFYGFTLGVNVLSTFLIAFRIYLVQRQTRLIKSSMDLNLAIEVVVESAALYSSSLVAMIAPTATGSNVQYCMLSVISPIVGIAFSLIIITALRSTTQQFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR83</accession>
    <name>A0AA38JR83_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_76136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR83"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041450750" evidence="1">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="103" mass="10941" checksum="D721FE6FCF84A945" modified="2024-01-24" version="1">MMKLTYTLAFVLCSISVARATFQCAICPATIVHDGITTNFVLAIEDEENVVQCSYDDSDNDVPICAYFNFDGVFLIGTIGTNCPNTVPLAVFAGTGTCIAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRR5</accession>
    <name>A0AA38JRR5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S5 domain 2-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRR5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="257" mass="28183" checksum="FF443EE026520BFB" modified="2024-01-24" version="1">MTSSAESSKVIVSNLDSFIRRSQPLPEPKSTSQEIRDRSSTFVANIFPAATPEEANSHVHYLRKVLHASRPATHEISAYRCMVLKAGKTGLAGPEDFELKTGCDDDGEQWAGIKVLKVMESLAVLDAVVICSRWYGGIMLGSVRFTHIETCVAEVCRTFKSKQELEDCIAMLSTLDDILKQLRAELAVLSGPSASTSSTDDSPRPKMKPPDYSSWTESDIPKARRLVTAREKAVASVKSMIAKRSAAAATATWYPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS67</accession>
    <name>A0AA38JS67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1150690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS67"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="269"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="664" mass="74636" checksum="8A86F86F859E4FF6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS97</accession>
    <name>A0AA38JS97_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_986915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24036" checksum="A95F5E17C4E11FAA" modified="2024-01-24" version="1">MACTSAAKRICCPVRPHRYLSHPPTRCLHASVITHAKFRKPKNDKIPFTEVHLVENDGLVKIGLQDLLAKVDTEDFYVELQATEPLAVVKIINKKEAAARRKLAKEQRKLNTRKNVKKEFQFTWGMALGDLEHKLGRAKAELKRGSRVDLVFAPKSGQKAPPMAQMHERLQLIADKVADLGTEWKTRELSRGIGALFVESHGVQHDETEDTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSH9</accession>
    <name>A0AA38JSH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly(A) polymerase</fullName>
            <ecNumber evidence="13">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_1150528</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSH9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="19">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="18">
        <location>
            <begin position="207"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="17">
        <location>
            <begin position="354"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="511"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3736213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="609" mass="67683" checksum="82F6F144843AEE68" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTT6</accession>
    <name>A0AA38JTT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_773955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3736000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTT6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33694" checksum="7D90892E96BC706D" modified="2024-01-24" version="1">MTLKSLGRTNEALLLVQPLVKSSKQILGINHPGTLSTTLTLALIIRALGQSIDAFSLLQTLVRKYGALMGPEHPKTLQVNQHLACTLLDLGRIHEALQLQQSVLETSQRVFPPNHPRVMTAIQTLAVIFNALGDHDNALQLQQPLVEQSKQVLGNDHRDTLRRIQNLAITFRNLGRFDEALQFQQSMLQKATRIWGPAHPSTLIKIQSLAITLRKLGRFNDALEIQQDLVAVSKRVIGSDHPFTFRRIQNLSTTLAYLGRKHESLELMNPLVDKSVQVLGETHPDTLCYIKSLRLLESLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU47</accession>
    <name>A0AA38JU47_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_821337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU47"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121649" checksum="4997825AB7FC7ACF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JU87</accession>
    <name>A0AA38JU87_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1051662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JU87"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041284297" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14849" checksum="CF49466C19965438" modified="2024-01-24" version="1">MCIPMIIFVAVVSFVVCRASDCLADCDKSIGRGSHDGDEAEFEEGMCHSQSLQNELWSTIPAGYAFKWRPTIIGGVPRGKPNDAYRSGMRSGSISSVINNCRGILLPDWKKKNLSRSACSIDLKKSHVKLETNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVE6</accession>
    <name>A0AA38JVE6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1111886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVE6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF215">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57503" checksum="7349182679A2F3D5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVN0</accession>
    <name>A0AA38JVN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="9" type="ORF">DFJ43DRAFT_1052252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVN0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="256" mass="29438" checksum="36193EE70B7E2065" modified="2024-01-24" version="1">MAVGKNKRLSKGKKGIKKKVVDPFSRKDWYDIKAPSIFDVRNVGKTLVNRSQGLKNANDSLKGRIIEVSLGDLNKEEEQSFRKIKLRVDEVQGKNCLTNFHGMDFTSDKLRSLVRKWQTLIEAHVDVKTTDGYLLRLFAIGFTKRRPTQVRKTTYAQSSQVREIRKKMFEIMTREATNCDLKELVQKFVPEAIGREIEKASRSIYPLQNVYVRKAKILKAPKFDVSKLMELHGESTDETGTKIAKDFKEPDIQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYG8</accession>
    <name>A0AA38JYG8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1046543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYG8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="325" mass="36056" checksum="7833DC7FF095A294" modified="2024-01-24" version="1">MIPVGGAAFAAIFCESSLHGMYTVLFVTLLQSFRKSRRNQAKISWMATTIQSITILMYILSTAHLILALQIDYTAFAINRNADSVFNRLGGYPTSLAQLGIEFTNCVLADSILIWRVWVLWNCRWIVVVFPICLVLASATSSYGFVYQVSKINSTSAEFSDVFNPQAENWSLVFGSCILVTNLLCTGLIASRIWWQNRQLQITLGRRMASRRYQAIFFAILESGAIYSAAWIILIVLELIGSNAVFTVVDSVAQITGIVPALIVVLISRSVNGLQTTYTAPSYPMFRHRQTATTNQFTTTEPVAQETPIHLVAGNSLTGDIEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K0A7</accession>
    <name>A0AA38K0A7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_989942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K0A7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="554" mass="61600" checksum="FF163B7F97708740" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K0H5</accession>
    <name>A0AA38K0H5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1052565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K0H5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="343" mass="36799" checksum="329E71AE6C24F446" modified="2024-01-24" version="1" fragment="single">MSVRTVQTSFTSHSTSTTAMSMIATANVLATVDLNVAYPPGLESYRADKGLVSRGRSYSGSPARNSYSTQANGGSISSNSRSFNRSGNSKRFPQGMRLPTSSYHQTQNQTRRAGFSSSPAKSMKQENSLLGVPSYQHTLRFDPFGDSKDIPLSPSPIITNSRRSSNAPEPLYTHYYYYDPSTNRPTLAYADEKSSTANLTASTNYLLDTLLNGRRDTSRSPSPPHPTTAAPAPIAVQPMIQPPSQPRSPSPPHSPRPRASAISRPSSPVTSPVMSSRSTASVSPPPAPAAPPALIKVSKAQRDAIARIVASMLLNRADGVSRRARRCNSTGYVKSSLSRVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1X6</accession>
    <name>A0AA38K1X6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1047093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1X6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="817"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="817"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="924" mass="102615" checksum="21125CC503739183" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRM5</accession>
    <name>A0AA38MRM5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA/RNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_960074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRM5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20454" checksum="236DF7F604581363" modified="2024-01-24" version="1" fragment="single">MPKLSTHPPEFTPTGRYTEERKAIIDKVHEGDFLWPEERKLMHHLMMEQEKGFAWNDEERGKFREDFFPPIDMPVVPHTPWVEKNIPIPPGTYHEVCRAVKVKIDAGVYEPSNSSYRSRWFGVLKKDGKSIRLAHSLEPLNKVTIQHSGLPPATDELADQFAGYSCGGILDMYVGYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MST8</accession>
    <name>A0AA38MST8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_463781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MST8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="704"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="897"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="897"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3730066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1130" mass="121281" checksum="390BC871606BE6BA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTE7</accession>
    <name>A0AA38MTE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1078065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTE7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="474" mass="54202" checksum="A7ABE94E38DB9548" modified="2024-01-24" version="1">MSVAHLPFELLCEILVSCDVDTLYRCALVCSTFKEAALPSLYRTITLKTVHQVGEGLNFGALETLDKYIHLRSYVREVKFFFVLSDYVRRTRHTNPDQKVPQNIWVNSLAKLLHIHSFTFCHIPFFSYPQSQNRFLPIPHELIDVTTAALSNCNELNELNLLYRATPSDISRLSHLKNVRHIRLGLPSREVLVMIRPWIEQCDSFSVRDAYALDSLATIRPHVANLTTLHIGPHHALSNRDLLQLLHCTSKLQEVDVFYDNFLNVQMLNKESRSSLSLKYLHKVVLRHQGVSNKSQFMELFNWLEIVILASPLQSISILSDDGRECNFAMPLMNLLAKKPQLEFLNIPQVVLRHPSLRTLFGRLRSLRVLSIMLVDVNILSFYSSASPGELSFNLSALYLRSNRNTCPYSLTTSQLRQTVLSLRGSAGYLRRLSQEKQTWKALWTSGPQTGRQGVDPLKDEYGSYGDATEEDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTH9</accession>
    <name>A0AA38MTH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1077709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTH9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.620:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="118" mass="13456" checksum="B69A8CE8ADB5F18C" modified="2024-01-24" version="1">MSAQQSQGIQTLLEAEKAAARIVQEARQYRVQKLKDARTEATKEIEEYKKAKEAEFKKFEASHAGTTSEAQANIDKDTEVKLQSITDSYNSHKDEVVKKLLDRVTLVKPELHRNLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU07</accession>
    <name>A0AA38MU07_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU07"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1030" mass="110472" checksum="944F9AA5F9520FA1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUG0</accession>
    <name>A0AA38MUG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1044326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000116">
        <property type="protein sequence ID" value="KAJ3711669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUG0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="202" mass="22839" checksum="35799DB3ABE9908B" modified="2024-01-24" version="1">MPRSRQVSHQATVSFMVKAYRISKTNFTSPLSIVTTASHPPRRHDVHRLPLVEHGFSGWPVPQAYIHDCDVVYARTRYRVFFQQHRNLPMNPVLFVHGDLIIMRVGKLNTTNVVNTQAGDPLLLTLLAFSRVDGGCRRSFILYSLNQWRIYDTIESHSNNDFLLGNQHLIIISLHGLLIGYFVFYKAGLGTATGPALIIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUW4</accession>
    <name>A0AA38MUW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal recognition particle, SRP19 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1103323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000089">
        <property type="protein sequence ID" value="KAJ3714641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUW4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3714641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="317" mass="34206" checksum="9D2D1326D3B53C77" modified="2024-01-24" version="1">MSRKTVLVEDEFDDDTDLPLPARPLLNTGAKGPLLQEIASDNDSEDDLDFNTSHRAGPASPSSQPQFRPDGASQLPKNTVTDITPYKSWTCIYPIYIDAKRPYGTGQRRVERAKSIWWPLSKDIAEATNRLGLGTLHEVSKAHPRDWENPGRVRVQWKKEGRLMNPTIKTKKQLLEMISLQIQHLKPENIPRPPYSTSPLTSGNASAATPTINAAPSSNKGKAPATTKSKSPIAPQPKQIVGGRRLPVPPEPLLPLASRLSPYSPALPTGVLIDTVKAGMNATENNAGALGAPGAPSPFGAPGGPQKGKRKVVRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV06</accession>
    <name>A0AA38MV06_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acetolactate synthase</fullName>
            <ecNumber evidence="13">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1034819</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="13">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000119">
        <property type="protein sequence ID" value="KAJ3711439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="17">
        <location>
            <begin position="64"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="15">
        <location>
            <begin position="262"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="16">
        <location>
            <begin position="468"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3711439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="650" mass="70536" checksum="E5FE341563C7465C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV67</accession>
    <name>A0AA38MV67_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1065658</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV67"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="48"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="13">
        <location>
            <begin position="181"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3734009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="373" mass="42801" checksum="FADFBF34653B2A6D" modified="2024-01-24" version="1">MEITLHPSTSMLDNDPVYEEKDSLDIKAEVTKSTTEFSQVTQSHERWVTLQFTWAGKSFSLDIADSDRVFDLKTTLHELTKVPPERQKILGLVKGKLPPDQGRISDLKLTTGKKFTLLGTPEGDEIKDPSQLENLPDVVNDLDIDFSKDLNAVKRYKNDQRNIRKVKEMTDKLNVNIIHPLREGKKLLVLDIDYTILDTKPLTSGSLPPAECARPKLHEFLEAVYPYYDICIWSQTSWIWLETKLVELGMIGANRNYQISFVLDKTSMFTVFTERDGKPWQHSVKALQIIWNHFPQFNATNTIHVDDLGRNFALNPQCGLKIHPFKNAHTEEAQADRELDKLARYMVYIAPLSDLRTLSHANWKTVLKSLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVC0</accession>
    <name>A0AA38MVC0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1228093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVC0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="559" mass="58957" checksum="D43B076095A39F34" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVC9</accession>
    <name>A0AA38MVC9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1161563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000112">
        <property type="protein sequence ID" value="KAJ3712092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVC9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3712092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="18218" checksum="470A2137FD7316D6" modified="2024-01-24" version="1">MPTTPPPHLRVMIDRGPEVEREEGTEDGCWGQRGGGVHDFGICKSPSSSPLSFDQLLPKNHKLGMIPREGELLGVSSIKIESKNYHEPAAFRVPFGHNPPSPSWVLPHQPPLRPPRNRQSAQRQGDVRAFLGDGRDTAPRSAVGLVEFMRKEEYGELATVFGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVD8</accession>
    <name>A0AA38MVD8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1104020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVD8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3714568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="52" mass="6033" checksum="05854B4AC65606D5" modified="2024-01-24" version="1" fragment="single">LSDLADTLINEGWDREALAESEWGDIKDVYKGSGWTSPTFVRLRKICKEWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWA3</accession>
    <name>A0AA38MWA3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1058194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWA3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="309" mass="34775" checksum="B77433CE64197B09" modified="2024-01-24" version="1">MRVAKQDISSAIRSFLSRCSIPYQKLPMDVTFLELCYTEATKRGYIVEGPDPLKPFIPAGVAIAFTSYAHLGNTSVQVWIALYTACAIYCDDKFQKDTDTVAVFSERLMRGQPQEDRALNAFVDLILEIPRHFPRVIANIMVSSTLNLVNALLLEDQTKGMKVSAWADNYPTFSRIMSGVTELYGLAIFPPEIPLQSFIQALPSLMLVIMNVNDILSFYKEELVEESVNQISLIALCRDCSISHAFHSLIHETVEAHQKIIRILEPDAKALDAYNKFASGYVYFHTSLDSRYRLNELELELESAASESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWE5</accession>
    <name>A0AA38MWE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1006864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWE5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3716334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72150" checksum="82117CE5B56E7210" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWG9</accession>
    <name>A0AA38MWG9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_747505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000067">
        <property type="protein sequence ID" value="KAJ3719019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWG9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3719019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="330" mass="37349" checksum="D787DB86C32113C7" modified="2024-01-24" version="1">MAPFDLDACIEQLLRKQLLHEVLLREICEKTKEVLMRESNVVHVSAPVTVVGDIHGQFYDLIEIFRIGGYAPNTNYLFLGDYVDRGLFSVETISLLTCLKLRYPDRVQLIRGNHESRAVTQTYGFYTECVRKYGSSHVWTYFTDMFDFLTLSVVIDDRIFCVHGGLSPSIHSIDQIKVVDRFRGECHALTLFAIFMFSLEIPHEGPMADLVWSDPDPEKEDFAISPRGAGYTFGSGVVHKFLEINKMTHILRAHQLCMEGYASLFDRHLSTVWSAPNYCYRCGNSASILEVGPGGSMYFNVFEAAPENERDGPTQQAAQTASGKPPEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWQ5</accession>
    <name>A0AA38MWQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1199980</name>
        <name evidence="2" type="ORF">DFJ43DRAFT_967703</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWQ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3721411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="86" mass="9475" checksum="3EFFB1CBC3B9B879" modified="2024-01-24" version="1" fragment="single">ALTAVLGALASISSVEVAEPVAKHTSMLSGQMWLEEILYGHPDRCHTQFGMSTEVFGRLLTQMYASGLHDSRWVSAAEQLAIFLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWR8</accession>
    <name>A0AA38MWR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mu homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1092176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWR8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="171"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3723527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="439" mass="49093" checksum="4E152A616A59D89E" modified="2024-01-24" version="1">MISAFFIFNQKGEVLISRLYRTDFKRSIADVFRIQVVSNPDVRSPIITLGSTSFFHVRVNNLYVVAVTKTNANAALVFEFCYRFINICKSYFGKMDEEAIKNNFVVVYELVDEINDFGYPQNSEIDTLKTYITTESVVSAIQAPEVSSRITAQATGATSWRRNGDDVKYKKNEAFVDVVEVVNWMGSSKGTNLRADVDGHIQMRAYLSGTPECKFGLNDKLVIDRSTVGLSGPSSGLADRGGSDAVELDDCQFHQCVRLNDFDADRSISFIPPDGEFELMRYRATSNIKLPLRVIPTVTEIGTTKVSYDITLKTTFSPKLSATNIVVRIPTPLNTTDVDVGILGTGKAKYVPAENVIVWKIPRLQGGQECSLSAMAQLTSTTTRQVWARPPIDIDFQVLMFTASGLIVRFLKVFEKSNYHSIKWVRYLTKANGGYQVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX10</accession>
    <name>A0AA38MX10_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1158564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX10"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3721384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="181" mass="21005" checksum="FEAB156B0D59B2B4" modified="2024-01-24" version="1">MGPAIVRFNSFWALFQDFSSSLRFMINDLKRQLLDFSSSGRLERMEQFRCRFLELRNIERCLRELSTEIVRLEESLVNFQIVLPCALATCTLLENAFQDIYTLLSRVSLQTTVHVIKRIACGGANSLEDQEPYSLLLASLSVQTFKITEISKTLQRQSLKRFLDIVRRDRNVIFSSRTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY39</accession>
    <name>A0AA38MY39_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DMC1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_503874</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY39"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000097">
        <property type="entry name" value="Meiotic recombinase Dmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="105"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3728105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="343" mass="37373" checksum="7AD79C2DBA8F0F7A" modified="2024-01-24" version="1">MPPRRAPSQGSVVPSRPASPDDFDDGPGFDTVDELQQHGINMQDILKLKSAAINTVSGVNMTTRRQMLKIKGMSEAKVEKIKEAAHKILGSSFSSGIEVQDKRKRVLAISTGSKSVDAILGGGIMSQSISEEFRTGKTQLAHTMSVVAQLPPDLGGASGKVAYIDTEGTFRPDRIKSIADRFGVDGNMALENILYARAFNSEHQMELINECSLRFAEDKDFRLLIVDSIMALFRVDFSGRGELGERQQKLAQMLSKLTKLSEEYNICVLLTNQVQSDPGATMTFVAGGALKPIGGHILSHASATRMFLRKGRAEERVAKLVDSPDRPESEASYKLDEGGWADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYA9</accession>
    <name>A0AA38MYA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1082990</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="371"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3729962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="574" mass="65901" checksum="C18A36B9FDC72C22" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYT7</accession>
    <name>A0AA38MYT7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_24699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYT7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="200" mass="23284" checksum="29155DACE65367ED" modified="2024-01-24" version="1">MLPFSNLFCEPLPPSIDELLTNREQILQRYPRRNFSRWRISRASLSFFSSRDNASASFYRLYEFVVLGWTIQLRNELEYFCTSHPGWAVSDLPDPADTKDPARYAFLAGLTYLMCEAFNRRIELGLPRDAPAIVTDWEELKRRPQVLERVPDWVKSVSPLTEAVRIPDEKGNFVGTNDPEVCTPLSRFNIIMPYPHIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ63</accession>
    <name>A0AA38MZ63_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1084530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ63"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="533" mass="56186" checksum="D0E999557DD87DB5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZD5</accession>
    <name>A0AA38MZD5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1083446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3729094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="219" mass="25540" checksum="E5A564F43E369F30" modified="2024-01-24" version="1">MRILFVSGFSSNTRARELAYEFERFGPLVRCDVPAPRNSHSRAVPYAFVEFRDGRDAENAYHDMHGRNFDGHRLSIQWARKPPSAGWRVADGSAPPPRSDRDSRARSRSPRRRSPERRRDRDAEPRDRRRNSSRGRDRDEARTPPPPPYATPMAAGDDHESDRRDTKEYKDSKDGEGDHRGSIRDRRGGSRDRRDRRDRDDDDREARFRREDAGPTLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZV1</accession>
    <name>A0AA38MZV1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_1081270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZV1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="232"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="435"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3731057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="596" mass="65538" checksum="C58448EBAFB749D8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N033</accession>
    <name>A0AA38N033_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1079157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N033"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="694"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="756" mass="86927" checksum="D6030A76249E7E0F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0L3</accession>
    <name>A0AA38N0L3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0L3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="225"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="566" mass="63989" checksum="605B7AF3CCC8E3E4" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0V8</accession>
    <name>A0AA38N0V8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1068479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0V8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="471"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3733320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="578" mass="64644" checksum="0D11F0BC9FBC11F3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1E2</accession>
    <name>A0AA38N1E2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DFJ43DRAFT_1223107</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1E2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 21" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="244"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="571"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="786"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="731"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3733846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="850" mass="91392" checksum="5D6329A5148E5780" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N200</accession>
    <name>A0AA38N200_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1152129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N200"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="303" mass="33992" checksum="4F49319455850DEA" modified="2024-01-24" version="1">MPATNPNQLVEEFKKSGEFDRLRRELFAEFQKGDHMHSFNKKTEDVVQQRFASMKTRSFISARFNKDESNLRTELLQEIQRYPYVETSVNDMPTFSDQNFNDNLKSSIMRILQEEPNENEKHWDSKENDADEKHLNNPRDSGHSDYKREEDDTMDESADKKDEEKETKTEEPGSVLVNGKHELTTTASLSTQVSVNDNDTKEPDVTKDASISPPSLTRRSSSNLSSLSSVSSLSPSVPAESSTDKPTTTHVPDNLSLPRPAADVHEGSNHTVQNGDTVKPVEPTLQQTSEDNSDVVMGGTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N391</accession>
    <name>A0AA38N391_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_992578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N391"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="88"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="340" mass="37171" checksum="EB77B1D07D2EB7C7" modified="2024-01-24" version="1">MVALGTPFQCLTYSLLILPVLLLTVYFLAAFPNPPETVYLHPGLSSLPPSCKSWKLYPEDFYPGGAYASFPDGKTRYFLMGPDDGKKIVLIHGLSIPAMIWKDVAPSLAARGYRVLLYDLYGRGYSDGPQTKYNSNLYITQLALLMQHIKWDKAVLVGVSMGGGLAAAFTASFPDLVEDRVVVISSAGLVLTSDMSRTTKIMSLPFVQALTSSLVVQKFLQHLTDSSNDTAPVDPLQEIVRLQSAHLPGYNAAISSSLRDGPVRGEYRSFSSNVWDTRKLLIIHGTNDNTVPYKYAAMIQTAVPQGCKSEIITIDGGGHDLTISHPDTIANQIDRWVLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3S7</accession>
    <name>A0AA38N3S7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1051940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3S7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="193" mass="20833" checksum="513B6E8966158E7C" modified="2024-01-24" version="1">MSTKRVQTDNIHASNVASNNPAALSHVVSPDLTAALRNVGMRARKSVLEGYALNPDPQYGTSSSRMKAMSTGTLFQSSRDVALSARADQLSSLMSPRKRHRSASPIDNGMDGTCNEDASMSLDAGEHPERPVKPLRKSGRAFRQIQSLPAGALFRGQSQSVPENKLRKMDEGEDDWSLDLAASSTTCDPKSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4E8</accession>
    <name>A0AA38N4E8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC-2 type transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1129900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1162"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1193"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1317"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1434"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="117"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="820"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1112"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3735962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1463" mass="163556" checksum="FCF4C0FD4BE29E93" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4G9</accession>
    <name>A0AA38N4G9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear protein DGCR14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1186264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4G9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3737100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="529" mass="57873" checksum="83BFA4AA6B22CE6B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4Q0</accession>
    <name>A0AA38N4Q0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_990037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4Q0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33012" checksum="0B5392B6C67AF28A" modified="2024-01-24" version="1" fragment="single">MIWDTVQSPFASVIGTNYVPSTAELEKVKDLLPQPQIELSKVLSEINRVQAALDDLLSQKQSIENYIDAHKSLLSPVRRIPPETLAEIFIHCLPTDSLYAVRNLAEAPLIFTTICRDWRQIALNTPQLWSSLHFFLPSRLSDDVFSRRMAGITLWLERSGSLPLSISFHDGYENDPLIISQSRPAMTVSLIRSLMHFSDRMQDVYLSLSSSSFPIFDNLSPSFPILTSLHVRDKRLRKHDLNGTGSVGFGPLLHRMPALEKLELNGFNTRIGNNYRSLPCNWKLLTELVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4T0</accession>
    <name>A0AA38N4T0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1110560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4T0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="432" mass="47990" checksum="5B50D7529D45A4CF" modified="2024-01-24" version="1">MGQVFTVDLFKPLGGVNTYSRALAAFLVPLEGEPLVSHLRIVDKYSVAPATTYLGAEFPKVLAKPEVDYKQANLTVPSIVQSIFNPPEGKGPYDYVFDLTGEVRHDRTEMILINTTCNVARMLGQEAAKRKVKAYVRVTLPFYETTSKGTHDEKDDPKPDGTIGTWWHETLRMLAAIEECVVAFPLPFISSTEISSLNLVILRVGFVYGPYVEFGDITSAITVGSVYGYLKKPMKSVWSPGKNPTNTLHVEDLAGAAWASATWMASLGRKEADSLAGESIIFHNEKSKVSQVEGMPPHDSKLVAPLFNLVDDSNSTLLSVGQTVTSFFGTTFDFFNLGERTMYKFMDDAVEDINEHHVGGWTQMIQSSNPPIPNTPLSAYMDKYALEKHIVALSNTKIKEVIGYKLKRPQFNHDGIKDIVDKWKEEGNWPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1A5</accession>
    <name>A0AA38J1A5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_138308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000133">
        <property type="protein sequence ID" value="KAJ3710767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1A5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="243" mass="26636" checksum="EE80683A3F7C472E" modified="2024-01-24" version="1">MHMASTLDACFKDAEETAKKDIKARSDALDTLEANISDERTRSEAERLIEFYGELSSDRFVKDAPKIMQSFLSHGDACTEIEAEALRIASQDLSNIDFDTMDIMVPLREYNDVLDRLGTLQMEVFALESAILRLTVSTTEPSSEKSAFMSDESDDPPTSPQSSAEINDNAPNIPDSTAQSAAARSQIAPVFKACLPIIRARGQNITMAQQLVEGAKQNLSMTVHLQSLGLGSDDDHSDVEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1D0</accession>
    <name>A0AA38J1D0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1044444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000125">
        <property type="protein sequence ID" value="KAJ3711091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1D0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="188" mass="21669" checksum="970C197B09DA80A2" modified="2024-01-24" version="1">MYNGPLPYVFEDRTGQLYGSDFDDMYDRLFYRVARDSQRTATMVYDMGRRANRHRDSLPFHQRPIAILDFKPDQSMGSICYASNGSVAVPINRYLRRTSIFGGSLSRKFTGSDGREYRWSHRSIQGQEWTCTTGPENFLVAHFDLKPADVRAYDVSGNTLTVFEQFIHLSVEILASLTIMRHIAQHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J237</accession>
    <name>A0AA38J237_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1135073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000113">
        <property type="protein sequence ID" value="KAJ3711875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J237"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="63"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3711875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="295" mass="33222" checksum="A7FDAE7DB7A05B18" modified="2024-01-24" version="1">MPLKLPFTPSFPSFSAKTKKSSTEWLRRQSQDPFVKQRSLGADITSTKTSSILGPSISSPLTFRSRSAFKLIEIHEKYDEFLLKPDVRVVVDLGAAPGAGARLSYKSTSLPPKPLDSYDPLNIDAELGLFSLSASHPRPVDRLSMDPIPGVYTLKADFLHPQTEDMIRALIDDFSHNSQKLTLATPDTPKVDVILSDIAPNITGVPTVDSEANFQVAQAALQFAYKYLRTGDEIGRVRGGVLLLKHFAHPQMDQFRREVLERYFRDVIYTKPRASRQESKEGYFLCRGFWPKEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3C7</accession>
    <name>A0AA38J3C7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1006930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000080">
        <property type="protein sequence ID" value="KAJ3716253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3C7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="2">
        <location>
            <begin position="151"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3716253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1028" mass="116894" checksum="EDB2BE4070E9EC88" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J543</accession>
    <name>A0AA38J543_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endosome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_753161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J543"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="142"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="324" mass="36738" checksum="E2D9E7BAC78A50A3" modified="2024-01-24" version="1">MTAMTNFFKSIKSHILTKKDEQDTRDSQPPEWAPAPEASHTYGQYNEASDQEYRDGISYCQKHPLCLTSLISSRFIDQIKSEGAKAWGLDIPQDHYRFSGRVDNIPPESKGQNLVHITTDKHCKDYCLLSNLPITAGLYDSSGREGVYYEVIIHEMNPPQSFLVIGTSCRPYPTFRLPGWNRESTGWHLDDLRKFFEDSDGGRNYTDNGHQLPLPWNPENRSEQYIPLGSTVGCGYIFKSGSIFFTYNGLRLPNAFDGAHLPRHERDVFAAIGVSGKTKFDVNFGGEPFRWVPGNTWQWRVEGLVGRLNSIGDECSERLPAYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J563</accession>
    <name>A0AA38J563_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1091086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J563"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="144" mass="15046" checksum="F76FCD5160A44689" modified="2024-01-24" version="1">MYSACTACQGLDSSILTWVEFRASCGSSLSNTTYYPSDVVTLGNTSIPFYATVDPSTWQNAIFNIDQAQNISEQGHADVYGAPLASSSSSSAPISSKSTNAAAIGGGVAGGVVVLILGAIAAWWILRKRRRSGVAVIKRRTGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J689</accession>
    <name>A0AA38J689_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1107038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000113">
        <property type="protein sequence ID" value="KAJ3711883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J689"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3711883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="272" mass="29377" checksum="ABEB3713BDB10B9B" modified="2024-01-24" version="1">MTSEFTLSPHRSTAELTTTLSMVRVLVLGGHGKVALQMTKILAAHNHKVTSVIRNPDHTKDIIDQYPENPSLIDPVMASIEETDEEGAKKLMEGIQWVVWSAGAGGKGGPERTKAVDEIAAKRFIKAALLAPSVTKFLMVSASSSRRSPASYWTESDIGTFKKTWESIGVYSEAKTVADEYLYDESRKSPKSNWVDICLRPGSLSDNPGTGKVDLGKAKLGGSVPREDVAAVAVELLEKENGGGLWVDLIGGSEPIGQAVERVVSQRITSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6P5</accession>
    <name>A0AA38J6P5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1008340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000103">
        <property type="protein sequence ID" value="KAJ3712990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6P5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="176" mass="19835" checksum="879398980E073C4E" modified="2024-01-24" version="1">MASPLWSPAGETAAQLWYERSILAGLFLGAIGFGVHATLFFQASRSLYIHRNKGHNRLFLAYVIVVFLLSNIGNATNIRFGEMVFIDYRDYPGGPGAYFVEQSTALAAVLCNNVYICLSWFQDGLLLYRFWIIFGKRRIYLGLPVLMFTASITLSCLLIAMLSRPTLTLWSEISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6Q1</accession>
    <name>A0AA38J6Q1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1135118</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000117">
        <property type="protein sequence ID" value="KAJ3711634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6Q1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1910:FF:000005">
        <property type="entry name" value="Cysteine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="16">
        <location>
            <begin position="37"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="17">
        <location>
            <begin position="529"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="718"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="681"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3711634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="781" mass="88469" checksum="719A7F9ED4BB5BC2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7L5</accession>
    <name>A0AA38J7L5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1225122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7L5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041378881" evidence="1">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="194" mass="21971" checksum="6090D5FB65A8B887" modified="2024-01-24" version="1">MSLIPSSFSPRLALCFLFLAIFHAVVSSPLSPRTSEKIFDLEIMLVRKDGNGQYIETPSPDNWNGQITADDQWEICIHIWCFSARKNAENADKFVYPGTPGKKLDELGLLIGSISFSNLAQREAIFKYMTSNAFYAGTTNNLEYLNSLFDYISGLRRDPSAKNVRVGIVRSKKDKTKIRWKICYQVIKAKKAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7V1</accession>
    <name>A0AA38J7V1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1041378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7V1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="62"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="348" mass="39327" checksum="89425B15DE1F397C" modified="2024-01-24" version="1">MEFAATKAWKEAVLKRVIYTNIPDAADSPAHDTVLYVGEQVVLDTLRRKYRNLPRQYVPLPNGLVAVQSTPSLSLGVFAKRAFKPGDVVVRERPFLIAAADIGFDPSAGGKKVNPLIGNSVLGEILKSAERHFLPPNRDGFAALLTDYSLNPVHDLMKDMFRSLFRIGEKDLETSGVYKDYRLVSRVASRINHSCSPNVVCHFDEATFTFNAVVTREIQIGEEILTTYCPLELPRAERHRYLLPYNIDPCRCEACEMTDQEGSNQRRKMIYDYDMHKVIQLSPRKALKELIGVRNAIEEENLQFLPVYPMVLQLMGSFWAKLGKSTLSEGLQKQADLYHSIHKSGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7W8</accession>
    <name>A0AA38J7W8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1002169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7W8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="805" mass="92083" checksum="CD8E13B769BF252B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9I5</accession>
    <name>A0AA38J9I5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1161029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000096">
        <property type="protein sequence ID" value="KAJ3713762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9I5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3713762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="151" mass="16201" checksum="DA3F39B991D4C330" modified="2024-01-24" version="1">MDGNLKVRIGEVDDAVTFWFAEPLEPLAHPTSKMQTQISSDEDQSSMTLKLQATLDSVRSRSSPAAKPRKSALLTSSSLFNSNRNAFNDLDSESDTDLTPSSSLFSKTSSIESMSSLSSTASSPVSKSSNLSLPLEIPASSKVPVYVPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9U2</accession>
    <name>A0AA38J9U2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1156034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9U2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="200" mass="22384" checksum="1AB44EB02594BD5B" modified="2024-01-24" version="1">MSFGSDPQDFVQYALSLPDNISDDSSHESESFEPYTDSNSEIDSDASDMESNASNDASDTSEVASWDEIIRRADPRYRHRFLRHMMDYYTNPDPDVGPFDYSDSEFNYSHDSLVNSAHSSDSFHSAHSSIAGSESGESSHDNGSESSPEPPDYMGPDGRLLESERERRRNLSLCFYCGGDHFRSHCLKLRAKYSGDSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA10</accession>
    <name>A0AA38JA10_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type III/BRCA1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1103694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA10"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="80"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="196"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3714623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="471" mass="50490" checksum="DC77ED3DC30F659D" modified="2024-01-24" version="1" fragment="single">MNNKHESFTFTVGKLDAGMAILLGERAHLIEFPSILLPPGAIAGSIVNIAVHQNHAEEKRRDGEFWALQNEILNEFGVELPEAPELKLRNVTQTSVTLEWPSIKLATAKLRSLDIYRNSQRLAAIPSPMTNTSTKLSGLDMQTEYSFQLILRTTAGTFPSNLIRVRTHSIEDTSGICVCFGNCQDDVLLENAKMALREMNAKWSDKIQIDTTHFVCTTPATTPNGAQASGSAGGAPGVEYQRALQLSIPVVTPHWILACHSEKRMVAIGAYYLGAEPSASTHSFRPQSMSQASQSTSSLAARANRASLPAPARKSPTSTTMPATPESHSAFVNQPNSLGSPIAEEESPSKAESTPPSTTSPPLDDSGASTPTASKRKSRSGTMNRDFRFPPNATETGAARKSPPAALPVKQQGQVDDEGEGEQTAKMITPSAIEVPPPPPVEKERSTGSLGSRHSNDEGDDDVGDTVEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAE2</accession>
    <name>A0AA38JAE2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyranose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1093368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAE2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041296913" evidence="7">
        <location>
            <begin position="20"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3722158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="607" mass="65891" checksum="8DE04BD32E072DA2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAF4</accession>
    <name>A0AA38JAF4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1004085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAF4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="240"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3722188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="585" mass="64900" checksum="CD48E5C983FEBC00" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAJ6</accession>
    <name>A0AA38JAJ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1159180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000065">
        <property type="protein sequence ID" value="KAJ3719572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAJ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3719572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="213" mass="24141" checksum="72B53B948BDE69AC" modified="2024-01-24" version="1">MDSGMYSYPHHYNPAEMQDVPVASSSYDPLTAAYLQNQSARMPFSGPSHSSYAPEPQQDSQSSYIGSESLTASHHPYMDLSGLSSASSSGRGTTNPRNGSPKSPHSPDHPLPQAPRIRRSPASRHLPLPDDFDDDSDDEPLPPNASERERLEWKKRRNTKAARRSRKRKMIYTERLEANVEKLRLEKEMWRTRALTLRQLLKSHNLPCPDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAM9</accession>
    <name>A0AA38JAM9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_652000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAM9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="139"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3723470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="331" mass="38709" checksum="FCDAB8E467A2B514" modified="2024-01-24" version="1">MAFNGTAEAGNAMDALYSGTDFSSLNWTEQKWVAWYVWWGNPVIATGMISFLMHEIVYFGRSLPWIIIDAIPYFQKWKLQPNKIPTPQEQWDCTKQVLWAHLTVELPAIWLFYPMAEFVGMKTYQVPFPSLSTMSWQIFFFMFFEDLFHWAAHRALHTPLLYKYVHKIHHKYSAPFGLAAEYAHPAEVMILGMGTLGGSLFLCLFTEVHFISFFIWVIVKLFQAIDAHSGYDFPWSLQHILPFWSGAEHHDFHHMAFTNNYSTSFRWWDRIFGTDDKYLVYRERVQAVKAKATSKEEFLKAEQALMDEVLAEGLKAENAVEERSKRKAKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC61</accession>
    <name>A0AA38JC61_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1159257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC61"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041486094" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="22"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3719104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="527" mass="55676" checksum="90C64083CB83A678" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDE0</accession>
    <name>A0AA38JDE0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_679503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDE0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="128"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="540" mass="61597" checksum="1EEF04AEC91A007A" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDE5</accession>
    <name>A0AA38JDE5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_681408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDE5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37966" checksum="59D4B91036877D22" modified="2024-01-24" version="1">MEKHNIHFQSPLSLISALTINADTEEFSFRLDLSRSESFPSHRFSCVDDKFHADIRYSTYQVPQNAAHLQLKLGDCLGFGATGTVYSAHISNSLSDLSPPVPQELIVKFARLNHCRSLAREAWIYNCLDENQRLTGTVVPRCYGFFTSKLTESGVDYTTLSSSELPFELPWSLYEFDGNPDRDDILHDDFDDEVVRPQTWNPGHIITKDSSPWNSWTPDPDDPLVAVLLLEKGGQRYTDFDDKDPLVREDVELVCEDLEFAGIAHNDFRMPNLIRAPPATSVCRRHKRVHTWNIIDFNQAWPLDLSVENFPRDTNAVLNSRYRSGYFYGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEG2</accession>
    <name>A0AA38JEG2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1091207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEG2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="64"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3724151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="577" mass="62684" checksum="00D63371D138390B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEJ0</accession>
    <name>A0AA38JEJ0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1140583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEJ0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3724236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="369" mass="38825" checksum="B82915DB06BCD3D7" modified="2024-01-24" version="1">MVNVTIDDSAPSVIYYPSSAWNSRSASTPCTTCTANPDTARMFDNTFHDGTFSPTTGSNDFPNVPLTASIVFNGTAVYVFCALAESSTSPDGDSDMSFYIDGSLKGTFVKTAPGNSNVYDYSIPVFSIDSLPSGMHNFTLQNGHVNGTKSLVLLDEIIYTTVDDNSSSSSSSSSSSQTSTTAASSASSSTQGSSAEDTTSSTKKNLGSIIGPAVAVPVVLILAAIGLCFFLRRRKRQRVQQQSNQRRTTLDSPGPVTAAWTSEPLSIPHSNSALSGGIAPFSSRQHSSTNTEAAASGTSFYDPYAQTQPQSSVYVSSTSGGDTDGTPTSASFQPRAVDGELPPAYDQHLNKARGANLRLKDRKTVVMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFR8</accession>
    <name>A0AA38JFR8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase III transcription factor IIIC subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1084505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFR8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="230"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3729045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="560" mass="62989" checksum="440037EA913CF540" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFW7</accession>
    <name>A0AA38JFW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1095847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFW7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3720270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="194" mass="21611" checksum="CB6B917CF19AE71D" modified="2024-01-24" version="1">MSEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVMHFCAGLPIILVGCKKDLRRDPRVIEELRKTSQRPVTPEEAMAVAQKIGAKHYLECSAKSGEGVREVFQYATRAALLSRPGKKKGSKCIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGF1</accession>
    <name>A0AA38JGF1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein PET191-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_989754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGF1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3736447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="108" mass="12076" checksum="74DA16F527438A18" modified="2024-01-24" version="1">MSSSCQGLLNALKDCLMHSDCVVKQGKLPSDCLKHHTDELPEECQSLRKATFECKRGMLDMRKRFRGNIVGSRFQYDPDKPSAQSDLGVESSMPISTCEFYLSRTAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGF9</accession>
    <name>A0AA38JGF9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1146764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGF9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="3">
        <location>
            <begin position="130"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3728065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="385" mass="42666" checksum="02B2FB33CFC9678B" modified="2024-01-24" version="1">MDMTPSTITDIEIFRVPPRWLFVQVKTSDNIFGWGESTLEGHTEAIEGAFSDLRERFIGAIADNIQDIWQNAYMGRFYRGGPVLMSALSGLDIALWDIKGKKLGVPVWQLLGGKVRDRIKVYGWIGGDHPSAVVSAAEARKAQGFTAVKMNGTDAISWVDSPALLEATVERVKQVRSTGLDVGVDFHGRLHKGMAKQLAKLLEPLCPMFIEEPLLPTQPEEIADLSNAVSIPIALGERLYSRWDFRPYLERRAIDIAQPDVSHCGGISELHRIASYAETYDVALAPHCPLGPIALAAFVIQEMSWKMHYNVAAGEALGIEADLHSYMANPEVFTVKDGYVAALQGPGIGVEIDEGRVRKASELYMKHTPWRNPLWRGEDGSLKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGK0</accession>
    <name>A0AA38JGK0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_489691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGK0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="244" mass="26981" checksum="4E60560EF8B735B1" modified="2024-01-24" version="1">MELREGISRDPNPGHKTQAEVLLHAYTRELDRQRGYLGVGDVDVGDVGVGDVGEYEEEYEEEEEEGEEGEGEGTEDDDDDDDDESFHYPIQTPPIQTPPTPILPTLPPLPLPPSLPLQPQPQTRPQRPNPTQTQTPTNLSHHLSLAPDFRVPTHEVPSLSRSSSSTTPHTPQTQTHGLGSGLGLGLGSGRGLGRGRLNQRWEKDENVKSCRECQKRFGLLLRRVSGLVVGFFVFVSFLGFKFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH23</accession>
    <name>A0AA38JH23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_670455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH23"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041336536" description="alpha-L-fucosidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="333"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3722160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="806" mass="89248" checksum="3B5C9A2FC608D153" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH43</accession>
    <name>A0AA38JH43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1075212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH43"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="175" mass="20245" checksum="A77C846C3302B7D0" modified="2024-01-24" version="1" fragment="single">FREALSLPSASTVGPFIPQPMYKPHTISDRRRYVDEVNLDKPIYFWMENPSECGISLSDALHSRVRRLGPSVSIRLEWPGYRQWSRQIPTKDFRTPPGPITKAKLAKNVAKCVHRFMQERHNQSLEDESDSRWRVGRSDAGENSIKLEDLILVSMHHVSMGSWQPQLRLSRPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHM0</accession>
    <name>A0AA38JHM0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1151442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHM0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="480" mass="52743" checksum="BC6FB9885A40DC22" modified="2024-01-24" version="1">MSLRDEKAGSEDGAEVVVHERPTGWKGIYYHPLTQIVLLGFICFMGPGLFNAVNGLGGGGQLDRTTSANSNVAIYSAFAVVGFFAGSINNTLGSRLTIQLGTFGYCLYIGSYLALNIHPGAGAFVVAAGAILGVCAGLLWAAQGSLMLAYPTEPEKGTYIAVFWAIFNLGGVVGSAVSLGINFHNTAGTVSNSTYIAFIVLTAIGICIPMSMADPKKIIRSDGAKVIVPLHPSWKTQLLGLWLTLRTDPMILLLFPMFFTSNWFYTWQFNDFNGALFNIRTRSLNSFLYWTSQIFGSIAISFILDSKLQRRTRAFSGWTILMLMIFVTHIWAYFYQIQYIRPGASDIDILDKRYVGRVFLYICFGLLDSMWQTTSYWLMGAISNDAGKLAIMVGFYKSLQSAGAAGVWRADAVGIPFMNIFISTWVMLVAGLIFALPMIHLRVKNHTEIVDETLVRMDSKGHIREVEQVKNEAAITTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHZ6</accession>
    <name>A0AA38JHZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_989753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHZ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF67">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="25"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="513" mass="57005" checksum="AEB2675A3FD4E62F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI54</accession>
    <name>A0AA38JI54_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1098320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI54"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="101" mass="10651" checksum="96A9359C63335070" modified="2024-01-24" version="1">MYSLFLVLSVGDSTSIGSIILAGLSILSVALGTRLPWASSSKEGTCSAMSALSSLNPSCMRYSALARKSSASSLMPWTISDILFCTTRARRHCCFGHAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJJ7</accession>
    <name>A0AA38JJJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sjogrens syndrome scleroderma autoantigen 1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_621245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJJ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051888">
        <property type="entry name" value="UPF0148_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537:SF1">
        <property type="entry name" value="PROTEIN ZNRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537">
        <property type="entry name" value="SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32886" checksum="269F1D84DED6A882" modified="2024-01-24" version="1">MSTVTDVSNIIGEYMLKGWILTDSPCPQCKNIPLMRSPKNQTPTVHFCANCDGDARRIVQTSTSPSLTSNSSISPRNTHSRSSTPATEISDVPSSPTFSIPAETPESRRRREQSDRASSEIGNRLLKGWALLGEECVNEDCFGIPLVRPPKSSGENHRECVICGRLYVGEGELVEAEPPHSSALQSSNQSFPMSTDISSSNVSGATKYHVTESIDRPTAPPEKQPTGTMLHPTTSPNDESAISALNITTHALEQTLISLSGRLTSSAGSSIFVDPHTISSIVDAISKTTQALAEVKKLKQVERAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK09</accession>
    <name>A0AA38JK09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1202006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK09"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3722716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="953" mass="108233" checksum="59D9A1D65156D9BA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK34</accession>
    <name>A0AA38JK34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1075407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK34"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1130" mass="119989" checksum="06E4F05F422C36F3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKQ7</accession>
    <name>A0AA38JKQ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1154677</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKQ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041337221" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3732320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="240" mass="25086" checksum="05D56B0B8DEC1F9F" modified="2024-01-24" version="1">MSFARLASLSIVALSGVIHTGLAHYTFPDLIVNGTVTADWEYVRETANHYTNDPVTDVTSDAIRCYELDSTSAGAAGIATVVAGSTVGFQPNIDLYHPGYLSAYMSPAVPAANSDNAGLDSTWFKIWEANPQYSAETGMTFPTQNEVQFTFTIPESTPSGQYLLRGEQIALHVASTVGGAQFYIGCAQINVVGGGDGTPGPTVAFPGAYSATDPGILINIYALPAGYAGYQAPGPAVWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKY7</accession>
    <name>A0AA38JKY7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_309354</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKY7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="110"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="434"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3732425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="685" mass="76628" checksum="A77E93331FBF451E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL40</accession>
    <name>A0AA38JL40_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_634481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL40"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3724179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44360" checksum="6D137F14ECE3BBA2" modified="2024-01-24" version="1">MEAFSSKYHELGIMAECVSLIGVSVLSFCLSRRVPRWRQWKHLTWGRTCVLLVLLDSWLFVFFSGLLSSGIGFSTSYTTCSLAIYTCISFYAISKILIYAFLSEKVYIVWTGGNQTSRLKAKVYLLCAFVLLGYVVVGILTVVGRDSTVRRDGVCVIGLKAYATISLIVYDMSLNIFLTAMFLWPLWISHPMSPRLRSIAKRTLYGASTSLISSMINIAILFLLGGNELGWICLSSCVADVTINSLALFWLSSSSSLSGDVVQDRFSLPTMDMSALTFVRIDSTRPTAITSAQDTLQPQLGSSTTIPEAFFDYIPSVHMTLRGDHEKQTEHQFKTSKPLSHERTCTIAYPDISGSNILPDSHYTPNFGTTMPELQPQTDSESGQHTARVEEEKDICDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JL58</accession>
    <name>A0AA38JL58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1040012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JL58"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="535" mass="60410" checksum="0A3D1ED5800DAC72" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLA9</accession>
    <name>A0AA38JLA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Quinoprotein amine dehydrogenase beta chain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1155276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041220788" description="Quinoprotein amine dehydrogenase beta chain-like protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="35787" checksum="484F41626FDB4EBF" modified="2024-01-24" version="1">MHASFGLIALLSSAAGALCATVPYNRSLTLNAATLVTPEVVHTFPNGTNMENLAVRASGQILCTIITGPDLFQVDPIVDSPATLIHSFTGYETLFGIAEVQPDQFYVLAGNASAATLTSVPGSWSAFHVDMTSFDSEGTATIDKVADFPDALLLNGMGLLNQAEGLVYVADPFAGAISILNVNTGDHYVAINNSLTVPAAPFTTPLGVNGVHVFQQPDGPLYVYFSNTAQSLLARMPINATGVPTGDAEVVASGIIADDFTFDSAGNVLQAVIGSDEIVKINPATGTITVLAGSPNNTELRSVSAAQFGRLSNDSTTLFVTLNGGNLGAGGPVVPGAVKMLELGTTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLH5</accession>
    <name>A0AA38JLH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine dehydratase alpha chain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_998377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000001">
        <property type="entry name" value="L-serine ammonia-lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase beta chain" evidence="11">
        <location>
            <begin position="53"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="10">
        <location>
            <begin position="286"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="627" mass="67970" checksum="76A0C0DAAB0EA390" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLV0</accession>
    <name>A0AA38JLV0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1133499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLV0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="109"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3724936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="605" mass="67323" checksum="DBDA8022CADA7DCA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM23</accession>
    <name>A0AA38JM23_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_996370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM23"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3732830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="122" mass="13819" checksum="50A62FB8DF9A6BB9" modified="2024-01-24" version="1">MALARPTSKLPTGANRILFVKNLNYQITGEDLYDLFARYGSIRQIRIANETKTKGTAFVVFDDVMDAKNALDHLNGFHLQERYIVVLYHMPAKQDAAAAKADLARREEELAQLKEKHNIGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JM58</accession>
    <name>A0AA38JM58_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1070425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JM58"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="310" mass="35022" checksum="53480DE1BD1025AC" modified="2024-01-24" version="1">MSGNDLILWLTRRLRSTVKVESGDPVAIPNFSPTQFEVLRVKWNRCRRQVPHVIYNGAIFNWVESILLVEPPFEEEKDVFCLELSSAIGSPEFLHYLLKANDLNSTLHAAVPPFGLGFLLSCESFRGELKSFEWLDMILGDVMRGRSGNNGESNAPVKDLYQDWLRRDRQPREHDHILTVESTRMLSTSAEIETSAFETANRKRPEPSADVYELGSASNSTSEPPSKRPRSSPSAPVAVRSRSGLLQWLSLTTTQIKPDHLNVHHEGIASRKHSNDLNTSKVCTDPEDPSGWVWYKRPLLIPHSSDHCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMB8</accession>
    <name>A0AA38JMB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1059145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMB8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="218" mass="24679" checksum="65796BFF936B7358" modified="2024-01-24" version="1">MGKAPIGPSHISKVLDALKTEPKLSLFGVRSLKLSYAYRNDHFGARNFVKEELPRIRYANPNLKIEVDRVLKTKEEHWRPEMELQLDNGTIKAINMHDKWSTTILQELLDLSGGDPWKKWKRTRSERGLPLLKGEDEAAAYVSPDRGAATYMNLKEWRGSAQARALAQEKAEKERMEKAKAKAKEKDKKKAAEVHVAELSPEVLENLRTKTGAAAILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMD3</accession>
    <name>A0AA38JMD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_270712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMD3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43380" checksum="F175A7088800C1AD" modified="2024-01-24" version="1">MALRRFAQANNASTASPSRSSGSSNASPASATTGLPITPKPRGRVSIGIHQSPASTPSISSSIPFDWEAAKSRRPPPYATPLQNRSRGGRNGGSNSSSLNGTPARKAVIKRKGLIERVTTIPSQIAFEISQFPNNVPLPTPRTSACVIGGLLHFLHLCVRVSQARSAQSSDLEWNEMLRESEGRSWLDWTMPMTLFLIGASIVNAVYAFTRIKLYRLHRRVEPVSSPNAKFVDSDDLDFDSIEPPSLAVRFRAGLWSAFIAFWRFLLGLKPSTKLPSSTKKSTRVQQLEIWTPGDLEMMLFNIYSPVHSLLWMATNSSNWIIMLLIMGIVGLQLHTMMISYKALIKDKDILHAEVMSEYNESFVYPRINPIRKDVAIMTHQSEVVNVWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN59</accession>
    <name>A0AA38JN59_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_994932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN59"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="463" mass="52213" checksum="36638BD4A3CC2170" modified="2024-01-24" version="1">MNRHQRGLVDACFEENQYDEGIALLSQLRTPAVLPSASHMRQLLYFSLYPPAVETSPIDALLSPSKNSRQQQRSLTISSHTAASACSLLAQYATSMRPQGVAQVLPSYNRSNVDRGDSSESLIAKESYCISEAKNCWNILQKGFIHRAITSSPTTRRARRTTVYEDEDEDEAEDDFKFGVSNVVAEHAWLVLDFLLILFERDECETEARGLPRYSPLLLNQIPAPRNGKGARWEADAPLSIILYALTQDGNEQRLQMGARLAHLLINLCSTNLFDFTMFLNSVFTRVYTTAPKEFLALLMSLPPTVPVLRFRIALLHKFNSNGSKSATRDASLRAKPQARAKPIRRAPDNTNSIEEQSKSQLTSTSILSQITLPTFADIQRSMEELKLNLLNKDIPYSWIQFQLWTSFAMYQTRLPLEMRDDGWRGLLQGGNLSQRLDELFDSTDPEATVYKEILNDVLSGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNH2</accession>
    <name>A0AA38JNH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1130826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNH2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="333" mass="38413" checksum="CB7B01B2D0A089FF" modified="2024-01-24" version="1">MIRPRVFIDFSVGGEPLGRVIFELYNDSAPKTTENFRALCTGEKGRTTSDIPLYYKSSIIHRSIKDFMIQGGDFTKKNGTGGESIYGGMFADEDLTRPLDSEALLCMANRGPNTNGSQFFITLRPCPHLNGKHVVFGRVLRGYDEVVKKITEVPVDGKDRPLNPVVIENCGELELKKPPGMLTCRVLPRIHLRITLVKRAPSESESETAKEEKSSKSRHRSRHSHSRSRASDDSDSDSSRERRRRKKSKRKHRRDKSEEVIKENTDKLNFRGETEEEYDARLEREEKERLEAERKQELQKIKERYEAESYTQDGVRFKGRGRMKYVDPDVNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNY9</accession>
    <name>A0AA38JNY9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="13" type="ORF">DFJ43DRAFT_1212001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNY9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041203555" description="UDP-N-acetylglucosamine transferase subunit ALG14" evidence="12">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3735754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="229" mass="25277" checksum="887761F38392E970" modified="2024-01-24" version="1">MWSLTICALVLLVPLVLIRVHSTPSSSKISGGTKATTQVRKLAVFLGSGGHTSEMLAMISSLDFDKYYPRIYIISEGDTLSERKASALEATKTANSGSISKHADAYTFLVIPRARKVHQSLLTTPSTALLSLMHCFYHVTLASTYHRKTFADVLLLNGPGTCLTLCLAVYLNKFLGLPSPRTVYIESFARVRTLSLSGKLLRSLVDRFIVQWPQLLEDGKRGECRGWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNZ4</accession>
    <name>A0AA38JNZ4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_168101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNZ4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="79"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="227"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3733880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="329" mass="37973" checksum="C13EFD7E1917F798" modified="2024-01-24" version="1">MTSDEEISGSDANSLIYNPDQDPEAKRELRRKYYALQLQLQDFDQKCKQKHRAHELGDILRAADILSERVRDTPEALLDADVIVDLSSKSGRLTRELQFDSGLFNLDEYVLNLVRFMGGRKLEPESVEEISDEEDDPQLVEPLQWERIGKLAMRKSKRVTVAGFMLGPFLLEDSRKRKRKQSTRSKINKADERRPQEITAEELQRSTNETMRNVLTIHAILQDIGPANLFQLIINPASFAQSVENLFYLSFLIREGKAGLDLGEDREPMVYVPDDDPDQPQMRTHQHPESRQTVFELDMATWKRGIEVFEISEPLIPHRKLSQTRIGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPR7</accession>
    <name>A0AA38JPR7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCDC174 alpha/beta GRSR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1137554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPR7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057464">
        <property type="entry name" value="CCDC174_GRSR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25449">
        <property type="entry name" value="CCDC174_GRSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC174 alpha/beta GRSR" evidence="3">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3734285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="389" mass="43446" checksum="099E2D2F144354B2" modified="2024-01-24" version="1">MHSTKSRAKGISAGSLFDLKADLAKKGEEFARDKAAGKTYTLATERPANEKKSSKWSLSNKGVQSRAARDVRELESVSQPTLENARIALERKSKKYTQLIQGKTAGLNEKQMEALLVDFDAKGIDSNWESDSDDVDESLTVPTHDEDDPMVDYIDEYGRTRTARKSEVPRQAKLDEEIQEDDDEGVIRNPRVLQNHFPTFHLDEDRRTQIVNEYAEENNPLDKHYDPNSEVRDRGAASYSFSLDEQTRQARLDDLKATHLETNATRKEMGAVDVRPGEIEGMQAPEVGRSAKGSEKRKREIEERRKILEAKRKKAKTTTEGSQPGSDSTSTSCITANAKQSHIADPFASLESATFSMPSPNHGKSKAISSDADAFLAQLGNEMLDKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPU9</accession>
    <name>A0AA38JPU9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1080125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPU9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041299528" evidence="2">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="183"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="408" mass="41186" checksum="228DB0059791EE8B" modified="2024-01-24" version="1">MVLCKYLALLATVFSASLAQNTTAITDALSALGLSSFALAAAALNGTSGGQALLSTVLSGGNYSILAPNNDAFSQASSLASDNTLLVDTLAYHILRGSFSSSNSSTFNLTSATSPNHTIGRSMLNDSAYVTLEGNASQAVAWTIESNTLVFLNQATNISIVNSTRINGTGLDIYTIDGILSIPPSMSSVLANATNTSSIAGLLNSTMVPSSNGTNDTIGNILNAQRGITLFAPSDSAFSEVSSSLPVLEGNLTAFTTVLQNHIINGSTVYSSEITNGSNFTSAAGEPLTFVTNSSGTYVTSGSTTAKIIATDILSMNGVVHVIDNVFLNIASDSSAASSAYNSATSAATKLASETGIISATAPAASSSSSSSSGSGSSNNAGVASVVSTYFMTSIVAIVSFAVFGVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ99</accession>
    <name>A0AA38JQ99_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_215347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ99"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="243"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="539" mass="60957" checksum="0A8ED3555D7EC23F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRA0</accession>
    <name>A0AA38JRA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRA0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="123" mass="14032" checksum="5BE4EAEEEBB371C1" modified="2024-01-24" version="1">MAANAIDSVSPILSLAEIDYRTSSSHGSPGYLTVADLTLQLRWHKKHGIRDLIPTKESSWGRREDKIMLLKSAVEKYNDLHASTVDHSRGEEEEEPEVTVQDLQDYNSEEYDSEEDYYASSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRK1</accession>
    <name>A0AA38JRK1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA isopentenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1177689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRK1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3737427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="506" mass="57784" checksum="38FA7AABE5E91CDF" modified="2024-01-24" version="1">MSMKALRPLIAICGTTGVGKSNLAVEIALQIAKSGHQMYNSAKIINADAMQVYAGMDVITNKIPLSERQGVEHALIGFKSPHEQYVVGQWVKDALHAIDDAHKKHQIPIVVGGTSYWIQHLLFPNRLAKDINLVDDLERPPSSIFQASEELASAIKLLPQELQDLFVCLPDPAPSAESDPEEAFRLYNLLKALDESVAARWHWKDTRKVLRSIRIIQETGRKPSELIHEQSQDILQPRFRTLCFWVYSKPEILKPRLDLRVDKMLEQGLLDEVRDLQALPKNPDPSSNEEEVDPASNYSFGIYQSIGYREFHKYILAPDPSKEEFSEAVRNMKTSTRQYAKRQISWLRNKLLPMLYAANESEENDEHPEPSTFTYLLDATELGENWTKIVRDPAVNITDAFLAHQPLPDPLTLSDVAKELLDIERKDTDPRAVLNARRKIICPVCTIDPAQPFMVEEGKEWKLHQKSRIHRRRAYKPLSEAEIEERKRQGRRKKDSGKVSDNGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JS34</accession>
    <name>A0AA38JS34_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_321238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JS34"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="469" mass="54049" checksum="A3ED783F8F5285F4" modified="2024-01-24" version="1">MYRASELAGAYEVLGLEQGVSLEVVKNTYKQAALRTHPDKNPNNPDATTEFQRIGEAYNILLRQLDTSHADSFDDPYDSEDEYEDSLQFYMFLFESFLRDRARFYPRGHQRSRGQQQKSNYMSDFSHVYFNSPSREQEPEPKETAQEQTERLRRSREEQEAAELRRQREAAVRRELKEQDRQQERLAAEQRQKARNGAKKAKVQAQRQQAEDAAHARLEKVQKNRSAVFRAARQGNAEEVKKGIWENDVDAAGGEIKAGHEEFLKIPPKDPKETLLHIAARKGDLDLVKWLDEHNAEMEERDSQNRTAFHTAVQHGHHEIVSYLIEHYPAKDSDHEQIYTLPPSTNVLSLALQSHEPQVVWMVLQPENELASTRDISNAWSWINSSEGRREMTQHSKVVTGDVVEKFDDICTLLRQFSGFTPQATPIRHRVNHNSPPSVKEKPQTGQRQPSRRARGRGRGRGRGRGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSL8</accession>
    <name>A0AA38JSL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1055997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSL8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041232343" evidence="1">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="35"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="282" mass="31252" checksum="B0DA3C29090A90AD" modified="2024-01-24" version="1">MIPSIGFLLFHVAPVLAFVNHKILQSRATNSSKAGLAWPNGNADDIDQYVTTGKVSWYYTWSPDAISSTSIEFVPMLWGNNSVDNFSSTINETISSNNVTAVLGMNEPQQSGQSNLTSAQGAELWQTYLEPLKSQGIRLGSPAPSSAPSGKTWIQDFLTACNGSCTVDFIALHWYDINATAFIEYLEDFYNTFQRPLWVTEWACQNYNGGSQCSYDDIVLFLNATQSYMDSSDFVERYSYFGAMQNLQGVNQDNALTRDAKAMAVHLNCHKGISHGNLVDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSX3</accession>
    <name>A0AA38JSX3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_17290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSX3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="222"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="353"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="426"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="573" mass="62402" checksum="7C22997405514A35" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTN0</accession>
    <name>A0AA38JTN0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1143927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000007">
        <property type="protein sequence ID" value="KAJ3735965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTN0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="300" mass="32834" checksum="5F566147370D88D1" modified="2024-01-24" version="1">MHGAGFGLKVLGRPTVFNQITMLEQSNSTLLQYPTQFTQNIVPKQIHSHNDYWRDVPLLSALSLGVASVEADVWFINETLFVGHELAALTPSRTFDSLYIQPLLNILARQNPANAFTANQTTPNGVFDTSSSTPLQLLIDMKTDGNSTLPPVLKSLEPLRQLKYLTTYTNDTLTISSITAVGTGNTPLEGIKSLSPRDVFFDAPLTQLNDPSTTYNSTLSPIASTDYASAIGWDGIGNISETQLGNVERFIGDAHIRGIKARFWDTPGWPVRARDGVWEMLMNSGADWLNADDLEAASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVV2</accession>
    <name>A0AA38JVV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase family C78-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1047310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="105"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="449" mass="51361" checksum="57B2A0BAF7BE83A2" modified="2024-01-24" version="1">MGLQCQLCWENIEKLTVSERQRHYDNHSEGRSSPQLGSNASRRSDSWFSKGKSKMMFVNREKEQDVFWHPAMQTPPPTNFIPGLIPVLKKALLKSHAKGTTTRAVLCYERAVYISRQMWDASWGCGYRNFLMSCAALMDQPYQPLYFPLLDQPVSPGIRNLQTWIEEAWKNGFDVEGRAQLQKLVNTNKWIGTSDICAAFLSRGIPAELVDFEVKDLKKGLTPLTNWIVRYFNKYSQRNPGSTINAALLGASPVQCARCMPLIVQDNKHSRMVIGYELTRTGAVSLLVFDPSRLPSKRLRSLALSEFSSTSSKASPGPFQGERRENEGASSSAPIDTTNQRMKMVHVDKNENISDTAWNGEVEEIQFIEKRERDNIEFIDAGRNGNASKVDKDIPLDEPSYSDVLKHFRWEKRSLQKRHKYQILYFPLEDPLTKSEMRKRKILTSERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWT7</accession>
    <name>A0AA38JWT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1064581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWT7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="130"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3734303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="373" mass="41327" checksum="3099C235DA5362EB" modified="2024-01-24" version="1">MKLSISLFITAILTSASASNVLELNPDSWDDVVGTGKPGLVEFFATWCGHCKNLAPTYEQVADAYSHVKDKVFVAKVDADGVGKELGRKYGVTGFPTLKWFDGKGNYEPYESGRDLESFTSFITEKTGVKSSIKPPPPPSYRILDYSNFDEIVLDPKKDVLVTFTAPWCGHCKAMKPAYEKVASIFETENNCVLVNVDADDKKNEALKTRFGISGFPTIKFFPKDNKDGIAYEAGRSEADFVNYLNEKCGTQRSVNGGLLDTAGRLADFDVLANKFFVASGDLRDSIHKEALALSSTIGDASKHYIRIMEKMVNGTEAYYEKESKRLESILKKRTLAPAKLDEIKIKSNILRAFSEKPKEDSESNIRRAAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYR2</accession>
    <name>A0AA38JYR2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1037205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYR2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="109062" checksum="FAFFBFC419F25FB1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K2M1</accession>
    <name>A0AA38K2M1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1163941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K2M1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="254" mass="29040" checksum="447D87B97265E5C8" modified="2024-01-24" version="1" fragment="single">EQAQRIIEFEVAAKDSLENFALKDREVNKLQLLLEESQSMNESQLAIINEKDEQIRVGLEKLHHAEEKIQATEDRVSRVKEAAKRGVENMSKNFDALRNAVEHLKTRYEVSVETVSKMRDGLESSRLTISNGLKDLKPFMDPSGLHLVKANETRVLIQELQTDRNDAQQVIDFLKDKLHNLSTQLVEANEKVVDLENRRKEESNSMSRSVALWESTGHQVEELASKLKHREKEDAEVLAGGFKLEIQLTDANEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRI1</accession>
    <name>A0AA38MRI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DFJ43DRAFT_1097461</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRI1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="20">
        <location>
            <begin position="248"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="384"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3719135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="431" mass="49150" checksum="695989D7EC7FE433" modified="2024-01-24" version="1">MMKFVGVYVAERKHRISASSLSLIFVEHTDMVWTRILKCSTPFCASRSPRYFIPTFSLHGQIIKHVTRFADGTRPISNGSLENSKVEHSQFLANASTHSKWRDATPGNGTSDAEDDELGGVEEGVGKLLPTTSHLFKLILPLGRKGPNNSVIPTVLLLHPSQPLSHTSRLILASLPRRSETAISVSFRSSSPHHHRELEWSDSTDIGDFIRDAARASEFSIHFIPESDTAEGSKEDEQTISVRVPTFADRTRFLRRRLDVINHQLSEMEGLKRECDREARKGARRMAVGGFGMLVVYWAAVARLTFWDYGWDVMEPITYLSGLSTVICGYLWFLYQGREVSYSSVLDRSVSSRREALYKQRGLDIEKWMELVSEKRHLMREIGQIKEDYEQPQDEESKRNKAIDESEDDDQENKHPLDEPEEEKEKPQKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS10</accession>
    <name>A0AA38MS10_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1092900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS10"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="78"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="597"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3722722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="762" mass="85578" checksum="4188E63A6FFC013C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTE2</accession>
    <name>A0AA38MTE2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1155244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTE2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="138" mass="14440" checksum="2CB38FDF7C1304E1" modified="2024-01-24" version="1">MLLGREPGVVSAKQKVEHGGITSIAGHGSLGQKSLTHTYGEVAASAGWWVRMEWMGELVVMTKASEKDGITKYFVNRLSIHLDLLTLVNFTGRPAQRGGERHNTTDTPSPLTSSNSTGASGLSSSTSTSGAGTSAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU46</accession>
    <name>A0AA38MU46_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="8">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="8">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MEF1</name>
        <name evidence="10" type="ORF">DFJ43DRAFT_1009243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000138">
        <property type="protein sequence ID" value="KAJ3710504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU46"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000029">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="64"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3710504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="772" mass="85449" checksum="E7535F05008A6524" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MU79</accession>
    <name>A0AA38MU79_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_54278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000106">
        <property type="protein sequence ID" value="KAJ3712754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MU79"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000099">
        <property type="entry name" value="nuclear transcription factor Y subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3712754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="161" mass="17532" checksum="9FB47D4F8797839C" modified="2024-01-24" version="1">MSEGIAMVPAPIVAPIAPREQEDGSRLEQPEDVNEEPAPITDQEVGEYREQDRYLPIANVSRIMKSSVPSTAKIAKDAKECVQECVSEFISFITSEAAEKCQLEKRKTIGGEDILYAMGSLGFDNYAECLKVHLAKLRVHQHGNAAAAGGSGRGVDRIDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUK4</accession>
    <name>A0AA38MUK4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_242309</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUK4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="451"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="43"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="270"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3733214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="727" mass="79252" checksum="071ED2E9970EFF2D" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUZ7</accession>
    <name>A0AA38MUZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1161813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000121">
        <property type="protein sequence ID" value="KAJ3711274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUZ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3711274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="582" mass="65236" checksum="B35450E597538673" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVA9</accession>
    <name>A0AA38MVA9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1006739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVA9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3716332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="141" mass="15302" checksum="434E61581B4AFC66" modified="2024-01-24" version="1">MPKVVSRSAVSSSTDAQPTASSAAALRVYYCICGEFILVIDTNLSALPRRQSDQSTIIRCRESDTAAARVFKLNATSGDPILIERNGGHERQYRFLCPRCTLPIGYQSTPPPVKSGPFLYILPGALTQMQGQLPQGALDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW32</accession>
    <name>A0AA38MW32_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1042659</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW32"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="604"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="778"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="820"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="985"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3719668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1194" mass="128096" checksum="18CDA751A78ACBD0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW35</accession>
    <name>A0AA38MW35_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1043287</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW35"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041449954" evidence="12">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3716737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="338" mass="36836" checksum="4DE38AC180DD0994" modified="2024-01-24" version="1">MQLPLALAAILSAAALVHAHIAAFTKGMWCINGSTGDNFNSDDPVLPLYQLEFDQWWMHAFNGCNQRPPNPGDFLTLPSGDSVVLELASNQAFTSLSYGGRLTSDWPNGQDYPDNNTNPSCITAPNCSHDSPLSFAAIFSNLRDYGSAHAKPVNGRGDCTRYIVSATYHIPDGLPPCPEGGCICGVSAFLLLKLYDPHVIVIPFLSLMHSVELDSEWVRSRHPDLFALLQWNFPDVVNQTCISQLVDARFPETPTAASGNNIEVSGYDLSGEPKSPAYNAKCGFADGAQNDIFDDDDLSISESTLIKKSLRPVGGANDSIGESYVERRRLRRARKNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW64</accession>
    <name>A0AA38MW64_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1057399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW64"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041377653" evidence="2">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="162" mass="17666" checksum="AFEBE3DF90680A5B" modified="2024-01-24" version="1">MMLVHGPILAILSLLLGLLSTPANAAPLSINPIVPRALHSHLQLRSQGSKNSPSPSPHVNGINGINGDARPTVNGINGTNGDTRPTYQIWFSRPRPETIERDPNVSHTIRSEVLSTLSQLEHSTNQSSFHITFLESCPESAQGFWYQAIGHDQSHYTDFAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWU3</accession>
    <name>A0AA38MWU3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DFJ43DRAFT_1147895</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">ET3784</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="JANVFO010000073">
        <property type="protein sequence ID" value="KAJ3717582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWU3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041256705" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="18"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="205"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ3717582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="473" mass="49915" checksum="BDF322CF5AA50110" modified="2024-01-24" version="1">MKLQTLSVLLAIAAAHASKINPLHIKRQATSSTATSATVAASSASSSSGTSAVSSSTSGTSTGTATGSTSAVAAPASATWGTSFPPLSQISSGMPSEVTQPVTTTYSPGTSPTYFSGLIPFPLLVLVFNAADWPAQDKLPDTSSSEVQEWMKELDGWDIPDLSPTVDGTCVSDPANVANASARGWWTCGGYTRDTDITVCPGKPMTWGTSFDDGPAFYTTKLLHFLNEQNIKATFFDVGSRCIENPSVLIDEYMSGHEIAVHTWSHPHLTTLTTAEIVAELGWTRKAIKTILGVTPTTMRPPYGDIDDRVRAISLAMGMVPIIWTRTPAGVSFDTFDWEIPGGVVTSEASFTQFEAILGNASTLDDGFIVLEHDLYEQTVDMAIGYTLPAALSHNPPFTLEPIGQCNGIPYTNMYVESNLNTSFPIANGTSDGGIDTDGDGTGDAKSKNGTSSATSSSNGAPLDMFLIQYTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX74</accession>
    <name>A0AA38MX74_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor IID, 18kD subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_990212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX74"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="351" mass="40083" checksum="D2205916F5FD2552" modified="2024-01-24" version="1">MASSKKTGEATSVTKDYKYTQEISQMMFVFGEVQDPLSETVNLVEDIVRSQLVELIIQARGLAVRRGVRYLSAEDLIFLIRHDRGKVNRLRTYLSWKDVRKHAKDSDNAAGGGGVEEALEDGADDKLAAKAQKITIKLPWEITTLYSEVLRQSGREDEDEEDEDDIEAHEASIQRLKEADDATRQMTREEYQHYADCRQATFTYRKAKRFREFLNLPSHLDLRSNDDTVDIVGFLAFEMVRSLTLAGLSVKKSLEEAYHRDDYSSPVLGKRKANGIGGSAEKRRREDSPDRDEYTMPVNSLFLPPPEARTALRPEHIQDAFSRMQGDWSHRRSAGIRNWRGGLVRTRVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXV2</accession>
    <name>A0AA38MXV2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_594619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="476"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3724991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="565" mass="64082" checksum="DE40C497FE03957C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYI1</accession>
    <name>A0AA38MYI1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_987169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYI1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="314" mass="35200" checksum="4C312687EF8BAB66" modified="2024-01-24" version="1">MATLTTTLTATSRARRFSLSLISAKPSPLLNLPAELVLDILESVLLEAKPSALSIISKLISRFVDIIIYRTVVLHSKESLTLFHRTTLSRSPAFFASHVKKLVVSYQPHNEVNYVRAQRAIAVCGGIRSLVLPMWFGTDCLASVMEGRTDGGLSEIIIQSPDGMIAPFECLHKNSQLADTISDSITHLRICEPGGGWTSPKEILHPFGALRNLTHLQLSRRANANSDNDLKFQEQVRSILQTRPALCVLAVVFYPQLWVADEDVRESDIWAMMREVAEHDGRLLLVQGKNDDWENQWRSTKSDAGRRFWAELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYK7</accession>
    <name>A0AA38MYK7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1002607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYK7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3725559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="59166" checksum="8D6DBED7555E0966" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYN5</accession>
    <name>A0AA38MYN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_465175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYN5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3730083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29841" checksum="68312E72A62FB12F" modified="2024-01-24" version="1">MTGRAAPPKDQWQYFPFTTDISINEDVKYKSFDEISILLFPVLILFNPSCTSSPNNMYSDSYYYTSNARHDTHFSNDPQVRRLSMGDTNHTFIEDHDWHENHYLGIQTPLSGTPTSMVDYSYHADTGHSWQLPLSARPTSGAPISHAISSPSNSQLSSLRELELSSRASAHVDDFDDPVPVPPLPPNATKEQKRTWTKKKNIRSAKLSRIRRLRYTKQLEEELEKLKQETERWRTRAETLRQLSIIHDIFYPPFAVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZH3</accession>
    <name>A0AA38MZH3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_467143</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1057"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="403"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1182"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1202"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1281"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1337"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1409"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1435"/>
            <end position="1444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3730100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1444" mass="160308" checksum="55BF923F914945B3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZT6</accession>
    <name>A0AA38MZT6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_332964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZT6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25153" checksum="75908A589926D62C" modified="2024-01-24" version="1">MLGGVTRMTVSLVLTGALSHVLPIMVGVMSAKWVGDALGEDGIYNVWIAMRQYPFIPPVDYNDRGRTAADAMRPFGTLVKIQEGHSTLKDIENLTNKYDFHGFPVVRGRDLIGYATRNKLLSFKFLGLHLSADTSNKKCRFSSPKQQLPSVENNIDLTACLENSILHLRKEVPQAVVVRMFQKMNLHQILFTHRGQLDGMLTKADVVALLAAHFPHTGALAVENER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZV3</accession>
    <name>A0AA38MZV3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1138787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZV3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="146" mass="16661" checksum="5D8EC61A0CB3ACB6" modified="2024-01-24" version="1">MKFNADVSSSRRKAHKAHFSAPSSIRRKIMSSALSKELRAKYSARSLPVRKDDEVRIVRGKYKGREGKVTQVYRKKWVIHVERVQRDKSNGATSPIGIHPSNVVITTIKLDKDRRAILDRKNLKAAGSTDVEMVDTILVCLWYRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N064</accession>
    <name>A0AA38N064_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_376452</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N064"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041236869" evidence="15">
        <location>
            <begin position="21"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3731657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="516" mass="58622" checksum="B4A176D358617042" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0C7</accession>
    <name>A0AA38N0C7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1079606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0C7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="511" mass="59063" checksum="C86793566293C997" modified="2024-01-24" version="1">MVDLPFDIWWKVFEILPPDARVHFRAVNRLFLEIARRVQYRYLVIDGYGKRTKRLMKTINSLSLGYHVQSLHIQPWAVSNLPSAKAYLGPGGRVSSVFDHLHSFFDSDFPTRRAEALVRERMRKQIRLVKETAGMLKFVQEYSLEWNVDRPYHPELFTAFLSLVDVSPFGQTLTKLSLKVPTDRLICLASVKLPALEQLDLQLVTMSLSERCINDCFDCFAVFVNNLCPTLSSLSVSSSHISLNLNLYRLFYLLGDFPHLRSLAVTIPYDGAHFSSLDSLQFFIRKHRQTLQELKLLCNRSAARTRPNDPCAKYWIQRTITDVCAFGNLTNLSSIELSLRPLRSELTPFLTFLASAANQLESLTLTDDALTPEEVERVLDAVTCRIPADSTNRNFAGYCNLGYLAIRLQYLCPYTVDLFASKLCLLRSLKLTFSDVRLHHRDEVQLSYTDYAYAYFEELRLFYAEMNSRWYPEWKLSSLAVSECPYRFEWGRDLEKVFTKCIPTLDSFQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0G6</accession>
    <name>A0AA38N0G6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_997892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0G6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3732047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31757" checksum="475FD72D47FC8DB3" modified="2024-01-24" version="1" fragment="single">MCFNHLLSSNQPADDLEIPAIQSALLDARKRLLSIEEKLIELELAEIEDELQQNDPEAQLLLLRDKQRTYIMKLQGTLSPLRRFPTEILSLIFTFALPSWVRKGVSIDPSSDIWRISQVCRLWRAILCEGMQHLWSSIELDCMGVNGNGQSLITTLLELALQRSGRRPLSIKFYFSHKNKLGVLPESEKRCLAVLANESFRWKEVELRYIPISALDSLSAAVKSHMPLLSRLVIENIPVSLAADTPSTAEAFQVAPKLQHFSLSGYFRPARFYLPWSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0V5</accession>
    <name>A0AA38N0V5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucanase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DFJ43DRAFT_223834</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0V5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041375703" description="Glucanase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="482"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ3733305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="519" mass="53813" checksum="F7E75CFBA3A92244" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1E8</accession>
    <name>A0AA38N1E8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1153896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1E8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="123" mass="13231" checksum="F2EF95D89BE7E608" modified="2024-01-24" version="1">MTRTARATYPRAALKDRSQSRSGMDKSLKKDGAGRGNWGKLGEVEYDDDDEYDEEVQEKVIENLDASEAGSEASSSSDLKHSISSEEEIEAARAFRKQAMSGSVDLSSIARTSVAVSGSPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1J2</accession>
    <name>A0AA38N1J2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1070528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="975"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1332" mass="145501" checksum="DA948F9CAF1FA643" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N246</accession>
    <name>A0AA38N246_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1151800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N246"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3734641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="226" mass="25961" checksum="B69DF49AE2E8BB1A" modified="2024-01-24" version="1">MGRSFSGNDFNRVGSKFGGGGVAGASETNVDRRERLRKLALETIDLAKDPYILRNHLGSLECRLCLTLHTNEGSYLAHTQGKKHQTNLARRAARDAKDTQLMIAPTQSTVQRKIFLKIGRPGYRVTKVRDIETGKEGMMVQVHLPQIKPGVIPRRRFMSAWEQKREPPNKAYQYLIVAAEPYETIAFRIPAREIEDESDDAGYWNWSHWDPDTKQYSFQFMFRLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N302</accession>
    <name>A0AA38N302_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-transferase family III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_816938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N302"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF6">
        <property type="entry name" value="L-CARNITINE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="449" mass="48728" checksum="C5CCF6177B108AC9" modified="2024-01-24" version="1">MAMFKHSRSLLATRRQLCRSISINQDADDLPLSGVRVLELGQLIAGPFAGQLLGQYGAEVIKVEAPKGGDPLRVWRELDVDGTSPWFRSIARNKRSVAIDLRKPEGRELVKRLAIKSDVVIENFKPGTLEKWGLGPEALHPYNPSLIFTRVSGYGQTGPWAPRPGYASVCEAESGFRYINGFPDPETGGLSGPPVRPNISLGDSVAGLHAAFGTVLALLARREKRKQGQNKGMTVDVSILESMLNLMEGVVPEYDRKGKIRGPSGSSVTGIVPTNAYPCLPDVESPTVPSYIVIGANGDSIYNRLMQVVERPDLTGPAYQQNHHRVERQEVIEKAISAWTTRHTAEEVIKAMTAAGVPVGRVVTVKDIVESEQMQARGAIKDVWVDGNGSGKAGWNLKMTGTFPVLEGCESQPKWAGPELGHHTEEVMTDELGLSPEEVSQLRSDGVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3E6</accession>
    <name>A0AA38N3E6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_127503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3E6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="61"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="380" mass="42631" checksum="3B9B24D374EEAB8D" modified="2024-01-24" version="1">MYPSIPYTFMQSTPSKRYRGTLHYRDYFYVGQSYASLSSIAQGQIYVEHLVPNTVTQKCPLIMIHGYGMTGAHWLTGSNNVSIGWADWFLAKGFEIYIIDEPSRGRSAHQVTVDGPLHTIDTVTMQQRLTAPAQYNLWPNAKLHTQWPGSGVAGDDFFDQFYASIMPSLSDPVELSEKTRDAGVKLLDLIDRPVIFMTHSQGSQFGWLLADARPSLVKAIVNLDPGGPPFFESAIFSSRTQVASSTAEEQIWRFTPARPYGLTEIPITYSPPITSPSELAQQVIDDSSPYFIHVQQAEPAHKLINLVNIPELVITAEASYHSMYDHCTVEFLRRAGVPVEHVKLEEVGIRGNGHMMFIEKNALEIVEKEVGPWIEKVIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N451</accession>
    <name>A0AA38N451_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1136562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N451"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="515" mass="57792" checksum="59684786B1CB4279" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4L9</accession>
    <name>A0AA38N4L9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1053729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4L9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3736143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="72030" checksum="B736AD85E78517EA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4V2</accession>
    <name>A0AA38N4V2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP11 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1129433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4V2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3736247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="302" mass="33778" checksum="973B19F28F18444C" modified="2024-01-24" version="1">MCQFSVYTNLHKISVPHSQGEDAKEQQEEEKRRIREANNQAIRARKEAIETESSAPQPAAASIPRKDGSPIKPLDSILNLSRIVSVNASQISALWTAYHASRSEGTGRGYLCATIPLESYEKMAAVATKYHSFVLPVPRPNPDVSLETPATTETPHEFFFMEWAFHESPSIPSAAEPDPFVPSTHTSQAAHGSVNPPNSTILFTPLQEFKMRNTFATPYLVLTHYTDLARTHGIVLLRGEITPGSGNDGRYLLSQEDAQILSMNVQKFYLWSEKGPESILSTFHEKPSEFDWQEMLKYSTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N503</accession>
    <name>A0AA38N503_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA protein C-terminal winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1128676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N503"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="1">
        <location>
            <begin position="336"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="499" mass="57375" checksum="A3AB3C9F82BD50FA" modified="2024-01-24" version="1">MNVLKPSIYHSIHQVEGALEQQVPVVHSNSQALLFIGGIAYLRWYKKNVLDKIELAFEPGYDPALEVAEHYHTRADTSSEKHMKRREQDQIDRIIHGEEVGHYYVLLGPKGAGKGTMIFDSMAAIQADGVAMCDAHPDLEVFRLRLGKALNYEYNEDSQTGLFQRRDPREGGAALDIERALNKLEKVALRVSRRRHKPLILIVNNVHYFNNDEAGRNMLLQLQQRAEAWAASGMLLTSLDDFWPFFVMRKVASRMHVFSISDLDTREALHACIRMRANVKKQIEHHDHDQIKEAVSIVGGRLSYLNKVGKFMVATSVDALEMSNSLLEIEKAWLLSQIGLIQDCDDDVMDEQKWSSCSWLLLQEFVKMRQEQEEERRLQSEKYGKDESPEFPMPSIPYHKCRQIMTRADFLEELDRVNIVSIDVNHNVRPDSMLILLAARQVVETEGFEEVLNSVRDRIDEIESLHRTRELTFKDVDKGDRIRLVVDKGGAELLESRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5R0</accession>
    <name>A0AA38N5R0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1176982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5R0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="334" mass="38842" checksum="16A6A3FB5FD58A3F" modified="2024-01-24" version="1">MLRALLYIPWKLWTLFPDSLRRRTYLYIAKNWGITHIWNVTRLPFGLALKRTHNRSPDIEANSIRFVRRNTTIPVPDVLDTVPPDGKNNSGLLLTSWIEGETLSSWIQRHLLWPAGFQKNADVILYSDSLEEQADALANLKTMFPEVNVPDDHTLLVELRDALTQIRSLPAPLSGPQICNINGGPTIWARCRDRCLLPPVNTIAEFHELLFQQVSWTSRLERLRLIAKPVHTRDYRITFTHSDLNPSNILVKDDHIVAVIDWEFAGWYPEYWEYTQLVMQNLHLRPREELWKRVGFFSGQYTEELKLERALWHSTGDMSIAPGIIPNDYLDQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5X2</accession>
    <name>A0AA38N5X2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1045811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="272"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1405" mass="157457" checksum="551124CFCC43BB99" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3I5</accession>
    <name>A0AA38J3I5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_889401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000095">
        <property type="protein sequence ID" value="KAJ3713973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3I5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3713973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36471" checksum="33FF365DFE6B8775" modified="2024-01-24" version="1">MSFPFALEPLPPPRPTSFEIMKELNDSRFKEFSDKRNAESAEVLYAQFAPPTPPRTSTRFNAQDAEITVISSDNVLFRLHKMNVQVTSGGLLQSKVDNDFLTLTEPADVLEILFEFLYPDYETDLERLEFTALLSVAEAAEKYGVFYAMSHCTFCLRKHTLFHSVELLRFAVRYRKEKMLAELTPTLLDIELDQVITILPPTAFGEFCLFRDRWVKVLLKCFALVIETSIEHDQNKSYPCSREPQTQITRRLKCFLDDAIAKPSSLFPEQLDRTFLQLEAILVGNGCTWCKDAFVTFKDCVLDQVKELPQTFAVELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4C1</accession>
    <name>A0AA38J4C1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_810032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4C1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="293"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3716281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1174" mass="129898" checksum="3BDD0B4CCC8FCB08" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4M0</accession>
    <name>A0AA38J4M0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1004458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4M0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3721388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="202" mass="22853" checksum="A49DAFE4AF48E393" modified="2024-01-24" version="1">MPRRQHAILGFRPAGFSPTLQDYHAYEVLRDDFLCSARGRAALLAGGIVARLARDAVNEQDVYDGPTENALQEGEHVLCVWEEGKHFALWDDNLTEEEIDLICGTYEVATGMDGIHQTAARSWWPRPGAWRSCGLNCGYWSRDAESWFQNRLNVIRAPGQSLALMTIPEWHSRLKFHKAHTLSKKNEGLALEYLKQKCGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J536</accession>
    <name>A0AA38J536_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 30 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1158437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J536"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041321995" evidence="5">
        <location>
            <begin position="26"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="6">
        <location>
            <begin position="72"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3722165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="481" mass="51850" checksum="D4663E16CD983C45" modified="2024-01-24" version="1">MFSNQFSFFFVAIASILSWMQLVHGQTISGIVTSSDQSQLLQAITDAPSFTSGSGAADIAIDETTVYQQMVGFGGSITDSAALAMHNLKNANADMYNKFLKNAFTSTGAALSYLRVPIGASDFSSSSYSLDDISGDTSFNSFNISNAPSYLFSTLADIYAVNPNVKIHILPWSPPAWMKDGNTMNGGSLKSGMVSPYPTYLLKAVQGFKAKNLPVEAISIQNEPQNSNPTYPSCTIDASTQATIAKSLRSLLDQNSLTDVKIIGYEHNWDDTSSYTIPMVDDAPNAFEGVAFHCYGGQVSQTAAFSAQFPNIPMYQTECAGTPGSDWWTDVQWYVNNLWSANNTATGMMWIFASADNGQSPYPGSNSCGDGCRGMSTVTTSSVTYNQEYYSMAHYARAFTSDDGSTLGKRIQASGGSNLNVVAYATGDKYSLVVLNSGGSSKKSISFQGKQATFTFPSGLTTLWWTGSNTSTKRMIKKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5P0</accession>
    <name>A0AA38J5P0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1092105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000053">
        <property type="protein sequence ID" value="KAJ3723507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5P0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3723507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="454" mass="50994" checksum="BDD97F44E487AF21" modified="2024-01-24" version="1">MSKSEAHKLKKSLQPSRKGKKAWRKNVDLNDLEEGLEERREEERLFGGALSEKSDSALFLIDTEGDENLRSVLPKPKIPQLTSLKILSERSAVPAVYSRTTSAPTRKHGLSREEKDRLLKVAKRSRRGPFGAIVDDRDGWSTGAAASGGVSEAVKLSGQYDPWASPPPSVYESIPLPIANLPPSHAHPRSTASAISNNPRSLIFLPAVPLPHAGTSYNPPVEAHTELLHRAYTEEEVRLREDTRWKDVGQAIKDAVAAQPSLNTGAEGMTHDDPEVDERNVDVEEDEAVEENIPSTRVSQRKTKAERRKAAKLLAEKRVLAERAAKRRQLSYLSELNAKRSKRMGLAPAPRELVQRRRKVLQEKLKAGLAGQKFGKYRVPGTPVDVQVGDELSESLRGMKVEGNLFKDRFLNLQQRALIEPRLRVLPKKRRVRMVEYEKHAWKKFDREQEALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6T1</accession>
    <name>A0AA38J6T1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1084927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6T1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="83" mass="9431" checksum="4BEE87D4C763F136" modified="2024-01-24" version="1">MYEGTPFPFTYYFLPSFSSFSYLLSISIVLYPPSSGALQQYPTIIVPLPHLLATLLPSLLLSTYTKNKNLYHKADIVYTCVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J747</accession>
    <name>A0AA38J747_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1132842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J747"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3729939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="628" mass="71509" checksum="F144AB8CC32B86D1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7H3</accession>
    <name>A0AA38J7H3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000089">
        <property type="protein sequence ID" value="KAJ3714644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7H3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="367" mass="41124" checksum="C18BB8CF69E3FD8E" modified="2024-01-24" version="1">MKKQGSLSALPLRIRIPGGADSVQAGVPTDEPLKGKRKRNTDKYIAALEELKDDLPSKAKKTKATTRRGKPKIKRGGGTGNNGSADEGDDKSRMKSLVNQISRLTRNLPKSIPEGAPNGKIAVSLDEEGESGWAVFNKFFDRTFGEDTRNSSGRLQHLTRGEHGMNFVNRYLVSVVDNYLEDPQFPVDLAVGKLMRLCDELRILAGAVNQEDDHGEEDSCEDEDDGDYFYHSRTRSPSLEVGDVMYNSNGEEIVDEDDAGPSSHRNVAPSESEEETMDRKVKTRAKADKGKENWVAFKSSSRKVRMSREDMDVSSEEESDGQSALRKIEEVERIQRGPKSNTRDFWTERLVTEKGKLRWEFKCKCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7P1</accession>
    <name>A0AA38J7P1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1156093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7P1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3730972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="475" mass="54153" checksum="259FB6484D8A9CDC" modified="2024-01-24" version="1">MSGSSSIMPRPGSRDAPKLTAEGTDDPMKVRRYFDDLENLFSDCNITSDEDRKKWTVRYPEEQVAWEWKAMTEFSSSLKNFLEFKKAVLSSYPGATDEERGTMRELNRLFKKYKNIASDDLDEYMALVRRFRAVKKELNPPAVIGAIVQPEPLVTNRELVEKFTRALDLGFRNAIFAALHIKGKTRTVPIGQKVRPDDMYDIDDVVTQGEAIARGTMPGTDPMSSVATHASTSSASHGQVKQEQFQQQIQDLISEKIAVLMDTMKISQDQLRQESTKQMNDFMRIYQQSNVTRNAVGFESNHTKSQNADMRENNKVPYEWHGNLSKVVCYFCSEEGHVASECHHRQDLLELGRIVLVNGRARLPGNYPIPRQPVGAVSEKDRIDFYYAEKERKEKEGVRNVNMVQSTPNNIPGMINSATMSTYLNNQLSDKEMRIANLEKELQSLSTPSSQMMYQMPGQMNQFVQQPFQCLSKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J840</accession>
    <name>A0AA38J840_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1155975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J840"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18785">
        <property type="entry name" value="SF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3730856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="391" mass="44436" checksum="9DB1E49991E76264" modified="2024-01-24" version="1">MTVCLFLGLKEGEYHSIKRSNQRHDIQLIVREISSPADGTRFRELDWVLERKRNTIVFCRTIRLGAQVLGYFHHKDKQMGGDPRTVLQRLRQYDSLSKEYNEVTRNLMRSQMCQVVIATSTLAVGIDLEGIEDVVIYGDPEDLDQMVQMIGRIRPEYRESAVTRQGIVYFSANARKRAEESLAKHRMMTTLDDKPSIMDLGLAQFYLAQCKVEDLDRQYENSDSDVQCSCKTCIEIPPPSAHVPCLCSGCSPETISTASSPSKPVNTASGLALPAKHKRLTKPMRVHGARELKKFRLELFNAADPRSSGMLSPFFYFADDEIQLVLDHFASITTPEVVHELISKNKRLRPHSQQLFERIMGLGLEFKEIQKAEKQRKDEEKAAKVAGQSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J860</accession>
    <name>A0AA38J860_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1027594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J860"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="131" mass="15017" checksum="48F1FFEE61549F64" modified="2024-01-24" version="1" fragment="single">MAVTWESYFTEEHVGTKSGTSEFMSSALLDPLNKNYVHSPVDDYYSLYFVTQWACAFRDPNKELQHIQQLRMRLAGGLDSRDAATSTTITGTKLKAEEYGAFLVQAQPFLRKWYGSLQSLDNEWREMDASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8Y0</accession>
    <name>A0AA38J8Y0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_755470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8Y0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="242"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3718566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="402" mass="46346" checksum="D6EB313060D8C978" modified="2024-01-24" version="1">MLIDEYRPHAFFYLRSVNDLSVPWVPSPFTPARQLPPSKVGSPVSLLSSTSTTLSSKSPPRRTKKTLQFHLEESQTSPTSDVGTRASERRKHRHLSFLRSVRKQLKSRKMAPKVLEVEIEQYDPAELEPSASATPPIPLSEWKAWSYYARPCVNGVDVDNLSPKPKLDVELDIQMMFDHIKSPGGTPHPERWIKGQKHPALPPRPATWKRVDPLAPLPFPWEIQLNPLLTHSLITYPEYTPIYWNLTLRTSLLFFLTEDGGLQFVMDNDVCQPASCPLVTHMYICAYAFAPDWNVQYRLPWPIMLQSRDGITCEDFFDGLYENFGQHLKKSEYEKWDEDMQRYAMQSHIKHPRGWAEDDLMKRSDILGDNIFYRGLAPSLNMEGWVLLLGPEPPMMIKENPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J951</accession>
    <name>A0AA38J951_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1098960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J951"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="3">
        <location>
            <begin position="158"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3717605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="502" mass="54403" checksum="DEA107967E5C565E" modified="2024-01-24" version="1">MQVGTSPQTTLYQLHQQGYVPNSAADDYERKRRYLSLLPPPQVIEICLSFDIHIPASVKTAIWPSDLDEAINTLQKASGGKSVPPSTPSYSSVDTNPEPLVHPEAPNTATEVPGFLVFVLTSSIWCPQPYGPTQPYAPPPLPIHRQQPHYQETQSSDEMPSYEDMIVEALNDVRDPEGLAPKDIYSWMVDHYRVQANFRPSASQALQKAYKRGRFEKSLTGKYRLNPHWKGGNTTRRTTRRPQSHSNSLPPPPPHTRHPSFPNSQLNHANKMPAFLQPSYMLSYPPTAGQQSHLPEDDPAGDIGDAFEAAQHILKALNFSGDLLKSSHGPKEDSTPAPPISLLELATENVADTSVEVEMNADGVRAELQAQLLLLAAQLSEIASISSEATDADSSASTMIASAIEALAPPPVGGGSSPFTGDTLSLFTSSATIPTSEQVNLEISLEGKLSQAARLEAQQEEVSGFGSITPSSPLAPTSTAELITMNNVDDDSDDEDMDEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J981</accession>
    <name>A0AA38J981_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1224626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J981"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="369" mass="39908" checksum="76C4B746BC565BB7" modified="2024-01-24" version="1">MATSPRNSESSAHSSVASPTTMSSISVSENLQTPPFPSSPTPSAAKARPDIDHRASTLRASVFDVFAELGAFDENSQIAEWIFNPNVDDAAFASSSAGPRKVNVHFLEKSGSRFRERLNSDGSANLLNGYTSRVKPFASSPSPSTSPMPTRRPPMRFFNGLRARSASRNRRDKRRSPEETIVEEPITTVSPSKKRPFLQYLPRPGYLGEMRSASSPVTVVLGHTSSPSIATNASWEHIQGSASLDLLRSTDISPVNTFLHGKHSPAPGIPFPSQRESGGGSLFLKKISTAVARPFSAASTNHPDTDTSVMKRASYQINPIRRTRSRPPEATETLKVTPLRTKFPSSFSSPSSPTDVSPTTRALATMDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9C6</accession>
    <name>A0AA38J9C6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1008911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000119">
        <property type="protein sequence ID" value="KAJ3711442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9C6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="190"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="558" mass="63834" checksum="8098F2CF3D983F32" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9U0</accession>
    <name>A0AA38J9U0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1006704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9U0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="158"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3716716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="596" mass="66522" checksum="C2D4E217FC7CCEF6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB43</accession>
    <name>A0AA38JB43_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1155354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB43"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="79"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3731679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="542" mass="60271" checksum="86ABBF0A34D8D0E5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBS9</accession>
    <name>A0AA38JBS9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_970257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBS9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32732" checksum="6BF1E31299FA3FD2" modified="2024-01-24" version="1" fragment="single">ESMIFRDMMELPVSLQPEGSTDENPICLESVLEDDFRQLLRILAPPYREPVPVLTFSEWTSMLKLADMWCMDVVKEHAILTMSGLSGIDPVDKVVVGRKYRIKNWLLPAFNVILQRSQSFTEYDLERLGTLFRFPINLLAKESEVFRDMMEIPAPAQAEGLTDENPIRLDGVLHDDFVKLLTILAPPQRFKEPVPTLSFSEWTSVLKLADMWCMDVVKEHAIATMNQISKVDPIDKVVVARKYGVNSWLVPSFDALLRRSQPWDEQDVERLGLSTVLKLVELRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCB1</accession>
    <name>A0AA38JCB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_153040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1459" mass="152700" checksum="FD9BE9ED1C9831AF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCH5</accession>
    <name>A0AA38JCH5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PWI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1001436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCH5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="42"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3728064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="215" mass="24613" checksum="21C39B7238AC1DDE" modified="2024-01-24" version="1" fragment="single">MVSLCCCAHKISFCLPFSGFFKGTSADQDRRFSDKELKLLKSMKFPPEFDKKVDMRKVNLTVIRPWIAKKVVELVGFEDEVVVEYAMGLLEDKQEPTPDPKKMQINLTGFLTKDTPAFMSALWKLLLEAQSDMTGVPRTFVEEKKEELRRARERDSRAIDERDRRARLDEVRDEDRGGRGGRGRGRGRGRGRGRGFDDNRGGRRDNGWGGRGSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCK9</accession>
    <name>A0AA38JCK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1065794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCK9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="351"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3734036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="602" mass="67827" checksum="A87523173D033CFC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCR3</accession>
    <name>A0AA38JCR3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DFJ43DRAFT_1109043</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000141">
        <property type="protein sequence ID" value="KAJ3710337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCR3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001330">
        <property type="entry name" value="Mitochondrial Rho GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="415"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ3710337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="645" mass="72231" checksum="3714DFB744C70C52" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDA4</accession>
    <name>A0AA38JDA4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_481592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDA4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="370" mass="40436" checksum="9052EF416DE3176B" modified="2024-01-24" version="1">MLDAFKLKPYDLEPVYASWPDAPMFYGSLPNDGKHPKKAKDMPVDEWLRVIKEGCVERNVPKEYWHKVAQHYMGEKAKGRLDELKAVMAKVHGGNYRWNWEKFKIAMRNMGWNVDASETESIKVQGKPSGLWWMPHHSSKKDEPQCESPTEKTSSNPLHDAADAASEKGGNSFWITRRPTFDSLDKKEKPEKDSSESNPPQRKRPQRSATSGSTLSLQWPVRRCSKDEFEVKPDPMAVSAPRPSPQKAASDSLLTATRSMTSPIIIPGQSSDETITTVTHAPIWLLNACNALDFLSTEHPKVMSSLSAILITAGTIPSIPAISAGAGGALLASGAVQAVGAIALGVGSWLKAAHQESQARNGAGTSGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDA8</accession>
    <name>A0AA38JDA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_595041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDA8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="301" mass="34207" checksum="8D43E5DD04F19D26" modified="2024-01-24" version="1">MDSPPIELYSEGFRCAPARSNGDVDLEEGIEETAGYRGWVILVDEVKKDWNKRITSIWFQTFCCLLVLHPAFCVLGELSWLYIFESVSLSDLRNLVRPPYGISRFMSSATTLRILRAFYEKSMLELCIFLALVLLLTLFVKTLRKRVNICALICSQVIVDHAKMDLEALGFSAQSTCIADAEDIFLQLLQSFDVPQHSQTRIDPQRYIIPARASGMINNRTLYNPSFFVFFHCPLIAIACFIKFSISTLPPGTFLFSLIFGVIYILALLAVVAVWSFFAFHRLPTAEDIWGHFVMDLNSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDD7</accession>
    <name>A0AA38JDD7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nonribosomal peptide synthetase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1158508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDD7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109542" checksum="FACEE86C8F6141A3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF81</accession>
    <name>A0AA38JF81_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1007917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000093">
        <property type="protein sequence ID" value="KAJ3714002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF81"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="439" mass="49957" checksum="A4B71895D0E85147" modified="2024-01-24" version="1">MATASESTRLLSIPAELIHHILAFCLPTDVANFSKICRLSFDLVYSGNDQFLWRELFLNNYDDPRKAIRTLTLDEVSFLKPFDWKYELQSRTEAEIIARHALRAEPNERQRVLETFISAALQALPTSRTTEDQPSLNLQWLDRVLRETRMLTQLQTETQAHSRLRAYISLSHDPSTDEDSRKAVAARRIDSRCFVYDIRNYRNVNYWGPFLANGSVNWTHVEHLANVVLTNLRELPGSWAATVPPSGLENTRAFSAPGPYSDTDWAGVEGTWRRYVCFMDYRDLFAFNYSNVAHGPRNPEFFRDIRFREATRLIEIKLHLVQQSQLCFHEPSPDCENVKTRYPTLYFCGTSRGVSGNEAKVEGSVCIGIDGTVRWTFVSAYVGIHGMISSKGVQLGSIASAAGIVGSWSTSVHDQGACWCPFWLWKVPHAYAGPLRDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFI9</accession>
    <name>A0AA38JFI9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_698073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFI9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45296">
        <property type="entry name" value="TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45296:SF1">
        <property type="entry name" value="TRANSDUCIN_WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3736087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="358" mass="38697" checksum="C151B6A069E34B32" modified="2024-01-24" version="1">MNRPCPYFVVKTLNTPAPISSLEFGHAGHLFAGSDDGTLRVYDLSSFKVLKAIRGLKNEISSIACFKRAGSEIRDAWVACGNQIFLFKMDMPSMIGTAEDAITVVKLVEDDDVLNEIALDPSKKYLAFSTDSGLVGAIDLTTTSPAVTKMKEKHGSICACVKFVPDRPREIVSAGYDETFLHFDFLEGVPLSQHRISFSQNTEGVSLSPPFIMSTAFSSTGILAAGIADGSLWIGLGGQKGLSKTKSKRTRKWNGLSDAEKRICIKVVEGPIVAMSFSSPDTLIASTLLGSVIQWKINGESINQENIVEEVWRKQTSALEKVNALITIDSKIAIGGFSKNGKGSIEIWDRRGIAGPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFK9</accession>
    <name>A0AA38JFK9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_478179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFK9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="552"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3730019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114297" checksum="D6A11C8757E5135C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG77</accession>
    <name>A0AA38JG77_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1000579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG77"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3729990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="302" mass="33658" checksum="85C24C0960606D05" modified="2024-01-24" version="1">MTSTPRNAEFAHLFDLFEKLASRRSRATDVVEHPVMDDTHTFSIPTDLQPVFRNLATLVTPRTTSAGTRKGRRNTVAVPFGSSDIDTDCESVAQFPIGKQYPFKFKMMLHKLYELEDWGKKVREVLEMSQEKFKPLADTKNSPKSGVKEREDNGTAVAEFGVRPPPKRTGRPRSNTVGPGKEVAPRALGSMARVEPRDDERAVKKRCVGRRKSMSGMAGESSTWVFNATVASSEINQRVDIPAPATVTRYGALQQDGRRRVPPRRRVSSVASVASVIDGRQSIDERSFRKRRATSVAVVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGI5</accession>
    <name>A0AA38JGI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1156722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000039">
        <property type="protein sequence ID" value="KAJ3728155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGI5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TEA" evidence="4">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="2">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3728155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="613" mass="69260" checksum="ED4294A870A8FB5F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGQ7</accession>
    <name>A0AA38JGQ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1150243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGQ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="160" mass="17595" checksum="9C2E21C615B43664" modified="2024-01-24" version="1">MKIEWASDFHRDGSRRSRPIASTMHGWLAKMRGTLIGNEELRSRGMREMKDAKAYRRHRKVAKSKGKSSGQGFSLFGRKPTPQRTNSGNVTRGHHGGGGGSRPALRQHGSGSHRLVGQTPRRGSGTQSRGSKTPARPGPSRRTTTTSQRRGTTTRRPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGT5</accession>
    <name>A0AA38JGT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_989107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGT5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="1">
        <location>
            <begin position="69"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="248" mass="27729" checksum="13EA1CBA5D73FD57" modified="2024-01-24" version="1">MFSAAVQSGLVSLFSSTGSNQLQLFSTHCDESLPSDAYIGLLNDRSSEPQPSGTVSLISPHSEQSGFLLDQTVLHIQSPVPPKTYIQCPAQSGVELGLKHPWIHLQVRNLGREWSFEVGIADRVGRKGIIRFSTFQKQPRLKVPAKSDDLPLLHLPLSFPSDSTQLTAWSTINLHLPTFLPHFINTNLAEHEESIDDLSHAQVSIPSGQYSHISHVRIYSTCRIRRIWLSDGGPTQKLPWEFELYARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGT7</accession>
    <name>A0AA38JGT7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1081194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGT7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="652" mass="72716" checksum="01B93AB894479A10" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGW5</accession>
    <name>A0AA38JGW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_990967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47728" checksum="C85775660FB91918" modified="2024-01-24" version="1">MKSASSYNRLRAQVLLLAIVVALYLLYSNYSSTNSNDNSTPPYSLYADLNQKEEEIGQKFLESLELIETQKNPKFVLFRQHEGTDFGNQTQEILLHHHLALQSSRFYIYQPFYWKSRNEQLPLSAFLLGASQERAVPASFVEKLCPKGSDDVAHIKIQSTQEDLWNTALSALKRKEKCIIMDNPIIDTAYLSSPTAESIWPLFQKHLARWFQWSPQILDIVERTQAQLNLRRQFSNLHGEPYIALHLHRKEFLEHCKTAAQQHLGFMNWANLPAVLSTTLPPRLNPGNDSSVMEHCSPSLSRVMDAIDRQVRRKPYLRSVHIIHDGVASTDLRKLENALKNPGRAQRAGWTYGPIKSLTHSAMVPHEPEEVDFLVGADVELARRAEVFIGNGYSSLSSYIVALRMAGDLVVAGIPEAITLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHE9</accession>
    <name>A0AA38JHE9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1037080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHE9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="200" mass="22406" checksum="31A6CE004776AE36" modified="2024-01-24" version="1">MSYLIAGVEEQEITNWEVMMLDPRGGTRCFANYHVTPEYTSYYEVVHCGGGDAIYWSGRDLFVCRQSAHTSSTSVRPNSQGTALAECVFHPSSRSLETRIVEIWYNRFLLEDLCVPPQNQKLDLIVKKERHTGDETTTFGIFSSSPSVLPTNTFVLTPSSSRSISRSGKATLATEFESSSDADIERGVGRIEGIEENYWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHL6</accession>
    <name>A0AA38JHL6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gpi1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1048960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHL6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54800" checksum="F43BF9424E6A7B4B" modified="2024-01-24" version="1">MANDPTEETPLLQDEYAGSLPFLRDFLLRLESISLEDLNQNDLLFPSQLSIHRALRASFSLLVLLLFREKKTQKKTVQYNPWDDWKDEALTDQWIQTIDENIELLWTTFLGEFCSSQDIELILWIEFRIDKKGKPLRVIDFVSKQPKLLNDRVVELSLLYRWKRGAPLNPSTSSQYLTPRYDALCTPWIYHAFDLASQIVFLLLLVSYVLNPPRPAFYSLPLEYIGSREIVLLVLSVSAILHSWTTSMPFALTLLAFVFKLPSAPFPSDFAFNILLLSIALLLVQLHLPFSPSPFLLFWPERSLPLAVLIVNGILGTTLKVLMFFLPVLLLSILFLSYALSDVFLLSSFAHGPAPMPTRELFFILAIFTFISMVLSVLILVPIFPTPARKSASWDQYSVSIGHKARVQFYHSVIRYSKPYPFPPPFNILYFVLILVPAHALPYFDISISFLFVLQKILWRVVVGPFVVIVRLLALKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHN9</accession>
    <name>A0AA38JHN9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1151508</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHN9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3735339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="190" mass="21012" checksum="0B4F79A93D029523" modified="2024-01-24" version="1">MPSLTTTRTIAASRAAASPYPHSRSCLLTTSGSSDTDEEVETTRGRSYRRKANISLTATRRSARLQAKALPTQAEYEEMKEKAELAQQELLKLEIIRTELFTCPVCLDFAYQPQITQCGHLYCATCLNGIRVHSIETQGLFTQCGLCRGDLYLPPVPCRPLQDLIESIATTDGLAIPGYVSEVWVGRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHV0</accession>
    <name>A0AA38JHV0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1041884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHV0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3723547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="107" mass="11600" checksum="44A4A703CD6FD0DB" modified="2024-01-24" version="1">MRFSLHLGIFAGVSVALCSAVPVSQTISINDQAYSLRLKIGAEFRTAMRSRGVELEDVAFGTKEYYHVPKVKGPSNVNAMLILNYTSRKLASVVTGAVSFGQRTSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI44</accession>
    <name>A0AA38JI44_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_245876</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI44"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="160"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3733264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="390" mass="42820" checksum="12603B03EE976284" modified="2024-01-24" version="1">MATIPPPLGNIDRESALLIARLALGDIDDLRGGTAIPDQQYALELMAQDFAQVLSYLNNIEVDNQHIDHRSHSPDNDSDAGSSSSLSPSDVLQIDDESYLIEFNNEPAASSSGLLMSGISQTDDGNVELPPIRHTPSSVSDLEHPPQASSSSTGYPLVEPVPACVICMESHDDDSVYRVQTCEHYYCASCLAHYVETCINDESLFPPKCCGRTLNFTLEKESGSSPVEDLVGFLEVSEIDGDLSARLRAKASELKVSLEDRVYCPYPRCSKFLGSWASLKSIYGVPETSFPFRDSSHPVPPRILCTSCLKYLCVLCKGPAHVHLTCPVIDEQLADDKLRDLAREKKWQTCPKCKAIIELTQGCNHIVCRCGSEFCYNCGSVWTSVCVCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ17</accession>
    <name>A0AA38JJ17_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ17"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="120" mass="13972" checksum="AA94124D49C84495" modified="2024-01-24" version="1">MRVIIHKVANTYQFCEGCKYKRLQAITWAHRGSFVTIHVYGVSNCWFVQLVKVKFGLNDVLKKLEDVAEVDFPMCTENIVQEMATLVTRMEILEEVLKQVVREVERLKRIQAALQNEDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJC4</accession>
    <name>A0AA38JJC4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_712815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000060">
        <property type="protein sequence ID" value="KAJ3720790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJC4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041316729" evidence="2">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3720790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="114" mass="12033" checksum="9CBE88E4422D0B6B" modified="2024-01-24" version="1">MRANSVLAIVMFMLSAMLCGHSQAAPVELFEGTTGRRSGTNEGSAADWRRSGTSDSGSAADWRRSGTNEGSAADWRRSGTNEGSAADWRRSGTNEGSAADWKRSGTNEGSAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK53</accession>
    <name>A0AA38JK53_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_383710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK53"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="337"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3736884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="742" mass="82031" checksum="3263DED01112552B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JK94</accession>
    <name>A0AA38JK94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1181506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JK94"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="350" mass="39646" checksum="F20907121E064F44" modified="2024-01-24" version="1">MTYQPKHSAGRVSDMLHTLRGEQFRHSQNLNRSHGSLNLLNAPESLTERFINLDYSSSETSTTTPLVTQRQTSASRNFHGVSGPPPPKSWQNYSVSGDDSRSSATWRAEALSLIFHERPSTQKFTLNGISSLTQLCLARLLPELTDPEFIEYIATCLPVHLRLELVRYAAIHHPLSKSKLRALLGSEGHANGELLLCGPSASIHHDHFLQFSTQAQKREQWDSEDHSTSYPLHTLIVLSTRLSMSTVSAFPPTITHLALINLENSISLHRLPSLCPSLVVLELSYNIWLTHMSVDTLKSIDRVDWGRWTQLQVLGWRECFIPDGMLTRLNEGRWDDVEVVTDDRYVKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKU5</accession>
    <name>A0AA38JKU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hook C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_260414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKU5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41417" checksum="782EC767C5F047A5" modified="2024-01-24" version="1">MGLGGELHDAESGTTMTDLKLQIRKLKRELEAVRKNEADASRVLVLENLLDDANRMKSRYEADYLAAHREKLVLQRDLEEIRSGKSMGDGAEAAIALRQRLNESVEQLDTIRKEHAELEVKFEAQSKELTVAKSDLTLVNKDQLDILASLRDSVNEDKAGLEADLERLQKQNKELAEKNRMQLEQVNALLLEKVNLQSEGIGQREKMLQRERDFGDLRASLSGKDLPEDTKQRLLALHEDNVMLKESLKTTNEKLTKAKAFIKNQDKLYREEQAGKGVTNTSGMFEEAEVSMRSQIKILEDELERQNVLLAETKKRYMREAELLMSYIHSMGMNTMRGHLGQRPGKTAWLTSQRSNSRLQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLA2</accession>
    <name>A0AA38JLA2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_998809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLA2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF66">
        <property type="entry name" value="HISKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="379"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="825"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="725"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3731586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="944" mass="104775" checksum="B744449159F9D969" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLB5</accession>
    <name>A0AA38JLB5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphosulfolactate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1132349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLB5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36526" checksum="A4B915B8D32121B0" modified="2024-01-24" version="1">MPGESASAIRALRIVAYVLLAKSGVIRQQSRAEKMATDLTLNKTSYNFLPSNFLPAKPRSHGLTEIRGPYYYPVTQTYLDELLSDWGEFVDGVKFAGGAFSLMPEERLRGLIETAHKHNVYVSTGGYIEKVLSSSNGNRAVIQKYLETCKNMGFDVLEISSGFLSIPTDDWADLVEMTAKAGLKPKPEVGIQWGAGGDASVAELESAGTRDPKWLIDRAKTFLEAGAYMIMIESEGITENVRSWRTDVISSVTSALPKDKIMRAFPNSLFEAADPEVFAYHIQNQGATANLFVDHSQIVQLACLRKGIWGTGSTFGKIVTIGEGESGGSNRIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLH4</accession>
    <name>A0AA38JLH4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="4 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DFJ43DRAFT_1069880</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Chromosome</location>
            <location evidence="16">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 16"/>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="19">
        <location>
            <begin position="1974"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="2675"/>
            <end position="2993"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="20">
        <location>
            <begin position="3013"/>
            <end position="3045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3733213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="3045" mass="344027" checksum="1ABA3001E141F3B5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLK3</accession>
    <name>A0AA38JLK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1144487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLK3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="113"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3734749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="473" mass="55186" checksum="60EE1B37DF6D2250" modified="2024-01-24" version="1">MLSNGFIRNHAIEITADSGISRFQYYARSKVVESEAFRIVNEEWKKLFMAMVCQLNQLSSEKLGFIPNLHLDDFVYLRDPEQFAHDFKHDPEGLVGATYRFKCSDGYTRLFVIKRVLYRAEGIIGRASVVVEVECVCNESGCQWHGERKVMKISFPSRRRPSEDALIREARSKAESTGDPWALNHLPQIIDSITITYDESTVQDRLKTHLNEKYEERVMRVTILEKLHPLSELIDPRDFAQVFYDILQIHQWLYECVGILHRDLSSGNIMFRRKDGKICGVLNDFDLSSRVRNMDKGPTSNHRTGTRPFMSIDLLDPDWKGGHLYRHDIESLFYIMLCLACRYERPNVPTPEPRAYAVWFSGTDQQVLDNKTAFLTRPCTKAIPIQPYFAGFKRWLKRIRKKLHIGYIRRPVYLPEESGIDSDDDESPDSDEDPNFDWDTLNKRASYTTMRSIMSSFQGKSLETRWANWNRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLL3</accession>
    <name>A0AA38JLL3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_160757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLL3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="416" mass="44988" checksum="D52B3818E95205A6" modified="2024-01-24" version="1">MIVDKMKDTEEAPPAYEAASTSSSRSAPFPVYNDSKIPPSTPSPVSPPISPSSPSFSAKGKGKAPTLNSWWSFGSSQTAREIRTTVLGIVRDLVKVKSGNAVAAKGILESCAEACSGYSLSLSSLLQEKSIESHIPLYWAIINRPPDKSDEAINGTSDLLTTLLSYTAPLSPTILAEVRQACLITDDQLLFQRLRLSPEFASLSGTDEMLIGESMIPDDVTVENLLGDEGAFAVNFRIPHFQKRMRVSSEVAVEFIARGRLWRLALCVADRRRSRHGGPSPGAWCIVLSLMENSSPTWIDSRLLIPDVSSNVSAEEVDLISNDPPPPPSMFSGILGDRSKKAAISMRIQSKLELCSSQTRPNHNRQTEIVVPLDTVPLASSIQHAGSSFIGADESLSGRLEARLRKPQGDAECIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLQ6</accession>
    <name>A0AA38JLQ6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_996759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000022">
        <property type="protein sequence ID" value="KAJ3732665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLQ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="140" mass="16273" checksum="DFA7FA9F13179A0A" modified="2024-01-24" version="1">MLVVDPSSSRCDICLDPFEWNSTDRTPHIINCGHVFCAECLHQVFPTRCPLCRELFEPSEVRKLYVEPIEVRKLYVEPSEIRKLHVESCSDDDKEEVILLKQLISVHDSSEEEILRLRIRVDTWLAARTLDEVCADSEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JME0</accession>
    <name>A0AA38JME0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1068040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JME0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="242" mass="25507" checksum="AD32E66C9D36817A" modified="2024-01-24" version="1">MVTLSSYIIYDLKPKSPEFCSVLRFAISMSLAGKDGIFARQASAISIDGSVTDLPAETPGLQATTTSEPEAVSVTGPVTMLPLESPGLQSGSLSSDVFTLSTPVLGLPSIKAESSTTSSSNHGGAIAGGVVAAIIVAVIAATLLLRYRNKSSPRHWRNRIKGGAAGPLYHKSRWQNLESKSDAAHDELESGIQSGRSNIVLDDHNSPSTSPVTAKFSTPLITYPPSVSRPANDEKLPQLMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNU2</accession>
    <name>A0AA38JNU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1066914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNU2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF2">
        <property type="entry name" value="HISTIDINE-SPECIFIC METHYLTRANSFERASE SAM-DEPENDENT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="1">
        <location>
            <begin position="179"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="1">
        <location>
            <begin position="320"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="400" mass="45055" checksum="9FF9AF80485F858A" modified="2024-01-24" version="1">MLTSFVHRVQRGIDPHVDDPDHCHNHSVVPEADSDWPSLSTIIQFRDGVRSRLENLYAELDSGKRVLSRRIARMLCMCIEHEGWHVETLLYMLIQRSPGALPSNLPTTLPPPGFVSPPWDILAAQWDSTWESFSVLGSDSDSEARTTMLGPAEIVLGHDDSEADDYHFDGHNTDEVLNHEYGWDNESPARAIKVGKFKVEWRPVSNGEFAQYWCRNQGKVPAPKSWILHGDEATGEIEIEVRTIYGPVPLRIAHTWPVLTAYDDLEAYAKSKGGRMPTEGELRLFLDTYEVGYEGGGDSGFRNWHPVCPTTGPNSPSGKGTNGGVWEWTSTPFQGHEGFVGTNLFTGYSEDFWDGKHQVVLGASYATIPRLSSRKTVRNFWQHNYPYAWVGGRVVYDMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPH9</accession>
    <name>A0AA38JPH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1131077</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPH9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3734105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="380" mass="39430" checksum="8CF4DEC6007D73BE" modified="2024-01-24" version="1">MGSPPKPWERSGVAPTPSTPSLPASTPSTSSTPISVANSNSSSSSSYIPERPANSPSTAITSALATSNPSPYSYGASPYSRLGTYGGYGSYGGGLSNYGGFGGYGGMGTYGGIGGLGGYGGYGGLGMGYGAGMYGGGYGGMMGPNGAPVDVNGNPLPPSLTQTLEHTTQHTFALLHSIVQTFSGVAQMLESTFMATHSSFFAMVGVVDQFGHLRNALGSVLGLFGLVRWMKELLTGKKSSSGGLPGEFRQFADGRPKPLIIFLLAIFGIPYAMNKLIKILASRAEAQATTGNPSAGQITSGLPPLDPSLLTFARALYPFTATNSSELSLKENEIVAIMGKWDQASGTEVDPRVDLQGGIEAEWWRGRTREGREGWFPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPN7</accession>
    <name>A0AA38JPN7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3-like centromeric protein CSE4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CENPA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DFJ43DRAFT_1129429</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPN7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="60"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ3736242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="161" mass="18079" checksum="7D52C591931BC7CE" modified="2024-01-24" version="1">MTQAVGSKRKSRPSGGSEAGSPSKKSRFNTARKSTGGKAPRRSNVRQDDEPPKKGRRYRPGTVALREIRKYQKSTDLLLRKLPFSRLIREIAQDMTTTTNGAYDLRWQSSALLALQEATEAFLVHLFEDANLCALHAKRVTIMQRDIQLARRIRGPWGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQ31</accession>
    <name>A0AA38JQ31_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_71172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQ31"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="499" mass="57124" checksum="23ADA70B84088041" modified="2024-01-24" version="1">MASSFTWDTQRLRAFNALINLLSLRNGRQLELKCVNQSVPFINDSYHRIKQRFLDRFAEVVSNRRGGEHVACTIMRESGDHVVIWVARNGGFSRKDISFLKEFSAEMRALAARNVDGSGASLWNLLLNYYLPRLQDYRRRLLVKVQEHRQTLNLIGDEDFKHSLKLFFDILEQPGGTNEFGRLCCQALQIQDIPLVQKLVQTEFKSGSQHQLWKSIGFLARLRRAHRTFLKISRTPLIFRSITLHPITKSQDEITSSHSPLTLSDTLSLLDIRPSRLNQTTVRRYVSPTCSVEKAQKIFYQRQKQSLQVHAELQIILHLARTHVPIENVFQYMGCSKRSCFLCKAFLDSFGSIETRGCHGKLYNQWSIPAIQRIELKMKERLEDTVNRMWDILLQELHKPLQTLAALSESSNGTTPASSSAASILIPERPSEKTKVQKKKFDTTHMRKINWLPRPAARPVPPILSVIDVSRRENTISSASGEAESARAILLRLISPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR19</accession>
    <name>A0AA38JR19_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1021806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR19"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="325" mass="35757" checksum="A4ED865D40450091" modified="2024-01-24" version="1">MTVDTSSNMTMPEPSAQPVVEAPSYGRSSVVETISASPQFQKSARFDDFLVSPLLSPCDDIDMSPSINDSPLLDTPIMNDLSDDFGIYGSEYTGIPLFSDSSLSMYQLLESPELVQEVLFKAYEQTKPAPEPAPTLPPSSDVVSPPLVEAHSIPVSTKNTITASAATVIKTGKGRRSNATGTRKNVTPESLVPVDAPIQARKYVTPSATSRKEIPAAFLKSQKRKRSRTQAFSDEEIQPTPSGSSPCPEGPEMEEQPPLNATEKEIIEWKRRQNTLAARKSRKRKLEHQQFLETRLKDLELENEMLKVKAEALEAALRAHNIFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR72</accession>
    <name>A0AA38JR72_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1060600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1650" mass="185097" checksum="CD479FF6963FE4D8" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSJ3</accession>
    <name>A0AA38JSJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Origin recognition complex subunit 5 C-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1044893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSJ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC5 lid" evidence="6">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="5">
        <location>
            <begin position="382"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3737494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="564" mass="62804" checksum="918D29E9FBCCF1EF" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSK8</accession>
    <name>A0AA38JSK8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_710911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSK8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3736228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="420" mass="45064" checksum="E7BCD28B4D5012B1" modified="2024-01-24" version="1">MPSTSSQNIRVVVRLPYNRPVNQEEQIIDPPKVEWGPEKADILWKVIEKSRASDSGGADWKGLAAHLQVPLPYLLYRVHARYQEDLRGLQDIPGVSSPISPNAPSDAPFGPSIDQAAPSIAGRTLTRLNTRLSPSLLHGTIPLGIRARLNSLGHRDNSSTSSLRPKKATASSSTLTLQTPIARKPAQLQPGLDRPVSPPSSEEDELDSDDDEMLKEEEAEHAAEEQEALDKKLAELQKMITGDMLGLVSVGRKQGSHIAREHVRGRDGPNIPETHHYNASLSSRSASTSQSVSSASSPQGSLPEIPSPTPDSSPQSPQPRSPPLRRHMSPTKSLSPPTLSPRSALGQSHRGLGHAAGRLNDYDKDGSEASTGSFSDISDTSLSASALDSALLSNIRGNGSRFSAFARSRFGTSYRSGAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSP2</accession>
    <name>A0AA38JSP2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1051454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSP2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="6">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="299" mass="34137" checksum="33821BB5A19B4340" modified="2024-01-24" version="1">MPFVKKIKSDAYFSRFQVKYRRRREGKTDYYARKRLTTQAKNKYNAPKYRLVVRFTNKDIIVQIAYARLQGDFILAAAHSRELPRYGINHGLTNWTAAYATGLLCARRALTKLGLADKYQGVTEPEGEFTLTEALDDEDAPRPFKCFLDVGLKRTSTGSRVFGAMKGASDGGIFIPHSEKRLPGYDPEAKELDAEVLKKYIFGGHVAEYMESLEEEDDERFKKQFSTYLADGIGSEDIEEIYTNAYAAIREDPTFKPTEKTKDWKAESKKYATPRLTLAQRKEKINARIEEFRAGGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTM8</accession>
    <name>A0AA38JTM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1037139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTM8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3735246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="108" mass="11838" checksum="DE4082A2D9F30DBD" modified="2024-01-24" version="1">MKNIKTLLIHYTITTAKTALTGLLVGYIHQYMAVVGIQIRHLCFGKYGGCTFQSYVEPSVAGGIWQLIMAQGIVRKAGKSPMKILANGDSSVQGKEEYLRSRKTFIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUD0</accession>
    <name>A0AA38JUD0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MICOS complex subunit MIC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_9064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUD0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12470" checksum="D137A379E0ECF7DE" modified="2024-01-24" version="1">MSFLLGPVSGALVAGGIYYGFSNLIQARTRELSTDLHIQSTLLLHSPTPSWISTYPSPAASRIEHKPFLSLLQAKWNEQVEHAFVWTSQSDKHVSDAAGEFSQWAGRKLTGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUW7</accession>
    <name>A0AA38JUW7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1017892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUW7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="336" mass="35526" checksum="DD590D2CEEAAAE8F" modified="2024-01-24" version="1">MSLPKTYRAAIINSSGSDFEIVEKPLESPTEGTVLVKILACGVCASDGMVKYGMTALPRVAGHEIIGDVVDVPSTENQWKVGDRVGSGWHGGHCHHCASCKESDFITCNAEAINGITRDGGYAEFAVLRTEALLPVPKELDPAEAAPLLCAGVTTFNALRNVSDLKQGDVVAVHGLGGLGHLGIQYAKKMGYKVVALSQSSAKKDLATELGADYYFDASQVNQVEELMKLGGAKVILATAPQGDDIATLLGGLKIGGTMLTVAIADLKFSTLALIGKRSMIKGWPSGHAKDSEDAVAFAQKHNVKSLVETFPLDQVNEAYGKMQSGKVRFRAVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVL2</accession>
    <name>A0AA38JVL2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Poly hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_994761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVL2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="258" mass="28959" checksum="C5C16EF60B15C7D6" modified="2024-01-24" version="1">MEQDTLIASAADPRFSFYAYVPKSEGPGVPLLVIIHGIKRDAKGYFEEMRDFCEQHTCALICPLFPEGVPNPKQQNGYKDIYSRGTRFDHILLSMIEQAGQTWQIQTDRFYLHGFSAGGQFVHRFTYLYPHRLAAVSIGAPGRLTAPDLQSPWPEGVADISEIFGLPGVPDFAAMARIPVQFVVGEKDLGTSMLEHMKNPTKFEIEAGNTRFARTKWLKAAWERIGVVSEMNVVQGVGHDGLKCLLAVKEWLERQMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVQ5</accession>
    <name>A0AA38JVQ5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">DFJ43DRAFT_627190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVQ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3736521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="92" mass="10208" checksum="29033DAAA6CCFB19" modified="2024-01-24" version="1">MDGSSSGIQEPFDLIRLSLSERVFVKLRGDREMTGILHAYDGHMNLILSDVEETIMIVNEGEQATVSVAKRKMDMLFVRGDGVILVSPPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JZ63</accession>
    <name>A0AA38JZ63_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1148968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JZ63"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000077">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3737810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="224" mass="24533" checksum="23D98B384E50E246" modified="2024-01-24" version="1">MEEVSIGILALQGAFAEHQASLNRLNSSRKLNVILVRTLDDLNQCDALIIPGGESTTIALLARLAGLFEPLKEFMKTKPIWGTCAGAILLSQSVVGAKKGGQELLGGLSIKIARNGWGSQVESFEAPLDLNGLEESTRPFQALFIRAPVVLELQSSSDSPITVVARIPLSLLPPSLIEENMTEDDPRTIVALRQGRHLLTTFHPELTEDDRFHEYFVHKCVLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K213</accession>
    <name>A0AA38K213_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1143055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K213"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="31"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3737348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="510" mass="54931" checksum="78C4FF97C9E77304" modified="2024-01-24" version="1">MATTTDAKRDSSSMEHELKPGPQLQQENRTLLFVFCFAQFLDAFNNSALFAAIPPISSAIGISDSNSVWLISAYQLTFAALLLTTGRLSDLYNPKWAFILGLLLMSFSSLGSGFVRSQVPLIVLRAIMGVGAALNIPSGLAMIIGMYPDPVAQGKALGGFAASATVGNVTGLFIGAALAAFVSWTWIFYLITIISFAMAAVVLLVMPLRVSFADGLGLTQGERFKRLDLIGVSALTVSLVLLVFSVTTGSIDGWGEAKVIVPLVLFFVLVVAFFQWEGRIPEHIAAVPPKMWRYQNFTILIILSLQPFMFWVATQLLLSWYWQFIFGWSTINVAVHFLPLGIVSFPMIAVAVFLQKTFSLKWVILMGEILVIAGTLLLPFADSKPHYWKFAFPGFILGTAGTTVVYATTNIALFAVTPPEVAGIVGAIFNCALQLGAAAGSAIITSIQTSTETDQSSFDGRAAGFWFMFTFTTLEAIGVAIFMKNTVPALKAQKQGAVEGGQQEGATESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K2H1</accession>
    <name>A0AA38K2H1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-L RNA-binding motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1142917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K2H1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3737708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="177" mass="20785" checksum="86A039C5CF5DEEE3" modified="2024-01-24" version="1">MVRKLKHHERKLLKKVDFLNWKQDSNLRQIKVMRRYHIQNREDYQKYNTLIGHLQTLITHLSHLPPLSPFRTHLESQILSKLYDVGVLPSSSPSSPSSDVRKLTVSAFCRRRLGVVIVGSATRFVEQGHVRVGTEVVRDPAYLVTRRMEDFVTWVDTSKLKRTVMRYNDELDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRF3</accession>
    <name>A0AA38MRF3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_753572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRF3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="101"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3718621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="475" mass="52060" checksum="9D2C92A0B3167472" modified="2024-01-24" version="1">MMYPSIPTHPKQRQPSSGCPGSITWRNRKFPTEFVDDPIGCRIAEPSSKRSRIEEYSTYSTKRLASDYTPLDPKFKSPLPYKRGPRMGRDQDLRAINPPSNTLIVRNLASGSDPKIVERQFEMYGLVEQFDELIRRRGVAFITYYDRSAAQTAFIKMQGSKIDGSVINIQFELPLSVISGDRNSNLVTDETSGKSTTFSRTPLAVIAGEKSPQDSNPSNQPIGDRRWKPKPDQIQANQSTVEDRLKEAQKLQQLFSTLQCDGSSTIHNLNFLVTSKSQSDSKLSSLAEGAQGLYPGLDVVQSYSPASFVDTDLTHLLQRIKPCRLSKLSHEKPSISSPSPVAHKTSSEGELASSSQSTITLPMLESLHQALSTACATSPTKPDLDSMVAYQWINSFSAVGSHNTEPLSTIPSGSNFDGVACPQFPVSAVTTRPISIPQWTSGGDHSSTLSLLSVSEAVSMPVNQDVLSNPQKVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS85</accession>
    <name>A0AA38MS85_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1089857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS85"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF1">
        <property type="entry name" value="QUEUOSINE SALVAGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="398" mass="44039" checksum="717C8E6AD7F7B974" modified="2024-01-24" version="1">MAHPLPEPSTLLSSIRSSSRLARQNANITISSQAIERLLKSPAFLVSFERVSAQHGLALPLKFSSPLDDLNVISILSLLNFGSGYRIPLHAETGRGAWDNIRLLVFAMFIGGSEEDLLSAQGMQQLNEAKVAELMRVNVYIEKPHKDIPGVTVGELGGPLYELVKLISSVLVETGQLLQKAGYPNLGAFVAEALKEGARHTKPRTSDVQVFLDRLIRFIPAFQDCHIVDGRPIYIFKKALFLAHAITIRFGSISSPSFPVPDTSLVPVFADNVLPSLLVHLGVIDLSSSPSFQSILQDVNLSPDKLQSLFSEMSPELESNVSPPNEGPAVTMDQIYILRAAALDACEMIVEKARELDEPSWIKDIRYTALDMWLWSIAKDRADYRRLGRFSLRDTVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUH8</accession>
    <name>A0AA38MUH8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1070861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUH8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="85105" checksum="555E6D69E2DB6718" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV11</accession>
    <name>A0AA38MV11_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_858139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000089">
        <property type="protein sequence ID" value="KAJ3714640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV11"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3714640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="629" mass="69947" checksum="CF89225F51E26DE2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV24</accession>
    <name>A0AA38MV24_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1152675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV24"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3733979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="337" mass="38438" checksum="D6CD6B89CD55FA52" modified="2024-01-24" version="1">MTDSPSASPFFSLARELRDKIYDLLLWTPIGTALPSIPGHLLDIPERYYVNRPICDWHWRIPVSRGSCFGILYTCRQAYAEVVECIERQERHGGMSFELDIALIGEPALEETMYLGSERIWPTWILLPLCTYPVLIHDHKDFADSLTSITVNSKCKNLHVSLRLQSELTYRWLGNGGLSRLTRNLFTMLARFLLYGPAGLSRKTDATRVWSIDTLSVNVLSTGTFTDSYSDRPHTVPIEVVEDSVICLNDLLHRLCNAGALSDRVRVVRLSVEGVLKNEWLINGGESLPPPEREVWAAYGWTIDKEDRLKELNPHGIDMTPKERHLRWSLNSCCRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVC8</accession>
    <name>A0AA38MVC8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BAR domain-containing family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1104273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVC8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3714337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="313" mass="34347" checksum="C6595DDADE894B22" modified="2024-01-24" version="1">MDGWKSLQSGLANLNLGQSANKFTKGFQSSVQATKERLGQVSQDEITELPQEYKDLEARVDALRNAHLAMLKITKVYETEAYDYPVQIQESISELSNTIGTNFQNFAATNLKGTPLSPGATAPRPHLETPHKTLPHALTRASHTASQLLVSTPAGDSSKLGKAFALYTQANETISNARILHDEAVQDGYLHPWQTTLSTSINVAMKARQAVRTSRLELDAAKQGLKSASHARQEQARLEVENAEDDLVQKTEVAITLMKTVLENPEPIKNLNELVKAQLVFYSTAAEALSGVQGEIEELTIAAEGEYRKSRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVU8</accession>
    <name>A0AA38MVU8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1005854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVU8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="909" mass="104660" checksum="4084BBD4B77B4B4C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVW4</accession>
    <name>A0AA38MVW4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1060266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVW4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="272" mass="31044" checksum="A8523174E58B3775" modified="2024-01-24" version="1">MGKLNIAHHKSYHPYRRDNIEKVRRDEEEARLQEAKEEGRMLLADSEARIDLLRQKSGSSKKKVDDELRQLASSSTAATSLSNSGGHINFFEDLEQNAIVAAAKASKKSVPAETDKGVALAPSAKDLNPWYSGSSDYKDTDANDDKRKRDTARKSIHDPLTSINHQLASTSTQSSIKPRFARPRSPKFSSQAPEVSARLSRESTERERALALIRRKKKEMMVSDTPSTIRGGDESSEYGDMYNKRDVEEAHRLRDRRWDDYRPRRRNDDYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW34</accession>
    <name>A0AA38MW34_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1158993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW34"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="103" mass="11220" checksum="1E77B120A5351037" modified="2024-01-24" version="1">MALLVDSTTTQCVGEPLVEYEWSLTRPTEVEGEADDHSVSEFRIPLDCCGDVSSDKNRVMVTEGICLALQLLSLDFNQGQPGERDGTGNLTSINARIYRGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW68</accession>
    <name>A0AA38MW68_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1134297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000069">
        <property type="protein sequence ID" value="KAJ3718607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW68"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="832" mass="94309" checksum="E5ECC7CD829EED92" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWD3</accession>
    <name>A0AA38MWD3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1098810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWD3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="194"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3718038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="580" mass="64327" checksum="76BF6814D0018479" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWD8</accession>
    <name>A0AA38MWD8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_774706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000070">
        <property type="protein sequence ID" value="KAJ3718083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWD8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="239" mass="26477" checksum="9AD40D6D87F0BD5E" modified="2024-01-24" version="1">MISTPASTGVTLVFCLRLSNKRTLWVSIHIPSTFRDENPNFAQDVKEAHPTNMFRDQPEIASLLTQIPNLTTDVGPSGILCISGSFRVKSATGDSVPPQDYPAGILNIEGLDEATKSVSRNMLMRRLSRIFATTKLSTRPLTLSTAAQDNIQAKDKKRHRSSPRVRTIGVAIRPSGINLRTRMDRKGAGRTLLQRHSQHRLGAVATGRASARSYSSRQLFSIVESSSSSNTFRYKLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWK3</accession>
    <name>A0AA38MWK3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1031615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="630"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="673"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="716"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="759"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="802"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="845"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="888"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="934"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="4">
        <location>
            <begin position="958"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3720294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1353" mass="149385" checksum="630D17ED0435A3F2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MX64</accession>
    <name>A0AA38MX64_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1005544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MX64"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3719093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="234" mass="25707" checksum="39924592DA4C07B0" modified="2024-01-24" version="1">MAHRSPTQGKQLPKTTNIEDWARSDIYHNSFLIPQDPVLDAALKNSVANGLPEIAVSAAQGKFLHLQARSIRAKRILEVGTLGGYSTIWLGRALPEDGELITLEINSKHAKIAEENLHNAGLFPKCKVITGPGHESMVNLPSESKFDFIFIDADKPSNLKYFTEAKRLVRQGGIIIVDNVVRFGRVADPEQSDANIEGVRLLLNALKSDQDVDATTMATVGEKGYDGFIYAIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXU6</accession>
    <name>A0AA38MXU6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1156833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXU6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF215">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56624" checksum="F83F021522D9DE5B" modified="2024-01-24" version="1">MISKHIVAHNVAAWGAYKPLSAFVVRITESRKDVIFTVLITGGMMYNKFLRELAKLSSARLGAISSRINVIDLTGQDVNPLVPLAEFMPAFEAIYLSKPITCKATGTLIEGLPRPTVALIDPFAGYAVDAIREIAGSKCSILSWMTAPAGATLRLVGPEEYGGVGDLSPKVEAEVALSGKSYAEVAKNLYDSFTSGEIIRVPGIPPMYDYEWIPQEVHFFITSQKYMRMTDGTFCVSSSVYEPEAMNAARQWMKSIGKAWYPVGPLSLQESILPTRAHDEKELQVISFLDRMQAMFGKQSVFFISFGTIFWPAQPDKLWAIIDDLIALRKPFILAHTSSLAHVSDEKKKLIADSGIGLEMAWSPQEKILSHPATGWFITHGGWNSTQEALAHQVPVIYWPFASDQPYNAARTVQHNAGFELIEVRTGKPGTQLPYRLKHSNISERPTFSIPAAQKEFRALLRRIEGEEGCMVRANFERLSKLMNESWDEGHEAEESLRAFLREFVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYC2</accession>
    <name>A0AA38MYC2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation protein SH3-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1084654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYC2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3729078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="179" mass="20148" checksum="F638FDE472A70931" modified="2024-01-24" version="1">MLPNLFKWTASSSTRLMSTTVQTVIKPYPFSKTAIIHPEPYVPPPAPLVQGKGLMPYLQKNLTTPEKQTMLRELFGRHSTKRIYPGSIVGVMLEHAPFSFTGVVLAIRRRGIDTSMVLRNVIQRTGVEMQLFVNSPHVKNIKVIQKPPKGRMKRAKLYYLRYSPEKMGALAGSKKGTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYE4</accession>
    <name>A0AA38MYE4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1090430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYE4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3724278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="213" mass="23197" checksum="E894542C8F718F29" modified="2024-01-24" version="1">MPQHPEVLWAQRSSSTTPEKNVIYLTVNLPDIKESSLKFGLSETSLQFSATAGDSSKGIDEKEYGFELEFFKEINATESTKRLNSRSLYLILRKKDMEEEYWPRLTKEKVKNSHIKTDFGKWVDEDEQDGEPAPNDDDMSGMGMPGMGGMGMPGMGGMGMPGMGGMGGMGDMDFEKMMAQMGSASGEGAGPADDDSDDDNDGPPPLEDAEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ37</accession>
    <name>A0AA38MZ37_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1084107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ37"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3728975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="126" mass="14458" checksum="3A82A5371244E7AD" modified="2024-01-24" version="1">MVLRPIDLMRYRRSVLLLYVFLLFVRYSPVLASSLVSFPRIPPYFLHLPLTRLAIRFVLGIRLGSSTMVNHSLVVSLRLNPEIFDDLVAGIGPQWLGLELFYAPLEIIRSESALGAAWARLRLHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZC5</accession>
    <name>A0AA38MZC5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_417331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZC5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="90"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3731536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="525" mass="57869" checksum="19237E77B97007CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZN8</accession>
    <name>A0AA38MZN8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1156251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZN8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="365" mass="40493" checksum="D782D4E7ECDB5D0C" modified="2024-01-24" version="1">MNSELIIALTKVLTVTNSELITVLTKVLIIVDSELITVNTSVLTVTNSELITVLTKVLTVLSRVLTVMNSELITVYLKVLTVMNNELITVLTVLSRVLTVMNSELITVLTVLSRVLIVIHSELITVSTWVLTAMNSELITVFVKVLTVIHSELITVLTKVLTVLSRVLTVMNSELITVYMSAHCHEHELITTYTRVLTSWTVSSIIALSDELHDVTIRCSLCPSVVLTVMNMSSINALSNEPHDVTIRCSLCPSVVLIVINMSSMIAVFNEPHDVNIPQNCVVTVMNNELMVELTVVYDELDVIHSVLNILLIVIDSELKVFVTVYNELNALVIVTIELNVLLTVSYSELYTLLINFYSKNIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N037</accession>
    <name>A0AA38N037_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1079242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N037"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="79" mass="9443" checksum="06ECE893E18D8CF0" modified="2024-01-24" version="1">MFIDQSCLFKIGVYLQVIVIVSYVYLPVMIIQEWGLFTYCFYSRSVFIYQSCLFTTCCDSVWCLITYQCFFLFNLLCMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0K4</accession>
    <name>A0AA38N0K4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1075988</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0K4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="17">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="16">
        <location>
            <begin position="164"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3732182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="454" mass="51493" checksum="2BBE64D235CFE964" modified="2024-01-24" version="1">MLLRTRFPGNNKRWPTGLWRAGYFGRESIQRLYSTSTPRITKREDNKGSLQINWEPQTNTQSRFDYIWLRDHCLCTSCVHPKTKQRMLNTFEIPNNIKPLRADNRQDGLVVVWPHEHESVYPWEWLKRHSYDPPIVQSSQPQQVLWNSQISNSPPTVSYEDIMKPGEQGDRALLHWLSTIHTYGFSFISGVPPTASATETLVRRIAFIRETHYGAFWEFTSDLGKGDTAYTNLGLDVHTDNTYFTDPSGLQLFHLLDHSRDSNSLGDQTTSGDQTTLGGQTILVDGFHAASLLRSNHPSSYHLLSNLRVPSHASGDFSSSGYIFRTEHPTAGYPVLTHNPSTDQLVQVRWNNYDRAPIGSTFLDANSALSNAKLIPKFYSALSHFHAILSSDESRYVVQLKPGTAVVLDNHRVLHGRTAFTGRRRMCGAYVGADEWRARLAGLRFTFEDEPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0R4</accession>
    <name>A0AA38N0R4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1069763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0R4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="366"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="847" mass="96515" checksum="B45CA1C9D3DF83CC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N175</accession>
    <name>A0AA38N175_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1223151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N175"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3733471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="526" mass="59173" checksum="32717F8C90AEA1DC" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1H9</accession>
    <name>A0AA38N1H9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_267411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1H9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="595"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="599"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3732932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="91951" checksum="88240237F6384877" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1U8</accession>
    <name>A0AA38N1U8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1070418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1U8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42024:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="362" mass="40795" checksum="F70625DE86FEA3E4" modified="2024-01-24" version="1">MTPSEHTTSGVDSASNSPMNFVSDDSNDVLTLPDLHFSYRKTSVALYIAFLIICNVLIPCLLFYLLQTFTKITTKELIGISSAALGLSSCFDAPFRLFRLVRSRTTYGPLGTDVWWHLDFVMWTYTFALLVFAFPLAIAPAIAFYNFFLMSTMMLVGPVGVVFIFSLIAYHYKWRLPVRCSSEPVGSLMKPAVFYCIEDVGAVDFMHGRKFRQRVHTRYDASPPFRQLMTELTVYWVICGAIYCGLTATVTWAATLNFAFGWVLGQFFIWAFLSWTGCHFLARRGLERERAYWDNRGRTLFKEKTGPGGINEGGEEEKPPKRSQSAPGIPHTNDGTTPDLKPAKSLDVPPSFKPKAERTEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2M7</accession>
    <name>A0AA38N2M7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1067841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2M7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="5">
        <location>
            <begin position="515"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="716"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="749"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="809"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="965"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3733578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1145" mass="125326" checksum="5778458DF12F3CEB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N310</accession>
    <name>A0AA38N310_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_993078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N310"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="290"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3734402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="359" mass="41033" checksum="BA167FC9D38CC4E6" modified="2024-01-24" version="1" fragment="single">MPKEVESRLEKRIRKFLWDDKTLARINKETIYAPIEEGGRQLLDLLARNEAILVTWLQGYLNLNEKRATWTFVADAILTHHVPSKYTNLEEREKINVFLQSWNSNTSKLPKDLRNMISIAKKYGARLEGLTFSREILRQMPIWLHSEAKNAHKLRNSKESRCLRQNHNVKTVGDIEAQVNKTRTPRHGRRRNCRCMACEAARTENHCEAPYRCFAKAKELLQTLPEKWNPLSILPEDHEPEELHPPDVNEGTTFDHRITTRGSLADAFRIFTQGETSNAIPRTTWDPQPANTKVEVYTDGSCQHNGSDEARAGAGVYYSEGDALNKAIRIPEYLPQTNQTGEIISITTAAADVDPNHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3N9</accession>
    <name>A0AA38N3N9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1061472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3N9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="81" mass="9385" checksum="C475692EE4B08194" modified="2024-01-24" version="1">MAPSPYSQLQKKLFKLINQADFDFFLPKLSRTTWDTIINDSDERERLEFVGDFYMSAAVGESLCRYLPNGSPHQYTVRVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N477</accession>
    <name>A0AA38N477_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1052643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N477"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="294"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="912" mass="101126" checksum="0386186FB5135EF0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N4X0</accession>
    <name>A0AA38N4X0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1051408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N4X0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="105" mass="11225" checksum="86B1A8E627599D3A" modified="2024-01-24" version="1">MPNMSMSSNSESLFANRHNKSTDPLGHSSPTSTLSGSPPSASAILSTSLRSLSHEASRTSLRGTFPSSNTSLIGTRKPAIRADPSMLTCFDPADKELYDLWAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N5Q1</accession>
    <name>A0AA38N5Q1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1044992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N5Q1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3737508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33353" checksum="BE8256D97F43A455" modified="2024-01-24" version="1">MSNESSFSYHPLFSSPEADTVISSLEGTLYRVPSFVLRSTSRFWDTLLSIPSQSTSTSSPIPASQNNVILEPMLCLMSGLPIPPWTPDPESEESDEKCITEIENLLMLAESWDAPGPLSFLRLGVTSHMFLEQPLRLYALATHFGWVPEAKLASKYSLGLNLYDDEYEEVLRRLSAKDLLALLRLHRARRDGMKSRLDDPNVFALGNSGTSSCSFCNGIDEVDHSAWRELKARIFKEMDQCSKGDFIGSWEMEEWKETEQCWKVKCRVCSRLSYHKGQTILKMKEGLRLLPETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J263</accession>
    <name>A0AA38J263_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1135066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000112">
        <property type="protein sequence ID" value="KAJ3712086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J263"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3712086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="392" mass="43764" checksum="29C1CD6E16B74608" modified="2024-01-24" version="1">MSWMSETQGETITVYTDGSCENNGGEDAVAGAGIFVRDNNPLNRAIRIPNELVQSNQTGEIISIKEIAEAAPPSTGLDILSDSLTMVEGVGGKGFTNVANNLELQVTAARMRARRAPTKLKWVKGHAGIQGNEKADELANAGRQKDEEDLIDLTIPRDLRVTGIKLNTITQSLAYTRIREELTESEGYEKATNRTNTAKNLRLAKLAVLEDSGKAVTDAQIWVSIRNKDFSRPFRYFLWMTIHEAYKIGNYWNRINWETQRAECQTCNIMASGLTQVTNRKGKPDKGKSRLQRIVISESAHLIWKLRNIRVISGREPPSKKEIANKWHFALNSRLATDRILTNKKTFSNRAIEPTLVLNTWRGTIEDEGNLPEDWTREAGVLVGRCTALDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4D0</accession>
    <name>A0AA38J4D0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1158942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4D0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="1">
        <location>
            <begin position="190"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3720286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="374" mass="40738" checksum="712242A0F3C466DB" modified="2024-01-24" version="1">MAWPTLNDFTIRQNASWSTATPNPTRQSYVAKEAVFQFPTSADRLFCLSRGSGPFGGTFHLTQSDRIGANSIEMKVIVEYWIGNAHTLESILRVCELSRRENQYGIGILTRPPPGFERNYEFHADIQIIVTLPRTQPAVVLKLKSFETDLPMFSHLVDNLASTVYFRTISLRTSNTPILVESISAGKANIETNNAPIDGLFATNSSLRMTTNNSHIRASVFLQSNDAASFSELTMRTSNGPINGSIILGASLSSTTTSERGGNFSVNASTQLGGLSLTFPSAPQSCNLHLHGSTSLGPADITLPKTYEGTFHAQTSMGLASAGLGNGMERERRRLVFEQNGAVLKKGWICSSDEGRHRGEAKVMTSMAPVMLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4V5</accession>
    <name>A0AA38J4V5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1226801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4V5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041353678" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3721332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24279" checksum="0C4350A2910F0582" modified="2024-01-24" version="1">MALKTIFVLGSLILMSCAQEPSWLGKYIIQTLTVQDSERILTTSLDLELGSLISDVGNTGEVKEVINFQGIPRNDLVAKIFYSRDVGPNLVYAEVKALKQIGEFHAAGYHDESIVILMEKKPGEMIADTVQWKQAAYSKRSYFLREAKQKYCEKVAKIATTKKVYHVDDNDGNFLVQFDNTTETICSVEVIDWGVALFVNEPVPNEKEVYQYCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4Z0</accession>
    <name>A0AA38J4Z0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1093102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4Z0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="368" mass="41209" checksum="F283CB80DD736C6C" modified="2024-01-24" version="1">MAYLCQLRIRTDLSTNAFRERPAVRRSVQSIRAVTIFQYCMVTVHISLAFFQNYLAFTVYDNAETEFNRLGAAPYTIAQLAIEWTNCACADSILIWRVWILWGQRLYVVILPIILVILSTTSGYLVCWSMDTVDSSTSSDFGDLFGPTVEKWAILLAVCIILTNIICTGMIAGRIWWHNREIQKAMGVNGMPHKYRTIFYGVLESGALYLLAWIVAILLYLINTSAIIPMLDIISQLSGIVPALIVIIVSRSVDAATHHEEVLTTMKYQRDSHPQKRTSYTVNHEARTSPVNSLEMFPVHLTNSYEPESPAEEKRMTFSENTSLEKIPIPKSAARITTTGTRTTTSGTSSRTMTMGVISGGESAEEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J610</accession>
    <name>A0AA38J610_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1108764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000135">
        <property type="protein sequence ID" value="KAJ3710605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="26"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="427"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="740"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="817"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="955"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1073"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1086"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3710605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1310" mass="146568" checksum="B088EA113B6B4EC7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6E9</accession>
    <name>A0AA38J6E9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1194641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6E9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="425" mass="45492" checksum="AC6BC348CE9BB969" modified="2024-01-24" version="1">MITTKNDKPNVVVIGGSYVGNKVVDEITPKVYKTHNVVLIEKNSHFRHLFAFPRIPVVPGFEHKAFIPYTQPGSTDASAFFASVNAATTSTAEAVEGYTPLPSDSIQIVHAAATAILPDKVILGNGKDTIPYDFLVLATGTGRPGPDGLVGQDKEAGVKIGKFHQENVKKAKNIVIVGGGAYGIQMATDLKTHEPTKSKHVTVIHSRPHLLNRFHEGLHEITLNKCKELGIDVILGKRVVIPEGGFPLETTDEEFDVHLVGGGLVRGDLVMLCTGAVPLSEPLKTLAPTAIDKNGFIHVKTTLQIDAPGISNVFALGDVADTGAHKAARPAIVQAGVVARNIEKILQARASGQTQPEKFNEYNADAAGIHLSLGLNASLKFRNPTAENPNPTIMWDETGSQKLDAGCSKVWALRATWAGKDSYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J739</accession>
    <name>A0AA38J739_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1084012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J739"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="177" mass="20085" checksum="4368EBAD72277172" modified="2024-01-24" version="1">MSTTPVPRLRVASASRRMVENLKSFRNKMEPTAHTPSSSTSFSDPYAFTTRHQPVYFPPHSPRCRTWSHSECPEFIHQDGDGGSGIVILILIMIPVHALTMVTVQVMRFTVHRHPLMPIDLVRMTMGTTPSEVKIHSLFDELGIITTKIHSMISWISIQVCLYLTTPIYQTQARIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J772</accession>
    <name>A0AA38J772_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucan endo-1,6-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1001671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J772"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041414825" evidence="5">
        <location>
            <begin position="19"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="6">
        <location>
            <begin position="68"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3727302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="533" mass="57363" checksum="9163492747149825" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7M8</accession>
    <name>A0AA38J7M8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1002548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7M8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3725566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="125" mass="14231" checksum="312CD9A00025845F" modified="2024-01-24" version="1">MRSPITCHVLNTSTGRPAQGVVIKLQQYEETEGNAFLFNPIAEGKTDSDGRCTDLLPPTTSIETENLLKPGLYKMIFRTKEYFDSQSVKTFYPWVEITFELSDLTEHYHVPLLISPYGFTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J808</accession>
    <name>A0AA38J808_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1000356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J808"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3730048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="179" mass="21065" checksum="0D377F283028C1D5" modified="2024-01-24" version="1">MPTLYQILGIRPSATAEEVRRAYKQRALETHPDKLEPGASNVDKEHAERSFREVHDAFTILGDVEKRKAYDIRMYIPTSLSYQKASDEVKRKMEDRAEWQRQQQELRKANMAEIREQNRIAMEKARERRLKAVEQAALVQNMVDELSQLTPEWEQRKLHVQQVSSEQFTFFTSECLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8F1</accession>
    <name>A0AA38J8F1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1209629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000073">
        <property type="protein sequence ID" value="KAJ3717599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8F1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3717599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="148" mass="17114" checksum="A7FAE6477EA0F72B" modified="2024-01-24" version="1">MKTSRVDDPPNDDIFTSGRWNVAEQTALFTHIFGSDSDHIHAKWLKNKDRVYTKYLQANHSVAERFTVKSVASKITSSITMYGYMREYEEFTGGGGDADLQSMVPESDEWHKQRLILAKRGGKSIGSLTVKKYHEWKDNGWYDIFEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8H3</accession>
    <name>A0AA38J8H3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_965016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8H3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="231" mass="25828" checksum="BE30FDCFD6FE3CA6" modified="2024-01-24" version="1" fragment="single">RIMGGTGTGKSSLIRLLTKDTGVKIGSSLDSLTTDVQLFRFLDHTSGRNIVLVDTPGFDDSRSDITDTAVLKKIAAFLLNEYDRKRQLNGLVYLHRISDPRFGAQASRNLKIFQNICGTKAYKNITVLTTFWDSVSTEEGLMREEQLKSTFFNHIVAQGARFMRHDRSTQNALEIITHILTLTPTDVQIQEEIRIGGKGLEDTAAGSIHREEVERVLAKHKQEIASLGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8R1</accession>
    <name>A0AA38J8R1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase I subunit RPA34.5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_998714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8R1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="279" mass="30914" checksum="1360EE330B19B4A0" modified="2024-01-24" version="1">MSESDSSSSSLQPTITEKSKSKTSNKNKSKTNSAANPTSEDDPTWAYQPPEGMSILEDAEVDEGWDWDTLEKDPELQLWVIRVPSGVKPKHLQNLAIDLSGPSSNRYTKVGALNRKQESYDIWNLGSSSTSDAVAGGGEEIRGLTCLLPRKKKRGQLFIAPRPIARHLIISAQPIIPSSSDISTETATLTQNPPRFSYPQELLKHRFVAFGSTKNTNAEDAHYGDGDDDIQMEDVHMKSDKLTQKTTEKVSKQSKESKKRKKAEDAAMPTPKKQKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8R8</accession>
    <name>A0AA38J8R8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1100751</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8R8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="211"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3716744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="298" mass="32183" checksum="DFFCA7A2ACEA0596" modified="2024-01-24" version="1">MSPPTGKGNDSGTARVLGSGTSGVAELLIFHPVDTVAKRLMSNKAKVSLATLNPILFRDHATASLGKKFFSLFPGLGYAAGYKVAQRVYKFGGQPYFNDLINQHFRDQFTNAFGERKGKLMMQATAGSLTGIGEVVLLPLDVLKIKRQVNPDAFRGRGIIRIIAEEKSALYRGWGWTMARNAPGSFALFGASAVTKDYVLGVTDYSKATWTQNFIASIAGAVTSITVAAPLDTVKTRIQNANFESKVHGVVVIKDLIKNEGISAFFKGLTPKIIVVGPKLVFSYTLAQSLIPLFGQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8T9</accession>
    <name>A0AA38J8T9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1009463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000161">
        <property type="protein sequence ID" value="KAJ3709695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8T9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3709695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="40451" checksum="7D667716C803ABB8" modified="2024-01-24" version="1">MVFGGRAIPRTWCAFASLILWILVRKLDIVGLHMYMDDFFGWDFDNNCAFFHGRLRPKRQIQLLIFWEYINCPHEDRKQDSGACLKIIGFFININFGSISITDSSVNDLVSRINSFLDHPQRKPILRDWLQLAGHINWAFNVLPWGRPALTELYAKVDNKLGMSAGVPLNVAIRESLLWLADILPKSIGVRFLNDGFRPDSDADMVLWTDASKIGLSFTFAGNGFWYQIASSPQGPIVNIFFLKLVAILSAVSHVASLPSPPKKVLLWSDSLDSVQAFNSLSVRNPAHNAPLLAAAGIILQSGIDLRVRHIPGKDNIAADLLSRLLLDDFHRQFPAYRIRPFDPPQDQLPMRWRRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J926</accession>
    <name>A0AA38J926_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1026278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J926"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3731827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="369" mass="41862" checksum="778F9746B899BFEC" modified="2024-01-24" version="1">MSSRKSSSKPLPKFDIGEDYQLLYALGQGAYGTVAAGIHKPSGRQVAIKKILPFDHTLCCLRTLRELKLLKFFSGSCVNENIITVLDIVKPSSLESFKEIYFVQELMQTDLHRVIRTQHLTDDHCQYFVYQTLRALKTIHSADIVHRDLKPANLLLNANCDLKVCDFGLARSIKTTAPVGKGQGGMTEYVATRWYRAPEIMLSFKMYTKAVDMWAVGCILAELISGRPLFPGRDYSHQLDLVLDVIGTPTLDEFYAITSRRSREYIRSLPIRRKRSFASLFPHASSDAIDFLNKTLTFDPKKRMTVEEALQHPYVAAYHDADDEPAASSLSPDYFQFDLEKEQLSKDDLKKLLYDEVMSFQSVLVNPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9Q3</accession>
    <name>A0AA38J9Q3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1207185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YME2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9Q3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="138"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="650"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="842"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="909"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="662"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3718662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1108" mass="121442" checksum="5BC2879B5817591B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAI4</accession>
    <name>A0AA38JAI4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1070330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAI4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="39"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="294" mass="32194" checksum="F66067A35B3CF50B" modified="2024-01-24" version="1">MSDSSDEDIPMNRIVKLSDIRTIADLYKSSVLKAPAIGQAKFKPNNAFLDRVSLFQGDITELQVDSIVNAANKSLLGGGGVDGAIHAAAGRELLKECATLKGCDTGFSKITGAYKLPSKHIIHTVGPVYSASFADIKARQLESCYQTSIDLAVERSLRHIAFPSISTGVYGYPIEDATHIALNVVRKHFESEGQSDFKLDRAIFVVWSDKDKSVYESLIPEYFPPSDEIKLLDAEETEDESDSQAEPVPESQIDEELEEVEKAEGNIANNGAEEVVNPQEEHVLETSEEDTKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAQ6</accession>
    <name>A0AA38JAQ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1091503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAQ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="358"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="457"/>
            <end position="460"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3723545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="547" mass="61828" checksum="D4B0206B252BD874" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBU3</accession>
    <name>A0AA38JBU3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1076464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041256046" description="CSC1/OSCA1-like 7TM region domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="930"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="4">
        <location>
            <begin position="887"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3731934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1356" mass="148288" checksum="2B9F91BBA83592E1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC98</accession>
    <name>A0AA38JC98_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1064047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC98"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32739" checksum="6FD19D8DEFD42924" modified="2024-01-24" version="1">MHIYFELISRDDSSNDNDSSLSPIYIAGIALIGSIVLGVSVWLTVRQLRKRARSKRESERGAAFLSVRGVVRGAQESLSEASCIAKGTSFSRNQLTQSVVLPDKILGHPSPSAPPADIIEYHQQSGNFPRPSMISQPFSFALNAGNESMLRPQTDNRGSWISFLSASGSGRSRFSVISSASSVDASPTTGTIRKIRQLFNPILPDELLVVLGQKLNVIQSFDDGWCVVNKEGGNTLAQTGLLSKQAGRDSNAEIGLVPAWCFLKPVVGLKGERPIRSSSLGITVQMDGPAFSSRDEIVSWSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCI2</accession>
    <name>A0AA38JCI2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1039298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCI2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="488" mass="55342" checksum="D586AEA565C2BC33" modified="2024-01-24" version="1">MARNVSGSGWVDMGTLKSGCQLLTANPTLDALEELWGYVATNLEDRGITEEAAKKKEFLRCFAKWSDLKDTLAEISLTLAGKSWIELPPTSEDPDDFISRPFFDAIRDKILGKDWARLYDMKRDRYHMISDPLGFSKLVTLMETHNRRLRGTMYHRSNEVLQTLIMQKLPEKFRADLRDCKVSEQLPYAEWKAACKDVEERRPPVSTTYAYPMRRPEGKPDRSSLPSTTTNHNASSGSVPSYPNARSHRFPKLQLDQKRILIKLEACFRCYNLFAGHLSNNCSNVGPPILSVPYRPLNDADVALATKIHDAAPDNSIPYELILKRNVGPGPPPKPVAMVQDRVALTEIPNLDIDRPEPTFSVHSRDVAAVYGSRDVVHFSSGPDVYGTALDRGFDYKEPAAPPVRKPVATLVPARRSVRYYREEGDMGQRSPYSPPQGRNTRRPYLLPPGHLVPRPMEMTAVFRKARVQYRLMLELRWSLFVHALPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD67</accession>
    <name>A0AA38JD67_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1117702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD67"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="339" mass="37732" checksum="DCA22B2B5BEE37EE" modified="2024-01-24" version="1">MSTKKLILVIGATGRQGRPCVSALLAPQDDGTPSLYSVRVLTRDPTSQQAQGLASLGAELFKGSFEDMETVVVAFEGCYGVFVNTDTFSVGEQKEIYLGIKMFELAHRAPQMRHFIWSGLDYGSKLGNFDPKYIAVQSDGKGIVSDFLRSQQSSPSGDLLTWSIITTGPYIENLGGVLLGPLAERENGAVVFALPVGDGHVPSISLEDIGWWVRYTFDHRSETSGQELKIATEMLTIDQLVETFTRVTGIPAIRKRMSVEEYLDRYPHTNQSIMRGEKGPSIKENFAGMFRVWGDDLLTRDMEWIRRVHPTGYTLESWIKEKGYDGTLSPDLKLFSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDF2</accession>
    <name>A0AA38JDF2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="10">FBP aldolase</shortName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1132882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDF2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3730011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="356" mass="38734" checksum="3AE162B59B6A9C5D" modified="2024-01-24" version="1">MGILDIVPAGVLTGENVVKLFNYAKEHKFAIPNVTSSSTANACLEAARDIKSPIILQVSQGGSAYFAGKGLANDKQQASIAGAKAAALHIRTIAPMYGVPVVLHSDHCAEKLLPWFDGMLEADEVYFKEHGEPLFSSHMLDLSEEPKEQNIATCVKYFKRMAPMGIWLEMEIGITGGEEDGVDNTGVDNARLYTQPEDIWDVHSALSAVGPNFSIAAAFGNVHGVYKPGNVKLQPGLLAKHQEYASQQLGGKVEKPLFLVFHGGSGSTKEEIRTAVVSGVVKMNVDTDTQWAYLIGIRDFVTKNSGYLQSQVGNPEGPDKPNKKYYDPRVWVREGEKTLYARVKEACEDLGNVGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDL8</accession>
    <name>A0AA38JDL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="15">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1091551</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDL8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000069">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="73"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3723554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="328" mass="35859" checksum="2A140A7A93B5C650" modified="2024-01-24" version="1">MLSFAATTRQLGRTQLIRTATRRSYATETASKKPSNLPLYLMGAGVAGLGGYYYLNSTGKSVITQEKSPLDPENFKDFRLKKIIPYNHNTSEFIFELPNNEASLLPVASCIVVKASDPEALKDEKGKPIIRPYTPISASEHKGELTLLIKKYDNGNASKHIHGLKEGDTLSIKGPIPKFPYKVNEFEEVALIGGGSGITPLYQIVTHALSNGSNRTKFTLIFSNVTEADILLKSDFEALKKKYPTKFDVVYVLDKPPAGWTGLSGYVSKEVIQQHVAPASLNEKVKVFVCGPPGQVAALAGKKAGMKQGELSGILKELGYTEDQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDT5</accession>
    <name>A0AA38JDT5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_90357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000119">
        <property type="protein sequence ID" value="KAJ3711445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDT5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="237"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3711445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="395" mass="44707" checksum="4F1C769A5CB856B3" modified="2024-01-24" version="1">MNPNENTTATKQLRASTPPSLASVQSPEILARPETASSATFRTDPKLLDKVNESVSGLPEFIGEISVDDYFKHVLPPLPSHLENKVVEVCNILNKNGTYNTTTRRWTQFPQDPNAQSSHETQVFLPLAEIFDAIIQAAQQLEPGLEPNFKLVVDSYATPMSERGDDMRPDGYFKITDKALREMGKKCEVLMKKEGWEDVPGTSEAPHGTTNERKESLQPLTKAGEKPKKPPPPPVYGITAPQEFKKQDFMEDSENDIIKLMWNMSSILALDPCRRFTLGFTIEDRWFRLWILNRGTLLRAQAFDFIEDQRSLVTVLLSFALTSAENMGWDPTITFSHRDSDNRRQYNIIVNERVYQTVTPFPTTLLTILSDALLECGKCKMHRANSCPQRSLART</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE69</accession>
    <name>A0AA38JE69_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily multidrug-resistance, DHA1 sub-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1133320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE69"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3726360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="472" mass="51949" checksum="21F94336ED30E4F3" modified="2024-01-24" version="1">MSCPPTTSDDETQPLLRHDAENSPGSTRLHRYSLYLSQLAVLCFLRMLDPLNFTQIFPYINEFVSKMHLTEDSSQIGFYSGAIESIFALCQLIAIYPWSSLSDRTGRRPVIIAGTLGLTFSTILFGVSQSFLAAMIARALAGLFSGNVPIIPTVLCEITDPESESVVFPFFGIFWPLGMILGPLIGGSLSNIAQKYPMFFDYLFLKTYPYFLPCLVIAAINFAGVCSAYFFLRELVNFADAKTLSMKELLSNRMIHCLCTSACFLSFVSTAFDVIFVLFCYTPILKGGLGLETSQIGYALAISGLSAAFFQLVLMPTLLRRVDHAKCYHFTIAVWPVVFLILPGLNIFARNSLRGNNENLDDDATAMLWIGIGVVLVFAKIGFLPYTINTLLVKRYGPSASSLGASNGLLQFFICLSRSFSPFVSSSVFVVSAENNLFMGYGWAILLSVISLGSTHFSGCILAESKRLHTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEI1</accession>
    <name>A0AA38JEI1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1002330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEI1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3726346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14364" checksum="F9E6736739CB2807" modified="2024-01-24" version="1">MEEDLIGLEDLEIDLKRFYYAHDNDQKNTGRLVQNWFSEKNLAQLKWPASSPDMNIQEHVWAELEAIACRYEPAPHTEDEMWEVLQWAWSEISMEFIVNLYASLPCRINTLIKAKGWNTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEJ3</accession>
    <name>A0AA38JEJ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1003088</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEJ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="121"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="162"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="366"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3724251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="573" mass="63499" checksum="4F09523ECCA265E2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEL4</accession>
    <name>A0AA38JEL4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1114722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEL4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21396" checksum="C24D52F085EFD22E" modified="2024-01-24" version="1">MAVPAEFTTLDISGKFVMNKSLSDSTEEILRLQGIGWFKRKIIANGTLYLSIKHYKDDNGIERIDIDQTLSPGGMGSREERILDWSERSKDDSLFGAVIGRSRRLRVEDIDDDYLKTGWDSTEHGFIQSYVSSDTPKSGNSWIANQIWGVEVIDSVRRYVRHVFFTGPQGEEIRGRLVYDYSECFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF15</accession>
    <name>A0AA38JF15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1157442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF15"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041320">
        <property type="entry name" value="CxC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18802">
        <property type="entry name" value="CxC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC1-like cysteine cluster associated with KDZ transposases" evidence="3">
        <location>
            <begin position="140"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="603"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="945"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3725522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113675" checksum="07C2D222E23EC30C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF32</accession>
    <name>A0AA38JF32_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1156532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF32"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3728969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="163" mass="18888" checksum="4FF4A155C8138C64" modified="2024-01-24" version="1">MYVSSEKLGFIPNLHLDDFDYLRDPKQFAQDFKNNPEGLVGVKYRFKCSDGCRRLFVIKRVLYRAEGIIGRGSIVVEVFFPSRSRPPEDALIQDARSKAESTGGHWALNHLTYDESTVQGRLKSHLKEKYEERAMRVVLLEKLHPLSELEDPRDFAQVLYDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JF49</accession>
    <name>A0AA38JF49_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_418654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JF49"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57416" checksum="E6DF0A48879B2FFA" modified="2024-01-24" version="1">MMSPLTSYTLRCELSNHTVWKALQTKTVPQITSVIILPTHKGLSEQLSVPEILPPGFSSGPKADMRTTDQQALVERDLIGALKDMKGLKHFTWRSDAGPVLEEELWSTLKVLGVSSLRIIDHKACDFVGMSGSIEYRSFFESSNFSTFTQLTSLELETRFLAGFDVEDDNEYLQSLIALLQSNAKSLEAFNLTFLDPDALVDVTQILSRLTFQRLREITFRRASCTPQSLSRFLSAHPSIVSLSLSPMMAGRRWEQFSLLADSLPNLMHLACSPFHAARILNGSESSSRPLFCLTGIDVRQVIKLSDYFDVEKQDAYAEDEEVVEVDTYEAEQPITAPWRDELFSKLRSSKQITHVALNENDGPKDLEVLAGLMPQIRWIDVGTKRKDASSKGSWPISLSKFPELRTLHMRGTGLYLDYLPGNKILNTRIENDIRALAQSCPKLMAYEDYGHSVIIRREAKLALEVQPRTEPKDRLKDGLWWPSESFVRATVRKNAGPDQPGPAVLDAGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFD0</accession>
    <name>A0AA38JFD0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1097303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000066">
        <property type="protein sequence ID" value="KAJ3719097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFD0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF18">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041441459" evidence="8">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3719097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="306" mass="33897" checksum="660A8682759DBE10" modified="2024-01-24" version="1">MALPKIFTDTFVFVWDFFLTLTNIVTPNLKAGHVVPSGHPGAGGQWPEYVPPGENDSRSACPMLNALANHGILPHDGKNIPFKTMNETVRSTYNFAPSFCYFVPNYIARILKKDYSKDTFDLAEISLHNGIEHDASLTREDTFHQPDQGKPHIPFIEELLGSASGKDSKAKHGAEDSNDVVLLTSDDLARYSAKRRTEAKARNPEFSLSEFHKAFGSSNSATLLRIFGGRVSDLRPFLIEERIPNGWEPSVQSRVGLTMAVFNLTVLPLEANTGRYMKELTKKSSNVQETTRVGNYGATGMTETNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFD8</accession>
    <name>A0AA38JFD8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tim17-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1132239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFD8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3731704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="216" mass="22522" checksum="F8F0B1AC6E035615" modified="2024-01-24" version="1">MSSDKQISNQASSSRDPTEYLRSATFSKSEGATISPENAVTASDLLLGSYDPAKLHPLADLGDKLDYLLLDDDKTNELPGAGTAIPSRGWSDDLCYGTGTMYLSGLAVGGAWGLREGARRPLAVSNARLRINSVLNSVTRRGTFIGNSAGVLALVYNGVNSSIDAARGKHDILGSVSAGAITGALYKSTAGVKPALSAAIFMSGMAGFWSYVKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFI6</accession>
    <name>A0AA38JFI6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_475937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFI6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="245"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3729989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="389" mass="44357" checksum="EF045AA9F23BB692" modified="2024-01-24" version="1">MYTDDSDDGSDDYVESDSQSRHHHRSKHKRRKTEQGVEFSTEAPHPVVSFQPLLDQVEHLPDDELFQLENSFEDVIGDSLPDYILARKDQIAKDVDRDDFGVLLRRLTRAEITSLINDYSDQVGVLSVPEAIVLRKLKLERERRRAALRGTNISATSDGVVEGLVEFTDTQLNTETVEALGNIRKTSYGSSFISRLYGNHARTPGLMHVDWDTNTPWMNLMEDIREYYQLLHPNRDPVVETRSAIMYTSLQPSHLPQVHDILSRSFWQGIDVSDSLDYSPEKCTVVASYNKMVVGVAIMSSPRETYITYLAVKHGWDSSNIATTMLYLLITLNPGKDITLHVSANNPAMLLYNRFGFKSEEFIAGFYDAYLDPESRASKNAVRLRLRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG80</accession>
    <name>A0AA38JG80_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_477410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG80"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="336" mass="37778" checksum="24722450EA6A4B4B" modified="2024-01-24" version="1">MDSLHPTQKGLCNLPGDSEKVIDADEEVFILYTELQAQDYQSLPSSTMTSFRGLGHVDSHQDIVFLKFPLINPVAGSSSASAASNTSSELESSKSRRRARKKRDTHRPDVIELEIQIAQDKTSLRSRKGDTGSVVWRASVDLASAILQDAHFPPSIHPSLLDLSKLRNAHVLELGSGTGILGVALSPFVHRYTCTDVHDLMPLIHKNLVLNFPEWPHECNISLTALDWTELHRTSLSNRSRFFKFDPVDLLLIVDCIYHPSLIPPLLATIDYMTIPDVTTVLVVVELRAEDVIREFLSCWLNVPAWEIWRIGNGERDIMKRPYAIWVGIKHRSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JG97</accession>
    <name>A0AA38JG97_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1121588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3730020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JG97"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="95"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3730020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="540" mass="60146" checksum="589E846FA9BCB58B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGD8</accession>
    <name>A0AA38JGD8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_684085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGD8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041435118" evidence="3">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3721417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="380" mass="39281" checksum="6A32A6A08E9D8AE2" modified="2024-01-24" version="1">MARLLTLVSLLFFSVGSRVAASSCVAFDASWNLYAFGFNGKDYNAGTSDSWASGIASDITASGRPPFDGSNTTCYLSQFYNAIYVLNGDSSNPSNVHVFDPTAKSWTTQVTSGGPTDGYSAVLDHDTNVFYVLSDSGELWFLSFENITTAAQSSTIAWTDVEKAGFDTTNYQPVMALANNHVHFLNVPGVAAGSADIFVIHFSWFQPDPQSYGNFPAQHGQTTSIFEPANDGVQLAFAYIPDDGSATYVIDVVSNTTTSMAGPSTKDSSAIYFASDAAIVQLTSSGAVNYIPYTNSSSDSSASWSSVKNLVSVAPTSSASSASGTATKSASGSAASGTSTSSSSSSSTSNGASSMAAQSGSVVAGMMSALLLGTIALFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGU5</accession>
    <name>A0AA38JGU5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_992926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGU5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3734709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="506" mass="56909" checksum="0798C9AFA3AA5164" modified="2024-01-24" version="1">MSQQKLEQISLSEPKIDELYRPEVNTDGIDEKKLMRRIDLHVIPWLAILYFLNFMDRGNIGNAKLYGMTTNIDHPISDTQYLIALTVYFFPYALLEPASNVILRRLKPSLWLSSLILCWGVVMVCHGFIQSYGGLVTVRVLLGVTEAGMYPGIVFYISSWYKRSEMGTKIAFFFSSATLSGAFSGLLSVAIHNMNGVGGLAGWRWIFILEGLLTVVVALLSFWVIQDYPEAAKFLTEEERVFVIRRLKDDVRLSAAGEQFKKKYVWQSLRDWKTWVAMGIYMGFDGPLYAFSLFLPTIINKVCILLLRFTATKANLLTVPPYAWGCITTVLVGILGDRIGTRYYMSLFLFATGAMGYIILIASRDPALSYFAVFLAASAIYPSVRDAWVAGNVEGAYKRSVTLGMAIGWGNINGAVTSNIYRSTESPWYTLGHGIVLAYIGIGLICVTIMRIGLQRENARRNRGERDEVIDGIDNKNADVRNGRYPDVETARLEKGDDWSGFRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHW0</accession>
    <name>A0AA38JHW0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_989371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000005">
        <property type="protein sequence ID" value="KAJ3736286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHW0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3736286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="310" mass="34656" checksum="01AC5254FAF4E4FF" modified="2024-01-24" version="1">MKRNLALVSYSSSDEENDSECVSKSAVTKKKKLPSLSSSLIVQTPKDDPALHQGRIRTTPHVDGQWASHVFVSIKVEKRSAMYNLVLDALKAAKNIEPALHDFSPFDGKRSDEYLDLHVSLSRPIFLWTHQRDDLKREIKSLAEKSNSFKISFTTFSVLTNDEETRTFLALDVGSGHHELKLLSDGLLPFIANLRQKEYYAEPHFHASIAWALLRATPTCSKVINEGPDSRVSLTVANLPSPVRNGSPSSTQVLPSTNDFEQILQLPASLTATLNEQYASRLSSKSWSAYDIRDLCVKIGKDVFSWRLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHW4</accession>
    <name>A0AA38JHW4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1147223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000052">
        <property type="protein sequence ID" value="KAJ3723577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHW4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3723577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="530" mass="60327" checksum="34C720184CE41FD6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI09</accession>
    <name>A0AA38JI09_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spindle checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_311245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI09"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="249" mass="27298" checksum="684B7D7BDC9474BE" modified="2024-01-24" version="1">MTTPPASSAFSAPSLTFNQTVRGITEFIEVAIHTILYVRQVYPAELFIRRKKYDTPVFQSRHPALNAYISGAVKAFGTELVTGNLESVVVVIKNKEEKALERFVFSVENMIQVEIFDKDISVEGAMSSLALGQYFRSFLVKLNMIEAQLGQMYLGDDVSFAILMELKDDMKPATASGSQEPPPWIPADQQHTTSGASDDAELHIVRAVSTGIINLSLVVQESDVKLSLISNSEALNSSQGIDKGKARIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIB8</accession>
    <name>A0AA38JIB8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAMK/RAD53 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1068872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000018">
        <property type="protein sequence ID" value="KAJ3733384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIB8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="167"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="692" mass="75908" checksum="BBB7D6009EAC98C5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ13</accession>
    <name>A0AA38JJ13_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_986889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ13"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="210" mass="24148" checksum="78235888D281FA0C" modified="2024-01-24" version="1" fragment="single">ATAIQEAVRTYNTAAAKLSPPREALSYDEVVEKAYVSELDFLKDTDSNIHEKIWAVPANRVLMTEYFKLFRASEELDRLHVEIHRLLTYMKEEQEYLRAVELNISENNPQLAYQVSLYRWERGRFNDLHWLRLRNIISLPGFDDTNRRFFRAGVGLKCQSQGEDERANDNMGEEMDVDRVNGEDDSDSEGEEGDIQAEAQVTAVLGVAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ84</accession>
    <name>A0AA38JJ84_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_547042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ84"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="373" mass="42268" checksum="4D1FF087F6DD9848" modified="2024-01-24" version="1">MCRWVVYIGQQPLMLEDLLIRPKHSIVKQVSERFIPGLYYGLEEDDVEELKKQATWINVHGFGVCWYTDTLTEFDPSIKGMLPAQFRTIAPISTDLAFAQLCGHTASKCTLAHIRDASFPPVVEVNNHPFIFGKYSFMHNGSVDSFRKIRFDVMRRIFDLQTVVQTNQYQSSVQDSNYVFGILGNTDTEHLATLYFAHLDIIRATRPSFGADSTDALLLALIETIADIHTIQFQHQVGPFTPGPGAERVGNALNLCITDGGVQMLVSRWRDSKEGYPRSLYLSLNAGEKLNRKYYPDLPAPTTSEDVNNTDVKIDSVRELVARHKPTQQGRHIIVGSEPCTRYVQDWGLFDQNQFLPIRARARVRRVSVHGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJL1</accession>
    <name>A0AA38JJL1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1039851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJL1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="287" mass="32843" checksum="D83DF9787CB16910" modified="2024-01-24" version="1">MSSYQNVYSLLLSTFRLRQYLLQVPLSYGLTTSVLTQIDSVRNGQGLPQTNSYHDQEFLNLKLLLINGRHHGCYIDLTTLYLNIYPEDQFQGLNTAWSSHAQQSVQQLTGVDELTNLEDKNPSPPILSFPRPLWPSSSLQKHPPSSYEMTPFRPELVELYLNFCRRSESLGLIDYIAYTPSLHPWSMQEWYVRTELFSGEKQHFEAWYWRINVGDTLSPLEPQPISARVVDVPEIRTETNPQITSTQLILAFVSTALRVEKNLRTRDPSEDTGVGSGIKLFVGLFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKD5</accession>
    <name>A0AA38JKD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_466896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000035">
        <property type="protein sequence ID" value="KAJ3730103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3730103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="350" mass="37923" checksum="5AE4AE28B0F677C2" modified="2024-01-24" version="1">MSSSSSPPSYTTEDQHAQDVHNAQASVKRRNSGKEKAKEVGVDSDTRSDTSSVSRRRSRRHSSHSADAPKLTQEIIDRIARQSIRSSRHINADLLKQIARQGGLPKDLAQEGLPKFKVITGSEATKVYEKTLREDDRASSLSHDSSKRRGARHIEQRPIVLAYPGIRAGRKVVDYYMTWKGKTPKAHRLKGTGRRNDILDGEFKSVAKTLDEYGKKAKRLSNIISAGPSTPKTSSFDAEPLTPRASTFSTSSALPDISNAAGNVNAAAELTRPSPLQVESAPAVMTTILPDENDPLSTPRPPYARINSNGSAVSLPYLGDRLPLVVVNPDASSFSGQGLLIIGCMSCNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKV2</accession>
    <name>A0AA38JKV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_326826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000025">
        <property type="protein sequence ID" value="KAJ3732365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="754" mass="82307" checksum="FF89EE2AB68507B5" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMP7</accession>
    <name>A0AA38JMP7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1069412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMP7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="208" mass="22412" checksum="5E2304995D8A6AC7" modified="2024-01-24" version="1">MMTVPIPKLKLNDRSAPPSHPTTPKSFKKGFIKRLRSPSTAVSTTPASSSYYPTYSTFPAQSSLLNPPLPLPDAPLEPPVLPFLQQPLPLPSPALTDDSRIAYTDGLLNPVYSTHAGEASANPVLHAGNDSSLSLGDHVDYSRPFGGFVFNQMDSSTTFTSADTRTMHPAVETPLYQQQPTDHSARNESFNTHIAVDDGDQGSYFPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JN06</accession>
    <name>A0AA38JN06_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_489751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3728965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JN06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3728965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="248" mass="27449" checksum="B01E8FBCE8C24B99" modified="2024-01-24" version="1">MFSTLSPYQDSRPRSDRPVRGQVERTSRSKLMGYSTSRFIVLVVLGLVSFVCAAPLQPEPASTPTTAPTFTLKPSSSSSSSSSLSSSSPSTATARFAPTFFPRTNSKSESESKTFTVRFRDTSSNDNIFIQQPIEKLLAHVNFKVDKFIGYPTTKDELEADYDFDLVDSSGVVKYWGEIWDDDHAIQKVDGNKPGYQYDPVGLGGRLSVEREVKGKVEDIEVFEFRENTITVNELQAESASGKLKADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNM8</accession>
    <name>A0AA38JNM8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_453047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNM8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3730853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="65" mass="6885" checksum="6349D7B77F3D28C1" modified="2024-01-24" version="1">MPENPSSTSKSAANRTLAQSWAALPASTRIKFSLGICAVATAGIYLADVLEKQIPVEQREKNVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNP9</accession>
    <name>A0AA38JNP9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_818830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNP9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041214635" evidence="3">
        <location>
            <begin position="18"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="353" mass="39168" checksum="F9CE8DE371E2C41A" modified="2024-01-24" version="1">MLTLSVFLLGLLCLTHADCTNPTVRKEWRTLSTDERANWLSAVKCLSELPHDTALTPYVNPDDIVAVNASGSYYDDIVYMHMDLNHLIHFTGLFLPFHRWYVQMYENALTEKCGFNGTSPYWDWAADAPDVYGSTMFQDFDPVSGLGGWGNLSNDAQVPNGAFSDFKLSYPSYHTLRRNFTLQPYIGLDPTLFTDPYMDANASFTQSEVDKMVNGFVGDYKGFQSYLEGFEGAHGSVHEILGGDLGGTCPSTAPANCTPGPTFSANEPMFWMHHAMVDKVWYDWQNSDSANAGIFYGGSVQMIDNATIYAEYPNGGPPMLSLDSVMHADGMFEENTVGDVINTTAGILCYIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNR9</accession>
    <name>A0AA38JNR9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional Coactivator p15-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1056659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNR9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3735717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="152" mass="16964" checksum="C6B2FFF5214C5551" modified="2024-01-24" version="1">MAKRKTDQERDDSDSAGSPVVPLSKPKLGRGVKKPKIMMQEGSESEQGEEEEEKHPKKKEKSKPVPSSSGAGRSVEKNHEGDRYIDLGKKKRATVRSFKGTTFVDIREFYGDSEESMKPGKKGISLTPEQWEVLKNGATIIDELFAAEQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPA8</accession>
    <name>A0AA38JPA8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1065760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPA8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="109" mass="12692" checksum="FC1F5203A3855BC3" modified="2024-01-24" version="1">MLRFLAKQPLRTISTSTRRCNQKSTELDDFRPAWLYTFARVASNISIFGIMTYAVFFYDFGNDEHVFQPVRRWVSRQKTTLFALSPDEEKFVESEKRKAEAGGSPKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPQ3</accession>
    <name>A0AA38JPQ3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1223114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPQ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041334958" description="TM7S3/TM198-like domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3733855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="352" mass="37988" checksum="022D4FEEE33AB0A5" modified="2024-01-24" version="1">MTAVARPHLLLALWWLLSQLTAVVLAKPVSPIAPDIYARKTDPVVSHSLNGSIIILDPSTQQTIPQGPGTDGCGAGFSFPAIVWIVFLLVVGVPLAVAGIRGWRCTTGVSIGLAVIDAFSNVYFHVAWAAIINSVNEVGISDILLTLIVLAFGFLGLVIGFFEFARIVAMVILCLIGGLSFGMRITLLKTDLLFASVGLNWLIIVIFGVAGGLLLIWKNRIAMLIACASSGTFLTSLGIDLIFNQQSGLSFGLRSLFDSNDNHLAYFLETTYEPTLSTRIIVIASLGLTPAFVYAQHLLFKQPFTRRGPSPSDEELCLNYPTEDFSANRATAFFSGIWDGTKLKLSSSRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPT5</accession>
    <name>A0AA38JPT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1155652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPT5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF420">
        <property type="entry name" value="NEMATODE CUTICLE COLLAGEN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="336" mass="36132" checksum="42FF17D37EE23B59" modified="2024-01-24" version="1">MIYDSLLGLCRIGTPGELPPGTPGELQELLGNSRNSRNSWELLEFLETLGTPGNSWSSWKLWELLETLGTLGTLGTLGTPGTPGTPGTLGALGTPGTPGELQELLGNSRNSWGTPGTRGELQELLGNSRNSWGTPGTPGELQELLGNSRNSWGTPGTPGELLGNSRNSWGTPGELQELLGNSRNSWGTPGELQELLGNSRNSWGTPGTPGELLGNSRNSWGTPGTPGELQELLGNSRNSWGTPGTPEELQELLGNSRNSWGTPGTPGTPGTPGVPGNSGNSWKLWELWELWELLELLELLEPWELWELLGTPGNSWNSVQELFRSLYISHQFPNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JR82</accession>
    <name>A0AA38JR82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_874293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JR82"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27360" checksum="0B80E3999AE9D748" modified="2024-01-24" version="1">MFSPFDLPEDIFLLITDELPSPADFALCQCLVSHIKEKQNSSPRVVLSVSESLTRWQSILAKSNVNLSQQIAAKTFHFIDITSMALVQTDTDKVHGNPFHALYEQISSILEEGKRDLSPGALVVLDDISSLEWIGFSTSDLLRLCRALRALCLKNQATLIIRHHIVTPGELDPLFRHLHSLCTYHLDIQPLNSGRSGDVSGQIALHSGPNAFPQSAVKTRQRSAALQYRLTDGTAIFFERGSSRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRD2</accession>
    <name>A0AA38JRD2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1076074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRD2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="78" mass="8176" checksum="C3B2BC9752B38885" modified="2024-01-24" version="1">MSQTTHTTSINNYFQVPGRDPAALSFEESSTGPSDKVVWTVVCKVNGQTKGTGSASTKTEARNLASKQALEALGQSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSA0</accession>
    <name>A0AA38JSA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_129113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSA0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3734496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="510" mass="57235" checksum="08A967A0397DBBEF" modified="2024-01-24" version="1">MDALFVPLAGAVGASIDQVKLISCLLIAYPLGSVFVRIPADRPNLKHLFNISVSLFYFFPMLGMYTGFLQLLGDILITYFAAKFSSTSKVMPWFIFLFILGHLMFNHIIRVIYDLSYETIEVTGPQMVLTMKLTTFAWNVWDGRRDEKDLDKWQLEKSVRVFPTLLEFLGYSLYFPGVLVGPSLEFADYMNLVHERTFTAPGKHEGGRRLPSGRKRVGYRKMITGLGFLGVFVVFGGSNNYSVMVTPWFAEQSWLKRVLLAQLYGTCERTKYYAIWTLTEGASILTGYGFTGFTSTGQSTWNGAANVIPTVIEFPSNFKVLLDSWNMKANVWLRECVYKRITPKGQKPGFWSSMLTFATSAFWHGAQVGYYLTFLMGGFITSAARLVRINFRPFFLPAEGQSITTAKRLYDFFGALISLLVLNYVAAPFMLLTWENSITGWMRLGWYGHVIVLGSLVFFYAGGTGICRSLQKKLGLTAKKVVSTSGSATPVAEKTFQVAPALDKVIPPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSV4</accession>
    <name>A0AA38JSV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_991417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSV4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="7">
        <location>
            <begin position="83"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="8">
        <location>
            <begin position="202"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3735445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="311" mass="32713" checksum="51C8EEA913E42F85" modified="2024-01-24" version="1">MGYTLCVLGCGTMGIAILSGVVDSLDVSRIPNNLEKWESHTPGTVTPTGSPSDNTTPSRFLACVQREVSAVKLKGVFASMGVLAQNIEIFVSQNVQAVQQSDVVILCCKPQSAHSILSEPSMQKALDGKLLISILAGVTISQLSSWVLPSTKVIRAMPNTPCKIREGMTNVSTIPSSASEALDAAIILNIFSSIGRCRFLDEKHFDACTALSGSGPAFACIFLEAMADGGVMMGLPRAEALELASQTLQGAARMVLQGQHPAQIRDAVTTPGGCTIAGLLALEDGRVRSTIARCIQVATERASELGQPNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTF5</accession>
    <name>A0AA38JTF5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1212099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTF5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="310" mass="35103" checksum="F4E0D8F5AD7D50B8" modified="2024-01-24" version="1">MNRIPRFKLNNGGYMPAIGIGCWMGTVGDSQQVEEMVLTALRLGYRHIDTVRNERSVGKAIRASNVPRSEIFLVTKLSSEDHDKPEEALQRSLGQLDVDYVDLYLMHWPQAFDTDHARYRSPEESPTFIETWKMLENLVDTGKTRSIGVSNFSIKTLEILLKHVRIVPATNQVEMHPYLPQHDLLSYCSSRDILLTAYSPIGKYKFATDPSVLEIAQRIDASIAQVLLSWGVKRGTAVIPKSTHELRMKENLTLIALDNEDMQILDDLYRQPGMHRSVCGFHSSELGGSCFGWTYAQLGWDMLEGGIMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JUM2</accession>
    <name>A0AA38JUM2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1148995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JUM2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041482615" description="Hydrophobin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="109" mass="10715" checksum="93DA5E305D8E3FE9" modified="2024-01-24" version="1">MQFKLAFVTAVFATLAAATPTPRTEPAGSCSTGPVQCCNTVESANSSGIAGILGLLGVVLEDLDVLVGVTCSPITVIGASGSSCSAQAVCCEDNSHGGLISIGCLPVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWE7</accession>
    <name>A0AA38JWE7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1185141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWE7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="57"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3736881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="730" mass="79529" checksum="794FCC30EE11D8DB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JXN8</accession>
    <name>A0AA38JXN8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_987248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JXN8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="203"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="368"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3737511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="46450" checksum="E2A69AA83E540918" modified="2024-01-24" version="1" fragment="single">MDPPFVSSDSPPLRSTILGSFLGRGRPRNSSQSHANASSPSADPARRETSPSPNPPSPGGQAAGSNSHRRARPAGNAGPGNATTAISAEVGNGVQPSTSAPGAGLAFSMLRRRRSAGTMANANNAITAAALTMPAGASSRPPTAPSAATNNVRSISTNTTAIRLPAPSNSPSHRLRLVPHLESRRSLRFDAITRDMRIGDPVLRIGRFTDRSGNSQNGGGVNNNNPSSFKLAFKSKVVSRAHAELWVESSSPSLSTTAAANAKFFIKDTKSSSGTFLNHVRLSPANTESRPFQIKDGDILQLGVDYQGGSEDIYKSVKIRVEIGREWQSGANKFNTTAIKNLKSLAQAVSQSANPGTSKPKSAGIPDCCICLFPIAINQALFISPCSHTFHFKCIRPMVEAHFPSWSCPLCRSFADLEEDVEVEAEMDFEIEDKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYK2</accession>
    <name>A0AA38JYK2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1058431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYK2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3735143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="299" mass="32469" checksum="7603CB6EE1E30DC1" modified="2024-01-24" version="1">MPLGPPSSAIHIQPAVSPHMQNAPRTPTSITIHPVALFSILDHYLRRKDDQDRVIGTLLGTRTDTHVEVRTSFAVLHSETSEQVAVDMDYHRAMYDLHHKVNPKEVIVGWYSTGSNLNTYSALIQNFYSQETAPHQAIHVSLDTGVEPGQPAGVKGYVSSPVGVFPKPENCVFVPVPVELRFRDSERSGVDLLTSTALSSSSTSSQPLSDLTILESSIQNVISMIDRVLTYVRAVLAGEAKGDAAIGRYLMDTLGASTDDLEKGGFNGRLQDTLMISYLANLVRAQAEVSSRLALVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1C7</accession>
    <name>A0AA38K1C7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1048471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1629"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1670" mass="180013" checksum="053FC9AC97B6F0B3" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1X0</accession>
    <name>A0AA38K1X0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 95 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1046917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1X0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF3">
        <property type="entry name" value="ALPHA-FUCOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="70"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="341"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="2">
        <location>
            <begin position="782"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3737273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="862" mass="93574" checksum="9250BB8D4EAA708C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MR38</accession>
    <name>A0AA38MR38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1043362</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MR38"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3716346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="478" mass="53364" checksum="4B355DF8C66A13B5" modified="2024-01-24" version="1">MPRHVPVTDNFPDFAGHLLDNGRFKLIEPLGSGAYGKVYRAIDLTSPCENPEYFAVKCLLRPKPGSRQEDFQLREFALHRIVSTHSNIVGFHKVLYDRTFVYVVLDLCLGGDLFAAITERKALRQNNELIKSIFIQLLDAVHHCHENGVYHRDLKPENILCSQDGRKIYLADFGLSTQSKVSEDFGCGSSYYMSPECIGKEFKHDKYSTRHSDIWSLGVILTNMIAGRNPWRYAMTTDDCFSAFLYNRDFLRSVLPISDQANLILKRIFHLNPFNRISIPDLRREILDSELRRSSDVVRAAAANYAAPPADPPNDALERPKTPVVAAESVPSKDSSYAPKDSEEVYLYARPTEGLRPLRDHPHNSLLDVLAVGSSKDVTSASISEPESAGPITPESRPVDEPLVEVPELSEEVLGGGPNVLTYKVIQAAAKTDAKNVQVPRHRAPSNTAPKPPPRRVGKQLLRRAVQRLKALSESVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS88</accession>
    <name>A0AA38MS88_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1002861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS88"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3724957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="246" mass="26686" checksum="0964D6C814FEB0B1" modified="2024-01-24" version="1">MSYASVAGSNLPPSQPRPDPALLNTEIPAASIVADDTSKVNVVHPDFKAHPATVYSENRPPPDDAPSRKKYSNRRLREAEAEGLYLWQIAKHYLFRPGVAGGLIGIINIGLLAGASRAFYTQPHLRSDRKVIATTAAATLAILGVEGFATERYAQTAQGQSEARRAKEEGTLIYKHLRENILRPGVLGGLLGLVNAAVLGSVGYFSYIHWDKPTWDRRIVSAVSVGLLTLWGGEGALAERYRAAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSH9</accession>
    <name>A0AA38MSH9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1087120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSH9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3727215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65389" checksum="8EE4D78C0684A7FA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTJ1</accession>
    <name>A0AA38MTJ1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1132171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTJ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3731924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="639" mass="71222" checksum="1A32805BC2307A3B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTZ6</accession>
    <name>A0AA38MTZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1073758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTZ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="200"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="374"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="469"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3732404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="589" mass="63011" checksum="453F60BC1D57EEFD" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUJ5</accession>
    <name>A0AA38MUJ5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1153504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUJ5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="205" mass="23225" checksum="DB5ECB4E35DAAD93" modified="2024-01-24" version="1">MLTFFGAHSTHSPFYASKFYFILICGFLFSVLFATSIPVALSESLDPPILDTRDDMPITRIASVEFTGKRKYRTTQEDRRDVQGYTLMFLHAVLPVLDQNALSIIVEHSSWVTGPKQSNPTRTNPEKFTMTLKPLSWGLANLVKKPTVYTAYFWLEEGVVNGYLTIPSGKGRFSSEARKKIIGDETTIAELRANKLRRIRRTLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUN4</accession>
    <name>A0AA38MUN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1009250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000138">
        <property type="protein sequence ID" value="KAJ3710506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUN4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3710506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="327" mass="37418" checksum="7E969DAC5B937459" modified="2024-01-24" version="1">MKKPLRYKRVWPKHARDSQPSTLFNSDIHSSSVFHQTPTTDEIKQQSNRNIAYLNLSSAPVLGTGHHSIVYRGALQLPSPLNNSSLNPCVSVATKMAFIRGEKRELIEQEGRVYNAFPEYLKTSYSGYNLVPPIAHPVPAAACVPKFFGYYVPVNEANEAKLREADLSALAEQERRWQPVSSLLLVEECGKDIVASELTRDERNECFTILLRLHHANFIHRSFYVRNFLKQPGPLTKPPQERSISSPSFRLIDFGRTRIWRDEMEEALSKYSPLKQSRTISDVSTEGIEGEEQKKMKLKNAAQEWFTDSNYEVGKVFRELEIPNYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MUN5</accession>
    <name>A0AA38MUN5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1165483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000102">
        <property type="protein sequence ID" value="KAJ3713031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MUN5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="538"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3713031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="906" mass="98906" checksum="6A3545943C6F8304" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVB0</accession>
    <name>A0AA38MVB0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1064555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000014">
        <property type="protein sequence ID" value="KAJ3734294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVB0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="283" mass="30998" checksum="C79A0D4363001B32" modified="2024-01-24" version="1">MASDIEEPQVVLITGCSTGLGRCIAEEALARGMRVIATARRLSTIEDLRDKGARTFTLDVNDKPEVLQSFAVDSINAFGQVDILINNAGWLLGGAIEENTPEEIQSQFNTNFFSVISITNAFMPHFRSRRTGTIVNISSQGSYLALSGAGIYCASKAALDCLTEAWSNELAPFNIRAVSVILGAFRTSVASSNSKAPTKTIEGYDFAHDFHKRFQERSGHELGDPVKGAKKILDLVTMKTEKPLPVRFALGDDAVYLSKQHLEQRISELDEWKSYGMDTNVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVK0</accession>
    <name>A0AA38MVK0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_993426</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVK0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="95"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3734564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="166" mass="18153" checksum="49FEB4E844F55228" modified="2024-01-24" version="1" fragment="single">NKAVVTALSASCISTFAGYPLDSLKSRLQTTKTPISVPRLALTVYREEGISGFYRGLAIPLLTISFVRAASFTIYNSTKDYFKKREWLARDSIVDVSIIGGISGAMSGALISVGSTPFELVKVRRQLEFSIASSKGIHLAKSPRTLEAVRDIFRTSGIRGLYTKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MW54</accession>
    <name>A0AA38MW54_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1095896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000062">
        <property type="protein sequence ID" value="KAJ3720280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MW54"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3720280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="297" mass="33049" checksum="B24969C44C7AD769" modified="2024-01-24" version="1">MTLLNGEGSGQPEPVKLLGNGVTLKIIFSSSGWLHCNLQYFPLFALTSFLSQNPEMAIKIATEQEKVKDTVKARDAAIQHLSNAYISIEQKLEIIERLEKQSSSEKSFQKHGPSLEADKLNHETAGFEDLVDDLWKEIEVLKDAPPQYTPDSATMPESLQLNPPALSAMSLAAVCDMSQKTILEIEEIDLNLTIIRTSATREDAEDIINARNRLLAALPLPKEAPDDALKPIAIPTSHVNLYEFLASVPGVSSPSTEFLLSNYRVLHQVTTSWCPQREEHGYYLTPVFKCTTDLRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWA0</accession>
    <name>A0AA38MWA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_991301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWA0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="4">
        <location>
            <begin position="188"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3735494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="277" mass="30215" checksum="C68F3DAA81CBF25B" modified="2024-01-24" version="1" fragment="single">QFRKTVCHVSTNGDTHFEDLSDVHEIEVSKGWTRFVKTGVPNGGYLSKGLYKYGILARFNGNQVALFTHKPAGSSNNLNSTALHDELDLLVQGDAFAKSFKNRALAANVKLPGDHFPKHACTPHLITVVDLKYNAEGAFVGTVTVPLPGSGLPIDDETIEQEAANRSLLFDTFLVVPLLQTKGLFSERKFSGNTDTGENSDYVGKVVDAFAHHVVEETNGHLMLADLQGVVGPDRSIILFDPQAHRQVVFFISSTHVADYMIALEAAQVNGTRGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWG4</accession>
    <name>A0AA38MWG4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1094283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWG4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041432695" evidence="8">
        <location>
            <begin position="26"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="136"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="167"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3721427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="458" mass="48986" checksum="90A2132844197DCB" modified="2024-01-24" version="1">MASKTTHSFAASFSLVLLVLSCVSAVPLAREQPTGGAISLPPRVAPTNPDGTFNHDAAKRLNRRVIEKHRQNLMNLEKNCGGLPEGIKIPDLAAVPQNPAHVPRTDEDSNDKVTHTKRTSKKAEEGLTDEEGDVEWAGNIEIGTPSKKFLIDFDTGSSDLWVVASSCTDGPCAKKNKYDVAKSSTSKKESGTFSIVYGDNSTVSGPISTDTVTVAGATAMNQTFSAVTTLSKSFADDPTDGILGLAWPAISNLKAKPWFLNAAEQGAVKKKEFGFYLSSGNGSQLYLGGTDPELYSGSLEYHKVDPSEGFWKVLDARIHVGGKEAVKDFQTIIDSGTTLMYGPPAAVKEFFSKVDGASVYDEQEGFYSFPCDKVPQVSFSWGAHGKKFVVPSENFNLGQTEKGSSSCVASLAASDLGLGNAWLIGDSFMKGVYAGFRFGEKDITKDAAVGFAELKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXF5</accession>
    <name>A0AA38MXF5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1157834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXF5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3724306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="448" mass="50355" checksum="682ECE029952EBC0" modified="2024-01-24" version="1">MSTQFLQFCTPTQANVIVGYDYMATSKDHNLDEQIPQSYPVSTQFAPIFSPSLEYHGPDSTQSSQNPLKSSVRPLAPRKGSPRRETHIPRPRNPFMIFRSEYHAQAKITTDVERDHRHISRIVGYLWNNMSEEDKAPYRLAAEKEKAEHQRKYPGYRFCPGTRTSKPVKRKVKRNGQNDLARSQKVAELLKAGLQGRDLESAIKDIDFESLEGSSPPSEGYSPSPSSSPSTQPSPTLPDVRGWQHDPVPAGHVFRSPLLAPLSTSSTLPVRPVTRRTPERPIMDSLRPDPPVTIPETYHMPSSSQPSASLMTPTYQEAYQTLNSNVELDAQPYQYHSISNAYDTYNREPQFAQYYAPPISSYRDQTSTTDSYVTPASLGLYSENVSSNIPVDMPFQYYENSSAFFGGQEDTFSGIMNEFGLYESPVGQAPDPTTSFTWDPALQLFVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXL8</accession>
    <name>A0AA38MXL8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_580223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000046">
        <property type="protein sequence ID" value="KAJ3725587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXL8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3725587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="318" mass="35511" checksum="EBC9295EB84F1A03" modified="2024-01-24" version="1">MASIVLKRTNQKMPVVGFGLWKVTKSSCADTVYAAIKSGYRLFDGAGDYGNEKEAGEGVRRALSEGIVKREELFITSKLWNTFHAKEHVNKIAKKQLDLWGLDHFDLFLIHFPIALQYVDPSHRYPPEWWGDDGKTVTLANVPMQETWTCMEELVDQGVAKNIGISNCSGSIICDIFRYARIEPQVLQVEIHPYLTQEPLLKFAKTLGIAVTAYSSFGPQSYLELGMDKGVTALFEHDAITSAASKVGKTSAQVLLRWAIQRGMAVIPKSNSPDRLVQNLQSEDFELSEDDMKAISALNINLRLNDPAEIDPRMAIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXS2</accession>
    <name>A0AA38MXS2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_685084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000058">
        <property type="protein sequence ID" value="KAJ3721428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXS2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041338957" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3721428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="157" mass="17574" checksum="2D9F736BBF4700E3" modified="2024-01-24" version="1">MFFRIYLILILGLVLVHNAAATPIDNSKGDEPKELPLSKQLKLAMQGPSAFDVNKIQVVFIHEKNGESLSNMVGFIKAAIGDKIQESTHQKPSFVVYPEPYLIPGQKVIRFKFKKAEDESHSEGHVTFSDNELSIDSEVEVLLTPFYPTIKVTPPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXW3</accession>
    <name>A0AA38MXW3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_584883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXW3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3725036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="198" mass="21705" checksum="07235FE70310C364" modified="2024-01-24" version="1">MTPPSSLAVDEGKRRSSMDKTKVSHLSRQLQLRLQYAKLKVEHGWHKQNLNEVENLYFRRTNSRPRQQSAYGPITQTSYSSTNNAQPLAPQTLSFKAHAFSSKVSESEQVRPHNSSAFPSSLSSAVIPSVHSATPPIAVTPNDAQSSSQGANNSPAQTSSLLPSPHIGPTFSPAVPMSLHTNSSNVWIPFRTINRISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXX9</accession>
    <name>A0AA38MXX9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1093191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXX9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3722126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23799" checksum="CD07A8B7F5EECD3F" modified="2024-01-24" version="1">MTNGITNLDVFTLPDHKHNRIKNRMIKIVNISEPSAACERYALQIFHEYFRTGFAIIDGQKVGVIITSMGGNGASSMRRTTWWKDLSLDHKSYALNSTRKVVQEMVFEFLLEGKPLYANFSPDHVLIDNNQEIHLIDFGYPGVRPMKLLPKPDEYEKWFQRRWYFLWEDVYREARAEIPVEHLWRKSEPERKGPTKMSPHMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXZ7</accession>
    <name>A0AA38MXZ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoenolpyruvate/pyruvate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_539211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXZ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3727276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="262" mass="27589" checksum="4B2EA5E4187A08EC" modified="2024-01-24" version="1">MSLSIPLRQKLSAGEQAAGAWLTLPSTAIAGTIARTPNVSWVLIDAEHGLINDTHLYDLANTIAANGASPIIRVPSEETWLIKESLDSGAHGLMVPMANSAEIVRGIVRATKYPPIGIRGFGPMFTSATGALGGGYALAANSELVISVQIEHPQAVAEIDEICQEGIDVVFIGPFDLALSMGVQFGSEEHETAIAKILATAKKHGKIAAIFCLNGEQAARRFAQGFQMVSVTTDIDTITTAFTHELSMATGKTTDAAKGYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY17</accession>
    <name>A0AA38MY17_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1092918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000055">
        <property type="protein sequence ID" value="KAJ3722725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY17"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="745"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3722725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="860" mass="87894" checksum="05B723FABF1773F0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MY75</accession>
    <name>A0AA38MY75_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucocorticoid receptor-like (DNA-binding domain)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1001048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MY75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3729032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11898" checksum="132A86902F0610D4" modified="2024-01-24" version="1">MGLRPNIRVLRDMKARQGVLDNEVTRRAYLFVARNQNLPPQIRHQAQLQLNTFGRYTRPTTVKNRCYASGRGRGIMSEFGLCRYQFRLKALAGMLNGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYJ2</accession>
    <name>A0AA38MYJ2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1089771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYJ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053161">
        <property type="entry name" value="Ulvan_degrading_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36848">
        <property type="entry name" value="DNA-BINDING PROTEIN (PUTATIVE SECRETED PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36848:SF2">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17132">
        <property type="entry name" value="Glyco_hydro_106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041243807" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3725080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="110067" checksum="A5E077203D3FF609" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYS6</accession>
    <name>A0AA38MYS6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1045914</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYS6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3737714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="384" mass="44095" checksum="67AAFF71FBDC2FCF" modified="2024-01-24" version="1">MSNDEEVAVSKNKSHRKDKRIWKIDPFLPADNKAGTFAEESSFATLFPKYREKYLREVWSAVTRALETQGIACTLDLVHGSMSVRTTRKTYDPYIILKARDLIKLLARGVAVTQAVKILNDDISSDIIKIGNLVRNKERFVKRRQRIIGPDGSTLKAIELLTQCYVLVQGSTVSVMGPHKSLKEVRRIVLDCMKNIHPIYRIKELMIRRELAKDPKLATESWDRFLPKFRKNHLKTSEKTAKKNERLETKNASRKAAGLPEESLADVAAKKKVYTPFPPTQLPRKVDLQLESGEYFLKKHEKDARESAQRKQKQAETTEKRRAGRAEAFVAPEEDAAPTVEEKRKRKRNDMELETAQKEEQVKGTKKSKKKTKSKHEVEEEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYX9</accession>
    <name>A0AA38MYX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1078900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYX9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041334673" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="145" mass="16041" checksum="2D48C3D1DC992666" modified="2024-01-24" version="1">MHLNLVYVLLAVLGMTHITTAIPVQSLEHSDSASTGSLTERKTILVSFGNLAGPEGTEENEAVTRMIDLLFSEAHEKTNGVIPPVRLAFKNHVKKGMKDDAVVAFTFTGLDICQGECEAQADLFHRISFIQDSRRKILYNRHFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZJ3</accession>
    <name>A0AA38MZJ3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_356181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3732015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZJ3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="381" mass="41699" checksum="C80AD194306237F8" modified="2024-01-24" version="1">MTSKVKCRFFDQKTGKRIGTGCLRPDCYFVHPSDRGWNSAKSSDYRAESEIKDKQMERDRGRDRDRGGGRNRERQREWDRDRDRHSRARDRTPDSSSSRYSSKDAAWGRVQGSKSFDLPNNSGLLTRKRSDSQLRASTSDRGWGYNDITSNHGIDSVSSNNNDASALGWGSENGAGQNSNEKKEGEGGSGSRGWGTGKTSGWGPAEQGSWDATTAESRKSTEISSSALDKRKGKERSPPAVLSYPPPPPPINSWNASSSLKRPSVARKASAERSPSPFTPSTSTTPNVFFPAFSREPARKTSAVAAKLIPNAPQAFKQRVSGQSPREDSGGRISSPTPVADVKNSDPLPRSTSPAITERTSISVSFSRKTLKSRRVRKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N0L4</accession>
    <name>A0AA38N0L4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_995989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3732975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N0L4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="10">
        <location>
            <begin position="92"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="9">
        <location>
            <begin position="299"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="834"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="918"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3732975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1044" mass="110243" checksum="0A27346AB8BC0980" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N139</accession>
    <name>A0AA38N139_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-galactosidase</fullName>
            <ecNumber evidence="9">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1067886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="9"/>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N139"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3733590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="470" mass="49874" checksum="37CAECAC8009DE16" modified="2024-01-24" version="1">MHFPALQASLALAQTAPDYGQCGGLGWTGATTCESGWSCVVSNLYYSQCVPGSSGSSGTSTSTSTASTPSLTGIAATAPTTPPSKLTGMLPALGWNHWNAYGCSINETKVVAAANDFISLGLKDAGYEYINIDDCWPLMQRDATTQQIVPDPSKFPNGISGVATQVHALGLKMGIYSDAGTATCAGFPGSLGMESLDAATFSSWGVDYLKYDNCNVPANWTDDYAPQDGDWYNSNSAIRYRQMGAALAEQSSPFQFDLCIWGAANVWDWGARVGHSWRMSGDSAPTWQYITEIIGINVQYLSSIDFFSHNDMDMMEIGNGALTIEEQRTHFAAWVFLKSPILLGTDLSLLNSTQITIVTNPELLAFSQDATIGTPAAPFNANASMPTTSIPEYYSGKSSKGVHVFVINTSATSATKSFAIANVPGLTGSGPFIVHDMWAGADLAGTYSLSSTFSVNVASHDTVAYRITSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2C8</accession>
    <name>A0AA38N2C8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1070151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2C8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="140" mass="16250" checksum="5F96504BFDD3D5F4" modified="2024-01-24" version="1">MTMASNPPFVLHEYKHQHPERSQHGPRLPPIPDLRFEPSYLRSIQPYIRLRTLQPGHKSTVKKGADSKGRVDQEDGGTKQKIEQETVDVDWSQVLWVTARDQILSPLFQGALWALITFYFTPYSRRFTDAIVQHLPSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2H6</accession>
    <name>A0AA38N2H6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_992328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2H6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3735045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="537" mass="60209" checksum="00B07508D64487D7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N2V4</accession>
    <name>A0AA38N2V4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1113159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000008">
        <property type="protein sequence ID" value="KAJ3735585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N2V4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="925" mass="105814" checksum="6DBA6A95941D4BF1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N323</accession>
    <name>A0AA38N323_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1152144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N323"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="155"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="412" mass="45448" checksum="6468ADF7FA95569A" modified="2024-01-24" version="1">MVSSTNPKFKQLRVAVVGGGLGGLSAAVALRRAGHLVEIYERRDFNVEVGASISCAANGTQWLREWDVDIPDMKPVILMKLVMRDWETGKILNQYNLDHYEEEWGNVYNMLHRQDMHATLLKAATSSEDKGTPCSVKIDHICESVDPEAGTVTFKNGVTVKADLIIGADGIRSVVRGQIGVVPDMTSAPQTCYRLNVKKSVVDELGLVKYSYDPAIQFWGGFMPTELTKHHEEGFVFEEVPVSDVIAGKYDELDPDCINLLKNSVDRMPWRLYVHQPYDRWFKGNTCILGDAAHPMMPHQSQGACQAIEDAAALGIIFSEKYNFTTDVTAGLAMYQTIRKPRATRVQSASARATENLNERIGFTSLTPHDASLAAAEGKLTINEMNSYKMHSHVASEVEKLGAGLGPTIAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N516</accession>
    <name>A0AA38N516_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PalH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1109983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N516"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="63101" checksum="06A03E6F0A6F6B4B" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J1V9</accession>
    <name>A0AA38J1V9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1034488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000106">
        <property type="protein sequence ID" value="KAJ3712745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J1V9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3712745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="472" mass="54336" checksum="370FD85DCB6817DF" modified="2024-01-24" version="1">MASPSVSSTSSSADSRVQKTFDLVNWDNLSALACTHVQLPKGTGCHWEEQFSGGYNLVRFLHLHDPQKTVIVARVPLLSEGAMSDDHDSAISNRIESEVVTMKYVETRTTIPVPHVFHHNARAEEDVRSPYILMSKVDGVPLSSVWDDMDDDRRRIVIQQVIDILHELWSHRFDKKGALFDESDGSLCIHSSSLFVDPEDTGTRHRLLTTSYSHAADYWLAYANAQLRDIDESNFGSDTKPYIHSQAWFMRSLIPALFDPSIDIHGCPLSPGDFHSQNIMITDIISSHPRITAIIDWEFSGPDFASSFAQYPLFIVDHPHWDSDHPLRERNVRDRVMFDELILEAERNRNPVDDLRLSRLISDSYGIYLFHQAMYFPGMYSSVYPLLFAYVFGDDEDFSTDYYWALMENGILKRDQKRFEQEREVWLEVCQVLGEEVVGVNMTRTEFRDLVSKSREKFDKEGSVCRWFVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2B6</accession>
    <name>A0AA38J2B6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_117079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000128">
        <property type="protein sequence ID" value="KAJ3710911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2B6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12937" checksum="96F7D47E26C0CD18" modified="2024-01-24" version="1">MFQFVYPKRYPALHKLNFEALMLLAEAAEKYEVFALINSCEFCLRNFLNQHPLTILDFAARHDYRSIVEELAMILVDTPMTDLTDLHPQSSNLGCVGQLNLMCHSQIQLNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2P6</accession>
    <name>A0AA38J2P6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1103872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000091">
        <property type="protein sequence ID" value="KAJ3714546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2P6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3714546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34471" checksum="5CCE8C1AF5848DF5" modified="2024-01-24" version="1">MRFSSPRLSSLLSWPLSENSTIASTVYAPLVVDEARRGEENLFLHNHTGQSKKHALAKLAFSVLIFCFGLLLGILVARFPQKGILQCNVPVTAESKTSKTLLYSPAQDAVRYEVRYFNASLRTDITNYQGTPTEDIDKNWEDLYRCKIIQNVPINCAKSFPIFPDGIVQIPASEANKLVDKTLPIPGDDGNYIVTLEVFHQLHCLNLLRKSLYPDYYSTTLIDHLDHCVDILRQALTCTIDINPLSWHWYEPRQATETKLNGAHKCVDFGKIQDWAYEHKLQTPFDESVNLQLGHDHHEHTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4S8</accession>
    <name>A0AA38J4S8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1042254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4S8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34409:SF1">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34409">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3722086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="500" mass="54809" checksum="E3D1F271043DB92E" modified="2024-01-24" version="1">MSSPKPNETSAHPKTPAHDSHATHQPYVSAQPYGYLFPPPGLPHPQQQVGHPIMPGGPGSGALLNHFGSATPAPVHGQPMDPKSVPTRPRPRLLPCMNRADFILPDEFGSPFNTHTPSYRAPPVPPPLSPEIASVGGGGNDSTKAKTKKVDKKVVVKPKSAVKDDNNNDSNDDDELGPKRGRTKGSSQYTDKERTEIIRLIGKFLPIGGKSWDALADSYNSWAKKNGFPERKRPALQVQWGKIHKVAKIKPTGTATRPQILVDACAAGSAIEKKVALGDLQDEDVEDINVDDEEDNNEVLTITSDSDEDTNQKAAKKKGKKLAVGTVLTKAYKTEAPLRPTSRKTQSTNFLEKISLTLDPAAMQQRDENRSSANFQLLMLQSYQSQITTLTTQVNEERRRADDAESELRMLPTPHVQAVLLYAMNGGAGGTTEKLNILQLALHMLHIINVHGAMHIQLHPVLDGIAIRILSIHAHLAINHQKFQWCLFMMKLNYLPSIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5S3</accession>
    <name>A0AA38J5S3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1042359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000059">
        <property type="protein sequence ID" value="KAJ3721330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5S3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3721330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="403" mass="44584" checksum="5888E3AFE38400E9" modified="2024-01-24" version="1">MASPSTEAQLKSEIERLTASINLHKSNTSTHPATGFRKNTYVNPNYKFTNKYIRPTTSTTEPSRSSIQPPTSSAEVKEVVLNGIAFQSSGRSLVRKDLPQTLFNTPASTTTAQPPYVRKSGHMLTGKRVYKPKISRGRRKGNMTLTNGRRPYQSVCLLAPNTGYQLTFIRTRRASKQMKYSDKQCPRFSTTGSCSHGLTCMYQHDPSKIAICWNFLQDNCPNTADTCNLSHDPIPERTPLCLHFLNKGRCTRPNCLFPHVNVGARHGICRDFAVLGYCGKGLDCDKQHVRECPDFAEKGACSTKGCKLPHVIRANRNRKPAQISVLPSGLSSSIVEAGSVDAQGESRMQHVSADDAQLGDEYISLTFNESESEESDDEEDEEDEDTEEGDDPNDVSDELPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J633</accession>
    <name>A0AA38J633_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1170742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000137">
        <property type="protein sequence ID" value="KAJ3710516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J633"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3710516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="211" mass="23605" checksum="8A3CCF4E48E8EE19" modified="2024-01-24" version="1">MTYWSQPVFQDSEIQNPCYDEAVHQPCLVCRDTPALASHSLSKLLQGELVRKGELVKLGIHSDVDLETLVLLGPDEVAELLDQASLTNFEKASLRNALKNIRPKFHVKQGATEADIREYIATVYTCQEHSNVRKLQAIPPKLLRLFNKLHIEHLIPAALLLGVTSDTHFEKIITFDDATVEGMICGQTAQIALSPLQKVVLQWALGKRGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6B2</accession>
    <name>A0AA38J6B2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1044222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000111">
        <property type="protein sequence ID" value="KAJ3712124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6B2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3712124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="109" mass="12455" checksum="AF8FF36BF1D135C7" modified="2024-01-24" version="1">MNRKGYKKDCKRKSGRIVTEVLKELEVTEFPKGLEMNGGLEMEWKNPMKWLNRNLMMAVMGNIMVGKWRLVGNISEMSREVFVGVNNDIQTYKVQLMDGQGKGDKGKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6F2</accession>
    <name>A0AA38J6F2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1003847</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6F2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041321268" evidence="11">
        <location>
            <begin position="25"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3722822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="497" mass="55831" checksum="5D7E85BC4BBF5E14" modified="2024-01-24" version="1">MSTFVTSLLVVCSILLIVFRPTRRQRIPYPPGPSSSPIIGNIFRVNLAQGAWKVFAQMKEQYGDIIFLHGLGTTVLVLNSQKAVNDLLEKNGSSYSHRPVFTVAGELMGLDQSLALIPYGKEWREHRKLANIALSAVSVQKYRAIQEELSALLNRDILEKPDDFFMHVRLAAARVVMSVTYGFSVHDSDDKYITHAEKTMEIVTTATVPGAFLCDLLPFMKHLPKWLPFMQTAVHGRNMVDTLVDRPFEQVKSELASGTAADSLAKDLFSIVENNPESEHRIKWILGTMYGAGGEATYATVLTFIMAMALYPEKQMKAQQEIDSVVGTERMPTIADLPNLPYVKAVIKETMRWNPAFPLGVARRSSEDDVYEGYFIPKGTIVMPNIWSSCIMFNCKSLYHPREFIPERFMDPLITTVDPLSYAFGFGRRYCPGRFLAENSVSIMISTMLAAFNISPSPNQKLEPDFGQNMISYPKPFNCKIAPRSENSAKLILQRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6L6</accession>
    <name>A0AA38J6L6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1133190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6L6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3727343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="751" mass="84751" checksum="9195F01548CEBA3F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J709</accession>
    <name>A0AA38J709_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1157170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000043">
        <property type="protein sequence ID" value="KAJ3726494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J709"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3726494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="112" mass="12906" checksum="5AE5E644B8C424E7" modified="2024-01-24" version="1">MPSLRSSGAPSNSPGPSRTIRTRRRLSPSHMMLGPLLNGDMMPPDEEKVNCSTWGLYFARGAAMSERKRFPSYRRRHSHTRFIEVEDDFGFNTYGDDIYKIKVIVDDRCYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J718</accession>
    <name>A0AA38J718_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_141192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000138">
        <property type="protein sequence ID" value="KAJ3710502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J718"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3710502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20488" checksum="A27303DF17122EAD" modified="2024-01-24" version="1">MAIYQQSKTLADKKIWELAKEHPDIDFTILLPPAVFGPLVPNFPLTDSQKSIGTNYNLSQIITTGTGAYPAYPLGHLADVRDVAHAHVAALSAPPSPGRDKRFIIFNTIFTWKKVADLIRRDRPELANRLPNQDLVPPRLSDAPLDTTFAAEVLGLKEYIPWEETVLAAIDVHVAWEKQNGLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J789</accession>
    <name>A0AA38J789_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CoA-dependent acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1086588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J789"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF2">
        <property type="entry name" value="ACYL-COA-DEPENDENT ACYLTRANSFERASE MAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3727362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56389" checksum="53F63AA538C5BBB0" modified="2024-01-24" version="1">MAVYNFCSTDGKTYKRNLHGFEALCNSYALHDFLLSFTGSAEVQLSDASGTPASHEKVISCLRAAWILLRYRVPGVALRTTYQPKDTSWTVFYDVPLGSEDIDTWVSQTLFWRETRPGCLVHELDEKWEFTHGEYPLRLMASPIEAGRYMLSLSGPHGMMDGRMSMILLNELIGSLHTQIYESATVDLKAIKWGEEIARLASTGAVLTGLDMNSSSEPAAQEKELVPFLPPFVENKDRTHDVTMRLVVFDDARTLALRQKCRENHTTVTIAVDAIFACAQAEAVLASAATIGGAHYTSTVEAYNKALHWFMPLSCKDQRPSWPTSSSIDHPEGTTLFGTDGFALQANIDIIRNALGFSVDAKSFNRCDNEFFWSSVIKEIAAAHEIPKKDLAGYVQREREKQEMCKTFHPSSMMVKLPISSSIGDFDHLGLFGRYLPSSTSPTKVHRVLFRARPLTPTITNIFYQYDGRLNCSLLAAAQWYSPPEMDEMETALRTWFDLVIGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7L1</accession>
    <name>A0AA38J7L1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1007339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000086">
        <property type="protein sequence ID" value="KAJ3715236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7L1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF4">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041281866" evidence="2">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3715236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="244" mass="26509" checksum="A669B9FA8D87AD46" modified="2024-01-24" version="1">MVSIHLLSKLILSSSTCVLAPEAMEGPYYINNEMIRNNLTEGQLGVPLTLDISVIDVTTCEPMEDVLVEIWAGMAIPGHGRPGGPEGPPSQPLSRNETFLRGGAPTSSDGVVELVTVYPGFYAGRTAHIHTMIHMNWERSDNGTFVSTSGTVLHIGQFFFQETWNDKVYATSPYIENNNKRTHNNEDGQMEDSEDADGNSAILDISAAGEDLTEGLVGFVTVVVNPRASYQITNNNYLNSTNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J892</accession>
    <name>A0AA38J892_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_999304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J892"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3731332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="289" mass="31492" checksum="A4F2BB8E485272EC" modified="2024-01-24" version="1">MKDLSSKWIKVSEPFPHILLIELARFWKAYGALFEDISEGTSDVRAVILSSAFPEIFSAGLDSTQFCTVLEAGEIAKATADADPESTDAARIALDFQKQIKPFQEAITAPERCLCPVIAAVHGMVVGLGVDIISACDIRYVASNTQFTIKEIDIGLAADMGTLAYLPKITGNMSFIREMAYTTQWFSASKAEQVGLVSKVVEGGKDEVVAAALELAKLIATKSPIAVTGTKRLLSHARDHSVAENLEYTKLWNSAMLQTQDMMETLTSTKAKRPGKFLTLNFKYGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8N0</accession>
    <name>A0AA38J8N0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1224747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8N0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3731542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="302" mass="32385" checksum="BD1E3279B338BD21" modified="2024-01-24" version="1">MFARRTAARVVAQPSLLAAPSNARNMATLREIELRLKSVRNIEKITKSMKMIASTKLAKAQRAMQAGKLYGAANAEVFETAKEGATGPQKLFIVVSSDKGLCGGIHSSVTKATRRAFSNTPDSPIAGASVEPDSSVMVIGDKSKAQLSRVLPNNFKLTFNQIGRDVPTFADAASVADLVVKSGVEYDSVVIIYNKFVSAISYEAAAIEIKGEKALKESEGFKKYEMEDDFTKDLAEFSLANALFAALTESHACEISARRNAMDNASKNAGDMIGSLTMQYNRGRQAAITNELVDIITGASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8Z6</accession>
    <name>A0AA38J8Z6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1000808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000037">
        <property type="protein sequence ID" value="KAJ3729176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8Z6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3729176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="315" mass="34404" checksum="3629322FEE4A3493" modified="2024-01-24" version="1">MGRLLYPDLSGRVAIVTGGNTGLGYITVRELARKGARVYMLSRTESRALTAIEKIKGELGPDLQPEILYINFDLLSLKSAKKAAEEFIQREGRLDVLVNNAGIMATPYELSPDGIEIQACNGTGHFALTVTLLPLLKETAAMPDSHVRIVNVTSNGYLAAHTTTPDFSSLEGLNQKTWSTWVRYGLSKLTNILFTNELQKRLAESGTTNIYCLSIHPGVVATELARGMYQGPQQSWPFLAPMWVIIGMLVMSPDQGALTQLYAATSPEVEEKDLKAALLFPVAQLKGKTSIAEDKDGKLGGDFWALCEALMRQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J975</accession>
    <name>A0AA38J975_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sphingomyelin phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_347230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J975"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="249"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="715" mass="78076" checksum="9393451F79DC39F6" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9R5</accession>
    <name>A0AA38J9R5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1073831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9R5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="189"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="422"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="867"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="815"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3732412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="933" mass="103083" checksum="64F2E8F2E2406811" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA56</accession>
    <name>A0AA38JA56_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">DFJ43DRAFT_1134746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="JANVFO010000087">
        <property type="protein sequence ID" value="KAJ3714913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA56"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="179"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3714913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="379" mass="41677" checksum="2F72E0F49909F5F8" modified="2024-01-24" version="1">MSAAEEVVYFEDIESSSRSDAASRVNSAVVTKTEGASSQANASKTTVTGVKRQLTLADMFSTPNTQPSSKRLKASASSSSLNSSPSRSNTTVFGIQKLNSIPFSMKAFQDSLDEEQTRLLRLECEFLGKSWLKVLKEEIKQPYFIALKRFLWNEGVREPEYLPRPLKVYPSPKDIYSWSETPLGKVKVVIIGQDPYPGPNQAHGLCFSVRMGVPIPPSLLNIYAEIKNEYPEFIPPKHGNLAAWASAGVLLLNSSLTVEARKANSHSDKGWERFTDKVIDVVDKWGGASIKVGLDGQASGIGRGVVFLAWGAFAEKRVARLNKNKHLILKSAHPSPKSAHRGFLGNGHFKAANDWLEEKYGPDGRVDWCKLEPGLASDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAV6</accession>
    <name>A0AA38JAV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1160388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000083">
        <property type="protein sequence ID" value="KAJ3715627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAV6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3715627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="276" mass="31599" checksum="7AFF281CD95E4B29" modified="2024-01-24" version="1">MSAVTPDKERRNKKDKKLDDLNLRPVDSEKIATGNNEMDVQKKRKKVKRAEKVQDKGSDKEEGSRSAALEQPDVDTVEQEDEVSSEKKKEKKRRKISELDAEGAPTKRKKKRKREDSENADTGDTLQAEKPKKKKSRNKTGFLDPAEEPSLSAQAQKALSYAFQQFRKPSKWKFQKARQNWIIRNWVTENIPDSQIPLVLKYLSNVQGNIRENLTKTCELIISTENSNPASPSVVTERNDDQDEDEMTQLTKQAIYPMKLIRAKAMLAALKDKTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JB58</accession>
    <name>A0AA38JB58_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1223687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JB58"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="62"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="508" mass="57109" checksum="9DD8E37377786667" modified="2024-01-24" version="1">MSTPSDNKHVRNDTAASTNSVLGGQALSKSPISRESSTDSQVSTSSATSSGIVPPLNAHPYRTLVLCFDGTGDQFDSDNSNIVQLFTILKKDDRDQQMVYYQAGIGTYTSPQIATPLMAKFSKTVDMAIGWYLDAHVMGGYEFLMQNYKANDRICIFGFSRGAYTARSLAGMIHKVGILPACNHQQVPFAYKMFTRDDEIGYAQSAAFKKAFSVDATIEFVGVWDTVNSVGLVPHRLPFTTSNTLVKTFRHALSLDERRAKFKANLWNPPSDYNHTEDVKDGGKHPHHHHRHLDLEHSRFYKDANQKTDIEEVWFAGCHCDIGGGSVSNTETVNLARVPLRWMIRECFRTNTGILFHSEGLRSLGLNPDSLWPEVKPRPDPLPVTSAHIRRIPRNPPPSEEIAESSIFKTEEELDLEDALSPIYDQLSLAPGWWALEFWPVKNKFHDGSGKFVSEIGCNLGRARRIPRQKQGVKIHRSVKMRMEAQYENGGKYVPKAKFDPKYVTWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBC3</accession>
    <name>A0AA38JBC3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1038842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000020">
        <property type="protein sequence ID" value="KAJ3733001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBC3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="321" mass="35161" checksum="0B7C6A0EAF8E1283" modified="2024-01-24" version="1">MNSAYIGQFQSDPFIQYGSTKLGACHQPHFVTPSHQDNPSNDEHVFNSKNPKNPNVILDSSQYSKASTRYTQKRTAAVDALNQVVLAQSPHFPRWHPRAQIHASFHPSRNILQSEYSSHPLAEPENAQISSQILPSHQTSTTALAPNIGNTRSGVIVAAPVPQKMIASSETVLHALHSVGNQSVAQDLSGLSFQGQNQPRQPKNNRLPAPSSKSQHDAKENPGHPLCVQDVHSPRSSSDIQERPTQSNFDEIVIADTDLNSAVERRDPLLSSSTSKNGKFNSEPLRSITPTTMIALTEPILMSWCFDDVAVQRLAKAAGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBU5</accession>
    <name>A0AA38JBU5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_995116</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBU5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="434"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="113"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="241"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="512"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3733511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="679" mass="77559" checksum="7E0E27910F3F0954" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JC65</accession>
    <name>A0AA38JC65_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1038294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JC65"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="263" mass="29680" checksum="51C766A31A2C0DB1" modified="2024-01-24" version="1">MKCSQSRAASPTPTAFSGISNHRTDSYKPTSKNAPPVPQIDYRSISKIHYDELHRYLTAYLARAPPNSRPAARQKLTRLTISQSHELSTDVYDELIRRKSEKEGKSVRAEFHPKRNQARQKLATLPTSKFEDLSSDVYFELARRYPEFKEDPAGRIPIGSNYDDYPASGFLFAWATRSRTPDLDNDLSRISSVEGSDVDTVLEPSLFHVSTAHNSPLSGHDKRERELASNANLTRMGFSPSESGRALPKRLRGFKSFMQSLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCD6</accession>
    <name>A0AA38JCD6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_140841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000136">
        <property type="protein sequence ID" value="KAJ3710601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCD6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="285"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3710601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="690" mass="75863" checksum="5FAC9C7C6369A03C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCT3</accession>
    <name>A0AA38JCT3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1042466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000061">
        <property type="protein sequence ID" value="KAJ3720712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCT3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3720712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="338" mass="37345" checksum="D70A3933A0C22A01" modified="2024-01-24" version="1">MFFSRKVITEDELVDLHGKVAIVTGGNTGIGYATIEFLARKGARVYMGSRNQGRAQKAIEEIEAKLQKSGNDNQASIHWLQLDLSDPRSVKEAATEFIAKEERLDILVNNASHSSFGPYKLNQDGLLDIMVVNHISHFVLTETLLPLLRHTATLEDSDVRIVNVSSTAHTHATTESFAARENLNKQFGDSVTGYLATYGHSKLANILHIKNLQTRLNAQTSPITCLAVHPGAVMTVGASGFLNSVPFFGWLLKVFFGPLFFTSWTQGAMTSAFAAAGKEVAETRKSKDEVERRKYEGGYLVPVANISEPSTYAKDERLQRELYETTMEVLTEMGIAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JD75</accession>
    <name>A0AA38JD75_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1061707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JD75"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001193">
        <property type="entry name" value="Rab family, other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="242" mass="26868" checksum="53F922640F6CEE2B" modified="2024-01-24" version="1">MAVNDWDDATELLETYDFLMKYIIIGEAGTGKSCLLHQFTHNSFKDHSQHTIGVEFSSRTIKLGEKRIKLQLWDTAGQERFRSVTRSYYRGAAGAILVYDITSRDSFARLSQWLADARALASPNLVAVLVGNKSDREEEREVEWAEASRWAAENDVHFLEASSLTGDNVEAPFMLAARSILLSIESGILDPEKAGSGVSYGDRALRRVNSSSRLSFGSLSGRPRKGTVKLKMKGWLPGSKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDU6</accession>
    <name>A0AA38JDU6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1008866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000118">
        <property type="protein sequence ID" value="KAJ3711460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDU6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="112" mass="12345" checksum="044832C363C6A1C9" modified="2024-01-24" version="1" fragment="single">SVFGALPAPDTSTSNFLTFFFVSMYPDILNSTLTKSDGHVKYMITTHATIPGYTLFKTLEDGSVVLIEWNYRGALVEIGGSVNKQHASMFLQLSGDRRCAFFVIDTDPQGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JDV6</accession>
    <name>A0AA38JDV6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DFJ43DRAFT_1157803</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JDV6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="18">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="19">
        <location>
            <begin position="139"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ3724274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="280" mass="32678" checksum="065DB55EF219C276" modified="2024-01-24" version="1">MAGSKFAYVKKFELPDTLLPSTFMVLRLDGHSFHRFSDQHGFVKPNDLRALQLMDHAAKSLMEEYKDIGLAFGESDEYSFLLRKSTALYNRRQAKIVSTLTSLFTSCFVFHWPKYFPDVPLQYPPSFDGRIVLYPSQREVRDYFAWRQADTHINNLYNTAFWALVQQGGKTTTEAHAILRGTVSKDKHEILFSRFEINYDKIDPRYRKGSVFVRVETTPEEPADELSTNTDTASARPVVSEESRRKEEKKKKKVATQIELLHCDIIRDEFWDKYAHLMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE01</accession>
    <name>A0AA38JE01_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1167639</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000116">
        <property type="protein sequence ID" value="KAJ3711662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="28"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1190"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1536"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="938"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1089"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1089"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3711662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1655" mass="182715" checksum="127DAF66ECBB36F7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE20</accession>
    <name>A0AA38JE20_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1160517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE20"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="260" mass="30032" checksum="92C0FF69BE17C28C" modified="2024-01-24" version="1">MVYSRSVLKAVIAVGAASSVLSVPCPLLELPIAVLYIGRTSGSLGVPAPGVPVTGANGAKTLSAREFNIIVEDEEEPHSHHRHHEHSVEKHIHHHHHHHHHHGEEEFEVEVKEHRGHRHPTLMARRSRWKLKRVAVITTILMAKRRSKLNSRKVTVIIITTHTVRRRLKLNSRKVVVTVTTTHHPHGEEEIEIELKEAHRHHHHHHHHHPHGEEEIEIELGEGRRHRHGEDEVKIEIEEVPHRHHHGHQCTTNMNLRSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE94</accession>
    <name>A0AA38JE94_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF hand associated-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1196183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE94"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3726420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="268" mass="30153" checksum="56F4E5F3DDA04999" modified="2024-01-24" version="1">MVSKEVSGRKRKRVTEFAQRAIADLRAQLDKELVAAKERHEKDLAAVRADFEHSAVTAKATFDRELANRDARITQLENSLNAVVRDKNSYSEQAQIRQAERKCFDAPLQLQELEGIREMVNQHADGGRGRLETTWTVLRKFGYAEDLRSTEAFLSPKFDIPPDCSVELSPPGYQFFTDIFETFDKDQDGALNPSELEEVFGTSPGNPWTSQGFPDTTLSDDTGSVTLQGWLAQWSMTTLLDHKTALAYLAYLGYPDEPRTSALQITRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEJ7</accession>
    <name>A0AA38JEJ7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_565211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEJ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3726376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="194" mass="21963" checksum="8CDB198F7367274C" modified="2024-01-24" version="1">MVLTNFPYVQTTQPETGRKNSADTPFSTSSYLFPTAGSTTYEPNQLNQTSYENFPSQYPLIQGEMRPDFMAVHPPQLPYPDHSTPRINEEYSAISPSLLTSSPPALKKERVASPKVKERADSKRKTSARFKCKYCESDFTAKHNLQYHENSHEGKKLYPCPHCESPFSVPRSRDRHSKSCKGMRSSDSPGAYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEK0</accession>
    <name>A0AA38JEK0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1040152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEK0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="312" mass="34839" checksum="62CE575D84FCF085" modified="2024-01-24" version="1">MIYTRQFRMDFSRDRTSSSKVLVRDSEGWYFAMNTEEVNAPGLFMGSSSRRGNDLVPKSEDSGQRCGSTTDMQSVTSGDPVSPPVSPSVSSPVSPPWESRTTTSENAARLSKEMDTPISLVVSKPSMSDIDSRLLDPLDGSHDTNCSQPESLGSFRRSGTKDLTRHKSVDDVRAYIILFHAITVSVSQLDSDGPKNPELNNDRFATFWNDVLWTMFLSKSFAMAAGNFALSVGIFALVRYQVPKQVQIRHKVARTYENLAFVDPSTIELRLVPDEFNGLAQISEMSDEIAYDDHIFERFVLGKMKNGWDMCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEN1</accession>
    <name>A0AA38JEN1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1029854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000048">
        <property type="protein sequence ID" value="KAJ3724963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEN1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3724963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="82398" checksum="8690D49796EF9AC2" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEN9</accession>
    <name>A0AA38JEN9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1002332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000044">
        <property type="protein sequence ID" value="KAJ3726436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEN9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="91"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3726436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="189" mass="20397" checksum="84E0472D96D2C90F" modified="2024-01-24" version="1">MSSLNSDSTFTSSYSHNVVGGSASTHIKKLLDDLVHTPSRHPQQKLFASTIMDSMILVDVSIGSMPEESSRLEGKVVLQLVLPTDMLNLANTVHGGCLAYFVDFCSSLALVALDVHQSNDYTLSVSQALNIVFHSPAAFGETIRIVNMSVSSGGRSATGRTEIWNENHKRIVASGTHIKMLPSSPKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEU2</accession>
    <name>A0AA38JEU2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1157038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEU2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3727199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="558" mass="62455" checksum="2BC1346F0BE1D091" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEV7</accession>
    <name>A0AA38JEV7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1195284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JEV7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3727244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="175" mass="19285" checksum="E5E873B8CB99C259" modified="2024-01-24" version="1" fragment="single">VVYYNFHALGLSLLFKPTDGYKPRTGLARSELMEDKLVLDSLDIYNIPASTSDSKGFQKKREETAFATYPMSPVILNLTHPEEEEGKNLPHSLQISKESTGKDFVQGLREPDRKGGGSGPFSGSIGIWCEWTKHGILVEFGGVEAIGPQAWERGKDAVWKVVTVFLPNINNSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JEZ1</accession>
    <name>A0AA38JEZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1038185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1152"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1347" mass="150470" checksum="B72ED7CB64BEDDEA" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGA3</accession>
    <name>A0AA38JGA3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1160375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000083">
        <property type="protein sequence ID" value="KAJ3715615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGA3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3715615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="210" mass="23008" checksum="E1313F54AAF63262" modified="2024-01-24" version="1">MINPSLSVSMRNLTRLMIHAGCLCFAEEAGSRLSRWRFCPAHASLHASSSLAGPTVSSNELLSQSISLSSLDSMDSMSALPIPSKSLKELNGVQLHVGYVFVQNTMVDKNTKNRDCACDLRLPPQPSTVPDRSVQTTAFTFNPFDNDVLVSGNIAPSVNSWPAPHSKAGRQPIVLGVKPKGSPVSRRYRKPHYMQKVTMWLTEIETLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGY7</accession>
    <name>A0AA38JGY7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1154975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGY7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="385" mass="43202" checksum="6DC757ED467FDBF7" modified="2024-01-24" version="1">MNTVRWEIFALLRDYASLVPARFIQIPSNISFAEMNRCLVELIALNPHFQLYAPSNQYQRSFWKTMVRQLEDLLNRSGEEDEEIDPRILDHYLSTLPTSGPTPGSSAPSLRGQICDRGLPLGEPPSKSFVTYFWKPKLNQVQEHSHQDMVNLTHYRSSTLEESRTTIEGGTTGLRTWFASHMLARYLIQNPSIVEGKCVLELGSGIGYLGIIVASLQQLSPKVSSSLWLTDVNEEVLSQCRRNVQLPCNISSTHKSVEFRVLDWEEVLHSNVKPLENLLQNQINPDVIIGADIVFDPALVPPLVAVIALVLQLGYKSGIQRSAIIALTVRKAETFQSFLDHAREEGLFFEDIPLPEANGFEIVDAVETGASADNVRVLRITLHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH82</accession>
    <name>A0AA38JH82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="7" type="ORF">DFJ43DRAFT_1084551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000038">
        <property type="protein sequence ID" value="KAJ3729057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JH82"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3729057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="426" mass="46796" checksum="476A4907D802F4AC" modified="2024-01-24" version="1">MHPFASYVLRNYYKATGWNEDNLFTNLTRSSDAILDFAVPKGLHLSISKSPNALFKTTYSMNAMPSLNGSVGYIFTSCDLNVKSSGDVRFKDMIERFRVYDQPRRPQGKGEEWLAGERVDTRDYLMYGRLYIPTGRLDALYSTRLSSNLQGILAAISDPPSPLSARANVSNLMLSLQHDVGKWCTEYTYSAEDSMWGIKALHNFGRIAGSGNAAESLQTPTQVGVKRIDEEDAVEGGLKGRLSAGAEIYFSAKEKSAGVSTGIRFSTIPDAKPPSAGGSTLVTNPPQPPTTITALFNPMLGHLSGAYSARVSTDLALSSRFDFNVYSYESEWTMGAEYWLRREDDLDGELLSSSVTPASKPSKKRIRGVVKARASTSNDVAILWEGRMRNMLISLGVIADFSSHGRVKPIRAMGMELAYFSSDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHB6</accession>
    <name>A0AA38JHB6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1153822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHB6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="131" mass="13235" checksum="6114D372BE20D74C" modified="2024-01-24" version="1">MKGVVESESVSGTTLFLWSTGAFSVARTEHVGATAIEYSHSDALPIGPAFVIDCDLVSSTAACPELMSFTGQSGTRATSSVTPFETFGVSVSATAARTSSSKNTAGPLKPFGSLAGACVVVVFLIVAVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHB8</accession>
    <name>A0AA38JHB8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_1083021</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000036">
        <property type="protein sequence ID" value="KAJ3729967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHB8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3729967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="401" mass="45024" checksum="9ACBE86901F57222" modified="2024-01-24" version="1">MLSLRASLAKTKHSFHHRHYRPSTSIWNASTKKPTSPDQPGNKHEPKPSTSTLETPEIINPDQASSSSSSTTSTSTSDPTTPASSSSPSSIEETQKKSLDELRETLLKWTNAWAYQFRRKADDLTGATKTRLSGLGAELNKVTGYEEIDALKRQVVEQEARIEITRQAARSAKIKHEEAVLRRSKSQREVNDLLHRKSGWTDEDVIRFTSLVREDHILDQEEARAKLAVEEAENAVENEFTELMRSILARYHEEQVWSDKIRSASTYGQLAVLGLNMFVFILAIVLVEPWKRKRLAQTFERKVEELNEKYKEMLGGNMQILQKQLEDQAIIIAALTAAVAKIDFQTQLPIEEVVQDEDEPVLNSTGIWTKAVKDRNFGEAVAMGALAASVLSAIGWIWLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHH1</accession>
    <name>A0AA38JHH1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1143178</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHH1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="31"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="350"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3736927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="415" mass="44347" checksum="D3B1FF3BC91662FD" modified="2024-01-24" version="1">MLSSLRKVGSLARAASAGQKRFLSIHEYQSVKLLNSYGIPTPKSIAASSPQEAFDVAKSFGHNRLVIKAQVLAGGRGKGKFDSGLQGGVHMVDSPEQAKEYAEKMLGSKLITKQTGAGGRICNAVMLAERRDPSHEYYVAVLNDRVTQGVVLVASAQGGMNIEEVAAKDPSAIITTPINFKTGLTKPEALDVAGKLGFKDSAADEAAEIFINLYRIFKDKDATQIEINPMAETADGKVLCMDAKFGFDDNAEFRQQDVFSLRDISQEEASEVEAQKANLNFIKLDGSIGCLVNGAGLAMATMDVLSLHGGNPANFLDVGGGATPDTVKKAFEILLADPKVKSIFINIFGGIMRCDYIAEGVIKATKELELKIPLVVRLKGTKENEAKQMIKDSGLKITAFDGLDEAAETAVQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JHT5</accession>
    <name>A0AA38JHT5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine hydrolase FSH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_414663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000030">
        <property type="protein sequence ID" value="KAJ3731488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JHT5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3731488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="257" mass="27959" checksum="0CD65B06683899FD" modified="2024-01-24" version="1">MSSPQKRVLCLHGYSQNANMFSKKLAALRQQLPEVELVFIDAPHVLQPVDLPAPSQMGYFSGFDSEPPPKDPQRGWWKTQNVQNIAAGLEVTLTLLRDVLKEQGVFNGVLGFSQGAVLAALLSGLLEKPAMYPSFLEDGKAVHPPFEFCISFAGYKPLDPLGAKLLTPNFKTPTLHVIGHNDIIVTPERAQSLIDASLNGRVEFHDGGHFVPSKTAWRKFLAEYIRNPSGDVPGPNGKAPATNGSTLVSEPVTPILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JI13</accession>
    <name>A0AA38JI13_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1074165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JI13"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="346" mass="37309" checksum="E47710C738580C02" modified="2024-01-24" version="1">MVSQSVKLGGSASNISVGKVAHGLMLLTAVSDEQAFEAIKAGVDALPSGAKMFLNTGEFYDKTWGIGNLLLLSRFFEKYPEYAEKTFLSVKGAMKPDGQGLIKPDSSMEYLQHSVDNCQKALGPNKKIDLYEPARIDPKVPFETIMSNLITLRDEGKFGHIGLSECKGSTLRKAYELYPGSVAAVEVEVSAWEYGQEQKDLIAAATELGVAVLAYSPLGHGLLTGTIKSSTDLPEGDFRARFDRFKEDNIKANLAIVEGLKAIAESRKPSITPGQLCIAWVASLGPTMIPLPGSSKATRTLENLEAGDIELTNKEIKAIEKVLAEHPVSGERYLGGAANAHLHLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JIG0</accession>
    <name>A0AA38JIG0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fragmin60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1146259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JIG0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="61"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="261"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="353" mass="39207" checksum="4FF4B89DB258B536" modified="2024-01-24" version="1">METHLTKPTKYDIEDSNIALLGSDLEKRVREHGGDKELAWDEAGTSTGLQIWRIEKFHVTPWPKAQEGKFYDGDSYIVLYTYKKTPESESFSYDLHFWLGEETSQDEAGTAAYKTVELDDHLHGIPVQYREVQGYESERFLSHFPLGFVCLKGGISTGLVEGDVFVLDKGTKVWQLNTKESAGKEKFRAAEFVRSLSDGRKGGCEVTVFDEGGHGAGIFLAEFGEDTTIHRESPQSTSEASDFNLYRLSDASGTPTFSAIESPITFSSLSSSDAFLLDNTLPSSSAAMYVWLGAQSSLTERRLAMQYAQKFLHDKFGDDVIGTKFKKAVAIPIVKMQEGQESEAFLTLFGGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ06</accession>
    <name>A0AA38JJ06_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1134119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ06"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3719630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="202" mass="22451" checksum="F11091D66D195344" modified="2024-01-24" version="1">MASMLRMYNVALQRRPMVTQCCTAAFLFGAGDIIAQQGVEGKGKNHDLARTARLTFYGGCLFGPIMTKWYQWLNTIKFSSPTRAVVYRVFLDQAVLTPAAVGFFFGSMSILEGKPKEAIPRIQAAYVPTIIRNWGVFVPTQVINFALVPHHLRFVVVSVVSLFWNTYLSVANARQTKASHLLEGPGSKTIAEFEAEVEKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JJ96</accession>
    <name>A0AA38JJ96_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_980873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JJ96"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="92" mass="10135" checksum="5B74FF0A1B2F090A" modified="2024-01-24" version="1" fragment="single">EPKTSPKPQPIGSITLIILLTTCTCCALFILWRRAEALRAVISHQLKTITRYEGQIRLSQDDGPPAHEFLEDDESTDDALELNAGDVGTLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKA7</accession>
    <name>A0AA38JKA7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1111111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKA7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="105170" checksum="6D2EB59738258136" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKB3</accession>
    <name>A0AA38JKB3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1071818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKB3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="133" mass="13480" checksum="278EC00319653659" modified="2024-01-24" version="1">MAGDNSRSPSSGPPPAQQRSRRRASRSTSVATDSGSRAPRNRRRGGGGQRQQQQQQGGGLPGVNEVANTATGAVGTAGDTVGGLTGGAADNKGDDDGGGGGDKPLRLRLDLNLDVAVELKARVHGDLTLSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKN3</accession>
    <name>A0AA38JKN3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1148843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKN3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="412" mass="44704" checksum="7FA9204C64A54BFA" modified="2024-01-24" version="1">MTISIVHDKAQQEQQQSELQSTPIPRDIVRKPLGNIENQPFPNPTASLCSDDLSSDGGPIRLTGLTPTLNHASSETPGWLSSSSLTTPLFSGSLRNGFGSDGPGGGNNFISSQTVSMDLNPNLITCLKDTTSLTPETREILDIYLQAPTLAEHLAVHFMQTLTTQSLLHQLIEEKNVHWEVSAALKKLISKYAKAYILSSMIKFYIKCAPEQTIVSALRASQARDLPGEDDVTASSTLKSAASCALVTAHAQVTDHIIATTAHAPKGQLPADQRDLGILQNVINNSSELTARDFWPQVDSEMANLLGVGHNPPKSQQAVLADFQLVYQIDTNKYGSPRVAPTNIGDPNYQWNRYVKNVNTLASNATISESGEVKGKQSGKRKRRQQDIGHGRKRASTDGHGSDADSDEDDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JKZ1</accession>
    <name>A0AA38JKZ1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_170761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3733917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JKZ1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041253890" evidence="2">
        <location>
            <begin position="30"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3733917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="438" mass="48969" checksum="EF98846E980CC25F" modified="2024-01-24" version="1">MCLRLSHLFRLYPLYLLLAAALLGVAVVASPVPRANTATAQRRSILLRIGHYDWEHRQWEQNCDGTTGGQCLKVLCIGDSRCFGYTPTNDLEWIAPKTVKRLQETKVKHVLYRTMKAYVYPLLFNRAQQSLYKSLSSVATLQAAIKERIRIEDDESCIRAILDLMVEKGIVIEYDGQQSLEENMKPVQIKTISKLRFGFYDWSKGSWVGKNVGIKPNFLCLPCSRMCLGFDEQGSTVREIQPQYYSISTDKRNTDPDRHPTLVYKFDNQELGDWSDPDHKDRTLVQFLQDTGDLNKAAGGDIKDPESYIRAVLRYLSLDSVGIIRGYDSKKPLSDLVNIPKRKKGGDGQDVGDEEIKRIKGGDDQDVRDGGDHTGVDNAGIAQETGRLTHEDGQVVRGGQEVGGGHRDRTANNAGTEVNNADTVHSASKSASIHNLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JLL8</accession>
    <name>A0AA38JLL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1154366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="JANVFO010000023">
        <property type="protein sequence ID" value="KAJ3732640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JLL8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3732640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="628" mass="70604" checksum="C14212B29132376E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JMJ7</accession>
    <name>A0AA38JMJ7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Succinate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1131457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000019">
        <property type="protein sequence ID" value="KAJ3733160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JMJ7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="6">
        <location>
            <begin position="37"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3733160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="292" mass="30930" checksum="99DB39662EF50F95" modified="2024-01-24" version="1">MMILRTSIASAKHVATRKFTQSASRKGPYDESIHNLLINQDTKVICQGFTGKAGTFHAREAIDYGTQMMGGVSPKKAGQVHLDLPVFGSVKEAMRETKANASVIYVPPVIAANAIVLEAIENEVGLIVCVAEGIPEADQIKIIHALRSQSKSRFLGPNCPGIINPLGCKIGIQPSHIYKPGNIGIVSRSGTLSYESAAQITGIVFIGEIGGYMEEEAADYIYNYNKSLPNPKPIVGFIAGSTAPSERRMGHAGALITGGKGAASHKIAALSRAGVIMVESPSRIGSEMSKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JNX9</accession>
    <name>A0AA38JNX9_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1062367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JNX9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03228">
        <property type="entry name" value="ABCC_MRP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF646">
        <property type="entry name" value="HAEMOLYSIN SECRETION ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="435"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="700" mass="78399" checksum="2E80D93635B64A1F" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JPC1</accession>
    <name>A0AA38JPC1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1052972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000006">
        <property type="protein sequence ID" value="KAJ3736017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JPC1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041386404" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9064" checksum="45CE02FFAA6334B8" modified="2024-01-24" version="1">MLQPGTTYYLILLTCLLILPSAALAPSVPQTACCKLFTSNWGLWRSLAMNQSEPGNSNWTRVASDLNSQPHRCSHIVVNTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQA0</accession>
    <name>A0AA38JQA0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_183555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JQA0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000554">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832:SF1">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3734080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="369" mass="42226" checksum="98B67212193A3F67" modified="2024-01-24" version="1">MTLPDWALQLGYEGLDRGLIPDFIVRLAIRALLRQRLREIDHGSLEANNAAKMAWIKNVKQRTCIADVPEKSNEQHYEVSTKFILSTLGPHAKYSACLFPTGNESLEEAEILMLESYCAKAQLQDGQDVLDLGCGWGSLSLYLAQKYPKSRITGLSNSSTQKTHIDATAKLRNLTNLNIITADINTYDFPTTSRFDRIISIEMFEHMKNYQILLRKVSTWLKPGINSDSESLLFIHIFCHRNTPYHFEDTEDQDGDQSNWMAQNFFSGGTMPSHDLLLYFQDDLTLVQSWYLSGTHYSKTLEAWLKLQDQNRETGLLELQADTKAKGQDPTEGVKAFYRFRVFYMASSELFNFNGGQEWGIGHYLFKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JQT2</accession>
    <name>A0AA38JQT2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1152054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="1555"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1662"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="955"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1368"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1392"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1439"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1461"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1507"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1668"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1686"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1731"/>
            <end position="1754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3734365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1754" mass="196244" checksum="BE8B6D8F98FA378E" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JRL3</accession>
    <name>A0AA38JRL3_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1066208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000015">
        <property type="protein sequence ID" value="KAJ3734106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JRL3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3734106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="238" mass="27242" checksum="E6416C4BA008BD3D" modified="2024-01-24" version="1">MKINIANPATGAQKLIDLDDEKRYRVFFDKKMAQEVPADSIGDEFAGYIFRITGGNDKQGFPMKQGVLLPHRTRLLLSDGHSCYRPRRTGERKRKSVRGCIVGPDIAVLSVVIVKQGEQEIPGLTDTVLPKRLGPKRATKIRRFFNLSKEDDVRKYVVRREVVSKKKEGAKPYTKAPKIQRLVTPMRLQRRRHLRSIKRRKIEHQKEQKGEYDALLAKRVAEKKAKVAAIKASHHKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JSS4</accession>
    <name>A0AA38JSS4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1036882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000009">
        <property type="protein sequence ID" value="KAJ3735370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JSS4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="191"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3735370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="355" mass="39561" checksum="841BAD211D4DDA50" modified="2024-01-24" version="1">MSAQAIPTTVQNPIALDLSSSYGALIIAAYISCAMWGINVIQTYIYYWNNPNDPWPTKLLLYYLDVVQGLLIDHTRIVDTAHKILVTKVPWFTLIQNWGRVSAILASPQEALHEAWVGSIIIVVVQLYYLRRLATFASRTRHVHTWYLWLVFIILAALAVLQVPYCVFSINKENIFIPINLDLKRVGLVAAAVVDVVIAVAMIMLLKDTDSIDGPRPRHSKRFSRTMSRLTVIIVNTGLVTAVVAIISLILDETASGTDFYTSIAQYPQCSIYFSAFLANLNARHFIRGPGEDMTVSNIEDIHFASVERQNDTEVGSIRSEGDSSGIETSHATNLEKYTRSDGTLNQSEGNLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JT45</accession>
    <name>A0AA38JT45_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1193483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JT45"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041490347" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="351" mass="37506" checksum="0DEDDFC3431BB341" modified="2024-01-24" version="1">MHFIQLYLVATSILFPFVECLTYHGADYSSLVNLENAGKTYKDSGTTEKFDAILHNHGTNLARIRVWTSTNNADYSLSYGLALAKRAVALGMELLIDLHYSDTWADPGHQAIPSGWPTTLSGLNTEIYTYTLNLVSAFSAQGTPIQFLQIGNEINNGILWPVGEISSAGYSPLSQLLHSAANGAHDADDSVKVVVHLANGWDESAVASFYEQIFIAGEFATTDFDVMGFSFYPFYDAGATYAALLASMNNIVSSYGKDVMVVETDWPSSGSCSGVTLSQSGIPLSAAGQETWVNGIKNVLSEVSGGHGIGIVYWEPGWIGNDALGSGCSNNLVVDDSGNTLASISLFSADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JTU0</accession>
    <name>A0AA38JTU0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1186514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JTU0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="106"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3737173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="602" mass="65750" checksum="1DE4F01AB578FB71" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JVJ6</accession>
    <name>A0AA38JVJ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1038184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000016">
        <property type="protein sequence ID" value="KAJ3733673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JVJ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="394" mass="45170" checksum="EF37E035104C2ECE" modified="2024-01-24" version="1">MEHDSCKDDLTHAGEQLQEAKIQLEELQNELSCKIPSFALDITFSLEKQNLELKELREKETRAKEEVQVLTSTIATFKAERDDTMQKLNNEQYTNMMNEANHADVLDDLEDSWQQQLEKCEKEYLAQEAALKAQLESSSSNLADTQNERDKFKEELRQLKSVVDKEVLSKANLIWSHKSKLKTIDQSLAEAKSEIDCLTNKEKALAIEHNNKENELNAALVVEQQSVQDLTTKLSETSDLKEEKNQLKSKMQELTQELASVRAEMKLFKTGTATDTKERIDTESKLRGKVQELTRNQMKFEREKKQQEHNMQNLTQNLTSSQSDVEKLNLKLTALEKEKNKKEAQLTAEVQALTTQMLEKAAILSSLEKEKHEREARVRELVGELGSVDMLTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JW31</accession>
    <name>A0AA38JW31_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_512157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JW31"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041451984" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3736626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40703" checksum="B57F12CE367D3B46" modified="2024-01-24" version="1">MNFFLLLWLPIFLTLRAETARALKIHIEAAKHITAGLNTTILWTRNETDPTAFAVATLRNGGSDLMIVYTAKSETKGNLSFVFNKSGKFQLVALEHKDQSNATKVDMHKANSTLFKSKQFKVEELSSSPTTSPTPSATSTASPHSQTPVILAVCLGAVLFAVIALFLVYYVLHRRRRRSFPKVLDDRYAFSHPPQSTHSRSWLFRNVWDNPTAQTSPISLQNQGNNVAESSWPDTLNFYHTPRSPPKAFAKNTSSSRVAGGTEVSNHTETSLSSMHFSPKTERQMEIEERIEELRAKLALLQRSIRVPGGRQDSRTLINMTHNMRIGKWRNQIEKLQEHMSSDWALGRTDVIPKGLYGPESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JW65</accession>
    <name>A0AA38JW65_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_525037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000004">
        <property type="protein sequence ID" value="KAJ3736746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JW65"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3736746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="202" mass="22549" checksum="C38777F9FD48AB33" modified="2024-01-24" version="1">MDHWRRESFFCEWYIHHLHSYLTTFGYISRSIGTSRSTVFIISTTSFTPSSTPTETPNRSESSTSSNVYPIASSQVIPVTAVSGTKSSHLGAIIGGIVGGVALAFIIALVALLRWHRRKQGSLARQMAFDKEMMVRPWPDFSLRRVARSWRSQSTKLRRYGINSERTSEYRGDSSSSSTMSISEGYLSEGSIEKQDGSEAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JW82</accession>
    <name>A0AA38JW82_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DFJ43DRAFT_1128682</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JW82"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="225"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ3737500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="380" mass="41076" checksum="30A1774C462A4EA9" modified="2024-01-24" version="1">MDSLLTEEEKAIRESANAYCQEKLMPRVLRGWRTEEFDPAVIPEMGALGLLGPTIQGYGCAGVSNVAYGLIAREIERVDSGYRSTASVQSSLVMHPLHEFGSEAQKEKYLPRLARGEIVGAFGLTEPNHGSDPASMETTAEEVDGGFIINGSKTWISNAPVADVHVIWARCKWDNKVRGFILEKGTRGLSAPPIKNKISLRVSLTGSIFMDNVRVPQDSLLPGTKGLGSAFSCLNSARYGISWGVMGALEDCVARARSYALERVQFKRPIASFQLIQKKLAEAQSEVAIGLLASLQVGRLKDQGLLAPEMVSLVKKNNCGKALQHARSVLDILGGNAASDEYHIARHASNLQITNTYEGLSDVHALILGKAITGIQAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JWY1</accession>
    <name>A0AA38JWY1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DFJ43DRAFT_988775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JWY1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="90"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ3737061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="424" mass="47698" checksum="032C1BB5EAEAFF53" modified="2024-01-24" version="1">MSISTAGPSTPSRKRSRWQNSDDDNEEDQQLIINPVKRRTKPKPSKEPPSSSATVALPNIKIPGYPTHSIYVPPRTHHPPITPSRSVYCYERLNQIEEGTYGVVFRARDKQTGDIVALKKLKLDEEKNGFPITSLREINALMACRHDNVVGIREVVVGDTLTQVFIVMDFIEHDLKSLLTLMPSPFLQSEIKTLMLQLLSAIKHCHTNWILHRDLKTSNLLMNNRGTIKVADFGLARRYGDPIGVGGMTQLVVTLWYRAPEILLGAEKYSTAVDMWSVGCIFAELLLKEPLFQAKNEIELISMIFKLLGPPTNNSWPGYSSLPLAKTITLPSPHLHQFRQKFQYMTTAGIDLLMSLLTYDPDQRISAEEALDHPYFTESPLPKHPDLFGSFPSAAAGEKKRKVFDSPSAPTRAADYKLLTDFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JYP4</accession>
    <name>A0AA38JYP4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1059008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JYP4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3735248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="250" mass="27632" checksum="E7BEBAA7C34E80C6" modified="2024-01-24" version="1">MCAHWYPEGYVLPTSTAYPPGPYHPAYTEKLTSHSRAPKPWYDSQLPHSSQEPKLSSTRTSRTSSSAQTQSTSSSASPTGHIIAGISDPGLVSGVDYFKIGDTVRVRRLTSANTYTDWAYGQVVRPHLKQYRTTEPERVYYVSYVDPRNGERKENEFSCHRKEIATLYERGLGSQPSLVFALVPLGSSSKWVPANIIHMSASGVDVRAVSKHLQHGYPTHFRGVQVLVPYNASVVRSLKAAGHEVVGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1G1</accession>
    <name>A0AA38K1G1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_390122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3736973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1G1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3736973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="227" mass="25528" checksum="5210A424F6D489A7" modified="2024-01-24" version="1">MLKRQRAPSPPPFSSSNIPLIADSTPTENARYTKRRRVHPPVLDGRMRGWGTAQDTLHETFDAGEDDGEEDIIEDDEFWPGPVPSDGANPNSPYKSTNGFLHELHTLQRHRVLSSTNASIQTPNSNYFAYDSSSPQPHAYDRHLHPPGKGPFSPTNIPASVNTVNQHETHALALAANYEKQYDSNLARGHYEEGNRYCIPSPRDFAHHLHACILDYWAQSCYLDVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38K1U1</accession>
    <name>A0AA38K1U1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_987896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000002">
        <property type="protein sequence ID" value="KAJ3737213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38K1U1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="506" mass="57552" checksum="D57D51A946F645D4" modified="2024-01-24" version="1">MFPIPSAATISTLVKAQKPWPPSPEENRLQEAESSEARVRLPRITGGLPRPNEDLFAFIKRRDERRLRVISSETTLEHQSRLQREENAGRDRPPGRKGARVYYWDLVEGIRVRTAVGRSNYEDIWERYGSHQRHYDSVADEWDICTDLDPHDGPDYDDLDSDDDYDAYFMSANSEMNEEGDHNVGAASSDAFLVRLHRSNDLPPASIQFLEPIVDTAYHRFGFLKQPMQDGRELIISPKIWMKTLGLLGHGRPPLPQGPDDQTKLQLCQFITDLLASSDLQHAPRLCDLAATDIHRRPLIPFEVDAVSSYNGLWFIIQAREARDNEAFSIGLRSAATVMEIARRRWGPRTEDILKCLINEGMPFNTLKASHSPRERKVMPRRRHAILGFHPAGFSPTLQDYHAYEVLRDDFLRSARGRAALLAGGIVARLARDAVNEQDVYDGPTENALQEGEHVLCVWEEGKHFALWDDNLTEEEIDLICGTYEVATGMSHPFTYHDTPNSKCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRB7</accession>
    <name>A0AA38MRB7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1043001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRB7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="156" mass="17139" checksum="968DC035B2912A26" modified="2024-01-24" version="1">MLKAGQKQHLVGPDIKVILSLNKEARTYPFSSVHHILDYKCPSTPTYEGFEDEIFQTPTPWAEFPTCLCSKHSRVIFWSYCSSYSSCSLCPNVLLTGSEAVPVGSDGPQTSKTMESDGLSIGNLGSDSVGRKGTDLEDFEEESESEIQDNDMATET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MRZ9</accession>
    <name>A0AA38MRZ9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1042163</name>
        <name evidence="9" type="ORF">DFJ43DRAFT_669144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Self-assembles to form functional amyloid fibrils called rodlets. Self-assembly into fibrillar rodlets occurs spontaneously at hydrophobic:hydrophilic interfaces and the rodlets further associate laterally to form amphipathic monolayers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000056">
        <property type="protein sequence ID" value="KAJ3722138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MRZ9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041513907" description="Hydrophobin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3722137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3722138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="134" mass="13281" checksum="A6C4223A54767785" modified="2024-01-24" version="1">MFSRISTVVFYALFAFAILAAATPGGKPTTTTPPITTTVTVTAPATTTTVTASQCTTGDLQCCDSTTTAGSAAGAAILGLLGVVIQDVDVLLGLTCSPITVIGVGSSSCSSNVVCCEDNSWGSLISIGCVPVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS71</accession>
    <name>A0AA38MS71_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1158005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000051">
        <property type="protein sequence ID" value="KAJ3724155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS71"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3724155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="377" mass="42023" checksum="ED0F4F8568D1D0A3" modified="2024-01-24" version="1">MHAKNKAFIALQLLGAFFFFLVAITAAFSSRVKRYATWYSFCASWVISGISYSLMLVVEAYAGAQGLHRWHPNVEVGSVEWKAEKVCMTQAAFIYASPALTGFTSLAMCFHVLLYVRVALEVPMGRVKAMTTTVLVVVPYVIWVIMFAVLFQLSQAQPNTVELDRSGYYCHLALPEPVAVCSGIAIFASISVAIVETLMARAVHKYRDALPRTTHSITFTLRVLLFGFVDLFALIIGLLLLIPASRNLGVNFLLSLIPMLGIFIFGSQTDILHVWMFWKRPFPESMASQPIPTRHCSDDADSFTLRQPNARSKRGRRRSTSQSKLGPFSVSSDLSTTFRTANPRALSISMLDDAVDTTYEVDERINASNTSRLSKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MS76</accession>
    <name>A0AA38MS76_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pheromone receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1003210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000050">
        <property type="protein sequence ID" value="KAJ3724230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MS76"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3724230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="311" mass="35548" checksum="63A6006B8EE8191A" modified="2024-01-24" version="1" fragment="single">MPASDPTFPLFSILAFLGFILCAIPLSWHLQAWNSGTCAFMIWTGLACLITGINSIIWADNALNIAPVWCDITSQLILGASIGIPASTLCISRRLYRITSTQTVSITRDDKLRAIYTDISIALGIPILFLILHIVVQGHRFDILEEYGCTSVTYNTLPAYFLYYIWPIAIGLVSLIYSSLILRTFYMRRIQFNQLLSSNGMINPSRYFRLMLLALIDIMCTLPIGIYTIYISLKGLPLAPWISWDDTHYDFGFVQLVPAVIWRSDFRTYTSVQITRWLPVACALIFFALFGFAEEAMKNYRRVFWFFAKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MSI5</accession>
    <name>A0AA38MSI5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1122612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MSI5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="9">
        <location>
            <begin position="188"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3727260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="234" mass="26637" checksum="62631393EC2ECEA7" modified="2024-01-24" version="1">MDLVISEPSPSKIQVLPHNQYQTLDSLTPSTVSASPLDQFHIWFKQVVEDGVVHEPEAISLSTATPSGVPSARMVLFKQLDERGFIFYTNYTSRKSKEMEANPYAAMVFYWREVHRSVRVIGKVEKVSRKESEAYFKTRPKGSQLGAWASRQSQVVKEGEVRERLKKLEERFGSAGDGDANIPTPDFWGGWRIIPTEVEFWSGKPSRLHDRVCYRLEEGSTAEDPKWTIECLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MTY5</accession>
    <name>A0AA38MTY5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_306581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MTY5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3732389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="772" mass="86369" checksum="20CA23C44CF5A599" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MV28</accession>
    <name>A0AA38MV28_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1103104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000088">
        <property type="protein sequence ID" value="KAJ3714870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MV28"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3714870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="528" mass="57651" checksum="7FBB7AD95413DF45" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVF4</accession>
    <name>A0AA38MVF4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DFJ43DRAFT_993339</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">ET3784</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000013">
        <property type="protein sequence ID" value="KAJ3734399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="19">
        <location>
            <begin position="398"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="18">
        <location>
            <begin position="739"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="18">
        <location>
            <begin position="772"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="18">
        <location>
            <begin position="840"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="18">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="18">
        <location>
            <begin position="905"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="20">
        <location>
            <begin position="1192"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ3734399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1489" mass="166396" checksum="AAA84825116EADA1" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVN4</accession>
    <name>A0AA38MVN4_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_95522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVN4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3734684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="221" mass="24077" checksum="E9B766696BCADEA0" modified="2024-01-24" version="1">MTSISTSIQRLLGRKPSSQLIDDYLNELSSAGKPSALTPEIKSYSDVVYYNFHALGLSLLFKPTDGYKPRTGLLRSELMEDKLVLDSLDIYNIPASRSDSKGSQKKREEIAFATYPMSPVILNLTDPEGEEGKNIPHSLQISKESTGKDFVQGLGEPDRKGGGSGPSSGSIGIWCEWTKHGILVEFGGVEAIGPQAWERGKDAVWKVVTVFLPNIENSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVT3</accession>
    <name>A0AA38MVT3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1-Cys peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1007296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVT3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3715310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="238" mass="26669" checksum="991A221B17054C2E" modified="2024-01-24" version="1">MSSVTAPPPDPNRPSLRLGSVAPDFSAETTLGPIKSFHEWLGNSWGILFSHPGDFTPVCTTELGEVARRAKAGDWEKRNIKVIGISANGLEEHYKWVKDINEYGTKSISETDVQYPIIADADRHISYLYDMLDYQDATNIDTKAGLPFTIRSVYVIDSAKKIRLKLDYPAVAGRNFDEIIRAVDAIQLGDKYKVATPVNWRPGEDVIVHASVQGEEAKRLFPEHTVHYPYLRTTPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MVW5</accession>
    <name>A0AA38MVW5_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_69780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MVW5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3735059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="683" mass="76637" checksum="F177160B940A4F24" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MWN4</accession>
    <name>A0AA38MWN4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1006550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000075">
        <property type="protein sequence ID" value="KAJ3717256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MWN4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3717256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14396" checksum="08E7E79C28698586" modified="2024-01-24" version="1" fragment="single">MVRHAESDEKKKQRESEAKADLQKRAVEAYQEELAQRKLGLPNVGAKAICDRFTALYRMETGKTIRLNHATIINHSTRKLTRAESNASKAWLTVGETDAVIAYIIEVANQGFPLSHRQLKEHVDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXE8</accession>
    <name>A0AA38MXE8_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1096794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXE8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3719669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="164" mass="17898" checksum="DAE50C50734F53E9" modified="2024-01-24" version="1">MFSAFRRAVREVTIFHHPSSPPSQKALEMLKSAVSGPYPPTKATTPPLDFRLEVVEAPPTPDQLTTIMSYVSPERTASTASIFLSSHPSTPSGSEAPQTTSAIHDIGAKNPNVMKWPIVVDWTAGKASIGDIEGVKSMLETLRKQRDGEIPKDEKIDQPKGWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXS7</accession>
    <name>A0AA38MXS7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper fist DNA binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1090482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000049">
        <property type="protein sequence ID" value="KAJ3724294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXS7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3724294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="397" mass="42574" checksum="FD3CF06E7C5C0A93" modified="2024-01-24" version="1">MVFVNSKKFACEACIKGHRSSSCSHTDRPLFEVKKKGRPVSQCERCRELRQSKKVHSKCDCNSKEQKSVKPRTAPGQKPPRFVPIAPALPNGIKDVIRASSSSSSSLRQRVDTLLNPCCCKNPAWKCKCREPNNTSYSTGLITLLQAAQLGCPIESSTIPLNSDTLPTHSHKRIKHTHDISGPELPPFLFDDSSPPPADTIPDFGIMPPIEEIASLAGSGCTCGVECTCPGCVEHRGAEHADTEQQNHTRDPCGTCVDNHQGIGLPDSSSSLDPRYTSSRMINQFFARAASIPPPPANRKMGIGITLDPGNVMVYPTAAMETKERGVPFGLITIPKLECCGGKCGCPTGDCSCGKSCDGCCTDHLHSTFNDISAAGQAESPTFRVISAAAKSCCSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXV4</accession>
    <name>A0AA38MXV4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1149496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000003">
        <property type="protein sequence ID" value="KAJ3737024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXV4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3737024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="89950" checksum="8173FEDFA49C9877" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MXY6</accession>
    <name>A0AA38MXY6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1087125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000042">
        <property type="protein sequence ID" value="KAJ3727216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MXY6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041345911" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11075" checksum="73C67DB05DDE4412" modified="2024-01-24" version="1">MPDQVIILVWILLPQRSSSEAATRGRTLVLTWCDGSIMLRYILKILVKLPQIGHSSEVVGKTSEVQFLNVFRLSHSKSVFTLALENSRLVGIKFEIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MYK0</accession>
    <name>A0AA38MYK0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1045192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MYK0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="96"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="357" mass="38623" checksum="D67F8484CD7EF31A" modified="2024-01-24" version="1">MSKSVKLKVTRHMIGITIKTGPLKKLPNHLAITEGSDVIGIWIPPIPELIKDELEIWANISRVTSIRIPGYWQYKKRSTVDVAAFNPVPGEKIVYSLHGGAYVTFSAHRSDPTAAIGRSLLHHVDSVHGVFSCEYRLSSGEGMEAQNSFPTALIDALAGYVYLVRTVKVDPSDIIVEGDSAGGNLALALTKYLVDHQDSDLPAPPGALILLSAWTDLSPQVASPNSSWLNNANTDYITMESLTSSLNSFLGPQGLDAASTNPIISPGSRDPAMKIDFRGFPRTFIAAGGAEVFYDMICSLKEKMISDLDEGDGVHPGDGKVRWHCSPDASHDWVAFSHDDSERLDTLKAIAAWVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ11</accession>
    <name>A0AA38MZ11_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_546831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ11"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041224119" evidence="3">
        <location>
            <begin position="23"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3727368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="591" mass="63199" checksum="2CD105DD7B215198" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ15</accession>
    <name>A0AA38MZ15_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_998883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ15"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3731580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="60449" checksum="3110AC2AEB2A4A58" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZ26</accession>
    <name>A0AA38MZ26_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1225642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000040">
        <property type="protein sequence ID" value="KAJ3728047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZ26"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041406667" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3728047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32070" checksum="1BADCABDC013A85D" modified="2024-01-24" version="1">MQKAYRVFILILALTMTTTQAAPLDGRGCALDPEHYQHEHSSRAPNSNTLGPRQPSHMPLVISTTSVLVSRTWGVTLQSLLDNGAIKPFEDVLVNNDKKVFDPEINDIEFGEEITEGVNNHGIWEVVSYRGQPRDDLIAKFFREAKSEEYGEVKALKMMNLLVESGKTMDPQPLRKSSLLPVIIMKKKEGITCRQFIENSCSKDSSHSQAQGPLLDWKQTKKMMCKQAAKDAVKFLVFHDDNSDQNGLVTIDEGSVKVELVDYGDAYMVIDKSIPEETFYKACIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZB1</accession>
    <name>A0AA38MZB1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1132374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000029">
        <property type="protein sequence ID" value="KAJ3731670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZB1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="342" mass="36337" checksum="FECFDDC4F6D6CFE9" modified="2024-01-24" version="1">MSEQKALLLEKAKGSFVVSTVPILKPGPGQLSIKVVAAALNPVDWKIQAWDIIIKEYPVILGTDIAGDVEEVGEGVEGFSKGDKVFGQGYFVNEMGGFQQYALIPAEIVGKIPPNIDYAQASTIPLGFNTAAIGLLHAQPEGAGLNPTFDPNVNFSGQPALVVGGSTSVGQFAIQLFKLLGYSTVITYASARHADYLKSLGATHVIDRGEVPVGSLAETVKKIANTPIKIAYNAVGDNDTRAACVDAIVEGGQVVDVNPEAKDPGNGKKVFSVFGTSHYPPHREFGRILWKTLPKLVQEERIVPNRVEKLPNGLAGIDEGLQKLKANKVSGVKLVAFPQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38MZF2</accession>
    <name>A0AA38MZF2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Symplekin tight junction protein C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_368738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38MZF2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="104"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="978"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="837"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3731835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1226" mass="134578" checksum="B490C79616DD8ECB" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N079</accession>
    <name>A0AA38N079_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1073972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N079"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="356" mass="38988" checksum="C1900A14F3CF5881" modified="2024-01-24" version="1">MTIQSPSFISDLEHILPVETDGPLNPSIRGITSDAYLIQSLAISSSSDHIAIESTNNNLEIHPDAAGLPGHCQPGLGVAFISYNSSSGVAPPDDNISSAFDRLRLDEYAARVSTSRPSLSLQLPTSPWHSNPSSPSQIYSHQGSPYSSCSDFSPNLLMPTHHQGPDTSRDNERWPIGSGRGQSLSDSAFHTPWRSRSSSVTSEEYHSHSGWGRGSSVVSDASEFSFHIDPRLLSSPRSTTQSHLTESSSDNGLPVSVSPHECSSSSHEPNSGPHTHVATRKIRIASERRRKRGARFFCEVPGCNGSFTAKHNLINHTNSHEGVRKFKCNLCEKRFITNAVLKRHIRKCRMRLSSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N123</accession>
    <name>A0AA38N123_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH:flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1074132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N123"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3732482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="403" mass="44792" checksum="5DA34A638AC3BA39" modified="2024-01-24" version="1">MKFTNDAVTGVSGYFPQNNPEIGTPLEKTDSVPLLFTPITIGNVTFKNRIFAAPMCQYSSDNGHATDWHLVHIGSIAARGVGAICMEATSVVPEGRISPEDAGLWTDSQMEPLKRIVNFAHAQGTKMGVQLTHAGRKASTYAPWVQHKAGSRSTASQEENGWPDEVFGPSPIPWSENYVEPKELTKDQLIEIEDAFIASIARCYKIGFDFIEIHGAHGYLLSSFVSPLSNVRSDEFGGQLCENRLRWPLRLIERCRAAWTKPLFVRISATDWAEGPEQENGVWKQFGIEQSRVYASEMYKLGVDLVHVSSGGNWSNQKITVGAGYHVPFAEYIKQAHPTQLVGVVGLIKDPKLAESYLQEGKADVIFLARALMRNPHWPLEAAEQLGVRVKAANQYERAFYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N1F2</accession>
    <name>A0AA38N1F2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1039328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N1F2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="461" mass="50470" checksum="A2DF0A8FD9B1D9A8" modified="2024-01-24" version="1">MCEIIHLRLKSHIEEIQGSPYPHHSRASPIRVSEVLTGRGCPAARAGPGPGEFLGIWYKSDGKMFQYICLKQGASQNLELSSNRIKELEAQLKPLQERLNGDWVHSIMTKSCFEQTKSNLADQQKKVIDLQKQLADSKEADLLKQVAALKKDAETCSQDNQRLKDQCEDIKKLKETNHKLEQTNAEYRADIDKMASTPGTIDSTVPQIFGATRRNARKILSKVDVEAAISGANRKYMLRGPIESNNPCYAADTESDDPSQFSYMLGQKPKLKSPYLVKTKRANAGAGLTNDKGKQNLASTVPPNPTMDVMSGLNDTPTNTTPGTNGKGKQKESTAPVTPIIDMTSAVNDTTTNMMPGSTNPKGKQKASTSSGEEDIHSDDDIESKKLVRMQLREMLNVTKNNNGTRRPGIEQVLKSCLEDFLNGAAESGPGLRCTYLNTSGQSIDELMASTSGSHPRTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3P2</accession>
    <name>A0AA38N3P2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1060675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000011">
        <property type="protein sequence ID" value="KAJ3735107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3P2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF33">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="25858" checksum="53123AD3023322F8" modified="2024-01-24" version="1">MNHARPALLPHTGGCISVPFLGRSRDFPILPMASLQGDVAFITGAASGFGLALTKELVSKGAKVIMIDINDCEREVSELNSKAGKIVAIAQRADTTSWEQQYAAYEAGKKIFGRIDYFFANAGIAEHPWLPNFNPSTARDRSIIKPDIVTLSINLIGQLYTAALALQVFERQTQNRHGFKGKLLMTASVYGFFPSAIMAMYASSKAAIFNYTRSTALIYAGKGITVNAIAPSMARKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N3T1</accession>
    <name>A0AA38N3T1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_102101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000012">
        <property type="protein sequence ID" value="KAJ3734778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N3T1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3734778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="143" mass="15798" checksum="C2E4CE02380F8C7D" modified="2024-01-24" version="1">MASTKAVQTFGKKKTATAVAHAKEGRGLIRINGSPINLVQPEILRLKVYEPVLVAGEENFAPMDIRVRVKGGGHTSQVYAIRQAIAKALVAYHAKFSDAYSAMELKKKLVAYDRTLLIADPRRMEPKKFGGSGARARRQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38N554</accession>
    <name>A0AA38N554_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1148855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000001">
        <property type="protein sequence ID" value="KAJ3737716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38N554"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041220938" evidence="2">
        <location>
            <begin position="19"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3737716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="409" mass="41563" checksum="D6851BEA9FD166FA" modified="2024-01-24" version="1">MRFSTTLLLTAVPLAAYAAPLRMTKRQVAAIDVTVLQFANTLEQLESQFYAAGLSKFQDSDFEAAGFGVSSVAIQQITNIQSDEATHASVLEEELTALGQNPNSTCSFNFDSALTDVATMAATARVVENLGVMAYLGAASLLTDPQLLEAAGSILTVEARHQTILNVLSGSGTAIPSAFDLALTPSEVLAVASPFFSGSCDLGIPANPTLTVTNTGTISQGTSLTFSSTAINSSVDTSTLFCQMMIGGNPFSISLPYNQCVVPNTVNGPVAIYVTSDDNPLQSNVVNRASANNILAGPTVAFIDAQPETLGQMVRSSGTGTAAASSSTQTISPDVAASIISAQGTSSASGAAATDASAASATDSASAAASTSNSVNDSSDPSAPFRDDFTGLAPGGVINVVGWSNIPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2G4</accession>
    <name>A0AA38J2G4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1168992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="JANVFO010000120">
        <property type="protein sequence ID" value="KAJ3711431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2G4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="2-isopropylmalate synthase-like post-catalytic" evidence="7">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3711431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="545" mass="60971" checksum="4638A66060EC78D0" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2N1</accession>
    <name>A0AA38J2N1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DFJ43DRAFT_1104202</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2N1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="47"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="233"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ3714315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="461" mass="52913" checksum="D0C8BFC0A885BB74" modified="2024-01-24" version="1">MNFLHSGLAAIQRHLAFVSVDPVNWKFYVQVFSWSVTIFESYLLLRQYPLYSKTTPPEALAPHIGKEDFDKSQKYGKDKAQFALFSKLFSQCVDSAMLQYGFYAWCWEAAGTILGKLGYGTDHEILQSIVFSFTMYLLSSLPTLPLSVYSTFVLEEKHGFNKITPGLFVADLVKSWLIAFVLGAPFLAAFLYIFKWAGDRFVPWLMGFMISFQLLMVILYPTVIQPLFNKLTPLSNGELRTRVESLAGKLHFPLKHLYEIDGSKRSSHSNAYFFGLPWSKHIVIFDTLMQQSKPEEVEAVLAHELGHWYYLHPTKMMAISQIHIFTILALFPAFLHAPPLLRSFDFPKHVAAQPPTIVAFLLFQMILTPLEAFISIGMNAVSRHFEWEADRFACELQDKLKEESMTDMGDRLGRALITLHVKNLSTVWVDWLYSAYHHSHPTLTERLKGLESFRAKRAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2U1</accession>
    <name>A0AA38J2U1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_858721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000089">
        <property type="protein sequence ID" value="KAJ3714647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2U1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041244296" evidence="2">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3714647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="188" mass="20201" checksum="B7C8A68D4767FAA7" modified="2024-01-24" version="1">MRFTILFLSIPVAFTLVNASYPSEASFGGDELLTRATEVDSDTGEVDPDVLSKFPKPPRNAPYVIVSPPSVPPLSGPPPNRWLPSLPPPPPIPPRNPLRVTKTALTSSVNTKTGHSKHSHAARTLEKGLSQGSAIADTVTSDTTVTSAITGTDSNPSPQGNRGESANKKRGDRSYDRRRIVHWGEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J2Z9</accession>
    <name>A0AA38J2Z9_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DFJ43DRAFT_1102301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ET3784</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JANVFO010000085">
        <property type="protein sequence ID" value="KAJ3715284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J2Z9"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="127"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="582"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ3715284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="706" mass="77035" checksum="85AA33F56A05E92C" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J347</accession>
    <name>A0AA38J347_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_842011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000082">
        <property type="protein sequence ID" value="KAJ3715919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J347"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3715919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="453" mass="50889" checksum="7C4A8BFF0F5FCBA8" modified="2024-01-24" version="1">MKVLDVTLRRYKSWWKQTLELFGGWKMSSEQQEPTGSSEGREGELRFESPSPSISLQQVEHISTNSSGMEHNAPKSTPRATVSQTISSTCLGWPLIDAESSPANLRESEGRSPHSLTTRPYHISSYSDNSEEYAGGNSNFLQASGRIQHRHRSFPASHATRTSTFVRNPCRSLFRDPPSSFRRSTEMRHHSDAHMRESSICTVDYSTYKAPSIDRMPFSNPNQYTHNAPTANTLTNYPSNGLAQELSPLEDFRPLQPDFEYNTDTEYQKQLREMNFGTPFGSFAHHSTGYGHASYYATAYRETEVAVLEEFWRKVSGDIATSTTTAKPELFSSQSDEHGAWQQPTWTQANLAPYDQLESTTASSLEPHAMSMEVENGISPDMAPTQHSHDVAVYSFNQGSEYPCNGQCDHGVLPDPQQTYVAHFFSPVLDNELDPSLLPGSLYHHDPYFNSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J3L2</accession>
    <name>A0AA38J3L2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1099066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000072">
        <property type="protein sequence ID" value="KAJ3717632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J3L2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3717632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="65726" checksum="7AC865FCE3706863" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J4D6</accession>
    <name>A0AA38J4D6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1101065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000078">
        <property type="protein sequence ID" value="KAJ3716326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J4D6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="484"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3716326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="849" mass="93491" checksum="85F6838613B10E42" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J516</accession>
    <name>A0AA38J516_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1093937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J516"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3722090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="503" mass="54155" checksum="376EE53B4DBB0D15" modified="2024-01-24" version="1">MSSSSSVHTIPIVTVQATFPTVANEVYSGVIPSETIWISCYDNSPPDARQLTSLGSIHAKVRVVLDDEDRERVVYQVREGDVHLSESARRDFGYVYTVSSPSLRIPLARLLFPVQEYADPERSNPQKPHRITAFSLSPDKSQFATGYLDGSVLLYPTVPIHNSQNKYPTSAMHSPSRSTYTSRRQALVSAASMSSGVSPALARAHRSSVTSLRFFPSSRVLLSSGADLTLQIFPADPISASAASSSGQSNKPVSSVRTFTAHTRSVTSSAIIDRGREIISSSMDGTIRVWDVSTGTEETLIHSAAGVGIGINRIFLDPNLVPTKDAEHPYKRRLYAALQDGSFEVLNLDDQQKPPKLVHKFRSERSVHGALNAIAVSQPTGAAGTVLIAVGSAKGVVSVYNASTYASAHFRRSDASIEDLGFVFLENTTDKLGLVIATADGLPWVASLRELPLSGVCDAQVSVYAELVGGDVDAVRHLSVHTADSGVEVWTASDDGIVRRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J547</accession>
    <name>A0AA38J547_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DFJ43DRAFT_1159421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J547"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="258"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ3718631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="340" mass="37043" checksum="626CBC7AF73E00EA" modified="2024-01-24" version="1">MAGDKDTLLAMGFDPARVEWALKATGNRGLQPAMDHILENESKSVPKMENVSASTASAATDAMDVDEDEEDAEALHSLGGVAANAVEAKSIKCTECGKIFKNTDLANFHAEKSGHDQFEESTEEIKPLTEEEKKERLDELRAKMAEKRSRKAIEEAAEQKANEQLRRKAGKDIHKVREELQAKEAIKEAQQKKRDKLEDAKARAAVKAQIEADKKARAEKAAREKALREGLPIENVDVSNPATAVPQSGSSISGVAGKDFKETRLQIRMSTGGQPYTTSLPSDSPLSAVAEFLAAQTLTVNVDTVTFAQHFPRKSFSRTDFSKSLRELGLTPSAVLIATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J5W7</accession>
    <name>A0AA38J5W7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1004251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000057">
        <property type="protein sequence ID" value="KAJ3722028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J5W7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3722028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="101" mass="11232" checksum="D3F84C424D583D0C" modified="2024-01-24" version="1">MFSSLTSTLRSTIIPSPIWLPRMFSMTSVAEAGYKMKSHSGAKKRWRSLGSGSSFKRGKANHQHLNVTKPPARKNRLSTTAYSTPAQTHKLKKLLLPYGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J6Q3</accession>
    <name>A0AA38J6Q3_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial ATP synthase g subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1127947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000105">
        <property type="protein sequence ID" value="KAJ3712765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J6Q3"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3712765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="181" mass="19870" checksum="E8C4E4796E771116" modified="2024-01-24" version="1">MLRPSSFRPALRSRAVRSTRFASTGSNPQLEAAQKKAQDVFSSTQQTATKAFENAKKIAGPLGETAGKYLARATKSAGPLGERAGKLMGTYKEPVLYNFTVFREILKQVYRAEGLSPPSSIDVVRSAYRTMWTNATSKAFWQKTISSGEVARLGVYALEAYGIFKIGEMVGRRSIVGYKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J777</accession>
    <name>A0AA38J777_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1086154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000041">
        <property type="protein sequence ID" value="KAJ3727317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J777"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3727317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111302" checksum="C82146CFE966FD81" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7K0</accession>
    <name>A0AA38J7K0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_587042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000047">
        <property type="protein sequence ID" value="KAJ3725057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7K0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3725057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28628" checksum="93D454E4CEF4EF4C" modified="2024-01-24" version="1">MALPETFDAFVPTNFADFFARVDIPTHIGLTELRELEGDIVNSFVISYKYAEKLCSQTILDHSLRCYYFSLAMLPNFPSNTPSVPQISRGELIKRVYLTCLLHDVGISSHEIATTHPAHDMTFEFHGGIMVYEHLRAEYIPSLQLDDSQIADITQSIMLHDVPFQTGMSSAAGMLVHVSAFIDIFGYDTAPPNTIERALHRDTKREIEKAFPRDGMTLFGVQVEEMMKAKPNCLLGHLPNFLEQFEKATTSTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J7N6</accession>
    <name>A0AA38J7N6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1000021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000034">
        <property type="protein sequence ID" value="KAJ3730957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J7N6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3730957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="282" mass="31870" checksum="786830DB2E270BF9" modified="2024-01-24" version="1" fragment="single">IQLRDGAQIPILGFGTYELESKDAYNAVTWALESGYRHIDSAEWYENERGCGKAILDFCRSHDVPRSSVFYTTKLKYNDGYEGVTRSIQKSLNECGLGYIDLYLIHGPIGGKTARLESWRAICEAHKSGKLKNIGISTFGIKHLQEILDFCSERSLPLPSVHQIDLHPFQVRSAIVEFSKRHGIILEASTNFSLAWAPLVRGLRFKHPSIVNLSQKHNKDPAQILLRYSLQKGYVAIPKSSSHTRIASNTQIFDFELSDKEIQDLDNLDEALVTDWDPTDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8A0</accession>
    <name>A0AA38J8A0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial outer membrane translocase complex, subunit Tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DFJ43DRAFT_1081052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000033">
        <property type="protein sequence ID" value="KAJ3731006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8A0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ3731006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="133" mass="14163" checksum="AE00C6A15BE255A7" modified="2024-01-24" version="1">MVKVEIVDEKESNSPYASDSSAASSSESLSSVDSEIANDETIFDRLAALVDIVPPTTRHKITSRIASTGSFFKTTGKVVGNIVWIVTTSALLVGLPLAVSLEDEAKLVAQEKEEQQAGQQVCSIVHILTPCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8H7</accession>
    <name>A0AA38J8H7_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1132519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000031">
        <property type="protein sequence ID" value="KAJ3731422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8H7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="200" mass="22533" checksum="8FE4B922AF2D9EC5" modified="2024-01-24" version="1">MCVKALIRDRYRCVITGIYDLSMRETQLTVHLKCAHIVPDSTYFDVEQTKKKGYSASVLAVLKRFGYDVELIHSDKVHSLFNIMTLSYDVHDAFDRLELWLEATNQANRYRVLTASKFLVPGGLPQFIEFTSSYPKLPLPSPDLLALHAICAQVAHLSGAGQYVEQLDRDVEELCVLAADGQSFHTLEHALMRATPSISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8J1</accession>
    <name>A0AA38J8J1_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_782910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000071">
        <property type="protein sequence ID" value="KAJ3718024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8J1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434:SF1">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434">
        <property type="entry name" value="CUPIN_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3718024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="92" mass="10400" checksum="1021210B9EFF247F" modified="2024-01-24" version="1">MLSQSEAEANVQAWGFQNVFTWTDRPNAHYPPHSHATRTTHLILQGEFIITYPKDTNPVKETFGSGSRIDVNADRIHEVWIGEQGCTYVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J8R4</accession>
    <name>A0AA38J8R4_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DFJ43DRAFT_1100704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000077">
        <property type="protein sequence ID" value="KAJ3716729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J8R4"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3716729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42339" checksum="4BBAF699F5D82A03" modified="2024-01-24" version="1">MSKGACAAALLDRDTLSEIFRACMELLDSPENCDSNSTYTTLDTSRAPWVLGQVCHSWRHIVLSSPLLWTSVNILLDRDGSEHNAARRALFLLDLYLSRSASCPLSVSIHSSTGFQRSPFFLRSLISASSRWHTLLINIPISSYETLSVLTGFLDSLKVLHIGVPYQNKSQAIRDFTNLRDGIRVFRFCNNLERLTLNDIPFPRDVLHLPWARIHCLSVHSTLSLVTNSITIRTLHGLPNLTSCSLECRFAINCGKLHRLTLPMLRSMTLFSAEHYHDTEAVEDSGLGAAQMLSWLTLPALNQLQLRQKFKIELEHSIVVEVIQLLRRSGCEIRGLQLHLCPSISEAGVMSILKEVSPSPEKLCPLPGYRAYYNLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J903</accession>
    <name>A0AA38J903_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1005722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J903"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="176" mass="19271" checksum="F02D086D7C9DA2A1" modified="2024-01-24" version="1">MGGELPQEEEEIDVNELGENDDLGPAAGPQTMSSIHLASKPVEGYPRYAASLGEHIKQPQLHNAIRCYLWGVQHGDSVQPTNVQACPPFASPISVFHSAIARFYAPSDVCGAGGMHLEHIWSHPFPREEHTHHDTVFVVTGDEPSMLGLTVARVVLFFSFKFHDVVHECALVPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J907</accession>
    <name>A0AA38J907_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator of RNA polII, SAGA, subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1077416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J907"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3731782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="323" mass="35992" checksum="D75A21B144C72C08" modified="2024-01-24" version="1">MSLSSTSHIKSQLTNNLGAKASTYFSCLQKFVTGRISRTEFDDTLKPILDAPYLIQLHNALIISLFDARSHKRPITPPPDQPKPPPRKRRRALPYQGPDTTDDELGSRSSRLKRWAITLGKAERERIRALPSAPPLNEPRKEVTEEIQRERPLYLPKEREEPPGSRPSISLATMSRAPTIQHIIERINLVCAQHNLHAPQRNVATLMHLACEVKLKQLITHALTLTTQSLAISSVSTGKASQPSTHQQNILTTAALEALFTIAPADLPNKSAAAMRLALGDRDGDDDDDIPILKKREVNDPRWQITALLAQRSAVRETLLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J943</accession>
    <name>A0AA38J943_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1165439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000101">
        <property type="protein sequence ID" value="KAJ3713241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J943"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="360"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="532"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="575"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="618"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="661"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="704"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="790"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="833"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3713241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110671" checksum="BB918550A05B9539" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38J9B6</accession>
    <name>A0AA38J9B6_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DFJ43DRAFT_1075193</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">ET3784</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="JANVFO010000026">
        <property type="protein sequence ID" value="KAJ3732022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38J9B6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ3732022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="255" mass="29068" checksum="2629414C67A789A5" modified="2024-01-24" version="1">MVASEFPGRSNKLILFDVDNTLTRARQTITPAMTKVLQELKKKAVIGFVGGSDFVKISEQLSVNRSNVVEDFDYAFAENGLTAYKLGKPLPSQSFIKFLGEERYKPLVNFILHYLADLDIPIKRGTFVEFRNGMINVSPLGRNATIAERDEFEVYDKKQGIRAAFVKVLQEKFADYGLTFSIGGKISFDIFPRGWDKTYALRHVEHEGYEEIHFFGDKTYKGGNDYEIFADPRTIGHSVENPEDTIKQLKEIFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JA05</accession>
    <name>A0AA38JA05_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FUN34 transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DFJ43DRAFT_1215061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000090">
        <property type="protein sequence ID" value="KAJ3714608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JA05"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ3714608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="240" mass="25645" checksum="210856E55901BB7F" modified="2024-01-24" version="1">MASAANDAEKGRVENLTGNGGTRGSTDIEEYGPRSGDPVSYQRYPSHIANPGPMGLFSFASTTFILSMYNVGTRGISHPNVVVGMAIFAGLGGLTQFIAGMWEFPRGNVFGATAFASYGSFWMSYATIFIPGSGIMAAFNNPQELNNAVGIYLISWFMITVFFLLAVLRRNVAFTVLLSALSVALLLLAVAEWNGMEQLQKGGGVFGIITGLIAFYIGVSELLRAEPRAVARLPLGLLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAA0</accession>
    <name>A0AA38JAA0_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1080777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000032">
        <property type="protein sequence ID" value="KAJ3731274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAA0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57469" checksum="4CFC7C35C2EF045A" modified="2024-01-24" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAD5</accession>
    <name>A0AA38JAD5_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_1138420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000021">
        <property type="protein sequence ID" value="KAJ3732832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAD5"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3732832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="384" mass="43575" checksum="1854766C8897CCD4" modified="2024-01-24" version="1">MQQPALSSFSVSAAFPHPIKQEDITIPRSLLYIIVSSLFISFLLLIVSLLDFGYCSLWLTPPLCLFTLLYFSGVLVLSRMERSAEDPTYFPTVVFIGYIMTIFWLVSFILTVVVFAVYPHIVDGLRQLGLHTVSVGLQRFQCLLCMVNLGLVGGFTARSHVIAMEEGDPENWRILVEKIQNPAAHRPIRVHHHVNLNDPSMIREPREAPTPTIQPDWITAAILEDNMTVAPRTPKPPSSPCPQIEISPPGPVDDLYDEAYMNDYHREEVPARPISPRTPHSPRVSPSPHAPQSPYAPRSPRGEPTEAESEHYQTEKEHFERVYSPRQPVFSPDHPVHSSQSPYHPQAMPYDTDSVYDDSEPPETPDRWSDEDEVEEEYHAPHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAL8</accession>
    <name>A0AA38JAL8_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_661233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000054">
        <property type="protein sequence ID" value="KAJ3722832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAL8"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3722832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="198" mass="21620" checksum="086C7F1F67F9FA88" modified="2024-01-24" version="1">MAHIQGNLPLAMKEENERFFRHFVGTPQTSYGADVGKNIKLTGANVFLPVKLEELTEAEAQKAKRNAETETICEIEVTKDMCNIYGTLHGGCAAYIIDLCSSTAIVCYGLYTATDGTGVSSSMNIHWHRPITVGKKLKIISNTVFVDGLIRNAKSELRDLQTNKLYVSAVHSTLAGGSRTAALRKSSKEKAEKINAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAV2</accession>
    <name>A0AA38JAV2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cwf21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DFJ43DRAFT_1101851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000083">
        <property type="protein sequence ID" value="KAJ3715612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAV2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ3715612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="384" mass="44518" checksum="E451C535EADC4728" modified="2024-01-24" version="1">MYNGIGLTTPRGSGTNGYVVRNLSTLRSYEPAQDRAAAWDVAPPKYREPDQGILEHERKRQVEVKCLELQLELEDKGIDEDEIEKQVDELRTKLNANLNAYAAPSTKRFKPSDTHAIAEAKKSELDKMARALGTRRDYTEGQAFDREKQEQDKIKRQIEREERERRKEEERAKMVEQKAKWDAERREKDRLRRREEDRLRREREEGGADLRRKQDIRSMPPPPPPSGRERSRERYRGRDRSPLRRRRDSRSRSPRRRSPSPPPRPSRRRSPSASRSPSPSRSGSPPRTRRRSVSPPRRRSRTPLSPHGNRRDQRSVTAPSRRRRSRSDPGSPPRDGAESKGRGRSPSPRESRRSRSRSRSRSRSVSSDSAMSVSTSSSSRSRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JAW1</accession>
    <name>A0AA38JAW1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1042875</name>
        <name evidence="1" type="ORF">DFJ43DRAFT_1044456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000126">
        <property type="protein sequence ID" value="KAJ3711080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JANVFO010000068">
        <property type="protein sequence ID" value="KAJ3718649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JAW1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ3711080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3718649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25166" checksum="F11197D2D0BCAEC5" modified="2024-01-24" version="1">MSQKLTEEVVTAYICAIDYVVSKSVGKWLPVENPNIMDEDELEQPSEPSTDSPEHGLVLECENNNQAIHAVIFYRYAKDILHEFEKRTASLDMKTAAIELSLTFICDNQIIERDPSLWAEFLCISSQDNQGLKDLERTVVFKILLASPYIHLRTSHMCIQVAGLFFTTSSMLEKVKVVQHWFFALTRIEISGGDGNGGLPGLKKFTETHLCTAICKKLGFNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JBK7</accession>
    <name>A0AA38JBK7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_995026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000017">
        <property type="protein sequence ID" value="KAJ3733582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JBK7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3733582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="217" mass="22805" checksum="E925CA623CB17BA2" modified="2024-01-24" version="1">MSALASLSSCEISDALIKLGVPSGGYIPDINHFSGKPICGPAYTVKFVHSTETDAPKLSEHFVDTAPSGSVIVVEAPLHAKNAVWGGLMTAGAQARNALGVVISGRCRDLAEHRDLAFPVFARGHSTVGQSPFTRPSAINVSLDLIPEGNSTFPSTQVNPGDWVIADEDGVVCVPKELEVMVADLAMKSHAIDEKCMADIRAGKGVKASFAEHRGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCH2</accession>
    <name>A0AA38JCH2_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DFJ43DRAFT_1073724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000024">
        <property type="protein sequence ID" value="KAJ3732399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCH2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="184"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ3732399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="354" mass="39553" checksum="C4697F67C247F9FA" modified="2024-01-24" version="1">MAVPININTTLGFLSHAVVLCCILYGAGCMQAWFYYRKYSRRDSWAIQVLVAAVVICDTCQIGFLYAAVYNYTVTNQGNPLALAKIDKNLIIELLFSGMIAFLVQHFYCHRIYALSKSRLLAGLVSLTSLGSLVTLYYFIGVVLSQYTELAQLALLDVRWRFPSHFVKLTQLQNISVVTNVLGIVSDLAITFLMIYLLQRSKTGFKNTTDVLNRLIVFTFNTGWSIQSFLFIKPEKRLGIPTSLCSIVTLILLEGVPGTFIYIFVYVSMGRFYTNCLLVTLNSRDYIRQGLSSNGASTSENYAMSIPTNALESRLEFAGTGSTAEGITIRIDRDTHTSSPKHRRGDSIDLPQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JCQ2</accession>
    <name>A0AA38JCQ2_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1109215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000145">
        <property type="protein sequence ID" value="KAJ3710123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JCQ2"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3710123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="571" mass="62760" checksum="4126D6A77BDA23E7" modified="2024-01-24" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JE38</accession>
    <name>A0AA38JE38_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DFJ43DRAFT_1130312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000010">
        <property type="protein sequence ID" value="KAJ3735352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JE38"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ3735352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="202" mass="23532" checksum="C7BD25860F8CE1BB" modified="2024-01-24" version="1">MTPRDIEHINLRSQKRLAASVAGVGKRKVWLDPAEQAEIGNANSRTHIKKLIKDHRVIIKPTVIHSRSRTRDLLAAKRKGRHTGPGKRKGTAEARMPTKVLWMRRQRVLRRLLRKYREAGKIDKHLYHSLYQKSKGNVFKNKRVLMEYIHKAKAEKTRTKVLTDQMEARRVKNKAARERRAARVLEKRQAILAVEHDAPVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFF7</accession>
    <name>A0AA38JFF7_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_884330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000092">
        <property type="protein sequence ID" value="KAJ3714342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFF7"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3714342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="432" mass="47799" checksum="CC0F045F058050CD" modified="2024-01-24" version="1">MSQHDHLLKQLCGSSSETLARARELLYIATVRTAPGTGFQLKDPLGRPAACALIASEQLKNTVVDPASAQGNSCLNPTAFQKCLAQVRAALAHNASYQPSDPTKRRQTRSEFISQISYDSLVAKYALLQTYGDRFVSWCQRAEFAFFDLGKGNNIARDSPKIKLGIFFWVYGILEPDRLDLASFVKNNGAHTDNTGGITKIMDVHGSKIRALILAESKRPKETVATRSSTRISPGKRPMREAPSKDSPKKRKLSAEDDTVETTAGKQFSVPNHASGPPKVLFPPSTSLRNSPSKQVLRELPTKSTTKKTRFTVVGQEDSDVEMSLPDTPSKRRLLGTSSDQVPMISSSRPRAPSPSPTRRSIRLNSATESPSQTVVNIKDLYIDNPPERANMFATTVRRRFRPVFLDRKQWSAPDPLLVKLQNRINKVTIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFR0</accession>
    <name>A0AA38JFR0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DFJ43DRAFT_1005237</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">ET3784</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000064">
        <property type="protein sequence ID" value="KAJ3719643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFR0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ3719643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="445" mass="49514" checksum="90A95B17B0EF790D" modified="2024-01-24" version="1">MGQHMIIVNSGEIMEQLDKRGSIHSDRPRLEMAGELVGYSKTLVLVPYGQRLRNYRRYVSKMIGSLSALSQFHPMIEAETHMFLKRTAANPHSDVISHNLRKTSGSIILKLSYGIEVQEENDPFVSLIERANDNFSLATKPGAFLVDVFPSLRHIPPGFPGAKFHELAAKWAKDFNDMIEIPFNFTRELMSKGTAPVSFVSASLEHEDKLTENEIFEIKHTAASIYAAGADTTVSDQYSVFLAMVVTPFKSFCSEVLKKAQAEIDAVVGNERLPAFSDREHLPYLNAVLTEALRWNSVAPTGVPHRSMEDDIIGGYLIPKGSIIIANLWNMLNDPAVYPDPFKFDPERHISSPGKPAQKDPRHACFGFGRRICVGMQLAEASLWIFIAMTLAVFDISPVLDGKGNPIIPEHENTTGTISHPKPFQCVIRPRSEKALSLISTEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFT1</accession>
    <name>A0AA38JFT1_9AGAR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DFJ43DRAFT_1205550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ET3784</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000063">
        <property type="protein sequence ID" value="KAJ3720210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFT1"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ3720210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="285" mass="31560" checksum="89900C70459CAEDF" modified="2024-01-24" version="1">MDLGSNFAAKLEQYLLMGKSMRGAAAAKLIQSATSAPGVFVFGELFDLPGIRNLEKDEQYSQSYALLQLFAYKTYQDYLENKDQLPILNEAQTIKLKHLSIVSMATERRILPYPLLMSRLAMSTIRELEDLIIDAIYLDILRGKLDQKESQLEVEYTMGRDLEPGKVEAMLSALKNWASTTSAVLATLDSQISSLSSQNAFNKKQKDDYEAHVQQLIKEVGEKKESAPAYSSGKKPLASHGQATTGTGDRMDVDEPEGSAAGGPKGKNRKAPQAETKSSRKRNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JFZ6</accession>
    <name>A0AA38JFZ6_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1077653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000028">
        <property type="protein sequence ID" value="KAJ3731824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JFZ6"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ3731824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="279" mass="31942" checksum="C6936C3D41A48CEE" modified="2024-01-24" version="1">MAPIMFHNRSYGASACPIPTAKHEQEAVRFKLAKLEDEEGDEEDYSADDEGGMDFESSFDTSFDAQQDHHQSLGDMYSGFFGAAKNRDMSNRPSSTDIRTHVLNYQTDIEEDEWDEAEILEEHECSPNCFTCRISTSIRRIQHPELYYSSDEEDDFEDCTTSMPATHCVPDCISCARERLRAEGYKFPRYQYDQSDHTEDDDQSEMQELSKPSKQGIKQEEAEVKDSERRGSFNFSLIFTPPHSGLQKQAESTARSVELIEPFPRVFFPPPKTSDTDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JGY0</accession>
    <name>A0AA38JGY0_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA replication regulator Sld3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DFJ43DRAFT_986738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-Duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Donoghue J."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Grigoriev I.V."/>
                <person name="Hibbett D."/>
            </authorList>
            <dbReference type="PubMed" id="36848567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ET3784</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JANVFO010000027">
        <property type="protein sequence ID" value="KAJ3731892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AA38JGY0"/>
    <dbReference type="Proteomes" id="UP001176059">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ3731892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001176059"/>
        </source>
    </evidence>
    <sequence length="410" mass="46359" checksum="6E2C8B2D88224F2C" modified="2024-01-24" version="1" fragment="single">IKWSTSQEKSVNREYPFTDLNNETPEQFVVRNYLQFLWLPESLMPLDLLVASLRRVQVASTSTDSLSSPHPLHALLDPILLTARTAANKYQTELPRILDNGGGAGEIEETMMWFVLSSEKPHESQHERERTRTNSGSSVNSAQSVESPVWLDEKWRASWIRRMERREVQIQILIHLLILSLPGPPPPRPDSPEMSSVKRRKRPRKKTARITTPEERLEAFMDKLSMWQLMGDLDANGKTRATDKANNELDWIQLFCSNVVVPLFGSTLPTLCELLRSKVFPNSPFSDDEDEHQDSPLTNAESPSSPPPQPPLKRTRLATSDVVSEVPTRHTSPALSTSSTSSAREQKRGPSHQDSRQRSALQRNRSRSLSISLAEEAEEKHKAKKTVMGSNKGRVLSREVSMSFKTKSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-01-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AA38JH14</accession>
    <name>A0AA38JH14_9AGAR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DFJ43DRAFT_1040241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Lentinula guzmanii</name>
        <dbReference type="NCBI Taxonomy" id="2804957"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Agaricomycetidae</taxon>
            <taxon>Agaricales</taxon>
            <taxon>Marasmiineae</taxon>
            <taxon>Omphalotaceae</taxon>
            <taxon>Lentinula</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Min B."/>
                <person name="Sierra-Patev S."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person name="Ferreira P."/>
                <person name="Molpeceres G."/>
                <person name="Ruiz-duenas F.J."/>
                <person name="Serrano A."/>
                <person name="Henrissat B."/>
                <person name="Drula E."/>
                <person name="Hughes K.W."/>
                <person name="Mata J.L."/>
                <person name="Ishikawa N.K."/>
                <person name="Vargas-Isla R."/>
                <person name="Ushijima S."/>
                <person name="Smith C.A."/>
                <person name="Ahrendt S."/>
                <person name="Andreopoulos W."/>
                <person name="He G."/>
                <person name="LaButti K."/>
                <person name="Lipzen A."/>
                <person name="Ng V."/>
                <person name="Riley R."/>
                <person name="Sandor L."/>
                <person name="Barry K."/>
                <person name="Martinez A.T."/>
                <person name="Xiao Y."/>
                <person name="Gibbons J.G."/>
                <person name="Terashima K."/>
                <person name="Hibbett D.S."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ET3784</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2023" name="Proc. Natl. Acad. Sci. U.S.A." volume="120" first="0" last="0">
            <title>A global phylogenomic analysis of the shiitake genus Lentinula.</title>
            <authorList>
                <person name="Sierra-Patev S."/>
                <person name="Min B."/>
                <person name="Naranjo-Ortiz M."/>
                <person name="Looney B."/>
                <person name="Konkel Z."/>
                <person name="Slot J.C."/>
                <person name="Sakamoto Y."/>
                <person name="Steenwyk J.L."/>
                <person name="Rokas A."/>
                <person name="Carro J."/>
                <person name="Camarero S."/>
                <person n